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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Tyrosinase inhibitory activity of Sargassum fusiforme and characterisation of bioactive compounds | IntroductionSargassum fusiforme (Harvey) Setchell, also known as Tot (in Korean) and Hijiki (in Japanese), is widely consumed in Korea, Japan, and China due to its health promoting properties. However, the bioactive component behind the biological activity is still unknown. ObjectivesWe aimed to optimise the extraction conditions for achieving maximum tyrosinase inhibition activity by using two sophisticated statistical tools, that is, response surface methodology (RSM) and artificial neural network (ANN). Moreover, high-resolution mass spectrometry (HRMS) was used to tentatively identify the components, which are then further studied for molecular docking study using 2Y9X protein. MethodologyRSM central composite design was used to conduct extraction using microwave equipment, which was then compared to ANN. Electrospray ionisation tandem mass spectrometry (ESI-MS/MS) was used to tentatively identify bioactive components, which were then docked to the 2Y9X protein using AutoDock Vina and MolDock software. ResultsMaximum tyrosinase inhibition activity of 79.530% was achieved under optimised conditions of time: 3.27 min, temperature: 128.885 degrees C, ethanol concentration: 42.13%, and microwave intensity: 577.84 W. Furthermore, 48 bioactive compounds were tentatively identified in optimised Sargassum fusiforme (OSF) extract, and among them, seven phenolics, five flavonoids, five lignans, six terpenes, and five sulfolipids and phospholipids were putatively reported for the first time in Sargassum fusiforme. Among 48 bioactive components, trifuhalol-A, diphlorethohydroxycarmalol, glycyrrhizin, and arctigenin exhibited higher binding energies for 2Y9X. ConclusionTaken together, these findings suggest that OSF extract can be used as an effective skin-whitening source on a commercial level and could be used in topical formulations by replacing conventional drugs. | Javed, Ahsan; Alam, Md Badrul; Naznin, Marufa; Shafique, Imran; Kim, Sunghwan; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Inner Beauty Antiaging Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Kyungpook Natl Univ, Mass Spect Converging Res Ctr, Green Nano Mat Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea | Kim, Sunghwan/HKN-9812-2023; Alam, Md Badrul/AFL-7668-2022; Javed, Ahsan/ABK-2648-2022; Lee, Seung Eun/ABG-1607-2021 | 57204433098; 56706777100; 57195955389; 57807644800; 57203772967; 57221453703 | sunghwank@knu.ac.kr; sang@knu.ac.kr; | PHYTOCHEMICAL ANALYSIS | PHYTOCHEM ANALYSIS | 0958-0344 | 1099-1565 | 36 | 2 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL;PLANT SCIENCES | 2024 | 2.6 | 33.2 | 4.38 | 2025-05-07 | 5 | 5 | artificial neural network; optimisation; response surface methodology; Sargassum fusiforme; tyrosinase | MICROWAVE-ASSISTED EXTRACTION; SURFACE METHODOLOGY RSM; EFFICIENT OPTIMIZATION; MUSHROOM TYROSINASE; PHENOLIC-COMPOUNDS; SARGAQUINOIC ACID; MELANOGENESIS; ACCURACY; DOCKING; LEAVES | artificial neural network; optimisation; response surface methodology; Sargassum fusiforme; tyrosinase | Edible Seaweeds; Enzyme Inhibitors; Molecular Docking Simulation; Monophenol Monooxygenase; Neural Networks, Computer; Sargassum; Sargassum fusiforme; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Binding energy; Bioactivity; Electrodeposition; Electrospray ionization; Extraction; Mass spectrometry; Phospholipids; Proteins; Statistical mechanics; Surface properties; 3' o methylequol; 3,5 dihydroxy 6,7 megastigmadien 9 one; 4 hydroxybenzaldehyde; 5 (3',4' dihydroxyphenyl)valeric acid; arctigenin; caffeic acid; carnosic acid; carnosol; conidendrin; coumaric acid; coumaroylquinic acid; dalbergin; deoxyschisandrin; depigmenting agent; dihydroactinidiolide; dihydrobiochanin a; dimethylmatairesinol; diphlorethohydroxycarmalol; epicatechin; epigallocatechin; exifone; ferulic acid; flavonoid; gibberellic acid; glycitein 7 o glucuronide; glycyrrhizic acid; hispidulin; humulene epoxide II; hydroxytyrosol 4 o glucoside; isoamijiol; isohydroxymatairesinol; lignan derivative; loliolide; lubiminol; lupenone; monophenol monooxygenase; oxygenase inhibitor; phospholipid; plant extract; quinic acid; salicylic acid; sargahydroquinoic acid; sargaquinoic acid; Sargassum fusiforme extract; secoisolariciresinol; sinapic acid; sulfolipid; syringic acid; tannin derivative; terpene derivative; trifuhalol a; unclassified drug; urolithin a; enzyme inhibitor; monophenol monooxygenase; Bioactive components; Bioactive compounds; Inhibition activity; Japan and China; Optimisations; Response-surface methodology; Sargassum fusiforme; Tyrosinase; Tyrosinase inhibition; Tyrosinase inhibitory activities; Article; artificial neural network; binding affinity; central composite design; comparative study; drug screening; electrospray mass spectrometry; high performance liquid chromatography; IC50; mass spectrometry; melanogenesis; metabolic fingerprinting; molecular docking; molecular interaction; nonhuman; response surface method; Sargassum fusiforme; validation study; chemistry; edible seaweed; procedures; Sargassum; Sargassum fusiforme; tandem mass spectrometry; Neural networks | English | 2025 | 2025-03 | 10.1002/pca.3233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Analysis of gravity movement and future projections of greenhouse gas emissions in South Korea | This study investigates the shifting patterns of greenhouse gas (GHG) emissions across 17 administrative regions in South Korea from 2000 to 2020, analyzing their movement and the underlying driving factors. Using the center of gravity method, the GHG emission center shifted northwest toward capital regions mainly due to zone 2 and 3 related to industrial activities and urbanization during the four distinct phases. National trends in GHG emission changes were assessed using the LMDI method, revealing that economic development and population effects were the primary drivers of emission increases, while energy intensity and fossil fuel effects mitigated emissions. Regionally, energy intensity and population effects are the two main driving factors positively and negatively influencing GHG emissions. Cluster analysis identified four distinct groups of regions; urban efficiency (Cluster 1), economic development with low fossil fuel use (Cluster 2), industrial reliance (Cluster 3) and administrative low-emission (Cluster 4). Projection models show varying future emission trajectories by 2030, 567.2, 637.9, and 708.7 million tCO₂eq. in the advanced, moderate, and business-as-usual scenarios, respectively. Still further aggressive emission reduction measures are required to meet 436.6 million tCO₂eq. of 2030 Nationally Determined Contribution target. Investigation of national and regional energy consumption structures would help establish policies for sustainable development among local governments. © The Author(s), under exclusive licence to Springer Nature B.V. 2025. | Nam, Hoseok; Nam, Hyungseok; Lee, Doyeon | Busan Development Institute, Busan, 47210, South Korea; School of Mechanical Engineering & IEDT, Kyungpook National University, Daegu, 41566, South Korea, Department of Energy Convergence and Climate Change, Kyungpook National University, Daegu, 41566, South Korea; Department of Civil and Environmental Engineering, Hanbat National University, Daejeon, 34158, South Korea | 57198350465; 57190418228; 55881252900 | namhs219@knu.ac.kr; | Environment, Development and Sustainability | ENVIRON DEV SUSTAIN | 1387-585X | 1573-2975 | SCIE | ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 4.2 | 33.3 | 0 | 2025-05-07 | 0 | Decomposition analysis; Gravity movement; Greenhouse gas emission; Scenario analysis; South Korea | English | Article in press | 2025 | 10.1007/s10668-025-06003-y | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer | Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) is a promising strategy that can enhance the therapeutic efficacy of ICIs. However, little is known about RT-induced changes in the expression of immune checkpoints, such as PD-L1, and their clinical implications in colorectal cancer (CRC). This study aimed to investigate the association between responsiveness to RT and changes in PD-L1 expression in human CRC tissue and cell lines. Methods: Tissue specimens from preoperative biopsy via sigmoidoscopy and surgical resection were obtained from 24 patients with locally advanced rectal cancer (LARC) who underwent neoadjuvant chemoradiation therapy (CRT) between August 2016 and December 2017. Immunohistochemistry for PD-L1 in formalin-fixed paraffin-embedded tissue was performed from the endoscopic biopsy and surgical specimens. RNA sequencing was performed using 11 pairs of human LARC tissues before and after irradiation. After exposing human CRC cells to radiation, we investigated changes in the expression levels of PD-L1 and its regulatory signaling pathways. Results: Patients were classified by tumor regression grade into responders (grade 2; 9 patients, 37.5 %) and non- responders (grades 3, 4, or 5; 15 patients, 62.5 %). In the non-responder group, 13 patients had low PD-L1 expression, but neoadjuvant CRT increased PD-L1 expression in 7 patients (53.9 %) (McNemar's test, p=0.034). CRT up-regulated PD-L1 in non-responder LARC tissues. Similarly, radiation increased PD-L1 in radioresistant DLD-1 cells more than in radiosensitive HCT116 cells, also affecting PD-L1-regulating genes and immune checkpoints in CRC cells. Conventional fractionated radiation treatment further increased PD-L1 in DLD1 cells compared to HCT116 cells. Conclusions: This study demonstrated that radiation induces an increase in PD-L1 expression, which is more pronounced in radioresistant CRC, proving the theoretical framework for a combined treatment strategy with a PD-L1 blockade for locally advanced rectal cancer. | Bae, Sung Uk; Lee, Hye Won; Park, Jee Young; Seo, Incheol; Cho, Jae-Min; Kim, Jin Young; Lee, Ju Yup; Lee, Yoo Jin; Baek, Seong Kyu; Kim, Nam Kyu; Byun, Sang Jun; Kim, Shin | Keimyung Univ, Sch Med, Dept Surg, Daegu, South Korea; Dongsan Hosp, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Yonsei Univ, Grad Sch, Dept Med, Seoul, South Korea; Keimyung Univ, Inst Med Sci, Daegu, South Korea; Keimyung Univ, Inst Canc Res, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Daegu 42601, South Korea; Keimyung Univ, Sch Med, Dept Radiat Oncol, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Keimyung Univ, Sch Med, Dept Immunol, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Div Hematol & Oncol, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Div Colorectal Surg,Dept Surg,Colorectal Canc Clin, Seoul, South Korea | Bae, Sung/W-1915-2019 | 59485396500; 59853649500; 59485266300; 56022683900; 59485396600; 59484998800; 59485660400; 59484738100; 59798487700; 35269088900; 55446661100; 57210866288 | kryph@dsmc.or.kr; god98005@dsmc.or.kr; | CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | CLIN TRANSL RAD ONCO | 2405-6308 | 51 | SCIE | ONCOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 2.7 | 33.3 | 0 | 2025-05-07 | 0 | 0 | Locally advanced rectal cancer; PD-L1; Chemoradiotherapy; Immune checkpoint inhibitors | TOTAL MESORECTAL EXCISION; RECTAL-CANCER; MICROSATELLITE INSTABILITY; IONIZING-RADIATION; EXPRESSION; RADIOTHERAPY; IRRADIATION; INHIBITION; LIGAND; REPAIR | Chemoradiotherapy; Immune checkpoint inhibitors; Locally advanced rectal cancer; PD-L1 | B Raf kinase; carcinoembryonic antigen; cyclin D1; cyclin D2; cyclin D3; cyclin dependent kinase 4; interleukin 17; interleukin 27; interleukin 4; Janus kinase 2; membrane protein; programmed death 1 ligand 1; STAT1 protein; STAT2 protein; STAT3 protein; tumor necrosis factor receptor associated factor 6; uvomorulin; adult; aged; Article; bioinformatics; body mass; chemoradiotherapy; clonogenic assay; colorectal cancer; DLD-1 cell line; endoscopic biopsy; female; gene expression; HCT 116 cell line; histology; human; human cell; human tissue; immunohistochemistry; irradiation; lymph vessel metastasis; male; microsatellite instability; neoadjuvant chemoradiotherapy; overall survival; perineural invasion; protein expression; quality control; radiation exposure; real time polymerase chain reaction; rectum cancer; risk factor; RNA extraction; RNA isolation; RNA sequence; sigmoidoscopy; tumor associated leukocyte; tumor regression; upregulation; Western blotting; XTT assay | English | 2025 | 2025-03 | 10.1016/j.ctro.2024.100906 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Nuclear Medicine Imaging in Differentiated Thyroid Cancer: Summary of the Korean Thyroid Association Guidelines 2024 from Nuclear Medicine Perspective, Part-I | Thyroid cancer, one of the most common endocrine tumors, generally has a favorable prognosis but remains a significant medical and societal concern due to its high incidence. Early diagnosis and treatment of differentiated thyroid cancer (DTC) significantly affect long-term outcomes, requiring the selection and application of appropriate initial treatments to improve prognosis and quality of life. Recent advances in technology and health information systems have enhanced our understanding of the molecular genetics of thyroid cancer, facilitating the identification of aggressive subgroups and enabling the accumulation of research on risk factors through big data. The Korean Thyroid Association (KTA) has revised the "KTA Guidelines on the Management of Differentiated Thyroid Cancers 2024" to incorporate these advances, which were developed by a multidisciplinary team and underwent extensive review and approval processes by various academic societies. This article summarizes the 2024 KTA guidelines for nuclear medicine imaging in patients with DTC, written by the Nuclear Medicine members of the KTA Guideline Committee, and covers 18F-FDG PET/CT and radioiodine imaging with SPECT/CT in the management of DTC. | Oh, So Won; Park, Sohyun; Chong, Ari; Kim, Keunyoung; Bang, Ji-In; Seo, Youngduk; Hong, Chae Moon; Lee, Sang-Woo | Seoul Natl Univ, Boramae Med Ctr, Dept Nucl Med, Seoul, South Korea; Natl Canc Ctr, Dept Nucl Med, Goyang, South Korea; Chosun Univ Hosp, Dept Nucl Med, Gwangju, South Korea; Pusan Natl Univ Hosp, Dept Nucl Med, Busan, South Korea; CHA Bundang Med Ctr, Dept Nucl Med, Seongnam, South Korea; Chungnam Natl Univ, Sejong Hosp, Dept Nucl Med, Sejong, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu, South Korea | Lee, Sangwoo/MVV-2859-2025 | 36154944900; 56870601600; 26533830900; 36523010700; 56504705800; 57202988600; 37050876700; 57196249819 | swleenm@knu.ac.kr; | NUCLEAR MEDICINE AND MOLECULAR IMAGING | NUCL MED MOLEC IMAG | 1869-3474 | 1869-3482 | 59 | 1 | ESCI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 2.7 | 33.3 | 2.53 | 2025-05-07 | 1 | 1 | Thyroid cancer; Guideline; Differentiated thyroid cancer; Korean thyroid association | WHOLE-BODY SCAN; POSITRON-EMISSION-TOMOGRAPHY; PREABLATION 131-I SCANS; F-18 FDG PET/CT; ELEVATED THYROGLOBULIN; I-131 SPECT/CT; RADIOIODINE THERAPY; DIAGNOSTIC-VALUE; CARCINOMA; MANAGEMENT | Differentiated thyroid cancer; Guideline; Korean thyroid association; Thyroid cancer | fluorodeoxyglucose f 18; radioactive iodine; adult; clinical practice guideline; differentiated thyroid cancer; endocrine tumor; human; medical information system; multidisciplinary team; nuclear medicine; positron emission tomography-computed tomography; quality of life; radiotherapy; review; risk factor; single photon emission computed tomography-computed tomography; surgery; thyroid cancer; thyroid gland | English | 2025 | 2025-02 | 10.1007/s13139-024-00885-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Radioactive Iodine Therapy in Differentiated Thyroid Cancer: Summary of the Korean Thyroid Association Guidelines 2024 from Nuclear Medicine Perspective, Part-II | Thyroid cancer, one of the most common endocrine tumors, generally has a favorable prognosis but remains a significant medical and societal concern due to its high incidence. Early diagnosis and treatment of differentiated thyroid cancer (DTC) significantly affect long-term outcomes, requiring the selection and application of appropriate initial treatments to improve prognosis and quality of life. Recent advances in technology and health information systems have enhanced our understanding of the molecular genetics of thyroid cancer, facilitating the identification of aggressive subgroups and enabling the accumulation of research on risk factors through big data. The Korean Thyroid Association (KTA) has revised the "KTA Guidelines on the Management of Differentiated Thyroid Cancers 2024" to incorporate these advances, which were developed by a multidisciplinary team and underwent extensive review and approval processes by various academic societies. This article summarizes the 2024 KTA guidelines for radioactive iodine (RAI) therapy in patients with DTC, written by the Nuclear Medicine members of the KTA Guideline Committee, and covers RAI therapy as initial management of DTC and RAI therapy in advanced thyroid cancer. | Oh, So Won; Park, Sohyun; Chong, Ari; Kim, Keunyoung; Bang, Ji-In; Seo, Youngduk; Hong, Chae Moon; Lee, Sang-Woo | Seoul Natl Univ, Boramae Med Ctr, Dept Nucl Med, Seoul, South Korea; Natl Canc Ctr, Dept Nucl Med, Goyang, South Korea; Chosun Univ Hosp, Dept Nucl Med, Gwangju, South Korea; Pusan Natl Univ Hosp, Dept Nucl Med, Busan, South Korea; CHA Bundang Med Ctr, Dept Nucl Med, Seongnam, South Korea; Chungnam Natl Univ, Sejong Hosp, Dept Nucl Med, Sejong, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu, South Korea | Lee, Sangwoo/MVV-2859-2025 | 36154944900; 56870601600; 26533830900; 36523010700; 56504705800; 57202988600; 37050876700; 57196249819 | swleenm@knu.ac.kr; | NUCLEAR MEDICINE AND MOLECULAR IMAGING | NUCL MED MOLEC IMAG | 1869-3474 | 1869-3482 | 59 | 1 | ESCI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 2.7 | 33.3 | 0 | 2025-05-07 | 0 | 0 | Thyroid cancer; Guideline; Differentiated thyroid cancer; Korean thyroid association | WHOLE-BODY SCAN; 2ND PRIMARY MALIGNANCY; POSTOPERATIVE RADIOIODINE THERAPY; RECOMBINANT HUMAN THYROTROPIN; LOW-DOSE RADIOIODINE; QUALITY-OF-LIFE; REMNANT ABLATION; SERUM THYROGLOBULIN; I-131 THERAPY; TRIIODOTHYRONINE WITHDRAWAL | Differentiated thyroid cancer; Guideline; Korean thyroid association; Thyroid cancer | English | 2025 | 2025-02 | 10.1007/s13139-024-00886-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Conceptual Study of Rapidly Reconfigurable and Scalable Optical Convolutional Neural Networks Based on Free-Space Optics Using a Smart Pixel Light Modulator | The smart-pixel-based optical convolutional neural network was proposed to improve kernel refresh rates in scalable optical convolutional neural networks (CNNs) by replacing the spatial light modulator with a smart pixel light modulator while preserving benefits such as an unlimited input node size, cascadability, and direct kernel representation. The smart pixel light modulator enhances weight update speed, enabling rapid reconfigurability. Its fast updating capability and memory expand the application scope of scalable optical CNNs, supporting operations like convolution with multiple kernel sets and difference mode. Simplifications using electrical fan-out reduce hardware complexity and costs. An evolution of this system, the smart-pixel-based bidirectional optical CNN, employs a bidirectional architecture and single lens-array optics, achieving a computational throughput of 8.3 x 1014 MAC/s with a smart pixel light modulator resolution of 3840 x 2160. Further advancements led to the two-mirror-like smart-pixel-based bidirectional optical CNN, which emulates 2n layers using only two physical layers, significantly reducing hardware requirements despite increased time delay. This architecture was demonstrated for solving partial differential equations by leveraging local interactions as a sequence of convolutions. These advancements position smart-pixel-based optical CNNs and their derivatives as promising solutions for future CNN applications. | Ju, Young-Gu | Kyungpook Natl Univ, Dept Phys Educ, 80 Daehakro,Bukgu, Daegu 41566, South Korea | 59812801600 | ygju@knu.ac.kr; | COMPUTERS | COMPUTERS | 2073-431X | 14 | 3 | ESCI | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | 2024 | 4.2 | 33.4 | 0 | 2025-05-07 | 1 | 1 | optical neural network; convolution; smart pixel | convolution; optical neural network; smart pixel | Laser beams; Lenses; Multilayer neural networks; Optical phase conjugation; Reconfigurable architectures; Reconfigurable hardware; Conceptual study; Convolutional neural network; Freespace optics; Network-based; Optical neural networks; Optical-; Reconfigurable; Refresh rate; Smart pixels; Spatial light modulators; Light modulation | English | 2025 | 2025-03-20 | 10.3390/computers14030111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Correlation between electrical and structural changes in amorphous ITO films | We investigated the temperature-dependent resistance, structural properties, and chemical state of amorphous ITO film during annealing under vacuum using in-situ analyses. In-situ resistance measurement revealed a sharp increase in resistance, reaching a maximum at approximately 180 degrees C and decreasing with a further increase in annealing temperature. In-situ X-ray diffraction confirmed the onset of crystallization of the amorphous ITO film at the temperature where the resistivity increased sharply. From the in-situ XPS analysis, we found no change in chemical states, such as oxygen vacancy or the formation of Sn4+. In the Hall effect measurement, we confirmed a significant decrease in mobility at the ITO film annealed in vacuum at 175 degrees C. This indicates the grain boundaries formed by the crystallization of ITO increase the electron scattering, causing a sharp increase in resistance at 180 degrees C. Our findings suggest that structural changes primarily drove the change in electrical properties of amorphous ITO during annealing. This study highlights the importance of real-time monitoring in understanding the dynamic change in ITO film and provides a comprehensive understanding of the structural and electrical transitions during crystallization. | Han, Seonghoon; Son, Yeongjun; Song, Sehwan; Lee, Jisung; Bae, Jong-Seong; Pham, Anh Tuan Thanh; Phan, Thang Bach; Kim, Jeong Hwan; Ok, Jong Mok; Lee, Dooyong; Park, Sungkyun | Pusan Natl Univ, Dept Phys, Pusan 46241, South Korea; Korea Basic Sci Inst, Ctr Sci Instrumentat, Daejeon 34133, South Korea; Korea Basic Sci Inst, Yeongnam Reg Ctr, Pusan 46742, South Korea; Vietnam Natl Univ, Ho Chi Minh City 700000, Vietnam; Univ Sci, Lab Adv Mat, Ho Chi Minh City 700000, Vietnam; Ctr Innovat Mat & Architectures INOMAR, Ho Chi Minh City 700000, Vietnam; Hanbat Natl Univ, Dept Mat Sci & Engn, Daejeon 34158, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea; Pusan Natl Univ, Nucl Sci Res Inst, Busan 46241, South Korea; Pusan Natl Univ, Res Ctr Dielect & Adv Matter Phys, Pusan 46241, South Korea | Pham, Tuan Anh/JAX-8998-2023 | 57969341600; 58511002800; 57194115102; 57192440339; 7201386925; 59158918300; 56182322400; 55966663900; 55744462900; 56199505400; 10539429300 | leedy@knu.ac.kr; psk@pusan.ac.kr; | VACUUM | VACUUM | 0042-207X | 1879-2715 | 239 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 3.9 | 33.4 | 0 | 2025-06-11 | 0 | 0 | ITO; Resistance anomaly; Vacuum annealing; Crystallization; In-situ analysis | RAY PHOTOELECTRON-SPECTROSCOPY; TIN OXIDE-FILMS; OPTICAL-PROPERTIES; INDIUM; TRANSPARENT; RESISTIVITY; ENERGY | Crystallization; In-situ analysis; ITO; Resistance anomaly; Vacuum annealing | Chemical state; In-situ analysis; ITO; ITO films; Property; Resistance anomaly; Sharp increase; Situ resistance measurements; Temperature-dependent resistance; Vacuum-annealing; Amorphous films | English | 2025 | 2025-09 | 10.1016/j.vacuum.2025.114441 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Highly Efficient Low-Cost Flexible Neural Probe for Scalable Mass Fabrication | Neural probes capable of the precise recording and control of brain signals are essential tools for brain-computer interfaces and neuroscience research. However, conventional neural probes have not been widely adopted due to the high costs associated with semiconductor fabrication and complex packaging procedures. Herein, we present a breakthrough in this area in the form of a highly efficient flexible neural probe with a production cost of only 1.5 dollars per unit that can be mass-produced (1000 units within 3 days). The probe design is based on a standardized flexible printed circuit board (PCB) process that ensures large-scale producibility and minimizes device performance variation. The device features four independent neural probes that enable flexible targeting of multiple brain regions and a reusable interface PCB that minimizes packaging complexity. The neural signal recording performance of the fabricated probe is comparable to that of traditional silicon-based probes and is scalable with eight electrodes capable of simultaneous measurements. We anticipate that our innovative device will significantly improve the accessibility of neuroscience research. | Lee, Haeyun; Lee, Seungbin; Lee, Seungjun; Lee, Jimin; Chou, Namsun; Shin, Hyogeun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Korea Brain Res Inst KBRI, Emot Cognit & Behav Res Grp, Daegu 41062, South Korea | Chou, Namsun/AAS-3841-2020; 신, 효근/HSG-4622-2023 | 59663830000; 59682041100; 59664074300; 59663877100; 43061070600; 56591066700 | nschou@kbri.re.kr; hyogeunshin@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 10 | 10 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.3 | 33.7 | 2.41 | 2025-05-07 | 2 | 2 | SILICON PROBES; BRAIN; CIRCUITS; CELLS | English | 2025 | 2025-03-10 | 10.1021/acsomega.5c01419 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | A Novel Phaeoacremonium Species Isolated from Galls on the Chinese Magnolia-Vine (Schisandra chinensis) in Korea | The fungal strain KNUF-24-9L1a, belonging to the genus Phaeoacremonium, was isolated from gall-midge (Lasioptera sp.; Diptera: Cecidomyiidae) larvae and their galleries on a Chinese magnolia-vine (Schisandra chinensis) sample collected in Mungyeong-si, Gyeongbuk province, Korea. Phylogenetic analyses based on concatenated nucleotide sequences of the beta-tubulin and actin genes revealed that the strain clustered with Phaeoacremonium species but occupied a distinct phylogenetic position. Morphological differences between strain KNUF-24-9L1a and closely related species were also observed. In this study, we provide detailed descriptions, illustrations, and discussions of the morphological and phylogenetic analyses of closely related species to support the novelty of this isolated species. The phylogenetic and morphological evidence suggests that strain KNUF-24-9L1a represents a novel species within the genus Phaeoacremonium, which we have designated this species as Phaeoacremonium schisandrae sp. nov. | Lim, Seong-Keun; Azmi, Mohammad Hamizan; Kim, Min-Ki; Kim, Seung-Han; Lee, Seung-Yeol; Jung, Hee-Young | Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Gyeongbuk Agr Res & Extens Serv, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | 57756003900; 59208830200; 57226681143; 57202987824; 56106499600; 59510734500 | leesy1123@knu.ac.kr; | MYCOBIOLOGY | MYCOBIOLOGY | 1229-8093 | 2092-9323 | 53 | 2 | SCIE | AGRONOMY;MYCOLOGY | 2024 | 2 | 33.7 | 0 | 2025-05-07 | 0 | 0 | Morphology; phylogeny; Schisandra chinensis; gall-midge; Phaeoacremonium | PRIMER SETS; WOODY HOSTS; IDENTIFICATION; ASSOCIATION; RECORDS; FUNGUS; MIDGE | gall-midge; Morphology; Phaeoacremonium; phylogeny; Schisandra chinensis | English | 2025 | 2025-03-04 | 10.1080/12298093.2024.2438463 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Flexible Neural Probe with an Optimized Electrode Density for Neutral Investigations | Neural probes are essential tools for the study of neural networks and brain function. While silicon-based probes offer high-electrode density and precise recordings, their high fabrication cost and complex packaging requirements limit scalability and accessibility. Flexible neural probes utilizing flexible printed circuit board (FPCB) technology have emerged as a cost-effective alternative, but their low electrode density, attributed to process limitations, remains a challenge. Herein, we present a fabrication-optimized, flexible neural probe with enhanced electrode density. By optimizing line width and spacing, we considerably increased electrode density while maintaining compatibility with standard FPCB processes. A stiffener layer was incorporated to improve substrate planarity, and a 20% overetching technique was applied to enhance pattern fidelity and reliability. These optimizations tripled the recordable neural signals while maintaining high-signal quality, with a fabrication yield of 73% (200 samples). The fabricated probe demonstrated electrical and mechanical stability and successful in vivo neural recordings. This cost-effective, scalable probe improves accessibility for neuroscience research, particularly in resource-limited settings. This optimized neural probe will contribute to broader and more efficient neural network investigations. | Park, Sehwan; Lee, Haeyun; Kim, Minseok; Chou, Namsun; Shin, Hyogeun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Brain Res Inst KBRI, Emot Cognit & Behav Res Grp, Daegu 41062, South Korea | Chou, Namsun/AAS-3841-2020 | 59664022100; 59663830000; 59073001500; 43061070600; 56591066700 | nschou@kbri.re.kr; hyogeunshin@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 10 | 25 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.3 | 33.7 | N/A | 0 | 0 | LARGE-SCALE; TECHNOLOGY; POTENTIALS | English | 2025 | 2025-06-11 | 10.1021/acsomega.5c02700 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Fungal Endophyte from Lithophytic Plants Native to Basalt Coastal Dunes in Gimnyeong and Woljeong, Jeju Islands, Korea | This study aimed to establish a fungal symbiont culture collection for coastal dune conservation and determine the diversity and distribution of endophytic fungi in rocky coastal dunes at Gimnyeong and Woljeong in the Jeju Islands. Endophytic fungi can promote plant growth and induce systemic resistance to environmental stress and infections in host plants. The native plant species thriving in these habitats play a crucial role in preventing coastal erosion. A total of 138 fungal endophytes were isolated from two plant groups: basalt-dwelling lithophytes (83 isolates) and sandy soil-dwelling halophytes (55 isolates). The host plants belonged to nine orders, 11 families, 14 genera, and 14 species. Molecular identification and phylogenetic analysis based on internal transcribed spacer (ITS) regions classified the isolates into six fungal classes, 11 orders, 15 families, and 22 genera. The dominant classes were Sordariomycetes (51.45%), Eurotiomycetes (26.09%), Dothideomycetes (18.84%). The dominant genera were Penicillium (33.58%), Fusarium (16.79%), Aspergillus (15.33%), and Talaromyces (10.22%). Endophyte diversity, as measured by Shannon's diversity index (2.131), was higher in basalt-habitat lithophytes than in sandy soil-dwelling halophytes. However, no distinct pattern was observed in the variation of endophyte diversity or richness across plant life cycles (annual, perennial, or biennial species). | Park, Jong Myong; Hong, Ji Won; You, Young-Hyun | Waterworks Headquarters Incheon Metropolitan City, Water Qual Res Inst, Incheon, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu, South Korea; Natl Inst Biol Resources, Species Divers Res Div, ncheon, South Korea | Park, Jong Myong/D-5535-2014 | 54382161000; 57201579963; 53868615500 | rocer2404@korea.kr; | MYCOBIOLOGY | MYCOBIOLOGY | 1229-8093 | 2092-9323 | 53 | 4 | SCIE | AGRONOMY;MYCOLOGY | 2024 | 2 | 33.7 | 0 | 2025-06-11 | 0 | 0 | Basalt; coastal dune; endophyte; halophyte; lithophyte | GROWTH; DIVERSITY; BIOCONTROL; TOLERANCE; SYMBIOSIS; CLIMATE; ROOT | Basalt; coastal dune; endophyte; halophyte; lithophyte | English | 2025 | 2025-07-04 | 10.1080/12298093.2025.2502246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Isolation and Characterization of Four Unreported Penicillium Species Isolated from the Freshwater Environments in Korea | The fungal species of the genus Penicillium can be found across a diverse array of environments. The infrageneric classification of the genus Penicillium has been studied with comparison of morphological and phylogenetical features, derived into two subgenus, 32 sections, and 89 series. In this study, 11 fungal strains were isolated from freshwater environments, plant litter, and nearby substrates in Korea and were identified as previously unreported species. The internal transcribed spacer (ITS) regions, beta-tubulin (BenA), calmodulin (CaM), and RNA polymerase II subunit (RPB2) genes were analyzed for phylogenetic analyses. A neighbor-joining tree was then constructed using the concatenated DNA sequences, and the strains were compared with closely related species of the genus Penicillium. The strain clustered into distinct phylogenetic lineages, confirming their classification as P. contaminatum, P. jinfoshanicum, P. xuanhanense, and P. soppii. NNIBRFG40229 exhibits monoverticillate conidiophores with flask-shaped phialides, characteristic of P. contaminatum; NNIBRFG1595 presents divaricate conidiophores, consistent with P. jinfoshanicum; NNIBRFG5602 shows a velutinous texture with orange pigmentation, resembling P. xuanhanense; and NNIBRFG4602 shows biverticillate conidiophores with cylindrical metulae, corresponding to P. soppii. This study provides the first report of these species in Korea, enhancing taxonomic understanding. | Kim, Min-Gyu; Lim, Seong-Keun; Back, Chang-Gi; Oh, Yoosun; Cheon, Wonsu; Mun, Hye Yeon; Lee, Seung-Yeol; Jung, Hee-Young | Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Dankook Univ, Dept Environm Hort & Landscape Architecture, Environm Hort, Cheonan, South Korea; Nakdonggang Natl Inst Biol Resources, Fungi Res Div, Sangju, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | Mun, Hye Yeon/HKF-7311-2023 | 59631109500; 57756003900; 36144957400; 57203744491; 55792785800; 35211456500; 56106499600; 7403029383 | leesy1123@knu.ac.kr; | MYCOBIOLOGY | MYCOBIOLOGY | 1229-8093 | 2092-9323 | 53 | 3 | SCIE | AGRONOMY;MYCOLOGY | 2024 | 2 | 33.7 | 0 | 2025-05-07 | 0 | 0 | Morphological characteristics; Penicillium contaminatum; Penicillium jinfoshanicum; Penicillium soppii; Penicillium xuanhanense | EUROTIALES; TAXONOMY; IDENTIFICATION; ASPERGILLUS; TALAROMYCES; DIVERSITY; SERIES | Morphological characteristics; Penicillium contaminatum; Penicillium jinfoshanicum; Penicillium soppii; Penicillium xuanhanense | English | 2025 | 2025-05-04 | 10.1080/12298093.2025.2473141 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Machine-Learning Approach to Identify Organic Functional Groups from FT-IR and NMR Spectral Data | Interpreting spectral data to analyze the structure and properties of unknown chemicals requires a lot of time and effort. Herein, we developed a machine-learning model that simultaneously trains on multiple spectroscopic data to identify functional groups of compounds more accurately and quickly. An artificial neural network model trained on Fourier-transform infrared, proton nuclear magnetic resonance, and 13C nuclear magnetic resonance together identified 17 functional groups with a macro-average F1 score of 0.93, outperforming the model using a single type of spectroscopy. The results indicated that training a machine-learning model with multiple spectral data can provide more accurate structural analysis when analyzing the structure of unknown chemicals, as can using multiple spectroscopy methods simultaneously. | Lee, Gwanho; Shim, Hyekyoung; Cho, Juhyun; Choi, Sang-Il | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Choi, Sang-Il/N-7571-2013; Choi, Sangil/N-7571-2013 | 59701404100; 59700860000; 57198450723; 56167600800 | sichoi@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 10 | 12 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.3 | 33.7 | 0 | 2025-05-07 | 1 | 1 | MAGNETIC-RESONANCE SPECTRA; SAMPLE PREPARATION; IDENTIFICATION; TRENDS | English | 2025 | 2025-03-19 | 10.1021/acsomega.5c01903 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Microascus microspora sp. nov. and Tolypocladium terrae sp. nov.; Two Novel Fungal Species Isolated from Soil in Korea | During an investigation of microfungi from various ecosystems in South Korea, two novel fungal species (KNUF-22-094T and KNUF-23-321CT) were discovered within the genera Microascus and Tolypocladium. The strain KNUF-22-094T stands out among other Microascus species due to its distinctive conidiogenous cells and conidial size ranges. The conidiogenous cells of KNUF-22-094T measured 2.3-4.3 x 2.0-3.6 mu m, notably smaller than those of M. rothbergiorum (7.5-11.5 x 2.5-4.5 mu m), M. sparsimycelialis (5.0-10.0 x 3.0-5.0 mu m), which is considerably larger in both dimensions. For the conidial structures, conidia measured 2.6-4.8 x 2.6-4.4 mu m, falling within a distinct range that is smaller than those of M. rothbergiorum (4.0-5.5 x 3.5-4.5 mu m), M. verrucosus (5.0-7.0 x 4.5-6.0 mu m), and M. restrictus (4.5-6.0 x 4.0-5.5 mu m), but comparable in size to M. murinus, which tends to be more elongated (4.0-6.0 x 1.5-1.9 mu m). The phialides of KNUF-23-321CT are globose, with a notably broad length range of 3.7-22.5 mu m and a width of 0.9-1.5 mu m, making it one of the most variable in length compared to species like T. album (3.5-10 mu m) and T. endophyticum (1.3 +/- 0.2 mu m, 4.1 mu m on average). Phylogenetic analyses using a multi-locus sequences supported to confirm their distinctness under the genus Microascus and Tolypocladium species. Thus, these fungal strains isolated from soil in Korea are proposed as a novel species according to their characteristics and are named Microascus microspora sp. nov. and Tolypocladium terrae sp. nov. Detailed descriptions, illustrations, and phylogenetic data are provided to support the recognition of these new species. | Lim, Seong-Keun; Kallol, Das; Choi, Jun-Woo; Kim, Min-Gyu; Back, Chang-Gi; Kang, In-Kyu; Lee, Seung-Yeol; Jung, Hee-Young | Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Calif Polytech State Univ San Luis Obispo, Dept Wine & Viticulture, San Luis Obispo, CA USA; Dankook Univ, Dept Environm Hort & Landscape Architecture, Cheonan, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | 57756003900; 59707052100; 59213079300; 59631109500; 36144957400; 59349261900; 56106499600; 7403029383 | leesy1123@knu.ac.kr; | MYCOBIOLOGY | MYCOBIOLOGY | 1229-8093 | 2092-9323 | 53 | 3 | SCIE | AGRONOMY;MYCOLOGY | 2024 | 2 | 33.7 | 0 | 2025-05-07 | 0 | 0 | Morphology; Microascus; phylogeny; Tolypocladium; soil | DNA-SEQUENCES; IDENTIFICATION; NUCLEAR | Microascus; Morphology; phylogeny; soil; Tolypocladium | English | 2025 | 2025-05-04 | 10.1080/12298093.2025.2474291 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Scytalidium terrigenum sp. nov., a New Species Isolated from Soil in Korea | During an investigation of soil microfungi in Korea, a fungal strain designated KNUF-23-236 was isolated from a soil sample collected in Seocheon-gun, Chungcheongnam-do, Korea. Molecular analyses using the ITS regions and the LSU, SSU, and RPB2 genes revealed that Scytalidium aurantiacum and Scytalidium album are its close phylogenetic relatives, with sequence similarity levels ranging from 93.8% to 100.0%. However, based on cultural and morphological characteristics strain KNUF-23-236 differs from S. aurantiacum and S. album by having white-to-yellow colonies without reddish pigmentation, smaller hyphae (1.4-3.4 mu m vs. 1.6-4.8 mu m and 3.2-8.0 mu m, respectively), arthrospores that transition from hyaline to brown rather than remaining consistently hyaline, and oval, septate chlamydospores that form singly or in chains, without branching. Furthermore, the phylogenetic trees constructed using the ITS sequence alone, the concatenated ITS and LSU sequences, and the combined sequences of three loci (ITS, SSU, and RPB2) confirmed a distinct phylogenetic position of KNUF-23-236 within the genus Scytalidium. Based on a combination of phylogenetic and morphological evidence, strain KNUF-23-236 is identified as a novel species of the genus, for which the name Scytalidium terrigenum sp. nov. is proposed. | Jeong, Yeon-Su; Lim, Seong-Keun; Nam, Song-Woon; Ten, Leonid N.; Lee, Seung-Yeol; Jung, Hee-Young | Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | ; Ten, Leonid/P-7941-2014 | 59726103600; 57756003900; 58971728000; 6603039265; 56106499600; 7403029383 | heeyoung@knu.ac.kr; | MYCOBIOLOGY | MYCOBIOLOGY | 1229-8093 | 2092-9323 | 53 | 3 | SCIE | AGRONOMY;MYCOLOGY | 2024 | 2 | 33.7 | 0 | 2025-05-07 | 0 | 0 | Scytalidium sp. nov.; soil-inhabiting fungi; morphological analysis; molecular phylogeny | METABOLITES | molecular phylogeny; morphological analysis; Scytalidiumsp. nov; soil-inhabiting fungi | English | 2025 | 2025-05-04 | 10.1080/12298093.2025.2479241 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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