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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Article ⓘ Design and Application of Piezoelectric Conductive Smart Scaffold for Noninvasive Neural Tissue Regeneration via Custom-Made In Vitro Mechano-Stimulator ⓘ Peripheral nerve injuries frequently result in long-term functional disability and sensory loss due to the lack of appropriate treatment options. Autologous nerve transplantation is currently the gold standard for repairing damaged nerves, but the increased risk of neuroma formation is the most significant issue with this approach. Moreover, the lack of effective treatment methods that allow for simple and clinically significant neural-tissue electrical stimulation has also restricted full functional nerve recovery. To circumvent these limitations, this study devises an electrospun nanofiber-based piezoelectric and conductive nerve conduit (PCNC) that can self-generate electrical stimulations analogous to neural tissues. This work also focuses on designing a low-cost, customizable 3D printed bioreactor to deliver controlled dynamic compressive loading on cell-cultured piezoelectric nanocomposite constructs. By using a custom-designed mechano-stimulator in conjunction with PCNC, the invitro biocompatibility and neuronal differentiation of the PC12 cells are investigated. The results evidence the expression of increased neurogenic differentiation markers from the stimulated PCNC group compared to the unstimulated PCNC control group. When wrapped around a damaged nerve and remotely activated by dynamic mechanical stimulation, this PCNC can give in situ topographical and electrical cues for optimal nerve regeneration due to its unique structure, composition, piezoelectric, and conducting capabilities. © 2025 The Author(s). Advanced NanoBiomed Research published by Wiley-VCH GmbH. ⓘ Rajan Unnithan, Afeesh; Krishnamoorthi Kaliannagounder, Vignesh; Rao Alluri, Nagamalleswara; Park, Chan Hee; Veluswamy, Pandiyarasan; Ramachandra Kurup Sasikala, Arathyram ⓘ Centre for Pharmaceutical Engineering Science, School of Pharmacy and Medical Sciences, Faculty of Lifesciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, United Kingdom; School of Engineering, Newcastle University, Claremont Road, Newcastle upon Tyne, NE1 7RU, United Kingdom; Research Institute of Automotive Parts and Materials, School of Materials Science and Metallurgical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, South Korea; Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju, 561-756, South Korea, Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju, 54896, South Korea; SMart and Innovative Laboratory for Energy Devices, Indian Institute of Information Technology Design and Manufacturing, Tamilnadu, Kancheepuram, Chennai, 600127, India; Centre for Pharmaceutical Engineering Science, School of Pharmacy and Medical Sciences, Faculty of Lifesciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, United Kingdom ⓘ ⓘ 55124980700; 57835367600; 57208247514; 59907884300; 55749575200; 58964541900 ⓘ a.rajanunnithan@bradford.ac.uk; a.ramachandrakurupsasikala@bradford.ac.uk; ⓘ Advanced NanoBiomed Research ⓘ ADV NANOBIOMED RES ⓘ 2699-9307 2699-9307 ESCI ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS;NANOSCIENCE & NANOTECHNOLOGY ⓘ 2024 4.4 32.7 ⓘ 0 ⓘ ⓘ electrospinning; mechanoelectrical stimulation; nerve conduits; neural; piezoelectricity; regeneration ⓘ ⓘ English Article in press 2025 10.1002/anbr.202500058 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Enhancing thermal and mechanical properties of rigid polyurethane foam with eco-friendly silane-modified cellulose nanocrystals ⓘ Cellulose nanocrystals (CNC) are promising candidates for strengthening polymeric matrices, offering unique features like biodegradability, renewability, and exceptional mechanical properties. However, efficiently dispersing CNC in these matrices and finely adjusting their interfacial characteristics are critical for harnessing their full potential in novel nanomaterial development. Herein, we developed novel eco-friendly and effective method to modify the surface of the CNC with three types of silane coupling agents - (3-Aminopropyl trimethoxysilane (APTMS), N-ethyl-2,2-dimethoxy-4-methyl-1-aza-2-silacyclopentane (ASCP1), and N-(2-aminoethyl)-2,2,4-trimethyl-1-aza-2-silacyclopentane (ASCP2) by using chemical vapor deposition (CVD). The sustainable rigid polyurethane foams (RPUFs) were then prepared by incorporating three modified CNCs (CNCAPTMS, CNC-ASCP1, and CNC-ASCP2) from 0.5 to 5 wt%. Afterward, the influence of these three modified CNCs with increasing content on the morphology, thermal, and compressive properties of RPUFs was examined. It was observed that the RPUFs containing 0.5 wt% and 1 wt% of CNC-ASCP2 exhibited a lower thermal conductivity (0.043 +/- 0.002 and 0.045 +/- 0.001 W/m center dot K, respectively) compared to standard RPUF sample (0.049 +/- 0.005 W/ m center dot K). Furthermore, these foams also showed enhanced compressive strength (1.96 +/- 0.08 and 2.03 f 0.5 MPa) in comparison to the standard RPUF sample (1.25 +/- 0.09 MPa). This improvement in thermal and compressive properties is attributed to the better compatibility of CNC-ASCP2 with polyol and foam components, promoting efficient nucleation of cells and uniform dispersion within the foam. ⓘ Saddique, Anam; Han, Kyung Rok; Kim, Taekyeong; Joo, Jin; Cheong, In Woo ⓘ Kyungpook Natl Univ, Dept Appl Chem, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Text Syst Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ⓘ 57312386800; 58848736900; 24587275700; 57189617034; 7006733373 ⓘ jinjoo@knu.ac.kr; inwoo@knu.ac.kr; ⓘ COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS ⓘ COLLOID SURFACE A ⓘ 0927-7757 1873-4359 704 SCIE CHEMISTRY, PHYSICAL ⓘ 2024 5.4 32.7 0 2025-05-07 ⓘ 1 1 Cellulose nanocrystals; Chemical vapor deposition; Cyclic silane coupling agents; Rigid polyurethane foam ⓘ SURFACE MODIFICATION; CONDUCTIVITY; FIBERS; FUNCTIONALIZATION; HYDROGEL; BEHAVIOR ⓘ Cellulose nanocrystals; Chemical vapor deposition; Cyclic silane coupling agents; Rigid polyurethane foam ⓘ Cellulose Derivatives; Compression Strength; Coupling Agents; Foam; Matrices; Mechanical Properties; Standards; Bending moments; Cellulose; Cellulose derivatives; Cellulose nanocrystals; Coupling agents; Hydroelasticity; Nanoclay; Rigid foamed plastics; Strain rate; 3 aminopropyl trimethoxysilane; cellulose nanocrystal; n (2 aminoethyl) 2,2,4 trimethyl 1 aza 2 silacyclopentane; n ethyl 2,2 dimethoxy 4 methyl 1 aza 2 silacyclopentane; polyurethan foam; rigid polyurethane foam; silane derivative; unclassified drug; Chemical vapour deposition; Compressive properties; Cyclic silane coupling agent; Eco-friendly; Modified cellulose; Polymeric matrices; Rigid polyurethane foams; Silane-coupling agents; Thermal; Thermal and mechanical properties; Article; biocompatibility; chemical vapor deposition; comparative study; compressive strength; controlled study; degree of substitution; dispersion; Fourier transform infrared spectroscopy; green chemistry; heat; heat tolerance; mechanics; micromorphology; molecular weight; photon correlation spectroscopy; scanning electron microscopy; standard; surface property; synthesis; temperature related phenomena; thermal conductivity; thermal insulation; thermogravimetry; thermostability; transmission electron microscopy; X ray diffraction; X ray photoemission spectroscopy; Compressive strength ⓘ English 2025 2025-01-05 10.1016/j.colsurfa.2024.135443 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Formation of ring-shape microparticles with controlled shapes by manipulating the internal flow in microdroplets ⓘ In the field of tissue engineering, a porous scaffold plays a crucial role in facilitating optimal nutrient and waste circulation during cell growth. This study proposes a fabrication method for microring particles with controlled shapes using a microfluidic system that precisely regulates the internal flow in microdroplets during the collection process. To determine the mechanism governing microring particle formation, a rotating collection system that applies centrifugal force while inhibiting the stirred flow of the collection phase was implemented. Consequently, the internal flow in microdroplets, until solvent evaporation, emerges as a critical factor in shaping microparticles. In this investigation, various experimental conditions, including stirring rate, temperature, and collection types, were systematically analyzed to elucidate the factors influencing the formation of microparticles. The generated porous particles were classified into five distinct types: porous, large-pore, ring, pocket-shaped, and dish-shaped particles. The morphology of these particles was observed using optical inverted microscope and field-emission scanning electron microscope(FE-SEM). To investigate their penetration properties based on shape, a comparative analysis was conducted by injecting solid, porous, and ring particles into a gradually narrowing microchannel. In addition, water was introduced at their respective stacked volumes within the microchannel to compare flow resistance according to their shapes. ⓘ Han, Ji Hwan; Kim, Chul Min; Kim, Tae Hyun; Choi, Jin Ho; Kim, Gyu Man ⓘ Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro,Bukgu, Bukgu 41566, Daegu, South Korea; Gyeongsang Natl Univ, Dept Mechatron Engn, Jinju, South Korea; R&D Ctr, Tissue Engn Bio Sci, Yangsan, South Korea; KIFLEX CO, Gyongsan, South Korea ⓘ Kim, Chul-Min/ABI-6131-2020; Ko, Jae-Hyeon/I-4133-2019 ⓘ 58132023300; 59316640400; 58132612200; 59040049800; 55664733000 ⓘ gyuman.kim@knu.ac.kr; ⓘ COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS ⓘ COLLOID SURFACE A ⓘ 0927-7757 1873-4359 708 SCIE CHEMISTRY, PHYSICAL ⓘ 2024 5.4 32.7 0 2025-05-07 ⓘ 1 1 Microfluidics; Microfabrication; Microring; Particle geometry; Tissue engineering ⓘ POROUS SCAFFOLDS; MICROSPHERES; FABRICATION; PARTICLES ⓘ Microfabrication; Microfluidics; Microring; Particle geometry; Tissue engineering ⓘ Cell engineering; Drops; Field emission microscopes; Fluidic logic devices; Microfabrication; Microfluidics; Scaffolds; Scaffolds (biology); camphene; polymer; polyvinyl alcohol; solvent; water; Controlled shape; Fabrication method; Internal flows; Micro droplets; Micro particles; Micro-fabrication; Microrings; Particle geometries; Porous scaffold; Tissues engineerings; Article; computer simulation; drug delivery system; evaporation; field emission scanning electron microscopy; flow; magnetism; medical research; microfluidics; microtechnology; nutrient; shear rate; temperature; tissue engineering; waste; water supply; Tissue ⓘ English 2025 2025-03-05 10.1016/j.colsurfa.2024.135918 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Bounding the intersection number c2 of a distance-regular graph with classical parameters (D,b,α,β) in terms of b ⓘ Let Γ be a distance-regular graph with classical parameters (D,b,α,β) and b≥1. It is known that Γ is Q-polynomial with respect to θ1, where θ1=[Formula presented]−1 is the second largest eigenvalue of Γ. And it was shown that for a distance-regular graph Γ with classical parameters (D,b,α,β), D≥5 and b≥1, if a1 is large enough compared to b and Γ is thin, then the intersection number c2 of Γ is bounded above by a function of b. In this paper, we obtain a similar result without the assumption that the graph Γ is thin. © 2024 Elsevier B.V. ⓘ Koolen, Jack H.; Lv, Chenhui; Park, Jongyook; Yang, Qianqian ⓘ School of Mathematical Sciences, University of Science and Technology of China, 96 Jinzhai Road, Anhui, Hefei, 230026, China, CAS Wu Wen-Tsun Key Laboratory of Mathematics, University of Science and Technology of China, 96 Jinzhai Road, Anhui, Hefei, 230026, China; School of Mathematical Sciences, University of Science and Technology of China, 96 Jinzhai Road, Anhui, Hefei, 230026, China; Department of Mathematics, Kyungpook National University, Daegu, 41566, South Korea; Department of Mathematics, Shanghai University, Shanghai, 200444, China, Newtouch Center for Mathematics of Shanghai University, Shanghai, 200444, China ⓘ ⓘ 7004991766; 57209419274; 36091826300; 57193194366 ⓘ jongyook@knu.ac.kr; ⓘ Discrete Mathematics ⓘ DISCRETE MATH ⓘ 0012-365X 1872-681X 348 2 SCIE MATHEMATICS ⓘ 2024 0.9 32.8 0 2025-05-07 ⓘ 0 ⓘ ⓘ Classical parameters; Cliques; Distance-regular graphs; Eigenvalues ⓘ ⓘ English Final 2025 10.1016/j.disc.2024.114239 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Impact of renal function on treatment strategies and clinical outcomes in acute myocardial infarction patients with multivessel disease ⓘ Objective: The impact of renal function on revascularization outcomes in patients with acute myocardial infarction and multivessel disease remains unclear. This study compared long-term outcomes of complete (CR) and incomplete revascularization (IR) in patients with estimated glomerular filtration rate (eGFR) ≥60 or <60 mL/min/1.73 m2 Methods: Using data from the Korea Acute Myocardial Infarction Registry-National Institute of Health, 5962 patients (mean age: 65.4 ± 12.1 years; 4389 men) were categorized by renal function into Group I (eGFR ≥60, n = 4689) and Group II (eGFR <60, n = 1273). Each group was divided into CR (IA, IIA) and IR (IB, IIB) subgroups. The primary end point was the incidence of major adverse cardiac events (MACEs), a composite of all-cause death, myocardial infarction, and repeat revascularization, assessed over a 3-year follow-up. Results: MACEs were more frequent in Group II than Group I (41.5% vs. 19.4%, p < 0.001). In Group I, CR reduced MACEs compared with IR (16.7% vs. 22.6%, p < 0.001). However, no significant difference was found between CR and IR in Group II (p = 0.118). Key predictors of MACEs included advanced age, diabetes, prior myocardial infarction, ST-elevation myocardial infarction, and IR. Conclusion: CR improved outcomes in patients with eGFR ≥60, whereas no difference was observed between CR and IR in those with eGFR <60. Therefore, IR may be a viable option for patients with reduced renal function. © 2025 Hellenic Society of Cardiology ⓘ Park, Seongho; Park, Eun Ju; Lee, Seung Hun; Ahn, Joon Ho; Lee, Yong-Kyu; Joo, Donghyeon; Cho, Kyung Hoon; Kim, Min Chul; Sim, Doo Sun; Lee, Joo Myung; Song, Young Bin; Hahn, Joo-Yong; Chae, Shung Chull; Kim, Chong Jin; Hong, Young Joon; Kim, Ju Han; Gwon, Hyeon-Cheol; Kim, Hyo-Soo; Ahn, Youngkeun; Jeong, Myung Ho ⓘ Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea; Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea ⓘ ⓘ 59674849600; 59674658600; 57214839313; 59673893300; 58128505000; 58544592200; 55595842500; 57202224572; 7006825347; 54894745500; 15763569500; 12771661800; 7101962036; 35229511500; 13310329100; 57196169644; 6603262426; 58843097000; 59309496700; 59716263300 ⓘ myungho@bohun.or.kr; ⓘ Hellenic Journal of Cardiology ⓘ HELL J CARDIOL ⓘ 1109-9666 2241-5955 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS ⓘ 2024 3 32.8 0 2025-05-07 ⓘ 0 ⓘ ⓘ Coronary artery disease; Myocardial infarction; Renal function; Revascularization ⓘ ⓘ English Article in press 2025 10.1016/j.hjc.2025.02.001 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Inherent Lattice Distortion Engineering via Magnetic Field for High-Quality Strained MAPbI3 Perovskite Single Crystals ⓘ Lattice distortion in perovskites (AMX3) significantly impacts their stability and power conversion efficiency, often in a trade-off. The inherent lattice distortion is predominantly influenced by the size, orientation, and composition of the A-site cations. Notably, organic-inorganic hybrid lead halide perovskites with organic cations like methylammonium (MA) and formamidinium (FA) demonstrate high power conversion efficiency but compromised stability. Here, a novel synthesis method is presented for high-quality strained MAPbI3 single crystals that offers not only enhanced optoelectronic properties but also improved thermal stability. This technique leverages the paramagnetic nature of the MA+ ion to manipulate lattice distortion. During the inverse temperature crystallization process, the dipole moment of the MA+ ion aligns with the direction of the external magnetic field. Correlating Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis demonstrates that this alignment, which induces compressive lattice strain, significantly enhances the carrier mobility from 68.1 to 487 cm2 V s-1, representing a sevenfold increase in hole mobility compared to the control sample. Additionally, it increases the carrier lifetime by 123%, from 23.458 to 52.364 ns, and improves thermal stability up to 230 degrees C. This findings reveal insights into the interplay between structural modifications and electronic properties, paving the way for tailored applications in photovoltaics, light-emitting devices, and beyond. ⓘ Ogunleye, Abdulazeez M.; Lee, Hakseon; Awwal, Adeshina Mohammad; Kim, Gunwoo; Kim, Hyunmin; Choi, Yoonmi; Park, Jonghoo ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Div Biotechnol, Daegu 42988, South Korea; Korea Res Inst Chem Technol KRICT, Chem Anal Ctr, Daejeon 34114, South Korea ⓘ ⓘ 57933554600; 57734054800; 59422417500; 59422417600; 57192552925; 57193321328; 57196408322 ⓘ ymchoi@krict.re.kr; jonghoopark@knu.ac.kr; ⓘ ADVANCED MATERIALS INTERFACES ⓘ ADV MATER INTERFACES ⓘ 2196-7350 12 9 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 4.4 32.8 0 2025-05-07 ⓘ 1 1 magnetic field-assisted ITC; octahedral distortion; perovskite single crystals; strained perovskite; thermal stability ⓘ SOLAR-CELL; CH3NH3PBI3; GROWTH ⓘ magnetic field-assisted ITC; octahedral distortion; perovskite single crystals; strained perovskite; thermal stability ⓘ Lattice vibrations; Perovskite solar cells; Signal receivers; Surface discharges; Distortion engineerings; High quality; Lattice distortions; Magnetic field-assisted ITC; Magnetic-field; Octahedral distortion; Perovskite single crystal; Power conversion efficiencies; Strained perovskite; Thermal; Hole mobility ⓘ English 2025 2025-05 10.1002/admi.202400781 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Non-existence of two infinite families of strongly regular graphs ⓘ For a positive integer t, a putative strongly regular graph G with parameters (n, k, lambda, mu) = (1 + k + k(k-1-lambda) mu , 2t(4t + 1)mu, (2t + 1)(32t3 + 4t - 1), (2t + 1)(8t2 + 1)) satisfies both the Krein condition and the absolute bound. Also the multiplicities of the eigenvalues of the graph G are integers. This may mean that such a strongly regular graph exists. However, Koolen and Gebremichel proved that such a strongly regular graph does not exist for t = 1. In this paper, we generalize their method for all t >= 1 and rule out the infinite family of such strongly regular graphs. In order to do so, we find a restriction on the orders of two large maximal cliques intersecting in many vertices. And we also look at the case where the equality of the claw-bound holds to find an upper bound on the order of a coclique in a local graph (when G is not Terwilliger). In a similar fashion, we note that one can also rule out another infinite family of putative strongly regular graphs with parameters (n, k, lambda, mu) = (1+k+ k(k-1-lambda) mu , (2t+ 1)(4t + 3)mu, (2t + 2)(32t3 +64t2 +44t+ 9), (2t + 2)(8t2 + 12t + 5)). With the generalized method we are able to rule out two infinite families of putative strongly regular graphs. We are sure that this generalized method can be applied to rule out more putative strongly regular graphs. '(c) 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. ⓘ Koolen, Jack H.; Gebremichel, Brhane; Park, Jeong Rye; Park, Jongyook ⓘ Univ Sci & Technol China, Sch Math Sci, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China; Univ Sci & Technol China, CAS Wu Wen Tsun Key Lab Math, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China; Adigrat Univ, Dept Math, Adigrat, Tigray, Ethiopia; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea ⓘ Park, Jeong Rye/MDS-8129-2025 ⓘ 7004991766; 57219508592; 56471031400; 36091826300 ⓘ koolen@ustc.edu.cn; brhane@ustc.edu.cn; parkjr@knu.ac.kr; jongyook@knu.ac.kr; ⓘ EUROPEAN JOURNAL OF COMBINATORICS ⓘ EUR J COMBIN ⓘ 0195-6698 1095-9971 126 SCIE MATHEMATICS ⓘ 2024 0.9 32.8 0 2025-05-07 ⓘ 0 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-05 10.1016/j.ejc.2025.104121 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Pseudo-Ricci-Bourguignon solitons on real hypersurfaces in the complex hyperbolic space ⓘ In this paper, we give a complete classification of pseudo-Ricci-Bourguignon soliton on real hypersurfaces in the complex hyperbolic space ℂHn = SU1,n/S(U1Un). Next as an application we give a complete classification of gradient pseudo-Ricci-Bourguignon soliton on Hopf real hypersurfaces in the complex hyperbolic space ℂHn. © 2025, University of Nis. All rights reserved. ⓘ Hwang, Doo Hyun; Kim, Gyu Jong; Lee, Hyunjin ⓘ Research Institute of real and Complex Manifolds (RIRCM), Kyungpook National University, Daegu, 41566, South Korea; Department of Applied Mathematics, Pukyong National University, Busan, 48547, South Korea; Department of Mathematics Education, Chosun University, Gwangju, 61452, South Korea, Department of Mathematics, Kyungpook National University, Daegu, 41566, South Korea ⓘ ⓘ 56677222700; 56204082600; 55706812200 ⓘ lhjibis@hanmail.net; ⓘ Filomat ⓘ FILOMAT ⓘ 0354-5180 0354-5180 39 12 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2024 0.9 32.8 0 2025-06-11 ⓘ 0 ⓘ ⓘ complex hyperbolic space; gradient pseudo-Ricci-Bourguignon soliton; pseudo-Einstein; pseudo-Ricci-Bourguignon soliton ⓘ ⓘ English Final 2025 10.2298/fil2512931h ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ η-∗Einstein Hopf real hypersurfaces in the complex space forms ⓘ Einstein's metrics and their generalizations have attracted the attention of Mathematicians due to their applications in physics and other natural sciences. The generalization of Einstein metrics is Ricci solitons, eta-Einstein metrics, pseudo-Einstein metrics, and Miao-Tam critical metrics. Given the established non-existence of Einstein real hypersurfaces in a non-flat complex space form (M) over cap (n)(c) [2, 13], motivated our investigation into the properties of eta-(& lowast;)Einstein real hypersurface in (M) over cap (n)(c). In this paper, we examine the eta-(& lowast;)Einstein Hopf real hypersurface in the complex space form. We prove that there exist eta-(& lowast;)Einstein Hopf real hypersurfaces. ⓘ Rani, Savita; Gupta, Ram Shankar; Suh, Young Jin ⓘ Tata Inst Fundamental Res, Int Ctr Theoret Sci, Dept Math, Bengaluru 560089, India; Guru Gobind Singh Indraprastha Univ, Univ Sch Basic & Appl Sci, Sect 16C Dwarka, New Delhi 110078, India; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Real & Complex Manifolds, Daegu 41566, South Korea ⓘ Rani, Savita/GQY-7897-2022; GUPTA, RAM SHANKAR/GXF-1637-2022 ⓘ 57609444500; 8551352900; 57205268556 ⓘ mansavi.14@gmail.com; ramshankar.gupta@gmail.com; yjsuh@knu.ac.kr; ⓘ FILOMAT ⓘ FILOMAT ⓘ 0354-5180 39 10 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2024 0.9 32.8 0 2025-05-07 ⓘ 0 0 Gradient Ricci soliton; eta-(& lowast;)Einstein; complex space form; contact hypersurface; Hopf real hypersurface ⓘ RICCI SOLITONS ⓘ complex space form; contact hypersurface; Gradient Ricci soliton; Hopf real hypersurface; η-<sup>∗</sup> Einstein ⓘ ⓘ English 2025 2025 10.2298/fil2510227r ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea ⓘ Background: Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods: This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens, basic patient characteristics, clinical features, and the factors associated with infections by potentially drug-resistant (PDR) pathogens using various microbiological tests. Results: Bacteria, viruses, and both were detected in 262 (22.1%), 265 (22.5%), and 129 (10.9%) of patients, respectively. The most common pathogens included Pseudomonas aeruginosa (17.8%), Mycoplasma pneumoniae (11.2%), Streptococcus pneumoniae (9.0%), influenza A virus (19.0%), rhinovirus (15.8%), and respiratory syncytial virus (6.4%). Notably, a history of pulmonary tuberculosis (odds ratio [OR], 1.66; p=0.046), bronchiectasis (OR, 1.99; p=0.032), and the use of a triple inhaler regimen within the past 6 months (OR, 2.04; p=0.005) were identified as significant factors associated with infection by PDR pathogens. Moreover, patients infected with PDR pathogens exhibited extended hospital stays (15.9 days vs. 12.4 days, p=0.018) and higher intensive care unit admission rates (15.9% vs. 9.5%, p=0.030). Conclusion: This study demonstrates that a variety of pathogens are involved in episodes of AECOPD. Nevertheless, additional research is required to confirm their role in the onset and progression of AECOPD. ⓘ Ji, Hyun Woo; Yu, Soojoung; Sim, Yun Su; Seo, Hyewon; Park, Jeong-Woong; Min, Kyung Hoon; Kim, Deog Kyeom; Lee, Hyun Woo; Rhee, Chin Kook; Park, Yong Bum; Shin, Kyeong-Cheol; Ha Yoo, Kwang; Jung, Ji Ye ⓘ Yonsei Univ, Severance Hosp, Dept Internal Med, Div Pulm & Crit Care Med,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Soonchunhyang Univ, Seoul Hosp, Int Healthcare Ctr, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Dept Internal Med, Seoul 150950, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Incheon, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Seoul, South Korea; Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; Yeungnam Univ, Med Ctr, Div Pulmonol & Allergy, Dept Internal Med,Coll Med, Daegu, South Korea; Konkuk Univ, Sch Med, Dept Internal Med, 120-1 Neungdongro, Seoul 05030, South Korea ⓘ Min, Kyung Hoon/C-5984-2019; Min, Kyung/C-5984-2019; Rhee, Chin Kook/P-8885-2018 ⓘ 57388574500; 58040623100; 8879185900; 55612130200; 56746443700; 57077706300; 57219957699; 57205720858; 59716201000; 57212764499; 35320479500; 57693301700; 57226035040 ⓘ khyou@kuh.ac.kr; stopyes@yuhs.ac; ⓘ TUBERCULOSIS AND RESPIRATORY DISEASES ⓘ TUBERC RESPIR DIS ⓘ 1738-3536 2005-6184 88 2 ESCI RESPIRATORY SYSTEM ⓘ 2024 3 32.9 0 2025-05-07 ⓘ 0 0 Chronic Obstructive Pulmonary Disease; Acute Exacerbation; Pathogen; Drug Resistance ⓘ OBSTRUCTIVE PULMONARY-DISEASE; RISK-FACTORS; RESISTANT PATHOGENS; BACTERIAL; SPUTUM; BRONCHIECTASIS; INFLAMMATION; ANTIBIOTICS; INFECTIONS; PREVALENCE ⓘ Acute Exacerbation; Chronic Obstructive Pulmonary Disease; Drug Resistance; Pathogen ⓘ beta adrenergic receptor stimulating agent; beta lactam antibiotic; bronchodilating agent; corticosteroid; long acting drug; macrolide; muscarinic receptor blocking agent; quinolone; steroid; acute exacerbation of chronic obstructive pulmonary disease; Adenoviridae; adenovirus infection; aged; Article; bacterium detection; Bocaparvovirus; Bocavirus infection; Bordetella pertussis; bronchiectasis; Chlamydia pneumoniae; chlamydial pneumonia; chronic obstructive lung disease; clinical feature; clinical significance; coinfection; controlled study; Coronavirinae; Coronavirus infection; Enterovirus; Enterovirus infection; female; Haemophilus influenzae; Haemophilus influenzae infection; hospital admission; human; Human respiratory syncytial virus; human tissue; influenza A; Influenza A virus; influenza B; Influenza B virus; intensive care unit; Klebsiella pneumoniae; Klebsiella pneumoniae infection; Legionella pneumophila; legionnaire disease; length of stay; lung tuberculosis; major clinical study; male; medical history; Metapneumovirus; Metapneumovirus infection; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; Moraxella catarrhalis; Moraxella infection; Mycoplasma pneumoniae; Mycoplasma pneumoniae infection; nonhuman; Parainfluenza virus infection; Paramyxovirinae; pertussis; pneumococcal infection; prevalence; Pseudomonas aeruginosa; Pseudomonas infection; respiratory syncytial virus infection; respiratory tract infection; retrospective study; Rhinovirus; Rhinovirus infection; South Korea; Staphylococcus aureus; Staphylococcus aureus infection; Stenotrophomonas maltophilia; Streptococcus pneumoniae; virus detection ⓘ English 2025 2025-04 10.4046/trd.2024.0089 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Effects of Temperature on the Microbial Growth and Quality of Unsealed Dry Pet Food during Storage ⓘ Dry pet food is a convenient option for pet owners, but its storage conditions can impact its microbial growth and quality. In this study, we examined the effects of storage temperature on the quality and microbial growth of dry pet food. The pet food was stored at 25 degrees C and 35 degrees C, respectively, and samples were analyzed on days 0, 30, 90, and 120 for microbial growth and quality attributes such as pH, color, lipid oxidation, and volatile basic nitrogen. While no initial microbial growth was observed due to the low water content and water activity, quality attributes showed changes over time. However, the changes were negligible, indicating that dry pet food remains feedable for up to 120 days even at a storage temperature of 35 degrees C. These findings suggest that dry pet food can be safely stored at room temperature or up to 35 degrees C without compromising its quality. ⓘ Park, Dongbin; Lee, Hyun Jung; Sethukali, Anand Kumar; Yim, Dong-Gyun; Park, Sungkwon; Jo, Cheorun ⓘ Seoul Natl Univ, Ctr Food & Bioconvergence, Dept Agr Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Univ Jaffna, Fac Agr, Dept Anim Sci, Kilinochchi 44000, Sri Lanka; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Sejong Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seoul 05006, South Korea; Seoul Natl Univ, Inst Green Bio Sci & Technol, Pyeongchang 25354, South Korea ⓘ ; Jo, Cheorun/D-5724-2014 ⓘ 58318579400; 57209160167; 58319068900; 56727813800; 59725731400; 59786288400 ⓘ cheorun@snu.ac.kr; ⓘ FOOD SCIENCE OF ANIMAL RESOURCES ⓘ FOOD SCI ANIM RESOUR ⓘ 2636-0772 2636-0780 45 2 SCIE FOOD SCIENCE & TECHNOLOGY ⓘ 2024 3.7 32.9 10.04 2025-05-07 ⓘ 1 2 dry pet food; storage temperature; microbial growth; quality ⓘ WATER ACTIVITY; MAILLARD REACTION; NATURAL ANTIOXIDANTS; STABILITY; OXIDATION; WASTE; COLOR; FEED; OIL; PH ⓘ dry pet food; microbial growth; quality; storage temperature ⓘ ⓘ English 2025 2025 10.5851/kosfa.2024.e51 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ High PM2.5 episodes in Seoul, Korea, associated with Siberian High intensity ⓘ The Siberian High (SH) dominates the wintertime atmospheric circulation over East Asia which strongly modulates the concentration of particulate matter = 35 mu g m(-3)) in Seoul, Korea. Using a hierarchical clustering method, the synoptic patterns associated with 94 high-PM2.5 episodes in Seoul during the winters of 2008-2022 are classified into two groups based on the intensity of SH: 49 episodes with strong SH and 45 episodes with weak SH. Each SH pattern can induce high-PM2.5 episodes over distinct daily timescales through different dynamical and thermodynamical processes in the upper and lower troposphere. The strong SH is transformed into a migratory anticyclone over Korea, reducing wind speeds in the lower troposphere. These conditions suppress atmospheric ventilation and enhance dynamic stability, providing a favorable environment for rapid accumulation of PM2.5 near the surface within two days. During the weak SH events, the anticyclonic flow in the upper troposphere increases air temperatures in the mid-to-lower troposphere, resulting in increased low-tropospheric thermal stability. Air pollutants cannot disperse into the upper atmosphere and gradually accumulate to high PM2.5 levels over a period of four days. This study highlights that the development of atmospheric circulation in both strong and weak SH patterns plays an important role in the air quality degradation in Seoul through different temporal characteristics. These SH-driven atmospheric circulations provide valuable insights for improving forecast accuracy and enabling targeted emission control strategies based on the expected timing of pollution episodes. ⓘ Kim, Ka-Young; Ho, Chang-Hoi; Oh, Hye-Ryun; Choi, Woosuk; Kim, Jinwon; Cheung, Hung Ming ⓘ Seoul Natl Univ, Sch Earth & Environm Sci, Seoul, South Korea; Ewha Womans Univ, Dept Climate & Energy Syst Engn, Seoul, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea; Sejong Univ, Dept Artificial Intelligence & Data Sci, Seoul, South Korea ⓘ Cheung, Hung Ming/GLT-6870-2022; Ho, Chang-Hoi/H-8354-2015 ⓘ 57841940500; 59792039300; 35409958300; 55822495200; 57200530823; 56662737000 ⓘ hoch@ewha.ac.kr; ⓘ CLIMATE DYNAMICS ⓘ CLIM DYNAM ⓘ 0930-7575 1432-0894 63 5 SCIE METEOROLOGY & ATMOSPHERIC SCIENCES ⓘ 2024 3.7 32.9 N/A ⓘ 0 0 Air pollution; PM2.5; Siberian High; Atmospheric circulation ⓘ PARTICULATE MATTER; WINTER MONSOON; CLIMATE-CHANGE; AIR-POLLUTION; IMPACT; CHINA; TEMPERATURE; PATTERNS; HAZE; CLASSIFICATION ⓘ Air pollution; Atmospheric circulation; PM<sub>2.5</sub>; Siberian High ⓘ Seoul [Seoul (ADS)]; Seoul [South Korea]; South Korea; anticyclone; atmospheric circulation; atmospheric pollution; particulate matter; thermodynamics; troposphere ⓘ English 2025 2025-05 10.1007/s00382-025-07703-x ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Uses of Chemical Technologies for Meat Decontamination ⓘ Traditional meat preservation techniques such as smoking, drying, and salting have various shortcomings and limitations in effectively reducing microbial loads and maintaining meat quality. Consequently, chemical compounds have gained attention as promising alternatives for decontamination, offering the potential to extend shelf life and minimize physical, chemical, and sensory changes in meat. Chlorine-based compounds, trisodium phosphate, organic acids, bacteriocins, lactoferrin, and peracetic acid are technologies of recent industrial applications that inhibit spoilage and pathogenic microorganisms in meat. This review explores the critical aspects of decontamination and assesses the efficacy of different chemical compounds employed in meat preservation. These compounds exhibit strong microorganism inactivation capabilities, ensuring minimal alterations to the meat matrix and substantially reducing environmental impact. ⓘ Yim, Donggyun ⓘ Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea ⓘ ⓘ 56727813800 ⓘ dgyim@knu.ac.kr; ⓘ FOOD SCIENCE OF ANIMAL RESOURCES ⓘ FOOD SCI ANIM RESOUR ⓘ 2636-0772 2636-0780 45 1 SCIE FOOD SCIENCE & TECHNOLOGY ⓘ 2024 3.7 32.9 0 2025-05-07 ⓘ 0 0 decontamination; meat; chemical technology ⓘ ESCHERICHIA-COLI O157H7; ACIDIFIED SODIUM-CHLORITE; LACTIC-ACID BACTERIA; SALMONELLA-TYPHIMURIUM; ORGANIC-ACIDS; LISTERIA-MONOCYTOGENES; PEROXYACETIC ACID; ANTIMICROBIAL COMPOUNDS; PERACETIC-ACID; CITRIC-ACID ⓘ chemical technology; decontamination; meat ⓘ ⓘ English 2025 2025 10.5851/kosfa.2024.e102 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clinical effect on major trauma patients during simultaneous or overlapping presentations at an urban level I trauma center in Korea ⓘ Objective: Overcrowding in an emergency department (ED) or intensive care unit (ICU) of the trauma center (TC) is an important issue for timely acute health care of a critically injured patient. Accumulated scientific evidence has indicated the negative influence of overcrowding to the process and clinical outcome of trauma care. Method: The institutional trauma registry at an urban level I TC was retrospectively evaluated for 5 years (2018-2022). Major trauma was defined as an injury severity score (ISS) of >15. We determined simultaneous or overlapping presentations of major trauma (SOMT) in two or more patients with ISS of >15 who presented within a 4-h time window. When only two patients were included within a single time window, they were classified as SOMT-2, whereas when three or more patient clusters were identified in a single time window, they were classified as SOMT-3. The outcome measurement included process and clinical variables, such as trauma team activation (TTA) ratio, ED length of stay (LOS), time to blood product transfusion (TF), time to emergency surgery or intervention (ESI), ICU LOS, and mortality. Result: A total of 2,815 patients were included, of which 39.6% (N = 1,116) classified as SOMT. The SOMT group had lower TTA ratio than the non-SOMT group (69.4% vs. 73.4%, P = 0.022). The TTA ratio exhibited a decreasing trend in non-SOMT, SOMT-2, and SOMT-3 groups (P = 0.006). The time to TF was significantly delayed in the SOMT group (129 vs. 91 min, P < 0.001). Conclusion: SOMT regularly occurs and results in fewer trauma team activation and a delayed time to blood transfusion. The current intensive trauma care system should be strategically modified to improve critical trauma care and enhance disaster preparedness. ⓘ Park, Chang Won; Nho, Woo Young; Kim, Tae Kwon; Cho, Sung Hoon; Ahn, Jae Yun; Seo, Kang Suk ⓘ Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Trauma Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Emergency Med, Daegu, South Korea ⓘ ; Nho, Woo Young/JLN-0752-2023; Ahn, Jae Yun/N-2652-2017 ⓘ 57917945800; 57215831839; 57226863363; 57755400700; 56937505400; 57204305189 ⓘ wooyoung.nho@gmail.com; ⓘ INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED ⓘ INJURY ⓘ 0020-1383 1879-0267 56 1 SCIE CRITICAL CARE MEDICINE;EMERGENCY MEDICINE;ORTHOPEDICS;SURGERY ⓘ 2024 2 33.0 0 2025-05-07 ⓘ 0 0 Major trauma; overcrowding; trauma center; South Korea ⓘ EMERGENCY-DEPARTMENT; IMPACT; TRIAGE ⓘ Major trauma; overcrowding; South Korea; trauma center ⓘ Adult; Aged; Blood Transfusion; Emergency Service, Hospital; Female; Humans; Injury Severity Score; Intensive Care Units; Length of Stay; Male; Middle Aged; Multiple Trauma; Registries; Republic of Korea; Retrospective Studies; Time-to-Treatment; Trauma Centers; aged; Article; blood transfusion; clinical feature; clinical outcome; controlled study; crowding (area); emergency health service; emergency surgery; female; human; injury scale; Korea; length of stay; major clinical study; major injury; male; mortality rate; outcome assessment; retrospective study; adult; epidemiology; hospital emergency service; injury scale; intensive care unit; length of stay; middle aged; multiple trauma; register; South Korea; therapy; time to treatment ⓘ English 2025 2025-01 10.1016/j.injury.2024.111954 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Metabolomics Strategy Combining Countercurrent Separation and qNMR for the Comprehensive Chemical Evaluation of Polygoni Multiflori Radix Processing ⓘ IntroductionPolygoni Multiflori Radix (PMR) is commonly used in traditional medicine as both raw and processed forms. Raw PMR was prepared into processed PMR via processing procedure; however, there is a lack of standardized protocols ensuring the completeness of processing.ObjectiveThis aims to develop a strategy based on a metabolomics approach for the comprehensive chemical profiling and comparison of raw and processed PMR and establish a basis for PMR processing standardization.Materials and MethodsMethanol extracts of raw and processed PMR were fractionated by centrifugal partition chromatography (CPC) with an optimized two-phase solvent system based on the partition coefficient calculated from the shake-flask method to produce primary (1 degrees Ms)- and secondary metabolites (2 degrees Ms)-enriched fractions. These fractions were profiled by 1D and 2D and selective 1D NMR experiments, spectral fitting, and comparison with reference standards. The profiled compounds were quantified via quantitative 1H NMR (qHNMR) to show the chemical changes, which were correlated with changes in antioxidant effects on H2452 cells.ResultsA CPC method was developed to efficiently separate 1 degrees Ms- and 2 degrees Ms-enriched fractions. This method achieved high purity of the major stilbene in PMR in a single run. qHNMR effectively quantified four 2 degrees Ms and twenty-one 1 degrees Ms in both raw and processed PMR, including meso-butane-2,3-diol, which was first reported from processed PMR. Changes in chemical composition of PMR because of processing are highly correlated to the increase of antioxidant activity.ConclusionA convenient and cost-effective strategy for the comprehensive chemical profiling of raw and processed PMR was developed by combining countercurrent separation and qHNMR. This approach will contribute to the standardization of medicinal herbal materials. ⓘ Ngo, Trung Huy; Lee, Yoon-Jin; Choi, Hyukjae; Song, Kyung-Sik; Lee, Kyu Joon; Nam, Joo-Won ⓘ Yeungnam Univ, Coll Pharm, Gyongsan, Gyeongsangbuk D, South Korea; Soonchunhyang Univ, Coll Med, Dept Biochem, Cheonan Si, Chungcheongnam, South Korea; Yeungnam Univ, Res Inst Cell Culture, Gyongsan, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Soonchunhyang Univ, Coll Med, Dept Trop Med, Cheonan Si, Chungcheongnam, South Korea ⓘ ⓘ 57847967800; 57205464171; 7404339587; 13310139000; 59231984200; 8883246800 ⓘ kjl07@sch.ac.kr; jwnam@yu.ac.kr; ⓘ PHYTOCHEMICAL ANALYSIS ⓘ PHYTOCHEM ANALYSIS ⓘ 0958-0344 1099-1565 36 4 SCIE BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL;PLANT SCIENCES ⓘ 2024 2.6 33.2 0 2025-05-07 ⓘ 0 0 CPC; metabolomics; Polygoni Multiflori Radix; processing; qHNMR ⓘ STILBENE GLUCOSIDE; PURIFICATION; ROOTS; RATS ⓘ CPC; metabolomics; Polygoni Multiflori Radix; processing; qHNMR ⓘ Antioxidants; Countercurrent Distribution; Drugs, Chinese Herbal; Fallopia multiflora; Humans; Magnetic Resonance Spectroscopy; Metabolomics; Plant Extracts; Plant Roots; 2,3 butanediol; antioxidant; Fallopia multiflora extract; meso butane 2,3 diol; plant extract; unclassified drug; antioxidant; herbaceous agent; plant extract; Centrifugal partition chromatography; Chemical evaluation; Chemical profiling; Counter current; Metabolomics; Methanol extract; Polygoni multiflori radix; Processing procedures; Quantitative 1H NMR; Two-phase solvent system; antioxidant activity; Article; centrifugal partition chromatography; chemical fingerprinting; drug isolation; Fallopia multiflora; human; human cell; metabolomics; NCI-H2452 cell line; partition chromatography; partition coefficient; proton nuclear magnetic resonance; running; standardization; chemistry; counter current chromatography; nuclear magnetic resonance spectroscopy; plant root; procedures; Metabolites ⓘ English 2025 2025-06 10.1002/pca.3483 ⓘ 바로가기 바로가기 바로가기 바로가기
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