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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Therapeutic Potential of Santa Herba Extract in Obesity: Impact on Lipid Metabolism and Hormonal Balance | Many studies have reported that flavonoids can effectively suppress metabolic diseases related to obesity. Santa Herba extract (SHE), which is rich in flavonoids, has shown potential anti-obesity effects through clinical evaluations, but its anti-obesity mechanisms remain unclear. Therefore, an obese mouse model was established to further investigate its underlying mechanisms and biological effects. C57BL/6 mice were fed a high-fat diet (HFD) for 4 weeks to induce obesity and subsequently treated for 12 weeks with Orlistat (30 mg/kg) or SHE (50, 100, or 200 mg/kg). Body weight, food intake, fat mass (DEXA), serum biochemistry, histological changes, and gene/protein expression in liver and adipose tissue were analyzed. SHE200 reduced body weight by approximately 10%, fat mass by 15%, liver weight by nearly 40%, and epididymal adipocyte size by about 24% compared to the HFD group. Serum HDL was increased by approximately 1.2-fold, while LDL, ALT, and AST levels were reduced to 0.8-, 0.5-, and 0.6-fold of HFD levels, respectively. Leptin levels were also reduced to 0.6-fold of HFD levels, reflecting improvements in hormonal balance. In adipose tissue, FAS and ACC were reduced to approximately 0.6-fold of HFD levels, while key adipogenic transcription factors SREBP1c, CEBP alpha, and PPAR gamma were decreased to 0.5-, 0.6-, and 0.3-fold, respectively. PGC1 alpha and CPT1 alpha expression were modulated by SHE treatment, showing a 1.9-fold increase and 0.4-fold reduction, respectively. In liver tissue, similar reductions were observed, with FAS and ACC downregulated to 0.6- and 0.7-fold, and SREBP1c, CEBP alpha, and PPAR gamma suppressed to 0.4-, 0.5-, and 0.3-fold, respectively. Notably, PGC1 alpha expression increased by approximately 2.2-fold, while CPT1 alpha was reduced to about 0.5-fold. The findings underscore the potential of SHE as a natural, multi-targeted therapeutic agent for managing obesity and associated metabolic disorders. | Jo, Young-Hee; Hong, Eun-Mi; Kim, Sang-Back; Kim, Ju Gyeong; Lee, Sung-Jin; Son, Wansuk; Ma, Min-Jung; Kim, Sung Dae; Choi, Joo-Hee; Seo, Min-Soo | KolmarBNH Co Ltd, Food Sci R&D Ctr, Seoul, South Korea; FINE BS Co Ltd, Dept Nutraceut Ingredients Res, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu, South Korea | 59954459300; 59953335000; 59498800400; 59954096200; 59954647200; 59554427300; 59543242700; 55156746000; 55882556800; 35254332100 | cjh522@kmedihub.re.kr; msseo@knu.ac.kr; | FOOD SCIENCE & NUTRITION | FOOD SCI NUTR | 2048-7177 | 13 | 6 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 3.8 | 32.3 | 0 | 0 | body weight; caloric intake; flavonoids; homoeriodictyol; lipid accumulation; metabolic regulation | APOPTOSIS; STRESS; RATIO | body weight; caloric intake; flavonoids; homoeriodictyol; lipid accumulation; metabolic regulation | English | 2025 | 2025-06 | 10.1002/fsn3.70479 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Deciphering FOXM1 regulation: implications for stemness and metabolic adaptations in glioblastoma | The Forkhead box M1 (FOXM1) gene-mediated Wnt signaling pathway plays a significant role in the development and growth of glioblastoma multiforme (GBM), an exceptionally aggressive form of brain cancer. Our research explores the crucial involvement of the FOXM1 gene, a key transcription factor within the Wnt signaling pathway using bioinformatics techniques in both GBM and glioma stem cells (GSCs). Elevated FOXM1 gene expression is strongly associated with poor patient survival in GBM. Furthermore, FOXM1 gene expression is correlated with stemness-related factors, such as SOX2 and SOX9, which act as key drivers in the progression of cancer stem cells. Moreover, we specifically look into the direct associations of the FOXM1 gene with angiogenetic-related factors, metabolic genes, metastatic genes, pluripotency-related factors, immune cell infiltration, transcriptional networks, and functional category enrichment analysis, shedding light on the intricate molecular mechanisms involved in GBM initiation and progression. Additionally, our research identifies FOXM1-targeting miRNAs, revealing their potential as therapeutic candidates with implications for patient survival rates and DNA methylation patterns of the FOXM1 gene, uncovering insights into its epigenetic regulation. This knowledge contributes to a comprehensive understanding of the molecular landscape and potential avenues for developing more effective therapeutic approaches against GBM and GSCs. | Swati, Kumari; Arfin, Saniya; Agrawal, Kirti; Jha, Saurabh Kumar; Rajendran, Ramya Lakshmi; Prakash, Anand; Kumar, Dhruv; Gangadaran, Prakash; Ahn, Byeong-Cheol | Mahatma Gandhi Cent Univ, Sch Life Sci, Dept Biotechnol, Motihari 845401, Bihar, India; UPES, Sch Hlth Sci & Technol, Dehra Dun 248007, Uttrakhand, India; Univ Delhi, Kalindi Coll, Dept Zool, New Delhi 110008, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea; Univ Enclave Delhi, Ctr Himalayan Studies, Delhi 110007, India | Gangadaran, Prakash/AAV-3102-2021; Jha, Dr. Saurabh/ACC-9874-2022; Rajendran, Ramya/AAV-6338-2021 | 57226065885; 57223021904; 57918931500; 56425051500; 57195318729; 7202316614; 57211099780; 54393130400; 7202791511 | anandprakash@mgcub.ac.in; dhruvbhu@gmail.com; prakashg@knu.ac.kr; abc2000@knu.ac.kr; | MEDICAL ONCOLOGY | MED ONCOL | 1357-0560 | 1559-131X | 42 | 4 | SCIE | ONCOLOGY | 2024 | 3.5 | 32.4 | 0 | 2025-05-07 | 0 | 0 | FOXM1; Wnt signaling pathway; miRNA; Glioblastoma; Cancer stem cells | TRANSCRIPTION FACTOR; SOX FAMILY; CANCER; CELL; EXPRESSION; TARGET; IDENTIFICATION; PROLIFERATION; PROGRESSION; SURVIVAL | Cancer stem cells; FOXM1; Glioblastoma; miRNA; Wnt signaling pathway | Brain Neoplasms; DNA Methylation; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; MicroRNAs; Neoplastic Stem Cells; Wnt Signaling Pathway; forkhead box protein M1; kruppel like factor 4; microRNA; Myc protein; protein Mybl2; transcription factor; transcription factor Sox2; transcription factor Sox9; unclassified drug; forkhead box protein M1; FOXM1 protein, human; microRNA; angiogenesis; Article; astrocytoma; B lymphocyte; bioinformatics; cancer stem cell; cancer survival; CD4+ T lymphocyte; CD8+ T lymphocyte; cell infiltration; cell proliferation; cell stemness; differential gene expression; DNA methylation; down regulation; epigenetics; functional enrichment analysis; gene expression level; gene expression profiling; gene interaction; gene ontology; gene regulatory network; gene set enrichment analysis; glioblastoma; glioma stem cell; human; human tissue; immune evasion; immunocompetent cell; neutrophil; oligodendroglioma; overlapping gene; pluripotent stem cell; protein protein interaction; regulatory mechanism; survival rate; transcription regulation; tumor growth; tumor metabolism; tumor microenvironment; tumor-associated macrophage; upregulation; Wnt signaling; brain tumor; gene expression regulation; genetics; metabolism; pathology | English | 2025 | 2025-03-03 | 10.1007/s12032-025-02639-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dispersive eye-box extension in micro-OLED augmented reality glasses with a dual-holographic dispersion-compensating reflective combiner | We propose an eye-box extension method for augmented reality (AR) glasses utilizing a dual-holographic optical element (dual-HOE) and a micro-OLED (mu OLED) light source with a broadband spectrum. This scheme leverages the strong chromatic dispersion of HOE to significantly extend the eye-box without compromising AR quality. The proportional relationship between mu OLED spectral bandwidth and eye-box size is analyzed theoretically, indicating that a broader spectrum mu OLED provides a wider eye-box. Experimental results using a prototype demonstrate eye-box expansion up to 8 mm for mu OLED with a 60 nm spectral bandwidth. (c) 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved. | Kim, Sangyoon; Jeon, Hosung; Jeon, Youngjin; Kim, Youngsub; Hahn, Joonku; Kim, Hwi | Korea Univ, Coll Sci & Technol, Dept Elect & Informat Engn, Sejong Campus, 2511 Sejong Ro, Sejong 30019, South Korea; Kyungpook Natl Univ, Sch Elect & Informat Engn, 80 Daehak Ro, Daegu 41566, South Korea | 57216735264; 56663784700; 57193385596; 59344013500; 10142501600; 8933596300 | hwikim@korea.ac.kr; | OPTICS LETTERS | OPT LETT | 0146-9592 | 1539-4794 | 50 | 7 | SCIE | OPTICS | 2024 | 3.3 | 32.4 | 0 | 2025-05-07 | 1 | 1 | Holographic optical elements; Holography; Laser beams; Optical glass; Organic light emitting diodes (OLED); Box sizes; Broad spectrum; Broadband spectra; Dispersion compensating; Extension methods; Micro-OLEDs; Optical-; Proportional relationships; Spectral bandwidth; article; augmented reality; bandwidth; dispersion; drug therapy; nonhuman; smart glasses; Chromatic dispersion | English | 2025 | 2025-04-01 | 10.1364/ol.555710 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Eye-box extension in micro-OLED augmented reality near-eye display with a holographic multi-path optical element combiner | We present a holographic multi-path (HMP) approach to extend the eye-box of the off-axis reflective holographic optical element (HOE) combiners for micro-OLED augmented reality (AR) near-eye displays (NEDs). The compact form factor design requirement highly constrains the eye-box and the field of view (FOV) in the off-axis reflection HOE AR combiners. In this Letter, we show that multiplexing multiple independent optical paths into a HOE effectively extends the eye-box. In the proposed multi-path multiplexing approach, separate partial images of a micro-OLED are routed along the multiplexed beam paths and combined to generate a complete AR image. The experiment verifies that the multipath multiplexing achieves a twofold increase in the eye-box compared to previous results, enhancing the user experi(AI) training, and similar technologies, are reserved. | Kim, Sangyoon; Jeon, Hosung; Jeon, Youngjin; Jeong, Sehyeon; Kim, Young Sub; Hahn, Joonku; Kim, Hwi | Korea Univ, Coll Sci & Technol, Dept Elect & Informat Engn, Sejong Campus,2511 Sejong ro, Sejong 30019, South Korea; Elect & Telecommun Res Inst, 218 Gajeong ro, Daejeon 305700, South Korea; Kyungpook Natl Univ, Sch Elect & Informat Engn, 80 Daehak ro, Daegu 41566, South Korea | 57216735264; 56663784700; 57193385596; 59496409800; 59344013500; 10142501600; 8933596300 | hwikim@korea.ac.kr; | OPTICS LETTERS | OPT LETT | 0146-9592 | 1539-4794 | 50 | 12 | SCIE | OPTICS | 2024 | 3.3 | 32.4 | N/A | 0 | 0 | Holographic displays; Beam path; Field of views; Form factors; Micro-OLEDs; Multi-path approaches; Multipath; Off-axis; Optical path; Optical-; Result enhancing; article; augmented reality; controlled study; human; optics; Holographic optical elements | English | 2025 | 2025-06-15 | 10.1364/ol.566486 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Review | Mesenchymal stem cell-derived exosomes: A paradigm shift in clinical therapeutics | Mesenchymal stromal/stem cell (MSC)-derived exosomes are nanoscale extracellular vesicles that have emerged as promising candidates for therapeutic and diagnostic applications because of their unique bioactive cargo, including proteins, lipids, and nucleic acids. These vesicles mitigate concerns of immunogenicity and tumorigenicity associated with MSC-based therapies and offer enhanced stability, higher scalability, and ease of modification. However, the use of MSC-derived exosomes in clinical practice is associated with challenges, including difficulties in isolation, characterization, and standardization. This review explores the biogenesis and structural properties of MSC-derived exosomes and discusses the molecular mechanisms underlying their therapeutic effects. It also discusses ongoing clinical trials on their applications in cancer, cardiovascular, neurological, and regenerative medicine. Preclinical and clinical data have demonstrated the potential of MSC-derived exosomes in enhancing tissue repair, reducing inflammation, and modulating immune responses. Despite these advancements, gaps in scalable production methods, regulatory guidelines, and therapeutic consistency must be addressed. Future innovations in bioengineering, manufacturing, and regulatory frameworks are essential to realize the full potential of MSC-derived exosomes in mainstream medicine. | Chattopadhyay, Sayantani; Rajendran, Ramya Lakshmi; Chatterjee, Gargii; Reyaz, Danyal; Prakash, Kruthika; Hong, Chae Moon; Ahn, Byeong-Cheol; ArulJothi, Kandasamy Nagarajan; Gangadaran, Prakash | SRM Inst Sci & Technol, Fac Engn & Technol, Dept Genet Engn, Chengalpattu 603203, Tamilnadu, India; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea | Gangadaran, Prakash/AAV-3102-2021; ArulJothi, KN/AFU-0629-2022; Rajendran, Ramya/AAV-6338-2021 | 59699971800; 57195318729; 59909861400; 59527540100; 59733317200; 37050876700; 59527540200; 56705564100; 54393130400 | abc2000@knu.ac.kr; aruljotn@srmist.edu.in; prakashg@knu.ac.kr; | EXPERIMENTAL CELL RESEARCH | EXP CELL RES | 0014-4827 | 1090-2422 | 450 | 1 | SCIE | CELL BIOLOGY;ONCOLOGY | 2024 | 3.5 | 32.4 | 0 | 2025-06-11 | 0 | 0 | mesenchymal stromal/stem cells; Exosomes; Extracellular vesicles; Therapeutic applications; Immunomodulation | EXTRACELLULAR VESICLES; MEDIATED ENDOCYTOSIS; TARGETED THERAPY; DELIVERY; MSC; STRATEGIES; MECHANISM | Exosomes; Extracellular vesicles; Immunomodulation; mesenchymal stromal/stem cells; Therapeutic applications | Animals; Exosomes; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neoplasms; Regenerative Medicine; biogenesis; carcinogen testing; carcinogenicity; clinical practice; clinical practice guideline; exosome; human; immune response; immunogenicity; immunomodulation; immunotherapy; inflammation; mesenchymal stem cell; mesenchyme; neoplastic cell transformation; nonhuman; pharmaceutics; practice guideline; regenerative medicine; review; standardization; stem cell; stroma; therapy; tissue repair; animal; cytology; mesenchymal stem cell transplantation; metabolism; neoplasm; procedures; transplantation | English | 2025 | 2025-07-01 | 10.1016/j.yexcr.2025.114616 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prevalence and characteristics of impacted teeth in Korean orthodontic patients at ten university dental hospitals | Objective: This study aimed to investigate the prevalence and characteristics of impacted teeth (ITs) in orthodontic patients at university dental hospitals in Korea. Methods: This study included 14,774 patients who visited the Department of Orthodontics at 10 university dental hospitals in Korea between 2020 and 2022 and underwent orthodontic diagnosis. The prevalence and characteristics of ITs were investigated using orthodontic diagnostic records, radiographs, and diagnostic casts. Results: The prevalence of ITs, excluding third molar impaction, in Korean orthodontic patients was 13.6% (n = 2,014). The prevalence of ITs in pediatric orthodontic patients was 24.5% (n = 1,614). Of these patients, 68.2% had one IT, 27.5% had two ITs, 24.3% had bilateral IT, and 75.7% had unilateral IT. The most frequent IT was the maxillary canine (50.1%), followed by the mandibular second molar (11.7%), and maxillary second premolar (9.6%). An abnormal eruption path (46.5%) was the most frequent etiology. Orthodontic traction after surgical exposure (70.6%) was the most frequent treatment option. Among the patients with ITs, 29.8% had other dental anomalies, such as tooth agenesis (8.7%), microdontia (8.0%), and supernumerary teeth (5.1%). Furthermore, 50.8% had complications such as cystic lesions (18.3%), transposition (17.7%), and root resorption (14.8%). Among the patients with maxillary canine impaction, 62.2% had labial maxillary canine impaction and 21.1% had palatal maxillary canine impaction. Conclusions: The prevalence of ITs in Korean orthodontic patients at university dental hospitals was high, particularly in pediatric orthodontic patients. | Choi, Youn-Kyung; Kim, Sung-Hun; Kim, Yong-Il; Kim, Seong-Sik; Park, Soo-Byung; Choi, Dong-Soon; Kim, Ho-Jin; Kim, Kyung-A; Lee, Mo-Hyeon; Choi, Sung-Hwan; Choi, Sung-Kwon; Lee, Kyungmin Clara; Jeon, Young-Mi; Oh, Sewoong; Jeong, Seorin | Pusan Natl Univ, Dent Res Inst, Sch Dent, Dept Orthodont, 20 Geumo Ro, Yangsan 50612, South Korea; Pusan Natl Univ, Dent & Life Sci Inst, Sch Dent, 20 Geumo Ro, Yangsan 50612, South Korea; Gangneung Wonju Natl Univ, Coll Dent, Dept Orthodont, Kangnung, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu, South Korea; Kyung Hee Univ, Sch Dent, Dept Orthodont, Seoul, South Korea; Dankook Univ, Coll Dent, Dept Orthodont, Cheonan, South Korea; Yonsei Univ, Coll Dent, Inst Craniofacial Deform, Dept Orthodont, Seoul, South Korea; Wonkwang Univ, Sch Dent, Dept Orthodont, Iksan, South Korea; Chonnam Natl Univ, Sch Dent, Dept Orthodont, Gwangju, South Korea; Jeonbuk Natl Univ, Sch Dent, Dept Orthodont, Jeonju, South Korea; Chosun Univ, Coll Dent, Dept Orthodont, Gwangju, South Korea | Choi, Sung-Hwan/AAE-2350-2021; choi, younkyung/KBB-7463-2024; Choi, Sung-Hwan/T-6925-2019 | 56173154800; 57193128482; 57218595743; 27167566200; 35750236100; 56175333200; 57200084686; 56074113600; 58286668300; 57193721264; 57212023246; 57219671384; 35368384900; 57192663224; 57193110501 | siesta@pusan.ac.kr; | KOREAN JOURNAL OF ORTHODONTICS | KOREAN J ORTHOD | 2234-7518 | 2005-372X | 55 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2024 | 2.3 | 32.4 | 0 | 2025-06-11 | 0 | 0 | Prevalence; Impacted tooth; Orthodontic patient; University dental hospital | ROOT APEX; MAXILLARY; ANOMALIES; CANINE; JAW | Impacted tooth; Orthodontic patient; Prevalence; University dental hospital | English | 2025 | 2025-05 | 10.4041/kjod24.213 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A novel clinical investigation using deep learning and human-in-the-loop approach in orbital volume measurement | Orbital volume assessment is crucial for surgical planning. Traditional methods lack efficiency and accuracy. Recent studies explore AI-driven techniques, but research on their clinical effectiveness is limited. This study included 349 patients aged 19 years and above, who underwent three-dimensional facial computed tomography (3DCT) without orbital trauma or congenital anomalies. To construct an AI training dataset, manual segmentation was performed on 178 patients' 3DCT using 3D Slicer. The remaining data of 171 patients underwent human-in-the-loop method, resulting in a dataset of 349 annotated samples. Comparative analysis of Dice coefficients and execution speeds was performed between manual and semi-automated segmentations. Comparing AI-assisted semi-automated segmentation with manual segmentation, all six annotators demonstrated lower average inference times without a significant difference in Dice coefficients (90.31% vs. 88.72%). For 178 patients' 3DCT, a high average Dice coefficient of 89.9% was observed, and a 38.42-ms inference time was recorded. For the full dataset, the AI model achieved a high average Dice coefficient of 94.1% and a fast average inference time of 32.55 ms per axial slice. This study demonstrates the potential of AI for maintaining high accuracy and time-efficiency in orbital region segmentation, with wide clinical applications. | Chang, Yong June; Cho, Jungrae; Shon, Byungeun; Choi, Kang Young; Jeong, Sungmoon; Ryu, Jeong Yeop | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, 680 Gukchaebosanro, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022 | 57949685900; 57205507149; 58635954000; 59816612700; 23100090400; 56366349400 | jyj6449@naver.com; zzemb6@gmail.com; jeongsm00@gmail.com; prsryu@knu.ac.kr; | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | J CRANIO MAXILL SURG | 1010-5182 | 1878-4119 | 53 | 5 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Orbital volume; Artificial intelligence; Human-in-the-Loop | COMPUTED-TOMOGRAPHY; LATE ENOPHTHALMOS; SEGMENTATION; PREDICTION; FRACTURES; SOFTWARE | Artificial intelligence; Human-in-the-Loop; Orbital volume | Adult; Aged; Deep Learning; Female; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Orbit; Organ Size; Tomography, X-Ray Computed; Young Adult; adult; Article; artificial intelligence; clinical effectiveness; comparative study; computer assisted tomography; deep learning; digital imaging and communications in medicine; female; frontozygomatic suture; human; human tissue; image segmentation; lacrimal sac; major clinical study; male; orbit; orbit injury; plastic surgeon; retrospective study; aged; diagnostic imaging; middle aged; orbit; organ size; procedures; three-dimensional imaging; x-ray computed tomography; young adult | English | 2025 | 2025-05 | 10.1016/j.jcms.2025.01.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Acoustic analysis of nasalance and formants in VPI patients: Implications for clinical practice and mobile application development | Velopharyngeal insufficiency (VPI) often results in speech abnormalities, making accurate evaluation essential for understanding its relationship with structural anomalies. This retrospective study, spanning January 2019 to December 2022, investigates the role of formant analysis in speech evaluation and treatment. We analyzed speech data from 100 adults, 55 children, and 10 pediatric patients with VPI using Nasometer and PRAAT software, focusing on the sounds Pa, Pi, Pu, Pe, and Po. Nasalance scores and formants 1–4 were measured both pre- and post-VPI surgery and correlated with age, gender, and surgical outcomes. In both normal adults and children, the distributions of formants 1 and 2 for the vowels |a|, |e|, |i|, |o|, and |u| showed variations by age. Gender differences were significant in adults for the vowels |a|, |o|, and |u|, but not in children. VPI surgery significantly improved nasalance scores, and notable changes in formants 1 and 2 were observed post-surgery in VPI patients for the vowels |a|, |e|, and |i|. This study emphasizes the importance of formant analysis in speech therapy and introduces the potential for mobile app-based self-assessment. This approach reduces the reliance on specialized tools, such as nasometers, and provides a more accessible method for the speech management. © 2025 European Association for Cranio-Maxillo-Facial Surgery | Kang, Myeong Jae; Ryu, Jeong Yeop; Lee, Joon Seok; Yang, Jung Dug; Chung, Ho Yun; Choi, Kang Young | Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea | 57445997600; 56366349400; 59349262100; 55171704700; 7404007181; 57203745682 | kychoi@knu.ac.kr; | Journal of Cranio-Maxillofacial Surgery | J CRANIO MAXILL SURG | 1010-5182 | 1878-4119 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | Acoustic analysis; Formants; Mobile app; VPI | English | Article in press | 2025 | 10.1016/j.jcms.2025.03.018 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Diagnostic Accuracy of a Deep Learning Algorithm for Detecting Unruptured Intracranial Aneurysms in Magnetic Resonance Angiography: A Multicenter Pivotal Trial | BACKGROUND: Intracranial aneurysm rupture is associated with high mortality and disability rates. Early detection is crucial, but increasing diagnostic workloads place significant strain on radiologists. We evaluated the efficacy of a deep learning algorithm in detecting unruptured intracranial aneurysms (UIAs) using time-of-flight (TOF) magnetic resonance angiography (MRA). METHODS: Data from 675 participants (189 aneurysmpositive [221 UIAs] and 486 aneurysm-negative) were collected from 2 hospitals (2019-2023). Positive cases were confirmed by digital subtraction angiography, and images were annotated by vascular experts. The 3D U-Netbased model was trained on 988 nonoverlapped TOF MRA datasets and evaluated by patient- and lesion-level sensitivity, specificity, and false-positive rates. RESULTS: The mean age was 59.6 years (standard deviation 11.3), and 52.0% were female. The model achieved patient-level sensitivity of 95.2% and specificity of 80.5%, with lesion-level sensitivity of 89.6% and a false-positive rate of 0.19 per patient. Sensitivity by aneurysm size was 72.3% for lesions 5 mm. Performance was consistent across institutions, with an area under the receiver operating characteristic curve of 0.949. CONCLUSIONS: The software demonstrated high sensi-tivity and low false-positive rates for UIA detection in TOF MRA, suggesting its utility in reducing diagnostic errors and alleviating radiologist workload. Expert review re-mains essential, particularly for small or complex aneurysms. | Ryu, Wi-Sun; Jeong, Sungmoon; Park, Jaechan; Park, Dougho; Kim, Heeyoung; Lee, Myungjae; Kim, Dongmin; Kim, Myungsoo; Kim, Byoung-joon; Lee, Hui Joong | JLK Inc, Artificial Intelligence Res Ctr, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Pohang Stroke & Spine Hosp, Med Res Inst, Pohang, South Korea; Pohang Univ Sci & Technol, Sch Convergence Sci & Technol, Pohang, South Korea; Kwangwoon Univ, Inst Informat Technol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea | ; Park, Dougho/HHS-3971-2022 | 7004968337; 23100090400; 44661451000; 57221124200; 59717903200; 59152710200; 58145618000; 57210943611; 57201448189; 23485776600 | jparkneurosurgery@gmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 197 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Artificial intelligence; Deep learning; Intracranial aneurysm | MR-ANGIOGRAPHY | Artificial intelligence; Deep learning; Intracranial aneurysm | Adult; Aged; Algorithms; Angiography, Digital Subtraction; Deep Learning; Female; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Sensitivity and Specificity; adult; aneurysm diameter; aneurysm size; Article; artificial intelligence; clinical effectiveness; controlled study; convolutional neural network; deep learning; diagnostic accuracy; diagnostic test accuracy study; digital subtraction angiography; false positive result; female; human; intracranial aneurysm; learning algorithm; machine learning algorithm; magnetic resonance angiography; major clinical study; male; middle aged; multicenter study; neuroradiologist; predictive value; receiver operating characteristic; residual neural network; sensitivity and specificity; university hospital; unruptured intracranial aneurysm; validation study; aged; algorithm; clinical trial; diagnostic imaging; intracranial aneurysm; procedures | English | 2025 | 2025-05 | 10.1016/j.wneu.2025.123882 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of a context-aware chatbot using retrieval-augmented generation for answering clinical questions on medication-related osteonecrosis of the jaw | The potential of large language models (LLMs) in medical applications is significant, and Retrieval-augmented generation (RAG) can address the weaknesses of these models in terms of data transparency and scientific accuracy by incorporating current scientific knowledge into responses. In this study, RAG and GPT-4 by OpenAI were applied to develop GuideGPT, a context aware chatbot integrated with a knowledge database from 449 scientific publications designed to provide answers on the prevention, diagnosis, and treatment of medication- related osteonecrosis of the jaw (MRONJ). A comparison was made with a generic LLM ("PureGPT") across 30 MRONJ-related questions. Ten international experts in MRONJ evaluated the responses based on content, language, scientific explanation, and agreement using 5-point Likert scales. Statistical analysis using the Mann-Whitney U test showed significantly better ratings for GuideGPT than PureGPT regarding content (p = 0.006), scientific explanation (p = 0.032), and agreement (p = 0.008), though not for language (p = 0.407). Thus, this study demonstrates RAG to be a promising tool to improve response quality and reliability of LLMs by incorporating domain-specific knowledge. This approach addresses the limitations of generic chatbots and can provide traceable and up-to-date responses essential for clinical practice. | Steybe, David; Poxleitner, Philipp; Aljohani, Suad; Herlofson, Bente Brokstad; Nicolatou-Galitis, Ourania; Patel, Vinod; Fedele, Stefano; Kwon, Tae-Geon; Fusco, Vittorio; Pichardo, Sarina E. C.; Obermeier, Katharina Theresa; Otto, Sven; Rau, Alexander; Russe, Maximilian Frederik | Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Oral & Maxillofacial Surg & Facial Plast Surg, Munich, Germany; King Abdulaziz Univ, Fac Dent, Dept Oral Diagnost Sci, Jeddah, Saudi Arabia; Oslo Univ Hosp, Fac Dent, Dept Oral Surg & Oral Med, Oslo, Norway; Oslo Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Div Head Neck & Reconstruct Surg, Oslo, Norway; Ippokrateio Gen Hosp, CureCanc Mycanc Gr, Athens, Greece; Guys & St Thomas Hosp, Dept Haematol, London, England; UCL, Eastman Dent Inst, London, England; UCL, NIHR UCLH Biomed Res Ctr, London, England; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea; SS Antonio & Biagio & CArrigo Hosp, Oncol Unit, Dept Med, Alessandria, Italy; SS Antonio & Biagio & CArrigo Hosp, DAIRI Dept Integrat Res & Innovat, Translat Med Unit, Alessandria, Italy; Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands; Univ Freiburg, Univ Med Ctr Freiburg, Dept Neuroradiol, Med Ctr, Freiburg, Germany; Univ Freiburg, Univ Med Ctr Freiburg, Fac Med, Dept Diagnost & Intervent Radiol, Freiburg, Germany | Pichardo, Sarina/JQV-4729-2023; Rau, Alexander/AAK-3948-2021; Aljohani, suad/AAX-4312-2021 | 57203914010; 55802324900; 37021205100; 6602630009; 6701317806; 7402495206; 7004087651; 35205433300; 7102894939; 55524198400; 56316708200; 35337478900; 57205328239; 16314201300 | david.steybe@med.uni-muenchen.de; | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | J CRANIO MAXILL SURG | 1010-5182 | 1878-4119 | 53 | 4 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;SURGERY | 2024 | 2.1 | 32.5 | 6.12 | 2025-05-07 | 2 | 2 | Large language models; GPT-4; Generative pre-trained transformer; Retrieval-augmented generation; Clinical practice guidelines; Medication-related osteonecrosis of the jaw | SURGEONS POSITION PAPER; AMERICAN ASSOCIATION | Clinical practice guidelines; Generative pre-trained transformer; GPT-4; Large language models; Medication-related osteonecrosis of the jaw; Retrieval-augmented generation | Bisphosphonate-Associated Osteonecrosis of the Jaw; Humans; Information Storage and Retrieval; accuracy; Article; artificial intelligence chatbot; ChatGPT; clinical practice guideline; controlled study; diagnosis; information processing; information retrieval; knowledge base; large language model; Likert scale; medical information; medication related osteonecrosis of the jaw; Medline; prevention; publication; quality control; reliability; retrieval augmented generation; statistical analysis; treatment indication; bisphosphonate related osteonecrosis of the jaw; human; procedures; surgery | English | 2025 | 2025-04 | 10.1016/j.jcms.2024.12.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Functionalized MIL-125(Ti)-based high-performance triboelectric nanogenerators for hygiene monitoring | Metal-organic frameworks (MOFs) have emerged as promising materials for energy harvesting through triboelectric nanogenerators (TENGs). Strategic incorporation of functional groups within the MOFs offers a method for tailoring the surface and functional properties of composite materials, thus leading to enhancement in the performance of TENGs. This study investigates the relationship between functional groups and TENG performance using MIL-125(Ti), specifically incorporating electron-donating (NH2) and electron-withdrawing (NO2) groups. MIL-125(Ti)-NH2@silicone composite film, along with aluminum, produces a maximum voltage and current of 512 V and 130 μA, and a power density of 6.75 W m−2, which is twice the power density of the pure silicone-based TENG. The enhancement of TENG output is attributed to the functionalization of MIL-125, which results in the change of dielectric constant, work function and tuning of the band gap of the composite materials. Furthermore, a novel TENG-based door sensor was demonstrated for the application of a smart alert hygiene system. This sensor efficiently tracks the number of washroom usages by detecting door movements. The real-time data generated by the system notifies the cleaning staff, ensuring the maintenance of a cleaner and more hygienic washroom environment. The study highlights the potential of functionalized MIL-125(Ti)-based TENGs for efficient energy harvesting and sustainable hygiene monitoring. © 2025 RSC. | Babu, Anjaly; Madathil, Navaneeth; Rajaboina, Rakesh Kumar; Borkar, Hitesh; Devarayapalli, Kamakshaiah Charyulu; Mishra, Yogendra Kumar; Hajra, Sugato; Kim, Hoe Joon; Khanapuram, Uday Kumar; Lee, Dae Sung | Department of Physics, Energy Materials and Devices (EMD) Lab, National Institute of Technology, Warangal, 506004, India; Department of Physics, Energy Materials and Devices (EMD) Lab, National Institute of Technology, Warangal, 506004, India; Department of Physics, Energy Materials and Devices (EMD) Lab, National Institute of Technology, Warangal, 506004, India; Department of Physics, Energy Materials and Devices (EMD) Lab, National Institute of Technology, Warangal, 506004, India; Department of Environmental Engineering, Kyungpook National University, Buk-gu, Daegu, 41566, South Korea; Smart Materials, NanoSYD, Mads Clausen Institute, University of Southern Denmark, Alsion 2, Sønderborg, 6400, Denmark; Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, South Korea; Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, 42988, South Korea; Department of Physics, Energy Materials and Devices (EMD) Lab, National Institute of Technology, Warangal, 506004, India; Department of Environmental Engineering, Kyungpook National University, Buk-gu, Daegu, 41566, South Korea | 57459650900; 58551320700; 59242864300; 56110189400; 15069351300; 57212300501; 57202436777; 55502950800; 57785147700; 55568524907 | kanapuram.udaykumar@nitw.ac.in; daesung@knu.ac.kr; | Materials Advances | MATER ADV | N/A | 2633-5409 | ESCI | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.7 | 32.5 | N/A | 0 | English | Article in press | 2025 | 10.1039/d5ma00283d | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | ○ | Review | Lighting the Path to Practical Applications of Single-Atom Catalysts in Photocatalysis: The Role of Platinum Group Single Atoms in Enhancing Catalytic Activity | Single-atom catalysts (SACs) show promise because of their efficient use of precious metals, unique coordination and electronic structures, and excellent tunability. Photocatalysis can harvest solar energy to drive energetically unfavorable reactions under mild conditions, offering a sustainable alternative to energy-intensive reactions. However, the efficiency of solar photocatalysis is limited by poor solar spectrum utilization and rapid charge recombination. Integrating single atoms into semiconductor photocatalysts is a promising route to address these limitations. Mechanistic understanding of single-atom photocatalysis is crucial for developing efficient catalysts as they guide effective material design. This work provides an overview of the current knowledge on platinum group SACs applied to photocatalytic applications with a focus on the role of single atoms in photocatalytic reactions. The review begins with a summary of the unique advantages of platinum group metal SACs as well as their common structures. A concise summary of synthesis methods is then provided, followed by a comprehensive review of characterization methods for SAC structure, photoelectronic properties, and mechanisms of action. Next, the role of single atoms in improving general photocatalytic processes as well as specific reactions are discussed. Finally, future outlooks for SAC development are included to guide further advancements in the field. | Chen, Zi Qi; Ngan, Aldrich; Chan, Christopher; Lee, Jaeha; Sanjaya, David Dwi; Gu, Frank | Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada; Kyungpook Natl Univ, Coll Engn, Dept Appl Chem, Daegu, South Korea; Univ Toronto, Dept Chem, Toronto, ON, Canada; Univ Toronto, Inst Water Innovat, Toronto, ON, Canada; Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada | ; Gu, Frank/G-8381-2011; Gu, Frank/HNS-2665-2023 | 58528355800; 57219110928; 58856738400; 59510667600; 59665783700; 35922875900 | f.gu@utoronto.ca; | SOLAR RRL | SOL RRL | 2367-198X | 9 | 6 | SCIE | ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.7 | 32.5 | 0 | 2025-05-07 | 0 | 0 | material characterization; mechanism; photocatalysis; platinum group metals; single atom catalysts | RAY-ABSORPTION-SPECTROSCOPY; METAL-SUPPORT INTERACTION; COVALENT ORGANIC FRAMEWORKS; GRAPHITIC CARBON NITRIDE; HYDROGEN EVOLUTION; CHARGE-TRANSFER; NITROGEN-FIXATION; CO2 REDUCTION; RECENT PROGRESS; MECHANISTIC INSIGHT | material characterization; mechanism; photocatalysis; platinum group metals; single atom catalysts | Bioremediation; Carrier concentration; Coordination reactions; Crystal atomic structure; Photocatalysts; Photocatalytic activity; Coordination structures; Electronic.structure; Energy; Materials characterization; Platinum group metals; Platinum-group; Single atom catalyst; Single-atoms; Tunabilities; ]+ catalyst; Platinum | English | 2025 | 2025-03 | 10.1002/solr.202400804 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reduction-First Technique of Unilateral Biportal Endoscopy Lumbar Interbody Fusion for Spondylolisthesis | The reduction-first technique in unilateral biportal endoscopy (UBE) lumbar interbody fusion is a novel approach designed to overcome the limitations of conventional UBE fusion for spondylolisthesis. UBE fusion has gained popularity as a minimally invasive procedure, yet its ability to achieve satisfactory vertebral reduction remains limited, particularly in patients with higher-grade spondylolisthesis. This paper introduces a modified technique in which a right-sided pedicle screw is placed prior to cage insertion, facilitating early reduction of spondylolisthesis and improving interbody cage positioning. By addressing both the ipsilateral and contralateral facet joints under endoscopic visualization, the reduction-first technique enhances reduction and disc height restoration while maintaining minimal invasiveness. We present 2 clinical cases in which this technique was successfully applied, resulting in significant improvements in lumbar lordosis, sagittal vertical alignment, and clinical outcomes. Immediate postoperative radiographs and followup imaging demonstrated improved reduction and solid fusion at 6 months postoperatively. Although long-term outcomes have not yet been determined, this technique shows promise in expanding the indications for UBE fusion, even in patients with higher-grade spondylolisthesis. | Jung, Jinwoo; Park, Man-Kyu; Park, Yong Jin; Cho, Dae-Chul; Ko, Young San | Hu Hosp, Dept Neurosurg, Busan, South Korea; Suncheon Hana Hosp, Dept Orthopaed Surg, Sunchon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea | 57222116456; 55661966300; 59757725700; 55859543400; 57216731206 | samkyu1@hotmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 198 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-06-11 | 0 | 0 | Lumbar interbody fusion; Unilateral biportal endoscopy; Minimally invasive spine surgery | TLIF | Lumbar interbody fusion; Minimally invasive spine surgery; Unilateral biportal endoscopy | adult; aged; Article; case report; clinical article; clinical outcome; endoscopy; female; fluoroscopy; follow up; human; intervertebral disk; leg pain; low back pain; lumbar interbody fusion; lumbar lordosis angle; lumbar spinal stenosis; male; middle aged; minimally invasive spine surgery; Oswestry Disability Index; pelvic incidence; reduction first technique; spine radiography; spondylolisthesis; surgical technique; unilateral biportal endoscopy; vertebral height; visual analog scale; zygapophyseal joint | English | 2025 | 2025-06 | 10.1016/j.wneu.2025.124005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unilateral Biportal Endoscopic Discectomy via the Contralateral Sublaminar Approach for Lumbar Disc Herniation with Very High-Grade Migration: A Technical Note and Case Series | BACKGROUND: Lumbar disc herniation (LDH) with very high-grade migration is difficult to manage surgically because of its anatomic complexity and the risk of incomplete decompression. The unilateral biportal endoscopic (UBE) contralateral sublaminar approach is a minimally invasive technique that may be an alternative option for managing these cases. METHODS: In this multicenter retrospective study, we analyzed the clinical data of 15 patients with lumbar disc herniation with very high-grade upward or downward migration of ruptured disc fragments removed via the UBE contralateral sublaminar approach between June 2022 and June 2024. Clinical outcomes were assessed using the visual analog scale for back and leg pain, Oswestry Disability Index, and modified MacNab criteria. Radiologic outcomes were evaluated on postoperative magnetic resonance images and serial plain radiographs. RESULTS: The mean operation time was 45.3 minutes, and the average length of hospital stay was 4.1 days. The visual analog scale scores for back and leg pain improved significantly, and the Oswestry Disability Index was notably lower at the final follow-up. Postoperative magnetic resonance imaging confirmed the complete removal of migrated disc fragments in all patients, with no segmental instability observed during the follow-up. The technique allows for effective decompression with minimal bone removal, thereby preserving adjacent structures. CONCLUSIONS: This study showed the feasibility and potential benefits of the UBE contralateral sublaminar approach for lumbar disc herniation with very high-grade migration of ruptured disc fragments. Although initial outcomes are promising, further comparative studies with more patients are needed to validate its efficacy and safety. | Park, Yong Jin; Park, Man Kyu; Son, Sang Kyu; Ko, Young San | Suncheon Hana Hosp, Dept Orthopaed Surg, Sunchon, South Korea; Hu Hosp, Dept Neurosurg, Washington, DC USA; Good Moonhwa Hosp, Dept Neurosurg, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea | 59757725700; 55661966300; 57429658600; 57767618800 | samkyu1@hotmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 197 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Discectomy; Endoscopic; High-grade migration; Lumbar disc herniation | Discectomy; Endoscopic; High-grade migration; Lumbar disc herniation | Adult; Aged; Diskectomy; Endoscopy; Female; Humans; Intervertebral Disc Degeneration; Intervertebral Disc Displacement; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Treatment Outcome; adult; aged; Article; backache; clinical article; clinical outcome; decompression surgery; discectomy; endoscopic surgery; female; follow up; hospitalization; human; leg pain; length of stay; lumbar disk hernia; male; nuclear magnetic resonance imaging; operation duration; Oswestry Disability Index; retrospective study; spine radiography; visual analog scale; clinical trial; diagnostic imaging; endoscopy; intervertebral disk degeneration; intervertebral disk hernia; lumbar vertebra; middle aged; multicenter study; procedures; surgery; treatment outcome | English | 2025 | 2025-05 | 10.1016/j.wneu.2025.123939 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Prevalence and molecular characterization of intestinal parasites in shelter dogs from South Korea | The prevalence and molecular characteristics of zoonotic intestinal parasites in stray dogs housed in shelter centers across South Korea were investigated in this study. A total of 846 fecal samples were collected from shelters in the northern, central, southern and Jeju Island regions between 2019 and 2020. PCR analysis identified the presence of Giardia duodenalis (5.4 %), Enterocytozoon bieneusi (1.4 %), Blastocystis sp. (0.1 %), and Cryptosporidium spp. (0.5 %). Phylogenetic analysis further revealed zoonotic genotypes, including assemblages C, D, and F of G. duodenalis; zoonotic group 1 of E. bieneusi; the ST4 subtype of Blastocystis sp.; and C. canis. Notably, this study represents the first report of E. bieneusi and G. duodenalis assemblage F in dogs in South Korea, as well as the ST4 subtype of Blastocystis sp. These findings underscore the potential risk of zoonotic transmission between dogs and humans, particularly in settings characterized by overcrowding and inadequate hygiene, such as animal shelters. The results emphasize the need for routine deworming, enhanced sanitation protocols, and targeted surveillance programs to reduce zoonotic risks. By offering novel epidemiological insights, this research contributes to the advancement of public health and animal welfare efforts. | Lee, You-Jeong; Kim, Beoul; Lee, Gyeonghyeon; Kang, Yong-Myung; Kwak, Dongmi; Seo, Min-Goo | Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, 80 Daehak Ro, Daegu 41566, South Korea | Seo, Min-Goo/NQF-4335-2025 | 59343760600; 59343608800; 59702525900; 57211580286; 7007148758; 53982155300 | koreasmg@knu.ac.kr; | RESEARCH IN VETERINARY SCIENCE | RES VET SCI | 0034-5288 | 1532-2661 | 188 | SCIE | VETERINARY SCIENCES | 2024 | 1.8 | 32.6 | 12.42 | 2025-05-07 | 1 | 1 | Stray dog; Giardia duodenalis; Enterocytozoon bieneusi; Cryptosporidium canis; Blastocystis sp | ENTEROCYTOZOON-BIENEUSI; GIARDIA-DUODENALIS; CRYPTOSPORIDIUM SPP.; GENETIC DIVERSITY; BLASTOCYSTIS; INFECTIONS; CATTLE | Blastocystis sp; Cryptosporidium canis; Enterocytozoon bieneusi; Giardia duodenalis; Stray dog | Animals; Blastocystis; Cryptosporidium; Dog Diseases; Dogs; Enterocytozoon; Feces; Giardia lamblia; Giardiasis; Intestinal Diseases, Parasitic; Phylogeny; Prevalence; Republic of Korea; Zoonoses; adult; animal housing; animal shelter; animal welfare; antihelminthic therapy; Article; Blastocystis; controlled study; crowding (area); Cryptosporidium; Cryptosporidium canis; Enterocytozoon bieneusi; feces; female; genotype; Giardia intestinalis; hygiene; infection risk; intestine parasite; male; molecular diagnosis; monitoring; nonhuman; nucleotide sequence; parasite identification; parasite prevalence; parasitic zoonosis; phylogeny; polymerase chain reaction; public health; risk reduction; sanitation; South Korea; stray dog; zoonotic transmission; animal; Blastocystis; Cryptosporidium; dog; dog disease; Enterocytozoon; epidemiology; genetics; Giardia intestinalis; giardiasis; intestine infection; isolation and purification; parasitology; prevalence; South Korea; veterinary medicine; zoonosis | English | 2025 | 2025-06 | 10.1016/j.rvsc.2025.105620 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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