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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice | Glutamate excitotoxicity is considered as the etiology of stroke and neurodegenerative diseases, namely, Parkinson's disease (PD), Alzheimer's disease (AD), and others. Meanwhile, substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc), a pivotal site in regulating orofacial nociceptive transmission via A delta and C primary afferent fibers, majorly utilize glutamate as the principal excitatory neurotransmitter. Fucoxanthin (FCX), a carotenoid pigment extracted from brown seaweed, possesses various pharmaceutical properties including neuroprotective effect in multiple neuronal populations. To date, the direct activity of FCX on the SG of the Vc has not been extensively clarified. Consequently, we investigated the effect of FCX on excitatory signaling mediated by ionotropic glutamate receptors (iGluRs), using the patch-clamp technique recorded from SG neurons of the Vc. Here, FCX directly acted on glutamate receptors independent of voltage-gated sodium channel and gamma-aminobutyric acid (GABA)A/glycine receptors in the voltage-clamp mode. Specifically, the N-methyl-D-aspartic acid (NMDA)- and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced responses but not the kainic acid receptor (KAR)-mediated response were suppressed by FCX in standard extracellular solution. Additionally, the inhibitory effect of FCX on NMDA currents was repeatable and concentration-dependent. The FCX blockade of NMDA-mediated excitotoxicity was associated with the modulation of Ca2+ response without affecting Na+ ions. The Ca2+-dependent fluorescence intensity of brain slice was reduced in the presence of FCX. Notably, FCX significantly attenuated the spontaneous firing activity of SG neurons. Altogether, these results reveal that FCX may protect SG neurons against glutamate excitotoxicity via primarily regulating Ca2+ response, thereby inhibiting the excitatory signaling induced by NMDA and AMPA receptors (AMPARs). | Le, Nhung Ha Thuy; Park, Seon Ah; Kim, Yu Mi; Ahn, Dong Kuk; Jung, Won; Han, Seong Kyu | Jeonbuk Natl Univ, Inst Oral Biosci, Sch Dent, Dept Oral Physiol, Jeonju, South Korea; Hue Univ, Hue Univ Med & Pharm, Fac Odontostomatol, Hue, Vietnam; Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, Daegu, South Korea; Jeonbuk Natl Univ, Sch Dent, Dept Oral Med, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Inst Oral Biosci, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju 54896, South Korea | Jung, Won/GRN-8894-2022; Le, Nhung/HSB-3982-2023; Kim, Jong/G-7779-2012 | 59653688800; 15077186100; 57816812300; 58950718500; 57203126364; 8046096000 | jungwon@jbnu.ac.kr; skhan@jbnu.ac.kr; | NEURAL PLASTICITY | NEURAL PLAST | 2090-5904 | 1687-5443 | 2025 | 1 | SCIE | NEUROSCIENCES | 2024 | 3.7 | 31.7 | 0 | 2025-05-07 | 0 | 0 | AMPA receptors; calcium; fucoxanthin; glutamate excitotoxicity; NMDA receptors; patch-clamp; substantia gelatinosa neuron | IN-VITRO; EXCITOTOXICITY; MECHANISMS; CELLS | AMPA receptors; calcium; fucoxanthin; glutamate excitotoxicity; NMDA receptors; patch-clamp; substantia gelatinosa neuron | Animals; Calcium; Male; Mice; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substantia Gelatinosa; Trigeminal Caudal Nucleus; Xanthophylls; 4 aminobutyric acid A receptor; AMPA receptor; calcium; calcium ion; fucoxanthin; glutamate receptor; glycine receptor; ionotropic receptor; kainic acid receptor; n methyl dextro aspartic acid receptor; sodium ion; voltage gated sodium channel; AMPA receptor; calcium; fucoxanthin; n methyl dextro aspartic acid receptor; xanthophyll; animal cell; animal experiment; animal model; animal tissue; Article; brain slice; caudal trigeminal nucleus; controlled study; excitotoxicity; female; fluorescence intensity; male; mouse; nonhuman; patch clamp technique; signal transduction; spinal cord nerve cell; substantia gelatinosa; voltage clamp technique; animal; caudal trigeminal nucleus; drug effect; metabolism; nerve cell | English | 2025 | 2025 | 10.1155/np/2553040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparison of Urinary Red Blood Cell Distribution (URD) and Dysmorphic Red Blood Cells for Detecting Glomerular Hematuria: A Multicenter Study | BackgroundThe clinical utility of urinary red blood cell (RBC) distribution (URD) remains limited. This study aimed to compare the diagnostic performance of URD and dysmorphic RBC (dRBC) in a multicenter study.MethodsThis study enrolled 703 patients who visited four tertiary medical centers in Korea. Patients were classified into glomerular diseases with biopsy (N = 169), renal diseases including chronic kidney disease (N = 194), nephrotic syndrome (NS; N = 88), tubulointerstitial diseases (N = 36), acute kidney injury (N = 32), others (N = 10), and extrarenal diseases (N = 174). Renal parameters, urine microscopic examination, urinalysis, and URD assessments were conducted. The diagnostic performances of dRBC and URD were evaluated.ResultsMedian values of both dRBC and URD were significantly elevated in patients with glomerular diseases. URD exhibited a significant correlation with dRBC (r = 0.536) and albumin creatinine ratio (r = 0.186), while no significant correlation was observed with specific gravity (r = -0.03). Among renal diseases, dRBC and URD values were notably higher in patients with NS. The agreement rate between dRBC and URD results was 78.3% (112/143), with 31 instances showing discrepancies. ROC curve analysis comparing glomerular and extrarenal diseases yielded cutoff values of 18% for dRBC and 31.9% for URD, resulting in corresponding areas under the curve (AUC) of 0.79 and 0.83, respectively.ConclusionsURD exhibited a comparable diagnostic performance, as indicated by a similar AUC value to that of dRBC, while offering the added advantage of providing objective and standardizable results. This attribute enhances its utility as a parameter for distinguishing between patients with glomerular hematuria (GH) and those with non-GH. | Lee, A-Jin; Bang, Hae In; Lee, Sun Min; Won, Dongil; Kang, Myung Seo; Choi, Hyun-ji; Lee, In Hee; Jeon, Chang-Ho | Daegu Catholic Univ, Med Ctr, Dept Lab Med, Daegu, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Lab Med, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Lab Med, Yangsan, South Korea; Kyungpook Natl Univ Hosp, Dept Lab Med, Daegu, South Korea; CHA Bundang Med Ctr, Dept Lab Med, Seongnam, South Korea; Kosin Univ, Gospel Hosp, Dept Lab Med, Pusan, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea | 55270163800; 55225195700; 57207065228; 59680925200; 57212583541; 57210311146; 56390538200; 35082040600 | chjeon@cu.ac.kr; | JOURNAL OF CLINICAL LABORATORY ANALYSIS | J CLIN LAB ANAL | 0887-8013 | 1098-2825 | 39 | 5 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2024 | 2.9 | 31.8 | 0 | 2025-05-07 | 0 | 0 | dysmorphic red blood cell; glomerulonephritis; hematuria; urinary red blood cell distribution | DIAGNOSIS; UF-5000 | dysmorphic red blood cell; glomerulonephritis; hematuria; urinary red blood cell distribution | Adult; Aged; Erythrocytes; Erythrocytes, Abnormal; Female; Hematuria; Humans; Kidney Diseases; Kidney Glomerulus; Male; Middle Aged; ROC Curve; Urinalysis; albumin; creatinine; plasma protein; urea; acute kidney failure; adult; aged; area under the curve; Article; cell shape; chronic kidney failure; clinical significance; comparative effectiveness; correlation analysis; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; differential diagnosis; dysmorphic red blood cell; erythrocyte; erythrocyte parameters; estimated glomerular filtration rate; glomerular hematuria; hematuria; human; human cell; intermethod comparison; interstitial nephritis; kidney biopsy; kidney function test; Korea; major clinical study; male; multicenter study; nephrotic syndrome; receiver operating characteristic; tertiary care center; urinalysis; urinary red blood cell distribution; urine sediment; blood; clinical trial; comparative study; diagnosis; erythrocyte; erythrocyte disorder; female; glomerulus; hematuria; kidney disease; middle aged; pathology; procedures; urine | English | 2025 | 2025-03 | 10.1002/jcla.25159 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Review | Current state and future directions of basic research in rheumatoid arthritis | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Despite advances in biologic therapies targeting inflammatory mediators such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, Janus kinase (JAK), and B cells, many patients do not respond adequately, emphasizing the need for deeper insights into RA pathogenesis. Research highlights the intricate interplay of genetic and epigenetic factors driving immune dysregulation. The breakdown of immune tolerance, often initiated in mucosal sites such as the gut, lung, and oral cavity, promotes the citrullination of antigens, leading to anti-citrullinated protein antibody production and subsequent immune activation. Single-cell and multi-omics approaches have shed light on underexplored immune cell types, such as T peripheral helper cells, CD4+/CD8+ cytotoxic T cells, and autoreactive B cells, broadening the understanding beyond traditionally studied Th17, Th1 cells, macrophages, and fibroblast-like synoviocytes. Future basic research in RA should prioritize elucidating the mechanisms behind peripheral tolerance breakdown, the pathogenesis of seronegative RA, and the molecular pathways driving refractory and recurrent disease. Moreover, leveraging multi-omics approaches to dissect disease heterogeneity will be pivotal for advancing personalized treatment strategies and improving long-term outcomes in RA patients. Copyright © The Korean College of Rheumatology. | Ghang, Byeongzu; Park, Jin Kyun; Ju, Ji Hyeon; Han, Seungwoo | Division of Rheumatology, Department of Internal Medicine, Jeju National University Hospital, Jeju National University, School of Medicine, Jeju, South Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National University, College of Medicine, South Korea; Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea | 57190569024; 59658281400; 59946674000; 55246807000 | kiefe73@gmail.com; | Journal of Rheumatic Diseases | J RHEUMAT DIS | 2093-940X | 2233-4718 | 32 | 3 | ESCI | RHEUMATOLOGY | 2024 | 3 | 31.9 | 0 | Anti-citrullinated protein antibody; Disease heterogeneity; Immune dysregulation; Rheumatoid arthritis; Synovial inflammation | CD4 antigen; CD8 antigen; cyclic citrullinated peptide antibody; interleukin 6; Janus kinase; tumor necrosis factor; antibody production; autoimmune disease; B lymphocyte; biological therapy; citrullination; controlled study; cytotoxic T lymphocyte; etiology; fibroblast; helper cell; human; immune dysregulation; immunocompetent cell; immunological tolerance; inflammation; joint destruction; macrophage; major clinical study; multiomics; pathogenesis; review; rheumatoid arthritis; synoviocyte; synovitis; tenosynovitis; Th1 cell; Th17 cell | English | Final | 2025 | 10.4078/jrd.2024.0151 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | A Study on Scratching Behavior Characteristics in Patients With Various Types of Chronic Pruritus | Purpose: In the 'Itch-Scratch cycle', scratching manifests in various ways and further provokes skin inflammation and alteration of the skin microbiota. However, there is an unmet demand for classifying and interpreting scratching behavior. We analyze patterns of scratching behavior expressed by patients with chronic pruritus. Methods: A survey was conducted on 206 adult patients with chronic pruritus for more than six weeks. Participants responded to a questionnaire about pruritus, including standard unidimensional-scale questions, as well as individualistic questions about sensory expression and quality of life. For scratching behavior, all patients answered questions about patterns, tools, situations, time spent, and scratched areas. Exploratory factor analysis was conducted to classify scratching behavior. Descriptive and exploratory factor analyses were used to identify the structure of the underlying factors measured by the questionnaire items. Results: Among pruritic descriptors, 'unbearable' was the most common (84.5%). Of 206 participants, 190 (92.2%) responded that they scratched. The most common itch resolution methods were 'applying moisturizer', 'rubbing', and 'applying ointment'. The fingernails (89.3%) were the most frequently reported tool used for scratching. Participants reported most frequent scratching during sleep or rest. Among the pruritus-specific quality-oflife indicators, 'Lifelong' was the most stressful item related to all scratching behaviors. Regarding scratching differences by disease, patients with prurigo showed shorter scratching time with abnormal and aggressive behavior. Conclusions: We analyzed scratching behavior patterns in patients with chronic pruritus. Our findings support the need for education on the importance of applying moisturizer before sleep. The results are also important for helping patients with prurigo correct their abnormal and aggressive scratching behavior patterns, which can reduce quality of life and worsen symptoms. | Lee, Ji Hyun; Na, Chan Ho; Ryoo, Ji Hoon; Chae, Soo Yuhl; Kim, Jin Ho; Park, Do Young; Bang, Jin Seon; Kim, Esther; Kwak, Jun Ho; Kang, Da Hyun; Lew, Bark-Lynn; Jang, Yong Hyun | Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Dermatol, Seoul, South Korea; Chosun Univ, Coll Med, Dept Dermatol, Gwangju, South Korea; Yonsei Univ, Dept Educ, Seoul, South Korea; BL Plast Surg Clin, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyung Hee Univ, Coll Med, Dept Dermatol, Seoul, South Korea; Kyung Hee Univ, Sch Med, Kyung Hee Univ Hosp Gangdong, Dept Dermatol, 892 Dongnam Ro, Seoul 05278, South Korea | Ryoo, Ji/J-5164-2017 | 57190277285; 59918901800; 56312837100; 56572103500; 58508499500; 59238353300; 57781956500; 58895143600; 58350091100; 58502974800; 6701632121; 59681580200 | bellotte@hanmail.net; yhjang@knu.ac.kr; | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | ALLERGY ASTHMA IMMUN | 2092-7355 | 2092-7363 | 17 | 3 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 4.3 | 32.0 | 0 | 2025-06-11 | 0 | 0 | Compulsive behavior; pruritus; skin | QUALITY-OF-LIFE; INTERNATIONAL FORUM; ATOPIC-DERMATITIS; ITCH; SLEEP; ASSOCIATION; DISORDERS; SEVERITY; IMPACT | Compulsive behavior; pruritus; skin | antipruritic agent; adult; aggression; Article; chronic disease; clinical feature; controlled study; cross-sectional study; dermatitis; exploratory factor analysis; female; finger nail; human; major clinical study; male; multicenter study; prurigo; pruritus; quality of life; rest; scratching; skin flora; sleep | English | 2025 | 2025-05 | 10.4168/aair.2025.17.3.371 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A Conceptual Framework for Planning Road Digital Twins | Digital twin (DT) is an emerging technology gaining traction across various industries. However, its development and application in the architecture, engineering, and construction (AEC) industry remain in their early stage, lagging considerably behind other sectors. This is primarily attributed to the challenges facing the AEC industry, including digital transformation and the lack of formal standards for DT implementation. This study aims to contribute to the conceptualization of DT planning-the early stage of the DT lifecycle-focusing on the road transportation sector, particularly road physical twin planning within the AEC industry. To achieve this, we reviewed the relevant literature defining DT planning. We also examined stakeholders' relevant guidelines and documents from national bodies that roadmap the road DT planning process to understand the scope and identify knowledge gaps. Based on the findings, mapping the existing road planning process to the constituents of road DT planning was performed for the applicable planning steps. Finally, we proposed a five-layered road DT planning framework that will roadmap future implementations comprising data acquisition, data processing, data modeling and algorithms, data analysis and control, and a service layer plus users. In addition, a case study is incorporated to validate the feasibility of the framework toward applying it further in practice. | Buuveibaatar, Munkhbaatar; Brilakis, Ioannis; Peck, Matt; Economides, George; Lee, Wonhee | Kyungpook Natl Univ, Res Inst Artificial Intelligent Diag Technol Multi, Sangju 37224, South Korea; Univ Cambridge, Dept Engn, 7a JJ Thomson Ave, Cambridge CB3 0FA, England; AtkinsRealis, 2 Chamberlain Sq, Birmingham B3 3AX, England; Great Minster House, Dept Transport, 33 Horseferry Rd, London SW1P 4DR, England; Kyungpook Natl Univ, Dept Locat Based Informat Syst, Sangju 37224, South Korea | Brilakis, Ioannis/H-5369-2013; Buuveibaatar, Munkhbaatar/ISU-9533-2023 | 57219182724; 8837673400; 59242018300; 57804927100; 57190774365 | munkh@knu.ac.kr; ib340@cam.ac.uk; matt.peck@atkinsrealis.com; george.economides@dft.gov.uk; wlee33@knu.ac.kr; | BUILDINGS | BUILDINGS-BASEL | 2075-5309 | 15 | 3 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2024 | 3.1 | 32.1 | 0 | 2025-05-07 | 1 | 1 | digital twin; road digital twin; digital twin planning; road digital twin planning framework; digital roads; future roads; digital assets; digital transformation | digital assets; digital roads; digital transformation; digital twin; digital twin planning; future roads; road digital twin; road digital twin planning framework | Data acquisition; Architecture engineering; Digital assets; Digital road; Digital transformation; Digital twin planning; Future road; Planning framework; Road digital twin; Road digital twin planning framework; Roadmap; Data handling | English | 2025 | 2025-02 | 10.3390/buildings15030316 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of an Optimal Machine Learning Model to Predict CO2 Emissions at the Building Demolition Stage | The construction industry accounts for approximately 28% of global CO2 emissions, and emission management at the building demolition stage is important for achieving carbon neutrality goals. Systematic studies on the demolition stage, however, are still lacking. In this study, research on the development of optimal machine learning (ML) models was conducted to predict CO2 emissions at the demolition stage. CO2 emissions were predicted by applying various ML algorithms (e.g., gradient boosting machine [GBM], decision tree, and random forest), based on the information on building features and the equipment used for demolition, as well as energy consumption data. GBM was selected as a model with optimal prediction performance. It exhibited very high accuracy with R2 values of 0.997, 0.983, and 0.984 for the training, test, and validation sets, respectively. The GBM model also showed excellent results in generalization performance, and it effectively learned the data patterns without overfitting in residual analysis and mean absolute error (MAE) evaluation. It was also found that features such as the floor area, equipment, wall type, and structure significantly affect CO2 emissions at the building demolition stage and that equipment and the floor area are key factors. The model developed in this study can be used to support decision-making at the initial design stage, evaluate sustainability, and establish carbon reduction strategies. It enables efficient data collection and processing and provides scalability for various analytical approaches compared to the existing life cycle assessment (LCA) approach. In the future, it is deemed necessary to develop ML tools that enable comprehensive assessment of the building life cycle through system boundary expansion. | Cha, Gi-Wook; Park, Choon-Wook | Kyungpook Natl Univ, Acad Res Digital Convergence Scale Up Platform Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Undeclared Majors, Daegu 41566, South Korea | 55754413300; 56181530400 | cgwgnr@gmail.com; pcw2379@knu.ac.kr; | BUILDINGS | BUILDINGS-BASEL | 2075-5309 | 15 | 4 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2024 | 3.1 | 32.1 | 0 | 2025-05-07 | 0 | 0 | demolition stage; carbon emission; machine learning (ML); waste management (WM); optimal model | CONSTRUCTION WASTE GENERATION; CARBON EMISSION | carbon emission; demolition stage; machine learning (ML); optimal model; waste management (WM) | Adaptive boosting; Decision making; Waste management; Building demolition; Carbon emissions; CO 2 emission; Demolition stage; Gradient boosting; Machine learning; Machine learning models; Machine-learning; Optimal model; Waste management; Demolition | English | 2025 | 2025-02 | 10.3390/buildings15040526 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Information Modeling Application Evaluation Conversion Methodology of Barrier-Free Certification for Safety Design | To improve safety through design, the state can take the initiative in building certification. In this study, we systematically review and review the Barrier-Free (BF) certification evaluation for barrier-free design by implementing information modeling. We developed and applied a BIM-based evaluation template to the evaluation items derived from IPA analysis. As a result of the application, we were able to construct an efficient evaluation sheet by utilizing BIM tools. The results of the study showed that there is a need to improve the BF certification criteria and develop evaluation-related items utilizing BIM functions. This study can be utilized in the future for the development of BIM-based certification criteria for the disabled and the development of evaluation sheets. | Kang, Kyung-Ha; Son, Byeung-Hun; Lee, Hye-Kyoung | Korea Polytech, Dept Architectural Design, Gwangju 61099, South Korea; Daegu Tech Univ, Dept Architecture, Daegu 42734, South Korea; Kyungpook Natl Univ, A3 Architecture Inst, Daegu 41566, South Korea | 57607983100; 56909550800; 57209320452 | archikang@kopo.ac.kr; sonb.hun@gmail.com; lhk@knu.ac.kr; | BUILDINGS | BUILDINGS-BASEL | 2075-5309 | 15 | 7 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2024 | 3.1 | 32.1 | 0 | 2025-05-07 | 0 | 0 | safety design; building certification; barrier-free design; building information modeling; building evaluation system | INCLUSIVE DESIGN | barrier-free design; building certification; building evaluation system; building information modeling; safety design | Architectural design; Barrier-free; Barrier-Free Design; Building certification; Building evaluation system; Building evaluations; Building Information Modelling; In-buildings; Information Modeling; Model application; Safety design; Building Information Model | English | 2025 | 2025-03-21 | 10.3390/buildings15071000 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection | The global spread, frequent antigenic changes, and pandemic potential of clade 2.3.4.4b highly pathogenic avian influenza H5N1 underscore the urgent need for robust cross-protective vaccines. Here, we developed a clade 2.3.4.4b H5N1 whole inactivated virus (WIV) vaccine strain with improved structural stability, productivity, and safety. By analyzing the evolutionary trends of clade 2.3.4.4b H5N1 viruses, we identified a key mutation (R90K) that increases heat stability while preserving antigenicity. Additionally, the PB2 gene of PR8 was replaced with a prototypical avian PB2 gene to increase replication efficiency in embryonated chicken eggs and reduce replication efficiency in mammalian cells, thereby improving productivity and biosafety. We found that our optimized clade 2.3.4.4b H5N1 vaccine strain (22WKY), inactivated with binary ethylenimine (BEI), had superior antigen internalization into respiratory epithelial cells compared to those inactivated with formaldehyde or beta-propiolactone. Following intranasal administration to mice, the BEI-inactivated 22WKY also elicited significantly stronger systemic IgG, mucosal IgA, and T-cell responses, especially in the lungs. Protective efficacy studies revealed that the BEI-inactivated 22WKY vaccine provided complete protection against heterologous viral challenges and significant protection against heterosubtypic viral challenges, with no weight loss and complete suppression of the viral load in the respiratory tract in 2 of 3 mice. These results indicate that the BEI-inactivated 22WKY vaccine could serve as a promising candidate for a safe, stable, cost-efficient, and broadly protective intranasal influenza vaccine against zoonotic and pandemic threats. | Song, Jin-Ha; Son, Seung-Eun; Kim, Ho-Won; Kim, Seung-Ji; An, Se-Hee; Lee, Chung-Young; Kwon, Hyuk-Joon; Choi, Kang-Seuk | Seoul Natl Univ, Coll Vet Med, Lab Avian Dis, 1 Gwanak-Ro, Seoul 88026, South Korea; Anim & Plant Quarantine Agcy, Avian Influenza Res & Diagnost Div, Gimcheon, South Korea; Kyungpook Natl Univ, Coll Med, Dept Microbiol, Daegu, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Coll Vet Med, Seoul, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Farm Anim Med, Lab Poultry Med,BK21 PLUS Vet Sci, 1 Gwanak Ro, Seoul 88026, South Korea; GeNiner Inc, Seoul, South Korea | 57221101773; 57221094613; 58516482000; 58516580700; 57195539685; 57195422071; 57196596247; 35798047900 | kwonhj01@snu.ac.kr; kchoi0608@snu.ac.kr; | VIROLOGY JOURNAL | VIROL J | 1743-422X | 22 | 1 | SCIE | VIROLOGY | 2024 | 3.8 | 32.1 | N/A | 0 | 0 | Highly pathogenic avian influenza virus; Heat stability; Whole inactivated virus vaccine; Binary ethylenimine; Intranasal administration; Cross-protection | A VIRUS; RECEPTOR-BINDING; HEMAGGLUTININ; STABILITY; DELIVERY; PH; IMMUNITY; SYSTEM | Binary ethylenimine; Cross-protection; Heat stability; Highly pathogenic avian influenza virus; Intranasal administration; Whole inactivated virus vaccine | Administration, Intranasal; Animals; Antibodies, Viral; Antigens, Viral; Cross Protection; Female; Influenza A Virus, H5N1 Subtype; Influenza Vaccines; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Vaccines, Inactivated; Virion; bromethol; inactivated vaccine; unclassified drug; whole virion inactivated vaccine; inactivated vaccine; influenza vaccine; virus antibody; virus antigen; A-549 cell line; amino acid sequence; animal experiment; antigenicity; area under the curve; Article; biosafety; cell isolation; clade 2.3.4.4b H5N1 influenza virus; controlled study; cross protection; enzyme linked immunosorbent assay; female; flow cytometry; gene mutation; genetics; HEK293T cell line; immune response; immunization; Influenza A virus (H5N1); LD50; lymphocyte; MDCK cell line; mouse; nonhuman; phylogeny; respiratory system; Sanger sequencing; site directed mutagenesis; spleen cell; TCID50; thermostability; virus load; virus neutralization; Western blotting; animal; Bagg albino mouse; blood; immunology; intranasal drug administration; orthomyxovirus infection; prevention and control; virion; virology | English | 2025 | 2025-05-05 | 10.1186/s12985-025-02760-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Nudge-Based Intervention for Cognitive Enhancement of Elderly in Long-Term Care Facilities During Fire Evacuation According to Urgent-Level Circumstances | The cognitive ability of the elderly significantly influences evacuation performance in urgent situations. Despite its importance, many fire evacuation studies overlook the impact of cognitive ability on elderly evacuation performance. To address this gap, this study employs multicriteria decision-making to identify nudging factors that enhance the cognitive abilities of the elderly during fire evacuations in long-term care facilities. Based on a literature review, key nudging factors include guidance lights, guide lines, handrails, and guidance equipment, with sub-criteria such as location, color, size, and intervals. Experts from academic and practical fields analyzed the nudging factors, followed by a hybrid analytic hierarchy process (AHP-TOPSIS) analysis. The findings emphasize the necessity of providing auditory information through guidance equipment (e.g., voice evacuation system) in high-level scenarios (practice experts AHP: 0.31) and visual information through the continuous installation of guide lines in strategic locations (academic experts AHP: 0.35) to facilitate efficient evacuation. As a result, this study confirms both the differing and concordant opinions among expert groups while recognizing the absolute necessity of elderly evacuation research and considering the unique challenges that prevent actual evacuation experiments with elderly individuals. By synthesizing these perspectives, the study derives the weights and ranks of nudging factors based on urgent-level circumstances, thereby conducting a quantitative assessment of factors that enhance cognitive ability during elderly evacuation. The findings of this study can serve as a basis for future evacuation policy formulation for elderly-related facilities and, as a derivative effect, contribute to ensuring the life safety of elderly individuals within the local community. | Ryu, Jihye; Kim, Sung-Kyung; Lee, Hye-Kyoung; Hong, Won-Hwa; Kim, Young-Chan | Kyungpook Natl Univ, Convergence Inst Construct Environm & Energy Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Architecture Inst A3, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea; Dongguk Univ, Div Smart Safety Engn, WISE, Gyeongju 38066, South Korea | 56192651000; 57196459261; 57209320452; 7401527968; 56463201400 | ryou0407@knu.ac.kr; kimsg1012@knu.ac.kr; lhk@knu.ac.kr; hongwh@knu.ac.kr; yyoungchani@gmail.com; | BUILDINGS | BUILDINGS-BASEL | 2075-5309 | 15 | 8 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2024 | 3.1 | 32.1 | 0 | 2025-05-07 | 0 | 0 | elderly evacuation performance; cognitive ability; nudging factors; fire evacuation; multi-criteria decision making (AHP-TOPSIS) | ANALYTIC HIERARCHY PROCESS; BUILDING EVACUATION; EXIT CHOICE; SYSTEM; BEHAVIOR; SIGNAGE; DESIGN; SAFETY; TIME | cognitive ability; elderly evacuation performance; fire evacuation; multi-criteria decision making (AHP–TOPSIS); nudging factors | Risk perception; Cognitive ability; Elderly evacuation performance; Fire evacuation; Long term care; Multi criteria decision-making; Multi-criteria decision making (AHP–TOPSIS); Multicriteria decision-making; Multicriterion decision makings; Nudging factor; Performance; Guides (mechanical) | English | 2025 | 2025-04-12 | 10.3390/buildings15081269 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer | This study aimed to identify radiotherapy dosimetric parameters related to local failure (LF)-free survival (LFFS) in patients with lung and liver oligometastases from colorectal cancer treated with stereotactic body radiotherapy (SBRT). We analyzed 75 oligometastatic lesions in 55 patients treated with SBRT between January 2014 and December 2021. There was no constraint or intentional increase in maximum dose. LF was defined as the progression of the treated lesion until the last follow-up or death. The dose distributions were recalculated using Monte Carlo-based algorithms. The significance of the planning target volume (PTV) biologically effective dose (BED) 10s (D2, D95, D98, Dmean) in LFFS was evaluated using Cox regression, considering sex, age, primary cancer, tumor site, oligometastatic status, multiplicity, and either tumor size or one of the volume parameters. LF occurred in 23.4% of the lesions. Lesions showing LF received significantly lower PTV D2 (146 +/- 21 vs. 164 +/- 23, p = 0.006). Multivariate analysis revealed that PTV D2 (= 159 Gy(10)) was the sole dosimetric parameter associated with LFFS. Tumors equal to or larger than the median size/volume yet receiving < 159 Gy(10) of PTV D2 showed the lowest LFFS following stratification by median PTV D2 combined with tumor size or volume parameters. The maximum dose (PTV D2) was significantly associated with LFFS after SBRT for lung and liver oligometastases from colorectal cancer. Increasing the maximum dose may be beneficial for managing larger tumors. | Kang, Su Jin; Park, Jongmoo; Choi, Gyu-Seog; Kim, Jong Gwang; Park, Jun Seok; Kim, Hye Jin; Baek, Jin Ho; Kang, Byung Woog; Seo, An Na; Park, Shin-Hyung; Bae, Bong Kyung; Kang, Min Kyu; Park, Soo Yeun | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Oncol Hematol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Pathol, Sch Med, Chilgok Hosp, Daegu, South Korea | Park, Shinhyung/LNQ-6428-2024; Kim, Hye/W-1059-2019; Kang, Min Kyu/AHI-4762-2022 | 58814791100; 56180048900; 8058759100; 59501049300; 35226761100; 57204567554; 57217075847; 28567838500; 55804153700; 57203275843; 57191481610; 57201933342; 40561578300 | mkkang@knu.ac.kr; yeun21c@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 20 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 2.6 | 32.2 | 0 | 2025-05-07 | 0 | 0 | CELL LUNG-CANCER; RADIATION-THERAPY; CLINICAL INTRODUCTION; LIVER METASTASES; GUIDELINE; HISTOLOGY; DISEASE | Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Radiosurgery; Radiotherapy Dosage; Retrospective Studies; capecitabine; fluorouracil; folinic acid; irinotecan; K ras protein; oxaliplatin; adult; aged; algorithm; Article; cancer chemotherapy; cancer prognosis; cancer radiotherapy; cancer staging; chemoradiotherapy; colon cancer; colorectal cancer; computer assisted tomography; disease free survival; dosimetry; dynamic conformal arc; ECOG Performance Status; female; follow up; gross tumor volume; human; image analysis; image processing; immunization; immunosuppressive treatment; intensity modulated beam; intensity modulated radiation therapy; liver metastasis; local failure free survival; lung cancer; major clinical study; male; maximum permissible dose; metastasis; metastatic colorectal cancer; microsatellite instability; Monte Carlo cross validation; mutation; oncological parameters; outcome assessment; overall survival; planning target volume; prescription; radiation dose; radiation dose distribution; rectum cancer; retrospective study; risk factor; static conformal beam; stereotactic body radiation therapy; survival rate; systemic therapy; tumor burden; tumor growth; tumor localization; tumor volume; colorectal tumor; liver tumor; lung tumor; metastasis; middle aged; pathology; procedures; radiosurgery; radiotherapy; radiotherapy dosage; very elderly | English | 2025 | 2025-01-03 | 10.1371/journal.pone.0313438 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Hosta clausa (Asparagaceae) in East Asia: Intraspecific chloroplast genome variation and its phylogenomic implications | Hosta species are abundant in northeastern Asia, offering significant ornamental and horticultural value due to their diverse foliage colors and textures, as well as their showy, fragrant flowers. Among the eight taxa naturally distributed in Korea, H. clausa is found in central and northern Korea, as well as northeastern China, providing valuable resources for developing and improving new varieties. Currently, four intraspecific taxa of H. clausa are recognized at the variety level based on reproductive (opened vs. closed perianth), vegetative (leaf shape), and habitat characteristics: var. clausa, var. normalis, var. ensata, and var. geumgangensis. Despite its horticultural and taxonomic importance, little is known about the degree of intraspecific chloroplast genome variation and relationships among the varieties of H. clausa. This could provide some valuable information for marker-assisted breeding programs and molecular cultivar identification. In this study, we investigated the complete plastid genome of 14 accessions of H. clausa, covering its native distribution range. We characterized genome size and features and performed comparative plastome analyses (frequency of codon usage, nucleotide diversity, mutation hotspots). Our analysis revealed highly conserved structures and gene content organization in H. clausa, along with significantly (two to three times) lower nucleotide diversity compared to intraspecific herbaceous and woody species. The phylogenetic analysis did not support the recognition of intraspecific taxa as currently delimited, and a broad-scale geographical structure of complete plastomes was not apparent. The asexual reproductive mode of H. clausa appears to contribute to the low plastome genetic diversity. A total of 72 polymorphic sites identified among 14 accessions of H. clausa and their phylogenetic relationships, in conjunction with their geographical distribution and morphological characteristics, will be a valuable resource for barcoding study, marker-assisted breeding programs, and developing conservation strategies for hosta species in East Asia. | Yang, Jiyoung; Kim, Seung-Chul | Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu, South Korea; Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea | 55193226000; 57214983739 | sonchus96@skku.edu; | PLOS ONE | PLOS ONE | 1932-6203 | 20 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 2.6 | 32.2 | 4.56 | 2025-05-07 | 1 | 1 | SEQUENCE; ALIGNMENT; TOOLS | Asia, Eastern; Genetic Variation; Genome, Chloroplast; Hosta; Phylogeny; methionine; tryptophan; Article; Asparagaceae; breeding; chloroplast genome; DNA extraction; DNA isolation; DNA sequence; foliage; habitat; Hosta; Hosta clausa; morphology; phylogenetic tree; phylogenomics; plastid genome; single nucleotide polymorphism; Far East; genetic variation; genetics; Hosta; phylogeny | English | 2025 | 2025-02-19 | 10.1371/journal.pone.0317884 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Rethinking food loss and waste to promote sustainable resource use and climate change mitigation in agri-food systems: A review | The sustainable agri-food system is an important sector recognized for promoting the United Nations' Sustainable Development Goals on food security, resource conservation and climate change mitigation. However, the increasing food loss and waste (FLW) along the supply chains has continued to hinder these goals. This study evaluates the trend of FLW research from 1975 to 2022 and how it promotes the achievement of resource and environmental sustainability in agri-food systems. The salient research themes and hotspots that are of interest to researchers were identified. Bibliometric and network analyses were carried out on scholarly research articles from the Scopus database using bibliometrix and VOSviewer. Furthermore, the content analysis was conducted on the selected highly influential articles containing relevant data to understand the role of FLW in promoting sustainable agri-food systems. The results showed disaggregate and unbalanced research distribution on the impacts of FLW among the countries, with China and the United States having the highest contributions. The identified major research themes relating to sustainable agri-food systems are food waste and sustainable systems, food waste management and food waste impact assessment. Moreover, the circular economy was found to be a relatively new approach being explored in agri-food systems to promote FLW reduction and ensure sustainability of resource use. This study highlights the critical role of the impact of FLW in addressing the grand challenge of food security, resource use efficiency and environmental sustainability. | Adelodun, Bashir; Agbelusi, Oyebankole O.; Soma, Tammara; Odey, Golden; Adeyi, Qudus; Kumar, Pankaj; Ajibade, Fidelis Odedishemi; Goala, Madhumita; Silva, Luis Felipe Oliveira; Mostafa, Yasser S.; Singh, Rattan; Choi, Kyung Sook; Eid, Ebrahem M. | Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, Ilorin, Nigeria; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; African Dev Bank, RDNG, Safeguards & Compliance Dept SNSC, Abuja, Nigeria; Simon Fraser Univ, Sch Resource & Environm Management, Burnaby, BC, Canada; Gurukula Kangri Deemed Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar, India; Fed Univ Technol Akure, Dept Civil & Environm Engn, Akure, Nigeria; Graph Era Deemed Univ, Dept Environm Sci, Dehra Dun, India; Univ De La Costa, Dept Civil & Environm Engn, Barranquilla, Atlantico, Colombia; King Khalid Univ, Coll Sci, Biol Dept, Abha, Saudi Arabia; Guru Jambheshwar Univ Sci & Technol, Dept Food Technol, Hisar, India; Kafrelsheikh Univ, Fac Sci, Bot Dept, Kafr Al Sheikh 33516, Egypt | Eid, Ebrahem/O-2723-2013; Adelodun, Bashir/O-2941-2018; Ajibade, Fidelis/D-7893-2019; Odey, Golden/MVV-6310-2025; Singh, Rattan/NFS-9869-2025; Kumar, Pankaj/B-2854-2016 | 57193774482; 59240521900; 57190267343; 57211444984; 58672628000; 57281192700; 57190341647; 57221943148; 57192545865; 7003876227; 55496963700; 54392662900; 35794350700 | adelodun.b@unilorin.edu.ng; ks.choi@knu.ac.kr; ebrahem.eid@sci.kfs.edu.eg; | WASTE MANAGEMENT & RESEARCH | WASTE MANAGE RES | 0734-242X | 1096-3669 | 43 | 4 | SCIE | ENVIRONMENTAL SCIENCES;ENGINEERING, ENVIRONMENTAL | 2024 | 4.3 | 32.2 | 5.94 | 2025-05-07 | 4 | 6 | Agri-food systems; food loss and waste; environmental sustainability; resources use; waste management | GREENHOUSE-GAS EMISSIONS; ENVIRONMENTAL-IMPACT; SUPPLY CHAINS; FRAMEWORK; SURPLUS; WATER; CONSUMPTION; CHALLENGES; HOUSEHOLDS; CARBON | Agri-food systems; environmental sustainability; food loss and waste; resources use; waste management | Agriculture; Climate Change; Conservation of Natural Resources; Food; Food Loss and Waste; Food Security; Food Supply; Sustainable Development; Waste Management; China; United States; Climate change; Conservation; Food supply; Supply chains; Sustainable development; Agri-food system; Climate change mitigation; Environmental sustainability; Food loss; Food security; Food waste; Resource conservation; Resource use; Sustainable resource use; United Nations; climate change; food security; food waste; mitigation; resource use; sustainability; waste management; bibliometrics; climate change mitigation; content analysis; economic aspect; environmental sustainability; food; food security; food waste; human; network analysis; review; sustainable development goal; United States; waste management; agriculture; catering service; climate change; environmental protection; food; food waste; procedures; sustainable development; Waste management | English | 2025 | 2025-04 | 10.1177/0734242x241257655 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Simulation study for the energy and position reconstruction performances of the beam monitoring system of Carbon Ion Radiation Therapy using GEANT4 | Carbon Ion Radiation Therapy is operated in several countries because of its advantage to have high dose concentration and/or high linear energy transfer (LET). To estimate the beam performance of Carbon Ion Radiation Therapy, we target the 1% energy and 1 mm2 position resolutions of the beam monitoring system. The beam monitoring system consists of a scintillation crystal and fiber hodoscope. The scintillation crystal is 20 x 20 x 120mm3 and its candidates are LYSO, CsI and BGO. The fiber hodoscope is composed of 1 mm thickness scintillation fibers and the fibers are arranged vertically for 2D reconstruction. With GEANT4 simulation, we verify the performance of our beam monitoring system. The energy response of the LYSO and BGO scintillators is linear within +/- 2%. The energy resolution of each crystal candidate achieves the goal; LYSO (0.061%), CsI (0.20%) and BGO (0.10%). The position is reconstructed via fiber hodoscope within 5% uncertainty. | Eo, Yun; Kwon, Na Hye; Bae, Joonsuk; Cheon, Byunggu; Cho, Guk; Choi, Suyong; Do, Hyunsuk; Ha, Seungkyu; Huh, Changgi; Hwang, Kyuyeong; Jang, Haeun; Jang, Seoyun; Jang, Yoonjun; Jeong, Jinryong; Kim, Beomkyu; Kim, Bobae; Kim, Dongwoon; Kim, Sungwon; Ko, Sanghyun; Lee, Hyupwoo; Lee, Hyungjun; Lee, Jason; Lee, Junghyun; Lee, Sehwook; Lee, Woochan; Lee, Yunjae; Lim, Sanghoon; Park, Hyesung; Ryu, Jaehyeok; Kim, Jin Sung; Ryu, Min Sang; Yoo, Hwidong; Kim, Dong Wook; Kim, Minsuk | Yonsei Univ, Dept Phys, Seoul, South Korea; Yonsei Univ, Coll Med, Heavy Ion Therapy Res Inst, Dept Radiat Oncol,Yonsei Canc Ctr, Seoul, South Korea; Sungkyunkwan Univ, Dept Phys, Seoul, South Korea; Hanyang Univ, Dept Phys, Seoul, South Korea; Korea Univ, Dept Phys, Seoul, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Gangneung Wonju Natl Univ, Dept Math & Phys, Kangnung, South Korea; Seoul Natl Univ, Dept Phys, Seoul, South Korea; Univ Seoul, Dept Phys, Seoul, South Korea; Kyungpook Natl Univ, Ctr High Energy Phys, Daegu, South Korea | Kim, Dong Wook/I-8636-2014; Kim, Dongwook/KFS-1381-2024; choi, suyong/MXM-2980-2025; Lee, Jason/B-9701-2014 | 59640987700; 57206900810; 58165554700; 35271166300; 58982939000; 25622931500; 59543103000; 57909666100; 57207913151; 57733235100; 59542805600; 59542904100; 59543508500; 59542805700; 57226298441; 57218992867; 59543300600; 55924035800; 57217020012; 59542904200; 8695639100; 57943807000; 57208715587; 59815757800; 59543198000; 35779825700; 55539124000; 58494001800; 56517458800; 56125422300; 58633968700; 57908443200; 57206100905; 58847024000 | KDW1026@yuhs.ac; minsuk@gwnu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 20 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 2.6 | 32.2 | 0 | 2025-05-07 | 0 | 0 | Computer Simulation; Heavy Ion Radiotherapy; Humans; Linear Energy Transfer; Scintillation Counting; bismuth germanate; unclassified drug; Article; calibration; cost; energy; geant4 simulation; geometry; human; ion therapy; linear energy transfer; mathematical analysis; mathematical phenomena; physics; position reconstruction; scintillation; simulation; thickness; uncertainty; computer simulation; devices; procedures; scintillation counting | English | 2025 | 2025-02-04 | 10.1371/journal.pone.0313862 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Zero inflated high dimensional compositional data with DeepInsight | Through the Human Microbiome Project, research on human-associated microbiomes has been conducted in various fields. New sequencing techniques such as Next Generation Sequencing (NGS) and High-Throughput Sequencing (HTS) have enabled the inclusion of a wide range of features of the microbiome. These advancements have also contributed to the development of numerical proxies like Operational Taxonomic Units (OTUs) and Amplicon Sequence Variants (ASVs). Studies involving such microbiome data often encounter zero-inflated and high-dimensional problems. Based on the need to address these two issues and the recent emphasis on compositional interpretation of microbiome data, we conducted our research. To solve the zero-inflated problem in compositional microbiome data, we transformed the data onto the surface of the hypersphere using a square root transformation. Then, to solve the high-dimensional problem, we modified DeepInsight, an image-generating method using Convolutional Neural Networks (CNNs), to fit the hypersphere space. Furthermore, to resolve the common issue of distinguishing between true zero values and fake zero values in zero-inflated images, we added a small value to the true zero values. We validated our approach using pediatric inflammatory bowel disease (IBD) fecal sample data and achieved an area under the curve (AUC) value of 0.847, which is higher than the previous study's result of 0.83. | Lee, Jeseok; Kim, Byungwon | Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | 59167702000; 57205674498 | byungwonkim@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 20 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 2.6 | 32.2 | 0 | 2025-05-07 | 0 | 0 | OPERATIONAL TAXONOMIC UNITS; MICROBIOME; OBESITY | Child; High-Throughput Nucleotide Sequencing; Humans; Inflammatory Bowel Diseases; Microbiota; Neural Networks, Computer; RNA 16S; area under the curve; Article; convolutional neural network; gastroenterology; genomics; high dimensional compositional data; high throughput sequencing; human; image segmentation; inflammatory bowel disease; k fold cross validation; microbiome; operational taxonomic unit; principal component analysis; transcriptomics; artificial neural network; child; genetics; microbiology; microflora; procedures | English | 2025 | 2025-04-16 | 10.1371/journal.pone.0320832 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | From Soil to Salad: Strategies for Reducing Foodborne Illness Outbreaks | This study addresses the global issue of foodborne illness, specifically focusing on those resulting from the consumption of leafy green vegetables. It explores the rising trend of consuming minimally processed or raw foods and the imperative of maintaining safety standards starting at the preharvest stage to prevent pathogenic bacterial contamination. The study identifies soil and irrigation water as key sources of pathogens and emphasizes the need for strict preventive measures during production and preharvest. It discusses the challenges of postharvest decontamination and highlights the importance of early-stage prevention strategies. The paper also examines advanced pathogen detection methods and food safety practices recommended by USDA and FSMA's PSR, including HACCP and LGMA strategies. Aimed at providing insights for consumers and producers, the study underscores the necessity of effective manufacturing strategies to ensure the safety of leafy greens. | Bimal Sheth, Ukti; Haque, Md Ariful; Jang, Min Ji; Haruna, Samuel; Johnston, Tony V.; Choe, Deokyeong; Gao, Ying; Ku, Seockmo | Tennessee Dept Agr, Consumer & Ind Serv, Nashville, TN USA; Texas A&M Univ, Dept Food Sci & Technol, College Stn, TX 77840 USA; Middle Tennessee State Univ, Coll Basic & Appl Sci, Sch Agr, Murfreesboro, TN USA; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu, South Korea | ; Choe, Deokyeong/C-7173-2011; Haque, Md Ariful/J-7282-2019 | 59461038900; 57189583022; 59212677300; 56337017800; 57202011983; 37074453400; 55731388500; 37561670700 | seockmo.ku@ag.tamu.edu; | FOOD SCIENCE & NUTRITION | FOOD SCI NUTR | 2048-7177 | 13 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 3.8 | 32.3 | 3.44 | 2025-05-07 | 2 | 2 | agricultural water; foodborne illness; leafy green; pathogen; soil | MICROBIAL QUALITY; FRESH PRODUCE; WATER; PATHOGENS; SARS-COV-2; CHLORINE; HAZARDS; SAFETY | agricultural water; foodborne illness; leafy green; pathogen; soil | English | 2025 | 2025-01 | 10.1002/fsn3.4521 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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