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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Hyperspectral anomaly detection using Taylor expansion and weighted irregular block filter | Hyperspectral anomaly detection (HAD) is a fundamental task in remote sensing image processing to identify anomalous targets that differ from the background spectrum. However, the interference of local background in hyperspectral images (HSIs) can lead to high false alarm rates in the detection results. We proposed a novel HAD method based on Taylor expansion and weighted irregular block filter (WIBF) to address this issue. First, to the best of our knowledge, we first introduced a single-pixel-based Taylor expansion method into the field of HAD to capture the different spectral features of the HSI. Second, a three-dimensional (3D) hyperspectral feature pyramid was constructed to extracted the feature image of the enhanced image. Third, a WIBF method was proposed to filter the feature image to suppress local background and preserve anomaly information. Fourth, an adaptive dual weight fusion method was proposed for the weighted fusion of the energy images to suppress noise and background. Finally, anomaly detection results were extracted from the reconstructed HSI, which was obtained by the inverse Taylor expansion. Experiments conducted on synthetic and real-world datasets demonstrated the effectiveness and superiority of the proposed method. | Xiang, Pei; Zhang, Jiajia; Qi, Shuxia; Jung, Soon Ki; Zhou, Huixin; Zhao, Dong | Xidian Univ, Sch Phys, Xian 710071, Peoples R China; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Wuxi Univ, Jiangsu Prov Engn Res Ctr Integrated Circuit Relia, Wuxi 214105, Peoples R China | Zhao, Dong/KFA-7114-2024 | 57208546864; 57214900846; 59548426700; 57226791905; 7404743079; 57735571900 | hxzhou@mail.xidian.edu.cn; dzhao@cwxu.edu.cn; | INFRARED PHYSICS & TECHNOLOGY | INFRARED PHYS TECHN | 1350-4495 | 1879-0275 | 150 | SCIE | INSTRUMENTS & INSTRUMENTATION;OPTICS;PHYSICS, APPLIED | 2024 | 3.4 | 30.8 | 0 | 2025-06-11 | 0 | 0 | Hyperspectral image; Anomaly detection; Taylor expansion; Weighted irregular block filter | LOW-RANK; COLLABORATIVE REPRESENTATION | Anomaly detection; Hyperspectral image; Taylor expansion; Weighted irregular block filter | Image enhancement; Salt and pepper noise; Anomaly detection; Background spectrum; False alarm rate; Feature images; HyperSpectral; Hyperspectral anomaly detection; Hyperspectral image; Remote sensing image processing; Taylor's expansion; Weighted irregular block filter; Photointerpretation | English | 2025 | 2025-11 | 10.1016/j.infrared.2025.105942 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Perspective distortion correction in a compact, full-color holographic stereogram printer | Holography technology has advanced so much that it is now possible to record the object wavefront information on thin holographic recording media. Holographic stereogram printing techniques capture numerous 'hogels'-the smallest unit in holographic printing-storing an extensive range of optical information that surpasses the capabilities of other holographic applications. In this paper, we design a compact holographic stereogram printer that utilizes optical fibers to achieve significant system miniaturization. Specifically, the integration of polarization maintaining/single mode (PM/SM) fibers allows for the customization of the printer's optical path. However, due to the wide field of view of our holographic stereograms, perspective distortion is hard to be avoided especially when the wavelengths or positions of the light source are not the same as designed values. The flat transverse plane is bent if the light source deviates from the optical axis. This distortion is easily understood by using a k-vector diagram, which illustrates how the direction of the outgoing light's k-vector changes when it is diffracted by the grating vector of the volume hologram due to the incident light with undesirable direction. In this paper, the feasibility of our perspective-distortion correction algorithm is experimentally demonstrated. | Jeon, Hosung; Kim, Youngmin; Hahn, Joonku | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Elect Technol Inst, Hologram Res Ctr, 8 Floor,11 World Cup Buk Ro 54 Gil, Seoul 03924, South Korea | 56663784700; 57221435538; 10142501600 | jhahn@knu.ac.kr; | DISPLAYS | DISPLAYS | 0141-9382 | 1872-7387 | 88 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;OPTICS | 2024 | 3.4 | 30.8 | 0 | 2025-05-07 | 0 | 0 | Holographic stereogram; Hologram printer; Color holography; Distortion compensation | ENHANCEMENT; DISPLAY | Color holography; Distortion compensation; Hologram printer; Holographic stereogram | Color printing; Electron holography; Holographic gratings; Laser beams; Lithography; Polarization-maintaining fiber; Printing presses; Stereo image processing; Vectors; Color holography; Distortion compensation; Distortions corrections; Full color; Hologram printer; Holographic recording medium; Holographic stereogram; Perspective distortion; Printing techniques; Smallest unit; Holograms | English | 2025 | 2025-07 | 10.1016/j.displa.2025.103051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Determinants of Continuance Intention toward Activity-Based Events Using a Virtual Experience Platform (VEP) | The COVID-19 pandemic compelled traditional in-person events to begin transforming into more innovative and safer experiences by utilizing various virtual experience platforms (VEP). This study explores the salient determinants affecting the self-paced hiking or race event attendees' intention to continue attending the event through the use of VEP based on two robust theories: the expectation-confirmation model (ECM) and the unified theory of acceptance and use of technology (UTAUT2) model. Data were collected from 243 event attendees of a self-paced hiking event in South Korea and analyzed using a PLS-SEM approach. The results of this study demonstrate that performance expectancy had the most significant effect on the event attendees' continuance intention to use VEP, followed by satisfaction, hedonic motivation, and price value. The implications of these findings for event firms and organizations utilizing VEP are discussed. | Kim, Sung-Eun; Kim, Hyelin (Lina); Jung, Shinyong; Uysal, Muzaffer | Kyungpook Natl Univ, Dept Tourism, Sangju, South Korea; Univ Nevada, William F Harrah Coll Hospitality, Las Vegas, NV 89557 USA; Purdue Univ, White Lodging JW Marriott Jr Sch Hospitality & Tou, W Lafayette, IN USA; Univ Massachusetts Amherst, Dept Hospitality & Tourism Management, Amherst, MA USA | Jung, Shinyong (Shawn)/ABE-5406-2020 | 57193428401; 56324575700; 57189716581; 7006287365 | hyelin.kim@unlv.edu; | LEISURE SCIENCES | LEISURE SCI | 0149-0400 | 1521-0588 | 47 | 5 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM;SOCIOLOGY | 2024 | 1.9 | 30.8 | 7.66 | 2025-06-11 | 9 | 16 | Continuance intention; expectation-confirmation model (ECM); unified theory of acceptance and use of technology (UTAUT2) model; Virtual experience platform | INFORMATION-TECHNOLOGY; CONSUMER ACCEPTANCE; UNIFIED THEORY; E-SERVICE; MODEL; PRICE; SATISFACTION; TOURISM; PERCEPTIONS; CUSTOMERS | Continuance intention; expectation–confirmation model (ECM); unified theory of acceptance and use of technology (UTAUT2) model; Virtual experience platform | South Korea; modeling; virtual reality | English | 2025 | 2025-07-04 | 10.1080/01490400.2023.2172116 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Therapeutic potential of novel phages with antibiotic combinations against ESBL-producing and carbapenem-resistant Escherichia Coli | Objectives: The emergence of extended-spectrum beta-lactamase (ESBL)-producing E. coli and carbapenemresistant E. coli (CREC) is a significant global health challenge. This study focuses on isolating and characterizing two novel phages, EC.W1-9 and EC.W15-4, and investigating their efficacy with antibiotics against these resistant E. coli . Methods: In vivo experiments were conducted using BALB/c mice, and E.coli isolates were collected, cultured, and evaluated for antibiotic susceptibility. Phages were isolated from hospital sewage and prepared to infect the E. coli . Results: The isolated phages, EC.W1-9 and EC.W15-4, belonged to the Podoviridae and Straboviridae families, and lack integrase or toxin-coding genes, indicating safety for therapeutic use. The combination of these phages significently enhanced their lytic ability, lysing 61.7% of 60 E. coli isolates, compared to 41.6%-55% lysis by individual phages. Furthermore, the phage combination demonstrated 100% susceptibility against different E. coli sequence types, including ST73, ST648, ST2311, ST405, ST7962, ST131, ST13003, and ST167. Additionally, synergy between antibiotics and phage combinations improved susceptibility rates to 73.3% for ESBL producers and 54% for CREC. The combined treatment of isolated phages and antibiotics significantly increased survival rates in BALB/c mice exposed to resistant STs of E.coli , including ST131, ST648, and ST410. Survival rates against ST131 increased by approximately 75% and 50% compared to treatment individual phages. Combined treatment with two phages and antibiotics resulted in 75-100% survival against E. coli ST410 and 100% survival against ST648 Conclusions: This study highlights the therapeutic importance of phage and phage-antibiotic combinations in combating ESBL-producing E. coli and CREC isolates. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | Shamsuzzaman, Md; Kim, Shukho; Kim, Jungmin | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea | 58493605500; 24341187900; 57211297681 | minkim@knu.ac.kr; | JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | J GLOB ANTIMICROB RE | 2213-7165 | 2213-7173 | 43 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 31.0 | 0 | 2025-06-11 | 1 | 1 | Esbl-producing and cr e. coli; Phage combination; Phage-antibiotic synergism; Sequence type; Therapeutic efficiency | SPECTRUM BETA-LACTAMASES; BACTERIOPHAGE | Esbl-producing and cr e. coli; Phage combination; Phage-antibiotic synergism; Sequence type; Therapeutic efficiency | agar; amikacin; aminoglycoside antibiotic agent; aminopenicillin; amoxicillin; ampicillin; antibiotic agent; aztreonam; bacteriophage DNA; carbapenem derivative; cefazolin; cefepime; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; cephalosporin derivative; ciprofloxacin; colistin; extended spectrum beta lactamase; gentamicin; imipenem; integrase; levofloxacin; linezolid; meropenem; monobactam derivative; oxazolidinone derivative; piperacillin; quinoline derived antiinfective agent; sulfonamide; tetracycline; tigecycline; tobramycin; trimethoprim; animal experiment; animal model; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; Article; bacteriophage; bacterium culture; carbapenem resistant Escherichia coli; comparative study; controlled study; Escherichia coli; extended spectrum beta lactamase producing Escherichia coli; genetic variability; growth curve; hospital wastewater; in vivo study; minimum inhibitory concentration; mouse; multilocus sequence typing; nonhuman; pH; Podoviridae; sewage; survival rate; synergistic effect; thermostability | English | 2025 | 2025-06 | 10.1016/j.jgar.2025.04.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Ferroptosis in neutrophils | Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated fatty acids, are susceptible to peroxidation, leading to the formation of lipid peroxides. Iron metabolism plays a critical role, as excessive free iron catalyzes the production of reactive oxygen species via the Fenton reaction, further promoting lipid peroxidation. Antioxidative mechanisms, including glutathione peroxidase 4 and other components of the glutathione system, are crucial for neutralizing lipid peroxides and preventing ferroptosis. Recent studies have highlighted the role of ferroptosis in neutrophils, particularly under pathological conditions. Neutrophils, due to their high iron content and abundance of polyunsaturated fatty acids, are inherently predisposed to ferroptosis. Recent studies indicate that polymorphonuclear myeloid-derived suppressor cells and tumor-infiltrating neutrophils exhibit high susceptibility to ferroptosis due to a dysregulated antioxidant defense mechanism through hypoxia-mediated downregulation of glutathione peroxidase 4. Conversely, tumor-infiltrating neutrophils resist ferroptosis through nuclear factor erythroid 2-related factor 2-dependent antioxidant pathway. Moreover, neutrophils induce ferroptosis in various cell types, such as endothelial cells, smooth muscle cells, and cardiomyocytes, through the release of neutrophil extracellular traps. This neutrophil extracellular trap-mediated ferroptosis contributes to the pathogenesis of conditions such as intestinal ischemia-reperfusion injury, aortic aneurysm, acute lung injury, and doxorubicin-induced cardiotoxicity. This review consolidates current knowledge on the mechanisms of ferroptosis in neutrophils and its implications in disease progression and immune regulation. Understanding these processes may provide new therapeutic targets for modulating immune responses and improving outcomes in ferroptosis-related diseases. Despite susceptibility to ferroptosis, neutrophils exhibit robust resistant to ferroptosis through antioxidant mechanisms. | Lee, Yu-Bin; Shin, Hyeong-Wook; Shrestha, Sanjeeb; Kim, Jun-Kyu; Jung, Soo-Jung; Shin, Min-Sang; Hong, Chang-Won | Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; ExoStemTech Inc, Ansan 15588, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu 41944, South Korea | Hong, Chang-Won/L-1272-2015 | 57219808197; 59912009200; 57059866700; 57192897853; 57193347340; 7401536650; 55567018400 | cwhong@knu.ac.kr; | JOURNAL OF LEUKOCYTE BIOLOGY | J LEUKOCYTE BIOL | 0741-5400 | 1938-3673 | 117 | 5 | SCIE | CELL BIOLOGY;HEMATOLOGY;IMMUNOLOGY | 2024 | 3.1 | 31.1 | 0 | 2025-06-11 | 0 | 0 | antioxidant defense; ferroptosis; lipid peroxidation; neutrophils | PEROXIDATION | antioxidant defense; ferroptosis; lipid peroxidation; neutrophils | Animals; Ferroptosis; Humans; Iron; Lipid Peroxidation; Neutrophils; Reactive Oxygen Species; antioxidant; doxorubicin; fatty acid; glutathione; iron; lipid peroxide; phospholipid hydroperoxide glutathione peroxidase; polyunsaturated fatty acid; reactive oxygen metabolite; transcription factor Nrf2; acute lung injury; adverse drug reaction; cardiotoxicity; down regulation; endothelium cell; fatty acid metabolism; Fenton reaction; ferroptosis; human; human cell; hypoxia; immune response; immunoregulation; intestine ischemia; iron metabolism; lipid peroxidation; myeloid-derived suppressor cell; neutrophil; neutrophil extracellular trap; nonhuman; regulated cell death; reperfusion injury; review; smooth muscle cell; animal; immunology; lipid peroxidation; metabolism; pathology | English | 2025 | 2025-05 | 10.1093/jleuko/qiaf039 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Randomized Multicenter Study to Evaluate the Efficacy and Safety of Fexuprazan According to the Timing of Dosing in Patients With Erosive Esophagitis | Background/Aims Fexuprazan, a novel potassium-competitive acid blocker, was developed for treating acid-related disorders. Pharmacokinetic and pharmacodynamic properties of fexuprazan, unlike those of proton pump inhibitors, are independent of food effect. This study aims to evaluate differences in efficacy and safety of fexuprazan in patients with erosive esophagitis (EE) according to the timing of dosing. Methods In this multicenter, open-label noninferiority study, patients who had typical reflux symptoms with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg daily 30 minutes before or after meal. Treatment was completed after 2 weeks or 4 weeks when healing was endoscopically confirmed. The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy up to week 4. Safety endpoints included treatment-emergent adverse events (TEAEs). Results In the prior-to-meal group (n = 89) and after-meal group (n = 86), 4-week EE healing rates were 98.77% and 100.00% (difference, 0.01%; 95% CI, -0.01% to 0.04%) and 2-week EE healing rates were 95.77% and 97.14% (difference, 0.01%; 95% CI, -0.05% to 0.07%), respectively. TEAEs were 9.78% and 8.70% in the prior-to-meal group and the after-meal group, respectively. Conclusions Non-inferiority analysis revealed that taking fexuprazan after meal was non-inferior to taking fexuprazan before meals in patients with EE. The frequency of adverse events was similar between the 2 study groups. The drug is safe and effective for healing EE regardless of the timing of dosing. | Lee, Sang Pyo; Sung, In-Kyung; Lee, Oh Young; Choi, Myung-Gyu; Huh, Kyu Chan; Jang, Jae-Young; Chun, Hoon Jai; Kwon, Joong-Goo; Kim, Gwang Ha; Kim, Nayoung; Rhee, Poong-Lyul; Kim, Sang Gyun; Jung, Hwoon-Yong; Lee, Joon Seong; Lee, Yong Chan; Jung, Hye-Kyung; Kim, Jae Gyu; Kim, Sung Kook; Sohn, Chong-il | Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Konkuk Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Konyang Univ, Coll Med, Dept Internal Med, Daejeon, South Korea; Kyung Hee Univ, Med Ctr, Dept Internal Med, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Seoul, South Korea; Daegu Catholic Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Digest Dis Ctr, Seoul, South Korea; Severance Hosp, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea | ; Kim, Nayoung/J-5387-2012; Choi, Myung-Gyu/D-6079-2014; Rhee, Poong/C-9655-2011 | 59905800600; 57838636300; 59735672200; 16635388700; 59913566900; 57215881098; 59074086000; 59638535500; 59682778300; 59295316300; 59911078800; 56371524600; 59734058300; 59095116400; 59735672300; 59913954500; 59903059500; 59784027600; 59914357300 | inksung@kuh.ac.kr; | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | J NEUROGASTROENTEROL | 2093-0879 | 2093-0887 | 31 | 1 | SCIE | CLINICAL NEUROLOGY;GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.3 | 31.1 | 0 | 2025-06-11 | 0 | 0 | Esophagitis; Gastroesophageal reflux; Potassium-competitive acid blocker; Proton Pumps | GASTROESOPHAGEAL-REFLUX DISEASE; ESOMEPRAZOLE; TRIAL | Esophagitis; Gastroesophageal reflux; Potassium-competitive acid blocker; Proton Pumps | creatine kinase; fexuprazan; liver enzyme; potassium competitive acid blocker; abdominal distension; abdominal pain; acute heart infarction; adult; aged; Article; clinical evaluation; clinical outcome; constipation; controlled study; coronavirus disease 2019; diarrhea; dose time effect relation; drug efficacy; drug safety; endoscopy; erosive gastritis; female; food drug interaction; headache; healing rate; human; incidence; insomnia; ligament rupture; major clinical study; male; meal; medication compliance; multicenter study; nausea; non-inferiority trial; open study; outcome assessment; postprandial state; randomized controlled trial; rash; reflux esophagitis; side effect; xerostomia | English | 2025 | 2025-01 | 10.5056/jnm24032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A randomized, active-controlled, multicenter, phase 3 clinical trial to evaluate the efficacy and safety of GV1001 in patients with benign prostatic hyperplasia | Objectives: To determine and compare the efficacy and safety of GV1001 and 5 mg finasteride for benign prostatic hyperplasia (BPH) patients. Patients and methods: This randomized, active-controlled, multicenter, phase 3 clinical trial enrolled 423 patients aged >50 years with a prostate volume (PV) >30 mL. Patients were randomized into Group 1 (GV1001 0.56 mg + finasteride placebo), Group 2 (GV1001 1.12 mg + finasteride placebo), or Group 3 (GV1001 placebo +5 mg finasteride). The patients received the study drug during clinic visits every 2 weeks at weeks 0-22. Changes in the international prostate symptom score (IPSS), PV, maximum urinary flow rate (Qmax), prostate-specific antigen (PSA) level, residual urine volume, testosterone and dihydrotestosterone (DHT) levels, and international index of erectile function (IIEF) were assessed. Results: We included 408 (96.45%) patients (Group 1, n = 138; Group 2, n = 134; Group 3, n = 136) in full analysis set for primary efficacy evaluations. All groups showed significant decreases and increases in the IPSS and Qmax, respectively (Groups 1, 2, and 3, IPSS:-4.78 +/- 6.50,-4.99 +/- 6.66, and-5.51 +/- 6.42, respectively; P < 0.0001; Qmax: P = 0.0005, P = 0.0039, and P < 0.0001, respectively). PV reductions were observed in Groups 2 and 3 (-0.75 +/- 8.21 mL [P = 0.3280] and-2.47 +/- 7.92 mL [P = 0.0010], respectively). The PSA and testosterone levels of Group 3 significantly decreased and changed, respectively (-0.90 +/- 1.25 ng/mL, P < 0.0001 and P < 0.0001, respectively). No significant differences were observed in the residual urine volume. DHT significantly decreased in all groups (Groups 1, 2, and 3:-71.41 +/- 244.06 ng/mL [P = 0.0025],-73.84 +/- 249.26 ng/mL [P = 0.0019], and-106.60 +/- 178.29 ng/ mL [P < 0.0001], respectively). Only Group 3 exhibited a significantly decreased IIEF (-3.06 +/- 15.34; P = 0.0323). Acute urinary retention occurred in one patient in Group 2. No patients underwent prostate surgery or minimally invasive procedures during the study. Conclusions: GV1001 exhibited corresponding efficacy and tolerability, providing evidence of amelioration in urinary symptoms among patients with BPH in comparison to the use of 5 mg finasteride. (c) 2025 The Asian Pacific Prostate Society. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Shin, Teak Jun; Ha, Ji Yong; Kwon, Se Yun; Park, Dong Jin; Kim, Jang Hwan; Lee, Sung Won; Jeong, In Gab; Lee, Ji Youl; Yoo, Tag Keun; Kim, Tae Hyoung; Moon, Du Geon; Hong, Sung Kyu; Cho, Jin Seon; Moon, Hong Sang; Lee, Jeong Woo; Yun, Seok Joong; Jeon, Youn Soo; Park, Jong Gwan; Kang, Taek Won; Moon, Ki Hak; Park, Jae Shin; Hah, Yoon Soo; Kwon, Tae Gyun; Chung, Jae Wook; Il Chung, Jae; Ryu, Dong Soo; Park, Sung Woo; Lee, Kyung Seop | Keimyung Univ, Dongsan Hosp, Daegu, South Korea; Dongguk Univ, Gyeongju Hosp, Gyeongju, South Korea; Severance Hosp, Ilsan, South Korea; Seoul Samsung Med Ctr, Seoul, South Korea; Seoul Asan Med Ctr, Seoul, South Korea; Catholic Univ Korea, Seoul ST Mary Hosp, Seoul, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Daejeon, South Korea; Chung Ang Univ Hosp, Seoul, South Korea; Korea Univ, Guro Hosp, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Hallym Univ, Med Ctr, Chunchon, South Korea; Hanyang Univ, Med Ctr, Seoul, South Korea; Dongguk Univ, Med Ctr, Goyang, South Korea; Chungbuk Natl Univ Hosp, Cheongju, South Korea; Soonchunhyang Univ Hosp, Seoul, South Korea; Jeonbuk Natl Univ Hosp, Jeonju, South Korea; Chonnam Natl Univ Hosp, Gwangju, South Korea; Yeungnam Univ, Med Ctr, Gyongsan, South Korea; Daegu Catholic Univ, Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Changwon Samsung Med Ctr, Obstet & Gynecol, Chang Won, South Korea; Pusan Natl Univ, Yangsan Hosp, Busan, South Korea | Ha, Ji Yong/KSM-0577-2024; Hong, Sung/J-5722-2012; Yoo, Tag/M-8852-2019 | 55192758100; 57640139900; 35995613300; 59477156600; 55897977300; 55988988200; 16424885800; 57202074202; 9742586900; 57212837594; 14120066600; 24468238500; 35241941000; 7402662561; 59727430600; 16302421300; 7201888289; 59477411200; 36065936000; 59436197100; 12446166500; 54406906800; 15073765400; 35204798500; 57213670565; 59477288800; 57185889000; 35313516400 | ksleemd@dsmc.or.kr; | PROSTATE INTERNATIONAL | PROSTATE INT | 2287-8882 | 2287-903X | 13 | 2 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.6 | 31.2 | 0 | 2025-05-07 | 0 | 0 | Benign prostatic hyperplasia; Finasteride; International prostate symptom score; Prostate volume; Randomized controlled trial; GV10 01 | EPITHELIAL-MESENCHYMAL TRANSITION; SURGICAL-TREATMENT; ANDROGEN RECEPTOR; FINASTERIDE; DIHYDROTESTOSTERONE; COMPLICATIONS; MEN | Benign prostatic hyperplasia; Finasteride; GV1001; International prostate symptom score; Prostate volume; Randomized controlled trial | androstanolone; finasteride; placebo; prostate specific antigen; tertomotide; testosterone; aged; Article; connective tissue disease; controlled study; cyst; drug efficacy; drug safety; drug withdrawal; gastrointestinal disease; human; infection; infestation; inguinal hernia; International Index of Erectile Function; International Prostate Symptom Score; liver cell carcinoma; major clinical study; male; malignant neoplasm; multicenter study; musculoskeletal disease; neoplasm; neurologic disease; phase 3 clinical trial; polyp; postvoid residual urine volume; prostate hypertrophy; prostate volume; randomized controlled trial; urine flow rate; urine retention | English | 2025 | 2025-06 | 10.1016/j.prnil.2024.10.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | An area and power efficient ternary serial adder using phase composite ZnO stack channel FETs | Multi-valued logic is the subject of ongoing investigation owing to its potential to reduce the complexity of logic circuits and interconnect lengths, thereby reducing system power consumption. In this work, ternary stack channel field-effect transistors (SCFETs) are used as unit devices to realize multi-valued logic. The thickness of each ZnO layer in the SCFET is modulated to obtain the device parameters to control the intermediate-state range and saturation current. Using the experimental results, ternary circuits are modeled and simulated to demonstrate that the unique characteristics of SCFETs can be utilized in designing a ternary full adder. The designed ternary full adder requires only 12 devices (approximately 29% of the binary full adder device count). The ternary serial adder has a competitive power-delay product value of approximately 7 fJ at VDD = 1 V and an effective oxide thickness of 1 nm. These results indicate that SCFET-based ternary circuits are a promising alternative for extremely low-power applications. | Kim, Kiyung; Kim, Sunmean; Kim, So-Young; Lee, Yongsu; Lee, Hae-Won; Kang, Seokhyeong; Lee, Byoung Hun | Pohang Univ Sci & Technol, Dept Elect Engn, Cheongam Ro 77, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41556, South Korea | 57207404832; 57193135112; 59448030900; 57193347303; 57223255178; 35848454700; 57201966410 | bhlee1@postech.ac.kr; | NANOSCALE ADVANCES | NANOSCALE ADV | 2516-0230 | 7 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 4.6 | 31.2 | 0 | 2025-05-07 | 0 | 0 | MULTIPLE-VALUED LOGIC; CNTFET-BASED DESIGN; TRANSISTOR; GATES | Combinatorial circuits; High electron mobility transistors; Low power electronics; Many valued logics; Power field effect transistors; Area-Efficient; Field-effect transistor; Full adders; Multi-valued; Phase composites; Power efficient; Reducing systems; Serial adders; Ternary circuits; ZnO; Adders | English | 2025 | 2025-05-27 | 10.1039/d5na00045a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Skin rash in metastatic hormone sensitive prostate cancer patients treated with apalutamide: a retrospective multicenter study in Korea | Background: Skin rash is a common adverse event in patients with metastatic hormone-sensitive prostate cancer (mHSPC) treated with apalutamide. This study aims to investigate the incidence rate of skin rash and the predictive value of inflammation markers for skin rash in real-world Korean patients. Materials and Methods: We conducted a retrospective analysis of patients with prostate cancer (PCa) who received apalutamide across 18 institutions in Korea, with a follow-up period of at least three months. A total of 218 patients were evaluated. Results: Among the 214 patients analyzed, 78 (36.4%) developed a skin rash. The severity of the rash was classified as grade 1 (G1) in 27 patients (12.6%), grade 2 (G2) in 29 patients (13.5%), and grade 3 (G3) in 22 patients (10.3%). The median time to onset of any skin rash was 65.5 days (interquartile range, IQR 31.0-88.0). The monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation response index (SIRI) were significantly higher in the G2 plus G3 group compared to the no rash plus G1 group (p=0.006, p=0.013, respectively) before apalutamide treatment. After 3 months, platelet-to-lymphocyte ratio (PLR) and SIRI were significantly higher in the G2 plus G3 group compared to the no rash plus G1 group (p=0.010, p=0.025, respectively) | Kim, Won Tae; Han, Hyun Ho; Yun, Seok Joong; Yu, Seong Hyeon; Kang, Taek Won; Ha, Yun-Sok; Lee, Jun Nyung; Kwon, Tae Gyun; Kim, Byung Hoon; Seo, Won Ik; Lee, Chan Ho; Il Chung, Jae; Jo, Jung Ki; Ha, U-Syn; Lee, Ji Youl; Jeon, Hwang Gyun; Il Seo, Seong; Koo, Kyo Chul; Ha Chung, Byung; Kim, Jong Wook; Choi, Joongwon; Park, Jong Wook; Park, Hongzoo; Park, Sungchan; Kim, Soo Dong; Lee, Hak Min; Hong, Sung Kyu; Joung, Jae Young | Chungbuk Natl Univ, Coll Med, Chungbuk Natl Univ Hosp, Dept Urol, Cheongju, South Korea; Yonsei Univ, Urol Sci Inst, Dept Urol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Urol, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Urol, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Urol, Busan, South Korea; Hanyang Univ, Coll Med, Dept Urol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Urol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Urol, Seoul, South Korea; Korea Univ, Coll Med, Dept Urol, Guro Hosp, Seoul, South Korea; Joong Ang Univ, Gwangmyung Hosp, Dept Urol, Coll Med, Gwangmyung, South Korea; Korea Canc Ctr Hosp, Dept Urol, Seoul, South Korea; Kangwon Natl Univ, Sch Med, Dept Urol, Chunchon, South Korea; Univ Ulsan, Dept Urol, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea; Dong A Univ, Coll Med, Dept Urol, Busan, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Urol, Seongnam, South Korea; Natl Canc Ctr, Ctr Urol Canc, Goyang, South Korea | Kim, Jong Wook/HTP-6808-2023; Yu, Seong Hyeon/AEM-1724-2022; Choi, Joongwon/ABG-8559-2021; Hong, Sung/J-5722-2012 | 57203514393; 55158267400; 16302421300; 55745358000; 36065936000; 35487226400; 16301364600; 15073765400; 57203500751; 7006043190; 55855972900; 57213670565; 37060991000; 59716142200; 59716263000; 7201833627; 7202469835; 56568723500; 59133976600; 57192647677; 59039818600; 57196405297; 36101702400; 55677038800; 42961635600; 59528247200; 24468238500; 57222985702 | skhong@snubh.org; urojy@ncc.re.kr; | PROSTATE INTERNATIONAL | PROSTATE INT | 2287-8882 | 2287-903X | 13 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.6 | 31.2 | 0 | 2025-05-07 | 0 | 0 | Apalutamide; Prostatic neoplasms; Neoplasm metastasis | LYMPHOCYTE RATIO; NEUTROPHIL; PLATELET; MACROPHAGES; SURVIVAL | Apalutamide; Neoplasm metastasis; Prostatic neoplasms | apalutamide; aged; Article; cancer patient; controlled study; drug eruption; eosinophil count; follow up; human; incidence; Korea; lymphocyte count; major clinical study; male; metastatic castration sensitive prostate cancer; monocyte count; monocyte lymphocyte ratio; neutrophil count; neutrophil lymphocyte ratio; platelet lymphocyte ratio; predictive value; retrospective study; systemic inflammation response index | English | 2025 | 2025-03 | 10.1016/j.prnil.2024.10.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Thermal Conductivity in Side-Chain Liquid-Crystal Epoxy Polymers: Influence of Mesogen Structure | Side-chain liquid-crystal epoxy polymers (SCLCEPs) are valued for their unique properties, which combine LC side chains with epoxide-based polyether main chains for ordered molecular arrangements. They have high thermal conductivity and optical properties due to their low polydispersity and high crystallinity. Achieving optimal thermal conductivity in SCLCEPs involves addressing factors such as mesogen nature, polymer design, and alignment within the polymer structure. Balancing these factors enhances their suitability for heat dissipation in advanced materials. In this study, SCLCEPs with a polyethylene glycol backbone and laterally arranged mesogens are synthesized via anionic ring opening of mesogenic epoxides with unique LC phases. These monomers, which feature biphenyl mesogens attached to glycidyloxy ether and different alkyl chain lengths on the other side, is designed to facilitate mesogen self-assembly and interaction. The resulting polymers exhibited higher crystallinity and LC phases than the monomers. Notably, because of their LC nature, their thermal conductivity exceeds 0.48 Wm-1 K-1 and increases with shortened alkyl chain lengths, reaching 0.57 Wm-1 K-1. This research expands the applications of SCLCEPs in advanced fields requiring enhanced thermal properties. | Trinh, Thi En; Ku, Kyosun; Yeo, Hyeonuk | Kyungpook Natl Univ, Dept Sci Educ, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Water Ind, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Educ, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea | yeo, hyeonuk/G-7890-2017; Yeo, Hyeonuk/AHE-0397-2022 | 58092720700; 57219781815; 55324816500 | yeo@knu.ac.kr; | MACROMOLECULAR RAPID COMMUNICATIONS | MACROMOL RAPID COMM | 1022-1336 | 1521-3927 | 46 | 6 | SCIE | POLYMER SCIENCE | 2024 | 4.3 | 31.4 | 5.45 | 2025-05-07 | 2 | 2 | epoxide; liquid crystal; liquid crystalline polymer; mesogen; thermal conductivity | BEHAVIOR; POLYETHERS; POLYMERIZATION; OXIRANES | epoxide; liquid crystal; liquid crystalline polymer; mesogen; thermal conductivity | Epoxy Compounds; Epoxy Resins; Liquid Crystals; Molecular Structure; Polymers; Thermal Conductivity; Liquid crystals; Photonic band gap; Polyethylene glycols; Ring opening polymerization; Thermal conductivity of liquids; Thermal conductivity of solids; epoxide; epoxy resin; liquid crystal polymer; polymer; Crystalline polymers; Epoxide; Epoxy polymers; High crystallinity; Liquid crystalline; Liquid-crystals; Mesogens; Property; Side chain liquid crystals; Thermal; chemical structure; chemistry; liquid crystal; synthesis; thermal conductivity; Chain length | English | 2025 | 2025-04 | 10.1002/marc.202400762 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Aspartate aminotransferase-to-platelet ratio index outperforms Fibrosis-4 in 2843 Korean patients with metabolic dysfunction-associated steatotic liver disease | AimThe definition of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed. We aim to investigate the diagnostic efficacy of noninvasive fibrosis markers in predicting liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated fatty liver disease (MAFLD), and MASLD.MethodsThis retrospective study involved 2843 patients diagnosed with steatotic liver disease at six tertiary hospitals in South Korea. Liver fibrosis was assessed using vibration-controlled transient elastography, and various noninvasive markers, including the aspartate aminotransferase-to-platelet ratio index (APRI), Fibrosis-4 index (FIB-4), NAFLD fibrosis score (NFS), and serum Mac-2-binding protein glycosylation isomer were analyzed.ResultsAmong 1106 patients, 79.9% met criteria for NAFLD, MAFLD, and MASLD. The APRI had area under the receiver operating characteristic curve (AUC) values of 0.819, 0.821, and 0.818 for liver fibrosis >= F2, and 0.819, 0.824, and 0.884 for liver fibrosis >= F3, and 0.890, 0.884, and 0.889 for fibrosis >= F4 in NAFLD, MAFLD, and MASLD, respectively. The FIB-4 index showed AUC values of 0.776, 0.793, and 0.778 for fibrosis >= F2, 0.788, 0.814, and 0.79 for fibrosis >= F3, and 0.846, 0.859, and 0.856 for fibrosis >= F4. The APRI consistently had the highest AUC values, except in individuals older than 64 years for fibrosis >= F4.ConclusionsThe APRI was the most effective noninvasive fibrosis marker across NAFLD, MAFLD, and MASLD, particularly in age-stratified analyses. Further research is needed to establish standardized cut-off values and enhance the clinical utility of these markers in managing liver fibrosis. | Jang, Se Young; Yoon, Ki Tae; Cho, Young Youn; Jo, Hoon Gil; Baek, Yang Hyun; Moon, Sang Yi; Jo, Ae Jeong; Kweon, Young-Oh; Park, Soo Young; Lee, Yu Rim; Jun, Dae Won; Tak, Won Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ, Yangsan Hosp, Liver Ctr, Yangsan, Gyeongsangnamdo, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea; Wonkwang Univ, Coll Med & Hosp, Dept Internal Med, Div Gastroenterol, Iksan, Jeonlabukdo, South Korea; Dong A Univ Coll Med, Dept Internal Med, Busan, South Korea; Andong Natl Univ, Dept Informat Stat, Andong 36729, Gyeongsangbukdo, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Hanyang Inst Biosci & Biotechnol, Seoul, South Korea | Se Young, Jang/MTD-4362-2025; Jun, Dae Won/O-4529-2017 | 57202881977; 14820137300; 55850994200; 57217410042; 15844799800; 56393618900; 57190185428; 7004694832; 57191674344; 57194094753; 57226004346; 7004074582 | noshin@hanyang.ac.kr; wytak@knu.ac.kr; | HEPATOLOGY RESEARCH | HEPATOL RES | 1386-6346 | 1872-034X | 55 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.4 | 31.6 | 0 | 2025-05-07 | 0 | 0 | AST-to-platelet ratio index; FIB-4; metabolic dysfunction-associated steatotic liver disease; noninvasive fibrosis marker | MAC-2 BINDING-PROTEIN; SIMPLE NONINVASIVE INDEX; PREDICT; VARIABILITY; STAGE; NAFLD | AST-to-platelet ratio index; FIB-4; metabolic dysfunction-associated steatotic liver disease; noninvasive fibrosis marker | alanine aminotransferase; albumin; aspartate aminotransferase; gamma glutamyltransferase; glucose; hemoglobin A1c; high density lipoprotein cholesterol; triacylglycerol; adult; alcohol consumption; Article; aspartate aminotransferase to platelet ratio index; blood cell count; body height; body mass; body weight; computer assisted tomography; controlled study; diagnostic test accuracy study; echography; female; Fibrosis-4 Index; human; hypertension; hypertriglyceridemia; isomer; lipid fingerprinting; liver fibrosis; major clinical study; male; metabolic fatty liver; middle aged; nonalcoholic fatty liver; obesity; platelet count; predictive value; protein glycosylation; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; transient elastography; waist circumference | English | 2025 | 2025-04 | 10.1111/hepr.14143 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Head-to-Head Comparison of Long-Term HCC Risk of Antivirals-Treated Versus Untreated Low-Level Viremia in HBV-Compensated Cirrhosis | BackgroundAmong patients with hepatitis B virus (HBV)-infected compensated cirrhosis and low-level viremia, there are limited data for comparative outcomes between those treated with oral nucleos(t)ide analogs versus those not. We conducted a large, multi-ethnic, multi-center study to examine the impact of antiviral treatment (AVT) on long-term hepatocellular carcinoma (HCC) risk for compensated cirrhosis and low-level viremia.MethodsPatients with compensated cirrhosis and low-level viremia (serum HBV-DNA 20-2000 IU/mL) at baseline or before AVT were screened for eligibility from 19 hospitals in South Korea, Singapore, and Japan. The primary outcome was HCC development, compared between those receiving AVT versus those untreated throughout follow-up.ResultsAmong 848 patients (mean age 55.7 years and 66.9% male), AVT (n = 233) was associated with significantly lower annual HCC incidence compared to non-AVT (n = 615); 1.72/100 versus 2.99/100 person-years (PY), respectively (p = 0.033). Multivariable Cox-regression analyses determined that AVT was associated with significantly lower HCC risk, compared to non-AVT (adjusted HR [HR] 0.514, 95% confidence interval [CI] 0.271-0.976; p = 0.042). In a landmark analysis, HCC incidence was similar between two groups until 18 months, but after this landmark, the treated group had the significantly lower HCC risk compared to untreated group (p = 0.012). Furthermore, propensity score-matching analysis consistently showed that AVT was associated with significantly lower HCC risk, compared to non-AVT; the annual HCC incidence of 1.45/100 PYs versus 2.73/100 PY, respectively (p = 0.043).ConclusionsPatients with compensated cirrhosis and low-level viremia may benefit from long-term AVT, highlighting appropriate amendment of reimbursement guidelines. | Tamaki, Nobuharu; Huang, Daniel Q.; Lee, Hyung Woong; Park, Soo Young; Lee, Yu Rim; Sinn, Dong Hyun; Lim, Tae Seop; Marusawa, Hiroyuki; Lim, Seng Gee; Ochi, Hironori; Kondo, Masahiko; Uchida, Yasushi; Kobashi, Haruhiko; Furuta, Koichiro; Kurosaki, Masayuki; Kim, Beom Kyung | Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore; Natl Univ Singapore Hosp, Div Gastroenterol & Hepatol, Singapore, Singapore; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Osaka Red Cross Hosp, Dept Gastroenterol & Hepatol, Osaka, Japan; Matsuyama Red Cross Hosp, Ctr Liver Biliary Pancreat Dis, Matsuyama, Ehime, Japan; Japanese Red Cross Otsu Hosp, Dept Otolaryngol, Otsu, Japan; Matsue Red Cross Hosp, Dept Gastroenterol, Matsue, Japan; Japanese Red Cross Okayama Hosp, Dept Gastroenterol, Okayama, Japan; Masuda Red Cross Hosp, Dept Gastroenterol, Masuda, Japan | Sinn, Dong/L-3701-2019; Sinn, Dong Hyun/O-5941-2014; LIM, Seng/AAD-9040-2020 | 36197581200; 57211508470; 59758809400; 59280453500; 59712240600; 23493891100; 59670725700; 6701365971; 59668962400; 57212330499; 36882270800; 7401607120; 7003583870; 59758924000; 35308923600; 59656009200 | beomkkim@yuhs.ac; | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | J GASTROEN HEPATOL | 0815-9319 | 1440-1746 | 40 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.4 | 31.6 | 0 | 2025-05-07 | 0 | 0 | antiviral treatment; compensated cirrhosis; hepatitis B virus; hepatocellular carcinoma; low-level viremia | HEPATITIS-B; DNA | antiviral treatment; compensated cirrhosis; hepatitis B virus; hepatocellular carcinoma; low-level viremia | Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Japan; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Republic of Korea; Risk Factors; Time Factors; Viremia; alanine aminotransferase; antivirus agent; aspartate aminotransferase; hepatitis B(e) antigen; antivirus agent; virus DNA; adult; antiviral therapy; Article; cancer incidence; cancer risk; cohort analysis; comparative study; compensated liver cirrhosis; confidence interval; controlled study; cumulative incidence; female; Fibrosis-4 Index; follow up; hospital; human; Kaplan Meier method; knowledge gap; liver cell carcinoma; major clinical study; male; middle aged; multicenter study; propensity score; proportional hazards model; retrospective study; South Korea; viremia; aged; blood; chronic hepatitis B; clinical trial; comparative study; complication; drug therapy; epidemiology; etiology; genetics; Hepatitis B virus; incidence; Japan; liver cirrhosis; liver tumor; prevention and control; risk factor; time factor; virology | English | 2025 | 2025-06 | 10.1111/jgh.16986 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-Time Self-Supervised Ultrasound Image Enhancement Using Test-Time Adaptation for Sophisticated Rotator Cuff Tear Diagnosis | Medical ultrasound imaging is a key diagnostic tool across various fields, with computer-aided diagnosis systems benefiting from advances in deep learning. However, its lower resolution and artifacts pose challenges, particularly for non-specialists. The simultaneous acquisition of degraded and high-quality images is infeasible, limiting supervised learning approaches. Additionally, self-supervised and zero-shot methods require extensive processing time, conflicting with the real-time demands of ultrasound imaging. Therefore, to address the aforementioned issues, we propose real-time ultrasound image enhancement via a self-supervised learning technique and a test-time adaptation for sophisticated rotational cuff tear diagnosis. The proposed approach learns from other domain image datasets and performs self-supervised learning on an ultrasound image during inference for enhancement. Our approach not only demonstrated superior ultrasound image enhancement performance compared to other state-of-the-art methods but also achieved an 18% improvement in the RCT segmentation performance. | Lee, Haeyun; Lee, Kyungsu; Yoon, Jong Pil; Kim, Jihun; Kim, Jun-Young | Korea Univ Technol & Educ, Sch Comp Sci & Engn, Cheonan 31253, South Korea; Jeonbuk Natl Univ, Dept Comp Sci & Artificial Intelligence, Jeonju 54896, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Daegu 41566, South Korea; Kangnam Univ, Div Elect & Semicond Engn, Elect Engn, Yongin 16979, South Korea; Catholic Univ Daegu, Sch Med, Dept Orthoped Surg, Daegu 42472, South Korea | Kim, Jihun/ABY-7662-2022 | 57204044244; 57215845124; 36098548400; 57189691294; 57201935381 | haeyun@koreatech.ac.kr; ksl@jbnu.ac.kr; altjp1@gmail.com; jihunk@kangnam.ac.kr; dr.junyoung@gmail.com; | IEEE SIGNAL PROCESSING LETTERS | IEEE SIGNAL PROC LET | 1070-9908 | 1558-2361 | 32 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 3.9 | 31.6 | 0 | 2025-05-07 | 0 | 0 | Ultrasonic imaging; Image restoration; Training; Real-time systems; Self-supervised learning; Biomedical imaging; Image enhancement; Superresolution; Image resolution; Medical diagnostic imaging; Ultrasound image; image enhancement; test time adaptation; rotator cuff tear | image enhancement; rotator cuff tear; test time adaptation; Ultrasound image | Image segmentation; Medical imaging; Ultrasonic testing; Ultrasonography; Computer aided diagnosis systems; Diagnostics tools; Medical ultrasound imaging; Real- time; Rotator cuff; Rotator cuff tear; Test time; Test time adaptation; Ultrasound image enhancements; Ultrasound images; Self-supervised learning | English | 2025 | 2025 | 10.1109/lsp.2025.3557754 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | STSPhys: Enhanced Remote Heart Rate Measurement With Spatial-Temporal SwiftFormer | Estimating heart activities and physiological signals from facial video without any contact, known as remote photoplethysmography and remote heart rate estimation, holds significant potential for numerous applications. In this letter, we present a novel approach for remote heart rate measurement leveraging a Spatial-Temporal SwiftFormer architecture (STSPhys). Our model addresses the limitations of existing methods that rely heavily on 3D CNNs or 3D visual transformers, which often suffer from increased parameters and potential instability during training. By integrating both spatial and temporal information from facial video data, STSPhys achieves robust and accurate heart rate estimation. Additionally, we introduce a hybrid loss function that integrates constraints from both the time and frequency domains, further enhancing the model's accuracy. Experimental results demonstrate that STSPhys significantly outperforms existing state-of-the-art methods on intra-dataset and cross-dataset tests, achieving superior performance with fewer parameters and lower computational complexity. | Kim, Hyunduk; Lee, Sang-Heon; Sohn, Myoung-Kyu; Kim, Jungkwang; Park, Hyeyoung | Daegu Gyeongbuk Inst Sci & Technol, Div Automot Technol, Daegu, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 37224, South Korea | hyunduk00@dgist.ac.kr; pobbylee@dgist.ac.kr; smk@dgist.ac.kr; kjk1208@dgist.ac.kr; hypark@knu.ac.kr; | IEEE SIGNAL PROCESSING LETTERS | IEEE SIGNAL PROC LET | 1070-9908 | 1558-2361 | 32 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 3.9 | 31.6 | 0 | Convolution; Heart rate; Accuracy; Estimation; Frequency-domain analysis; Visualization; Testing; Skin; Image color analysis; Feature extraction; RPPG; rHR; spatial-temporal visual trasnformer | English | 2025 | 2025 | 10.1109/lsp.2024.3522854 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | ○ | Article | BTX-A inhibited trigeminal neuralgia by blocking the NLRP3 pathway in rats | Few studies have examined the mechanisms underlying the development of trigeminal neuralgia involving the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3). The purpose of this experiment was to investigate the role of NLRP3 in the antinociceptive effects of botulinum toxin type A (BTX-A) in trigeminal neuralgia. We used a trigeminal neuralgia animal model induced by injecting 1-acyl-2-lyso-sn-glycero-3-phosphate (LPA) into the trigeminal nerve root of rats. Rats treated with LPA showed a significant increase in the expression of NLRP3 in the trigeminal ganglion 9 days after LPA injection. Furthermore, the levels of interleukin (IL)-1 beta, IL-18, and tumor necrosis factor (TNF)-alpha increased on postoperative day 9. Subcutaneous administration of BTX-A (3 U/kg) in the vibrissa pad resulted in a significant attenuation of mechanical allodynia, and the antiallodynic effects lasted for 7 days. The upregulated NLRP3 expression in the trigeminal ganglion was suppressed 2 days after the injection of BTX-A. Moreover, the BTX-A injection significantly reduced the concentrations of IL-1 beta, IL-18, and TNF-alpha in the trigeminal ganglion. Intraganglionic injection of an NLRP3 inhibitor blocked mechanical allodynia and attenuated the upregulated cytokine concentrations in the LPA-treated rats. These results indicate that BTX-A induces its antinociceptive effects in the LPA-induced trigeminal neuralgia animal model by attenuating the NLRP3-cytokine pathway in the trigeminal ganglion. | Park, Se-Kyung; Son, Jo-Young; Kim, Yu-Mi; Ju, Jin-Sook; Ahn, Dong-Kuk | Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Craniofacial Nerve Bone Network Res Ctr, Daegu, South Korea | 59736766400; 57201998311; 57816812300; 7202751199; 59882170600 | dkahn@knu.ac.kr; | BRAIN RESEARCH BULLETIN | BRAIN RES BULL | 0361-9230 | 1873-2747 | 225 | SCIE | NEUROSCIENCES | 2024 | 3.7 | 31.7 | 0 | 2025-05-07 | 0 | 0 | Botulinum toxin; Trigeminal neuralgia; Inflammasome; Cytokines; Trigeminal nerve root | TOXIN TYPE-A; NEUROPATHIC PAIN; NERVE CONSTRICTION; INFRAORBITAL NERVE; SENSORY NEURONS; COMPRESSION; ALLODYNIA; HYPERALGESIA; ACTIVATION; MECHANISM | Botulinum toxin; Cytokines; Inflammasome; Trigeminal nerve root; Trigeminal neuralgia | Animals; Botulinum Toxins, Type A; Disease Models, Animal; Hyperalgesia; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Trigeminal Ganglion; Trigeminal Neuralgia; acetylcholine; botulax; botulinum toxin A; cryopyrin; cytokine; glycerophosphate; inflammasome; interleukin 18; interleukin 1beta; ketamine; tumor necrosis factor; xylazine; botulinum toxin A; cryopyrin; Nlrp3 protein, rat; animal experiment; animal model; animal tissue; Article; brain; controlled study; enzyme linked immunosorbent assay; injection; male; mechanical allodynia; nonhuman; rat; repeated drug dose; treatment outcome; trigeminal nerve; trigeminus ganglion; trigeminus neuralgia; vibrissa; Western blotting; animal; disease model; drug effect; drug therapy; hyperalgesia; metabolism; signal transduction; Sprague Dawley rat; trigeminus neuralgia | English | 2025 | 2025-06-01 | 10.1016/j.brainresbull.2025.111344 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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