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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Review ⓘ Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions ⓘ Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions. © 2025 The Royal Society of Chemistry. ⓘ Nguyen, Kianna; Che, Quang Tuan; Nguyen, Quoc Huynh; Gwon, Kihak; Gonzalez Suarez, Alan; Stybayeva, Gulnaz; Huebert, Robert; Peterson, Quinn; Revzin, Alexander ⓘ Medical Scientist Training Program, Mayo Clinic Alix School of Medicine & Mayo Clinic Graduate School of Biomedical Sciences, 200 1st St SW, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Department of Biofiber and Materials Science Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, South Korea; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States; Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 1st St SW, Rochester, MN, United States ⓘ ⓘ 57221325637; 59954505600; 59953954900; 50461594700; 57189660429; 24722171600; 6603059162; 14030555700; 7003422366 ⓘ revzin.alexander@mayo.edu; ⓘ Biomaterials Science ⓘ BIOMATER SCI-UK ⓘ 2047-4830 2047-4849 SCIE MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 5.7 30.0 ⓘ 0 ⓘ ⓘ ⓘ Cytology; Disease control; Stem cells; 'current; Cellular therapy; Derived products; Liver cells; Microencapsulation technology; Pancreatic cells; Pluripotent stem cells; Stem-cell; Technological solution; Versatile tools; B lymphocyte; cell differentiation; cell encapsulation; fetus; human; human cell; liver cell; microencapsulation; pancreas; pluripotent stem cell; review; stem cell; Microencapsulation ⓘ English Article in press 2025 10.1039/d5bm00696a ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Morphological and cytogenetic evaluation of Phalaenopsis cultivars ⓘ The genus Phalaenopsis (family Orchidaceae) comprises approximately 66 species and is a popular choice for potted ornamental plants. Recent years have witnessed increased commercial demand for a wide range of Phalaenopsis hybrids with various flower colors, shapes, fragrances, and increased tolerance to biotic and abiotic stress. Interspecific and intergeneric hybridization between different sections or subgenera has been widely used to develop cultivars with novel traits. As a consequence of these hybridizations, polyploidy is frequently observed in Phalaenopsis, as indicated by a wide range of chromosome numbers. Considering the dearth of information on Phalaenopsis species and cultivars used in breeding, morphological, cytogenetic, and genomic studies are essential for providing plant scientists and breeders with critical knowledge. In this study, the morphological characteristics, and chromosomal compositions of 35 Phalaenopsis standard and novelty cultivars were evaluated. All examined Phalaenopsis cultivars possessed unique phenotypic characteristics, and cytogenetic analysis revealed that most cultivars were aneuploids with hyper- and hypoploid chromosome numbers. All standard cultivars exhibited small, uniformly sized chromosomes, whereas certain novelty cultivars possessed asymmetrical small, medium, and large chromosomes. The results of this study provide valuable insights for breeders aiming to devise efficient Phalaenopsis breeding programs. Clinical trial number Not applicable. © The Author(s), under exclusive licence to Korean Society for Horticultural Science 2025. ⓘ Sevilleno, Samantha Serafin; Cabahug-Braza, Raisa Aone; An, Hye Ryun; Lim, Ki-Byung; Park, Hye Wan; Hwang, Yoon-Jung ⓘ Plant Genetics and Breeding Institute, Sahmyook University, Seoul, 01795, South Korea, Department of Convergence Science, Sahmyook University, Seoul, 01795, South Korea; Plant Genetics and Breeding Institute, Sahmyook University, Seoul, 01795, South Korea; Floriculture Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Wanju, 55365, South Korea; Department of Horticultural Science, Kyungpook National University, Daegu, 41566, South Korea; Department of Convergence Science, Sahmyook University, Seoul, 01795, South Korea; Plant Genetics and Breeding Institute, Sahmyook University, Seoul, 01795, South Korea, Department of Convergence Science, Sahmyook University, Seoul, 01795, South Korea ⓘ ⓘ 57212649168; 58453620000; 55324789600; 7403175915; 59118673900; 50061210800 ⓘ hyj@syu.ac.kr; ⓘ Horticulture Environment and Biotechnology ⓘ HORTIC ENVIRON BIOTE ⓘ 2211-3452 2211-3460 SCIE HORTICULTURE ⓘ 2024 2.4 30.0 0 2025-05-07 ⓘ 0 ⓘ ⓘ Aneuploidy; Breeding; Cytogenetics; Morphology; Orchid; Phalaenopsis ⓘ ⓘ English Article in press 2025 10.1007/s13580-025-00704-z ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Undoped Cs3Cu2I5 crystal - Candidate for dark matter searches: Temperature-dependent scintillation and luminescence ⓘ Intrinsic scintillators offer significant advantages for advanced applications due to the uniform distribution of their luminescence centers. In this research, we investigated the luminescence and scintillation characteristics of undoped Cs3Cu2I5 crystals at room temperature and cryogenic conditions, comparing their potential for dark matter detection with that of CsI crystals. Like CsI, Cs3Cu2I5 is non-hygroscopic and exhibits a higher scintillation light yield. Typically, the light yield of intrinsic scintillators, such as undoped CsI and NaI, tends to increase at cryogenic temperatures, and we anticipate a similar trend for Cs3Cu2I5. To explore this further, we analyzed the scintillation properties of Cs3Cu2I5 down to 10 K under 662 keV gamma-ray excitation. Remarkably, the absolute light yield of Cs3Cu2I5 reached 150 ph/keV at 662 keV, significantly exceeding that of CsI under similar conditions. Additional studies employing photoluminescence and thermally stimulated luminescence across temperatures from 300 K to 10 K suggested that the enhanced scintillation yield at lower temperatures may be linked to self- activators' behavior in a free state. Simulations of the temperature-dependent energy transfer processes support this finding, highlighting the potential for improved light yields at cryogenic temperatures. These results confirm that undoped Cs3Cu2I5 crystals are promising for dark matter searches utilizing cryogenic methods. ⓘ Luan, N. T.; Kim, H. J.; Lee, J.; Khan, A.; Jegal, J.; Ton, N. D.; Truc, L. T. ⓘ Kyungpook Natl Univ, Ctr High Energy Phys, Daegu, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Najran Univ, Fac Arts & Sci, Dept Phys, Najran, Saudi Arabia; Najran Univ, Adv Mat & Nano Res Ctr ANBRC, Najran, Saudi Arabia; Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul, South Korea ⓘ Khan, Arshad/ABB-1566-2021 ⓘ 57210576969; 58483690400; 36835827400; 56017063700; 57192238874; 57966935300; 58303266600 ⓘ hongjoo@knu.ac.kr; ⓘ JOURNAL OF LUMINESCENCE ⓘ J LUMIN ⓘ 0022-2313 1872-7883 281 SCIE OPTICS ⓘ 2024 3.6 30.0 0 2025-05-07 ⓘ 0 0 Scintillation; Luminescence; Low temperature; Scintillation mechanism; Modeling; Light yield; Dark matter searches ⓘ LIGHT YIELD; NON-PROPORTIONALITY; ENERGY RESOLUTION; PURE NAI; SCATTERING; RECOMBINATION; TRANSPORT; CSI ⓘ Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub>; Dark matter searches; Light yield; Low temperature; Luminescence; Modeling; Scintillation; Scintillation mechanism ⓘ Atomic emission spectroscopy; Cadmium alloys; Cesium iodide; Dark Matter; Hadrons; Laser beams; Layered semiconductors; Luminescence of inorganic solids; Photons; Scintillation; Scintillation counters; Advanced applications; Cryogenic temperatures; Dark matter searches; Light yield; Lows-temperatures; Luminescence centers; Modeling; Scintillation mechanisms; Temperature dependent; Uniform distribution; Gamma rays ⓘ English 2025 2025-06 10.1016/j.jlumin.2025.121143 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Association between calcium channel blocker use and the risk of interstitial lung disease and idiopathic pulmonary fibrosis: A longitudinal cohort study ⓘ Introduction: Ca2+ signaling in fibroblasts would be one of the important mediators of lung fibrosis. This study investigated the relationship between calcium channel blocker usage and the risk of developing interstitial lung disease and idiopathic pulmonary fibrosis. Material and methods: This cohort study used data from the Korean National Health Screening Cohort spanned from January 1, 2004, to December 31, 2015. The study included 394,142 participants. CCB usage, as a time- dependent variable assessed every two years, was categorized by medication status (ever-users and never- users) and further divided into five groups based on cumulative defined daily dose: = 547.5. Incidence rates of ILD and IPF among CCB users compared to never-users, analyzed using time-dependent Cox regression models. Results: The incidence rates were 27.7 per 100,000 person-years for ILD and 15.0 per 100,000 person-years for IPF among never-users, compared to 19.5 per 100,000 person-years for ILD and 13.9 per 100,000 person-years for IPF among ever-users. The adjusted hazard ratios (aHRs) were 0.68 [95 % confidence interval (CI), 0.55-0.83] for ILD and 0.69 (95 % CI, 0.54-0.88) for IPF. Increasing categories of CCB usage were significantly associated with a lower risk of ILD [aHRs: 1.23 (95 % CI, 0.97-1.56), 1.20 (0.85-1.71), 0.49 (0.30-0.81), and 0.27(0.19-0.39)] and IPF [aHRs: 1.21 (95 % confidence interval, 0.89-1.64), 1.45 (0.96-2.20), 0.83 (0.52-1.33), and 0.25 (0.16-0.38)], compared to never-users. Conclusions: This study found that individuals using CCBs had a significantly lower risk of interstitial lung disease and idiopathic pulmonary fibrosis compared to never-users in a dose-response manner. ⓘ Jang, Hye Jin; Seong, Yu Min; Jeong, Jihyeon; Huh, Jin-Young; Kim, Jin-Ho; Kim, Kyung Hoon; Park, Joo Hun; Choi, Won-Il ⓘ Inha Univ, Inha Univ Hosp, Dept Internal Med, Div Pulmonol,Sch Med, Incheon, South Korea; Hanyang Univ, Myongji Hosp, Div Pulmonol,Coll Med, Dept Internal Med, Ansan, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Gwangmyeong, South Korea; Hanyang Univ, Myongji Hosp, Dept Internal Med, Div Cardiol,Coll Med, Ansan, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Div Pulm & Crit Care Med, Dept Internal Med,Coll Med, Incheon, South Korea; Ajou Univ, Sch Med, Dept Pulm & Crit Care Med, Suwon, South Korea ⓘ Kim, Kyung Hoon/IXD-3892-2023; Jang, Hye Jin/IZE-4223-2023 ⓘ 57222352277; 57214877952; 57209972988; 57388732500; 56813149200; 57666814100; 8598117800; 7402516121 ⓘ wichoi7572@hanyang.ac.kr; ⓘ RESPIRATORY MEDICINE ⓘ RESP MED ⓘ 0954-6111 1532-3064 237 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS;RESPIRATORY SYSTEM ⓘ 2024 3.1 30.1 0 2025-05-07 ⓘ 0 0 Calcium channel blocker; Idiopathic pulmonary fibrosis; Incidence; Interstitial lung disease ⓘ FIBROBLASTS; INHIBITION; PDGF ⓘ Calcium channel blocker; Idiopathic pulmonary fibrosis; Incidence; Interstitial lung disease ⓘ Adult; Aged; Calcium Channel Blockers; Cohort Studies; Female; Humans; Idiopathic Pulmonary Fibrosis; Incidence; Longitudinal Studies; Lung Diseases, Interstitial; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Risk; Risk Factors; amlodipine; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; diltiazem; diuretic agent; felodipine; hydroxymethylglutaryl coenzyme A reductase inhibitor; nicardipine; nifedipine; nimodipine; nisoldipine; verapamil; calcium channel blocking agent; adult; aged; Article; cardiovascular risk; cohort analysis; controlled study; disease course; drug efficacy; female; fibrosing alveolitis; human; incidence; interstitial lung disease; longitudinal study; major clinical study; male; middle aged; retrospective study; epidemiology; fibrosing alveolitis; interstitial lung disease; proportional hazards model; risk; risk factor; South Korea ⓘ English 2025 2025-02 10.1016/j.rmed.2025.107939 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Comparing Heterogenous Phenotypes of Chronic Obstructive Pulmonary Disease: Network Analysis and Penalized Generalized Linear Model ⓘ Background and Objective: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, with chronic bronchitis (CB) and emphysema phenotypes. The aim of our study was to compare the distinct patterns of correlation networks for respiratory symptoms and predictors of future exacerbations of different COPD phenotypes. Methods: CB and emphysema were identified using a questionnaire and computed tomography images, respectively, and also included patients with preserved ratio impaired spirometry (PRISm). We constructed separate correlation networks for each subgroup using Spearman correlation coefficients. Predictors of future exacerbations were selected via least absolute shrinkage and selection operation regression analyses in multivariable analysis. Results: Among the 3436 patients, 2232 were non-CB, 1131 were CB, 1116 were emphysema, and 73 were PRISm groups. The forced expiratory volume in one second (FEV1) and respiratory symptoms worsened in the following order: PRISm, non-CB, emphysema, and CB groups. During the 1-year follow-up, 17.3%, 21.3%, and 18.9% of patients in the non-CB, CB, and emphysema groups, respectively, experienced exacerbation. Each group showed a distinct correlation pattern between demographic characteristics, comorbidities, pulmonary function, blood biomarkers, respiratory symptoms, and exercise capacity. Across all groups, lower FEV1 (%), higher white blood cell count, higher erythrocyte sedimentation rate, and worse Saint George's Respiratory Questionnaire symptom and total scores were identified as common risk factors for future exacerbations. However, each group showed distinct predictors for future exacerbations. Conclusion: The correlation network patterns and predictors of future exacerbations varied significantly depending on the COPD phenotype. Further research is required to understand the heterogeneous COPD pathophysiology and facilitate personalized medicine. Plain Language Summary: COPD has various subtypes, including chronic bronchitis, emphysema, and PRISm phenotypes. This study compared symptom patterns and predictors of future exacerbation in these groups. We analyzed data from over 3400 patients and observed that lung function and symptoms worsened in the following order: PRISm, non-chronic bronchitis, emphysema, and chronic bronchitis. Each group showed distinct patterns of relationships between demographics, lung function, biomarkers, and respiratory symptoms. Although some risk factors overlapped, each group had its own predictors for future exacerbation. Understanding these differences among subtypes could lead to better personalized treatments for COPD patients. ⓘ Koo, Hyeon-Kyoung; Chung, Sung Jun; Park, Dongil; Kim, Ho Cheol; Seo, Hyewon; Kim, Hyun Jung; Yoon, Hyoung Kyu; Rhee, Chin Kook; Ha Yoo, Kwang; Kim, Deog Kyeom ⓘ Inje Univ, Coll Med, Div Pulm & Crit Care Med, Dept Internal Med,Ilsan Paik Hosp, Goyang, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Pulmonol, Deajeon, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Changwon Hosp, Sch Med, Dept Internal Med, Jinju, South Korea; Kyungpook Natl Univ, Sch Med, Div Pulm & Crit Care Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med,Yeouido St Marys Hosp, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Seoul, South Korea; Konkuk Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sch Med, Seoul, South Korea; Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea ⓘ Rhee, Chin Kook/P-8885-2018 ⓘ 36622978100; 57216275821; 59656900300; 57196215317; 59903847100; 59717470500; 59727194500; 55612130200; 7202592740; 14060371000 ⓘ kimdkmd@snu.ac.kr; ⓘ INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ⓘ INT J CHRONIC OBSTR ⓘ 1178-2005 20 SCIE RESPIRATORY SYSTEM ⓘ 2024 3.1 30.1 N/A ⓘ 0 0 COPD; exacerbation; heterogeneous; network analysis ⓘ COPD; EXACERBATION; ASSOCIATION; PERFORMANCE; SELECTION ⓘ COPD; exacerbation; heterogeneous; network analysis ⓘ Aged; Bronchitis, Chronic; Disease Progression; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Linear Models; Lung; Male; Middle Aged; Phenotype; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Retrospective Studies; Risk Factors; Spirometry; Surveys and Questionnaires; Time Factors; Tomography, X-Ray Computed; aged; allergic rhinitis; area under the curve; Article; asthma; atopic dermatitis; body mass; bronchiectasis; chronic bronchitis; chronic obstructive lung disease; cohort analysis; computer assisted tomography; controlled study; COPD assessment test; data collection method; diabetes mellitus; diagnostic test accuracy study; diffusing capacity for carbon monoxide; disease exacerbation; disease severity; emphysema; eosinophil; erythrocyte sedimentation rate; female; follow up; forced expiratory volume; forced vital capacity; heart disease; hospitalization; human; hypertension; least absolute shrinkage and selection operator; lung function; lung function test; machine learning; major clinical study; male; Modified Medical Research Council Dyspnea Scale; mortality; multivariate analysis; network analysis; oxygen saturation; pathophysiology; penalized generalized linear model; phenotype; prediction; predictive value; quality of life; questionnaire; receiver operating characteristic; risk factor; sensitivity and specificity; six minute walk test; smoking; spirometry; St. George Respiratory Questionnaire; statistical model; tuberculosis; chronic bronchitis; comparative study; diagnosis; diagnostic imaging; exercise tolerance; lung; lung emphysema; middle aged; phenotype; retrospective study; statistical model; time factor; x-ray computed tomography ⓘ English 2025 2025 10.2147/copd.s496199 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Cardiovascular Etiologies and Risk Factors of Survival Outcomes After Resuscitation for Out-of-Hospital Cardiac Arrest: Data From the KoCARC Registry ⓘ Background and Objectives: The outcomes and characteristics of out-of-hospital cardiac arrest (OHCA) vary across geographic regions. The etiologies and prognoses of OHCA in Asian populations remain less established. This study aimed to investigate the etiologies and clinical characteristics of patients successfully resuscitated after OHCA and to identify predictors of survival outcomes. Methods: Data were extracted from a South Korean multicenter prospective registry of OHCA that included 64 tertiary hospitals from 2015 to 2018 (n=7,577). The primary outcome was in-hospital mortality, and the secondary outcome was a Cerebral Performance Category (CPC) score of grade 1 at discharge. Results: Of the 7,577 patients, 2,066 achieved return of spontaneous circulation (ROSC) and were hospitalized. A total of 915 (44.2%) presented with ventricular arrhythmia (VA) as their initial rhythm or on admission. The leading cause was obstructive coronary artery disease (n=413; 20.0%). Sudden unexplained death syndrome (SUDS) accounted for 67.5% of survivors and was significantly less common in patients with VA (82.7% vs. 48.3%, p<0.001). VA was an independent predictor of in-hospital mortality (adjusted hazard ratio, 0.774; 95% confidence interval [CI], 0.633-0.946; p=0.012) and the grade-1 CPC score at discharge (odds ratio, 2.822; 95% CI, 1.909-4.172; p<0.001). Other predictors of in-hospital mortality included age, diabetes mellitus, witnessed cardiac arrest, ROSC on arrival, total arrest time, alertness on admission, extracorporeal membrane oxygenation use, targeted temperature management, and coronary reperfusion. Conclusions: SUDS was common in patients with ROSC after OHCA. VA was independently associated with favorable survival outcomes at discharge. Prompt clinical intervention may improve clinical outcomes in patients with OHCA, particularly those with VA. Copyright © 2025. The Korean Society of Cardiology. ⓘ Jeong, Joo Hee; Min, Kyongjin; Choi, Jong-Il; Kim, Su Jin; Roh, Seung-Young; Han, Kap Su; Song, Juhyun; Lee, Sung Woo; Kim, Young-Hoon; Han, Sang Kuk; Choi, Phil Cho; Lee, Young Hwan; Park, Sang O.; Lee, Jong Seok; Jeong, Ki Young; Choi, Sung Hyuk; Yoon, Young Hoon; Sim, Min Seob; Lee, Gun Tak; Kim, Youn Jung; Shin, Jong Whan; Lee, Hui Jai; Park, Keun Hong; Kim, Hahn Bom; Park, Yoo Seok; Choi, Arom; Kong, Tae Young; Hwang, Hyuna; Cho, Youngsuk; Kang, Gu Hyun; Jang, Yong Soo; Oh, Jae Hoon; Lee, Jun Cheol; Park, Sung Wook; Yang, Wook Tae; Ryu, Hyun Wook; Ahn, Jae Yun; Yang, Hyuk Jun; Woo, Jae-Hyug; Yun, Sung Hyun; Kim, Chong Sun; Kim, Sun Pyo; Lee, Jin Woong; Jeong, Wonjoon; Park, Sung Soo; Lee, Jae Kwang; Ahn, Ryeok; Choi, Wook Jin; Rhee, Bang Shill; Jo, You Hwan; Park, Sung Min; Kim, In Byung; Ahn, Ki Ok; Ahn, Se Joong; Lee, Seung Cheol; Lee, Sang Hun; Lee, Kyeong Min; Kim, Young Sik; Park, Jin Sik; Park, Myung Hee; Wi, Dai Han; Bae, Jin Kun; Lee, Yong Hee; Ha, Sang Ook; Yang, Won Seok; Park, Ju Ok; Park, Hang A.; Cha, Kyoung Chul; Jung, Woo Jin; Ohk, Taek Geun; Shin, Myoung Cheol; Eob, An Mu; Park, Kyung Sook; Kim, Sang Chul; Park, Gwan Jin; Choi, Han Joo; Kim, Yong Oh; Jung, Tae Oh; Yoon, Jae Chol; Park, Young Tae; Lee, Ju Taek; Jeong, Jin Hee; Lee, Sang Bong; Kim, Won; Moon, Yi Sang; Song, Sung Wook; Ko, Seo Young; Kwon, Joon-Myoung; Kang, Eui Hyuk; Jin, Sang Chan; Kim, Tae-Kwon; Kim, Chang Sun; Shin, Hyun Goo; Choi, Dong Sun; Ha, Chul Min; Ko, Jai Woog; Hwang, Yun Jeong; Chung, Sung Phil; Song, Kyung Jun; Na, Sang Hoon; Cho, Gyu Chong; Hwang, Seung Sik; Hwang, Sung Oh; Shin, Sang Do; Yang, Hyuk Jun; Park, Jeong Ho; Park, Jong Hak; Kim, Won Young; Jung, Jin Hee; Kim, Ji Hoon; Choi, Yeongho; Choi, Seulki; Lee, Se Jin; Joo, Hye Jee ⓘ Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea; Division of Cardiology, Department of Internal Medicine, Incheon Sejong Hospital, Incheon, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea; Department of Emergency Medicine, Korea University Medicine, Korea University College of Medicine, Seoul, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea; Department of Emergency Medicine, Korea University Medicine, Korea University College of Medicine, Seoul, South Korea; Department of Emergency Medicine, Korea University Medicine, Korea University College of Medicine, Seoul, South Korea; Department of Emergency Medicine, Korea University Medicine, Korea University College of Medicine, Seoul, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea; Kangbuk Samsung Medical Center, South Korea; Kangbuk Samsung Medical Center, South Korea; Konkuk University Medical Center, South Korea; Konkuk University Medical Center, South Korea; Kyung Hee University Hospital, South Korea; Kyung Hee University Hospital, South Korea; Korea University Guro Hospital, South Korea; Korea University Guro Hospital, South Korea; Samsung Medical Center, South Korea; Samsung Medical Center, South Korea; Asan Medical Center, South Korea; SMG-SNU Boramae Medical Center, South Korea; SMG-SNU Boramae Medical Center, South Korea; Seoul Medical Center, South Korea; Seoul Medical Center, South Korea; Yonsei University, Severance Hospital, South Korea; Yonsei University, Severance Hospital, South Korea; Yonsei University, Gangnam Severance Hospital, South Korea; Yonsei University, Gangnam Severance Hospital, South Korea; Hallym University, Kangdong Sacred Heart Hospital, South Korea; Hallym University, Kangnam Sacred Heart Hospital, South Korea; Hallym University, Kangnam Sacred Heart Hospital, South Korea; Hanyang University, Seoul Hospital, South Korea; Hanyang University, Seoul Hospital, South Korea; Pusan National University Hospital, South Korea; Pusan National University Hospital, South Korea; Kyungpook National University Hospital, South Korea; Kyungpook National University Hospital, South Korea; Gachon University Gil Medical Center, South Korea; Catholic Kwandong University, International St. Mary's Hospital, South Korea; Catholic Kwandong University, International St. Mary's Hospital, South Korea; Chosun University Hospital, South Korea; Chungnam National University Hospital, South Korea; Chungnam National University Hospital, South Korea; Konyang University Hospital, South Korea; Konyang University Hospital, South Korea; Ulsan University Hospital, South Korea; Ulsan University Hospital, South Korea; Ajou University Hospital, South Korea; Seoul National University, Bundang Hospital, South Korea; Seoul National University, Bundang Hospital, South Korea; Myongji Hospital, South Korea; Myongji Hospital, South Korea; Korea University, Ansan Hospital, South Korea; Dongguk University, Ilsan Hospital, South Korea; Dongguk University, Ilsan Hospital, South Korea; Dongguk University, Ilsan Hospital, South Korea; Bundang Jesaeng Hospital, South Korea; Sejong Hospital, South Korea; Sejong Hospital, South Korea; Wonkwang University, Sanbon Hospital, South Korea; Cha University Bundang Medical Center, South Korea; Cha University Bundang Medical Center, South Korea; Hallym University, Pyeongchon Sacred Heart Hospital, South Korea; Hallym University, Pyeongchon Sacred Heart Hospital, South Korea; Hallym University, Dongtan Sacred Heart Hospital, South Korea; Hallym University, Dongtan Sacred Heart Hospital, South Korea; Wonju Severance Christian Hospital, South Korea; Wonju Severance Christian Hospital, South Korea; Kangwon National University Hospital, South Korea; Kangwon National University Hospital, South Korea; Hallym University, Chuncheon Sacred Heart Hospital, South Korea; Hallym University, Chuncheon Sacred Heart Hospital, South Korea; Chungbuk National University Hospital, South Korea; Chungbuk National University Hospital, South Korea; Dankook University Hospital, South Korea; Dankook University Hospital, South Korea; Chonbuk National University Hospital, South Korea; Chonbuk National University Hospital, South Korea; Dongguk University, Gyeongju Hospital, South Korea; Dongguk University, Gyeongju Hospital, South Korea; Gyeongsang National University Hospital, South Korea; Gyeongsang National University Hospital, South Korea; Cheju Halla General Hospital, South Korea; Cheju Halla General Hospital, South Korea; Jeju National University Hospital, South Korea; Jeju National University Hospital, South Korea; Mediplex Sejong Hospital, South Korea; Mediplex Sejong Hospital, South Korea; Keimyung University Dongsan Medical Center, South Korea; Keimyung University Dongsan Medical Center, South Korea; Hanyang University Guri Hospital, South Korea; Hanyang University Guri Hospital, South Korea; Uijeongbu Eulji Medical Center, Eulji University, South Korea; Hanil General Hospital, South Korea; Yongin Severance Christian Hospital, South Korea; Yongin Severance Christian Hospital, South Korea; Yonsei University, Gangnam Severance Hospital, South Korea; SMG-SNU Boramae Medical Center, South Korea; Seoul National University Hospital, South Korea; Hallym University, Kangdong Sacred Heart Hospital, South Korea; Seoul National University, South Korea; Wonju Severance Christian Hospital, South Korea; Seoul National University Hospital, South Korea; Gachon University Gil Medical Center, South Korea, University Gil Hospital, South Korea; Seoul National University Hospital, South Korea; Korea University, Ansan Hospital, South Korea; Asan Medical Center, South Korea; SMG-SNU Boramae Medical Center, South Korea; Yonsei University, Severance Hospital, South Korea; Seoul National University, Bundang Hospital, South Korea; Seoul National University Hospital, South Korea; Seoul National University Hospital, South Korea; Seoul National University Hospital, South Korea ⓘ ⓘ 57547817300; 57221758244; 59215852700; 57196044127; 35783384000; 56660189900; 57191371872; 55716352800; 56713962900; 58598285500; 35147471400; 59751375900; 53464106200; 56812788200; 57195055265; 15759087700; 7402126765; 26645185500; 57200128091; 35280110200; 57214228643; 37665247900; 57221912396; 59774968400; 18134244600; 57203834959; 57190857780; 59751963000; 59480865600; 57208187938; 36468655500; 53878311700; 57093128600; 59731672000; 57941781100; 59751674000; 59750917900; 59616017400; 59654921500; 57221914773; 59751673900; 56049988200; 59333447300; 59617975400; 57221916210; 57219387841; 37664458300; 59585465000; 57226145316; 25822597600; 59750917800; 57220758869; 23975564100; 57219389954; 58376382200; 57192279003; 59750917700; 57221919703; 59076488000; 59774735000; 59617975500; 59773573800; 59773554700; 59751817100; 59751220200; 59732641400; 57051645300; 59618471600; 59657709600; 59774479600; 59773786700; 57221906944; 59751673800; 59509375900; 57193389046; 57198427159; 59751817000; 57221906570; 59464488300; 59773786800; 59774022200; 57203640937; 59774257600; 55661654200; 59751220100; 54407727200; 57200967790; 59616017300; 57221904895; 57205700670; 57226863363; 55520496300; 57193806427; 59751520700; 59751520600; 59751070200; 59750917400; 57293073100; 59750917300; 8692979300; 59615523100; 14066254900; 59616990900; 59615523000; 59654921400; 57222635486; 57196407523; 57246488900; 57199984314; 55760887500; 57560397800; 57223209597; 59774257700; 59773327500 ⓘ jongilchoi@korea.ac.kr; icarusksj@gmail.com; ⓘ Korean Circulation Journal ⓘ KOREAN CIRC J ⓘ 1738-5520 1738-5555 55 4 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS ⓘ 2024 3.1 30.2 N/A ⓘ 1 ⓘ ⓘ Out-of-hospital cardiac arrest; Sudden unexplained death syndrome; Tachycardia, ventricular; Ventricular fibrillation ⓘ adult; alertness; Article; cardiovascular risk factor; cohort analysis; controlled study; coronary angiography; coronary artery spasm; coronary reperfusion; diabetes mellitus; electrocardiography; extracorporeal oxygenation; female; heart failure; heart ventricle arrhythmia; hospital admission; hospital mortality; human; hypertrophic cardiomyopathy; in-hospital mortality; induced hypothermia; inherited arrhythmia syndrome; major clinical study; male; obstructive coronary artery disease; out of hospital cardiac arrest; outcome assessment; percutaneous coronary intervention; prospective study; resuscitation; return of spontaneous circulation; South Korea; ST segment elevation myocardial infarction; sudden arrhythmic death syndrome; survival; tertiary care center; transthoracic echocardiography ⓘ English Final 2025 10.4070/kcj.2024.0243 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Comparison of Thick Biolimus A9-Eluting Stent and Thin Zotarolimus-Eluting Stent in Multi-Vessel Percutaneous Coronary Intervention ⓘ Background and Objectives: There are limited randomized studies on patients undergoing multi-vessel percutaneous coronary intervention (PCI) comparing the outcomes between stent thickness and polymer types. To compare the clinical outcomes of thick biodegradable polymer-based biolimus A9-eluting stents (BESs) and thin durable polymer-based zotarolimus-eluting stents (ZESs) in patients undergoing multi-vessel PCI. Methods: A total of 936 patients who underwent multi-vessel coronary artery stenting were randomly assigned to the BES (n=472) or ZES (n=464) groups. The primary endpoint was 2-year major adverse cardiac events (MACEs), a composite of all-cause death, myocardial infarction (MI), and any revascularization at the 2-year follow-up. Results: Fifty-two (11.2%) of 472 patients in BES group and 50 (10.9%) of the 464 patients in ZES group met the 2-year primary endpoint of MACE (hazard ratio, 1.00; 90% confidence interval, 0.72, 1.38; p=0.994). All-cause death (BES vs. ZES: 2.8% vs. 2.7%, p=0.758), MI (2.1% vs. 2.6%, p=0.483), and repeat revascularization (6.7% vs. 6.9%, p=0.876) were not significantly different between the 2 groups. Although there was no significant outcome difference in any subgroup analysis, the technical failure rate leading to the use of other stents was higher in BES than in ZES (3.2% vs. 0.9%, p=0.023). Conclusions: In patients who underwent multi-vessel PCI, BES and ZES showed comparable 2-year clinical outcomes. However, BES was not established to demonstrate non-inferiority to ZES in terms of the incidence of the primary endpoint at the 2-year. The technical success rate of the index PCI with the assigned stent was higher for thinner ZES. ⓘ Lee, Cheol Hyun; Lee, Hee Jeong; Chung, Tae-Wan; Lee, Seonhwa; Hwang, Jongmin; Kim, In-Cheol; Cho, Yun-Kyeong; Yoon, Hyuck-Jun; Hur, Seung-Ho; Kim, Jin Young; Kim, Yun Seok; Jang, Woo Sung; Lee, Jang Hoon; Kim, Woong; Lee, Jin Bae; Hong, Young Joon; Heo, Jung Ho; Lee, Bong-Ryeol; Doh, Joon-Hyung; Shin, Eun-Seok; Koo, Bon-Kwon; Nam, Chang-Wook ⓘ Keimyung Univ, Dongsan Hosp, Dept Internal Med, Div Cardiol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Cardiol, Daegu, South Korea; Yeungnam Univ, Med Ctr, Dept Internal Med, Div Cardiol, Daegu, South Korea; Daegu Catholic Univ, Med Ctr, Dept Cardiol, Daegu, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Cardiol, Gwangju, South Korea; Kosin Univ, Gospel Hosp, Coll Med, Div Cardiol,Dept Internal Med, Busan, South Korea; Daegu Fatima Hosp, Dept Internal Med, Div Cardiol, Daegu, South Korea; Inje Univ, Ilsan Paik Hosp, Coll Med, Div Cardiol,Dept Internal Med, Goyang, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Cardiol, Ulsan, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Cardiovasc Ctr, Seoul, South Korea ⓘ Lee, Seon Hwa/AEH-0404-2022; Koo, Bon-Kwon/J-5374-2012; Yoon, HJ/IYJ-7484-2023 ⓘ ⓘ ncwcv@dsmc.or.kr; ⓘ KOREAN CIRCULATION JOURNAL ⓘ KOREAN CIRC J ⓘ 1738-5520 1738-5555 55 5 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS ⓘ 2024 3.1 30.2 ⓘ 1 Drug-eluting stent; Percutaneous coronary intervention; Polymer ⓘ BARE-METAL STENTS; DURABLE POLYMER; BIODEGRADABLE POLYMER; 3-YEAR OUTCOMES; BYPASS-SURGERY; END-POINTS; BIOFLOW V; FOLLOW-UP; ULTRATHIN; TRIALS ⓘ ⓘ ⓘ English 2025 2025-05 10.4070/kcj.2024.0101 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Engineering Saccharomyces boulardii for cell surface display of heterologous protein ⓘ Saccharomyces boulardii and Saccharomyces cerevisiae share over 99 % genetic similarity yet exhibit distinct metabolic traits. While the cell surface display system of S. cerevisiae is well-documented, the equivalent system in S. boulardii has yet to be fully characterized. This study investigates the cell surface display system of S. boulardii for the expression of a heterologous protein using different anchor proteins. Six strains expressing the enhanced green fluorescent protein (Egfp) and an anchor protein as a fusion protein were constructed to visualize the cell surface display system. Then a heterologous endo-inulinase protein was expressed with selected anchor proteins through fluorescence intensity comparison. Analysis by fluorescence microscopy revealed that the anchor protein Sed1 exhibited the highest fluorescence intensity. Furthermore, expressed selected anchor proteins and heterologous protein, endo-inulinase, the engineered strain could degrade and consume almost inulin in 72 h. Through endo-inulinase expression, we confirmed that not only Egfp but also heterologous protein is well expressed, and we successfully built an S. boulardii cell surface display system. ⓘ Shin, Jamin; Lee, Gayoung; Chi, Won-Jae; Park, Sujeong; Jin, Yong-Su; Kim, Soo Rin ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Natl Inst Biol Resources, Species Divers Res Div, Incheon 22689, South Korea; Univ Illinois Champaign Urbana, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea ⓘ Kim, Soo Rin/X-2192-2019; Jin, Yong-Su/L-4530-2013 ⓘ 57347431000; 59419949100; 7006817223; 57218916250; 57204009076; 36659584200 ⓘ sjmim0220@gmail.com; kyy28203579@gmail.com; wjchi76@korea.kr; tya198@naver.com; ysjin@illinois.edu; soorinkim@knu.ac.kr; ⓘ JOURNAL OF BIOTECHNOLOGY ⓘ J BIOTECHNOL ⓘ 0168-1656 1873-4863 397 SCIE BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 3.9 30.2 3.66 2025-05-07 ⓘ 1 1 Saccharomyces boulardii; Cell surface display system; Anchor protein; Endo-inulinase ⓘ PICHIA-PASTORIS; TRANSFORMATION; CEREVISIAE; EXPRESSION; SECRETION; PATHWAY ⓘ Anchor protein; Cell surface display system; Endo-inulinase; Saccharomyces boulardii ⓘ Cell Surface Display Techniques; Fungal Proteins; Glycoside Hydrolases; Green Fluorescent Proteins; Recombinant Fusion Proteins; Saccharomyces boulardii; Cell engineering; Cell membranes; Fluorescence microscopy; agglutinin; CRISPR associated endonuclease Cas9; enhanced green fluorescent protein; glycosylphosphatidylinositol anchored protein; peptides and proteins; protein aga2; protein cwp1; protein cwp2; protein endo inulinase; protein pir1; protein sed1; protein tir1; unclassified drug; enhanced green fluorescent protein; fungal protein; fusion protein; glycosidase; green fluorescent protein; inulinase; Anchor proteins; Cell surface display system; Cell surface displays; Endo-inulinase; Enhanced green fluorescent protein; Heterologous proteins; Inulinase; Saccharomyces; Saccharomyces boulardii; Surface display system; Article; cell surface display; confocal microscopy; controlled study; CRISPR-CAS9 system; Escherichia coli; fluorescence intensity; fluorescence microscopy; fungal strain; high performance liquid chromatography; nonhuman; protein expression; quantitative analysis; Saccharomyces boulardii; cell surface display; genetics; metabolism; procedures; Display devices ⓘ English 2025 2025-01 10.1016/j.jbiotec.2024.11.013 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Enhanced Capacitive Performance of Microwave-Driven CNTs on Carbonized Cigarette Filter Waste for Sustainable Energy Storage ⓘ Microplastic pollution represents a significant global environmental issue, with cigarette filters being a major contributor due to their slow biodegradation. To address this issue while creating valuable materials, we developed a novel approach to synthesize nitrogen-doped carbon nanotubes on carbonized cigarette filter powder (NCNT@cCFP) using a microwave irradiation and nickel-catalyzed process. The successful incorporation of nitrogen (similar to 6.6 at.%) and the enhanced graphitic structure create a hierarchical conductive network with abundant active sites for electrochemical reactions. The resulting NCNT@cCFP electrode exhibits a specific capacitance of 452 F/g at 1 A/g in a three-electrode configuration. The integrated hierarchical structure facilitates efficient electron transport and ion diffusion, leading to excellent rate capability (91.6% at 10 A/g) and cycling stability (96.5% retention after 5000 cycles). Furthermore, a symmetric supercapacitor device demonstrates promising energy storage capability with a maximum energy density of 14.0 Wh/kg at 483.1 W/kg, while maintaining 10.4 Wh/kg at a high power density of 4419.1 W/kg. This synergistic waste recycling strategy combined with microwave-driven synthesis offers a sustainable pathway for developing high-performance energy storage materials. ⓘ Choi, Young Joong; Lee, Damin; Kwon, Se-Hun; Kim, Kwang Ho ⓘ Pusan Natl Univ, Sch Mat Sci & Engn, Busan 46241, South Korea; Kyungpook Natl Univ, Reg Leading Res Ctr Smart Energy Syst, Daegu 41566, South Korea; Pusan Natl Univ, Global Frontier R&D Ctr Hybrid Interface Mat, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea ⓘ Kim, Hee-Je/O-3501-2019 ⓘ 57209841706; 57194601076; 26433618200; 57199439961 ⓘ yjchoi0782@pusan.ac.kr; damin91@knu.ac.kr; sehun@pusan.ac.kr; kwhokim@pusan.ac.kr; ⓘ NANOMATERIALS ⓘ NANOMATERIALS-BASEL ⓘ 2079-4991 15 4 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED ⓘ 2024 4.3 30.2 0 2025-05-07 ⓘ 0 0 cigarette filter waste; nitrogen-doped carbon nanotubes; microwave synthesis; sustainable electrode materials; supercapacitors ⓘ NANOTUBES; GRAPHENE; ELECTRODES; CELLULOSE ⓘ cigarette filter waste; microwave synthesis; nitrogen-doped carbon nanotubes; supercapacitors; sustainable electrode materials ⓘ ⓘ English 2025 2025-02 10.3390/nano15040257 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Surface Modification, Toxicity, and Applications of Carbon Dots to Cancer Theranosis: A Review ⓘ Cancer remains one of the leading causes of death worldwide, prompting extensive research into novel theranostic (combined word of diagnostic and therapeutic) strategies. Nanomedicine has emerged as a potential breakthrough in cancer theranosis, overcoming limitations of conventional approaches. Among such approaches, carbon dots (CDs) with a size smaller than 10 nm have garnered significant attention for their potential use in cancer theranosis, owing to their low toxicity, good water solubility, easy synthesis, facile surface modification, and unique optical and photothermal and photodynamic properties. Researchers have demonstrated that surface functionalization of CDs with diverse hydrophilic groups can be easily achieved by choosing proper carbon precursors in synthesis, and further surface modification of CDs with cancer-targeting ligands, photosensitizers, anticancer drugs, and genes can also be easily achieved using various methods, thereby establishing a versatile approach for cancer theranosis. This review described the various surface modification methods of CDs, in vitro and in vivo toxicity of CDs, and various cancer theranostic methods such as drug delivery, photodynamic therapy, photothermal therapy, gene therapy, sonodynamic therapy, and gas therapy. Therefore, CDs can serve as various mono and combined theranostic modalities, offering us new methods for cancer theranosis. ⓘ Tegafaw, Tirusew; Mulugeta, Endale; Zhao, Dejun; Liu, Ying; Chen, Xiaoran; Baek, Ahrum; Kim, Jihyun; Chang, Yongmin; Lee, Gang Ho ⓘ Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Taegu 41944, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Chem Educ, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu 41944, South Korea ⓘ Beza, Endale/D-6211-2017 ⓘ 55983618600; 57199654704; 57222567792; 57221731093; 59938916200; 57194601711; 56954528100; 7501840633; 7404851841 ⓘ tirukorea@gmail.com; endexindex05@gmail.com; djzhao.chem@gmail.com; ly1124161@gmail.com; tsukiyovo@gmail.com; baxun@naver.com; jkim23@knu.ac.kr; ychang@knu.ac.kr; ghlee@mail.knu.ac.kr; ⓘ NANOMATERIALS ⓘ NANOMATERIALS-BASEL ⓘ 2079-4991 15 11 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED ⓘ 2024 4.3 30.2 N/A ⓘ 0 0 carbon dot; surface modification; toxicity; cancer; theranosis ⓘ BLOOD-BRAIN-BARRIER; PHOTODYNAMIC THERAPY; IN-VITRO; QUANTUM DOTS; FOLATE-RECEPTOR; DOXORUBICIN DELIVERY; GOLD NANOPARTICLES; OPTICAL-PROPERTIES; GREEN SYNTHESIS; DRUG-DELIVERY ⓘ cancer; carbon dot; surface modification; theranosis; toxicity ⓘ ⓘ English 2025 2025-05-22 10.3390/nano15110781 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review ⓘ Carbon dots (CDs) are metal-free carbon-based nanoparticles. They possess excellent photoluminescent properties, various physical properties, good chemical stability, high water solubility, high biocompatibility, and tunable surface functionalities, suitable for biomedical applications. Their properties are subject to synthetic conditions such as pH, reaction time, temperature, precursor, and solvent. Until now, a large number of articles on the synthesis and biomedical applications of CDs using their photoluminescent properties have been reported. However, their research on magnetic properties and especially, diamagnetic chemical exchange saturation transfer (diaCEST) in magnetic resonance imaging (MRI) is very poor. The diaCEST MRI contrast agents are based on exchangeable protons of materials with bulk water protons and thus, different from conventional MRI contrast agents, which are based on enhancements of proton spin relaxations of bulk water and tissue. In this review, various syntheses, characterizations, magnetic properties, and potential applications of CDs as diaCEST MRI contrast agents are reviewed. Finally, future perspectives of CDs as the next-generation diaCEST MRI contrast agents are discussed. ⓘ Mulugeta, Endale; Tegafaw, Tirusew; Liu, Ying; Zhao, Dejun; Baek, Ahrum; Kim, Jihyun; Chang, Yongmin; Lee, Gang Ho ⓘ Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41944, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Chem Educ, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41405, South Korea ⓘ Mulugeta (PhD), Associate Professor of Organic Chemistry, Endale/D-6211-2017; Beza, Endale/D-6211-2017 ⓘ 57199654704; 55983618600; 57221731093; 57222567792; 57194601711; 56954528100; 7501840633; 7404851841 ⓘ endexindex05@gmail.com; tirukorea@gmail.com; ly1124161@gmail.com; djzhao.chem@gmail.com; baxun@naver.com; jkim23@knu.ac.kr; ychang@knu.ac.kr; ghlee@mail.knu.ac.kr; ⓘ NANOMATERIALS ⓘ NANOMATERIALS-BASEL ⓘ 2079-4991 15 7 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED ⓘ 2024 4.3 30.2 0 2025-05-07 ⓘ 0 0 carbon dot; synthesis; characterization; magnetic properties; diaCEST; MRI contrast agent ⓘ QUANTUM DOTS; HYDROTHERMAL SYNTHESIS; GREEN SYNTHESIS; NANOPARTICLES; LUMINESCENT; NANODOTS; CEST; FLUORESCENCE; GENERATION; COMPLEXES ⓘ carbon dot; characterization; diaCEST; magnetic properties; MRI contrast agent; synthesis ⓘ ⓘ English 2025 2025-04-02 10.3390/nano15070542 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Electrochemical Corrosion Performance of Anodic TiO2 Nanotubes Synthesized from Glycerol-NH4F Stirred Electrolytes ⓘ Titanium oxide (TiO2) nanotubes produced on titanium (Ti) alloys by electrochemical anodic synthesis are used in biomedical and energy applications. Synthesis of these nanotubes involves fluoride ions, which travel in the electrolyte and reach the anodic Ti. Stirring of the electrolyte pushes the fluoride ions to move toward the anode and participate in oxidation. In this research work, anodic TiO2 was produced on Ti using 0.5 wt.% NH4F containing glycerol electrolyte (100 ml) for 20 and 30 V with the electrolyte being stirred by a magnetic pellet. Oxidation was done for 0.5 and 1 h at 20 V and 30 V using stirred and unstirred electrolyte conditions. The oxides produced from this method were amorphous (as synthesized) in all these conditions and became crystalline after the annealing process. This research showed that the nanotube length (minimum 600 and maximum 2300 nm) increased with electrolyte stirring, applied voltage, and oxidation time. The electrolyte stirring retained the tubular structure and provided rib-structured nanotubes for both the potential conditions. This study showed that oxidation for 1 h at 30 V in the unstirred condition produced nanotubes with excellent corrosion resistance in simulated body fluid (SBF). ⓘ Ramaswamy, Narayanan; Panigrahi, Mrutyunjay; Sivaprakash, Vetrivel; Ansari, M. N. M.; Kwon, Tae-Yub ⓘ Vellore Inst Technol, Sch Mech Engn, Chennai 600127, Tamil Nadu, India; Sathyabama Inst Sci & Technol, Sch Mech, Chennai 600119, Tamil Nadu, India; Univ Tenaga Nas, Inst Power Engn, Kajang 43000, Selangor, Malaysia; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Samduk Dong 700412, Daegu, South Korea ⓘ Ramaswamy, Narayanan/ABI-6187-2020; Vetrivel, Shivaprakash/AAY-7224-2021; Panigrahi, Mrutyunjay/AAB-3113-2020 ⓘ 7202724072; 36775104000; 57208314855; 55489853600; 7202206084 ⓘ mrutyunjayjapan@gmail.com; ⓘ JOM ⓘ JOM-US ⓘ 1047-4838 1543-1851 77 6 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;MINERALOGY;MINING & MINERAL PROCESSING ⓘ 2024 2.3 30.6 0 2025-06-11 ⓘ 0 0 ⓘ TITANIUM-OXIDE NANOTUBES; SURFACE MODIFICATION; ANODIZATION; FABRICATION; MORPHOLOGY; IMPLANTS; BEHAVIOR; GROWTH; BONE; CRYSTALLINITY ⓘ ⓘ Anodic oxidation; Corrosion resistant alloys; Nanotubes; Oxidation resistance; Titanium dioxide; Anodic synthesis; Biomedical applications; Condition; Corrosion performance; Electrochemicals; Fluoride ion; Synthesised; TiO 2 nanotube; Titanium (alloys); Titanium oxide TiO; Electrochemical corrosion ⓘ English 2025 2025-06 10.1007/s11837-025-07388-x ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Mechanistic pathways and optimization of salinity-tolerant antibiotic degradation catalyzed by Gracilaria verrucosa biochar ⓘ Tetracycline (TC), a commonly found antibiotic, poses ecological risks when present in aquatic environments. A low-cost activated biochar was developed from Gracilaria verrucosa (GBVC) via one-step pyrolysis (800 degrees C) and utilized to activate peroxydisulfate (PDS) for TC degradation. Under optimized conditions, GVBC800 achieved 100 % of TC degradation (TC =10 mg L1, GVBC800 =100 mg L1, PDS =1.25 mM, pH 5.0), with adaptability across a wide range of pH (3.0-11.0). TC degradation involved radical (center dot OH and SO4 center dot) and non-radical (1O2) pathways, as well as electron transfer, facilitated by pyridinic N, thiophene sulfur (S 2p3/2), and structural defects in GVBC800. In saline water, nearly 100 % TC removal was achieved using 2.5 mM of PDS and 200 mg L-1 of GVBC800. Degradation pathways were proposed and TC mineralization was evaluated, highlighting the efficacy of the GVBC800/PDS system for TC degradation in challenging environmental conditions ⓘ Bae, Soohyun; Al Masud, Md Abdullah; Shin, Won Sik ⓘ Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Univ Alabama, Dept Civil Construct & Environm Engn, Tuscaloosa, AL 35487 USA ⓘ Masud, Md Abdullah Al/JEF-1055-2023 ⓘ 58979083100; 57542255300; 23019870800 ⓘ wshin@knu.ac.kr; ⓘ CHEMICAL ENGINEERING SCIENCE ⓘ CHEM ENG SCI ⓘ 0009-2509 1873-4405 309 SCIE ENGINEERING, CHEMICAL ⓘ 2024 4.3 30.6 0 2025-05-07 ⓘ 1 1 Seaweed biochar; Peroxydisulfate; Tetracycline; Degradation mechanisms; Saline wate ⓘ ENTEROMORPHA ⓘ Degradation mechanisms; Peroxydisulfate; Saline water; Seaweed biochar; Tetracycline ⓘ Antibiotic degradation; Biochar; Degradation mechanism; Gracilaria; Mechanistic pathways; Optimisations; Peroxydisulfate; Salinity tolerant; Seaweed biochar; Tetracycline ⓘ English 2025 2025-05-01 10.1016/j.ces.2025.121455 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Assessment of Free Energies From Electrostatic Embedding Density Functional Tight Binding-Based/Molecular Mechanics in Periodic Boundary Conditions ⓘ Electrostatic embedding quantum mechanics/molecular mechanics (QM/MM) methods in periodic boundary conditions (PBC) can successfully describe the condensed phase reactivity of a fragment treated at the QM level with an atomistic description of an electrostatic environment treated at the MM level. The computational cost of ab initio QM methods limits the phase space sampling, thus affecting statistical quantities like free energies. Here, we describe the implementation of a PBC-adapted QM/MM model based on the semi-empirical density-functional based tight-binding (DFTB) method within the GAMESS-US quantum package interfaced with Tinker. Further, we take advantage of the free energy methods provided by a newly developed interface with the PLUMED plugin. The versatility of the implementation is illustrated by the prediction of the free energy profile for three different families of reactions in solution. Overall, using the DFTB/MM, it has been possible to obtain results that are at least in a qualitatively agreement with respect to the experimental data or high-level ab initio simulations. ⓘ Bonfrate, Simone; Park, Woojin; Trejo-Zamora, Dulce; Ferre, Nicolas; Choi, Cheol Ho; Huix-Rotllant, Miquel ⓘ Aix Marseille Univ, CNRS, ICR, Marseille, France; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Univ Toulouse III Paul Sabatier, Toulouse, France ⓘ Huix-Rotllant, Miquel/J-3291-2016; Huix-Rotllant, Miquel/S-8914-2019; Bonfrate, Simone/LSI-6399-2024; Ferré, Nicolas/K-8228-2012 ⓘ 57971754300; 57223952329; 59412751400; 7003305008; 59760728500; 25634188900 ⓘ cchoi@knu.ac.kr; miquel.huix-rotllant@cnrs.fr; ⓘ JOURNAL OF COMPUTATIONAL CHEMISTRY ⓘ J COMPUT CHEM ⓘ 0192-8651 1096-987X 46 11 SCIE CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.8 30.8 0 2025-05-07 ⓘ 0 0 DFTB; enzymatic catalysis; free energy; peptidyl-propyl cis-trans isomerase; QM/MM ⓘ CIS-TRANS-ISOMERIZATION; SCC-DFTB METHOD; QM/MM CALCULATIONS; IMPLEMENTATION; PARAMETRIZATION; SIMULATIONS; CATALYSIS; BENCHMARK; PEPTIDES; DYNAMICS ⓘ DFTB; enzymatic catalysis; free energy; peptidyl-propyl cis-trans isomerase; QM/MM ⓘ Phase space methods; cis trans isomerase; propane; Cis-trans; Density functional based tight bindings; Density-functional tight-binding; Embeddings; Energy; Enzymatic catalysis; Isomerases; Peptidyl-propyl cis-trans isomerase; Periodic boundary conditions; Quantum mechanics/molecular mechanics; ab initio calculation; article; biocatalysis; cheminformatics; controlled study; density; energy; molecular mechanics; pharmaceutics; prediction; quantum mechanics; simulation; Density functional theory ⓘ English 2025 2025-04-30 10.1002/jcc.70107 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2022 ⓘ Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2022, with international comparisons. Materials and Methods Cancer incidence, survival, and prevalence rates were calculated using the Korea National Cancer Incidence Database (1999-2022), with survival follow-up until December 31, 2023. Mortality data obtained from Statistics Korea, while international comparisons were based on GLOBOCAN data. Results In 2022, 282,047 newly diagnosed cancer cases (age-standardized rate [ASR], 287.0 per 100,000) and 83,378 deaths from cancer (ASR, 65.7 per 100,000) were reported. The proportion of localized-stage cancers increased from 45.6% in 2005 to 50.9% in 2022. Stomach, colorectal, and breast cancer showed increased localized-stage diagnoses by 18.1, 18.5, and 9.9 percentage points, respectively. Compared to 2001-2005, the 5-year relative survival (2018-2022) increased by 20.4 percentage points for stomach cancer, 7.6 for colorectal cancer, and 5.6 for breast cancer. Korea had the lowest cancer mortality among countries with similar incidence rates and the lowest mortality-to-incidence (M/I) ratios for these cancers. The 5-year relative survival (2018-2022) was 72.9%, contributing to over 2.59 million prevalent cases in 2022. Conclusion Since the launch of the National Cancer Screening Program in 2002, early detection has improved, increasing the diagnosis of localized-stage cancers and survival rates. Korea recorded the lowest M/I ratio among major comparison countries, demonstrating the effectiveness of its National Cancer Control Program. Copyright 2025by theKoreanCancerAssociation. ⓘ Park, Eun Hye; Jung, Kyu-Won; Park, Nam Ju; Kang, Mee Joo; Hwa Yun, E.; Kim, Hye-Jin; Kim, Jeong-Eun; Kong, Hyun-Joo; Choi, Kui-Son; Yang, Han-Kwang; Kim, Chang-Hoon; Yoo, Cheolin; Kim, Yong-Dae; Kim, Young-Taek; Park, Kyung-Ki; Youm, Jung-Ho; Lim, Kyu-Hyoung; Shin, Ji-Yeon; Kweon, Sun-Seog; Kim, Hwan-Cheol; Park, Ki-Soo ⓘ Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea; Busan Cancer Registry, Pusan National University Hospital, South Korea; Ulsan Cancer Registry, Ulsan University Hospital, South Korea; Chungbuk Cancer Registry, Chungbuk National University Hospital, South Korea; Daejeon/Chungnam Cancer Registry, Chungnam National University and Hospital, South Korea; Jeju Cancer Registry, Jeju National University Hospital, South Korea; Chungbuk Cancer Registry, Chungbuk National University Hospital, South Korea; Kangwon Cancer Registry, Kangwon National University Hospital, South Korea; Daegu/Gyeongbuk Cancer Registry, Kyungpook National University Hospital, South Korea; Gwangju/Jeonnam Cancer Registry, Chonnam National University Hwasun Hospital, South Korea; Incheon Cancer Registry, Inha University Hospital, South Korea; Gyeongnam Cancer Registry, Gyeongsang National University Hospital, South Korea ⓘ ⓘ 56260883400; 7402479862; 58985047400; 23018377700; 55322512800; 57194054637; 58984964600; 57202469400; 59656311200; 59744467700; 57203626040; 7201746392; 8277138500; 57211411051; 59748458300; 58406928700; 24177182600; 59878918200; 7003824608; 40261776000; 59747842900 ⓘ ara@ncc.re.kr; ⓘ Cancer Research and Treatment ⓘ CANCER RES TREAT ⓘ 1598-2998 2005-9256 57 2 SCIE ONCOLOGY ⓘ 2024 3.8 30.8 0 2025-05-07 ⓘ 2 ⓘ ⓘ Incidence; Korea; Mortality; Neoplasms; Prevalence; Survival ⓘ Adult; Aged; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Prevalence; Republic of Korea; Survival Rate; adolescent; adult; aged; Article; bladder cancer; brain cancer; breast cancer; cancer incidence; cancer mortality; cancer staging; cancer statistics; cancer survival; carcinoma in situ; central nervous system cancer; colon cancer; colorectal cancer; crude mortality rate; esophagus cancer; female; gallbladder cancer; Hodgkin disease; human; infant; kidney cancer; larynx cancer; leukemia; lip cancer; liver cancer; lung cancer; major clinical study; male; mouth cancer; multiple myeloma; newborn; non-Hodgkin lymphoma; ovary cancer; pancreas cancer; pharynx cancer; prevalence; prostate cancer; rectum cancer; South Korea; stomach cancer; survival rate; testis cancer; thyroid cancer; trend study; uterine cervix cancer; uterus cancer; epidemiology; incidence; middle aged; mortality; neoplasm; prevalence; South Korea ⓘ English Final 2025 10.4143/crt.2025.264 ⓘ 바로가기 바로가기 바로가기
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