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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Tumor-derived OBP2A promotes prostate cancer castration resistance | This study unveils that OBP2A from PCa in remission during ADT enhances PCa growth and MDSCs infiltration through interaction with CXCL15/IL8, leading to CRPC emergence. Targeting OBP2A of tumor in remission would be effective therapeutic strategy for advanced PCa. Androgen deprivation therapy (ADT) is a systemic therapy for advanced prostate cancer (PCa); although most patients initially respond to ADT, almost all cancers eventually develop castration-resistant PCa (CRPC). Currently, most research focuses on castration-resistant tumors, and the role of tumors in remission is almost completely ignored. Here, we report that odorant-binding protein (OBP2A) released from tumors in remission during ADT catches survival factors, such as CXCL15/IL8, to promote PCa cell androgen-independent growth and enhance the infiltration of myeloid-derived suppressor cells (MDSCs) into tumor microenvironment, leading to the emergence of castration resistance. OBP2A knockdown significantly inhibits CRPC and metastatic CRPC development and improves therapeutic efficacy of CTLA-4/PD-1 antibodies. Treatment with OBP2A-binding ligand alpha-pinene interrupts the function of OBP2A and suppresses CRPC development. Furthermore, alpha-pinene-conjugated doxorubicin/docetaxel can be specifically delivered to tumors, resulting in improved anticancer efficacy. Thus, our studies establish a novel concept for the emergence of PCa castration resistance and provide new therapeutic strategies for advanced PCa. | Jeong, Ji-Hak; Zhong, Shangwei; Li, Fuzhuo; Huang, Changhao; Chen, Xueyan; Liu, Qingqing; Peng, Shoujiao; Park, HaJeung; Lee, You Mie; Dhillon, Jasreman; Luo, Jun-Li | Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, MRC, Daegu, South Korea; Univ South China, Hengyang Med Sch, Canc Res Inst, Hengyang, Peoples R China; Scripps Res Inst, Dept Chem, Jupiter, FL USA; Scripps Res Inst, X ray Core Facil, Jupiter, FL USA; H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, Tampa, FL USA | Chen, Rainie/ISS-6016-2023; Lee, Kyung-Soo/C-9016-2011; Huang, Changhao/LHA-6143-2024 | jlluo@usc.edu.cn; | JOURNAL OF EXPERIMENTAL MEDICINE | J EXP MED | 0022-1007 | 1540-9538 | 220 | 3 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 15.3 | 2.6 | 12 | ODORANT-BINDING PROTEIN; ANDROGEN DEPRIVATION THERAPY; REDUCED CLINICAL BENEFIT; MYELOID CELLS; ESSENTIAL OIL; ALPHA-PINENE; INTERLEUKIN-8; PROGRESSION; INDEPENDENCE; MECHANISMS | English | 2022 | 2022-12-22 | 10.1084/jem.20211546 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Meeting Abstract | Clinical implication of KRAS mutation variants in patients with resected colon cancer | Baek, Jin Ho; Kang, Byung Woog; Choi, Gyu Seog; Kim, Jong Gwang | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hematol & Oncol, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Sugery, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Dept Oncol Hematol, Daegu, South Korea | Kim, Sung-Bae/JXL-8219-2024 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 40 | 4 | SCIE | ONCOLOGY | 2022 | 45.4 | 2.7 | 0 | English | 2022 | 2022-02-01 | 10.1200/jco.2022.40.4_suppl.179 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | ○ | Article | Development of a parallel CUDA algorithm for solving 3D guiding center problems | In this study, we develop a novel compute unified device architecture (CUDA) algorithm, which we call C-ECM3, for solving a three-dimensional (3D) guiding center problem. The C-ECM3 is a parallel algorithm for the iterative-free backward semi-Lagrangian method with third-order temporal accuracy (ECM3). One well known challenge in speeding up a CUDA program is to efficiently design kernel functions that can optimally use hierarchical memory classified according to access speed. To solve this challenge, the C-ECM3 is mainly devoted to making a decomposition strategy for solving the tremendous number of generated Cauchy problems. The decomposition strategy divides the 9 x 9 linear system for each Cauchy problem in the ECM3 into two 3 x 3 linear systems, more solverable parts. In addition, the strategy explicitly solves these small systems using Cramer's rule. It turns out that the proposed C-ECM3 enables us to design an array-free kernel function that efficiently uses hierarchical memory. In addition, the C-ECM3 significantly reduces the run-time for tracing trajectories of particles compared to other graphics processing unit (GPU) programs that use the usual Gaussian algorithm. The Kelvin-Helmholtz instability and a 3D guiding center problem are simulated to demonstrate the numerical evidence for the C-ECM3. With these numerical experiments, we verify that the proposed C-ECM3 significantly improves computational speed compared to other methods while maintaining the accuracy of the CPU (central processing unit) version of ECM3. The validity of the C-ECM3 is also confirmed by showing that it satisfies Shoucri's analysis for Kelvin-Helmholtz instability. (C) 2022 Elsevier B.V. All rights reserved. | Bak, Soyoon; Kim, Philsu; Park, Sangbeom | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | Bak, Soyoon/HSE-8486-2023 | 56450371300; 7402334786; 57374873000 | jiya525@knu.ac.kr;kimps@knu.ac.kr;piaoxf76@hanmail.net; | COMPUTER PHYSICS COMMUNICATIONS | COMPUT PHYS COMMUN | 0010-4655 | 1879-2944 | 276 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;PHYSICS, MATHEMATICAL | 2022 | 6.2 | 2.7 | 0.4 | 2025-06-25 | 4 | 5 | Compute unified device architecture; Graphics processing units; Parallel computing; Backward semi-Lagrangian method; Guiding center problem | SEMI-LAGRANGIAN SCHEME; ORDER CHARACTERISTICS/FINITE ELEMENTS; DIFFUSION-REACTION PROBLEMS; NUMERICAL-ANALYSIS; 2ND-ORDER; TIME; INTEGRATION; SIMULATION | Backward semi-Lagrangian method; Compute unified device architecture; Graphics processing units; Guiding center problem; Parallel computing | C (programming language); Computer graphics equipment; Graphics processing unit; Iterative methods; Lagrange multipliers; Memory architecture; Numerical methods; Parallel architectures; Program processors; Three dimensional computer graphics; Backward semi-lagrangian method; Center problems; Compute unified device architecture; Device architectures; Graphic processing unit; Graphics processing; Guiding center problem; Guiding centers; Parallel com- puting; Processing units; Semi-Lagrangian methods; Linear systems | English | 2022 | 2022-07 | 10.1016/j.cpc.2022.108331 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Estrogen-Related Receptor γ Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism | BACKGROUND & AIMS: Mitochondrial dysfunction disrupts the synthesis and secretion of digestive enzymes in pancreatic acinar cells and plays a primary role in the etiology of exocrine pancreas disorders. However, the transcriptional mechanisms that regulate mitochondrial function to support acinar cell physiology are poorly understood. Here, we aim to elucidate the function of estrogen-related receptor gamma (ERR gamma) in pancreatic acinar cell mitochondrial homeostasis and energy production. METHODS: Two models of ERR gamma inhibition, GSK5182-treated wild-type mice and ERR gamma conditional knockout (cKO) mice, were established to investigate ERR gamma function in the exocrine pancreas. To identify the functional role of ERR gamma in pancreatic acinar cells, we performed histologic and transcriptome analysis with the pancreas isolated from ERR gamma cKO mice. To determine the relevance of these findings for human disease, we analyzed transcriptome data from multiple independent human cohorts and conducted genetic association studies for ESRRG variants in 2 distinct human pancreatitis cohorts. RESULTS: Blocking ERR gamma function in mice by genetic deletion or inverse agonist treatment results in striking pancreatitis-like phenotypes accompanied by inflammation, fibrosis, and cell death. Mechanistically, loss of ERR gamma in primary acini abrogates messenger RNA expression and protein levels of mitochondrial oxidative phosphorylation complex genes, resulting in defective acinar cell energetics. Mitochondrial dysfunction due to ERR gamma deletion further triggers autophagy dysfunction, endoplasmic reticulum stress, and production of reactive oxygen species, ultimately leading to cell death. Interestingly, ERR gamma-deficient acinar cells that escape cell death acquire ductal cell characteristics, indicating a role for ERR gamma in acinar-to-ductal metaplasia. Consistent with our findings in ERR gamma cKO mice, ERR gamma expression was significantly reduced in patients with chronic pancreatitis compared with normal subjects. Furthermore, candidate locus region genetic association studies revealed multiple single nucleotide variants for ERR gamma that are associated with chronic pancreatitis. CONCLUSIONS: Collectively, our findings highlight an essential role for ERR gamma in maintaining the transcriptional program that supports acinar cell mitochondrial function and organellar homeostasis and provide a novel molecular link between ERR gamma and exocrine pancreas disorders. | Choi, Jinhyuk; Oh, Tae Gyu; Jung, Hee-Won; Park, Kun-Young; Shin, Hyemi; Jo, Taehee; Kang, Du-Seock; Chanda, Dipanjan; Hong, Sujung; Kim, Jina; Hwang, Hayoung; Ji, Moongi; Jung, Minkyo; Shoji, Takashi; Matsushima, Ayami; Kim, Pilhan; Mun, Ji Young; Paik, Man-Jeong; Cho, Sung Jin; Lee, In-Kyu; Whitcomb, David C.; Greer, Phil; Blobner, Brandon; Goodarzi, Mark O.; Pandol, Stephen J.; Rotter, Jerome, I; Fan, Weiwei; Bapat, Sagar P.; Zheng, Ye; Liddle, Chris; Yu, Ruth T.; Atkins, Annette R.; Downes, Michael; Yoshihara, Eiji; Evans, Ronald M.; Suh, Jae Myoung | Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Salk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea; Sunchon Natl Univ, Coll Pharm, Sunchon, South Korea; Korea Brain Res Inst, Neural Circuit Res Grp, Daegu, South Korea; Kyoto Univ, Dept Med, Kyoto, Japan; Kyushu Univ, Fac Sci, Dept Chem, Lab Struct Funct Biochem, Fukuoka, Japan; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Kyungpook Natl Univ Hosp, Daegu, South Korea; Ariel Precis Med, Pittsburgh, PA USA; Univ Pittsburgh, Dept Med, Pittsburgh, PA USA; Univ Pittsburgh, Dept Cell Biol & Mol Physiol, Pittsburgh, PA USA; Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA; Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA; Cedars Sinai Med Ctr, Cedars Sinai Canc, Los Angeles, CA 90048 USA; Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA; Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Lundquist Inst Biomed Innovat, Dept Pediat, Torrance, CA 90509 USA; Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA; Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA; Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA; Salk Inst Biol Studies, Nomis Labs Immunobiol & Microbial Pathogenesis, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA; Univ Sydney, Storr Liver Ctr, Westmead Inst Med Res, Westmead, NSW, Australia; Univ Sydney, Sydney Sch Med, Westmead, NSW, Australia; Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Torrance, CA 90509 USA; Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA | ; Kim, Pilhan/C-1836-2011; Chanda, Dipanjan/AAU-3996-2021; Jung, Hee-Won/B-4269-2015; Greer, Phil/GZL-2084-2022; Jung, Minkyo/HMP-0550-2023; Rotter, Jerome/AAY-6598-2021; Liddle, Christopher/IZE-3784-2023; Goodarzi, Mark/AAH-7106-2021; Frank, Viki/GXZ-9902-2022; Mun, Jiyoung/IUN-3520-2023; Evans, Ronald/AAF-4001-2019; Suh, Jae Myoung/B-3268-2015; Suh, Jae/B-3268-2015; Lee, In-Kyu/AAR-6374-2021; Zheng, Ye/G-4866-2015 | 59643638200; 57205684733; 56301447800; 57214823513; 57202421211; 57214243688; 56594126200; 16416525900; 57210788194; 56949261900; 57112963600; 57201341628; 55701234000; 57715305100; 7005364090; 55846745900; 8654053900; 7005745969; 58735369700; 59060573600; 7102078518; 7004605887; 37074080200; 7004517118; 35465340400; 56284453500; 56435158100; 56524998100; 57203490059; 55865672000; 7401436247; 35547470600; 7005653144; 56085265700; 35355415600; 36799636000 | eiji.yoshihara@lundquist.org;evans@salk.edu;jmsuh@kaist.ac.kr; | GASTROENTEROLOGY | GASTROENTEROLOGY | 0016-5085 | 1528-0012 | 163 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 29.4 | 2.7 | 2.18 | 2025-06-25 | 29 | 25 | ERR gamma; Pancreatic Acinar Cells; Mitochondrial Oxidative Phosphorylation; Reactive Oxygen Species; Acinar-to-Ductal Metaplasia | ERR-GAMMA; DYSFUNCTION; REGENERATION; PATHOGENESIS; AUTOPHAGY; LACKING; STRESS; SWITCH; STATES | Acinar-to-Ductal Metaplasia; ERRγ; Mitochondrial Oxidative Phosphorylation; Pancreatic Acinar Cells; Reactive Oxygen Species | Acinar Cells; Animals; Estrogens; Humans; Mice; Mice, Knockout; Pancreas; Pancreas, Exocrine; Pancreatitis, Chronic; estrogen receptor; estrogen related receptor gamma; messenger RNA; reactive oxygen metabolite; tiletamine plus zolazepam; transcriptome; unclassified drug; xylazine; estrogen; acinar cell; adult; animal cell; animal experiment; animal tissue; Article; cell death; cell energy; cell function; cell metabolism; chronic pancreatitis; controlled study; endoplasmic reticulum stress; energy yield; exocrine pancreas; female; gene deletion; gene expression; genetic association study; homeostasis; human; male; mitochondrion; mouse; nonhuman; oxidative phosphorylation; acinar cell; animal; chronic pancreatitis; exocrine pancreas; knockout mouse; metabolism; pancreas; pathology | English | 2022 | 2022-07 | 10.1053/j.gastro.2022.04.013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Further Results on Sampled-Data H∞ Filtering for T-S Fuzzy Systems With Asynchronous Premise Variables | This article presents a new sampled-data fuzzy filter design method for Takagi-Sugeno fuzzy systems with the asynchronous premise variables. In the new fuzzy filter design method, the membership functions of the filter are affine transformed by scaling and biasing the system's membership functions. Taking the advantage of the newly proposed method, the asynchronous problem of the premise variables between the system and filter is easily resolved. Based on the looped function and a modified free-weighting matrix inequality, the sampled system's output is handled, and the filter design condition is formulated in terms of a parameterized linear matrix inequality with affine matched fuzzy parameter vectors. Additionally, a modified Finsler's lemma is devised to handle the affine matched fuzzy parameter vectors. By utilizing the relationship between the transformed membership functions, the filter design condition for H-infinity performance is enhanced with larger allowable maximum bounds of variable sampling intervals. Lastly, the superiority of the presented method is verified by comparing the numerical simulations with existing methods. | Jin, Yongsik; Kwon, Wookyong; Lee, Sangmoon | Elect & Telecommun Res Inst, Daegu 42994, South Korea; Kyungpook Natl Univ, Cyber Phys Syst & Control Lab, Sch Elect & Elect Engn, Daegu 41566, South Korea | ; Jin, Yongsik/AAH-6959-2021; Lee, Sangmoon/C-4502-2018 | 57020309300; 57212541649; 59510733500 | yongsik@etri.re.kr;wkwon@etri.re.kr;moony@knu.ac.kr; | IEEE TRANSACTIONS ON FUZZY SYSTEMS | IEEE T FUZZY SYST | 1063-6706 | 1941-0034 | 30 | 6 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, ELECTRICAL & ELECTRONIC | 2022 | 11.9 | 2.7 | 2.01 | 2025-06-25 | 21 | 23 | Fuzzy filtering; fuzzy membership functions; LMIs; modified Finsler's lemma; sampled-data systems | STABILITY ANALYSIS; RELAXED STABILITY; DESIGN; STABILIZATION | Fuzzy filtering; fuzzy membership functions; LMIs; modified Finslera's lemma; sampled-data systems | Design; Feedback control; Linear matrix inequalities; Linear systems; Matched filters; Membership functions; Numerical methods; Passive filters; Filter designs; Free-weighting matrices; Fuzzy parameter; Parameterized linear matrix inequality; Sampled systems; T S fuzzy system; Takagi Sugeno fuzzy systems; Variable sampling intervals; Fuzzy filters | English | 2022 | 2022-06 | 10.1109/tfuzz.2021.3069319 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Lactate dehydrogenase as a surrogate marker for both PCR and survival in breast cancer patients who underwent neoadjuvant chemotherapy. | Lee, In Hee; Chae, Yee Soo; Lee, Jeeyeon; Park, Ho Yong; Jung, Jin Hyang; Park, Ji-Young; Park, Jee-Young | Kyungpook Natl Univ, Chilgok Hosp, Dept Oncol Hematol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Dept Surg, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Pathol, Sch Med, Daegu, South Korea; KNUCH, Daegu, South Korea | PARK, JUN-YOUNG/P-5981-2015; Park, Jung Hwan/AAA-1951-2022; Park, Jin-Young/HDN-0483-2022 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 40 | 16 | SCIE | ONCOLOGY | 2022 | 45.4 | 2.7 | 0 | English | 2022 | 2022-06-01 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Review | Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review | Almost all aspects of society from food security to disease control and prevention have benefited from pharmaceutical and personal care products, yet these products are a major source of contamination that ends up in wastewater and ecosystems. This issue has been sharply accentuated during the coronavirus disease pandemic 2019 (COVID-19) due to the higher use of disinfectants and other products. Here we review pharmaceutical and personal care products with focus on their occurrence in the environment, detection, risk, and removal. | Anand, Uttpal; Adelodun, Bashir; Cabreros, Carlo; Kumar, Pankaj; Suresh, S.; Dey, Abhijit; Ballesteros, Florencio, Jr.; Bontempi, Elza | Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Univ Philippines, Natl Grad Sch Engn, Environm Engn Program, 1101 Diliman, Quezon City, Philippines; Gurukula Kangri Deemed Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, Uttarakhand, India; Maulana Azad Natl Inst Technol, Dept Chem Engn, Bhopal 462003, Madhya Pradesh, India; Presidency Univ, Dept Life Sci, 86-1 Coll St, Kolkata 700073, W Bengal, India; Univ Brescia, INSTM, Via Branze 38, I-25123 Brescia, Italy; Univ Brescia, Chem Technol Lab, Via Branze 38, I-25123 Brescia, Italy; Ben Gurion Univ Negev, Zuckerberg Inst Water Res, Jacob Blaustein Inst Desert Res, IL-8499000 Midreshet Ben Gurion, Israel | Bontempi, Elza/F-3216-2010; Dey, Abhijit/AAG-2439-2020; Kumar, Pankaj/AAF-2231-2019; Adelodun, Bashir/O-2941-2018 | 57211622603; 57193774482; 57222866770; 57281192700; 22935957500; 36898179400; 36664314600; 57213004303 | ushuats@gmail.com;elza.bontempi@unibs.it; | ENVIRONMENTAL CHEMISTRY LETTERS | ENVIRON CHEM LETT | 1610-3653 | 1610-3661 | 20 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2022 | 15.7 | 2.7 | 1.94 | 2025-06-25 | 94 | 109 | Pharmaceutical and personal care products (PPCPs); Active pharmaceutical ingredients; Wastewater treatment plants; Environmental pollution; Human health risk assessment; COVID-19 | SEWAGE-TREATMENT PLANTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; BAR SORPTIVE EXTRACTION; SOLID-PHASE EXTRACTION; EMERGING CONTAMINANTS; GAS-CHROMATOGRAPHY; DRINKING-WATER; SURFACE WATERS; ILLICIT DRUGS; ORGANIC MICROPOLLUTANTS | Active pharmaceutical ingredients; COVID-19; Environmental pollution; Human health risk assessment; Pharmaceutical and personal care products (PPCPs); Wastewater treatment plants | Active pharmaceuticals ingredients; Control and prevention; Coronavirus disease pandemic 2019; Coronaviruses; Environmental pollutions; Food security; Human health risk assessment; Pharmaceutical and personal care product; Pharmaceutical and personal care products; Waste water treatment plants; COVID-19 | English | 2022 | 2022-12 | 10.1007/s10311-022-01498-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Safety and efficacy of durvalumab plus bevacizumab in unresectable hepatocellular carcinoma: Results from the phase 2 study 22 (NCT02519348) | Lim, Ho Yeong; Heo, Jeong; Kim, Tae-You; Tai, Wai Meng David; Kang, Yoon-Koo; Lau, George; Kudo, Masatoshi; Tak, Won Young; Watras, Magdalena; Ali, Sajid K.; Negro, Alejandra; Abou-Alfa, Ghassan K.; Kelley, Robin Kate | Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Busan, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Natl Canc Ctr Singapore, Singapore, Singapore; Asan Med Ctr, Seoul, South Korea; Human & Hlth Med Grp, Human & Hlth Clin Trial Ctr, Hong Kong, Peoples R China; Kindai Univ, Sch Med, Osaka, Japan; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Daegu, South Korea; AstraZeneca, Warsaw, Poland; AstraZeneca, Cambridge, England; AstraZeneca, Gaithersburg, MD USA; Cornell Univ, Mem Sloan Kettering Canc Ctr, New York, NY USA; Cornell Univ, Weill Cornell Med Coll, New York, NY USA; Univ Calif San Francisco, San Francisco, CA 94143 USA | Kudo, Masatoshi/AAA-9744-2019; Lau, George/AAQ-2085-2021; Kang, Yoon-Koo/ABL-4264-2022; Lim, Ho Yeong/KBA-8868-2024; Heo, Jeong/MHQ-1390-2025 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 40 | 4 | SCIE | ONCOLOGY | 2022 | 45.4 | 2.7 | 5 | English | 2022 | 2022-02-01 | 10.1200/jco.2022.40.4_suppl.436 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | Meeting Abstract | Trastuzumab deruxtecan (T-DXd) versus treatment of physician's choice (TPC) in patients (pts) with HER2-low unresectable and/or metastatic breast cancer (mBC): Results of DESTINY-Breast04, a randomized, phase 3 study. | Modi, Shanu; Jacot, William; Yamashita, Toshinari; Sohn, Joohyuk; Vidal, Maria; Tokunaga, Eriko; Tsurutani, Junji; Ueno, Naoto T.; Chae, Yee Soo; Lee, Keun Seok; Niikura, Naoki; Park, Yeon Hee; Wang, Xiaojia; Xu, Binghe; Gambhire, Dhiraj; Yung, Lotus; Meinhardt, Gerold; Wang, Yibin; Harbeck, Nadia; Cameron, David A. | Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA; Montpellier Univ, Inst Canc Montpellier ICM Val dAurelle, Montpellier, France; Kanagawa Canc Ctr, Yokohama, Kanagawa, Japan; Yonsei Canc Ctr, Seoul, South Korea; Hosp Clin Barcelona, Barcelona, Spain; Natl Hosp Org Kyushu Canc Ctr, Fukuoka, Japan; Showa Univ, Adv Canc Translat Res Inst, Tokyo, Japan; Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Natl Canc Ctr, Res Inst & Hosp, Goyang, South Korea; Tokai Univ, Tokyo, Japan; Samsung Med Ctr, Seoul, South Korea; Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou, Peoples R China; Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China; Chinese Acad Med Sci, Coll Med, Canc Hosp, Beijing, Peoples R China; Daiichi Sankyo Inc, Basking Ridge, NJ USA; Ludwig Maximilians Univ LMU Hosp, Ctr Comprehens Canc, Munich, Germany; Univ Edinburgh, Edinburgh Canc Res Ctr, Edinburgh, Midlothian, Scotland; NHS Lothian, Edinburgh, Midlothian, Scotland | Cameron, David/C-7781-2013; Losada, Maria/AAJ-8633-2021; Harbeck, Nadia/JOZ-6178-2023 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 40 | 17 | SCIE | ONCOLOGY | 2022 | 45.4 | 2.7 | 36 | English | 2022 | 2022-06-10 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Letter | Comment on: Obesity is Associated with Improved Postoperative Overall Survival, Independent of Skeletal Muscle Mass in Lung Adenocarcinoma by Lee et al. | Lee, Duk-Hee | Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea | 57211851121 | lee_dh@knu.ac.kr; | JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | J CACHEXIA SARCOPENI | 2190-5991 | 2190-6009 | 13 | 5 | SCIE | GERIATRICS & GERONTOLOGY;MEDICINE, GENERAL & INTERNAL | 2022 | 8.9 | 2.8 | 0 | 2025-06-25 | 0 | 0 | PERSISTENT ORGANIC POLLUTANTS; ADIPOSE-TISSUE; WEIGHT-LOSS; POLYCHLORINATED-BIPHENYLS; BREAST-MILK; PESTICIDES; CHEMICALS; BLOOD; DIET | Adenocarcinoma of Lung; Humans; Lung Neoplasms; Muscle, Skeletal; Obesity; 2,3,7,8 tetrachlorodibenzo para dioxin; 4,4' isopropylidenediphenol; dioxin; nonylphenol; organochlorine pesticide; phthalic acid; polybrominated diphenyl ether; polychlorinated biphenyl; polycyclic aromatic hydrocarbon; triclosan; adipose tissue; cancer prognosis; disease association; human; Letter; lung adenocarcinoma; muscle mass; nonhuman; obesity; overall survival; postoperative period; randomized controlled trial (topic); skeletal muscle; complication; lung tumor; obesity; pathology; skeletal muscle | English | 2022 | 2022-10 | 10.1002/jcsm.13060 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system-dependent muscle atrophy | Background Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscle and has been implicated in the pathogenesis of several diseases. The current study was designed to investigated and delineate the role of PDK4 in the context of muscle atrophy, which could be identified as a potential therapeutic avenue to protect against dexamethasone-induced muscle wasting. Methods The dexamethasone-induced muscle atrophy in C2C12 myotubes was evaluated at the molecular level by expression of key genes and proteins involved in myogenesis, using immunoblotting and qPCR analyses. Muscle dysfunction was studied in vivo in wild-type and PDK4 knockout mice treated with dexamethasone (25 mg/kg body weight, i.p., 10 days). Body weight, grip strength, muscle weight and muscle histology were assessed. The expression of myogenesis markers were analysed using qPCR, immunoblotting and immunoprecipitation. The study was extended to in vitro human skeletal muscle atrophy analysis. Results Knockdown of PDK4 was found to prevent glucocorticoid-induced muscle atrophy and dysfunction in C2C12 myotubes, which was indicated by induction of myogenin (0.3271 +/- 0.102 vs 2.163 +/- 0.192, ****P < 0.0001) and myosin heavy chain (0.3901 +/- 0.047 vs. 0.7222 +/- 0.082, ** P < 0.01) protein levels and reduction of muscle atrophy F-box (10.77 +/- 2.674 vs. 1.518 +/- 0.172, **P < 0.01) expression. In dexamethasone-induced muscle atrophy model, mice with genetic ablation of PDK4 revealed increased muscle strength (162.1 +/- 22.75 vs. 200.1 +/- 37.09 g, ***P < 0.001) and muscle fibres (54.20 +/- 11.85% vs. 84.07 +/- 28.41%, ****P < 0.0001). To explore the mechanism, we performed coimmunoprecipitation and liquid chromatography-mass spectrometry analysis and found that myogenin is novel substrate of PDK4. PDK4 phosphorylates myogenin at S43/T57 amino acid residues, which facilitates the recruitment of muscle atrophy F-box to myogenin and leads to its subsequent ubiquitination and degradation. Finally, overexpression of non-phosphorylatable myogenin mutant using intramuscular injection prevented dexamethasone-induced muscle atrophy and preserved muscle fibres. Conclusions We have demonstrated that PDK4 mediates dexamethasone-induced skeletal muscle atrophy. Mechanistically, PDK4 phosphorylates and degrades myogenin via recruitment of E3 ubiquitin ligase, muscle atrophy F-box. Rescue of muscle regeneration by genetic ablation of PDK4 or overexpression of non-phosphorylatable myogenin mutant indicates PDK4 as an amenable therapeutic target in muscle atrophy. | Sinam, Ibotombi Singh; Chanda, Dipanjan; Thoudam, Themis; Kim, Min-Ji; Kim, Byung-Gyu; Kang, Hyeon-Ji; Lee, Jung Yi; Baek, Seung-Hoon; Kim, Shin-Yoon; Shim, Bum Jin; Ryu, Dongryeol; Jeon, Jae-Han; Lee, In-Kyu | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Inst Basic Sci IBS, Ctr Genom Integr CGI, Dept Biol Sci, Ulsan, South Korea; Kyungpook Natl Univ, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Min-Ji/Z-5205-2019; Kim, Byung-Gyu/GYD-6151-2022; Kim, Soo/J-5411-2012; Lee, In-Kyu/AAR-6374-2021; Ryu, Dongryeol/AAQ-3642-2020; thoudam, themis/ACM-3919-2022 | 57846985600; 16416525900; 57192905626; 57206189095; 55797167500; 55946300800; 57195563161; 56232924900; 26663842900; 57201499293; 57201809600; 36910340400; 36071537600 | jeonjh@knu.ac.kr;leei@knu.ac.kr; | JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | J CACHEXIA SARCOPENI | 2190-5991 | 2190-6009 | 13 | 6 | SCIE | GERIATRICS & GERONTOLOGY;MEDICINE, GENERAL & INTERNAL | 2022 | 8.9 | 2.8 | 3.26 | 2025-06-25 | 24 | 25 | PDK4; myogenin; ubiquitin-proteasomal system; phosphorylation; glucocorticoids; muscle atrophy | SKELETAL-MUSCLE; MYOGENIN GENE; UP-REGULATION; EXPRESSION; TRANSCRIPTION; INHIBITION; PROTEIN; ACTIVATION; MECHANISMS; MYOPATHY | glucocorticoids; muscle atrophy; myogenin; PDK4; phosphorylation; ubiquitin–proteasomal system | Animals; Body Weight; Dexamethasone; Glucocorticoids; Humans; Mice; Muscular Atrophy; Proteasome Endopeptidase Complex; Ubiquitin; amino acid; atrogin 1; dexamethasone; F box protein; messenger RNA; muscle RING finger 1 protein; myogenin; myosin heavy chain; proteasome; pyruvate dehydrogenase kinase 4; ubiquitin; dexamethasone; glucocorticoid; proteasome; pyruvate dehydrogenase kinase 4; ubiquitin; animal cell; animal experiment; animal model; animal tissue; Article; C2C12 cell line; cachexia; cell differentiation; coimmunoprecipitation; controlled study; down regulation; enzyme phosphorylation; gastrocnemius muscle; gene knockdown; gene overexpression; grip strength; grip strength test; human; human cell culture; human tissue; immunoblotting; immunoprecipitation; in vitro study; in vivo study; liquid chromatography-mass spectrometry; male; mouse; mRNA expression level; muscle atrophy; muscle development; muscle regeneration; muscle strength; muscle tissue; muscle weight; myotube; nonhuman; protein degradation; protein depletion; protein expression level; real time polymerase chain reaction; skeletal muscle cell; ubiquitination; upregulation; animal; body weight; muscle atrophy | English | 2022 | 2022-12 | 10.1002/jcsm.13100 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Skeletal muscle mitoribosomal defects are linked to low bone mass caused by bone marrow inflammation in male mice | Background Mitochondrial oxidative phosphorylation (OxPhos) is a critical regulator of skeletal muscle mass and function. Although muscle atrophy due to mitochondrial dysfunction is closely associated with bone loss, the biological characteristics of the relationship between muscle and bone remain obscure. We showed that muscle atrophy caused by skeletal muscle-specific CR6-interacting factor 1 knockout (MKO) modulates the bone marrow (BM) inflammatory response, leading to low bone mass. Methods MKO mice with lower muscle OxPhos were fed a normal chow or high-fat diet and then evaluated for muscle mass and function, and bone mineral density. Immunophenotyping of BM immune cells was also performed. BM transcriptomic analysis was used to identify key factors regulating bone mass in MKO mice. To determine the effects of BM-derived CXCL12 (C-X-C motif chemokine ligand 12) on regulation of bone homeostasis, a variety of BM niche-resident cells were treated with recombinant CXCL12. Vastus lateralis muscle and BM immune cell samples from 14 patients with hip fracture were investigated to examine the association between muscle function and BM inflammation. Results MKO mice exhibited significant reductions in both muscle mass and expression of OxPhos subunits but increased transcription of mitochondrial stress response-related genes in the extensor digitorum longus (P < 0.01). MKO mice showed a decline in grip strength and a higher drop rate in the wire hanging test (P < 0.01). Micro-computed tomography and von Kossa staining revealed that MKO mice developed a low mass phenotype in cortical and trabecular bone (P < 0.01). Transcriptomic analysis of the BM revealed that mitochondrial stress responses in skeletal muscles induce an inflammatory response and adipogenesis in the BM and that the CXCL12-CXCR4 (C-X-C chemokine receptor 4) axis is important for T-cell homing to the BM. Antagonism of CXCR4 attenuated BM inflammation and increased bone mass in MKO mice. In humans, patients with low body mass index (BMI = 17.2 +/- 0.42 kg/m(2)) harboured a larger population of proinflammatory and cytotoxic senescent T-cells in the BMI (P < 0.05) and showed reduced expression of OxPhos subunits in the vastus lateralis, compared with controls with a normal BMI (23.7 +/- 0.88 kg/m(2)) (P < 0.01). Conclusions Defects in muscle mitochondrial OxPhos promote BM inflammation in mice, leading to decreased bone mass. Muscle mitochondrial dysfunction is linked to BM inflammatory cytokine secretion via the CXCL12-CXCR4 signalling axis, which is critical for inducing low bone mass. | Tian, Jingwen; Chung, Hyo Kyun; Moon, Ji Sun; Nga, Ha Thi; Lee, Ho Yeop; Kim, Jung Tae; Chang, Joon Young; Kang, Seul Gi; Ryu, Dongryeol; Che, Xiangguo; Choi, Je-Yong; Tsukasaki, Masayuki; Sasako, Takayoshi; Lee, Sang-Hee; Shong, Minho; Yi, Hyon-Seung | Chungnam Natl Univ, Dept Med Sci, Daejeon, South Korea; Chungnam Natl Univ, Lab Endocrinol & Immune Syst, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Sch Med, Res Ctr Endocrine & Metab Dis, 282 Munhwaro, Daejeon 35015, South Korea; Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea; Samsung Med Ctr, Samsung Biomed Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Cell & Matrix Res Inst, BK21 Plus KNU Biomed Convergence Program,Sch Med, Seoul, South Korea; Yanbian Univ, Affiliated Hosp, Dept Internal Med Rheumatol & Immunol, Yanji, Peoples R China; Univ Tokyo, Dept Immunol, Grad Sch Med, Tokyo, Japan; Univ Tokyo, Fac Med, Tokyo, Japan; Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo, Japan; Korea Basic Sci Inst, Bioelectron Microscopy Res Ctr Dong 104, Cheongju, South Korea | shong, minho/H-7803-2012; Sasako, Takayoshi/AGE-7931-2022; Ryu, Dongryeol/AAQ-3642-2020; Yi, Hyon-Seung/ABA-2729-2022; Choi, Je-Yong/AAR-7334-2021 | 57218201812; 7404006841; 57207780661; 57218201578; 57221714890; 57192648211; 56510562400; 57192890832; 57201809600; 54792660600; 7501391068; 6508092892; 24391591800; 58743241400; 7003976276; 55376878100 | jmpbooks@cnu.ac.kr; | JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | J CACHEXIA SARCOPENI | 2190-5991 | 2190-6009 | 13 | 3 | SCIE | GERIATRICS & GERONTOLOGY;MEDICINE, GENERAL & INTERNAL | 2022 | 8.9 | 2.8 | 1.7 | 2025-06-25 | 14 | 14 | Mitochondria; Inflammation; Bone marrow; Bone loss | T-CELL-RECEPTOR; MINERAL DENSITY; GROWTH; DIFFERENTIATION; EXPRESSION; OSTEOBLAST; CXCL12; FAT | Bone loss; Bone marrow; Inflammation; Mitochondria | Animals; Bone Marrow; Humans; Inflammation; Male; Mice; Muscle, Skeletal; Muscular Atrophy; X-Ray Microtomography; chemokine receptor CXCR4; fibroblast growth factor 21; adipogenesis; animal cell; animal experiment; animal model; animal tissue; Article; body mass; bone density; bone marrow; bone mass; bone volume; cell homing; clinical article; controlled study; extensor digitorum longus muscle; flow cytometry; gastrocnemius muscle; grip strength; hip fracture; homeostasis; human; immunocompetent cell; immunophenotyping; in vitro study; inflammation; lipid diet; male; micro-computed tomography; mitochondrial ribosome; morphometry; mouse; multinuclear cell; muscle atrophy; muscle function; muscle mass; nonhuman; osteoclast; osteolysis; oxidative phosphorylation; phenotype; physical performance; physiological stress; real time polymerase chain reaction; RNA sequencing; skeletal muscle; T lymphocyte; T lymphocyte activation; trabecular bone; trabecular number; transcriptomics; vastus lateralis muscle; Western blotting; animal; inflammation; metabolism; pathology | English | 2022 | 2022-06 | 10.1002/jcsm.12975 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Upper Cretaceous (Coniacian-Santonian) dinosaur nesting colony preserved in abandoned crevasse splay deposits, Wi Island, South Korea | Dinosaur egg-bearing deposits of the Upper Cretaceous (Coniacian-Santonian) Wido Volcanics at Wi Island, South Korea, were studied from a taphonomic perspective to improve understanding of nesting behavior. Based on facies, bedset geometry, and other sedimentological characteristics, the section can be classified into three facies associations: (1) ephemeral fluvial channels (FA I), (2) crevasse splay lobes (FA II), and (3) floodplains (FA III). FA I is characterized by single- and multi-storey channel fills enclosed within FA III, while FA II consists of horizontally-stratified sandstone and calcareous mudstone reflecting weakly developed paleosol profiles. The ephemeral fluvial channels are locally developed at 160 m distance from the main egg locality, suggesting that the nesting site was relatively protected from levee failure and favorable for fossil preservation. Isolated eggs and reworked eggshell fragments of three different types (Propagoolithus widoensis, Reticuloolithus acicularis, and Aenigmaoolithus vesicularis) are frequently found together. The most common type, P. widoensis is preserved as clutches and characterized by numerous closely-spaced pore canals, indicating that the eggs were buried during oviposition, increasing preservation potential. Such in situ clutches occur in at least nine horizons and some occur closely spaced (<1 m apart), lateral to crevasse splay lobe successions (FA II). It suggests that the egg-layers of P. widoensis preferred this facies as a nesting ground for extended periods. FA II was deposited at a higher paleoelevation than FA III, which may have benefited nesting dinosaurs, allowing them to easily detect predators (FA III) while being less frequently exposed to flood hazards. | Kim, Seongyeong; Hwang, In Gul; Ghim, Yong Sik; Kim, Noe-Heon; Lee, Yuong-Nam | Seoul Natl Univ, Sch Earth & Environm Sci, Seoul 08826, South Korea; Korea Inst Geosci & Mineral Resources, Petr & Marine Res Div, 124 Gwahang Ro, Daejeon 305350, South Korea; Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea | Kim, Noe-Heon/MZR-6545-2025; Kim, Sooyeon/AAA-8521-2022 | 57224889966; 18436914800; 57210284942; 57202646125; 57211225071 | sykim2016@snu.ac.kr;ighwang@kigam.re.kr;naress@knu.ac.kr;ynlee@snu.ac.kr; | PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY | PALAEOGEOGR PALAEOCL | 0031-0182 | 1872-616X | 585 | SCIE | GEOGRAPHY, PHYSICAL;GEOSCIENCES, MULTIDISCIPLINARY;PALEONTOLOGY | 2022 | 3 | 2.8 | 0.58 | 2025-06-25 | 4 | 4 | Dinosaur nesting behavior; Paleontological site fidelity; Abandoned crevasse splays; Wi Island; Cretaceous; South Korea | NORTHWESTERN PART; KYONGSANG BASIN; ALLUVIAL-FAN; DEATH-VALLEY; HATEG BASIN; LA RIOJA; EGGS; ARCHITECTURE; FACIES; ENVIRONMENTS | Abandoned crevasse splays; Cretaceous; Dinosaur nesting behavior; Paleontological site fidelity; South Korea; Wi Island | Korea; South Korea; Dinosauria; Rosa acicularis acicularis; Cretaceous; crevasse; dinosaur; eggshell; nesting behavior; sandstone | English | 2022 | 2022-01-01 | 10.1016/j.palaeo.2021.110728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cellulose nanocrystal nanocomposites capable of low-temperature and fast self-healing performance | The development of low-temperature self-healing polymers is crucial because high-temperature or softening conditions for rapid self-healing inevitably reduce their mechanical strength. Herein, we first report cellulose nanocrystal (CNC)/polymer nanocomposites with a rapid low-temperature self-healing performance. The nanocomposite was prepared by simple blending of grafted CNC and matrix prepolymer made from the monomers having metal-ligand coordination and lower critical solution temperature functionalities along with the presence of hexamethylene diisocyanate and dibutyltin dilaurate. Owing to the dynamic nature of both hydrogen bonds and metal-ligand coordinated covalent bonds, the resultant nanocomposites showed excellent self-healing efficiency (99 %, within 1 h) at a low temperature (5 ?C) with robust mechanical properties including a high stretchability (230 %), high toughness (2538 MJ/m(3)), enhanced tensile strength (25.49 +/- 0.02 MPa), and improved thermomechanical properties. Self-healing performance of the coordinated covalent bonds requiring active hydrogen was considerably improved by the introduction of CNCs with abundant hydrogen bonds. | Saddique, Anam; Lee, Hyang Moo; Kim, Jin Chul; Bae, Jinhye; Cheong, In Woo | Kyungpook Natl Univ, Dept Appl Chem, 80 Daehak Ro, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, Dept Specialty Chem, Div Specialty & Biobased Chem Technol, Ulsan 44412, South Korea; Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA; Univ Calif San Diego, Chem Engn Program, La Jolla, CA 92093 USA | 57312386800; 55598631800; 56805502600; 56115343100; 7006733373 | jckim81@krict.re.kr;j3bae@ucsd.edu;inwoo@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 296 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2022 | 11.2 | 2.9 | 2.2 | 2025-06-25 | 23 | 24 | Cellulose nanocrystals; Coordinated covalent bonds; Nanocomposites; Self -healing | NANOFIBRILLATED CELLULOSE; MECHANICAL STRENGTH; HYDROGELS; POLYMER; RECOVERY; BEHAVIOR | Cellulose nanocrystals; Coordinated covalent bonds; Nanocomposites; Self-healing | Cellulose; Hydrogen Bonds; Ligands; Mixing; Monomers; Temperature; Cellulose; Ligands; Nanocomposites; Nanoparticles; Polymers; Temperature; Blending; Cellulose; Hydrogen bonds; Ligands; Monomers; Nanocrystals; Polymer matrix composites; Self-healing materials; Temperature; Tensile strength; Toughness; cellulose; ligand; nanocomposite; nanoparticle; polymer; Condition; Coordinated covalent bond; Highest temperature; Lows-temperatures; Mechanical; Metal ligands; Performance; Polymer-nanocomposite; Self-healing; Self-healing polymers; chemistry; temperature; Nanocomposites | English | 2022 | 2022-11-15 | 10.1016/j.carbpol.2022.119973 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Intelligent pH- and ammonia-sensitive indicator films using neutral red immobilized onto cellulose nanofibrils | In this study, colorimetric indicator films (CIFs) were developed by integrating neutral red covalently immobilized onto TEMPO-oxidized cellulose nanofibrils (NR@TOCNFs) and poly(acrylic acid) (PAA) inside a poly (vinyl alcohol) (PVA) matrix. The successful covalent immobilization of NR onto the TOCNFs was confirmed using attenuated total reflection-Fourier transform infrared, X-ray photoelectron spectroscopy, and thermogravimetric analyses. The CIFs had a visible color change from red to yellow as the pH changed from 2.0 to 10.0. The colorimetric response of CIFs improved as the NR@TOCNF content increased, while it decreased as the PAA level increased. The critical pH ranges for the color change of CIFs were 6-7, 7-8, and 8-9 for 3 %, 5 %, and 7 % PAA, respectively, at 0.3 % NR@TOCNF. The best ammonia sensitivity was found in the indicator films containing 3 % PAA and 0.3 % NR@TOCNF. These results showed that the CIFs could be applied for freshness detection in food packaging. | Khanjanzadeh, Hossein; Park, Byung-Dae; Pirayesh, Hamidreza | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea | ; Park, Byung-Dae/ABB-1934-2020; Khanjanzadeh, Hossein/B-7794-2018 | 37048874200; 7402834820; 37049319500 | byungdae@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 296 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2022 | 11.2 | 2.9 | 3.2 | 2025-06-25 | 35 | 35 | Neutral red; Immobilization; Colorimetric indicator film | COMPOSITE FILMS; BARRIER; SURFACE; ACID) | Colorimetric indicator film; Immobilization; Neutral red; TEMPO-oxidized cellulose nanofibril | Ammonia; Cellulose; Colorimetry; Esca; Gravimetry; Thermal Analysis; X Ray Spectroscopy; Ammonia; Cellulose; Food Packaging; Hydrogen-Ion Concentration; Neutral Red; Cellulose; Cellulose films; Color; Colorimetry; Infrared reflection; Nanofibers; Polyvinyl alcohols; Thermogravimetric analysis; X ray photoelectron spectroscopy; ammonia; cellulose; neutral red; Cellulose nanofibrils; Colorimetric indicator; Colorimetric indicator film; Immobilisation; Indicator films; Neutral Red; Oxidized cellulose; Poly(acrylic acid); Sensitive indicator; TEMPO-oxidized cellulose nanofibril; food packaging; pH; procedures; Ammonia | English | 2022 | 2022-11-15 | 10.1016/j.carbpol.2022.119910 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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