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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | Time-Trend of Metabolic Risks in Living Kidney Donors in South Korea | Kang, E.; Park, J.; Park, S.; Kim, Y.; Jeong, J.; An, J.; Lee, S.; Kim, S.; Cho, J.; Han, M.; Lee, H. | Seoul Natl Univ Hosp, Internal Med, Seoul, South Korea; Keimyung Univ Dongsan Hosp, Internal Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Internal Med, Seongnam, South Korea; Seoul Natl Univ, Boramae Med Ctr, Internal Med, Seoul, South Korea; Chonbuk Natl Univ Hosp, Internal Med, Jeonju, South Korea; Chonnam Natl Univ Hosp, Internal Med, Gwangju, South Korea; Kyungpook Natl Univ, Internal Med, Seoul, South Korea; Pusan Natl Univ Hosp, Internal Med, Pusan, South Korea | AMERICAN JOURNAL OF TRANSPLANTATION | AM J TRANSPLANT | 1600-6135 | 1600-6143 | 20 | SCIE | SURGERY;TRANSPLANTATION | 2020 | 8.086 | 2.6 | 0 | English | 2020 | 2020-04 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | Meeting Abstract | Urinary Exosomal Hemopexin, a Validated Diagnostic Marker for Rejection in Kidney Transplant Recipients | Lee, J.; Kim, J.; Lee, G.; Jeon, S.; Noh, H.; Lim, J.; Jung, H.; Choi, J.; Cho, J.; Park, S.; Kim, Y.; Kim, C. | Daegu Fatima Hosp, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Internal Med, Daegu, South Korea | Lee, Jeeyun/I-7171-2015 | AMERICAN JOURNAL OF TRANSPLANTATION | AM J TRANSPLANT | 1600-6135 | 1600-6143 | 20 | SCIE | SURGERY;TRANSPLANTATION | 2020 | 8.086 | 2.6 | 0 | English | 2020 | 2020-04 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | 6-Shogaol, an active ingredient of ginger, inhibits osteoclastogenesis and alveolar bone resorption in ligature-induced periodontitis in mice | Periodontitis is an inflammatory disease of the tissues surrounding teeth that causes destruction of connective tissues. During the progress of periodontitis, osteoclasts are solely accountable for the resorption of alveolar bones that leads to the loss of teeth if not properly treated. Thus, the development of effective anti-resorptive therapies will greatly benefit the treatment of periodontitis patients. In the present study, we suggest an inhibitory effect of 6-shogaol, an ingredient of ginger, on osteoclast differentiation and bone resorption. Mouse bone marrow cells were cultured in the presence of macrophage-colony stimulating factor and receptor activator of nuclear factor-kappa B ligand (RANKL) to investigate the effect of 6-shogaol on osteoclast differentiation and intracellular signaling pathways. 6-shogaol significantly reduced osteoclast differentiation, actin ring formation, and resorption. In the presence of 6-shogaol, osteoclast signaling including the RANKL-induced activation of mitogen-activated protein kinases, Ca2+ oscillation, generation of reactive oxygen species, and nuclear factor of activated T-cells, cytoplasmic 1 nuclear translocation was significantly inhibited in vitro. Furthermore, a ligature-induced periodontitis model in mice was used to determine the role of 6-shogaol in vivo. The administration of 6-shogaol prevented osteoclastogenesis and alveolar bone resorption induced by ligature. Furthermore, the ligature-induced number of macrophages and neutrophils as well as the expression of interleukin-1 beta and tumor necrosis factor-alpha were considerably lower in the periodontal tissues following shogaol injection. These results confirm the anti-osteoclastogenic effect of 6-shogaol and suggest the possibility of application as an anti-resorptive strategy in periodontitis. | Kim, Yong-Gun; Kim, Myoung Ok; Kim, Sung-Hyun; Kim, Hyo Jeong; Pokhrel, Nitin Kumar; Lee, Ji Hye; Lee, Heon-Jin; Kim, Jae-Young; Lee, Youngkyun | Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Biotechnol, Sangju, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, Daegu, South Korea; Pusan Natl Univ, Sch Dent, Dept Oral Pathol, Yangsan, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Microbiol, Daegu, South Korea | ; LEE, JIHYE/ABG-2265-2021 | 55622694400; 8934745900; 59103241900; 57203629899; 57193827745; 55689992200; 36462383000; 56812734700; 36062942200 | ylec@knu.ac.kr;ylee@knu.ac.kr; | JOURNAL OF PERIODONTOLOGY | J PERIODONTOL | 0022-3492 | 1943-3670 | 91 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 6.993 | 2.7 | 1.42 | 2025-06-25 | 27 | 28 | bone resorption; calcium; osteoclasts; periodontitis | FACTOR-KAPPA-B; RECEPTOR ACTIVATOR; OXIDATIVE STRESS; MECHANISMS; RANKL; DIFFERENTIATION; CONSTITUENT; EXPRESSION; INDUCTION; CYTOKINES | bone resorption; calcium; osteoclasts; periodontitis | Animals; Bone Resorption; Catechols; Cell Differentiation; Ginger; Humans; Mice; Osteoclasts; Osteogenesis; Periodontitis; RANK Ligand; cytokine; interleukin 1beta; osteoclast differentiation factor; reactive oxygen metabolite; shogaol; tumor necrosis factor; catechol derivative; shogaol; alveolar bone; animal experiment; animal model; animal tissue; Article; controlled study; drug effect; experimental periodontitis; fluorescence microscopy; gene expression; ginger; immunohistochemistry; macrophage; male; mouse; neutrophil; nonhuman; osteoclastogenesis; osteolysis; periodontitis; real time polymerase chain reaction; Western blotting; animal; bone development; cell differentiation; complication; human; osteoclast; periodontitis; prevention and control | English | 2020 | 2020-06 | 10.1002/jper.19-0228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Phase I dose-expansion (part II) study of ISU104 (a novel anti-ErbB3 monoclonal antibody) alone and combination with cetuximab (CET), in patients (pts) with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) | Kim, S-B.; Keam, B.; Shin, S.; Chae, Y. S.; Seo, S.; Park, K.; Kim, T. M.; Park, L. C.; Hong, S-B.; Lim, E.; Lee, S.; Ahn, M-J. | Asan Med Ctr, Dept Oncol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Kosin Univ Gospel Hosp, Dept Oncol Internal Med, Busan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Hematol Oncol, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr SMC, Dept Med, Seoul, South Korea; ISU Abxis Co Ltd, Drug Dev, Seongnam, South Korea; ISU Abxis Co Ltd, Clin Trial Team, Seongnam, South Korea | Park, Keunchil/ABD-5852-2021 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 31 | SCIE | ONCOLOGY | 2020 | 32.976 | 2.7 | 3 | English | 2020 | 2020-09 | 10.1016/j.annonc.2020.08.1043 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | Prospective, open-label, observational study of cetuximab for metastatic colorectal carcinoma (mCRC): The OPTIM1SE study | Yang, T-S.; Chen, H-H.; Bo-Wen, L.; Kim, T. W.; Chung, I. J.; Kim, J. G.; Ahn, J. B.; Lee, M. A.; Lin, J.; Ho, G. F.; Anh, L. T.; Temraz, S.; Burge, M.; Chua, C.; Huang, J.; Park, Y. S. | Chang Gung Mem Hosp, Dept Internal Med, Taipei, Taiwan; Chang Gung Mem Hosp Kaohsiung, Dept Surg, Div Colorectal Surg, Kaohsiung, Taiwan; Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Tainan, Taiwan; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Jeonnam, South Korea; Kyungpook Natl Univ, Med Ctr, Dept Oncol Hematol, Daegu, South Korea; Severance Hosp, Yonsei Canc Ctr, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Mackay Mem Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei, Taiwan; Univ Malaya, Med Ctr, Clin Oncol Unit, Kuala Lumpur, Malaysia; Cho Ray Hosp, Med Oncol, Ho Chi Minh City, Vietnam; Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon; Royal Brisbane Hosp, Dept Med Oncol, Brisbane, Qld, Australia; Natl Canc Ctr, Dept Med Oncol, Singapore, Singapore; Merck Pte Ltd, Oncol, Singapore, Singapore; Samsung Med Ctr, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea | Kim, Tae Won/GRX-7323-2022; HO, GWO FUANG/B-8634-2010 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 31 | SCIE | ONCOLOGY | 2020 | 32.976 | 2.7 | 0 | English | 2020 | 2020-11 | 10.1016/j.annonc.2020.10.125 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | South Korean real-world treatment patterns in patients with EGFRm NSCLC | Lee, J. C.; Kim, Y-C.; Lee, S. Y.; Yoo, S. S.; Davis, K.; Nagar, S. P.; Sawyer, W.; Yu, N.; Taylor, A. | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Chonnam Natl Univ, Sch Med, Hwasun Hosp, Lung Canc Clin,Pulm Med, Jeonnam, South Korea; Korea Univ, Guro Hosp, Pulmonol Allergy & Crit Care Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Lung Canc Ctr, Daegu, South Korea; RTI Hlth Solut, Hlth Econ Grp, Durham, NC USA; AstraZeneca, Biometr Oncol, Cambridge, England; AstraZeneca, Oncol Business Unit, Cambridge, England | Lee, Suk/AAH-4959-2021 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 31 | SCIE | ONCOLOGY | 2020 | 32.976 | 2.7 | 0 | English | 2020 | 2020-11 | 10.1016/j.annonc.2020.10.407 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Article | Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer | Objective To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target. Design FLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo models and molecular analyses, we characterised the fundamental biological roles of this lncRNA. We further explored the therapeutic potential of targeting FLANC in a mouse model of colorectal cancer (CRC) metastases. Results FLANC, a primate-specific lncRNA feebly expressed in normal colon cells, was significantly upregulated in cancer cells compared with normal colon samples in two independent cohorts. High levels of FLANC were associated with poor survival in two additional independent CRC patient cohorts. Both in vitro and in vivo experiments demonstrated that the modulation of FLANC expression influenced cellular growth, apoptosis, migration, angiogenesis and metastases formation ability of CRC cells. In vivo pharmacological targeting of FLANC by administration of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine nanoparticles loaded with a specific small interfering RNA, induced significant decrease in metastases, without evident tissue toxicity or pro-inflammatory effects. Mechanistically, FLANC upregulated and prolonged the half-life of phosphorylated STAT3, inducing the overexpression of VEGFA, a key regulator of angiogenesis. Conclusions Based on our findings, we discovered, FLANC as a novel primate-specific lncRNA that is highly upregulated in CRC cells and regulates metastases formation. Targeting primate-specific transcripts such as FLANC may represent a novel and low toxic therapeutic strategy for the treatment of patients. | Pichler, Martin; Rodriguez-Aguayo, Cristian; Nam, Su Youn; Dragomir, Mihnea Paul; Bayraktar, Recep; Anfossi, Simone; Knutsen, Erik; Ivan, Cristina; Fuentes-Mattei, Enrique; Lee, Sang Kil; Ling, Hui; Catela Ivkovic, Tina; Huang, Guoliang; Huang, Li; Okugawa, Yoshinaga; Katayama, Hiroyuki; Taguchi, Ayumu; Bayraktar, Emine; Bhattacharya, Rajat; Amero, Paola; He, William Ruixian; Tran, Anh M.; Vychytilova-Faltejskova, Petra; Klec, Christiane; Bonilla, Diana L.; Zhang, Xinna; Kapitanovic, Sanja; Loncar, Bozo; Gafa, Roberta; Wang, Zhihui; Cristini, Vittorio; Hanash, Samir M.; Bar-Eli, Menashe; Lanza, Giovanni; Slaby, Ondrej; Goel, Ajay; Rigoutsos, Isidore; Lopez-Berestein, Gabriel; Calin, George Adrian | Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA; Med Univ Graz, Div Oncol, Graz, Austria; Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA; Kyungpook Natl Univ Hosp, Gastroenterol Dept, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; UiT Arctic Univ Norway, Fac Hlth Sci, Dept Med Biol, Tromso, Norway; Yonsei Univ, Coll Med, Inst Gastroenterol, Dept Internal Med, Seoul, South Korea; Rudjer Boskovic Inst, Div Mol Med, Zagreb, Croatia; Guangdong Med Univ, Dongguan Sci Res Ctr, China Amer Canc Res Inst, Dongguan, Peoples R China; Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA; Baylor Univ, Med Ctr, Baylor Scott & White Hlth Res Inst, Ctr Gastrointestinal Res, Dallas, TX USA; Baylor Univ, Med Ctr, Baylor Scott & White Hlth Res Inst, Ctr Translat Genom & Oncol, Dallas, TX USA; Baylor Univ, Med Ctr, Charles A Sammons Canc Ctr, Dallas, TX USA; Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA; Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic; Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic; Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Houston, TX 77030 USA; Indiana Univ, Med & Mol Genet Dept, Indianapolis, IN 46204 USA; Dubrava Clin Hosp, Dept Surg, Zagreb, Croatia; Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Emilia Romagna, Italy; Houston Methodist Res Inst, Math Med Program, Houston, TX USA; Univ Ferrara, Dept Med Sci, Ferrara, Emilia Romagna, Italy; City Hope Natl Med Ctr, Dept Mol Diagnost Therapeut & Translat Oncol, 1500 E Duarte Rd, Duarte, CA 91010 USA; Thomas Jefferson Univ, Computat Med Ctr, Philadelphia, PA 19107 USA; Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA | Slaby, Ondrej/E-1082-2012; Cristini, Vittorio/N-3540-2013; Gafa', Roberta/K-6339-2016; Knutsen, Erik/ABH-6287-2020; Kim, Joo/JAZ-0897-2023; Ivkovic, Tina/AAL-1324-2020; Huang, Lihaoyun/MAH-9678-2025; Vychytilova, Petra/E-2805-2012; Goel, Ajay/ADO-9623-2022; LANZA, GIOVANNI/K-6635-2016; ANFOSSI, simone/AEO-1609-2022; Dragomir, Mihnea/ABB-8207-2020; Huang, Guoliang/H-1625-2011; Rigoutsos, Isidore/C-5381-2012; Calin, George/E-9390-2011; Taguchi, Ayumu/N-7396-2019; Xinna, Zhang/HTT-1251-2023; Lanza, Giovanni/K-6635-2016 | 56873185600; 35734770500; 55617028500; 57190609894; 37036763600; 6506414764; 55875389500; 36628618800; 35317342400; 49963940700; 54410980800; 54896423700; 55534423500; 55487326100; 22136272200; 36113833200; 7102943852; 56051682000; 55414844100; 37111834900; 57210926238; 57201575211; 56604214700; 56682032200; 24464006000; 35075402200; 26643129600; 25029775000; 6601964907; 55719821000; 55383716500; 35352731300; 7005368036; 7102249555; 23487229700; 7201830179; 7004361944; 7005537037; 7004623029 | glopez@mdanderson.org;gcalin@mdanderson.org; | GUT | GUT | 0017-5749 | 1468-3288 | 69 | 10 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 23.059 | 2.7 | 6.04 | 2025-06-25 | 80 | 84 | colorectal cancer; oncogenes; molecular genetics; gene therapy; angiogenesis | VEGF; EXPRESSION; DISCOVERY; BIOMARKER; MICRORNA; STAT3; MODEL; WNT | angiogenesis; colorectal cancer; gene therapy; molecular genetics; oncogenes | Animals; Biomarkers, Tumor; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Drug Discovery; Gene Expression Regulation, Neoplastic; Genetic Markers; Genetic Therapy; Humans; Mice; Neovascularization, Pathologic; Pharmacogenomic Testing; RNA, Long Noncoding; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A; dioleoylphosphatidylcholine; long untranslated RNA; long untranslated RNA FLANC; small interfering RNA; STAT3 protein; unclassified drug; vasculotropin A; long untranslated RNA; STAT3 protein; tumor marker; vasculotropin A; aged; angiogenesis; animal experiment; animal model; animal tissue; apoptosis; Article; cancer survival; cell growth; cell migration; cohort analysis; colorectal cancer; controlled study; correlational study; female; gene expression; gene function; gene location; gene targeting; genetic correlation; human; in vitro study; in vivo study; major clinical study; male; metastatic colon cancer; mouse; nonhuman; priority journal; protein phosphorylation; upregulation; animal; carcinogenesis; cell proliferation; colorectal tumor; drug development; drug effect; gene expression regulation; gene therapy; genetic marker; genetics; metabolism; neovascularization (pathology); pharmacogenetic testing | English | 2020 | 2020-10 | 10.1136/gutjnl-2019-318903 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor β-induced protein and improves survival in sepsis | Sepsis is a potentially fatal complication of infections and there are currently no effective therapeutic options for severe sepsis. In this study, we revealed the secretion mechanism of transforming growth factor beta-induced protein (TGFBIp) that was recently identified as a therapeutic target for sepsis, and designed TGFBIp acetylation inhibitory peptide (TAIP) that suppresses acetylation of lysine 676 in TGFBIp. To improve bioavailability and biodegradation of the peptide, TAIP was conjugated to polyamidoamine (PAMAM) dendrimers. Additionally, the cell-penetrating peptide (CPP) was conjugated to the TAIP-modified PAMAM dendrimers for the intracellular delivery of TGFBIp. The resulting nanostructures, decorated with TAIP and CPP via poly(ethylene glycol) linkage, improved the mortality and organ damage in the septic mouse model and suppressed lipopolysaccharide-activated severe vascular inflammatory responses in endothelial cells. Thus, the dendrimer-based nanostructures for delivery of TAIP using CPP show great promise in practical applications in sepsis therapy. | Lee, Wonhwa; Park, Eun Ji; Kwon, Oh Kwang; Kim, Hyelim; Yoo, Youngbum; Kim, Shin-Woo; Seo, Young-Kyo; Kim, In-San; Na, Dong Hee; Bae, Jong-Sup | Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Res Inst Pharmaceut Sci, CMRI,Coll Pharm, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea; Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; D&D Pharmatech, Seongnam 13486, Gyeonggi Do, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Seoul 02792, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea | ; Bae, Jong-Sup/AAU-9724-2020; Seo, Young-kyo/AFF-4104-2022; Lee, Wonhwa/GLQ-6506-2022 | 50161632800; 57760110400; 55579791200; 57210146478; 57204017274; 8710731500; 24465975600; 34770432800; 7103210503; 16021543200 | Wonhwalee@kribb.re.kr;ejpark@ddpharmatech.com;dhna@cau.ac.kr;baejs@knu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 246 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 12.479 | 2.8 | 0.73 | 2025-06-25 | 13 | 15 | Sepsis; Transforming growth factor beta-induced protein; Acetylation inhibitory peptide; Dendrimer; Nanodrug delivery | ORGAN FAILURE; PATHOPHYSIOLOGY; DYSFUNCTION; BETA-IG-H3; MOLECULE; ADHESION; DELIVERY; PROGRESS | Acetylation inhibitory peptide; Dendrimer; Nanodrug delivery; Sepsis; Transforming growth factor β-induced protein | Acetylation; Animals; Dendrimers; Extracellular Matrix Proteins; Human Umbilical Vein Endothelial Cells; Mice; Mice, Inbred C57BL; Sepsis; Transforming Growth Factor beta; Acetylation; Amino acids; Biochemistry; Biodegradation; Endothelial cells; Nanostructures; Peptides; Polyethylene glycols; alanine aminotransferase; alanylpropylvalyltyrosylglutaminyllysylleucylleucylglutamylarginine; antiinfective agent; antiinflammatory agent; aspartate aminotransferase; cell penetrating peptide; complementary DNA; creatinine; dendrimer; histone acetyltransferase PCAF; interleukin 6; lactate dehydrogenase; macrogol; monocyte chemotactic protein 1; polyamidoamine; protein inhibitor; transforming growth factor beta; tumor necrosis factor; unclassified drug; dendrimer; scleroprotein; transforming growth factor beta; Cell-penetrating peptide; Induced proteins; Inhibitory peptides; Intracellular delivery; Nanodrug delivery; Polyamidoamine dendrimers; Sepsis; Transforming growth factor beta; alanine aminotransferase blood level; amino acid substitution; animal experiment; animal model; antiinflammatory activity; antimicrobial activity; Article; aspartate aminotransferase blood level; binding affinity; cell viability; controlled study; creatinine blood level; cytokine release; disease severity; drug bioavailability; drug conjugation; drug degradation; drug delivery system; drug potency; drug protein binding; drug stability; drug synthesis; drug targeting; endothelium cell; gene expression; human; hydrophobicity; in vitro study; in vivo study; lactate dehydrogenase blood level; male; mouse; mRNA expression level; nonhuman; priority journal; protein acetylation; protein blood level; protein expression; sepsis; upregulation; urea nitrogen blood level; acetylation; animal; C57BL mouse; metabolism; umbilical vein endothelial cell; Dendrimers | English | 2020 | 2020-07 | 10.1016/j.biomaterials.2020.120000 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fabrication and characterization of pullulan-based nanocomposites reinforced with montmorillonite and tempo cellulose nanofibril | Nanocomposite film of pullulan (PULL), tempo cellulose nanofibrils (TOCNs) and, montmorillonite clay (MMT) were prepared using a solution casting method with aqueous solutions. X-ray diffraction data revealed that exfoliated MMT nanoplatelets are distributed within the PULL/TOCNs/MMT film structure. Fourier-transform infrared results revealed that there might be interactions among the TOCNs, MMT and PULL matrix led to improved tensile strength, thermal stability, water barrier properties, and decrease moisture susceptibility while maintained reasonable transparency and biodegradability of the ternary PULL nanocomposites. These excellent properties of the nanocomposites clearly indicate towards a new strategy for developing high-performance PULL-based nanocomposites by using two different types of fillers with various geometric shapes and aspect ratio. This kind of ternary nanocomposite film can be broadly used in food packaging and protection as a green and biodegradable film. | Yeasmin, Sabina; Yeum, Jeong Hyun; Yang, Seong Baek | Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea | Yang, Seong/AAP-1745-2020 | 57216565706; 6602257098; 56258526300 | jhyeum@knu.ac.kr;ysb@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 240 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2020 | 9.381 | 2.8 | 2.34 | 2025-06-25 | 38 | 42 | Pullulan; Tempo cellulose nanofibrils; Montmorillonite; Nanocomposite film; Thermal and mechanical properties; Biodegradability | PROPERTY CHARACTERIZATION; MEDIATED OXIDATION; PROTEIN; FILMS; CLAY; MICROFIBRILS; COMPOSITES; BIOPOLYMER; POLYMERS; FIBRILS | Biodegradability; Montmorillonite; Nanocomposite film; Pullulan; Tempo cellulose nanofibrils; Thermal and mechanical properties | Biodegradability; Cellulose; Clay; Film; Montmorillonite; Pullulan; Tensile Strength; Transparence; Bentonite; Biodegradation, Environmental; Cellulose; Cyclic N-Oxides; Food Packaging; Glucans; Nanocomposites; Nanofibers; Soil Microbiology; Tensile Strength; Water; Aspect ratio; Biodegradability; Cellulose; Cellulose nanocrystals; Clay minerals; Nanocomposites; Nanofibers; Tensile strength; amine oxide; bentonite; cellulose; glucan; nanocomposite; nanofiber; pullulan; TEMPO; water; Cellulose nanofibrils; Fabrication and characterizations; Fourier transform infra reds; Moisture susceptibility; Solution-casting method; Ternary nanocomposites; Water barrier properties; X-ray diffraction data; bioremediation; chemistry; food packaging; metabolism; microbiology; tensile strength; Nanocomposite films | English | 2020 | 2020-07-15 | 10.1016/j.carbpol.2020.116307 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Highly brain-permeable apoferritin nanocage with high dysprosium loading capacity as a new T2 contrast agent for ultra-high field magnetic resonance imaging | High sensitivity at ultra-high field (UHF) and sufficient potential to penetrate the brain are the most desirable characteristics in the development of contrast agents (CAs) for magnetic resonance imaging (MRI). However, incorporating such qualifies into a single nanocarrier is challenging. Herein, we report a new strategy for a highly brain-permeable MR CA with high sensitivity at UHF by loading dysprosium chelates (DyL) in apoferritin cavities (Apo-DyL). We also design the chelate ligand structure to increase DyL loading capacity within the apoferritin cavity. Using the intracerebroventricular (ICV) injection approach as a new delivery route for ApoDyL, we demonstrate that apoferritin loaded with DyL can penetrate the brain-ventricular barrier and diffuse into the brain. This brain-permeable capability is unique to Apo-DyL, compared with other types of nanoparticles used in MRI. Apo-DyL also shows significant increase in MR sensitivity of DyL at UHF. Furthermore, based on brain tumor imaging at UHF, Apo-DyL can significantly enhance the tumor for a lower dose of the CA than the previously reported Gd- or Mn-loaded apoferritin nanoplatform. Therefore, Apo-DyL can be a novel nanoplatform that is a highly sensitive and versatile MR CA for UHF brain imaging. | Kim, Hee-Kyung; Baek, Ah Rum; Choi, Garam; Lee, Jung-jin; Yang, Ji-ung; Jung, Hoesu; Lee, Taekwan; Kim, Dongkyu; Kim, Minsup; Cho, Art E.; Lee, Gang Ho; Chang, Yongmin | Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea; Myungmoon Bio Co, Dept R&D Ctr, Hwaseong, Gyeonggi Do, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu, South Korea; Korea Univ, Dept Bioinformat, Sejong, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea | Choi, Garam/NHP-2919-2025; Lee, Jungjin/HZL-2693-2023; Kim, Dong/AEG-4375-2022 | 56014729400; 57194601711; 56013903700; 10143410400; 57212217968; 58728242200; 55501335000; 57779034700; 56122945800; 8586262300; 7404851841; 7501840633 | ychang@knu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 243 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 12.479 | 2.8 | 0.6 | 2025-06-25 | 15 | 15 | Apoferritin; Dysprosium chelates; Brain; Ultra-high field MRI | NUCLEAR-RELAXATION; LOADED APOFERRITIN; MRI; NANOPARTICLES; FERRITIN; BARRIER; DEPENDENCE; COMPLEXES; DIFFUSION; SYSTEMS | Apoferritin; Brain; Dysprosium chelates; Ultra-high field MRI | Apoferritins; Brain; Contrast Media; Dysprosium; Magnetic Resonance Imaging; Brain; Brain mapping; Chelation; Dysprosium; Dysprosium compounds; Magnetic resonance imaging; Tumors; apoferritin; chelate; dysprosium; gadolinium; manganese; nanocage; nanoparticle; nuclear magnetic resonance imaging agent; apoferritin; contrast medium; dysprosium; Apoferritin; Brain tumor imaging; Chelate ligands; High sensitivity; Loading capacities; Ultra high field magnetic resonance imaging; Ultra-high field mris; Ultra-high fields; Article; brain; brain tumor; drug diffusion; drug dosage form comparison; drug penetration; drug structure; intermethod comparison; intracerebroventricular drug administration; nuclear magnetic resonance imaging; priority journal; ultra high field magnetic resonance imaging; brain; diagnostic imaging; nuclear magnetic resonance imaging; Loading | English | 2020 | 2020-06 | 10.1016/j.biomaterials.2020.119939 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Lipid-based nanodelivery approaches for dopamine-replacement therapies in Parkinson's disease: From preclinical to translational studies | The incidence of Parkinson's disease (PD), the second most common neurodegenerative disorder, has increased exponentially as the global population continues to age. Although the etiological factors contributing to PD remain uncertain, its average incidence rate is reported to be 1% of the global population older than 60 years. PD is primarily characterized by the progressive loss of dopaminergic (DAergic) neurons and/or associated neuronal networks and the subsequent depletion of dopamine (DA) levels in the brain. Thus, DA or levodopa (L-dopa), a precursor of DA, represent cardinal targets for both idiopathic and symptomatic PD therapeutics. While several therapeutic strategies have been investigated over the past decade for their abilities to curb the progression of PD, an effective cure for PD is currently unavailable. Even DA replacement therapy, an effective PD therapeutic strategy that provides an exogenous supply of DA or L-dopa, has been hindered by severe challenges, such as a poor capacity to bypass the blood brain barrier and inadequate bioavailability. Nevertheless, with recent advances in nanotechnology, several drug delivery systems have been developed to bypass the barriers associated with central nervous system therapeutics. In here, we sought to describe the adapted lipid-based nanodrug delivery systems used in the field of PD therapeutics and their recent advances, with a particular focus placed on DA replacement therapies. This work initially explores the background of PD; offers descriptions of the most recent molecular targets; currently available clinical medications/limitations; an overview of several lipid-based PD nanotherapeutics, functionalized nanoparticles, and technical aspects in brain delivery; and, finally, presents future perspectives to enhance the use of nanotherapeutics in PD treatment. | Karthivashan, Govindarajan; Ganesan, Palanivel; Park, Shin-Young; Lee, Ho-Won; Choi, Dong-Kug | Konkuk Univ, Coll Biomed & Hlth Sci, Dept Biotechnol, Chungju 27478, South Korea; Kyungpook Natl Univ, Dept Neurol, Sch Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41404, South Korea; Konkuk Univ, Coll Biomed & Hlth Sci, Res Inst Inflammatory Dis RID, Chungju 27478, South Korea; Konkuk Univ, BK21plus Glocal Educ Program Nutraceut Dev, Chungju 27478, South Korea; Konkuk Univ, Coll Biomed & Hlth Sci, Dept Appl Life Sci, Dept Biomed Chem,Nanotechnol Res Ctr, Chungju 27478, South Korea | 55829418800; 41861350800; 56737295900; 35337240700; 7401643837 | choidk@kku.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 232 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 12.479 | 2.8 | 0.44 | 2025-06-25 | 31 | 35 | Parkinson's disease; Dopamine/levodopa; Blood-brain barrier; Nanodrug delivery; Lipid-based nanoparticles | BLOOD-BRAIN-BARRIER; LEVODOPA-INDUCED DYSKINESIA; POLYMER HYBRID NANOPARTICLES; AMANTADINE EXTENDED-RELEASE; MITOCHONDRIAL COMPLEX-I; DRUG-DELIVERY SYSTEMS; QUALITY-OF-LIFE; BASAL GANGLIA; ALPHA-SYNUCLEIN; NONMOTOR SYMPTOMS | Blood–brain barrier; Dopamine/levodopa; Lipid-based nanoparticles; Nanodrug delivery; Parkinson's disease | Dopamine; Dopamine Agents; Dopaminergic Neurons; Humans; Levodopa; Lipids; Parkinson Disease; Amines; Biochemistry; Blood; Controlled drug delivery; Disease control; Nanoparticles; Neural networks; Neurodegenerative diseases; Neurons; dopamine; drug carrier; levodopa; lipid polymer hybrid; liposome; nanostructured lipid carrier; neurotransmitter; solid lipid nanoparticle; unclassified drug; dopamine; dopamine receptor stimulating agent; levodopa; lipid; Central nervous systems; Dopamine/levodopa; Drug delivery system; Functionalized nanoparticles; Nanodrug delivery; Neurodegenerative disorders; Parkinson's disease; Therapeutic strategy; blood brain barrier; disease exacerbation; dopaminergic nerve cell; drug delivery system; drug mechanism; environmental factor; heredity; human; mitochondrion; molecularly targeted therapy; nanotechnology; nervous system inflammation; nigroneostriatal system; nonhuman; oxidative stress; Parkinson disease; pathogenesis; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); priority journal; protein aggregation; protein misfolding; Review; signal transduction; substitution therapy; Parkinson disease; Targeted drug delivery | English | 2020 | 2020-02 | 10.1016/j.biomaterials.2019.119704 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nonwoven rGO Fiber-Aramid Separator for High-Speed Charging and Discharging of Li Metal Anode | Li metal, which has a high theoretical specific capacity and low redox potential, is considered to the most promising anode material for next-generation Li ion-based batteries. However, it also exhibits a disadvantageous solid electrolyte interphase (SEI) layer problem that needs to be resolved. Herein, an advanced separator composed of reduced graphene oxide fiber attached to aramid paper (rGOF-A) is introduced. When rGOF-A is applied, F- anions, generated from the decomposition of the LiPF6 electrolyte during the SEI layer formation process form semi-ionic C-F bonds along the surface of rGOF. As Li+ ions are plated, the "F-doped" rGO surface induces the formation of LiF, which is known as a component of a chemically stable SEI, therefore it helps the Li metal anode to operate stably at a high current of 20 mA cm(-2) with a high capacity of 20 mAh cm(-2). The proposed rGOF-A separator successfully achieves a stable SEI layer that could resolve the interfacial issues of the Li metal anode. | Gong, Yong Jun; Heo, Jung Woon; Lee, Hakji; Kim, Hyunjin; Cho, Jinil; Pyo, Seonmi; Yun, Heejun; Kim, Heebae; Park, Sang Yoon; Yoo, Jeeyoung; Kim, Youn Sang | Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Gwanak Ro 1, Seoul 08826, South Korea; Adv Inst Convergence Technol, Gwanggyo Ro 145, Suwon 16229, South Korea; Korea Res Inst Chem Technol, 141 Gajeong Ro, Daejeon 34114, South Korea; Kyungpook Natl Univ, Dept Sch Energy Engn, Daehak Ro 80, Daegu 41566, South Korea; Seoul Natl Univ, Coll Engn, Sch Chem & Biol Engn, Gwanak Ro 1, Seoul 08826, South Korea | ; Yoo, Jeeyoung/AAH-1359-2019; Cho, Hyuk/AAU-7753-2020; Kim, SoW/ABB-7917-2021 | 57203432769; 57218203259; 57218199857; 59564809200; 57209801309; 57211858131; 57218197755; 57217054648; 57190687481; 56046607500; 8938854200 | yoonpark77@snu.ac.kr;jyoo@knu.ac.kr;younskim@snu.ac.kr; | ADVANCED ENERGY MATERIALS | ADV ENERGY MATER | 1614-6832 | 1614-6840 | 10 | 27 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 29.368 | 2.8 | 1.87 | 2025-06-25 | 64 | 61 | functional separators; Li metal anodes; Li metal batteries; reduced graphene oxide; SEI layers; solid electrolyte interphase | LITHIUM-METAL; FLUORINATED GRAPHENE; HIGH-CAPACITY; HIGH-ENERGY; ELECTROLYTE; BATTERIES; INTERFACES; REDUCTION; BEHAVIOR; DENSITY | functional separators; Li metal anodes; Li metal batteries; reduced graphene oxide; SEI layers; solid electrolyte interphase | Anodes; Aramid fibers; Charging (batteries); Graphene; Ions; Lithium; Lithium-ion batteries; Redox reactions; Reduced Graphene Oxide; Seebeck effect; Separators; Solid electrolytes; Anode material; Aramid paper; High capacity; High currents; Layer formation; Redox potentials; Solid electrolyte interphase layer (SEI); Specific capacities; Lithium compounds | English | 2020 | 2020-07 | 10.1002/aenm.202001479 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Phage display-identified PD-L1-binding peptides reinvigorate T-cell activity and inhibit tumor progression | Blockade of programmed cell death ligand-1 (PD-L1) restores T-cell activity and enhances anti-tumor immunity. Screening a phage-displayed peptide library for peptides that selectively bind to PD-L1-overexpressing cells identified two peptides, CLQKTPKQC and CVRARTR (PD-L1Pep-1 and PD-L1Pep-2, respectively) that appeared to block PD-L1. PD-L1 Pep-1 and PD-L1 Pep-2 preferentially bound to high PD-L1 -expressing cells over low PD-L1-expressing cells; binding was further enhanced by interferon-gamma, an inducer of PD-L1 expression. Binding affinities of PD-L1 Pep-1 and PD-L1 Pep-2 were approximately 373 and 281 nM, respectively. Cellular binding of the PD-L1-binding peptides was reduced by silencing PD-Ll gene expression or competition with anti-PD-Ll antibody. PD-L1 Pep-1 and PD-L1 Pep-2 induced the internalization and downregulated cell surface levels of PD-Ll. The PD-L1-binding peptides restored cytokine secretion and T-cell proliferation to cells inhibited by co-culture with tumor cells or culture on PD-L1-coated plates. Intravenously injected PD-L1 Pep-1 and PD-L1 Pep-2 efficiently homed to tumor tissues, inhibited tumor growth, and increased CD8 + /FoxP3 + ratio in mice. The PD-Ll -binding peptides in combination with doxorubicin or PD-Ll -targeted liposomal doxorubicin inhibited tumor growth and increased CD8 + /FoxP3 + ratio more efficiently than doxorubicin alone and untargeted liposomal doxorubicin, respectively. These results suggest that PD-L1Pep-1 and PD-L1 Pep-2 block PD-Ll and reinvigorate T-cell activity, inhibiting tumor growth by enhancing anti-tumor immunity. | Gurung, Smriti; Khan, Fatima; Gunassekaran, Gowri Rangaswamy; Do Yoo, Jae; Vadevoo, Sri Murugan Poongkavithai; Permpoon, Uttapol; Kim, Sang-Hyun; Kim, Ha-Jeong; Kim, In-San; Han, Hyeonjeong; Park, Ji-Ho; Kim, Soyoun; Lee, Byungheon | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Korea Inst Sci & Technol, Biomed Ctr, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea; Korea Univ, KU KIST Sch, 145 Anam Ro, Seoul 02841, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Dept Bio & Brain Engn, 291 Daehak Ro, Daejeon 34141, South Korea | ; Khan, Fatima/GQP-2552-2022 | 57205752137; 57205752395; 36028043400; 57216203097; 57216201305; 57205752273; 57210450420; 57191717512; 34770432800; 57216203689; 56900155700; 58847992000; 16304374900 | leebh@knu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 247 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 12.479 | 2.8 | 2.46 | 2025-06-25 | 61 | 59 | Immune checkpoint blockade; PD-1; PD-L1; Peptides; Phage display; T-cell activity | PD-1/PD-L1 INTERACTION; ANTI-PD-L1 ANTIBODY; DEATH 1; CANCER; PD-1; EXPRESSION; BLOCKADE; BLOCKING | Immune checkpoint blockade; PD-1; PD-L1; Peptides; Phage display; T-cell activity | Animals; B7-H1 Antigen; Bacteriophages; Cell Line, Tumor; Mice; Peptides; T-Lymphocytes; Binding energy; Cell death; Cell membranes; Cell proliferation; Diagnosis; Gene expression; Mammals; Peptides; Phage display; Restoration; Tumors; antineoplastic agent; CD8 antigen; cysteinylleucinylglutaminyllysinylthreoninylprolinyllysinylglutaminylcysteine; cysteinylvalinylargininylalaninylargininylthreoninylarginine; doxorubicin; liposome; programmed death 1 ligand 1; programmed death 1 ligand 1 antibody; protein antibody; recombinant programmed death 1 ligand 1; recombinant protein; transcription factor FOXP3; unclassified drug; peptide; programmed death 1 ligand 1; Binding affinities; Cell activity; Cytokine secretions; Immune checkpoint blockade; Liposomal doxorubicin; Phage displayed peptide; Programmed cell deaths; Tumor progressions; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast carcinoma; cancer immunotherapy; cancer inhibition; cancer tissue; cell activity; cell proliferation; coculture; controlled study; cytokine release; drug binding; female; human; human cell; MCF-7 cell line; MDA-MB-231 cell line; mouse; nonhuman; priority journal; T lymphocyte; tumor growth; animal; bacteriophage; T lymphocyte; tumor cell line; T-cells | English | 2020 | 2020-07 | 10.1016/j.biomaterials.2020.119984 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Regulating the Catalytic Dynamics Through a Crystal Structure Modulation of Bimetallic Catalyst | The surface of solid catalysts is one of the most important factors where the interface with reaction products governs the reaction kinetics. Herein, the crystal phase of palladium-copper nanoparticles (PdCu NPs) is controlled to modulate their surface atomic arrangement, which will govern the growth dynamics of discharge products on their surfaces and thus the catalytic performances in non-aqueous lithium-oxygen (Li-O-2) batteries. First-principles calculations and experimental validations reveal that homogeneous nucleation and distribution of discharge products are observed on the surface of body-centered cubic PdCu NPs, promoting the oxygen reduction/evolution reaction (ORR/OER) activities in Li-O-2 batteries. However, the agglomerates formed on the surface of its face-centered cubic homologue deteriorates ORR/OER activities, which worsen the battery performances. For the first time, this work theoretically and experimentally demonstrates how the crystal phase modulation regulates the nucleation behaviors and growth dynamics of discharge products for ORR/OER. | Park, Mihui; Liang, Chaoping; Lee, Tae Hyung; Agyeman, Daniel Adjei; Yang, Junghoon; Lau, Vincent Wing-hei; Choi, Sang-Il; Jang, Ho Won; Cho, Kyeongjae; Kang, Yong-Mook | Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea; Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75080 USA; Cent South Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China; Seoul Natl Univ, Res Inst Adv Mat, Dept Mat Sci & Engn, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea | Lee, Tae-Hyung/I-2065-2014; Kang, Yong-Mook/G-9132-2016; Jang, Ho/D-9866-2011; Lau, Vincent Wing-hei/S-4709-2017; Liang, Chaoping/K-9706-2016; Jang, Ho Won/D-9866-2011; Lau, Vincent/S-4709-2017; Choi, Sang-Il/AGR-1133-2022; Cho, Kyeongjae/ACL-9833-2022 | 56239343400; 56661585400; 57192164205; 56523161100; 57218299505; 55801753300; 56167600800; 7202135252; 37042877400; 7402784330 | kjcho@utdallas.edu;dake1234@korea.ac.kr; | ADVANCED ENERGY MATERIALS | ADV ENERGY MATER | 1614-6832 | 1614-6840 | 10 | 8 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 29.368 | 2.8 | 0.91 | 2025-06-25 | 37 | 35 | crystal structure modulation; first-principles calculation; growth dynamics; lithium-oxygen batteries; PdCu nanoparticles | LI-O-2 BATTERIES; ELECTROCATALYSTS | crystal structure modulation; first-principles calculation; growth dynamics; lithium–oxygen batteries; PdCu nanoparticles | Binary alloys; Calculations; Catalysts; Copper alloys; Dynamics; Electrolytic reduction; Lithium compounds; Lithium-air batteries; Modulation; Nanoparticles; Nucleation; Oxygen; Palladium alloys; Reaction kinetics; Catalytic performance; Experimental validations; First-principles calculation; Growth dynamics; Homogeneous nucleation; Oxygen reduction/evolution; Structure modulation; Surface atomic arrangements; Crystal structure | English | 2020 | 2020-02 | 10.1002/aenm.201903225 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ultrahigh Power Output from Triboelectric Nanogenerator Based on Serrated Electrode via Spark Discharge | An ultrahigh power output from a triboelectric nanogenerator (TENG) with a serrated electrode in a low-frequency contact-separation mode which is able to directly drive high voltage-operating devices without the need for an external power supply is demonstrated. When a serrated electrode-based TENG (SE-TENG) is driven, the microstructurally serrated electrode creates a spark discharge in the gap between the serrated electrode and a wire, resulting in tremendously boosted triboelectric power output. Based on the spark discharge phenomenon, a boost adaptor is designed to secondarily boost the triboelectric power output performance, and consequently an ultrahigh triboelectric output voltage of 5 kV and current density of 2 A m(-2)are achieved. The boost adaptor concept can be applied to any typical TENG for achieving higher power-generating performance. Finally, two high voltage applications, a Crookes tube and plasma generation, are demonstrated using the SE-TENG and boost adaptor without any external power supply equipment. The ultrahigh power-generating SE-TENG based on the spark discharge phenomenon occurring in the unique electrode structure has considerable potential to operate high voltage applications directly in harsh environments where electricity cannot be supplied. | Kim, Jihye; Cho, Hanchul; Han, Maeum; Jung, Young; Kwak, Sung Soo; Yoon, Hong-Joon; Park, Byunggeon; Kim, Hyeok; Kim, Hyoungjae; Park, Jinhyoung; Kim, Sang-Woo | Sungkyunkwan Univ SKKU, Sch Adv Mat Sci & Engn, Suwon 16419, South Korea; Korea Inst Ind Technol KITECH, Precis Mech Proc & Control R&D Grp, Busan 46938, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Pusan Natl Univ, Grad Sch Mech Engn, Busan 46241, South Korea; Univ Seoul, Dept Elect & Comp Engn, Seoul 02504, South Korea; Korea Univ Technol & Educ, Sch Mechatron Engn, Cheonan 31253, South Korea; Sungkyunkwan Univ SKKU, Samsung Adv Inst Hlth Sci & Technol SAIHST, SKKU Adv Inst Nanotechnol SAINT, Suwon 16419, South Korea | Kim, Sang-Woo/I-7769-2014; Kim, Jihye/AAC-6090-2019; Yoon, Hong-Joon/HOH-1559-2023; Yoon, Hong-Joon/F-9085-2019 | 57226166179; 24398481500; 55931924500; 57198682130; 56883863300; 56594141900; 57203461786; 57191718658; 57260996500; 57225161884; 55133788700 | jhpark98@koreatech.ac.kr;kimsw1@skku.edu; | ADVANCED ENERGY MATERIALS | ADV ENERGY MATER | 1614-6832 | 1614-6840 | 10 | 44 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 29.368 | 2.8 | 2.06 | 2025-06-25 | 52 | 60 | self-powered high voltage applications; serrated electrodes; spark discharge; triboelectric nanogenerators; ultrahigh power output | STABLE HYDROPHILIC SURFACES; PLASMA; LAYER; PDMS | self-powered high voltage applications; serrated electrodes; spark discharge; triboelectric nanogenerators; ultrahigh power output | Electric discharges; Electric power supplies to apparatus; Electric power systems; Electrodes; Nanotechnology; Thermoelectric power; Triboelectricity; Contact separation; Electrode structure; External power supplies; Harsh environment; High voltage applications; Operating devices; Output voltages; Plasma generation; Nanogenerators | English | 2020 | 2020-11 | 10.1002/aenm.202002312 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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