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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Associations of Body Mass Index and Lifestyle Factors with Suicidal Ideation, Planning, and Attempts Among Korean Adolescents: A Cross-Sectional Study | Background: Unhealthy lifestyles constitute significant risk factors for adolescent suicide, and their detrimental effects may persist from adolescence into adulthood. This research study sought to examine how Body Mass Index (BMI), alongside various lifestyle behaviors among teenagers in Korea, correlates with suicidal thoughts, the formulation of suicide plans, and actual suicide attempts. Methods: The research examined unprocessed information collected during the 2022 Korean Youth Risk Behavior Web-based Survey (KYRBS), which was administered by the Korea Disease Control and Prevention Agency (KDCA). Lifestyle factors associated with suicidal behavior were selected as independent variables. The sample was stratified according to BMI for further analysis. Logistic regression models were applied to assess the association between lifestyle factors and the risk of adolescent suicide. Results: The analysis identified significant correlations between unhealthy dietary patterns, hazardous drinking behavior, smoking, and a sleep duration of less than 5 h, all of which were associated with a heightened suicide risk among adolescents. Notably, underweight adolescents who had a sleep duration of less than 5 h demonstrated a markedly elevated risk of suicidal ideation (OR = 2.391, 95% CI [1.035-5.525]). Among overweight adolescents, frequent coffee consumption was significantly associated with both suicidal planning (OR = 1.850, 95% CI [1.133-3.020]) and suicide attempts (OR = 1.958, 95% CI [1.024-3.742]). Importantly, hazardous drinking behavior was strongly associated with suicide attempts (OR = 2.277, 95% CI [1.132-4.580]). Non-smoking behavior exhibited a significant relationship with a decreased likelihood of suicidal ideation (OR = 0.706, 95% CI [0.507-0.983]) and suicidal planning (OR = 0.528, 95% CI [0.299-0.930]). Furthermore, among obese adolescents, non-smoking behavior significantly decreased the risk of suicidal ideation compared to smoking (OR = 0.514, 95% CI [0.297-0.887]). Conclusions: The study revealed that the combined impact of unhealthy behaviors-smoking, eating an unhealthy breakfast, sleeping for less than 5 h, and hazardous drinking behavior-significantly affect suicide-related behaviors in adolescents. The interaction between BMI and lifestyle factors is a critical determinant of these behaviors. Specifically, sleep health exerts a substantial influence on suicide-related behaviors in underweight adolescents, while smoking strongly correlates with suicidal behaviors in overweight and obese adolescents. Targeted attention to the interplay of smoking, diet, sleep, and alcohol consumption with BMI is crucial for the early detection and prevention of adolescent suicide. | Wang, Haitao; Kim, Kyung-O | Kyungpook Natl Univ, Sociol Sports Act Aging Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea | Kim, Min Kyong/KJM-2767-2024 | 59759369800; 59966209800 | 2023034630@knu.ac.kr; kkim78@knu.ac.kr; | HEALTHCARE | HEALTHCARE-BASEL | 2227-9032 | 13 | 12 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2024 | 2.7 | 27.8 | 0 | 0 | health behaviors; lifestyle; adolescents; suicide; body mass index; cross-sectional study | PHYSICAL-ACTIVITY; HEALTH; CONSUMPTION; SMOKING | adolescents; body mass index; cross-sectional study; health behaviors; lifestyle; suicide | English | 2025 | 2025-06-18 | 10.3390/healthcare13121470 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Molecular insights into immune evasion in head and neck squamous cell carcinomas: Toward a promising treatment strategy | Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive and devastating disease arising primarily from the mucosal epithelium of the oral cavity, pharynx, and larynx. HNSCC ranks as the sixth most common cancer worldwide, carrying significant morbidity and mortality. HPV-positive HNSCC can be partially prevented with the FDA-approved HPV vaccine and generally exhibits a more favorable prognosis compared to HPVnegative cases. However, effective screening and treatment approaches remain elusive for HPV-negative HNSCC. While precancerous lesions may precede invasive cancer in certain situations, most patients present with advanced disease without prior indication of precancerous conditions. Despite robust immune cell infiltration in HNSCC tumors, the extent and composition of immune infiltration vary widely among patients, and these tumors often evade immune surveillance through diverse mechanisms. Given the heterogeneous nature of HNSCC influenced by anatomical location and etiological factors, precise identification of biomarkers and personalized treatment strategies are imperative. In this study, we aim to explore the possibility of establishing an effective treatment strategy to overcome obstacles to targeted treatment and enable long-term survival through detailed molecular characterization and immune profiling of HNSCC. | Kim, Hyeon Ji; Joo, Bo Kyung; Byun, Jin-Seok; Kim, Do-Yeon | Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41940, South Korea | 57216816929; 59337999900; 55430621800; 57203012542 | jsbyun@knu.ac.kr; dykim82@knu.ac.kr; | ONCOLOGY RESEARCH | ONCOL RES | 0965-0407 | 1555-3906 | 33 | 6 | SCIE | ONCOLOGY | 2024 | 4.1 | 27.8 | N/A | 0 | 0 | HNSCC; Human papillomavirus; Tumor microenvironment; Tumor-associated macrophage; Cancer-associated fi broblast | PROGNOSTIC BIOMARKER; OPEN-LABEL; CANCER; EXPRESSION; INFILTRATION; PATHWAY; ACTIVATION; TUMORS; PD-L1 | Cancer-associated fibroblast; HNSCC; Human papillomavirus; Tumor microenvironment; Tumor-associated macrophage | Biomarkers, Tumor; Head and Neck Neoplasms; Humans; Immune Evasion; Papillomavirus Infections; Squamous Cell Carcinoma of Head and Neck; Tumor Escape; Tumor Microenvironment; biological marker; Human papilloma virus vaccine; tumor marker; Alphapapillomavirus; anatomical location; cancer associated fibroblast; cell infiltration; controlled study; drug therapy; head and neck squamous cell carcinoma; human; human tissue; immune evasion; immunocompetent cell; immunological monitoring; immunosurveillance; long term survival; major clinical study; nonhuman; precancer; radiotherapy; review; tumor invasion; tumor microenvironment; tumor-associated macrophage; complication; head and neck tumor; immunology; papillomavirus infection; pathology; therapy; tumor escape; tumor microenvironment; virology | English | 2025 | 2025 | 10.32604/or.2025.062207 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development and Application of Lactobacillus plantarum PSCPL13 Probiotics in Olive Flounder (Paralichthys olivaceus) Farming | Aquaculture has grown significantly, contributing to global food security and sustainability; however, intensified fish farming has increased disease susceptibility and antibiotic resistance. This study assessed the probiotic potential of Lactobacillus plantarum PSCPL13 (hereafter, PSCPL13), isolated from the intestines of Japanese eels, for enhancing the health of olive flounder. After screening 16 Lactobacillus isolates, PSCPL13 was selected because of its potential broad-spectrum antibacterial activity against many pathogens, such as Vibrio and Edwardsiella. This strain exhibited high acid and bile salt tolerance, which is crucial for intestinal survival. Molecular characterisation confirmed PSCPL13 to be L. plantarum. It was resistant to all tested antibiotics and exhibited significant enzyme activity. In vivo assays in olive flounder revealed that the body weight and length of the fish were significantly higher, while the prevalence of pathogens was lower in their gut microbiota. Regarding haematological parameters, the treated groups exhibited lower eosinophil counts and higher IgM levels, suggesting enhancement of the immune system. These findings indicate that PSCPL13 is a potential probiotic that can be used in aquaculture for naturally improving fish health, growth and immunity, in addition to combating antibiotic resistance and reducing environmental impacts. These findings not only highlight the potential of PSCPL13 in sustainable aquaculture but also provide a foundation for the development of future probiotics. | Abbas, Muhammad Aleem; Kim, Hae-Jung; Lee, Ga-Yeong; Cho, Hae-Yeon; Sayem, Syed Al Jawad; Lee, Eon-Bee; Lee, Seung-Jin; Park, Seung-Chun | Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Aquat Life Med, Busan 48513, South Korea; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea; Kyungpook Natl Univ, Sch Med, Cardiovasc Res Inst, Daegu 41944, South Korea | Lee, Jinseok/ACF-1247-2022; Park, Seung-Chun/AAV-3388-2021; Abbas, Muhammad Aleem/GLT-8362-2022 | 57216531374; 57189901275; 58413330500; 59381256800; 57221340236; 57216526135; 58689440900; 7501832396 | syedaleemabbas77@gmail.com; seafog@hanmail.net; ga7464@naver.com; whgodus777@naver.com; aljawadsayem@gmail.com; eonbee@pknu.ac.kr; lee.seungjin@kitox.re.kr; parksch@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 13 | 1 | SCIE | MICROBIOLOGY | 2024 | 4.2 | 27.9 | 0 | 2025-05-07 | 0 | 1 | fish probiotic; aquaculture; fish gut microbiota; fish nutrition; aquatic microorganisms; Lactobacillus plantarum | ACID TOLERANCE; RAINBOW-TROUT; FISH; BACTERIA; ANTIBACTERIAL; PRODUCTS; INSIGHTS; BACILLUS; GROWTH; FEED | aquaculture; aquatic microorganisms; fish gut microbiota; fish nutrition; fish probiotic; Lactobacillus plantarum | English | 2025 | 2025-01 | 10.3390/microorganisms13010061 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Microbiota Analysis and Characterisation of the Novel Limosilactobacillus Strains Isolated from Dogs | Background/Objectives: The growing number of households with companion dogs raises concerns. Co-living environments between companion dogs and their owners are linked to a heightened risk of cross-infections from strains such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Salmonella, and faecal coliforms. Therefore, this study aims to propose measures for healthy cohabitation by analysing the faecal microbiota of puppies and adult dogs. Methods: We isolated lactic acid bacteria (LAB) from their faeces and assessed their potential to inhibit E. coli, S. aureus, and Salmonella spp. Faecal samples from puppies (12 months old) were analysed and compared. Results: The analysis revealed that Lactobacillus dominated puppy faeces, while Bacteroidetes were more abundant in adult dogs. In total, 109 primary LAB candidates were isolated from faecal samples. These isolates underwent secondary screening for acid tolerance, bile salt resistance, acid production, heat resistance, protease activity, and antimicrobial activity against E. coli, S. aureus, and Salmonella spp. Five secondary LAB candidates with probiotic potential were further characterised via morphological and genetic analysis. All five strains were Lactobacillus reuteri, with L. reuteri JJ37, JJ68, JJ69, JJ71, and JJ77 emerging as the final probiotic candidates. Conclusions: They promote healthier cohabitation between dogs and their owners. | Lee, Ga-Yeong; Jo, Hae-Yeon; Abbas, Muhammad Aleem; Gui, Ling; Ali, Md Sekendar; Kim, Seung-Jun; Park, Seung-Chun | Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Vet Obstet, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41566, South Korea | Abbas, Muhammad Aleem/GLT-8362-2022 | 58413330500; 59919866700; 57216531374; 59919682700; 57219661221; 59920233900; 59260415700 | yeong1129@knu.ac.kr; whgodus@knu.ac.kr; syedaleemabbas77@gmail.com; guiling@knu.ac.kr; alipharm2000@gmail.com; kjoon00@knu.ac.kr; parksch@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 13 | 5 | SCIE | MICROBIOLOGY | 2024 | 4.2 | 27.9 | 0 | 2025-06-11 | 0 | 0 | dogs; lactic acid bacteria; microbiota; probiotic | LACTIC-ACID BACTERIA; LACTOBACILLUS-ACIDOPHILUS; FOODBORNE PATHOGENS | dogs; lactic acid bacteria; microbiota; probiotic | English | 2025 | 2025-05-01 | 10.3390/microorganisms13051059 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | New Insights into the Synergistic Interaction Between Pseudomonas qingdaonensis NZ 1 and Silicon to Mitigate Drought Stress in Rice | The current study assessed the synergistic effects of PGPR and Si in alleviating drought stress in rice. Bacteria were isolated from Phragmites australis inhabiting an urban riverbank. Among the isolated strains, Pseudomonas qingdaonensis NZ 1 showed promising results under in vitro drought stress induced by PEG-6000 (-0.28 MPa). To further investigate the synergistic effect of Pseudomonas qingdaonensis NZ 1 and silicon, a plant growth experiment was conducted comprising the control (dH2O) and plants treated with NZ 1, Si (1 mM), and NZ 1+Si under normal and drought stress conditions. The results revealed that NZ 1+Si-treated plants showed improved plant growth parameters, chlorophyll contents, relative water contents, antioxidant potential, and nutrient uptake under normal and drought conditions. Moreover, endogenous abscisic acid and jasmonic acid levels were substantially reduced, while the salicylic acid level was increased in NZ 1+Si-treated plants. Moreover, the relative expression of the ABA metabolic genes OsNCED3 and OsCYP707A6 and transcription factors OsbZIP23 and OsDREB1B were significantly altered. Furthermore, the leaf Si, calcium, potassium, and phosphorus contents were increased in NZ 1+Si-treated drought-stressed plants, along with the upregulation of OsLSi1. The combined application of NZ 1 and Si offers a sustainable agricultural strategy to effectively mitigate the detrimental effects of drought. | Zainurin, Nazree; Imran, Muhammad; Shaffique, Shifa; Khan, Muhammad Aaqil; Kang, Sang-Mo; Injamum-UL-Hoque, Md.; Das, Ashim Kumar; Yun, Byung-Wook; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Natl Inst Agr Sci Rural Dev Adm, Biosafety Div, Jeonju 54874, South Korea; Qurtuba Univ, Dept Chem & Life Sci, Peshawar 25000, Pakistan | shaffique, shifa/KUC-7102-2024; Khan, Muhammad/ABB-9797-2021; Injamum-Ul-Hoque/ADJ-9141-2022; Das, Ashim Kumar/ABB-6751-2020; Kang, Sang-Mo/MBG-7823-2025 | 58777436700; 58282433800; 57203898867; 57188585606; 56189696900; 58663974700; 57211473983; 8245123600; 16425830900 | nazreezainurin@hotmail.com; shifa.2021@knu.ac.kr; ijlee@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 13 | 5 | SCIE | MICROBIOLOGY | 2024 | 4.2 | 27.9 | 0 | 2025-06-11 | 0 | 0 | PGPR; plant-microbe interaction; reactive oxygen species; phytohormones; silicon; synergism; drought stress | SPHINGOMONAS SP LK11; PLANT-GROWTH; PHOSPHATE SOLUBILIZATION; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; JASMONIC ACID; TOLERANCE; ABA; RHIZOSPHERE; L. | drought stress; PGPR; phytohormones; plant–microbe interaction; reactive oxygen species; silicon; synergism | English | 2025 | 2025-04-30 | 10.3390/microorganisms13051046 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Preliminary Insights into the Gut Microbiota of Captive Tigers in Republic of Korea: Influence of Geographic and Individual Variation | The gut microbiome plays a crucial role in the health and physiology of tigers (Panthera tigris), influencing digestion, immune function, and overall well-being. While numerous studies have characterized the gut microbiota of domestic carnivores and some wild felids, comparative analyses across different tiger subspecies under varying environmental contexts remain limited. In this exploratory study, we investigated the gut microbiome diversity and composition of 15 captive tigers, including both Siberian (P. tigris altaica) and Bengal (P. tigris tigris) subspecies, housed in two different regions in Korea. Using 16S rRNA gene sequencing of fecal samples, we analyzed microbial diversity across multiple taxonomic levels. Preliminary analyses revealed significant differences in microbial composition between geographic locations, whereas sex-based differences appeared minimal. Alpha and beta diversity metrics demonstrated substantial inter-individual variability, likely influenced by regional and environmental factors. Given the small sample size and the confounding between subspecies and housing location, the findings should be regarded as preliminary and not generalized beyond this specific cohort. Nevertheless, these insights highlight the potential utility of gut microbiome profiling for health monitoring and management in captive-tiger populations. Future research incorporating larger, more diverse cohorts will be essential to validate these trends and clarify the roles of diet, health status, and enrichment in shaping the gut microbiota. | Kim, Beoul; Lee, Saebom; Lee, You-Jeong; Kang, Yong-Myung; Rhee, Man Hee; Kwak, Dongmi; Yeo, Yong-Gu; Kang, Ju Won; Kim, Taehwan; Seo, Min-Goo | Kyungpook Natl Univ, Coll Vet Med, 80 Daehak ro, Daegu 41566, South Korea; Korean Tiger Coservat Ctr, Baekdudaegan Natl Arboretum, 1501 Chunyang ro, Bonghwa 36209, South Korea; Seoul Zoo, Conservat & Hlth Ctr, 102 Daegongwongwangjang ro, Gwacheon si 13829, South Korea; Uchi Pk Zoo, Vet Med Team, 677 Uchi ro, Gwangju 61028, South Korea | Seo, Min-Goo/NQF-4335-2025; Rhee, Man/O-5705-2016 | 59343608800; 58785224700; 59343760600; 59702372200; 59914898600; 7007148758; 35277545300; 59964036800; 57202984578; 58950739700 | kbjjhnm@naver.com; gltp43@koagi.or.kr; wowgirlsgood@naver.com; kamaboy88@knu.ac.kr; rheemh@knu.ac.kr; dmkwak@knu.ac.kr; withyonggu@seoul.go.kr; gjw0210@korea.kr; thkim56@naver.com; koreasmg@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 13 | 6 | SCIE | MICROBIOLOGY | 2024 | 4.2 | 27.9 | 0 | 0 | tiger gut microbiome; microbial diversity; 16S rRNA gene sequencing; Siberian tiger; Bengal tiger; captivity; conservation | CHAIN FATTY-ACIDS; BACTERIAL; HUMANS; DOGS | 16S rRNA gene sequencing; Bengal tiger; captivity; conservation; microbial diversity; Siberian tiger; tiger gut microbiome | English | 2025 | 2025-06-19 | 10.3390/microorganisms13061427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Application of Real-World Evidence to Support FDA Regulatory Decision Making | Real-world data (RWD) and real-world evidence (RWE) are valuable resources for drug development strategies. Historically, it has been used for safety evaluation during post-marketing surveillance. RWD and RWE have been utilized in the regulatory decision-making process for drug effectiveness, especially for rare diseases and cancers, where conducting randomized controlled trials is challenging. The Food and Drug Administration (FDA) is actively working on providing trustworthy information derived from RWD and RWE to supplement the data from clinical trials. This review discusses the potential use of RWE to make regulatory decisions on drug effectiveness for certain therapeutic areas as well as the challenges in drawing inferences on drug effectiveness from RWE. A review of FDA-approved new drug applications and biologics license applications suggests that several methodological considerations should be deliberated when designing a study using RWE to demonstrate product effectiveness. The acceptance of RWE, while promising, is dependent on the relevance and reliability of the data. The insight and engagement of all stakeholders contribute to the successful use of RWE for clinical evaluations. | Khaowroongrueng, Vipada; Kim, Tae-Eun; Park, Sang-In; Shin, Kwang-Hee | Govt Pharmaceut Org, Res Dev & Innovat Dept, Bangkok, Thailand; Konkuk Univ, Dept Clin Pharmacol, Med Ctr, Seoul, South Korea; Kangwon Natl Univ, Coll Med, Dept Pharmacol, Chunchon, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Infect Dis Healthcare, Daegu 41566, South Korea | 57191581545; 59917334200; 59917575400; 35216279300 | kshin@knu.ac.kr; | AAPS JOURNAL | AAPS J | 1550-7416 | 27 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.7 | 28.0 | 0 | 2025-06-11 | 0 | 0 | FDA; real-world evidence; regulatory decision making | NATURAL-HISTORY; GUIDELINES; DISEASES | FDA; real-world evidence; regulatory decision making | Biological Products; Decision Making; Drug Approval; Drug Development; Humans; United States; United States Food and Drug Administration; biological product; adverse drug reaction; biologic license application; clinical evaluation; decision making; drug development; drug efficacy; Food and Drug Administration; human; malignant neoplasm; new drug application; postmarketing surveillance; randomized controlled trial; reliability; review; trustworthiness; drug approval; drug development; procedures; United States | English | 2025 | 2025-05-28 | 10.1208/s12248-025-01082-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sinapic Acid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents That Target Transforming Growth Factor β-Activated Kinase 1 (TAK1) | Recent in vitro studies have reported that sinapic acid (SPA) binds to transforming growth factor-beta-activated kinase 1 (TAK1), a key regulator of inflammatory pathways. However, the hydrophobic nature of SPA limits its solubility in aqueous environments, posing challenges for in vivo biomedical applications. Thus, we synthesized Gd-DO3A-SPA by conjugating SPA with a gadolinium-based magnetic resonance imaging (MRI) contrast agent to improve its solubility. Gd-DO3A-SPA was then evaluated as a theranostic agent capable of both diagnosing inflammatory lesions via MRI and modulating inflammation by directly targeting TAK1. The physicochemical properties of the synthesized Gd-DO3A-SPA were analyzed by using MRI. The diagnostic and therapeutic effects of Gd-DO3A-SPA on inflammation were evaluated in a mouse inflammation model. TAK1 binding was investigated using cellular thermal shift assay, drug affinity responsive target stability, and in silico studies. The conjugated Gd-DO3A-SPA showed superior signal enhancement in inflamed tissue compared with the extracellular MR agent, Gadobutrol. Additionally, it was found to inhibit inflammatory cytokines, such as inducible nitric oxide synthase, cyclooxygenase 2, interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha, as well as the NLRP3 inflammasome, through the nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways. Furthermore, this study demonstrated that Gd-DO3A-SPA was internalized into cells via endocytosis and directly bound to the TAK1 protein. In conclusion, Gd-DO3A-SPA demonstrated its potential as a theranostic agent that targets TAK1 at the site of inflammation and inhibits inflammatory factors; meanwhile, inflammation can be diagnosed by using MRI. | Lee, Sangyun; Ahn, Dabin; Baek, Ahrum; Sung, Bokyung; Yang, Byeongwoo; Kim, Minsup; Park, Ji-Ae; Lee, Gang Ho; Lee, Eunshil; Chang, Yongmin | Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41566, South Korea; Theranocure Co Ltd, Daegu 41405, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41944, South Korea; Kyungpook Natl Univ, ICT Convergence Res Ctr, Daegu 41566, South Korea; TARS Sci, Seoul 01662, South Korea; Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 139706, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea | 58034650700; 58679951200; 57194601711; 58929528400; 57195807615; 56122945800; 59760966200; 7404851841; 25925922900; 7501840633 | leees82@naver.com; ychang@knu.ac.kr; | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | ACS PHARMACOL TRANSL | 2575-9108 | 8 | 6 | ESCI | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2024 | 3.7 | 28.0 | 0 | 2025-06-11 | 0 | 0 | sinapic acid; anti-inflammation; MRI contrastagent; theranostic agent; TAK1 | CONTRAST AGENTS; TRANSMETALATION; DEGRADATION; DERIVATIVES; STABILITY; PATHWAY | anti-inflammation; MRI contrast agent; sinapic acid; TAK1; theranostic agent | cyclooxygenase 2; gadobutrol; gadolinium; inducible nitric oxide synthase; inflammasome; interleukin 1beta; interleukin 6; mitogen activated protein kinase; sinapic acid; transforming growth factor beta activated kinase 1; tumor necrosis factor; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; B lymphocyte; complex formation; controlled study; drug conjugation; drug solubility; drug synthesis; endocytosis; human; human cell; in vitro study; lipophilicity; mouse; myositis; nonhuman; nuclear magnetic resonance imaging; physical chemistry; protein binding; protein phosphorylation; protein targeting; theranostic nanomedicine | English | 2025 | 2025-06-02 | 10.1021/acsptsci.5c00220 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Addressing data scarcity in speech emotion recognition: A comprehensive review | Speech emotion recognition (SER) is a critical field within affective computing, aiming to detect and classify emotional states from speech signals, which vary dynamically over time. These signals encode complex relationships between features at multiple time scales, effectively reflecting a speaker's emotional state. Despite significant progress, SER faces the persistent challenge of labeled data scarcity, a major obstacle given the data-intensive requirements of deep learning models. This scarcity often results in small, imbalanced datasets that hinder model generalization. Various strategies, including feature selection, data augmentation, domain adaptation, and fusion techniques, have been employed to mitigate these issues. However, comprehensive reviews that critically analyze these methods remain limited. In this paper, we provide an extensive review of these data scarcity strategies in SER, assessing their merits and limitations in terms of efficiency and robustness. Special attention is given to how these strategies enhance the performance of both acoustic and multimodal SER systems when operating on limited datasets. Additionally, we highlight the potential of fusion strategies combined with attention mechanisms as promising solutions to improve convergence and reduce model complexity. | Kakuba, Samuel; Han, Dong Seog | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kabale Univ, Fac Engn Technol Appl Design & Fine Art, Kabale 317, Uganda | Han, Dong Seog/N-8949-2018; Kakuba, Samuel/HLX-4856-2023 | 57988218000; 7403219442 | 2021327392@knu.ac.kr; dshan@knu.ac.kr; | ICT EXPRESS | ICT EXPRESS | 2405-9595 | 11 | 1 | SCIE | TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.2 | 28.1 | 2.35 | 2025-05-07 | 1 | 1 | Emotion recognition; Data scarcity; Limited datasets; Attention mechanisms | SENTIMENT ANALYSIS; FUSION; TEXT | Attention mechanisms; Data scarcity; Emotion recognition; Limited datasets | English | 2025 | 2025-02 | 10.1016/j.icte.2024.11.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Artificial intelligence based prediction of refractive index profile of graded refractive index optical fiber | This research presents a deep neural network (DNN) approach for predicting the refractive index profile in graded-index multimode fibers (GRIN MMFs). The model was trained using simulated data and achieved an average loss less than 1% across both selected (or structured) and random test sets. This artificial intelligence-driven approach has potential applications in custom fiber design, nonlinear optics, and rapid fiber performance characterization. Future developments may include the use of real-world data and the extension of the model to predict refractive index profiles, further enhancing its versatility. © 2025 | Lee, Seung-Yeol; Kim, Hyuntai | School of Electronic and Electrical Engineering, College of IT Engineering, Kyungpook National University, Daegu, 41566, South Korea; Electrical and Electronic Convergence Department, Hongik University, Sejong, 30016, South Korea | 55881869300; 57218447829 | hyuntai@hongik.ac.kr; | ICT Express | ICT EXPRESS | 2405-9595 | 2405-9595 | SCIE | TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.2 | 28.1 | 0 | 2025-06-11 | 0 | Artificial intelligence; Graded index optical fiber; Refractive index profile | English | Article in press | 2025 | 10.1016/j.icte.2025.05.011 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Design of a gate-all-around arch-shaped tunnel-field-effect-transistor-based capacitorless DRAM | In this study, we designed and analyzed a single-transistor dynamic random-access memory (1 T-DRAM) based on an arch-shaped gate-all-around tunnel field-effect transistor (GAA ARCH-TFET), featuring an Si/SiGe heterostructure, for high-density memory applications. Unlike conventional 1 T-DRAM, which relies on the electric-field-driven movement of charge carriers through a channel for the read operation, the GAA ARCH-TFET 1 T-DRAM utilizes band-to-band tunneling. The GAA structure improves scalability, making it suitable for high-density memory applications. This capacitorless GAA ARCH-TFET 1 T-DRAM cell demonstrates both superior performance and low energy consumption. The arch-shaped design expands the tunneling area, while the Si/SiGe heterostructure forms a quantum well that further enhances memory performance. The effects of key parameters, including source height, channel height, and germanium composition, on device behavior are examined. Simulation results reveal that the GAA ARCH-TFET 1 T-DRAM achieves a high current ratio of read "1" to read "0" (10(8)) and a retention time exceeding 1 s at 358 K. These characteristics suggest that the proposed device holds potential as a DRAM replacement in various applications. | Bae, Seung Ji; Lee, Sang Ho; Park, Jin; Kim, Min Seok; Hong, Jeong Woo; Koh, Won Suk; Yun, Gang San; Jang, Jaewon; Bae, Jin-Hyuk; Kang, In Man | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Lee, Sang Ho/MCX-8396-2025 | 58485369600; 57416738400; 57376422900; 59073001500; 58485369700; 59508365800; 59507956800; 57194107504; 35326180700; 7203062678 | imkang@ee.knu.ac.kr; | DISCOVER NANO | DISCOV NANO | 2731-9229 | 20 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2024 | 4.5 | 28.1 | 0 | 2025-05-07 | 0 | 0 | Band-to-band; Tunneling; Capacitorless dynamic random-access memory; Gate-all-around; Heterostructure; SiGe; Tunnel field-effect transistor | RANDOM-ACCESS MEMORY; RETENTION TIME; 1T DRAM; OPTIMIZATION; 1T-DRAM; FET | Band-to-band; Capacitorless dynamic random-access memory; Gate-all-around; Heterostructure; SiGe; Tunnel field-effect transistor; Tunneling | Capacitor bank; Dynamic random access storage; Ferroelectric RAM; Gallium arsenide; Gates (transistor); Germanium compounds; Heterojunctions; Integrated circuit design; Junction gate field effect transistors; Silicon wafers; Static random access storage; Structural dynamics; Surface discharges; Tunnel field effect transistors; Band-to-band; Capacitor-less; Capacitorless dynamic random access memory; Field-effect transistor; Gate-all-around; High density memory; Memory applications; Si/SiGe heterostructures; Single transistors; Tunneling; Semiconductor quantum wells | English | 2025 | 2025-04-02 | 10.1186/s11671-025-04233-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DMAE-HU: A novel deep multitasking autoencoder for hybrid hyperspectral unmixing in remote sensing | Hyperspectral unmixing (HU) is crucial for extracting material information from hyperspectral images (HSI) obtained through remote sensing. Although linear unmixing methods are widely used due to their simplicity, they only address linear mixing effects. Nonlinear mixing models, while more complex, often focus solely on the nonlinear aspects affecting individual pixels. However, in practice, light reflected from materials within a pixel experiences linear and nonlinear interactions, necessitating a hybrid mixing model (HMM) that leverages spatial and spectral information. This work proposes a novel deep learning-based autoencoder (AE) with dual-stream decoders to enhance spectral unmixing. Our approach employs multitask learning (MTL) to process spatial and spectral information concurrently. Specifically, one decoder stream performs linear unmixing from HSI patches, while the other stream utilizes fully connected layers to capture and model the nonlinear interactions within the data. By integrating linear and nonlinear information, our method improves the accuracy of unmixing the mixed spectrum. We validate the effectiveness of our architecture on three real-world HSI datasets and compare its performance against various baseline methods. Experimental results consistently demonstrate that our approach outperforms existing methods, as evidenced by superior spectral angle distance (SAD) and mean squared error (MSE) metrics. | Aala, Suresh; Pavuluri, Prudhvi Krishna; Deshpande, Anuj; Sikhakolli, Sravan Kumar; Elumalai, Karthikeyan; Chinnadurai, Sunil; Panchakarla, Eswar; Sarker, Md. Abdul Latif; Han, Dong Seog | SRM Univ AP, Sch Engn & Sci, Dept Elect & Commun Engn, Amaravati 522502, Andhra Pradesh, India; SRM Univ AP, Sch Engn & Sci, Dept Comp Sci & Engn, Amaravati 522502, Andhra Pradesh, India; Kyungpook Natl Univ, Ctr ICT & Automot Convergence, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Han, Dong Seog/N-8949-2018; Chiinnadurai, Sunil/IUM-1982-2023; Aala, Suresh/JLL-3242-2023; Deshpande, Anuj/AAZ-4050-2021 | 57539297000; 59486107500; 57192917442; 59426166900; 57265798900; 57485185900; 59486107400; 42262729500; 7403219442 | suresh_aala@srmap.edu.in; prudhvikrishna_pavuluri@srmap.edu.in; deshpande.a@srmap.edu.in; sravankumar_sikhakoli@srmap.edu.in; karthikeyan.e@srmap.edu.in; sunil.c@srmap.edu.in; eswar_panchakarla@srmap.edu.in; latifsarker@knu.ac.kr; dshan@knu.ac.kr; | ICT EXPRESS | ICT EXPRESS | 2405-9595 | 11 | 2 | SCIE | TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.2 | 28.1 | 0 | 2025-05-07 | 0 | 0 | Hyperspectral imaging; Hybrid mixing model; Spectral-spatial unmixing; Non-linearity; Multitasking | SEGMENTATION | Hybrid mixing model; Hyperspectral imaging; Multitasking; Non-linearity; Spectral-spatial unmixing | English | 2025 | 2025-04 | 10.1016/j.icte.2025.01.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fabrication of SiO2/graphite composites with enhanced performance in supercapacitor electrodes | We present an efficient approach for synthesizing thin graphite-coated SiO2 composites (TGCSCs) for supercapacitor applications, by encapsulating SiO2 particles within multilayered graphene using thermal chemical vapor deposition. The TGCSC maintains the original morphology of the SiO2 particles, with the graphite layer exhibiting an interlayer distance of similar to 0.34 nm. Surface analysis revealed the formation of Si-C and SiO-C bonds, which enhanced the conductivity and overall performance; in addition, acid treatment improved the electrode wettability by increasing the content of -OH groups, contributing to significant enhancement of the electrochemical performance. In a three-electrode system, the TGCSC electrode retained 99% of its initial capacitance after 5000 cycles in 1M H2SO4. These findings highlight the potential of SiO2/graphite composites as high-performance supercapacitor materials employing cost-effective and widely available resources. (c) 2025 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution-Non Commercial 4.0International (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).https://doi.org/10.1063/5.0256466 | Jung, Jinjoo; Kim, Chang-Duk; Oh, Jihun; Pae, Hanung; Kang, Kyeong Tae; Kang, Seung Beom; Jo, Younjung | Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, KNU G LAMP Project Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Carbon Ind Promot Agcy, Res & Dev Ctr, Jeonju Si 54853, Jeollabuk Do, South Korea | Oh, Jihun/B-7085-2013 | 55750032400; 57200982445; 59679608100; 59679174900; 59815482000; 58032913000; 13502586500 | sbkang@kcarbon.or.kr; jophy@knu.ac.kr; | APL MATERIALS | APL MATER | 2166-532X | 13 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2024 | 4.5 | 28.1 | 0 | 2025-05-07 | 0 | 0 | ELECTROCHEMICAL PROPERTIES; MICRO-SUPERCAPACITORS; SURFACE OXIDATION; POROUS SILICON; GRAPHENE; NANOPARTICLES; STORAGE; OXIDE | Carbon carbon composites; Chemical vapor deposition; Composite coatings; Germanium compounds; Silicon compounds; Silicon oxides; Graphite composites; Graphite layers; Graphite-coated; Interlayer distance; Multi-layered graphene; Performance; SiO 2; Supercapacitor application; Supercapacitor electrodes; Thermal chemical vapor deposition; Graphite electrodes | English | 2025 | 2025-03-01 | 10.1063/5.0256466 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Review | Multiple object detection and tracking in autonomous vehicles: A survey on enhanced affinity computation and its multimodal applications | Three-dimensional (3D) object tracking is crucial in computer vision applications, particularly in autonomous driving, robotics, and surveillance. Despite advancements, effectively utilizing multimodal data to improve multi-object detection and tracking (MODT) remains challenging. This study introduces ACMODT, an affinity computation-based multi-object detection and tracking framework that integrates camera (2D) and LiDAR (3D) data for enhanced MODT performance in autonomous driving. This approach leverages EPNet as a backbone, utilizing 2D–3D feature fusion for accurate proposal generation. A deep neural network (DNN) extracts robust appearance and geometric features, while an improved affinity computation module combines Refined Boost Correlation Features (RBCF) and 3D-Extended Geometric IoU (3D-XGIoU) for precise object association. Motion prediction is refined using a Kalman filter (KF), and Gaussian Mixture Model (GMM)-based data association ensures consistent tracking. Experiments on the KITTI car tracking benchmark for quantitative analysis and the RADIATE dataset for visualization demonstrate that our method achieves superior tracking accuracy and precision compared to state-of-the-art multi-object tracking (MOT) approaches, proving its effectiveness for real-time object tracking. © 2025 The Authors | Altaf, Muhammad Adeel; Kim, Min Young | School of Electronic and Electrical Engineering, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu, 41566, South Korea; School of Electronic and Electrical Engineering, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu, 41566, South Korea, Research Center for Neurosurgical Robotic System, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu, 41566, South Korea, KNU-LG Electronics Convergence Research Center, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu, 41566, South Korea | 57609122300; 56739349100 | minykim@knu.ac.kr; | ICT Express | ICT EXPRESS | 2405-9595 | 2405-9595 | SCIE | TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.2 | 28.1 | 0 | Affinity computation; Autonomous driving; Deep neural network; Gaussian mixture model-based data association; Multi-object tracking | English | Article in press | 2025 | 10.1016/j.icte.2025.06.005 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | ○ | Article | Novel three-dimensional stacked capacitorless DRAM architecture using partially etched nanosheets for high-density memory applications | This study presents a novel three-dimensional stacked capacitorless dynamic random access memory (1T-DRAM) architecture, designed using a partially etched nanosheet (PE NS) to overcome the scaling limitations of traditional DRAM designs. By leveraging the floating body effect, this architecture eliminates the need for capacitors, thereby improving integration density and memory performance. Through Sentaurus technology computer-aided design simulations, we compare the PE NS 1T-DRAM device with a conventional NS 1T-DRAM device to evaluate its effectiveness. The results reveal superior retention time (RT) and sensing margin (SM) performance of the proposed PE NS 1T-DRAM device, surpassing the memory criteria outlined by the International Roadmap for Devices and Systems, which requires an RT exceeding 64 ms at 358 K. This enhanced performance of the proposed device is attributed to its extension region, which functions as a potential well for efficient hole storage, as well as the suppression of Shockley-Read-Hall recombination. The PE NS 1T-DRAM device also demonstrates robustness to disturbances, maintaining over 89% of its SM and RT under diverse conditions. This superiority is again attributed to its extension region, which minimizes the effects of current flow and electrostatic potential rise. These results highlight the potential of the PE NS 1T-DRAM design for future high-density memory applications. | Kim, Min Seok; Lee, Sang Ho; Park, Jin; Bae, Seung Ji; Hong, Jeong Woo; Koh, Won Suk; Yun, Gang San; Jang, Jaewon; Bae, Jin-Hyuk; Kang, In Man | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Lee, Sang Ho/MCX-8396-2025 | 59073001500; 57416738400; 57376422900; 58485369600; 58485369700; 59508365800; 59507956800; 57194107504; 35326180700; 7203062678 | imkang@ee.knu.ac.kr; | DISCOVER NANO | DISCOV NANO | 2731-9229 | 20 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2024 | 4.5 | 28.1 | 0 | 2025-05-07 | 0 | 0 | Three-dimensional; Capacitorless dynamic random access memory (1T-DRAM); Nanosheet; Floating body effect; Disturbance | RANDOM-ACCESS MEMORY; 1T DRAM; GATE; PERFORMANCE; CHALLENGES; 1T-DRAM; FUTURE | Capacitorless dynamic random access memory (1T-DRAM); Disturbance; Floating body effect; Nanosheet; Three-dimensional | Capacitor bank; Capacitor storage; Computer aided logic design; Dynamic random access storage; Hall effect devices; Integrated circuit design; Memory architecture; Static random access storage; Structural analysis; System-on-chip; Three dimensional integrated circuits; Capacitorless dynamic random access memory; Capacitorless dynamic random access memory (1t-DRAM); Disturbance; DRAM design; DRAM devices; Floating body effect; High density memory; Memory applications; Retention time; Sensing margin; Nanosheets | English | 2025 | 2025-02-10 | 10.1186/s11671-025-04201-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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