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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Source distribution, ecological risks, and controlling factors of heavy metals in river sediments: Receptor model-based study in a transboundary river basin | In the context of transboundary rivers, which constitute intricate fluvial ecosystems, the persistent threat of heavy metals (HMs) contamination poses significant risks to ecosystem health. In this study, ecotoxicological hazards, governing factors, and the distribution of nine HMs (uranium (U), lead (Pb), cadmium (Cd), nickel (Ni), chromium (Cr), manganese (Mn), iron (Fe), zinc (Zn), and copper (Cu)), as well as sediment characteristics (sand, silt, clay, organic matter, and pH) are assessed within the sediment. The current investigation encompasses the analysis of twenty-seven sediment samples, utilizing inductively coupled plasma mass spectrometry, in the transboundary river basin of Bangladesh, specifically the Teesta River. Notably, the findings underscore the predominance of Cd as a contaminant, responsible for 51.85%, 81.84%, and 100% of the geo-accumulation index, contamination factor, and enrichment factor, respectively. The Teesta River emerges as moderately to highly polluted, with cumulative probabilities of 7.4%, 85.2%, and 7.4% denoting "medium", "high", and "priority" pollution levels, respectively. Regions in the upstream and downstream middle sections of the study area exhibit relatively higher pollution levels, particularly in proximity to Kaunia Upazila in the Rangpur district. Ecologically, the potential risk index indicates a low likelihood of ecological impacts at 77.8%, alongside a moderate risk observation of 22.2%. The current results attribute the distribution of these HMs to the pH and organic matter content within the sediment, serving as pivotal factors. To unravel the origins of the HMs, the positive matrix factorization (PMF) model successfully identifies four contributing factors, primarily from geogenic sources. Validation of the PMF model through Spearmen correlation and principal component analysis (PCA) reveals a consistent pattern, affirming its efficacy in this analysis. Within the region, HM sources are identified as originating from anthropogenic activities such as irrigation, industrial discharges, and domestic effluent, in addition to substantial inputs from geogenic sources. Recognizing the transboundary nature of metal pollution, the current study underscores the imperative for continuous and vigilant monitoring, coupled with the implementation of robust management practices. The interplay of both anthropogenic and geogenic factors necessitates a comprehensive approach to effectively and sustainably combat HM contamination. (c) 2024 International Research and Training Centre on Erosion and Sedimentation. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY- NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Islam, Abu Reza Md Towfiqul; Rabbi, Abu Hena Md Fazla; Anik, Amit Hasan; Khan, Rahat; Al Masud, Md Abdullah; Nedjoud, Grara; Idris, Abubakr M.; Rahman, Md Naimur; Senapathi, Venkatramanan | Begum Rokeya Univ, Dept Disaster Management, Rangpur 5400, Bangladesh; Daffodil Int Univ, Dept Dev Studies, Dhaka 1216, Bangladesh; Bangladesh Univ Profess BUP, Dept Environm Sci, Mirpur-12, Dhaka 1216, Bangladesh; Bangladesh Atom Energy Commiss BAEC, Inst Nucl Sci & Technol, Dhaka 1349, Bangladesh; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Univ 8 May 1945 Guelma, Fac Nat & Life Sci Earth & Universe, Dept Biol, POB 401, Guelma 24000, Algeria; King Khalid Univ, Coll Sci, Dept Chem, Abha 62529, Saudi Arabia; King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, Abha 62529, Saudi Arabia; Hong Kong Baptist Univ, Dept Geog, Kowloon, Hong Kong, Peoples R China; Natl Coll Autonomous, PG & Res Dept Biotechnol, Tiruchirappalli 620001, Tamil Nadu, India | Rahman, Md Naimur/GQO-9250-2022; Masud, Md Abdullah Al/JEF-1055-2023; Islam, Abu/AAN-8105-2020; Towfiqul Islam, Abu Reza Md./N-4022-2014; Idris, Abubakr/JWO-9124-2024; Anik, Amit/KFQ-7955-2024; Venkatramanan, Dr Senapathi/K-8125-2013; Senapathi, Venkatramanan/K-8125-2013 | 57218543677; 59389607000; 57405675800; 56501271600; 57542255300; 55155620000; 57893996600; 57221260769; 35147076400 | towfiq_dm@brur.ac.bd; | INTERNATIONAL JOURNAL OF SEDIMENT RESEARCH | INT J SEDIMENT RES | 1001-6279 | 2589-7284 | 40 | 1 | SCIE | ENVIRONMENTAL SCIENCES;WATER RESOURCES | 2024 | 3.7 | 25.6 | 23.36 | 2025-05-07 | 5 | 7 | Teesta river; Bangladesh; Probable sources; Geo-environmental indices; Pollution level | SOURCE APPORTIONMENT; TRACE-ELEMENTS; SURFACE SEDIMENTS; BOTTOM SEDIMENTS; TOXIC METALS; URBAN RIVER; ROAD DUST; WATER; CONTAMINATION; POLLUTION | Bangladesh; Geo-environmental indices; Pollution level; Probable sources; Teesta river | Bangladesh; Teesta River; cadmium; fluvial deposit; heavy metal; human activity; management practice; organic matter; pollutant source; risk assessment; sediment pollution; transboundary pollution | English | 2025 | 2025-02 | 10.1016/j.ijsrc.2024.10.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Entwined Liberations: North Korean Democratic Women's Union and Third World Internationalism, 1945–1949 | This research focuses on how the North Korean Democratic Women's Union (NKDWU), the umbrella women's organisation in North Korea formed soon after Korea's liberation from Japanese colonial rule in 1945, forged international leftist women's solidarity during the North Korean state's liminal, revolutionary period (1945–1949). The NKDWU articulated that the North Korean women's model of entwined liberations between the revolutionary state and women, as well as among international women's groups, could guide Third World women toward their own postcolonial liberations. This early international solidarity had reciprocal impact: the concept of NKDWU's entwined liberations evolved into a cosmopolitan vision as their interactions increased with international women's organisations, while the agendas of anti-imperialism and aspirations of decolonisation initiated by Asian women that culminated at the 1949 Asian Women's Conference shifted the core tenets of transnational feminism. © 2025 John Wiley & Sons Ltd. | Hwang, Taejin | Department of History, Kyungpook National University, Daegu, South Korea | 57203010719 | hwangtj@knu.ac.kr; | Gender and History | GEND HIST | 0953-5233 | 1468-0424 | AHCI;SSCI | HISTORY;WOMENS STUDIES | 2024 | 0.4 | 25.7 | 0 | 2025-05-07 | 0 | English | Article in press | 2025 | 10.1111/1468-0424.12840 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Enhanced SnO2 FETs via selective area fluorine doping | In this study, a selective fluorine (F) doping process was developed to enhance the performance of field-effect transistors (FETs) with SnO2 channels deposited by thermal atomic layer deposition. The fluorination process was applied selectively to the source (S) and drain (D) regions of the SnO2 FETs. Fluorination of the S/D regions before the annealing step of the SnO2 channel resulted in a significant improvement in specific contact resistivity (rho(c)), reducing it from 1.1 x 10(-2) to 3.1 x 10(-3) Omega cm(2) - more than a threefold enhancement compared to SnO2 FETs without S/D fluorination. However, in this case, the SnO2 channel could not be modulated, likely due to the diffusion of F ions into the channel during the annealing process. When fluorination was applied to the annealed SnO2 channel, an on/off ratio of 2.4 x 10(8) was achieved. However, rho(c) was 9.1 x 10(-3) Omega cm(2), showing only a 15 % improvement compared to untreated SnO2 FETs. To address this limitation, a two-step approach was developed for SnO2 FETs, in which F-doped S/D regions were formed prior to depositing the SnO2 channel. This approach yielded stable channel modulation with an on/off ratio > 10(8), along with a significant enhancement in field-effect mobility, increasing from 10.4 to 25.3 cm(2)/Vs. Furthermore, the entire process was conducted at 400 degrees C or below, demonstrating its potential for enabling high-performance oxide transistors compatible with low temperature processes. | Kim, Seonchang; Kim, Huiseung; Park, Suhyeon; Lee, Dawon; Chung, Roy Byung Kyu | Kyungpook Natl Univ, Dept Adv Mat Sci & Engn, Daegu 41566, South Korea | 24071193200; 59654352300; 59655690400; 58569918600; 16642183100 | roy.b.chung@knu.ac.kr; | MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING | MAT SCI SEMICON PROC | 1369-8001 | 1873-4081 | 192 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 4.6 | 25.8 | 0 | 2025-05-07 | 0 | 0 | Atomic layer deposition; Fluorination; Selective-area doping; SnO2 | INTEGRATION | Atomic layer deposition; Fluorination; Selective-area doping; SnO<sub>2</sub> | Field effect transistors; Layered semiconductors; Semiconductor doping; Supersaturation; Atomic-layer deposition; Doping process; F-doping; Field-effect transistor; Fluorine doping; On-off ratio; Performance; Selective areas; Selective-area doping; SnO 2; Fluorination | English | 2025 | 2025-06-15 | 10.1016/j.mssp.2025.109421 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Enhancing the nonvolatile properties of sol-gel-processed Y2O3 RRAM devices by suppressing oxygen vacancy formation | In this study, Y2O3-based resistive random-access memory (RRAM) devices with an Ag/Y2O3/indium tin oxide structure are fabricated on a glass substrate via sol-gel processing. These Y2O3 RRAM devices demonstrate typical bipolar resistance-switching characteristics without requiring a high-voltage forming process. The presence of oxygen vacancies in the metal-oxide layers alters the electrical properties of these devices. To control the oxygen vacancy concentration, the post-annealing temperatures are varied between 300 and 500 degrees C. As this temperature increases, the concentration of formed oxygen vacancies decreases. The RRAM devices annealed at 500 degrees C feature a reduced number of oxygen vacancies in Y2O3, initially exhibiting the highest high-resistance state. This yields the highest high-to low-resistance state ratio exceeding 10(5). Moreover, the Y2O3 RRAM devices annealed at 500 degrees C exhibit the highest number of endurance cycles (similar to 10(3)) and good data-retention times (similar to 10(4) s). In addition, the reduced oxygen vacancy concentration in these annealed Y2O3 films suppresses the excessive formation of conductive filaments in the low-resistance state and decreases the leakage current in the high-resistance state. Overall, these changes yield a high-to low-resistance state ratio and improved endurance characteristics owing to the reduced oxygen vacancy concentration in the Y2O3 films annealed at 500 degrees C. | Lee, Sangwoo; Cho, Yoonjin; Heo, Seongwon; Choi, Suhyeon; Bae, Jin-Hyuk; Kang, In-Man; Kim, Kwangeun; Lee, Won-Yong; Jang, Jaewon | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Aerosp Univ, Sch Elect & Informat Engn, Goyang 10540, South Korea; Kyungpook Natl Univ, Inst Elect Technol, Daegu 41566, South Korea | Lee, Hyun Woo/AAH-8473-2020 | 58567753300; 58567567900; 58960360300; 59484230700; 35326180700; 7203062678; 36004977500; 57209527128; 57194107504 | yongsz@knu.ac.kr; j1jang@knu.ac.kr; | MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING | MAT SCI SEMICON PROC | 1369-8001 | 1873-4081 | 188 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 4.6 | 25.8 | 0 | 2025-05-07 | 1 | 1 | THIN-FILMS; DEPOSITION; MEMORY; BEHAVIOR; LAYER | Conductive films; Hard facing; Melt spinning; Oxygen vacancies; Random access storage; High-resistance state; High-to-low; Low-resistance state; Nonvolatile; Oxide structures; Oxygen vacancy concentration; Property; Random access memory; Sol'gel; Vacancy formation; Sol-gel process | English | 2025 | 2025-03-15 | 10.1016/j.mssp.2024.109241 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Resistive and photocurrent switching behaviors of a flexible VO2/mica device fabricated via laser ablation patterning | We fabricated flexible resistive and photocurrent switching devices based on VO2 films grown on a 3-mu m-thick mica substrate using a laser ablation patterning process, enabled by the unique thermal and electrical insulating properties of mica. We confirmed that the metal-insulator transition characteristics of the VO2 film grown on the mica substrate remained stable under outward and inward bending deformations, with curvature kappa ranging from +0.2 mm(-)(1) to -0.2 mm(-)(1). The flexible VO2 devices demonstrated stable and fast resistive switching performances even at low voltages. Additionally, the devices generated a photocurrent proportional to the light intensity at low bias voltages. Notably, we demonstrated that the photocurrent switching behavior of the flexible VO2 device can be adjusted using pulsed-voltage measurements. These results suggest that the flexible VO2/mica device, fabricated via a laser ablation patterning process, provides a cost-effective and straightforward approach for developing flexible VO2-based resistive memory and optoelectronic devices. | Kim, Han Gyeol; Kim, Deok Hun; Lee, Jehoon; Yeo, Junyeob; Dho, Joonghoe | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | Yeo, Junyeob/I-1287-2013 | 59506756500; 59506756600; 58150655100; 58692645200; 6602898623 | jhdho@knu.ac.kr; | MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING | MAT SCI SEMICON PROC | 1369-8001 | 1873-4081 | 189 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 4.6 | 25.8 | 2.6 | 2025-05-07 | 0 | 1 | vanadium dioxide; Flexible optoelectronic devices; Metal-insulator transition; Resistive switching | METAL-INSULATOR-TRANSITION; VO2 | : vanadium dioxide; Flexible optoelectronic devices; Metal-insulator transition; Resistive switching | Metal insulator boundaries; Metal insulator transition; Mott insulators; Photocurrents; Thick films; Vanadium dioxide; : vanadium dioxide; Flexible optoelectronic device; Flexible optoelectronics; Lasers ablations; Metal-insulators transitions; Mica substrates; Optoelectronics devices; Resistive switching; Switching behaviors; Vanadium dioxide; Laser ablation | English | 2025 | 2025-04 | 10.1016/j.mssp.2025.109276 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Assessing the Effect of Cytoreduction on Solitary, Resectable Lesions in Primary Central Nervous System Lymphoma | Background/Objectives: The management of primary central nervous system lymphoma (PCNSL) has traditionally prioritized diagnostic biopsy, with surgical resection often considered secondary due to risks and potential bias in previous studies, which included patients with deep or multiple tumors. This study aims to evaluate the impact of surgical resection on survival in patients with solitary, resectable PCNSL. Methods: We conducted a retrospective analysis of PCNSL patients treated via brain biopsy or surgical resection at our institution between January 2010 and December 2022. Cases with deep-located tumors (corpus callosum, basal ganglia, thalamus, and brainstem) or multiple lesions were excluded. Survival and clinical outcomes were compared between the two groups. Results: A total of 79 patients (30 resection and 49 biopsy) were included. No significant differences were observed between groups regarding demographics, comorbidities, tumor characteristics, or International Extranodal Lymphoma Study Group scores. Preoperative midline shifting (p = 0.048) and steroid use (p < 0.001) were higher in the resection group, which also demonstrated greater symptom improvement (p < 0.001). The complication rates were comparable between groups. The 5-year overall survival (OS) was 81.3% (resection) vs. 80.1% (biopsy), and the 5-year progression-free survival (PFS) was 53.6% (resection) vs. 60.3% (biopsy), with no significant differences in OS or PFS by Cox regression analysis. Conclusions: Surgical resection does not improve OS or PFS in solitary, resectable PCNSL, though it may provide symptomatic relief in select cases. Further prospective studies are needed to define its role in PCNSL management. | Lee, Chaejin; Byeon, Yukyeng; Kim, Gung Ju; Jeon, Juhee; Hong, Chang Ki; Kim, Jeong Hoon; Kim, Young-Hoon; Cho, Young Hyun; Hong, Seok Ho; Chong, Sang Joon; Song, Sang Woo | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol Surg, Seoul 05505, South Korea | Cho, Young/AAV-8697-2021 | 57211989339; 56183790500; 58905520300; 58906037300; 57208356870; 57201965829; 58304779800; 55472215500; 57203319535; 37664614800; 55104329100 | cjleee01@gmail.com; his4u2@hanmail.net; | CANCERS | CANCERS | 2072-6694 | 17 | 6 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-05-07 | 1 | 1 | primary central nervous system lymphoma; resection; remission; cytoreduction; clinical course | INTERNATIONAL EXTRANODAL LYMPHOMA; METHOTREXATE; MANAGEMENT; OUTCOMES; SURGERY; REGIMEN; PCNSL | clinical course; cytoreduction; primary central nervous system lymphoma; remission; resection | carboplatin; cyclophosphamide; cytarabine; dexamethasone; doxorubicin; etoposide; ifosfamide; methotrexate; prednisolone; procarbazine; rituximab; steroid; vincristine; adult; Article; biopsy; cancer chemotherapy; cancer recurrence; clinical outcome; cohort analysis; comorbidity; craniotomy; cytoreductive surgery; drug megadose; female; follow up; hemiparesis; human; Karnofsky Performance Status; lymphoma; major clinical study; male; needle biopsy; neurologic disease; nuclear magnetic resonance imaging; operative blood loss; outcome assessment; overall survival; pneumonia; postoperative complication; primary central nervous system lymphoma; progression free survival; radiation dose; retrospective study; stem cell transplantation; surgical infection; survival analysis; whole body radiation; wound healing impairment | English | 2025 | 2025-03-07 | 10.3390/cancers17060917 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development and External Validation of a Nomogram Predicting Early Recurrence of Gallbladder Cancer Using Preoperatively Available Prognosticators: A Korean Multicenter Retrospective Study | Background: Gallbladder cancer (GBC) is a rare and aggressive malignancy with poor prognosis and high recurrence rates, even after curative surgical resection. Early recurrence, defined as recurrence within one year after surgery, remains a major clinical concern. This study aimed to identify preoperative prognostic factors and develop a predictive model for early recurrence and overall survival in resected GBC patients. Methods: We retrospectively analyzed data from 251 patients who underwent curative-intent resection for GBC between 2008 and 2017. Logistic regression was used to identify preoperative factors associated with early recurrence. Significant variables were used to construct a nomogram, which was externally validated using a cohort of 176 patients from three independent tertiary centers. Results: The independent predictors of early recurrence included male sex, chronic liver disease, preoperative symptoms, elevated carcinoembryonic antigen (CEA), sarcopenic obesity, clinical T3 or higher stage, and suspected metastatic lymph nodes. The nomogram demonstrated strong predictive performance with an AUC of 0.872 (95% CI: 0.817-0.927) in internal validation and 0.703 (95% CI: 0.613-0.793) in external validation. Conclusions: We developed and externally validated a novel nomogram that predicts early recurrence in GBC using only preoperative factors. This model may support individualized risk assessment and aid surgeons and patients in shared decision-making prior to high-risk surgery. | Jeon, Hyun Jeong; Yoon, So Kyung; Park, Boram; Kim, Hyeong Seok; Chae, Hochang; Kim, Hongbeom; Shin, Sang Hyun; Han, In Woong; Heo, Jin Seok; Lee, Okjoo; Yoon, So Jeong | Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Div Hepatobiliary Pancreat Surg,Dept Surg, Daegu 41404, South Korea; Soonchunhyang Univ, Seoul Hosp, Coll Med, Dept Cardiol,Dept Surg, Seoul 04401, South Korea; Samsung Med Ctr, Res Inst Future Med, Biomed Stat Ctr, Seoul 06351, South Korea; Inha Univ, Coll Med, Incheon 22332, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Div Hepatobiliary Pancreat Surg,Sch Med, Seoul 06351, South Korea; Soonchunhyang Univ, Bucheon Hosp, Coll Med, Div Hepatobiliary Pancreat Surg,Dept Surg, Bucheon 14584, South Korea | 57266297900; 57219111681; 55629622000; 57221454343; 58694328200; 57103962000; 36109355100; 59682837300; 7102832040; 57222335728; 57219111679 | brpark@inha.ac.kr; hs0853.kim@samsung.com; 106254@schmc.ac.kr; sojeong.yoon@samsung.com; | CANCERS | CANCERS | 2072-6694 | 17 | 9 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-06-11 | 0 | 0 | gallbladder cancer; cholecystectomy; recurrence; nomogram | BILIARY-TRACT; RISK; CHOLECYSTECTOMY; GALLSTONES; PROGNOSIS | cholecystectomy; gallbladder cancer; nomogram; recurrence | bilirubin; CA 19-9 antigen; carcinoembryonic antigen; abdominal pain; adult; appendicular skeletal muscle mass index; area under the curve; Article; cancer prognosis; cancer recurrence; cancer staging; cholecystectomy; chronic liver disease; cohort analysis; computer assisted tomography; controlled study; decision making; diagnostic test accuracy study; excision; female; fever; follow up; gallbladder cancer; hepatitis; hepatopancreatoduodenectomy; human; intra-abdominal fat; major clinical study; male; middle aged; multicenter study; nomogram; nuclear magnetic resonance imaging; obesity; overall survival; positron emission tomography; predictive model; preoperative evaluation; receiver operating characteristic; recurrence free survival; retrospective study; sarcopenia; sarcopenic obesity; sensitivity and specificity; tertiary care center; tumor volume; validation process | English | 2025 | 2025-04-26 | 10.3390/cancers17091450 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Recent Research on Role of p53 Family in Small-Cell Lung Cancer | Small-cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid proliferation, early metastasis, and frequent recurrence, which contribute to a poor prognosis. SCLC is defined by the near-universal inactivation of key tumor suppressor genes, notably TP53 and RB1, which play central roles in its pathogenesis and resistance to therapy. The p53 family of proteins, including p53, p63, and p73, is essential to maintaining cellular homeostasis and tumor suppression. TP53 mutations are almost ubiquitous in SCLC, leading to dysregulated apoptosis and cell cycle control. Moreover, p73 shows potential as a compensatory mechanism for p53 loss, while p63 has a minimal role in this cancer type. In this review, we explore the molecular and functional interplay of the p53 family in SCLC, emphasizing its members' distinct yet interconnected roles in tumor suppression, immune modulation, and therapy resistance. We highlight emerging therapeutic strategies targeting these pathways, including reactivating mutant p53, exploiting synthetic lethality, and addressing immune evasion mechanisms. Furthermore, this review underscores the urgent need for novel, isoform-specific interventions to enhance treatment efficacy and improve patient outcomes in this challenging disease. | Jeong, Minho; Kim, Kee-Beom | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, Sch Life Sci,KNU G LAMP Project Grp, Daegu 41566, South Korea | 59733357400; 59813848700 | kbk@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 17 | 7 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-05-07 | 0 | 0 | SCLC; tumor suppressor gene; p53; p63; p73 | SAM DOMAIN; P63; P73; GENE; INHIBITION; MUTATIONS; CARCINOMA; APOPTOSIS; TARGET; PANEL | p53; p63; p73; SCLC; tumor suppressor gene | protein p53; apoptosis; cancer inhibition; cell cycle regulation; drug therapy; human; immune evasion; immunomodulation; metastasis; mouse; nonhuman; review; small cell lung cancer; synthetic lethality; tumor suppressor gene | English | 2025 | 2025-03-26 | 10.3390/cancers17071110 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Resilience of tigecycline heteroresistance phenotype in Acinetobacter baumannii | Background: Heteroresistance, frequently observed in diverse bacterial species, imposes clinical challenges. For this study, we investigated the stability and resilience of tigecycline heteroresistance in Acinetobacter baumannii. Methods: Four tigecycline-heteroresistant (HR) A. baumannii strains and resistant populations (RPs) obtained from them were subjected to laboratory evolution assays for 30 days in antibiotic-free media. The heteroresistance phenotype was determined using a population analysis. Bacterial growth curves and in vitro competitiveness were determined to investigate the fitness cost of heteroresistance. Tigecycline efficacy was evaluated using an in vitro time–killing assay. Genetic mutations were identified using whole genome sequencing, and expression of genes in the two-component systems was also evaluated. Results: Tigecycline heteroresistance was preserved even in antibiotic-free media, and tigecycline-RPs reverted to heteroresistance during serial culture without tigecycline pressure. The tigecycline-RPs showed a higher fitness cost than their respective HR strains, and the HR strains exhibited a survival advantage upon tigecycline treatment. Although the AdeABC efflux pump was overexpressed in the tigecycline-RPs, it was down-regulated in the HR strains. Conclusions: Our data indicate that tigecycline heteroresistance is a highly resilient phenotype in A. baumannii that gives a high fitness advantage to bacteria in terms of competitiveness and response to antibiotic pressure. © The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. | Jo, Jeongwoo; Kim, Sun Ju; Kwon, Ki Tae; Ko, Kwan Soo | Department of Microbiology, School of Medicine, Sungkyunkwan University, Suwon, South Korea; Department of Pharmacy, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Microbiology, School of Medicine, Sungkyunkwan University, Suwon, South Korea | 57273699900; 57191360475; 9733850500; 7202689224 | ksko@skku.edu; | Journal of Antimicrobial Chemotherapy | J ANTIMICROB CHEMOTH | 0305-7453 | 1460-2091 | 80 | 2 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PHARMACOLOGY & PHARMACY | 2024 | 3.6 | 25.9 | 0 | 2025-05-07 | 0 | Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Drug Resistance, Bacterial; Genetic Fitness; Humans; Microbial Sensitivity Tests; Mutation; Phenotype; Tigecycline; Whole Genome Sequencing; tigecycline; antiinfective agent; tigecycline; Acinetobacter baumannii; Acinetobacter baumannii infection; antibiotic resistance; antibiotic sensitivity; Article; bacterial strain; bactericidal activity; comparative study; down regulation; drug efficacy; drug stability; gene expression profiling; gene mutation; genetic trait; genetic transcription; genotype; in vitro study; infection prevention; minimum inhibitory concentration; nonhuman; phenotype; population research; recurrent infection; survival; treatment failure; whole genome sequencing; Acinetobacter infection; drug effect; drug therapy; genetics; human; microbial sensitivity test; microbiology; mutation; reproductive fitness | English | Final | 2025 | 10.1093/jac/dkae436 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Role of Postoperative Radiotherapy in the Management of Localized Head and Neck Mucosal Melanoma | Background/Objectives: To evaluate the role of postoperative radiotherapy (PORT) in the management of localized head and neck mucosal melanoma (HNMM). Methods: We retrospectively reviewed 33 patients who underwent surgery for localized HNMM between 2006 and 2023. PORT was delivered to affected anatomical structures, and elective nodal irradiation was not performed. Treatment outcomes, including local recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS), were analyzed. Results: After surgery, 14 patients (41.4%) received PORT. During follow-up, 87.9% of patients experienced recurrence, with local and distant failures being the most common. PORT significantly improved LRFS (p = 0.047) but did not impact PFS or OS. PORT (HR 0.14, p = 0.005) and resection margin status (HR 8.71, p < 0.001) were significantly associated with LRFS in multivariable analysis. Conclusions: PORT for localized HNMM improved local control. Regional recurrence was rare (one patient, 3.4%) even though ENI was not performed. PORT without ENI could improve clinical outcomes for localized HNMM. | Bae, Bong Kyung; Sohn, Jin Ho; Ahn, Dongbin; Lee, Gil Joon; Kwak, Ji Hye; Park, Junhee; Lee, Jeong Eun | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Daegu 41944, South Korea | 57191481610; 55165818100; 44761055400; 59753631300; 57393330600; 57210104861; 57206732333 | bae8808@gmail.com; sohnjh@knu.ac.kr; godlikeu@naver.com; giljoon.lee@gmail.com; laugh112@naver.com; jhp1247@naver.com; jelee@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 17 | 8 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-05-07 | 0 | 0 | head and neck mucosal melanoma; postoperative radiotherapy; radiotherapy field; local control; survival | ADJUVANT RADIOTHERAPY | head and neck mucosal melanoma; local control; postoperative radiotherapy; radiotherapy field; survival | adult; aged; anatomical concepts; article; Article; cancer radiotherapy; cancer recurrence; cancer staging; clinical article; clinical outcome; clinical target volume; computer assisted tomography; controlled study; dermatitis; disease activity; distant metastasis; elective nodal irradiation; ethmoid sinus; event free survival; face, nose and sinuses; female; follow up; human; intensity modulated radiation therapy; irradiation; Kaplan Meier method; left maxillary sinus; local recurrence free survival; localized head and neck mucosal melanoma; male; maxillary sinus; mucosa inflammation; mucosal melanoma; nose cavity; oropharynx; overall survival; positron emission tomography-computed tomography; postoperative period; progression free survival; retrospective study; salvage therapy; simultaneous integrated boost technique; surgical margin; thickness; treatment failure; treatment outcome; tumor localization | English | 2025 | 2025-04-10 | 10.3390/cancers17081284 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Tipping the ultrafast photochemical balance of cis-stilbene | Multi-state nonadiabatic molecular dynamics simulations combined with MRSF-TDDFT have revealed that the quantum yield of photoproducts in cis-stilbene is dependent on the initial temperature of the ground state, thereby resolving controversies regarding the competition between isomerization and ring-closure reactions. Specifically, 4,4-dihydrophenanthrene (DHP) is preferentially formed at low temperatures, while trans-stilbene is favored at high temperatures. The ethylenic torsional motions (theta) are particularly coupled with the initial thermal condition, tipping the balance of the competition. | Farmani, Maryam; Park, Woojin; Lee, Seunghoon; Choi, Cheol Ho | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea | 58054703700; 57223952329; 57194591254; 57940570600 | cchoi@knu.ac.kr; | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | PHOTOCH PHOTOBIO SCI | 1474-905X | 1474-9092 | 24 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS;CHEMISTRY, PHYSICAL | 2024 | 3.2 | 25.9 | 0 | 2025-06-11 | 0 | 0 | Photoisomerization; Stilbene; MRSF-TDDFT; NAMD | S-1 TRANS-STILBENE; EXCITED-STATE; AB-INITIO; PHOTOISOMERIZATION; DYNAMICS; ISOMERIZATION; TEMPERATURE; DEPENDENCE; FLUORESCENCE; SPECTROSCOPY | MRSF-TDDFT; NAMD; Photoisomerization; Stilbene | Association reactions; Photolysis; Photopolymerization; Photosynthesis; Quantum yield; stilbene; Cis-stilbene; Dynamics simulation; MRSF-TDDFT; Multi-state; NAMD; Nonadiabatic molecular dynamics; Photochemicals; Photoisomerizations; Stilbene; Ultra-fast; article; controlled study; high temperature; isomerization; low temperature; mechanical torsion; molecular dynamics; photobiology; photochemistry; quantum yield; temperature; Photoisomerization | English | 2025 | 2025-06 | 10.1007/s43630-025-00737-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | WBP5 Expression Influences Prognosis and Treatment Response in Head and Neck Squamous Cell Carcinoma | Objectives: Head and neck squamous cell carcinoma (HNSCC) is characterized by complex genetic alterations. This study aimed to identify WBP5 as a promising therapeutic target and evaluate the effect of WBP5 expression on prognosis and treatment response in HNSCC. Methods: Publicly available datasets were comprehensively analyzed to investigate WBP5 expression through comprehensive bioinformatics analysis and functional validation. Results: WBP5 was particularly overexpressed in HNSCC, as analyzed through the Gene Expression Profiling Interactive Analysis version 2 (GEPIA2) database and validated using multiple Gene Expression Omnibus (GEO) datasets. Analysis with UALCAN confirmed that WBP5 expression was significantly higher in advanced cancer stages and tumor grades than that of normal samples. A Kaplan-Meier analysis demonstrated that patients overexpressing WBP5 had a poor prognosis. Moreover, WBP5 expression correlated with the overexpression of the epidermal growth factor receptor in HNSCC. In vitro experiments revealed that WBP5 knockdown significantly reduced FaDu cell proliferation and viability. Furthermore, silencing WBP5 enhanced cisplatin sensitivity, indicating its potential role in chemoresistance. Conclusions: These results indicate that WBP5 could act as a prognostic marker and a viable therapeutic target in HNSCC. Modulating WBP5 expression may represent a novel strategy to enhance treatment efficacy. Future studies should elucidate the precise mechanisms of WBP5 action and develop targeted therapies. This integrated approach, combining a comprehensive analysis of publicly available datasets with in vitro experimental validation provides strong evidence for the clinical significance of WBP5 in HNSCC. | Jeong, Eun-jeong; Kim, Eunjeong; Jung, Kwang-Yoon; Baek, Seung-Kuk; Kim, Yeon Soo | Konyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Daejeon 35365, South Korea; Korea Univ Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 02841, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea | 57205177104; 56892981600; 7402479624; 7201371667; 57207443122 | 602547@kyuh.ac.kr; eunjkim@knu.ac.kr; kyjung@korea.ac.kr; mdbsk@korea.ac.kr; ionskim@korea.ac.kr; | CANCERS | CANCERS | 2072-6694 | 17 | 4 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-05-07 | 0 | 0 | head and neck squamous cell carcinoma; WW domain-binding protein 5 (WBP5); Transcriptional Elongation Factor A-like 9 (TCEAL9) | GENE-EXPRESSION; CANCER; CHEMOTHERAPY; BIOMARKERS; CETUXIMAB; TRIALS | head and neck squamous cell carcinoma; Transcriptional Elongation Factor A-like 9 (TCEAL9); WW domain-binding protein 5 (WBP5) | cisplatin; crystal violet; epidermal growth factor receptor; penicillin derivative; pyruvate sodium; reagent; streptomycin; advanced cancer; apoptosis; Article; bioinformatics; cell infiltration; cell proliferation; controlled study; data base; differential gene expression; FaDu cell line; female; fetal bovine serum; gene expression; head and neck squamous cell carcinoma; human; human cell; human experiment; human tissue; immunocompetent cell; immunohistochemistry; information processing; Kaplan Meier method; major clinical study; male; microarray analysis; natural killer T cell; normal human; overall survival; prognosis; protein expression; RNA sequence; statistical analysis; survival analysis; survival rate; treatment response; tumor growth; upregulation | English | 2025 | 2025-02 | 10.3390/cancers17040587 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Amygdalin Alleviates Atopic Dermatitis-Like Skin Inflammation via Inhibition of Th2 Immune Response | Won, Seon-bin; Kim, Sang-hyun | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | J PHARMACOL EXP THER | 0022-3565 | 1521-0103 | 392 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.8 | 26.0 | 0 | Atopic dermatitis; Amygdalin; Skin inflammation; T helper 2 lymphocyte; Keratinocyte | English | 2025 | 2025-03 | 10.1016/j.jpet.2024.100682 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | Meeting Abstract | Esculetin Inhibits Mast Cell-Mediated Allergic Inflammation and Anaphylaxis by Suppressing the FcRI Signaling Pathway | Kim, Daheen; Jeong, Seungwon; Lee, Soyoung; Kim, Sang-Hyun | Kyungpook Natl Univ, Daegu 41944, South Korea; Kyungpook Natl Univ, Daegu 41566, South Korea | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | J PHARMACOL EXP THER | 0022-3565 | 1521-0103 | 392 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.8 | 26.0 | 0 | Esculetin; Allergic inflammation; Mast cells; Histamine | English | 2025 | 2025-03 | 10.1016/j.jpet.2024.100683 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | Meeting Abstract | Protectin D1 from ω-3 Fatty Acids Suppresses Mast Cell-Mediated Allergic Responses via FcεRI-Mediated Signaling | Yoon, Jieun; Jeong, Seungwon; Lee, Soyoung; Kim, Sang-hyun | Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Daegu 41566, South Korea | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | J PHARMACOL EXP THER | 0022-3565 | 1521-0103 | 392 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.8 | 26.0 | 0 | protectin D1; allergic inflammation; mast cell; omega-3 fatty acid; DHA | English | 2025 | 2025-03 | 10.1016/j.jpet.2024.100691 | 바로가기 | 바로가기 | 바로가기 |
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