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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Article ⓘ Pronounced Light Insensitivity in Low-Voltage n-Channel Organic Field-Effect Transistors with Channel Layers of Dinitrobenzothiadiazole-Containing Conjugated Polymer ⓘ A light insensitivity in organic field-effect transistors (OFETs) is crucial for use under ambient light conditions that can cause additional current flow in devices leading to unexpected noises. Here, we report low-voltage driving n-channel OFETs, featuring very low light sensitivity, with a channel layer consisting of dinitrobenzothiadiazole-containing conjugated polymer, poly[{2,5-bis(2-octyldodecyl)-3,6-bis(thien-2-yl)-pyrrolo[3,4-c]pyrrole-1,4-diyl}-co-{2,2′-(5,6-dinitro-2,1,3-benzothiadiazole)-5,5′-diyl}] (PODTPPD-DNBT). The PODTPPD-DNBT polymer, synthesized via the Stille reaction of two comonomers, showed an optical absorption up to 1100 nm and a lowest unoccupied molecular orbital (LUMO) energy of 4.41 eV. The OFET devices with the PODTPPD-DNBT channels exhibited n-channel-mode transistor behaviors at a low voltage (≤5 V) and very slightly increased drain current under illumination with strong near-infrared (NIR, wavelength = 905 nm, intensity = 5.96 mW/cm2) and simulated solar light (intensity = 100 mW/cm2). The PODTPPD-DNBT channel layers delivered very low photoresponsivity of 6.95 mA/W under the NIR light, which is less than 1% compared to the theoretical maximum value of 730 mA/W, and 2800% lower photoresponsivity (0.3 mA/W) compared to the same backbone polymer (PODTPPD-BT) without dinitro groups under the simulated solar light. © 2024 American Chemical Society. ⓘ Son, Youjeong; Kim, Taehoon; Kim, Hwajeong; Kim, Youngkyoo ⓘ Organic Nanoelectronics Laboratory, KNU Institute for Nanophotonics Applications (KINPA), Department of Chemical Engineering, Kyungpook National University, Daegu, 41566, South Korea, Department of Energy Convergence & Climate Change, Institute for Global Climate Change and Energy, Kyungpook National University, Daegu, 41566, South Korea; Organic Nanoelectronics Laboratory, KNU Institute for Nanophotonics Applications (KINPA), Department of Chemical Engineering, Kyungpook National University, Daegu, 41566, South Korea; Organic Nanoelectronics Laboratory, KNU Institute for Nanophotonics Applications (KINPA), Department of Chemical Engineering, Kyungpook National University, Daegu, 41566, South Korea, Priority Research Center, Research Institute of Environmental Science & Technology, Kyungpook National University, Daegu, 41566, South Korea; Organic Nanoelectronics Laboratory, KNU Institute for Nanophotonics Applications (KINPA), Department of Chemical Engineering, Kyungpook National University, Daegu, 41566, South Korea, Department of Energy Convergence & Climate Change, Institute for Global Climate Change and Energy, Kyungpook National University, Daegu, 41566, South Korea ⓘ ⓘ 59492397600; 57218650958; 15520531700; 10340424400 ⓘ ykimm@knu.ac.kr; ⓘ ACS Applied Electronic Materials ⓘ ACS APPL ELECTRON MA ⓘ N/A 2637-6113 7 1 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 4.7 25.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ dinitrobenzothiadiazole; light insensitivity; low voltage; n-channel; n-type conjugated polymer; organic field-effect transistors ⓘ Elastomers; Ionomers; Light sensitive materials; Molecular orbitals; Organic field effect transistors; Silicones; Surface discharges; Ambient light; Channel layers; Dinitrobenzothiadiazole; Light insensitivity; Low voltages; N-channel; N-type conjugated polymer; Organic field-effect transistors; Photoresponsivity; Simulated solar light; Conjugated polymers ⓘ English Final 2025 10.1021/acsaelm.4c01473 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice ⓘ Sarcopenia, closely associated with other diseases such as diabetes, metabolic syndrome, and osteoporosis, significantly impacts aging populations. It is characterized by muscle atrophy, increased intramuscular adipose tissue, impaired myogenesis, chronic low-grade inflammation, and reduced muscle function. The mechanisms behind aging muscle remain incompletely understood. This study aims to elucidate the role of Sirt2 in the aging process of skeletal muscles and enhance our understanding of the underlying mechanisms. Sirt2 expression was reduced in aging muscle of male mice by 40%, compared to young muscle. Aged male Sirt2 knockout mice exhibit increased intramuscular adipose tissue infiltration by 8.5-fold changes. Furthermore, the deletion of Sirt2 exacerbated myogenesis impairment in aged muscle by decreasing the expression of Pax7 (50%) and NogoA (80%), compared to age- and sex- matched counterparts, emphasizing the role of Sirt2 in pathology of aging muscle. Additionally, long-term Sirt2 deletion affected other Sirtuin subfamily members, with decreased expressions of Sirt1 (65%), Sirt4 (94%), and Sirt5 (71%), and increased expressions of Sirt6 (4.6-fold) and Sirt7 (2.8-fold) in old male Sirt2 knockout mice, while there was no difference of these gene expression in young male mice. This study underscores the critical need for a deeper investigation into Sirt2, promising new insights that could lead to targeted therapies for sarcopenia, ultimately improving the quality of life in the elderly. ⓘ Lee, Eun-Joo; Park, Sunyoung; Jeong, Kyu-Shik ⓘ Kyungpook Natl Univ, Coll Vet Med, Dept Pathol, Daegu 41566, South Korea; Daegu Haany Univ, Dept Compan Anim Hlth, Gyongsan 38610, South Korea; Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA; Stellamed Co LTD, Daegu 41504, South Korea ⓘ Jeong, Kyu-Shik/D-6740-2011 ⓘ 58363110000; 57085459500; 7201556460 ⓘ elee22@bidmc.harvard.edu; sunnypark78@gmail.com; jeongks@knu.ac.kr; ⓘ BIOGERONTOLOGY ⓘ BIOGERONTOLOGY ⓘ 1389-5729 1573-6768 26 3 SCIE GERIATRICS & GERONTOLOGY ⓘ 2024 4.1 25.3 0 2025-05-07 ⓘ 0 0 Sirt2; Aging; Skeletal muscle; Sarcopenia; Intramuscular adipose tissue infiltration; Myogenesis ⓘ SKELETAL-MUSCLE; PROTEIN SIR2; INFLAMMATION; DEACETYLASE; SARCOPENIA ⓘ Aging; Intramuscular adipose tissue infiltration; Myogenesis; Sarcopenia; Sirt2; Skeletal muscle ⓘ Adipose Tissue; Aging; Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Development; Muscle, Skeletal; Sarcopenia; Sirtuin 2; MyoD protein; protein Nogo A; sirtuin 1; sirtuin 2; sirtuin 4; sirtuin 5; sirtuin 6; sirtuin 7; transcription factor PAX7; Sirt2 protein, mouse; sirtuin 2; adult; age; aged; aging; animal experiment; Article; controlled study; diabetes mellitus; disease association; drug targeting; elderly care; gene deletion; gene expression; intramuscular fat; knockout mouse; male; metabolic syndrome X; middle aged; mouse; muscle atrophy; muscle development; muscle disease; muscle function; nonhuman; osteoporosis; protein deficiency; protein expression; protein family; quality of life; sarcopenia; sex difference; young adult; adipose tissue; animal; C57BL mouse; genetics; metabolism; pathology; physiology; sarcopenia; skeletal muscle ⓘ English 2025 2025-06 10.1007/s10522-025-10238-7 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Structural controls on hydrocarbon migration traced from direct hydrocarbon indicators at the southwestern margin of the Ulleung Basin, East Sea ⓘ This study presents a model for structural controls on hydrocarbon migration under the neotectonic regime at the southwestern margin of the Ulleung Basin in the East Sea, a marginal basin in the western Pacific. Based on comprehensive 3D multichannel seismic reflection and well data, we map the fault system and direct hydrocarbon indicators, including seismic chimneys and bright spots, at depths shallower than 1000 ms TWT (1144 m). We analyze the slip tendency of the 3D fault system based on current stress conditions newly estimated using focal mechanism data. Our results show that dextral strike-slip movements of NE-SW Group A faults, resulting in damage zones composed of subsidiary NW-SE to E-W Group B faults at tips and stepover zones, mainly accommodate the neotectonic deformation. The distribution of hydrocarbon indicators demonstrates spatial correlations with the fault system, indicating deformation-induced hydrocarbon migration and accumulation patterns. We emphasize that (1) along-fault zones and (2) releasing stepover zones of NE-SW Group A faults with a high tendency to slip have acted as main hydrocarbon migration pathways and accumulation zones. In addition, we suggest that trishear fault-related folding in a local transpression zone (the Gorae V anticline) can generate a forelimb with a high density of sub-seismic scale fracture corridors acting as active hydrocarbon pathways. Our findings increase the understanding of neotectonic deformation-induced hydrocarbon migration/ accumulation patterns in the southwestern margin of the Ulleung Basin, contributing to assessment of hydrocarbon prospects, carbon dioxide capture and storage (CCS) opportunities, and submarine geohazards in western Pacific marginal basins with a similar tectonic setting. ⓘ Lee, Kang Hyeon; Park, Seung-Ik; Kim, Inho; Jun, Hyunggu; Lee, Junho; Kang, Nyeon-Keon; Smeraglia, Luca ⓘ Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Korea Inst Geosci & Mineral Resources, Geol Res Ctr, Daejeon 34132, South Korea; Korea Natl Oil Corp, E&P Domest Business Dept, Ulsan 44538, South Korea; Korea Inst Geosci & Mineral Resources, Petr Energy Res Ctr, Daejeon 34132, South Korea; CNR, IGAG, Rome, Italy ⓘ Smeraglia, Luca/HKO-7843-2023 ⓘ 59458678800; 55832472000; 57208922381; 59769212000; 58619565000; 54786465600; 56458848300 ⓘ psi@knu.ac.kr; ⓘ MARINE AND PETROLEUM GEOLOGY ⓘ MAR PETROL GEOL ⓘ 0264-8172 1873-4073 173 SCIE GEOSCIENCES, MULTIDISCIPLINARY ⓘ 2024 3.6 25.4 0 2025-05-07 ⓘ 0 0 Neotectonic strike-slip faulting; Slip tendency; Hydrocarbon migration; Direct hydrocarbon indicator; Ulleung basin ⓘ BACK-ARC BASIN; SHALLOW GAS ACCUMULATIONS; ARTIFICIAL NEURAL-NETWORK; SOUTHERN YANGSAN FAULT; JAPAN SEA; STRIKE-SLIP; FLUID-FLOW; EVOLUTION; STRESS; TECTONICS ⓘ Direct hydrocarbon indicator; Hydrocarbon migration; Neotectonic strike-slip faulting; Slip tendency; Ulleung basin ⓘ Pacific Ocean; Pacific Ocean (West); Sea of Japan; Ulleung Basin; Fault slips; Seismic prospecting; Submarine geophysics; Direct hydrocarbon indicators; Fault system; Hydrocarbon migration; Marginals; Neotectonic strike-slip faulting; Neotectonics; Slip tendency; Strike slip faulting; Structural control; Ulleung basin; hydrocarbon migration; marginal basin; neotectonics; strike-slip fault; structural control; tectonic setting; Strike-slip faults ⓘ English 2025 2025-03 10.1016/j.marpetgeo.2024.107222 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Synthesis of Five-Membered Heterocycle Fused Quinazolinone Via Buchwald-Hartwig Cross Coupling Reaction ⓘ Through the Buchwald-Hartwig cross-coupling reaction, we successfully coupled the 2 '-bromo five-membered heterocyclic ester derivative with the 2-aminopyridine derivative, and carried out an intramolecular cyclization reaction to synthesize quinazolinone derivatives with the substituted fived-membered heterocycle. Using Pd(OAc)2 as the catalyst and Xantphos ligand, we synthesized fived-membered heterocycle-fused quinazolinone derivatives with 23 different aminopyridines, as well as thiazole, imidazole, thiophene, pyrrole, and pyrazole, with yields from 7-99 %. To further expand the diversity of heterocyclic rings, we used mCPBA to oxidize the methylsulfide at the 2-position of thiazole to a sulfone group, and then optimized a desulfonative nucleophilic substitution reaction using a variety of nucleophiles. This allowed for the substitution of 11 nucleophiles, resulting in the construction of a library of 37 quinazolinone derivatives with substituted five-membered heterocycles. ⓘ Moon, Jimin; Lee, Hyojin; Lee, Taeho ⓘ Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ⓘ 59529084500; 59562877800; 57204032003 ⓘ tlee@knu.ac.kr; ⓘ ASIAN JOURNAL OF ORGANIC CHEMISTRY ⓘ ASIAN J ORG CHEM ⓘ 2193-5807 2193-5815 14 5 SCIE CHEMISTRY, ORGANIC ⓘ 2024 2.7 25.4 0 2025-05-07 ⓘ 0 0 Buchwald-Hartwig reaction; thiazole; heterocycle; one-pot reaction; cascade-reaction ⓘ SOLID-PHASE SYNTHESIS; DERIVATIVES; DMF ⓘ Buchwald–Hartwig reaction; cascade-reaction; heterocycle; one-pot reaction; thiazole ⓘ ⓘ English 2025 2025-05 10.1002/ajoc.202400795 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Natural Inhibitor, 1′S-1′-Acetoxychavicol Acetate, Against Testosterone-Induced Alopecia via NADPH Oxidase Regulation ⓘ Androgenetic alopecia is associated with testosterone-mediated anagen-to-catagen transition and matrix keratinocyte apoptosis in hair follicle cells. Activation of Nox isozymes is involved in testosterone-mediated keratinocyte apoptosis, leading to androgenetic alopecia. This indicates that Nox isozymes can serve as therapeutic targets for androgenetic alopecia. The isolated compounds from natural products were screened to evaluate their ROS-inhibition efficacy and it was found that 1 ' S-1 '-acetoxychavicol acetate (ACA, 26), a natural compound isolated from Alpinia galanga (L.) Willd. (Zingiberaceae), exhibits inhibitory activity on Nox isozymes. Nox inhibition by ACA suppressed testosterone-dependent H2O2 generation and cell death in keratinocytes. Incubation with ACA in human hair follicle organ culture mitigated testosterone-dependent suppression of hair growth. We validated that ACA regulates androgenetic alopecia in a mouse model. Local application of ACA on the dorsal skin in an androgenetic alopecia model of C57BL/6 mice significantly suppressed testosterone-induced hair loss in a dose-dependent manner. Moreover, hair follicle length in ACA-treated mice was enhanced compared to that in control mice. These findings provide a molecular mechanism in which ACA inhibits Nox activity in hair follicle cells, indicating its potential as an effective treatment of AGA. ⓘ Park, Kkotnara; Youn, Isoo; Suh, Jung Min; Choi, Min Hye; Bae, Da-Woon; Park, Soo-Bong; Kwack, Mi Hee; Cha, Sun-Shin; Jang, Dae Sik; Sung, Young Kwan; Bae, Yun Soo; Seo, Eun Kyoung ⓘ Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea; Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu 41566, South Korea; Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Sci, Seoul 02447, South Korea ⓘ Jang, Dae/AAI-4526-2020 ⓘ 56387885300; 57221999006; 57209793932; 59517644200; 57197825656; 59878948700; 59915047000; 7201864593; 7102794507; 55663365300; 15031067200; 7005953758 ⓘ baeys@ewha.ac.kr; yuny@ewha.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 10 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 0 2025-06-11 ⓘ 0 0 reactive oxygen species; NADPH oxidase; Nox inhibitor; 1 'S-1 '-acetoxychavicol acetate; androgenetic alopecia ⓘ HAIR-GROWTH; OXIDATIVE STRESS; PROMOTES; GPRC6A ⓘ 1′S-1′-acetoxychavicol acetate; androgenetic alopecia; NADPH oxidase; Nox inhibitor; reactive oxygen species ⓘ Alopecia; Alpinia; Animals; Apoptosis; Benzyl Alcohols; Biological Products; Disease Models, Animal; Enzyme Inhibitors; Hair Follicle; Humans; Hydrogen Peroxide; Keratinocytes; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Reactive Oxygen Species; Testosterone; 1'-acetoxychavicol acetate; benzyl alcohol derivative; biological product; enzyme inhibitor; hydrogen peroxide; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; testosterone; alopecia; Alpinia; animal; apoptosis; C57BL mouse; chemistry; disease model; drug effect; drug therapy; hair follicle; human; keratinocyte; male; metabolism; mouse; pathology ⓘ English 2025 2025-05-21 10.3390/molecules30102246 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Correction ⓘ Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model (vol 25, 4755, 2020) ⓘ ⓘ Saba, Evelyn; Kim, Seung-Hyung; Lee, Yuan Yee; Kim, Hyun-Kyoung; Roh, Seong-Soo; Kwak, Yi-Seong; Park, Chae-Kyu; Kim, Sung-Dae; Rhee, Man Hee ⓘ Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon 34520, South Korea; Seowon Univ, Dept Food Sci & Engn, Chungbuk 28674, South Korea; Daegu Haany Univ, Coll Korean Med, Daegu 42158, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon 34520, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 46033, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Rawalpindi 46000, Pakistan ⓘ Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016; Saba, Evelyn/JLN-1878-2023; Kim, Seung-Hyung/AAA-4707-2020 ⓘ 56721112000; 54383305300; 57203798815; 55791359100; 12752302700; 36868130200; 55885553100; 55156746000; 57211035357 ⓘ evelyn.saba@uaar.edu.pk; sksh518@dju.kr; yuanyeelee@knu.ac.kr; kimhk4@seowon.ac.kr; ddede@dhu.ac.kr; twostar@kgc.or.kr; ckpark@kgc.co.kr; sdkim@dirams.co.kr; rheemh@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 6 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 0 2025-05-07 ⓘ 0 0 ⓘ ⓘ ⓘ adult; erratum; mouse; nonhuman ⓘ English 2025 2025-03-10 10.3390/molecules30061229 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Anti-Thrombotic Activity of 3-Deoxysappanchalcone via Inhibiting Platelet Aggregation and Thrombin (FIIa)/Activated Factor X (FXa) Activity ⓘ Naturally occurring plant-based compounds are increasingly being explored for their therapeutic potential in treating a wide range of conditions, particularly those related to vascular health. The compound 3-deoxysappanchalcone (3-DSC), derived from Caesalpinia sappan L., has been proven to exhibit anti-inflammatory, anti-influenza, and anti-allergic properties, though its role in thrombosis and haemostasis remains unexplored. This study aimed to evaluate the anti-thrombotic potential of 3-DSC in both in vitro and in vivo models. The anticoagulant activities of 3-DSC were assessed using activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin (FIIa) and activated factor X (FXa) activity assays, as well as fibrin polymerization and platelet aggregation tests. Its effects on plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) expression were evaluated in TNF-alpha-stimulated human umbilical vein endothelial cells (HUVECs). The results demonstrated that 3-DSC extended aPTT and PT, suppressed thrombin and FXa activities, reduced their production in HUVECs, inhibited thrombin-induced fibrin polymerization and platelet aggregation, and exerted anticoagulant effects in mice. Furthermore, 3-DSC significantly decreased the PAI-1 to t-PA ratio. These findings suggest that 3-DSC possesses potent anti-thrombotic properties by modulating coagulation pathways and fibrinolysis. Its therapeutic potential warrants further investigation for the development of novel anticoagulant agents. ⓘ Han, Gyuri; Lee, Jinhee; Bae, Jong-Sup ⓘ Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, CMRI, Daegu 41566, South Korea ⓘ ⓘ 59912983300; 59150416200; 16021543200 ⓘ f11074@naver.com; aadd8563@gmail.com; baejs@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 12 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 ⓘ 0 0 Caesalpinia sappan L.; 3-deoxysappanchalcone; anti-thrombotic activity; fibrinolysis ⓘ VEIN ENDOTHELIAL-CELLS; PLASMINOGEN-ACTIVATOR; CAESALPINIA-SAPPAN; TYPE-1; ANTICOAGULANTS; OLD ⓘ 3-deoxysappanchalcone; anti-thrombotic activity; Caesalpinia sappanL; fibrinolysis ⓘ ⓘ English 2025 2025-06-13 10.3390/molecules30122580 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Green Extraction of Antioxidant-Rich Flavonoids from Fagonia cretica Using Deep Eutectic Solvents ⓘ This study optimized the extraction of flavonoids from Fagonia cretica using deep eutectic solvents (DESs), focusing on key factors such as the type of DES used, molar ratio, water content, solid/liquid ratio, extraction temperature, and time. Among six DESs tested, the betaine-acetic acid combination exhibited the highest extraction efficiency, attributed to its low viscosity (4.98 mPas). Optimal extraction conditions were determined to be a 1:4 molar ratio of betaine to acetic acid, a 25% water content, a solid/liquid ratio of 1:60 g/mL, an extraction temperature of 50 degrees C, and an extraction time of 30 min. Under these conditions, the flavonoid yield was maximized while preserving bioactivity. Antioxidant assays revealed that flavonoids extracted with DESs exhibited superior scavenging activity against DPPH and hydroxyl radical compared to ethanol-extracted flavonoids, highlighting DESs' potential to enhance antioxidant properties. The recyclability of DESs was demonstrated using ultracapacitor porous activated carbon, achieving an 89.78% recovery efficiency. The reused DES maintained a high flavonoid extraction yield, retaining 92% efficiency after six cycles, emphasizing its sustainability and cost-effectiveness. This study establishes DES-based extraction as an environmentally friendly and efficient approach for isolating flavonoids with strong antioxidant properties, offering significant advantages in green chemistry and bioactive compound recovery. ⓘ Khan, Jafar; Asaf, Sajjad; Lubna, Ashraf M. M.; Abdelbacki, Ashraf M. M.; Jan, Rahmatullah; Kim, Kyung-Min ⓘ Northeast Forestry Univ, Key Lab Forest Plant Ecol, Harbin 150040, Peoples R China; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; King Saud Univ, Deanship Skills Dev, POB 2455, Riyadh 11451, Saudi Arabia; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea ⓘ Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Abdelbacki, Ashraf/ABF-3628-2021; Asaf, Sajjad/ABA-3647-2021 ⓘ 57215502708; 56595059900; 57200621537; 35723565200; 57201981969; 34868260300 ⓘ sajadasif2000@gmail.com; lubnabilal68@gmail.com; aabdelbacki@ksu.edu.sa; rahmat2021@knu.ac.kr; kkm@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 4 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 0 2025-05-07 ⓘ 2 1 antioxidant activity; deep eutectic solvents; flavonoid extraction; Fagonia cretica; sustainable recovery ⓘ BUCKWHEAT; DENSITY ⓘ antioxidant activity; deep eutectic solvents; Fagonia cretica; flavonoid extraction; sustainable recovery ⓘ Antioxidants; Deep Eutectic Solvents; Flavonoids; Green Chemistry Technology; Plant Extracts; Zygophyllaceae; antioxidant; deep eutectic solvent; flavonoid; plant extract; chemistry; green chemistry; isolation and purification; Zygophyllaceae ⓘ English 2025 2025-02 10.3390/molecules30040813 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition ⓘ Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (Ln2O3) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodisperse Ln2O3 nanoparticles (Ln = Eu, Gd, and Tb) via thermal decomposition in oleylamine at 280 degrees C, followed by ligand exchange with citric acid (CA) to produce water-dispersible, CA-grafted Ln2O3 nanoparticles with high colloidal stability. The resulting CA-grafted Ln2O3 nanoparticles had average diameters of approximately 2 nm. We characterized their physicochemical properties, including in vitro cytotoxicity, magnetic resonance imaging properties (i.e., water proton spin relaxivities), and X-ray imaging properties (i.e., X-ray attenuation). ⓘ Liu, Shuwen; Tegafaw, Tirusew; Ho, Son Long; Yue, Huan; Zhao, Dejun; Liu, Ying; Mulugeta, Endale; Chen, Xiaoran; Lee, Hansol; Ahn, Dabin; Yang, Ji-ung; Park, Ji Ae; Baek, Ahrum; Kim, Jihyun; Chang, Yongmin; Lee, Gang Ho ⓘ Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Div Biomed Sci, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul 01817, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Taegu 41944, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Chem Educ, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu 41944, South Korea ⓘ Beza, Endale/D-6211-2017; Ho, Son Long/P-3183-2015 ⓘ 57208926248; 55983618600; 55659242700; 57200329016; 57222567792; 57221731093; 57199654704; 59938916200; 59299461900; 58679951200; 57212217968; 59760966200; 57194601711; 56954528100; 7501840633; 7404851841 ⓘ liushuwen0701@gmail.com; tirukorea@gmail.com; sonlongh@gmail.com; yuehuan888@gmail.com; djzhao.chem@gmail.com; ly1124161@gmail.com; endexindex05@gmail.com; tsukiyovo@gmail.com; leehs9836@naver.com; adb9504@naver.com; wjy11300@kirams.re.kr; jpark@kirams.re.kr; baxun@naver.com; jkim23@knu.ac.kr; ychang@knu.ac.kr; ghlee@mail.knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 12 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 ⓘ 0 0 lanthanide oxide nanoparticle; thermal decomposition; ligand exchange; imaging properties; magnetic resonance imaging; X-ray imaging ⓘ SOFT ACIDS; GD2O3 NANOPARTICLES; CONTRAST AGENTS; LN(2)O(3) LN; BASES HSAB; IN-VITRO; MR; CT; COMPLEXES; HARD ⓘ imaging properties; lanthanide oxide nanoparticle; ligand exchange; magnetic resonance imaging; thermal decomposition; X-ray imaging ⓘ ⓘ English 2025 2025-06-09 10.3390/molecules30122519 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Pectin-Based Active and Smart Film Packaging: A Comprehensive Review of Recent Advancements in Antimicrobial, Antioxidant, and Smart Colorimetric Systems for Enhanced Food Preservation ⓘ This review provides a comprehensive overview of recent advancements in biodegradable active and smart packaging utilizing pectin from various origins for food applications. It critically examines the challenges and limitations associated with these developments, initially focusing on the structural influences of pectin on the properties of packaging films. Methods such as spray drying, casting, and extrusion are detailed for manufacturing pectin films, highlighting their impact on film characteristics. In discussing active pectin films, the review emphasizes the effectiveness of incorporating essential oils, plant extracts, and nanoparticles to enhance mechanical strength, moisture barrier properties, and resistance to oxidation and microbial growth. Smart biodegradable packaging is a significant research area, particularly in monitoring food freshness. The integration of natural colorants such as anthocyanins, betacyanins, and curcumin into these systems is discussed for their ability to detect spoilage in meat and seafood products. The review details the specific mechanisms through which these colorants interact with food components and environmental factors to provide visible freshness indicators for consumers. It underscores the potential of these technologies to fulfill sustainability goals by providing eco-friendly substitutes for traditional plastic packaging. ⓘ Said, Nurul Saadah; Lee, Won Young ⓘ Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea ⓘ Lee, Wonyoung/AAL-2780-2021; Said, Nurul Saadah/LFV-3208-2024 ⓘ 57211398275; 57195940408 ⓘ nurulsaadah.said@gmail.com; wonyoung@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 5 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 1.94 2025-05-07 ⓘ 5 5 pectin film; active packaging; smart packaging; antioxidant; antimicrobe; color indicator ⓘ PHYSICOCHEMICAL PROPERTIES; MECHANICAL-PROPERTIES; ESSENTIAL OIL; BY-PRODUCTS; SHELF-LIFE; STABILITY; EXTRUSION; EXTRACTION; CURCUMIN; BARRIER ⓘ active packaging; antimicrobe; antioxidant; color indicator; pectin film; smart packaging ⓘ Anti-Infective Agents; Antioxidants; Colorimetry; Food Packaging; Food Preservation; Pectins; antiinfective agent; antioxidant; pectin; chemistry; colorimetry; food packaging; food preservation; procedures ⓘ English 2025 2025-03 10.3390/molecules30051144 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Phytosterols: Extraction Methods, Analytical Techniques, and Biological Activity ⓘ Phytosterols, essential components of plant cell membranes, are abundant in fruits, vegetables, nuts, and seeds. Among them, beta-sitosterol, campesterol, and stigmasterol have drawn significant interest for their well-documented biological activities. This review highlights recent advancements in extraction and analytical methods aimed at improving phytosterol yield, maintaining chemical stability, and reducing environmental impact. These innovative, eco-friendly techniques offer promising alternatives to traditional extraction approaches and hold potential for industrial-scale use. Phytosterols possess various bioactive properties, including antioxidant, anti-inflammatory, chemopreventive, cholesterol-lowering, and neuroprotective effects. Through these mechanisms, dietary phytosterols may help prevent cardiovascular and neurodegenerative diseases, type 2 diabetes, and certain cancers. Recent studies have focused on the identification, isolation, purification, and characterization of phytosterols from diverse food matrices, along with assessing their health benefits. However, the specific molecular pathways responsible for their pharmacological actions remain poorly understood, highlighting the need for further research, particularly in human clinical trials. This review provides a comprehensive overview of the extraction strategies, biological functions, and mechanisms of action of phytosterols, offering valuable insights for developing phytosterol-enriched functional foods and nutraceuticals. ⓘ Yoon, Byoung-Hoon; Truong, Van-Long; Jeong, Woo-Sik ⓘ Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea ⓘ Jeong, Woo-Sik/AAN-6885-2020 ⓘ 58641373600; 59962803000; 10440750200 ⓘ byounghoon97@naver.com; truonglongpro@gmail.com; wsjeong@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 12 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 ⓘ 0 0 phytosterols; extraction methods; analytical techniques; biological activities ⓘ SOLID-PHASE EXTRACTION; MICROWAVE-ASSISTED EXTRACTION; PLANT STEROLS; BETA-SITOSTEROL; LIQUID-CHROMATOGRAPHY; CHOLESTEROL; DERIVATIZATION; OIL; LDL; HYPERCHOLESTEROLEMIA ⓘ analytical techniques; biological activities; extraction methods; phytosterols ⓘ ⓘ English 2025 2025-06-06 10.3390/molecules30122488 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Standardized spinal MRI protocol: diagnosing spontaneous intracranial hypotension and correlating with brain MRI ⓘ Purpose: To evaluate a standardized cervical-thoracic-lumbar (CTL) contrast-enhanced (CE)-MRI protocol for spinal findings in spontaneous intracranial hypotension (SIH) and their correlation with brain MRI. Methods: This retrospective study included SIH-suspected patients who underwent spine MRI from March 2019 to February 2023. Diagnosis was based on clinical criteria, using a 3T MRI with a standardized spine protocol. MRI diagnostic criteria included spinal (e.g., spinal longitudinal epidural fluid collection [SLEC], dural enhancement [DE]) and brain findings (four qualitative methods including venous sinus engorgement [VSE], pachymeningeal enhancement [PE], and brain sagging [BS] as confirmatory diagnostic criteria; and four quantitative methods). Patients were classified into Group 1 (brain MRI-positive showing VSE, PE or BS) and Group 2 (brain MRI-negative). Demographics and MRI findings were compared in both groups using t-tests or chi-square statistics. Results: Among 53 SIH patients, 42 with spine MRI-positive findings underwent brain MRI (mean age 43.95 ± 12.26 years, 66.7% female), with 27 in Group 1 and 15 in Group 2. Group 1 demonstrated significantly wider sagittal and axial extents of SLEC (full range: 85.2%, circumferential: 82.1%; p < 0.001, p = 0.011), and a higher prevalence of the C1-2 sign, while Group 2 exhibited these features less frequently (85.2% vs. 53.3%, p = 0.024). Brain MRI findings in Group 1 included VSE (92.6%), PE (66.7%), and BS (7.4%), with subdural fluid collection also higher (37.0%, p = 0.007). Other brain parameters showed no significant differences. Conclusion: The standardized CTL CE-MRI protocol enables comprehensive SIH diagnosis, when brain MRI findings are negative or equivocal. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. ⓘ Yoon, Yu Sung; Khil, Eun Kyung; Jo, Sang Won; Lee, Seun Ah; Cho, Soo-Jin ⓘ School of Medicine, Kyungpook National University, Daegu, South Korea, Department of Radiology, Kyungpook National University Hospital, Daegu, South Korea; Department of Radiology, Fastbone Orthopedic Hospital, Hwaseong, South Korea, Department of Radiology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea; Department of Radiology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea; Department of Radiology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea; Department of Neurology, Hallym University Dontan Sacred Heart Hospital, Hwaseong, South Korea ⓘ ⓘ 57414392900; 56019764100; 57203368124; 57212606557; 35386173500 ⓘ nizzinim@gmail.com; ⓘ European Spine Journal ⓘ EUR SPINE J ⓘ 0940-6719 1432-0932 SCIE CLINICAL NEUROLOGY;ORTHOPEDICS ⓘ 2024 2.7 25.5 0 2025-06-11 ⓘ 0 ⓘ ⓘ Brain; Cerebrospinal fluid; Intracranial hypotension; Magnetic resonance imaging; Spine ⓘ ⓘ English Article in press 2025 10.1007/s00586-025-08973-z ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Temperature Uniformity Control of 12-Inch Semiconductor Wafer Chuck Using Double-Wall TPMS in Additive Manufacturing ⓘ In semiconductor inspection equipment, a chuck used to hold a wafer is equipped with a cooling or heating system for temperature uniformity across the surface of the wafer. Surface temperature uniformity is important for increasing semiconductor inspection speed. Triply periodic minimal surfaces (TPMSs) are proposed to enhance temperature uniformity. TPMSs are a topic of increasing research in the field of additive manufacturing and are a type of metamaterial inspired by nature. TPMSs are periodic surfaces with no intersections. Their continuous curve offers self-support during the additive manufacturing process. This structure enables the division of a single space into two domains. As a result, the heat transfer area per unit volume is larger than that of general lattice structures, leading to a superior heat transfer performance. This paper proposes a new structure called a double-wall TPMS. The process of creating a double-walled TPMS by adjusting the thickness of the sheet TPMS was investigated, and its thermal performance was studied. Finally, a double-wall TPMS was applied to the chuck. The optimal designs for the diamond and gyroid structures exhibited a difference in surface temperature uniformity of 0.23 degrees C and 0.66 degrees C, respectively. Accordingly, the models optimized with the double-wall TPMS are proposed. ⓘ Park, Sohyun; Lee, Jaewook; Lee, Seungyeop; Sung, Jihyun; Jung, Hyungug; Lee, Ho; Kim, Kunwoo ⓘ Korea Inst Ind Technol, Daegyung Technol Applicat Div, Daegu Si 42994, South Korea; Kyungpook Natl Univ, Dept Smart Mobil Engn, Daegu Si, South Korea; Staco Co Ltd, Siheung Si, South Korea; Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, Daegu Si 41566, South Korea ⓘ ; Lee, Seungyeop/MYR-2664-2025 ⓘ 59315132600; 59510648900; 57260442700; 23482644100; 58101030100; 26660670700; 35169979000 ⓘ hyunypark@kitech.re.kr; jaewk95@knu.ac.kr; sylee94@kitech.re.kr; jsung@kitech.re.kr; hgjung@staco.kr; holee@knu.ac.kr; kwkim@kitech.re.kr; ⓘ MATERIALS ⓘ MATERIALS ⓘ 1996-1944 18 1 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2024 3.2 25.5 0 2025-05-07 ⓘ 0 0 wafer probe chuck; temperature uniformity; additive manufacturing; double-wall TPMS; thermo-fluid CFD analysis ⓘ ⓘ additive manufacturing; double-wall TPMS; temperature uniformity; thermo-fluid CFD analysis; wafer probe chuck ⓘ Cooling systems; Heating equipment; Inspection; Inspection equipment; CFD analysis; CFD analyzes; Double wall; Double-wall triply periodic minimal surface; Temperature uniformity; Thermo fluids; Thermo-fluid CFD analyze; Triply periodic minimal surfaces; Wafer probe chuck; Wafer probes; Chucks ⓘ English 2025 2025-01 10.3390/ma18010211 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives ⓘ A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe-Ziegler and cyclization reactions. The thiazolo[4,5-d]pyrimidin-7(6H)-one derivative library with a diversity of three had a total of four synthesis steps and 57 compounds. In addition, the yield per synthesis step was 65-97%, which was very high. The developed synthesis method and compounds will be used to find compounds with biological activity through the thiazole derivative structure-activity relationship. ⓘ Hua, Shuanghui; Moon, Jimin; Lee, Taeho ⓘ Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80 Daehak Ro, Daegu 702701, South Korea ⓘ ⓘ 59528942300; 59529084500; 57204032003 ⓘ huashuanghui@naver.com; ace_goh@naver.com; tlee@knu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 2 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 0 2025-05-07 ⓘ 0 0 thiazole; solid-phase synthesis; chemical library ⓘ DESIGN ⓘ chemical library; solid-phase synthesis; thiazole ⓘ pyrimidinone derivative; thiazole; thiazole derivative; article; biological activity; combinatorial library; controlled study; cyclization; drug analysis; drug development; nonhuman; pharmacology; solid phase synthesis; structure activity relation; synthesis ⓘ English 2025 2025-01 10.3390/molecules30020430 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Therapeutic Potential of Myricitrin in a db/db Mouse Model of Type 2 Diabetes ⓘ Type 2 diabetes is characterized by insulin resistance, which contributes to dysregulated glucose and lipid metabolism and is associated with chronic inflammation. While previous studies have examined the effects of myricitrin in streptozotocin-induced diabetic models, its impact on the db/db mouse, a model that better reflects insulin resistance-associated metabolic disturbances, remains unclear. In this study, mice were divided into three groups (db/+, db/db, and db/db + 0.02% myricitrin) and were fed their respective diets for five weeks. Myricitrin supplementation reduced fat mass, adipocyte size, and plasma leptin levels, which were elevated in db/db mice. Although myricitrin did not affect fasting blood glucose levels, it lowered plasma insulin, hemoglobin A1c, postprandial glucose levels, and the homeostasis model assessment of insulin resistance, suggesting improvements in insulin sensitivity and glucose homeostasis. Enhanced pancreatic insulin expression, along with reduced hepatic gluconeogenic enzyme activities and mRNA expression, contributed to the improved glucose homeostasis observed in myricitrin-supplemented mice. Additionally, myricitrin reduced hepatic triglyceride levels and lipid droplet accumulation by inhibiting hepatic fatty acid synthase activity. It also decreased plasma inflammatory marker levels and their mRNA expression in adipose tissue. These findings suggest that myricitrin may be a promising therapeutic candidate for type 2 diabetes. ⓘ Kim, Sang Ryong; Kim, Young-Je; Kim, Hwicheol; Park, Sojeong; Jung, Un Ju ⓘ Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 FOUR KNU Creat Biores Grp, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso Ro, Busan 48513, South Korea ⓘ ⓘ 56486163800; 55571346800; 59551696100; 59552240200; 7007119425 ⓘ srk75@knu.ac.kr; breezy750@naver.com; k423897@naver.com; impark-sj@naver.com; jungunju@pknu.ac.kr; ⓘ MOLECULES ⓘ MOLECULES ⓘ 1420-3049 30 7 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY ⓘ 2024 4.6 25.5 0 2025-05-07 ⓘ 0 0 myricitrin; db/db mice; insulin resistance; hepatic steatosis; inflammation ⓘ INSULIN-RESISTANCE; ADIPOSE-TISSUE; HEPATIC STEATOSIS; LIVER; BETA; EXPRESSION; OBESITY; ANTIOXIDANT; SENSITIVITY; ACTIVATION ⓘ db/db mice; hepatic steatosis; inflammation; insulin resistance; myricitrin ⓘ Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Flavonoids; Insulin; Insulin Resistance; Leptin; Lipid Metabolism; Liver; Male; Mice; flavonoid; insulin; leptin; myricitrin; adipose tissue; animal; blood; disease model; drug effect; drug therapy; experimental diabetes mellitus; glucose blood level; insulin resistance; lipid metabolism; liver; male; metabolism; mouse; non insulin dependent diabetes mellitus; pathology ⓘ English 2025 2025-03-25 10.3390/molecules30071460 ⓘ 바로가기 바로가기 바로가기 바로가기
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