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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Optogenetic Control of Dopamine Receptor 2 Reveals a Novel Aspect of Dopaminergic Neurotransmission in Motor Function ⓘ Dopaminergic neurotransmission plays a crucial role in motor function through the coordination of dopamine receptor (DRD) subtypes, such as DRD1 and DRD2, thus the functional imbalance of these receptors can lead to Parkinson's disease. However, due to the complexity of dopaminergic circuits in the brain, it is limited to investigating the individual functions of each DRD subtype in specific brain regions. Here, we developed a light-responsive chimeric DRD2, OptoDRD2, which can selectively activate DRD2-like signaling pathways with spatiotemporal resolution. OptoDRD2 was designed to include the light-sensitive component of rhodopsin and the intracellular signaling domain of DRD2. Upon illumination with blue light, OptoDRD2 triggered DRD2-like signaling pathways, such as G alpha i/o subtype recruitment, a decrease in cAMP levels, and ERK phosphorylation. To explore unknown roles of DRD2 in glutamatergic cell populations of basal ganglia circuitry, OptoDRD2 was genetically expressed in excitatory neurons in lateral globus pallidus (LGP) of the male mouse brain. The optogenetic stimulation of OptoDRD2 in the LGP region affected a wide range of locomotion-related parameters, such as increased frequency of movement and decreased immobility time, resulting in the facilitation of motor function of living male mice. Therefore, our findings indicate a potentially novel role for DRD2 in the excitatory neurons of the LGP region, suggesting that OptoDRD2 can be a valuable tool enabling the investigation of unknown roles of DRD2 at specific cell types or brain regions. ⓘ Kim, Hyunbin; Park, Geunhong; Shin, Hyo Geun; Kwon, Duwan; Kim, Heejung; Baek, In-Yeop; Nam, Min-Ho; Cho, Il-Joo; Kim, Jeongjin; Seong, Jihye ⓘ Korea Inst Sci & Technol, Brain Sci Inst, Seoul 02792, South Korea; Seoul Natl Univ, Dept Pharmacol, Coll Med, Seoul 03080, South Korea; Seoul Natl Univ, Neurosci Res Inst, Med Res Inst, Coll Med, Seoul 03080, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Seoul Natl Univ, Dept Biomed Sci, Coll Med, Seoul 03080, South Korea; Kyung Hee Univ, Dept KHU KIST Convergence Sci & Technol, Seoul 02447, South Korea; Korea Univ, Dept Convergence Med, Seoul 02841, South Korea; Korea Univ, Coll Med, Dept Anat, Seoul 02841, South Korea; Univ Sci & Technol, Div Biomed Sci & Technol, Daejeon 34113, South Korea; Seoul Natl Univ, Interdisciplinary Program Neurosci, Seoul 08826, South Korea ⓘ ; Nam, Min-Ho/AAF-4287-2020; Cho, Il-Joo/AAP-6876-2020 ⓘ 57194192909; 57200395966; 56591066700; 59502895100; 56610997900; 57572909900; 54957031200; 7102561882; 37087302800; 24475969900 ⓘ jeongjin@kist.re.kr; jihye.seong@snu.ac.kr; ⓘ JOURNAL OF NEUROSCIENCE ⓘ J NEUROSCI ⓘ 0270-6474 1529-2401 45 1 SCIE NEUROSCIENCES ⓘ 2024 4 25.0 0 2025-05-07 ⓘ 1 1 dopamine receptor 2; lateral globus pallidus (LGP); motor function; OptoDRD2; optogenetics ⓘ BASAL GANGLIA; MOLECULAR DIVERSITY; STRUCTURAL INSIGHTS; ACTION INITIATION; INDIRECT PATHWAYS; NEURON ACTIVITY; PROTEIN; LOCALIZATION; TRANSMISSION; SELECTIVITY ⓘ dopamine receptor 2; lateral globus pallidus (LGP); motor function; OptoDRD2; optogenetics ⓘ Animals; Dopamine; Globus Pallidus; Humans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Optogenetics; Receptors, Dopamine D2; Synaptic Transmission; dopamine 2 receptor; dopamine; DRD2 protein, mouse; animal experiment; animal model; Article; bioluminescence resonance energy transfer; cell viability assay; controlled study; cytotoxicity; dopaminergic transmission; electronic spreadsheet; fluorescence intensity; glutamatergic signaling; HEK293-A cell line; human; human cell; illumination; immunohistochemistry; lateral globus pallidus; live cell imaging; locomotion; male; motor performance; mouse; nonhuman; open field test; optogenetics; protein phosphorylation; Western blotting; animal; C57BL mouse; genetics; globus pallidus; metabolism; motor activity; physiology; procedures; synaptic transmission ⓘ English 2025 2025-01-01 10.1523/jneurosci.1473-24.2024 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Potency of Lacticaseibacillus paracasei as an alternative to antibiotic growth promoter in broiler chicken challenged with avian pathogenic Escherichia coli ⓘ Background and Aim: The emergence of antibiotic-resistant bacteria due to the widespread use of antibiotic growth promoters (AGPs) necessitates the exploration of sustainable alternatives in poultry production. This study evaluated the efficacy of Lacticaseibacillus paracasei as a probiotic alternative to AGPs in broilers challenged with avian pathogenic Escherichia coli (APEC), with a focus on growth performance, antioxidant status, lipid metabolism, and hematological profiles. Materials and Methods: A total of 80 broiler chickens were randomly allocated into four groups: T0 (uninfected control), T1 (APEC-infected control), T2 (APEC + AGP, 0.1% zinc bacitracin), and T3 (APEC + probiotic, 0.5% L. paracasei). Treatments were administered from day 15 to 35 post-hatch, following a 2-week adaptation period. Performance indicators (feed conversion ratio [FCR], body weight gain [BWG], and feed efficiency [FE]), antioxidant parameters (superoxide dismutase [SOD] and malondialdehyde [MDA]), lipid profiles (cholesterol, HDL, and LDL), and hematological variables were assessed. Data were analyzed using analysis of variance with significance set at p < 0.05. Results: Probiotic supplementation significantly improved FCR, BWG, and FE (p < 0.05), with the T3 group achieving the most favorable outcomes. SOD activity was markedly higher, and MDA levels were reduced in probiotic-treated birds compared with the AGP and infected groups. Moreover, L. paracasei administration resulted in significant reductions in total cholesterol and LDL levels while maintaining moderate HDL concentrations. Hemoglobin and thrombocyte levels were modestly influenced, though overall hematological profiles remained stable across groups. © Lokapirnasari, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) ⓘ Lokapirnasari, Widya Paramita; Maslachah, Lilik; Saputro, Amung Logam; Rokana, Efi; Yulianto, Andreas Berny; Rosyada, Zulfi Nur Amrina; Firdaus, Muhammad Aviv; Silfia, Himatul Ilma; Lisnanti, Ertika Fitri; Baihaqi, Zein Ahmad; Marbun, Tabita Dameria; Khairullah, Aswin Rafif; Shakeel, Muhammad ⓘ Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, East Java, Surabaya, 60115, Indonesia; Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, East Java, Surabaya, 60115, Indonesia; Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Jl. Wijaya Kusuma No.113, Mojopanggung, Giri, East Java, Banyuwangi, 68425, Indonesia; Division of Animal Husbandry, Faculty of Agriculture, Universitas Islam Kadiri, Jl. Sersan Suharmaji No.38, Manisrenggo, Kota, East Java, Kediri, 64128, Indonesia; Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Jl. Dukuh Kupang XXV No.54, Dukuh Kupang, Dukuh Pakis, East Java, Surabaya, 60225, Indonesia; Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, East Java, Surabaya, 60115, Indonesia; Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, East Java, Surabaya, 60115, Indonesia; Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, East Java, Surabaya, 60115, Indonesia; Division of Animal Husbandry, Faculty of Agriculture, Universitas Islam Kadiri, Jl. Sersan Suharmaji No.38, Manisrenggo, Kota, East Java, Kediri, 64128, Indonesia; Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Jl. Raya Bogor, Km. 46 Cibinong, West Java, Bogor, 16911, Indonesia; Animal Nutrition Laboratory, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, Sangju, 37224, South Korea; Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Jl. Raya Bogor, Km. 46 Cibinong, West Java, Bogor, 16911, Indonesia; Faculty of Veterinary and Animal Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Shamsabad, Muree Road, Punjab, 46000, Pakistan ⓘ ⓘ 56576444100; 57195102840; 57211229270; 59175482800; 56576431600; 57204778199; 58568938600; 59519030300; 57216620095; 57193844875; 57219851669; 57212026505; 57209179360 ⓘ widya-p-l@fkh.unair.ac.id; ⓘ Veterinary World ⓘ VET WORLD ⓘ 0972-8988 2231-0916 18 5 ESCI AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2 25.0 0 2025-06-11 ⓘ 0 ⓘ ⓘ ⓘ alanine aminotransferase; alkaline phosphatase; antibiotic agent; antioxidant; bacitracin; bacitracin zinc; cholesterol; growth promotor; hemoglobin; high density lipoprotein cholesterol; low density lipoprotein; malonaldehyde; probiotic agent; superoxide dismutase; zinc; antibiotic resistance; antioxidant activity; Article; avian pathogenic Escherichia coli; bacterial growth; body growth; body weight; body weight gain; brachial vein; broiler; colony forming unit; Escherichia coli; food intake; Gallus gallus; gene expression; jugular vein; Lactobacillus paracasei; lipid fingerprinting; lipid metabolism; lipid peroxidation; nonhuman; oxidative stress; public health ⓘ English Final 2025 10.14202/vetworld.2025.1180-1189 ⓘ 바로가기 바로가기 바로가기
○ ○ Review ⓘ Unlocking the secrets of single extracellular vesicles by cutting-edge technologies ⓘ Extracellular vesicles (EVs), isolated through techniques such as liquid biopsy, have emerged as crucial biomarkers in various diseases, including cancer. EVs were dismissed initially as cellular debris, EVs are now recognized for their role in intercellular communication, carrying proteins, RNAs, and other molecules between cells. Their stability in biofluids and ability to mirror their parent cells' molecular composition make them attractive candidates for non-invasive diagnostics. EVs, including microvesicles and exosomes, contribute to immune modulation and cancer progression, presenting both therapeutic challenges and opportunities. However, despite advances in analytical techniques like high-resolution microscopy and nanoparticle tracking analysis (NTA), standardization in EV isolation and characterization remains a hurdle. Cutting-edge technologies, such as atomic force microscopy and Raman tweezers microspectroscopy, have enhanced our understanding of single EVs, yet issues like low throughput and high technical complexity limit their widespread application. Other technologies like transmission electron microscopy, cryogenic transmission electron microscopy, superresolution microscopy, direct stochastic optical reconstruction microscopy, single-molecule localization microscopy, tunable resistive pulse sensing, single-particle interferometric reflectance imaging sensor, flow cytometry, droplet digital analysis, total internal reflection fluorescence also contribute to EV analysis. Future research must focus on improving detection methods, developing novel analytical platforms, and integrating artificial intelligence to enhance the specificity of EV characterization. The future of EV research holds promise for breakthroughs in precision medicine, with a collaborative effort needed to translate these advancements into clinical practice. ⓘ Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Ghosh, Subhrojyoti; Nagarajan, ArulJothi Kandasamy; Batabyal, Rijula; Ahn, Byeong-Cheol ⓘ Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Indian Inst Technol, Dept Biotechnol, Chennai 600036, India; SRM Inst Sci & Technol, Dept Genet Engn, Chengalpattu 603203, Tamil Nadu, India; Heritage Inst Technol, Dept Biotechnol, Kolkata 700107, India; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea ⓘ Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021; Ghosh, Subhrojyoti/KDN-2006-2024 ⓘ 57195318729; 54393130400; 58035427200; 59503384300; 58757942600; 59527540200 ⓘ abc2000@knu.ac.kr; ⓘ PATHOLOGY RESEARCH AND PRACTICE ⓘ PATHOL RES PRACT ⓘ 0344-0338 1618-0631 269 SCIE PATHOLOGY ⓘ 2024 3.2 25.0 0 2025-05-07 ⓘ 0 1 Extracellular vesicles; Biomarkers; Cancer diagnostics; Intercellular communication; Precision medicine ⓘ MICROSCOPY; MICRORNAS; DELIVERY; ALLOWS; RNA ⓘ Biomarkers; Cancer diagnostics; Extracellular vesicles; Intercellular communication; Precision medicine ⓘ Animals; Extracellular Vesicles; Humans; Liquid Biopsy; Neoplasms; animal; diagnosis; exosome; human; liquid biopsy; metabolism; neoplasm; pathology; procedures ⓘ English 2025 2025-05 10.1016/j.prp.2025.155878 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Biotechnological advances in plant growth-promoting rhizobacteria for sustainable agriculture ⓘ The rhizosphere, the soil zone surrounding plant roots, serves as a reservoir for numerous beneficial microorganisms that enhance plant productivity and crop yield, with substantial potential for application as biofertilizers. These microbes play critical roles in ecological processes such as nutrient recycling, organic matter decomposition, and mineralization. Plant growth-promoting rhizobacteria (PGPR) represent a promising tool for sustainable agriculture, enabling green management of crop health and growth, being eco-friendly alternatives to replace chemical fertilizers and pesticides. In this sense, biotechnological advancements respecting genomics and gene editing have been crucial to develop microbiome engineering which is pivotal in developing microbial consortia to improve crop production. Genome mining, which involves comprehensive analysis of the entire genome sequence data of PGPR, is crucial for identifying genes encoding valuable bacterial enzymes and metabolites. The CRISPR-Cas system, a cutting-edge genome-editing technology, has shown significant promise in beneficial microbial species. Advances in genetic engineering, particularly CRISPR-Cas, have markedly enhanced grain output, plant biomass, resistance to pests, and the sensory and nutritional quality of crops. There has been a great advance about the use of PGPR in important crops; however, there is a need to go further studying synthetic microbial communities, microbiome engineering, and gene editing approaches in field trials. This review focuses on future research directions involving several factors and topics around the use of PGPR putting special emphasis on biotechnological advances. ⓘ Argentel-Martinez, Leandris; Penuelas-Rubio, Ofelda; Herrera-Sepulveda, Angelica; Gonzalez-Aguilera, Jorge; Sudheer, Surya; Salim, Linu M.; Lal, Sunaina; Pradeep, Chittethu Kunjan; Ortiz, Aurelio; Sansinenea, Estibaliz; Hathurusinghe, Sandamali Harshani Kumari; Shin, Jae-Ho; Babalola, Olubukola Oluranti; Azizoglu, Ugur ⓘ Tecnol Nacl Mexico, Inst Tecnol Valle Yaqui, Bacum 85260, Sonora, Mexico; Univ Estadual Mato Grosso Do Sul UEMS, Dept Agron, Cassilandia, MS, Brazil; Univ Tartu, Inst Ecol & Earth Sci, Dept Bot, EE-51005 Tartu, Estonia; Kerala Univ Fisheries & Ocean Studies, Fac Fisheries, Cochin, Kerala, India; Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok, Sikkim, India; Jawaharlal Nehru Trop Bot Garden & Res Inst, Microbiol Div, Thiruvananthapuram 695562, Kerala, India; Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla 72570, Puebla, Mexico; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; North West Univ, Fac Nat & Agr Sci, Food Secur & Safety Focus Area, Private Bag X2046, Mmabatho, South Africa; Kayseri Univ, Safiye Cikrikcioglu Vocat Coll, Dept Crop & Anim Prod, Kayseri, Turkiye; Erciyes Univ, Genome & Stem Cell Res Ctr, Kayseri, Turkiye ⓘ Peñuelas-Rubio, Ofelda/GQB-5410-2022; Sansinenea, Estibaliz/M-6871-2019; Sudheer, Surya/AAJ-2215-2021; Azizoglu, Ugur/ABC-7831-2020; Argentel, Leandris/AAQ-7171-2021; Babalola, Olubukola/Y-7564-2019 ⓘ 57202038750; 57194395312; 55900877800; 55307469600; 56526884300; 59495137700; 57221234814; 6603543312; 55989784200; 56013605400; 58931546900; 57224125922; 36166570300; 52363128100 ⓘ oleinismora@gmail.com; azizogluugur@hotmail.com; ⓘ WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY ⓘ WORLD J MICROB BIOT ⓘ 0959-3993 1573-0972 41 1 SCIE BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 4.2 25.1 1.67 2025-05-07 ⓘ 1 2 Microbial biotechnology; Plant-microbe interaction; Rhizospheric microbiome; Plant growth-promoting rhizobacteria (PGPR); Microbiome engineering; Gene editing ⓘ CRISPR-CAS; SOIL; SYSTEM ⓘ Gene editing; Microbial biotechnology; Microbiome engineering; Plant growth-promoting rhizobacteria (PGPR); Plant–microbe interaction; Rhizospheric microbiome ⓘ Agriculture; Bacteria; Biotechnology; CRISPR-Cas Systems; Crops, Agricultural; Gene Editing; Genetic Engineering; Microbiota; Plant Development; Plant Roots; Rhizosphere; Soil Microbiology; Fertilizers; Microorganisms; Biotechnological advances; Gene editing; Microbial biotechnology; Microbiome; Microbiome engineering; Plant growth-promoting rhizobacteria; Plant growth-promoting rhizobacterium; Plant-microbe interactions; Rhizospheric microbiome; agriculture; bacterium; biotechnology; classification; CRISPR Cas system; crop; gene editing; genetic engineering; genetics; growth, development and aging; metabolism; microbiology; microflora; plant development; plant root; procedures; rhizosphere; Gene encoding ⓘ English 2025 2025-01 10.1007/s11274-024-04231-4 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment ⓘ Endophytes have significant prospects for applications beyond their existing utilization in agriculture and the natural sciences. They form an endosymbiotic relationship with plants by colonizing the root tissues without detrimental effects. These endophytes comprise several microorganisms, including bacteria and fungi. They act as repositories of compounds of medicinal importance. They are considered sources of pigments besides synthetic dyes and assist with soil fertility and plant growth as bio-fertilizers. They also have immense potential for advanced technology using endophyte-synthesized nanoparticles. In assisting bioremediation, they facilitate detoxification of pollutants in all spheres of the environment. Studies on the potential of endophytic microbes in drug discovery and biotic stress management are underway. In this review, published databases on endophytes and their diverse roles and applications in various fields, such as bio-fertilizers and nanoparticles, as well as bioremediation, are critically discussed while exploring unanswered questions. In addition, future perspectives on endosymbiotic microorganisms and their prospective use in plants, environmental management, and medicine are discussed in this review. ⓘ Panwar, Anjali; Manna, Suvendu; Sahini, Gayatri; Kaushik, Vivek; Kumar, Manoj; Govarthanan, Muthusamy ⓘ Univ Petr, Sch Hlth Sci & Technol, Dept Microbiol & Energy Studies, Dehra Dun 248007, India; Univ Petr, Sch Adv Engn & Energy Studies, Sustainabil Cluster, Dehra Dun 24800, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Saveetha Univ, Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll & Hosp, Dept Biomat, Chennai 600077, Tamil Nadu, India ⓘ Muthusamy, Govarthanan/C-1491-2014 ⓘ 59224317000; 35885832600; 59528005800; 59526493200; 59404287900; 54881927600 ⓘ smanna@ddn.upes.ac.in; ⓘ WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY ⓘ WORLD J MICROB BIOT ⓘ 0959-3993 1573-0972 41 2 SCIE BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 4.2 25.1 0 2025-05-07 ⓘ 0 0 Bioactive agents; Bioremediation; Biofertilizers; Endophytes; Nanoparticles ⓘ FUNGUS PHOMOPSIS-LIQUIDAMBARI; PLANT-GROWTH; ANTIBACTERIAL; L.; PHYTOCHEMICALS; GIBBERELLINS; ANTIOXIDANT; CHALLENGES ⓘ Bioactive agents; Biofertilizers; Bioremediation; Endophytes; Nanoparticles ⓘ Bacteria; Biodegradation, Environmental; Endophytes; Fertilizers; Fungi; Nanoparticles; Pigments, Biological; Plants; Soil Microbiology; Symbiosis; Bacteria; Drug discovery; Fertilizers; Plant diseases; fertilizer; nanoparticle; pigment; Advanced technology; Bioactive agents; Biofertilizers; Endophyte; Endosymbiotic; Plant growth; Root tissues; Soil fertility; Synthesised; Synthetic dyes; bacterium; bioremediation; chemistry; endophyte; fungus; metabolism; microbiology; plant; symbiosis; Detoxification ⓘ English 2025 2025-02 10.1007/s11274-025-04265-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Co-carriage of blaNDM-1 and blaVIM-2 in different plasmids of Acinetobacter junii isolate and the transfer of blaNDM-1-carrying plasmids to Gram-negative bacteria ⓘ Carbapenem-resistant Acinetobacter junii isolate co-carried blaVIM-2 and blaNDM-1 in different plasmids. blaNDM-1- and blaVIM-2-carrying plasmids were characterized using the whole genome sequencing. The expression of blaNDM-1 was higher than that of blaVIM-2. blaNDM-1-carrying plasmid was conjugally transferred to various Gram-negative bacterial species. The transferability of blaNDM-1-carrying plasmid raises concerns about the potential spread of carbapenem resistance across diverse bacterial populations. © 2025 ⓘ Rana, Md Shohel; Kim, Shukho; Ko, Seo Yeon; Kim, Nayeong; Kim, Seong Yeob; Lee, Da Eun; Kwon, Ki Tae; Kim, Yu Kyung; Lee, Je Chul ⓘ Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Untreatable Infectious Disease Institute, Kyungpook National University, Daegu, 41944, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Kyungpook National University Hospital National Culture Collection for Pathogens (KNUH-NCCP), Kyungpook National University Hospital, Daegu, 41944, South Korea; Untreatable Infectious Disease Institute, Kyungpook National University, Daegu, 41944, South Korea, Kyungpook National University Hospital National Culture Collection for Pathogens (KNUH-NCCP), Kyungpook National University Hospital, Daegu, 41944, South Korea, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Untreatable Infectious Disease Institute, Kyungpook National University, Daegu, 41944, South Korea, Kyungpook National University Hospital National Culture Collection for Pathogens (KNUH-NCCP), Kyungpook National University Hospital, Daegu, 41944, South Korea, Department of Laboratory Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Untreatable Infectious Disease Institute, Kyungpook National University, Daegu, 41944, South Korea, Kyungpook National University Hospital National Culture Collection for Pathogens (KNUH-NCCP), Kyungpook National University Hospital, Daegu, 41944, South Korea ⓘ ⓘ 58735720500; 59820088300; 57959870800; 57211500281; 58290417200; 57224099074; 9733850500; 59840796100; 25930392000 ⓘ leejc@knu.ac.kr; ⓘ Journal of Microbiology, Immunology and Infection ⓘ J MICROBIOL IMMUNOL ⓘ 1684-1182 1995-9133 SCIE IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY ⓘ 2024 3.7 25.2 0 2025-05-07 ⓘ 0 ⓘ ⓘ Acinetobacter; Carbapenem resistance; Conjugation; Metallo-β-lactamase; Plasmid ⓘ ⓘ English Article in press 2025 10.1016/j.jmii.2025.03.008 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Consensus Statements on Tinnitus Assessment and Treatment Outcome Evaluation: A Delphi Study by the Korean Tinnitus Study Group ⓘ Background: Tinnitus is a multifactorial condition with no universally accepted assessment guidelines. The Korean Tinnitus Study Group previously established consensus statements on the definition, classification, and diagnostic tests for tinnitus. As a continuation of this effort, this study aims to establish expert consensus on tinnitus assessment and treatment outcome evaluation, specifically tailored to the Korean clinical context. Methods: A modified Delphi method involving 26 otology experts from across Korea was used. A two-round Delphi survey was conducted to evaluate statements related to tinnitus assessment before and after treatment. Statements were rated on a scale of 1 to 9 for the level of agreement. Consensus was defined as >= 70% agreement (score of 7-9) and <= 15% disagreement (score of 1-3). Statistical measures such as content validity ratio and Kendall's coefficient of concordance (W) were calculated to assess agreement levels. Results: Of the 46 assessment-related statements, 17 (37%) reached consensus, though overall pre-treatment assessments showed weak agreement (Kendall's W = 0.319). Key areas of agreement included the use of the visual analogue scale, numeric rating scale, and validated questionnaires for pre-treatment evaluation. Five statements, such as the use of computed tomography, magnetic resonance imaging, and angiography for diagnosing pulsatile tinnitus, achieved over 90% agreement. For treatment outcome measurements, 8 of 12 statements (67%) reached a consensus, with moderate agreement (Kendall's W = 0.513). Validated questionnaires and psychoacoustic tests were recommended for evaluating treatment effects within 12 weeks. While standardized imaging for pulsatile tinnitus and additional clinical tests were strongly recommended, full consensus was not achieved across all imaging modalities. Conclusion: This study provides actionable recommendations for tinnitus assessment and treatment evaluation, emphasizing the use of standardized tools and individualized approaches based on patient needs. These findings offer a practical framework to enhance consistency and effectiveness in tinnitus management within Korean clinical settings. ⓘ Choo, Oak-Sung; Park, Jung Mee; Park, Euyhyun; Chang, Jiwon; Lee, Min Young; Lee, Ho Yun; Moon, In Seok; Song, Jae-Jun; Lee, Kyu-Yup; Song, Jae-Jin; Nam, Eui-Cheol; Park, Shi Nae; Shim, Hyun Joon; Rah, Yoon Chan; Seo, Jae-Hyun ⓘ Hallym Univ, Kangnam Sacred Heart Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Univ Ulsan, Gangneung Asan Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Kangnung, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Cheonan, South Korea; Ewha Womans Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Dept Otorhinolaryngol, Seoul, South Korea; Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Guro Hosp, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Seongnam, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Coll Med, Dept Otolaryngol, Chunchon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Otolaryngol Head & Neck Surg, 222 Banpo Daero, Seoul 06591, South Korea; Eulji Univ, Sch Med, Nowon Eulji Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Ansan Hosp, 123 Jeokgeum Ro, Ansan 15355, South Korea ⓘ Lee, Min Young/AAM-8435-2020; Song, Jae-Jin/E-4633-2017; Lee, Min/AAM-8435-2020 ⓘ 55579114100; 57194098234; 55943329100; 25625956300; 56691922700; 57189579843; 58027802400; 55574123314; 22135779500; 56294178300; 7005824282; 7501826944; 35171593100; 36978238900; 48161796300 ⓘ rah_yoonchan@korea.ac.kr; revivalseo@catholic.ac.kr; ⓘ JOURNAL OF KOREAN MEDICAL SCIENCE ⓘ J KOREAN MED SCI ⓘ 1011-8934 1598-6357 40 7 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.3 25.2 0 2025-05-07 ⓘ 0 0 Tinnitus; Delphi Study; Consensus; Tinnitus Assessment; Treatment Outcome ⓘ HEARING-LOSS; PREVALENCE; ANXIETY; PITCH; SENSITIVITY; MECHANISMS; AUDIOGRAMS; SEVERITY; FISTULA; NOISE ⓘ Consensus; Delphi Study; Tinnitus; Tinnitus Assessment; Treatment Outcome ⓘ Consensus; Delphi Technique; Female; Humans; Magnetic Resonance Imaging; Male; Republic of Korea; Surveys and Questionnaires; Tinnitus; Tomography, X-Ray Computed; Treatment Outcome; consensus; Delphi study; diagnosis; female; human; male; nuclear magnetic resonance imaging; questionnaire; South Korea; therapy; tinnitus; treatment outcome; x-ray computed tomography ⓘ English 2025 2025-02-24 10.3346/jkms.2025.40.e93 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Consensus Statements on Tinnitus Treatment: A Delphi Study by the Korean Tinnitus Study Group ⓘ Background: Tinnitus is a bothersome condition associated with various mechanisms of action. Although treatment methods vary according to these mechanisms, standardized guidelines would benefit both patients and clinicians. We conducted a Delphi study, a method that collects expert opinions through multiple rounds of questionnaires, to reach a consensus on tinnitus treatment with professional experts. Methods: A two-round modified Delphi survey was conducted to develop a clinical consensus on tinnitus treatment. The experts scored each statement on a scale of 1(highest disagreement) to 9 (highest agreement) for their level of agreement on tinnitus treatment. Consensus was defined when 75% or more of the participants scored 7-9, and 15% or less scored 1-3. To ensure reliability of the responses, the content validity ratio and Kendall's coefficient of concordance were evaluated. Results: Approximately 19 of31 statements reached a consensus. All 3 statements reached a consensus regarding the candidates for treatment. Regarding treatment, 3 of 8 statements on medication, 2 of 2 statements on tinnitus retraining therapy/cognitive behavioral therapy, and 5 of 7 statements on auditory rehabilitation reached a positive consensus. Although all 6 statements regarding miscellaneous treatment reached a consensus, most were negatively agreed. For treatment with neuromodulation, none of the 5 statements reached a consensus. Conclusion: The experts reached a high level of consensus on treatment candidates, tinnitus retraining therapy/cognitive behavioral therapy, and auditory rehabilitation in this modified Delphi study. The results of this study can provide beneficial and practical information for clinicians regarding the treatment of tinnitus. ⓘ Jeong, Junhui; Lee, Ho Yun; Choo, Oak-Sung; Kim, Hantai; Lee, Kyu-Yup; Song, Jae-Jin; Seo, Jae-Hyun; Rah, Yoon Chan; Song, Jae-Jun; Nam, Eui-Cheol; Park, Shi Nae; Moon, In Seok; Shim, Hyun Joon ⓘ Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea; Hallym Univ, Coll Med, Kangnam Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Konyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Daejeon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Seongnam, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Ansan Hosp, Ansan, South Korea; Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Guro Hosp, Seoul, South Korea; Kangwon Natl Univ, Sch Med, Dept Otorhinolaryngol, Chunchon, South Korea; Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 50-1 Yonsei Ro, Seoul 03722, South Korea; Eulji Univ, Sch Med, Nowon Eulji Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, 68 Hangeulbiseok Ro, Seoul 01830, South Korea ⓘ ; Song, Jae-Jin/E-4633-2017 ⓘ 57225936910; 57189579843; 55579114100; 57221994950; 59903264800; 56294178300; 48161796300; 36978238900; 55574123314; 7005824282; 7501826944; 59903237500; 59900721000 ⓘ ismoonmd@yuhs.ac; eardoc11@naver.com; ⓘ JOURNAL OF KOREAN MEDICAL SCIENCE ⓘ J KOREAN MED SCI ⓘ 1011-8934 1598-6357 40 18 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.3 25.2 0 2025-06-11 ⓘ 0 0 Tinnitus; Treatment; Delphi Study ⓘ IMPLANT; STIMULATION; THERAPY ⓘ Delphi Study; Tinnitus; Treatment ⓘ Cognitive Behavioral Therapy; Consensus; Delphi Technique; Female; Humans; Male; Republic of Korea; Surveys and Questionnaires; Tinnitus; cognitive behavioral therapy; consensus; Delphi study; female; human; male; pathology; questionnaire; South Korea; therapy; tinnitus ⓘ English 2025 2025-05-12 10.3346/jkms.2025.40.e75 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Correction ⓘ Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020) (vol 57, pg 437, 2024) ⓘ ⓘ Lee, Jaehee; Seo, Hyewon; Kim, Dohyang; Hwang, Jinseub; Kwon, Jin-Won ⓘ Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ⓘ 13805476000; 55612130200; 57218821860; 57189231296; 16202951700 ⓘ jwkwon@knu.ac.kr; ⓘ JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION ⓘ J MICROBIOL IMMUNOL ⓘ 1684-1182 1995-9133 58 1 SCIE IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY ⓘ 2024 3.7 25.2 0 2025-05-07 ⓘ 0 0 ⓘ ⓘ ⓘ adult; cohort analysis; controlled study; erratum; female; human; major clinical study; male; diagnosis ⓘ English 2025 2025-02 10.1016/j.jmii.2024.12.001 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Physician-Scientist Training System and Development Strategies in Korea ⓘ Physician-scientists play a pivotal role in bridging clinical practice and biomedical research, advancing medical science, and tackling complex healthcare challenges. In South Korea, the declining number of medical doctors engaging in basic medical sciences has prompted the implementation ofvarious training initiatives since the 2000s. Notable initiatives, such as the Integrated Physician-Scientist Training Program (2019) and the Global Physician-Scientist Training Program (2024), aim to cultivate multidisciplinary physician-scientists capable of addressing unmet medical needs. This study offers a comprehensive overview of the current training systems, funding mechanisms, and strategic approaches for physician-scientists in South Korea, compares them with international best practices, and proposes actionable policy recommendations to enhance their effectiveness and long-term sustainability. ⓘ Eom, Gwang Hyeon; Kim, Jungmin; Kim, Jong-Il; Choi, Hyo Yi; Lee, Dong Hyeon ⓘ Chonnam Natl Univ, Med Sch, Dept Pharmacol, Hwasun, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Seoul Natl Univ, Coll Med, Genom Med Inst, Seoul, South Korea; Korea Assoc Med Coll, Training Ctr Innovat Med Scientist, Seoul, South Korea; CHA Univ, Sch Med, Dept Physiol, 120 Haeryong Ro, Pochon 11160, South Korea; CHA Inst Future Med, Med Ctr, Res Inst, Seongnam, South Korea ⓘ Lee, Dong Hyeon/MXK-3630-2025 ⓘ 13405024200; 57211297681; 56016185900; 59748003200; 57049848800 ⓘ leedh@cha.ac.kr; ⓘ JOURNAL OF KOREAN MEDICAL SCIENCE ⓘ J KOREAN MED SCI ⓘ 1011-8934 1598-6357 40 15 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.3 25.2 4.17 2025-05-07 ⓘ 0 1 Physician-Scientist; Training System; Development Strategy; Korea ⓘ RECOMMENDATIONS; WORKFORCE ⓘ Development Strategy; Korea; Physician–Scientist; Training System ⓘ Biomedical Research; Education, Medical; Humans; Physicians; Republic of Korea; education; human; medical education; medical research; physician; South Korea ⓘ English 2025 2025-04-21 10.3346/jkms.2025.40.e140 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Questioning the Addition of Fluoroquinolone on Mortality in Severe Community-Acquired Pneumonia: A multicenter study in Korea ⓘ Background: The use of fluoroquinolone (FQ) combination therapy as empirical treatment for severe community-acquired pneumonia (sCAP) remains unclear. In this study, we aimed to evaluate its clinical impact. Methods: This retrospective study was conducted in seven large university-affiliated hospitals in Korea. It included adult inpatients (age ≥19 years) diagnosed with sCAP between March 2020 and February 2023, identified through third-ranked pneumonia codes, who received anti-pseudomonal beta-lactam (APBL) and/or FQ within 24 h of admission. Propensity-score matching compared monotherapy and combination therapy outcomes. Results: Of 588 enrolled patients with sCAP, 177 per group were analyzed post-matching. No significant differences were found in all-cause in-hospital mortality (36.7 % vs. 36.2 %, P = 0.917), in-hospital mortality from pneumonia aggravation (29.9 % vs. 30.5 %, P = 1.000), or 30-day mortality (26.6 % vs. 29.4 %, P = 0.251). FQ combination therapy did not affect 30-day mortality significantly (P = 0.489). None of the variables significantly influenced 30-day mortality, pneumonia recurrence within 28 days, total antibiotic duration, or hospital stay. Conclusions: In patients with sCAP, outcomes did not differ significantly between APBL monotherapy and FQ combination therapy. This suggests that even in severe CAP, an individualized treatment strategy based on the causative agent may be more appropriate than indiscriminate combination therapy. © 2025 ⓘ Lee, Se Ju; Hwang, Soyoon; Yun, Ji Hyun; Chan Kim, Yong; Choi, Min Joo; Lee, Jin-Soo; Kwon, Ki Tae; Choi, Won Suk; Na, Yeseul; Kim, So Hee; Kim, Taehyen; Seok, Hyeri; Kim, Bongyoung ⓘ Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, South Korea; Division of Infectious Disease, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea; Division of Infectious Disease, Department of Internal Medicine, International St. Mary's hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, South Korea; Division of Nursing, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea; Division of Infectious Disease, Department of Internal Medicine, International St. Mary's hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, South Korea, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea ⓘ ⓘ 57192094225; 59510718100; 57226560987; 57817997500; 59774008500; 59866251900; 59660097500; 56718971800; 59534694600; 59863799400; 59866252000; 56803460700; 55622077200 ⓘ hyeri.seok@gmail.com; sobakas@hanyang.ac.kr; ⓘ Journal of Microbiology, Immunology and Infection ⓘ J MICROBIOL IMMUNOL ⓘ 1684-1182 1995-9133 SCIE IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY ⓘ 2024 3.7 25.2 0 2025-06-11 ⓘ 0 ⓘ ⓘ Anti-bacterial agent; Community-acquired pneumonia; Fluoroquinolone; Mortality ⓘ ⓘ English Article in press 2025 10.1016/j.jmii.2025.04.004 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Risk Factors of FEV1/FVC Decline in COPD Patients ⓘ Background: Factors influencing the decline in forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) for chronic obstructive pulmonary disease (COPD) progression remain uncertain. We aimed to identify risk factors associated with rapid FEV1/ FVC decline in patients with COPD. Methods: This multi-center observational study was conducted from January 2012 to December 2022. Eligible patients were monitored with symptoms, spirometric tests, and treatment patterns over 3 years. Rapid FEV1/FVC decliners were defined as the quartile of patients exhibiting the highest annualized percentage decline in FEV1/FVC. Results: Among 1,725 patients, 435 exhibited rapid FEV1/FVC decline, with an annual change of -2.5%p (interquartile range, -3.5 to -2.0). Rapid FEV1/FVC decliners exhibited lower body mass index (BMI), higher smoking rates, elevated post-bronchodilator (BD) FEV1, higher post-BD FEV1/ FVC, and a lower prevalence of Staging of Airflow Obstruction by Ratio (STAR) stage IV. Rapid FEV1/FVC decline was not linked to the annual exacerbation rate, but there was an association with symptom deterioration and FEV1 decline. In multivariable analyses, low BMI, current smoking, increased modified Medical Research Council dyspnoea score, low post-BD FEV1, low STAR stage, high forced mid-expiratory flow (FEF25-75%), accelerated FEV1 decline, and not initiating dual BD therapy were identified as independent risk factors for rapid FEV1/FVC decline. Conclusion: We identified the risk factors for rapid FEV1/FVC decline, including BMI, smoking, symptoms deterioration, FEV1 decline, and adherence to standard inhaler treatment. Our findings underscore the potential benefits of maintaining consistent use of long-acting beta-agonist/long-acting muscarinic antagonist even in the presence of worsening symptoms, in attenuating FEV1/FVC decline. ⓘ Kim, Na Young; Kim, Deog Kyeom; Park, Shinhee; Hwang, Yong Il; Seo, Hyewon; Park, Dongil; Park, Seoung Ju; Lee, Jin Hwa; Yoo, Kwang Ha; Lee, Hyun Woo ⓘ Hallym Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med,Coll Med,Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Allergy & Resp Med, Bucheon Hosp, Bucheon, South Korea; Hallym Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sacred Heart Hosp, Anyang, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Pulmonol & Crit Care Med, Daejeon, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Med Sch, Jeonju, South Korea; Ewha Womans Univ, Dept Internal Med, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea; Konkuk Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sch Med, Seoul, South Korea ⓘ Park, Dongil/AAB-7275-2021; HWANG, YONG/AAU-7121-2021; Park, Seoungju/D-4444-2014; Lee, Hyun Woo/AAH-8473-2020 ⓘ 58914386900; 57219957699; 57211965319; 34570249800; 55612130200; 59656900300; 8578599900; 56646645800; 57693301700; 57205720858 ⓘ athrunzara86@snu.ac.kr; athrunzara86@gmail.com; ⓘ JOURNAL OF KOREAN MEDICAL SCIENCE ⓘ J KOREAN MED SCI ⓘ 1011-8934 1598-6357 40 6 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.3 25.2 0 2025-05-07 ⓘ 0 1 Chronic Obstructive Pulmonary Disease; Cohort Studies; Forced Expiratory Volume; Forced Vital Capacity; Respiratory Function Tests; Risk Factors ⓘ OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION DECLINE; SEVERITY; OUTCOMES ⓘ Chronic Obstructive Pulmonary Disease; Cohort Studies; Forced Expiratory Volume; Forced Vital Capacity; Respiratory Function Tests; Risk Factors ⓘ Aged; Body Mass Index; Bronchodilator Agents; Disease Progression; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Risk Factors; Smoking; Spirometry; Vital Capacity; bronchodilating agent; aged; body mass; chronic obstructive lung disease; clinical trial; disease exacerbation; drug therapy; female; forced expiratory volume; human; male; middle aged; multicenter study; pathophysiology; risk factor; smoking; spirometry; vital capacity ⓘ English 2025 2025-02-17 10.3346/jkms.2025.40.e32 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Tuberculous and Malignant Pleural Effusions With Adenosine Deaminase Levels of 40-70 IU/L: Trends in New Cases Over Time and Differentiation Between Groups ⓘ Background: The diagnosis of tuberculous pleural effusion (TPE) often relies on pleural fluid adenosine deaminase (ADA) levels. The diagnostic utility of ADA, however, is influenced by the prevalence of tuberculosis (TB) in local populations. Malignant pleural effusion (MPE) cases can exhibit moderately elevated ADA levels comparable to those seen in TPE. As population aging potentially impacts ADA levels, global TB incidence is decreasing whereas the burden of malignancy is on the rise. Consequently, epidemiological shifts and temporal changes in ADA distribution complicate the differential diagnosis between TPE and MPE when ADA levels are within the 40-70 IU/L range. Nonetheless, data specific to this subset are scarce. Methods: This retrospective study included consecutive patients aged > 18 years with confirmed TPE and MPE, spanning from 2012 to 2023. ADA levels in pleural fluid were categorized into three groups: 70 IU/L. The study examined annual trends in the frequency of new cases and ADA level distributions over time and identified discriminating factors between TPE and MPE in cases with ADA levels of 40-70 IU/L. Results: In total, 297 TPE and 369 MPE cases were included in this study. Over the study period, the frequency of TPE progressively declined, while that of MPE increased. In the most recent four-year period, new TPE and MPE cases with ADA levels of 40-70 IU/L occurred at comparable numbers. Multivariable analysis identified pleural fluid carcinoembryonic antigen (CEA) levels and the number of focal pleural nodules as independent predictors for MPE. Specifically, the presence of either CEA levels > 15.7 ng/mL or more than eight pleural nodules yielded the highest diagnostic accuracy with a sensitivity of 88%, specificity of 100%, and an area under the curve of 0.95. Conclusion: The differential diagnosis between TPE and MPE with pleural ADA levels of 40-70 IU/L has become increasingly critical due to evolving epidemiological patterns and ADA distribution changes over time. Pleural fluid CEA levels and the characteristics of pleural nodules may offer valuable guidance in distinguishing between TPE and MPE within this diagnostic gray zone. ⓘ Lee, Jaehee; Park, Jongmin; Lim, Jae Kwang; Park, Ji Eun; Lee, Yong Hoon; Choi, Sun Ha; Seo, Hyewon; Yoo, Seung Soo; Lee, Shin Yup; Cha, Seung-Ick; Park, Jae Yong; Kim, Chang Ho ⓘ Kyungpook Natl Univ, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea ⓘ ⓘ 13805476000; 57216463879; 59699083900; 57195437358; 57199022948; 57199723585; 55612130200; 56479781600; 49863712700; 35227126400; 58360293800; 7409873555 ⓘ kimch@knu.ac.kr; ⓘ JOURNAL OF KOREAN MEDICAL SCIENCE ⓘ J KOREAN MED SCI ⓘ 1011-8934 1598-6357 40 13 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.3 25.2 0 2025-05-07 ⓘ 0 1 Trend Over Time; Tuberculous Pleural Effusion; Malignant Pleural Effusion; Adenosine Deaminase; Gray Zone ⓘ CARCINOEMBRYONIC ANTIGEN; DIAGNOSIS; FLUID ⓘ Adenosine Deaminase; Gray Zone; Malignant Pleural Effusion; Trend Over Time; Tuberculous Pleural Effusion ⓘ Adenosine Deaminase; Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Humans; Male; Middle Aged; adenosine deaminase; adult; aged; differential diagnosis; female; human; male; metabolism; middle aged; very elderly ⓘ English 2025 2025-04-07 10.3346/jkms.2025.40.e35 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ 3D-Printable, Durable, and Wearable Poly(vinyl alcohol)/Nanosilicate/Borax Organohydrogel Fibers for Digital Healthcare Devices ⓘ The growing aging population underscores the urgent need for digital healthcare devices that can continuously monitor health and provide early disease diagnosis, rehabilitation, and timely medical intervention. Herein, robust organohydrogel fibers (OHFs) fabricated through continuous wet spinning using an instantaneous gelation system of poly(vinyl alcohol) (PVA) and borax are described. The incorporation of laponite (LP) imparts shear-thinning behavior to the polymer solution and significantly enhances the durability of the hydrogel by simply mixing it with PVA. The resulting organohydrogel fibers exhibit impressive tensile strength (similar to 300 kPa) and high strain capacity (up to 600%), thereby making them ideal for soft robotics applications. The use of glycerol and sodium chloride (NaCl) in a coagulation bath endows the hydrogel with antifreezing properties (effective at -30 degrees C), long-term storage stability (7 days), and high conductivity (4.2 Sm-1). With a linear gauge factor of 1.24 for strains up to 800%, these fibers demonstrate exceptional reliability as wearable strain sensors that can accurately detect human movement. The integration of 3D printing technology opens up a broad range of advanced healthcare device applications and offers significant potential for future developments in digital health. ⓘ Kim, Tae In; Park, Yeon Woo; Park, Minha; Kim, Min Hee; Park, Won Ho ⓘ Chungnam Natl Univ, Dept Organ Mat Engn, Daejeon 34134, South Korea; Kyungpook Natl Univ, Dept Text Engn, Sangju 37224, South Korea ⓘ ⓘ 58729381300; 59936293900; 59936424800; 57188948163; 59936029000 ⓘ mhkim88@knu.ac.kr; parkwh@cnu.ac.kr; ⓘ ACS APPLIED ELECTRONIC MATERIALS ⓘ ACS APPL ELECTRON MA ⓘ 2637-6113 7 12 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 4.7 25.3 N/A ⓘ 0 0 Nanocomposites; Organohydrogelfibers; 3D Printing; Wearable strain sensors; Health monitoring ⓘ ZWITTERIONIC HYDROGEL; ADHESIVE; MOTION; SKIN ⓘ 3D Printing; Health monitoring; Nanocomposites; Organohydrogel fibers; Wearable strain sensors ⓘ Biomedical engineering; Diagnosis; Electronic health record; Nutrition; Patient treatment; 3-D printing; 3D-printing; Aging population; Early disease; Health monitoring; Organohydrogel fiber; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol); Poly(vinyl alcohol) (PVA); Strain sensors; Diseases ⓘ English 2025 2025-06-06 10.1021/acsaelm.5c00573 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Modeling of Conductive Filament Behaviors According to Inorganic Concentration Changes in Hybrid Polymeric Ultra-Thin Films ⓘ Resistive random-access memory (ReRAM) has attracted considerable attention as a promising memory technology for the internet of things, artificial intelligence, and neuromorphic computing, driving the advancements in the Fourth Industrial Revolution. Among various approaches, ultrathin hybrid films fabricated via an initiated chemical vapor deposition (iCVD) process (iCVD) have emerged as viable candidates for ReRAM devices, offering tunable performance through precise control of the organic-inorganic ratios. However, electrical and chemical properties of hybrid-film-based ReRAM devices have not yet been systemically investigated, making it difficult to establish a comprehensive understanding of conductive filaments (CF) behavior that governs device performance. In this study, we systematically investigate the effects of Al, Hf, and Zr composition variations on the resistive switching behavior of ultrathin hybrid-film based ReRAM (H-ReRAM). Our results demonstrate that the inorganic content of H-ReRAMs gradually reduces the low-resistance state in all H-ReRAM. Conversely, while the high-resistance state (HRS) of Al H-ReRAMs decreases significantly, the HRS of Hf- and Zr-based H-ReRAMs increases, resulting in an improved on/off ratio. Furthermore, we propose a physics-based numerical model that elucidates CF dynamics as a function of the inorganic composition within the hybrid films. This model provides key insights into the material characteristics and switching mechanisms, offering a fundamental understanding that is crucial for optimizing H-ReRAM performance. Our findings contribute to the development of high-performance memory and neuromorphic devices, supporting the next generation of advanced computing systems. ⓘ Kim, Ji In; Kim, Yeong Kwon; Jang, Byung Chul; Kim, Min Ju ⓘ Dankook Univ, Dept Foundry Engn, Yongin 16890, Gyeonggi Do, South Korea; Dankook Univ, Dept Semicond Convergence Engn, Yongin 16890, Gyeonggi Do, South Korea; Dankook Univ, Dept Elect & Elect Engn, Yongin 16890, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea ⓘ Kim, Min/AAZ-9598-2021; Jang, Byung Chul/GYV-0656-2022 ⓘ 59935629500; 58120005900; 9238827900; 55686359500 ⓘ bc.jang@knu.ac.kr; minju9062@dankook.ac.kr; ⓘ ACS APPLIED ELECTRONIC MATERIALS ⓘ ACS APPL ELECTRON MA ⓘ 2637-6113 7 12 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 4.7 25.3 N/A ⓘ 0 0 hybrid film; ultrathin; ReRAM; CFmodeling; iCVD ⓘ CHEMICAL-VAPOR-DEPOSITION; RERAM; MECHANISMS ⓘ CF modeling; hybrid film; iCVD; ReRAM; ultrathin ⓘ Electronegativity; NP-hard; Plasma CVD; Turing machines; Conductive filament modeling; Conductive filaments; High-resistance state; Hybrid film; Initiated chemical vapor depositions; Inorganic concentration; Performance; Random access memory; Resistive random-access memory; Ultra-thin; Ultrathin films ⓘ English 2025 2025-06-06 10.1021/acsaelm.5c00420 ⓘ 바로가기 바로가기 바로가기 바로가기
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