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| ○ | ○ | Article | Projected background and sensitivity of AMoRE-II | AMoRE-II aims to search for neutrinoless double beta decay (0 nu beta beta) with an array of 423 Li-2(100) MoO4 crystals operating in the cryogenic system as the main phase of the Advanced Molybdenum-based Rare process Experiment (AMoRE). AMoREhas been planned to operate in three phases: AMoRE-pilot, AMoRE-I, and AMoRE-II. AMoREII is currently being installed at the Yemi Underground Laboratory, located approximately 1000 m deep in Jeongseon, Korea. The goal of the experiment is to reach an exclusion half-life sensitivity to the 0 nu beta beta of Mo-100 on the level of T-1/2 (0 nu beta beta) > 6 x 10(26) year that covers completely the inverted Majorana neutrino mass hierarchy region of (15-46) meV. To achieve this, the background level of the experimental configurations and possible background sources of gamma and beta events should be well understood. We have intensively performed Monte Carlo simulations using the GEANT4 toolkit in all the experimental configurations with potential sources. We report the estimated background level that meets the 10(-4) counts/(keV center dot kg center dot year) requirement forAMoRE-II in the Region Of Interest (ROI) and show the projected half-life sensitivity based on the simulation study. | Agrawal, A.; Alenkov, V. V.; Aryal, P.; Beyer, J.; Bhandari, B.; Boiko, R. S.; Boonin, K.; Buzanov, O.; Byeon, C. R.; Chanthima, N.; Cheoun, M. K.; Choe, J. S.; Choi, Seonho; Choudhury, S.; Chung, J. S.; Danevich, F. A.; Djamal, M.; Drung, D.; Enss, C.; Fleischmann, A.; Gangapshev, A. M.; Gastaldo, L.; Gavrilyuk, Y. M.; Gezhaev, A. M.; Gileva, O.; Grigorieva, V. D.; Gurentsov, V. I.; Ha, C.; Ha, D. H.; Ha, E. J.; Hwnag, D. H.; Jeon, E. J.; Jeon, J. A.; Jo, H. S.; Kaewkhao, J.; Kang, C. S.; Kang, W. G.; Kazalov, V. V.; Kempf, S.; Khan, A.; Khan, S.; Kim, D. Y.; Kim, G. W.; Kim, H. B.; Kim, Ho-Jong; Kim, H. J.; Kim, H. L.; Kim, H. S.; Kim, M. B.; Kim, S. C.; Kim, S. K.; Kim, S. R.; Kim, W. T.; Kim, Y. D.; Kim, Y. H.; Kirdsiri, K.; Ko, Y. J.; Kobychev, V. V.; Kornoukhov, V.; Kuzminov, V. V.; Kwon, D. H.; Lee, C. H.; Lee, DongYeup; Lee, E. K.; Lee, H. J.; Lee, H. S.; Lee, J.; Lee, J. Y.; Lee, K. B.; Lee, M. H.; Lee, M. K.; Lee, S. W.; Lee, Y. C.; Leonard, D. S.; Lim, H. S.; Mailyan, B.; Makarov, E. P.; Nyanda, P.; Oh, Y.; Olsen, S. L.; Panasenko, S. I.; Park, H. K.; Park, H. S.; Park, K. S.; Park, S. Y.; Polischuk, O. G.; Prihtiadi, H.; Ra, S.; Ratkevich, S. S.; Rooh, G.; Sala, E.; Sari, M. B.; Seo, J.; Seo, K. M.; Sharma, B.; Shin, K. A.; Shlegel, V. N.; Siyeon, K.; So, J.; Sokur, N. V.; Son, J. K.; Song, J. W.; Srisittipokakun, N.; Tretyak, V. I.; Wirawan, R.; Woo, K. R.; Yeon, H. J.; Yoon, Y. S.; Yue, Q. | Indian Inst Sci, Bangalore, Karnataka, India; JSC FOMOS Mat, Moscow, Russia; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Phys Tech Bundesanstalt, Braunschweig, Germany; Univ Sci & Technol UST, Daejeon, South Korea; NASU, Inst Nucl Res, Kiev, Ukraine; Nakhon Pathom Rajabhat Univ, Wang Taku, Thailand; Soongsil Univ, Dept Phys, Seoul, South Korea; Inst Basic Sci IBS, Ctr Underground Phys, Daejeon, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul, South Korea; Chung Ang Univ, Dept Phys, Seoul, South Korea; Inst Teknol, Dept Phys, Bandung, Indonesia; Kirchhoff Inst Phys, Heidelberg, Germany; Neutrino Observ INR RAS, Karachai Cherkesia, Russia; Russian Acad Sci, Siberian Branch, Nikolaev Inst Inorgan Chem, Novosibirsk, Russia; Kohat Univ Sci & Technol, Dept Phys, Kohat, Pakistan; Sejong Univ, Dept Phys & Astron, Seoul, South Korea; Natl Res Nucl Univ MEPhI, Moscow, Russia; Dept Accelerator Sci, Sejong, South Korea; Korea Res Inst Stand & Sci, Daejeon, South Korea; Florida Inst Technol, Melbourne, FL 32901 USA; Kharkov Natl Univ, Kharkiv, Ukraine; Abdul Wali Khan Univ, Dept Phys, Mardan, Pakistan; Univ Mataram, Dept Phys, Mataram, Indonesia; Tsinghua Univ, Beijing, Peoples R China; Karlsruhe Inst Technol KIT, Inst Micro & Nanoelect Syst IMS, Karlsruhe, Germany; Univ Negeri Malang, Dept Phys, Malang, Indonesia; INFN, Sez Roma, Rome, Italy; INFN, Lab Nazl Gran Sasso, Rome, Italy | Lee, Hyun Su/G-3392-2014; Panasenko, Serhii/LSM-4490-2024; Gileva, Olga/JMQ-2748-2023; Kobychev, Vladislav/B-3322-2008; Danevich, Fedor/D-2727-2012; Boiko, Roman/M-8181-2014; Wirawan, Rahadi/H-9045-2016; Olga, Gileva/JMQ-2748-2023; Grigorieva, Veronika/ABG-6479-2020; Boonin, Kitipun/HKF-7350-2023; Kazalov, Vladimir/V-6021-2018; Sari, Mona Berlian/HGV-2710-2022; Kempf, Sebastian/P-7612-2016; Khan, Arshad/ABB-1566-2021 | 58849427900; 8954185600; 57196222852; 16019108300; 58829777600; 22953206600; 35361494500; 6507228789; 59050570500; 35361597600; 6701826023; 57211272681; 57199723894; 57226314694; 58194129700; 6701545407; 6506355194; 7003654818; 56227887300; 8656533600; 6506346988; 6602197897; 6602715345; 18436707000; 57196456549; 56120448600; 6603220327; 17342119700; 57023186700; 12778681800; 59202671200; 57204519171; 24478376500; 35227429400; 23974520300; 58437336600; 24401181300; 15750926300; 55418354700; 56017063700; 56266707900; 57218106366; 57209050651; 55195026700; 59616483600; 58483690400; 57218825747; 57709039100; 58193570900; 7601594620; 59102407800; 56401942100; 57211502868; 7410207253; 57196171764; 34881618200; 56030036300; 36094219000; 7003873891; 6603413895; 57201795741; 59880372600; 58848262200; 57226673940; 57225012168; 56113238600; 57226402706; 57204797944; 59612763600; 57198252980; 7409120947; 59631050700; 57203244766; 7201953933; 57907833600; 24528726500; 16307413300; 57423423000; 57188969853; 57209049904; 6701703012; 8455192000; 57216599536; 35225979300; 57190583343; 34168294300; 57188983477; 16480794500; 6603634096; 24401665700; 14623225700; 57210602872; 58848723700; 56647489700; 57209181591; 57203522213; 6602324736; 6507719993; 35277558300; 57200598341; 57022959600; 58848262600; 35365411300; 35290939700; 55871401900; 57211276680; 58078013400; 35243798200; 59454528800 | ejjeon@ibs.re.kr; jeewon.seo.ibs@gmail.com; | EUROPEAN PHYSICAL JOURNAL C | EUR PHYS J C | 1434-6044 | 1434-6052 | 85 | 1 | SCIE | PHYSICS, PARTICLES & FIELDS | 2024 | 4.8 | 24.2 | 4.26 | 2025-05-07 | 1 | 1 | DOUBLE-BETA DECAY; NEUTRINOS | Background level; Cryogenic system; Half lives; Majorana neutrino mass; Mass hierarchy; Monte Carlo's simulation; Neutrinoless double-beta decays; Three phase; Three phasis; Underground laboratory | English | 2025 | 2025-01-08 | 10.1140/epjc/s10052-024-13516-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Search for pair production of heavy particles decaying to a top quark and a gluon in the lepton plus jets final state in proton-proton collisions at √s=13 TeV | A search is presented for the pair production of new heavy resonances, each decaying into a top quark (t) or antiquark and a gluon (g). The analysis uses data recorded with the CMS detector from proton-proton collisions at a center-of-mass energy of 13 TeV at the LHC, corresponding to an integrated luminosity of 138 fb(-1). Events with one muon or electron, multiple jets, and missing transverse momentum are selected. After using a deep neural network to enrich the data sample with signal-like events, distributions in the scalar sum of the transverse momenta of all reconstructed objects are analyzed in the search for a signal. No significant deviations from the standardmodel prediction are found. Upper limits at 95% confidence level are set on the product of cross section and branching fraction squared for the pair production of excited top quarks in the t* -> tg decay channel. The upper limits range from 120 to 0.8 fb for a t* with spin-1/2 and from 15 to 1.0 fb for a t* with spin-3/2. These correspond to mass exclusion limits up to 1050 and 1700 GeV for spin-1/2 and spin-3/2 t* particles, respectively. These are the most stringent limits to date on the existence of t* -> tg resonances. | Hayrapetyan, A.; Tumasyan, A.; Adam, W.; Andrejkovic, J. W.; Benato, L.; Bergauer, T.; Chatterjee, S.; Damanakis, K.; Dragicevic, M.; Hussain, P. S.; Jeitler, M.; Krammer, N.; Li, A.; Liko, D.; Mikulec, I.; Schieck, J.; Schoefbeck, R.; Schwarz, D.; Sonawane, M.; Waltenberger, W.; Wulz, C. -E.; Janssen, T.; Van Laer, T.; Van Mechelen, P.; Breugelmans, N.; D'Hondt, J.; Dansana, S.; De Moor, A.; Delcourt, M.; Heyen, F.; Lowette, S.; Makarenko, I.; Muller, D.; Tavernier, S.; Tytgat, M.; Van Onsem, G. P.; Van Putte, S.; Vannerom, D.; Bilin, B.; Clerbaux, B.; Das, A. K.; De Bruyn, I.; De Lentdecker, G.; Evard, H.; Favart, L.; Gianneios, P.; Jaramillo, J.; Khalilzadeh, A.; Khan, F. A.; Lee, K.; Malara, A.; Paredes, S.; Shahzad, M. A.; Thomas, L.; Vanden Bemden, M.; Vander Velde, C.; Vanlaer, P.; De Coen, M.; Dobur, D.; Gokbulut, G.; Hong, Y.; Knolle, J.; Lambrecht, L.; Marckx, D.; Amarilo, K. Mota; Skovpen, K.; Van Den Bossche, N.; van der Linden, J.; Wezenbeek, L.; Benecke, A.; Bethani, A.; Bruno, G.; Caputo, C.; De Jeneret, J. De Favereau; Delaere, C.; Donertas, I. S.; Giammanco, A.; Guzel, A. O.; Jain, Sa.; Lemaitre, V.; Lidrych, J.; Mastrapasqua, P.; Tran, T. T.; Turkcapar, S.; Alves, G. A.; Coelho, E.; Correia Silva, G.; Hensel, C.; Menezes De Oliveira, T.; Mora Herrera, C.; Rebello Teles, P.; Soeiro, M.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Alda Junior, W. L.; Barroso Ferreira Filho, M.; Brandao Malbouisson, H.; Carvalho, W.; Chinellato, J.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; Fonseca De Souza, S.; Gomes De Souza, R.; Laux Kuhn, T.; Macedo, M.; Martins, J.; Mundim, L.; Nogima, H.; Pinheiro, J. P.; Santoro, A.; Sznajder, A.; Thiel, M.; Bernardes, C. A.; Calligaris, L.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Maietto Silverio, I.; Mercadante, P. G.; Novaes, S. F.; Orzari, B.; Padula, Sandra S.; Aleksandrov, A.; Antchev, G.; Hadjiiska, R.; Iaydjiev, P.; Misheva, M.; Shopova, M.; Sultanov, G.; Dimitrov, A.; Litov, L.; Pavlov, B.; Petkov, P.; Petrov, A.; Shumka, E.; Keshri, S.; Laroze, D.; Thakur, S.; Cheng, T.; Javaid, T.; Yuan, L.; Hu, Z.; Liang, Z.; Liu, J.; Chen, G. M.; Chen, H. S.; Chen, M.; Iemmi, F.; Jiang, C. H.; Kapoor, A.; Liao, H.; Liu, Z. -A.; Sharma, R.; Song, J. N.; Tao, J.; Wang, C.; Wang, J.; Wang, Z.; Zhang, H.; Zhao, J.; Agapitos, A.; Ban, Y.; Deng, S.; Guo, B.; Jiang, C.; Levin, A.; Li, C.; Li, Q.; Mao, Y.; Qian, S.; Qian, S. J.; Qin, X.; Sun, X.; Wang, D.; Yang, H.; Zhang, L.; Zhao, Y.; Zhou, C.; Yang, S.; You, Z.; Jaffel, K.; Lu, N.; Bauer, G.; Li, B.; Yi, K.; Zhang, J.; Li, Y.; Lin, Z.; Lu, C.; Xiao, M.; Avila, C.; Barbosa Trujillo, D. A.; Cabrera, A.; Florez, C.; Fraga, J.; Reyes Vega, J. A.; Ramirez, F.; Rendon, C.; Rodriguez, M.; Ruales Barbosa, A. A.; Ruiz Alvarez, J. D.; Giljanovic, D.; Godinovic, N.; Lelas, D.; Sculac, A.; Kovac, M.; Petkovic, A.; Sculac, T.; Bargassa, P.; Brigljevic, V.; Chitroda, B. K.; Ferencek, D.; Jakovcic, K.; Starodumov, A.; Susa, T.; Attikis, A.; Christoforou, K.; Hadjiagapiou, A.; Leonidou, C.; Mousa, J.; Nicolaou, C.; Paizanos, L.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Saka, H.; Stepennov, A.; Finger, M.; Finger, M., Jr.; Kveton, A.; Ayala, E.; Carrera Jarrin, E.; Abdalla, H.; Assran, Y.; El-mahdy, B.; Al-Mashad, M. Abdullah; Mahmoud, M. A.; Ehataht, K.; Kadastik, M.; Lange, T.; Nandan, S.; Nielsen, C.; Pata, J.; Raidal, M.; Tani, L.; Veelken, C.; Kirschenmann, H.; Osterberg, K.; Voutilainen, M.; Bharthuar, S.; Bin Norjoharuddeen, N.; Brucken, E.; Garcia, F.; Inkaew, P.; Kallonen, K. T. S.; Lampen, T.; Lassila-Perini, K.; Lehti, S.; Linden, T.; Myllymaki, M.; Rantanen, M. M.; Siikonen, H.; Tuominiemi, J.; Luukka, P.; Petrow, H.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Faure, J. L.; Ferri, F.; Ganjour, S.; Gras, P.; de Monchenault, G. Hamel; Kumar, M.; Lohezic, V.; Malcles, J.; Orlandi, F.; Portales, L.; Rosowsky, A.; Sahin, M. O.; Savoy-Navarro, A.; Simkina, P.; Titov, M.; Tornago, M.; Beaudette, F.; Boldrini, G.; Busson, P.; Cappati, A.; Charlot, C.; Chiusi, M.; Cuisset, T. D.; Damas, F.; Davignon, O.; De Wit, A.; Ehle, I. T.; Alves, B. A. Fontana Santos; Ghosh, S.; Gilbert, A.; de Cassagnac, R. Granier; Hakimi, A.; Harikrishnan, B.; Kalipoliti, L.; Liu, G.; Nguyen, M.; Ochando, C.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Gomez, L. Urda; Vernazza, E.; Zabi, A.; Zghiche, A.; Agram, J. -L.; Andrea, J.; Apparu, D.; Bloch, D.; Brom, J. -M.; Chabert, E. C.; Collard, C.; Falke, S.; Goerlach, U.; Haeberle, R.; Le Bihan, A. -C.; Meena, M.; Poncet, O.; Saha, G.; Sessini, M. 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Torres Da Silva; Wiedenbeck, S.; Zaleski, S.; Dziwok, C.; Fluegge, G.; Kress, T.; Nowack, A.; Pooth, O.; Stahl, A.; Ziemons, T.; Zotz, A.; Petersen, H. Aarup; Martin, M. Aldaya; Alimena, J.; Amoroso, S.; An, Y.; Bach, J.; Baxter, S.; Bayatmakou, M.; Gonzalez, H. Becerril; Behnke, O.; Belvedere, A.; Blekman, F.; Borras, K.; Campbell, A.; Cardini, A.; Cheng, C.; Colombina, F.; Eckerlin, G.; Eckstein, D.; Banos, L. I. Estevez; Gallo, E.; Geiser, A.; Guglielmi, V.; Guthoff, M.; Hinzmann, A.; Jeppe, L.; Kaech, B.; Kasemann, M.; Kleinwort, C.; Kogler, R.; Komm, M.; Kruecker, D.; Lange, W.; Pernia, D. Leyva; Lipka, K.; Lohmann, W.; Lorkowski, F.; Mankel, R.; Melzer-Pellmann, I. -A.; Morentin, M. Mendizabal; Meyer, A. B.; Milella, G.; Figueroa, K. Moral; Mussgiller, A.; Nair, L. 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F.; Wassmer, M.; Wieland, S.; Wittig, F.; Wolf, R.; Zuo, X.; Anagnostou, G.; Daskalakis, G.; Kyriakis, A.; Papadopoulos, A.; Stakia, A.; Kontaxakis, P.; Melachroinos, G.; Painesis, Z.; Papavergou, I.; Paraskevas, I.; Saoulidou, N.; Theofilatos, K.; Tziaferi, E.; Vellidis, K.; Zisopoulos, I.; Bakas, G.; Chatzistavrou, T.; Karapostoli, G.; Kousouris, K.; Papakrivopoulos, I.; Siamarkou, E.; Tsipolitis, G.; Zacharopoulou, A.; Bestintzanos, I.; Evangelou, I.; Foudas, C.; Kamtsikis, C.; Katsoulis, P.; Kokkas, P.; Kioseoglou, P. G. Kosmoglou; Manthos, N.; Papadopoulos, I.; Strologas, J.; Hajdu, C.; Horvath, D.; Marton, K.; Radl, A. J.; Sikler, F.; Veszpremi, V.; Csanad, M.; Farkas, K.; Feherkuti, A.; Gadallah, M. M. A.; Kadlecsik, A.; Major, P.; Pasztor, G.; Veres, G. I.; Olah, L.; Ujvari, B.; Bencze, G.; Czellar, S.; Molnar, J.; Szillasi, Z.; Csorgo, T.; Nemes, F.; Novak, T.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chaudhary, G.; Chauhan, S.; Dhingra, N.; Kaur, H.; Kaur, M.; Kumar, S.; Sheokand, T.; Singh, J. B.; Singla, A.; Ahmed, A.; Bhardwaj, A.; Chhetri, A.; Choudhary, B. C.; Kumar, A.; Naimuddin, M.; Ranjan, K.; Saini, M. K.; Saumya, S.; Baradia, S.; Barman, S.; Bhattacharya, S.; Gupta, S. Das; Sarkar, S.; Ameen, M. M.; Behera, P. K.; Behera, S. C.; Chatterjee, S.; Dash, G.; Jana, P.; Kalbhor, P.; Kamble, S.; Komaragiri, J. R.; Kumar, D.; Mishra, T.; Parida, B.; Pujahari, P. R.; Saha, N. R.; Sharma, A.; Sikdar, A. K.; Singh, R. K.; Verma, P.; Verma, S.; Vijay, A.; Dugad, S.; Mohanty, G. B.; Parida, B.; Shelake, M.; Suryadevara, P.; Bala, A.; Banerjee, S.; Chatterjee, R. M.; Guchait, M.; Jain, Sh.; Jaiswal, A.; Kumar, S.; Majumder, G.; Mazumdar, K.; Parolia, S.; Thachayath, A.; Bahinipati, S.; Kar, C.; Maity, D.; Mal, P.; Naskar, K.; Nayak, A.; Nayak, S.; Pal, K.; Sadangi, P.; Swain, S. 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Uzbek Acad Sci, Inst Nucl Phys, Tashkent, Uzbekistan | Tuo, Shengquan/ABA-9032-2021; Gleyzer, Sergei/AAE-6726-2020; candelise, vieri/H-2195-2015; Benaglia, Andrea/AGF-5495-2022; Ulrich, Ralf/Q-3882-2019; Cunqueiro Mendez, Leticia/HJP-0371-2023; Pavlov, Borislav/O-8491-2018; Krücker, Dirk/X-1844-2019; Missiroli, Marino/AAA-9072-2021; Rossi Tisbeni, Simone/KGK-6454-2024; Fehérkuti, Anna/IQU-4197-2023; Kim, Victor/L-1648-2013; Salerno, Roberto/A-7509-2010; Cerri, Olmo/Z-3579-2019; Gonzalez, Arely/I-1034-2015; Neumeister, Norbert/JXN-1675-2024; Raidal, Martti/F-4436-2012; Rabady, Dinyar/GSN-9210-2022; Azzi, Patrizia/H-5404-2012; Lannon, Kevin/HGU-5755-2022; Kadastik, Mario/B-7559-2008; Stahl, Achim/E-8846-2011; Abdallah, Hassan/AEE-4715-2022; Shopova, Mariana/HKW-0149-2023; Dhingra, Nitish/ABA-9507-2020; Bornheim, Adi/L-2750-2019; Masciovecchio, Mario/IXD-8018-2023; Mora Herrera, Maria Clemencia/AAD-6466-2021; Juodagalvis, Andrius/F-6952-2018; Khvedelidze, Arsen/AAF-5025-2020; Chistov, Ruslan/R-5574-2019; Calvo Alamillo, Enrique/L-1203-2014; Roguljic, Matej/NMJ-5801-2025; Grzanka, Leszek/M-9052-2018; García-García, Francisco/B-1929-2014; Lorusso, Marco/LIG-7969-2024; Navarro-Tobar, Álvaro/K-7864-2014; Gomez, Jaime/P-5242-2018; Arneodo, Michele/ABF-7197-2020; Mignerey, Alice/D-6623-2011; Sonnadara, Upul/E-6359-2010; Organtini, Giovanni/D-3990-2009; Polatoz, Ayse/AAF-6722-2021; My, Salvatore/HTM-1335-2023; Petrucciani, Giovanni/AAM-8482-2020; Benussi, Luigi/O-9684-2014; Pinna Angioni, Gian Luca/AAZ-6834-2021; Paramatti, Riccardo/IXW-6363-2023; Aydilek, Orhan/GLV-0592-2022; Fiorendi, Sara/ABA-3311-2021; Canelli, Florencia/O-9693-2016; Tomei, Thiago/E-7091-2012; Trocino, Daniele/AGI-2155-2022; Dallavalle, Gaetano Marco/AFW-4654-2022; Jeitler, Manfred/H-3106-2012; Květoň, Antonín/AAA-9178-2020; Chenarani, Shirin/AAO-8918-2021; De Filippis, Nicola/AAD-6280-2019; Lange, Torben/HOH-4787-2023; Alves, Gilvan/C-4007-2013; ASILAR, Ece/KEI-3075-2024; Paoletti, Simone/R-2295-2016; KIM, Tae/P-7848-2015; 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Aimè, Chiara/GXG-4131-2022; Bunkowski, Karol/KOD-1567-2024; Gülmez, Erhan/P-9518-2015; Mundim, Luiz/A-1291-2012; Chen, Fang/JZE-4446-2024; Fanò, Livio/K-2460-2015; Heredia De La Cruz, Ivan/L-2610-2018; Delgado Peris, Antonio/AAA-5165-2019; Puerta Pelayo, Jesus/L-1632-2014; Gaile, Anastasija/KLE-1958-2024; Najafabadi, Mojtaba/AAF-7564-2019; Verwilligen, Piet/AAA-8819-2019; Mastrapasqua, Vincenzo/KZU-0967-2024; Al-Mashad, Muhammad/GYI-9445-2022; Fabozzi, Francesco/T-6468-2019; de Souza Sandro, Fonseca/ABB-8505-2020; Bedoya, Cristina/K-8066-2014; Josa, Isabel/K-5184-2014; Arcidiacono, Roberta/ABF-3918-2020; Garutti, Erika/NRY-4813-2025; Routray, Hardik/NBX-8249-2025; Hegeman, Jeroen/HJA-1005-2022; Hildreth, Michael/LWK-8035-2024; Mercadante, Pedro/K-1918-2012; Venturi, Andrea/J-1877-2012; Fiorina, Davide/HKE-5979-2023; Aarrestad, Thea/GLV-3031-2022; SIMSEK, Ali Eren/AFO-3050-2022; Stein, Annika/GLT-6049-2022; Ruhlmann-Kleider, Vanina/AGJ-4460-2022; Tumasyan, Armen/P-3390-2015; Primavera, Federica/KUD-4067-2024; De La Cruz Burelo, Eduard/AAR-9103-2021; Scodellaro, Luca/K-9091-2014; Bourilkov, Dimitri/AAO-4908-2020; Chou, Pin-Chun/HRD-5660-2023; Salvini, Paola/G-1670-2018; Bruschini, Davide/MCK-5220-2025; Bharthuar, Shudhashil/GQB-2619-2022; Osherson, Marc/LWZ-8687-2024; Watson, Ian/IAM-9344-2023; Matorras, Francisco/I-4983-2015; boccali, tommaso/ACT-7600-2022; Bouhali, Othmane/JXM-3572-2024; Doroba, krzysztof/AAA-3419-2021; Pinheiro, Joao/LMN-5088-2024; KHAN, Masood/AAA-7384-2020; Amapane, Nicola/HDN-9630-2022; Pastrone, Nadia/JRZ-0528-2023; Simone, Federica/HDM-3686-2022; Hoorani, Hafeez/D-1791-2013; Lowette, Steven/HKV-3341-2023; Voevodina, Elena/G-7314-2016; Sert, H/ABA-5645-2020; Cardini, Andrea/KUF-0984-2024; gomez, marina/I-7072-2012; Demiragli, Zeynep/IZE-1919-2023; Iaydjiev, Plamen/AEB-8785-2022; Ambrozas, Marijus/F-5551-2018; Menasce, Dario/A-2168-2016; Mishra, Trilochan/A-7947-2010; Lokos, Sandor/A-4798-2019; Felcini, Marta/S-2684-2019; Mrenna, Stephen/KIL-6081-2024; Mejia Guisao, Jhovanny/ABG-3627-2021; Giommi, Luca/AGV-7154-2022; Uslan, Ebru/ACZ-1264-2022; Malvezzi, Sandra/B-8524-2009; siviero, federico/LXA-5818-2024; Vala, Martin/HZL-1003-2023; Tadel, Matevz/H-3204-2016; Hoh, Siewyan/AAM-9562-2021; Mousa, Jehad/I-8019-2019; Ciangottini, Diego/HJH-5914-2023; Radogna, Raffaella/I-1033-2014; Laroze, David/Z-2852-2019; Csanad, Mate/D-5960-2012; Dimova, Tatyana/AAQ-9303-2021; Manganote, Edmilson/K-8251-2013; Fernandez Menendez, Javier/B-6550-2014; Morovic, Srecko/T-9019-2019; Lee, Jason/B-9701-2014; Fouz, Maria Cruz/AAF-1105-2019; Grynyov, Borys/D-1714-2010; Gavrilov, Gennadii/GRO-6222-2022; Giammanco, Andrea/O-5017-2019; Terkulov, Adel/M-8581-2015; Hall-Wilton, Richard/U-6918-2019; Bainbridge, Robert/JRW-6150-2023; Waltenberger, Wolfgang/H-9330-2018; Di Florio, Adriano/ABA-3631-2020; ciocci, maria/I-2153-2015; Yuldashev, Bekhzod/AAA-5876-2021; Mora Herrera, Clemencia/AAD-6466-2021; D'Alessandro, Raffaello/P-4138-2019; Marinelli, Nancy/MCJ-3716-2025; Escobar, Juan/JLM-3900-2023; Joo, Changwoo/ABI-4034-2020; KAYİS TOPAKSU, Aysel/B-8910-2018; Gennai, Simone/P-2880-2015; Leonidov, Andrey/P-3197-2014; Pellecchia, Antonello/KZV-0289-2024; Saini, Mukesh/C-5923-2012; Venditti, Rosamaria/IVH-5947-2023; Mota Amarilo, Kevin/JCE-6631-2023; Montanari, Alessandro/J-2420-2012; Rout, Prasanna/N-8012-2019; Faccioli, Pietro/AAF-1499-2019; Kodolova, Olga/IQV-0056-2023; Saoulidou, Niki/AAA-2891-2020; Moon, Chang-Seong/J-3619-2014; Moscatelli, Francesco/N-6333-2014; Mulders, Martijn/AGK-9612-2022; Asavapibhop, Burin/X-1477-2019; Belyaev, Andrey/E-1540-2012; Anampa, Kenyi/GPX-8479-2022; Maravin, Yurii/N-9259-2018; Caballero, Isidro/E-7354-2010; SEVINC KAYA, OZLEM/AAE-8069-2020; Tytgat, Michael/F-3732-2018; Latino, Giuseppe/AAE-7434-2019; KALINOWSKI, ARTUR/AEN-7824-2022; Obertino, Maria/ABH-1662-2020; De La Cruz Burelo, Eduard/Q-6021-2019; Di Mattia, Alessandro/HNQ-0365-2023; Vai, Ilaria/AAT-5836-2020; Sen, S./C-6473-2014; Cassese, Antonio/R-1713-2016; Palencia Cortezon, Jose Enrique/F-1059-2017; Yazgan, Efe/C-4521-2014; Chernyavskaya, Nadezda/F-2161-2015; MAESTRE, JUAN/I-5763-2015; Manca, Elisabetta/NRA-8419-2025; BARRILLON, Stephanie/ABA-6873-2021; de Paula Carvalho, Wagner/V-3343-2019; Arce, Pedro/L-1268-2014; Sagir, Sinan/A-5219-2018; Markina, Anastasia/E-3390-2012; cartiglia, nicolo/ABF-1008-2021; Ye, Sheng/HGA-5474-2022; Khakzad, Mohsen/ABB-1945-2021; Padula, Sandra/AAE-4304-2020; Wimpenny, Stephen/K-8848-2013; Kirakosyan, Martin/N-2701-2015; Rivero, Celso/V-6916-2017; Safronov, Grigory/F-8494-2017; Chistov, Ruslan/B-4893-2014; Majumder, Gobinda/MTB-7852-2025; Negrini, Matteo/C-8906-2014; Theofilatos, Konstantinos/AAL-9162-2021; Bin Yusuff, Imran/ABA-5986-2020; Singh, J B/IXD-2130-2023; Baskakov, Alexey/O-4521-2017; Quijada, Javier/AAS-4234-2021; LECOQ, Paul/S-7246-2019; Govoni, Pietro/K-9619-2016 | EUROPEAN PHYSICAL JOURNAL C | EUR PHYS J C | 1434-6044 | 1434-6052 | 85 | 3 | SCIE | PHYSICS, PARTICLES & FIELDS | 2024 | 4.8 | 24.2 | 0 | English | 2025 | 2025-03-25 | 10.1140/epjc/s10052-024-13729-y | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | ○ | Article | Stability of psychotic symptoms and safety in switching to aripiprazole once-monthly according to prior oral antipsychotic drugs | Long-acting injectable aripiprazole has substantiated safety and efficacy in treating schizophrenia. However, interindividual variability in clinical response to aripiprazole, possibly linked to its D2 partial agonism and D2 upregulation due to prior antipsychotics, has been reported. This study assessed whether there would be symptomatic aggravations or adverse events in clinically stable patients with schizophrenia when switching from oral antipsychotics to aripiprazole once-monthly (AOM), considering prior antipsychotics: oral aripiprazole (Group I) or other D2 antagonists (Group II). This was a 20-week, prospective, open-label, multicenter trial. Clinically stable patients with schizophrenia were assigned to two groups based on their oral antipsychotic medication and received AOM every 4 weeks. The primary endpoint was a change from baseline in the total Positive and Negative Syndrome Scale (PANSS) score. Treatment-emergent adverse events (TEAEs) were monitored. Altogether, 100 patients in Group I and 101 in Group II completed the study. The mean changes (+/- SD) from baseline in PANSS total score after switching to AOM were-9.43 +/- 9.79 in Group I (p < 0.0001) and-4.04 +/- 8.72 in Group II (p = 0.0102). Compared to Group I, in Group II, more sleep disturbance (p = 0.0243) and psychotic symptoms (p = 0.0042) TEAE emerged after AOM initiation, with both TEAEs resolving during the study. Psychotic symptoms TEAE was associated with faster tapering of the prior oral antipsychotics (p = 0.0269). Initiating AOM did not aggravate symptoms. Furthermore, AOM ameliorated psychotic symptoms without any significant adverse effect, regardless of their prior oral antipsychotics. However, patients previously treated with D2 antagonists may experience transient psychiatric TEAEs that can be minimized with longer cross-titration. | Kim, Euitae; Kim, Seoyoung; Kim, Sung-Wan; Nam, Beom-Woo; Lee, Kyoung-Uk; Lee, Bong Ju; Won, Seung-Hee; Lee, Chang Hwa; Jung, Sung Won; Kim, Soo In; Cho, Sung Joon; Chung, Young-Chul; Choi, Tai Kiu; Cheon, Eun-Jin; Baek, Ji Hyun; Correll, Christoph U.; Kwon, Jun Soo | Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam, Gyeonggi Do, South Korea; Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju, South Korea; Konkuk Univ, Sch Med, Chungju Hosp, Dept Psychiat, Chungju, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Psychiat, Uijongbu, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Psychiat, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Eulji Univ, Eulji Univ Hosp, Sch Med, Dept Psychiat, Daejeon, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Psychiat, Daegu, South Korea; Ewha Womans Univ, Coll Med, Dept Psychiat, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, Seoul, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Psychiat, Jeonju, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Psychiat, Songnam, Gyeonggi Do, South Korea; Yeungnam Univ, Coll Med, Med Ctr, Dept Psychiat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat, Seoul, South Korea; Northwell Hlth, Zucker Hillside Hosp, Dept Psychiat, Glen Oaks, NY USA; Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA; Charite Univ Med Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany; German Ctr Mental Hlth DZPG, Partner Site, Berlin, Germany; Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, Seoul, South Korea; Hanyang Univ Hosp, Dept Psychiat, Seoul, South Korea | Chung, Young/AAB-8242-2022; Baek, Ji Hyun/JJF-8250-2023 | 55756823600; 57201720091; 47962371200; 47761464600; 7501503004; 59053777300; 35278955600; 56021899500; 57211573327; 55998772900; 57212144380; 55712695800; 59898892400; 57079780200; 59911106100; 7003584103; 59867451000 | kwonjs@snu.ac.kr; | SCHIZOPHRENIA RESEARCH | SCHIZOPHR RES | 0920-9964 | 1573-2509 | 281 | SCIE;SSCI | PSYCHIATRY | 2024 | 3.5 | 24.5 | 0 | 2025-06-11 | 0 | 0 | Schizophrenia; Aripiprazole; Up-regulation; Dopamine | DOPAMINE SUPERSENSITIVITY PSYCHOSIS; LONG-TERM EFFECTIVENESS; DOUBLE-BLIND; MAINTENANCE TREATMENT; PARTIAL AGONIST; SCHIZOAFFECTIVE-DISORDER; 1ST-EPISODE PSYCHOSIS; ADJUNCTIVE TREATMENT; NATIONWIDE COHORT; RATING-SCALE | Aripiprazole; Dopamine; Schizophrenia; Up-regulation | Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Drug Administration Schedule; Drug Substitution; Female; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Treatment Outcome; Young Adult; aripiprazole; clozapine; dopamine; neuroleptic agent; aripiprazole; neuroleptic agent; adult; adverse event; anxiety; Article; disease duration; drug efficacy; drug safety; drug tolerability; electrocardiogram; electroconvulsive therapy; extrapyramidal symptom; female; follow up; human; male; mood disorder; multicenter study; Positive and Negative Syndrome Scale; prospective study; psychiatrist; psychosis; schizophrenia; sensitivity analysis; sleep disorder; suicidal ideation; upregulation; clinical trial; drug administration; drug substitution; drug therapy; middle aged; oral drug administration; psychological rating scale; schizophrenia; treatment outcome; young adult | English | 2025 | 2025-07 | 10.1016/j.schres.2025.04.033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microwave-assisted synthesis of solketal from glycerol and acetone in the presence of SAPO-34 and SAPO-5 | Solketal is one of the most promising additives improving the properties of motor fuels. Investigations related to process intensification of synthesis of solketal from glycerol and acetone is gaining importance. The present work illustrates the use of the microwave mode for intensification of this process in the presence of silicoaluminophosphates (SAPO) as catalysts. The main focus of the study was placed on tuning the textural, acidic, and catalytic properties of SAPO-34 and SAPO-5 via variation of the synthesis parameters, such as the nature of Al and Si sources and the structure-directing agent. The catalytic properties of SAPO materials were investigated in the synthesis of solketal from glycerol and acetone under microwave assistance at the acetone/glycerol molar ratio of 2.4 in a methanol solution (glycerol/methanol: 1 g/1 mL) and 56 degrees C. It was demonstrated that the selectivity towards solketal was 91.1-98.6 % in the presence of the studied materials. The activities of mesoporous SAPO-34 and SAPO-5 prepared in the presence of triethylamine were higher as compared with micro- porous SAPO-34 prepared in the presence of tetraethylammonium hydroxide due to the high mesoporosity and a larger content of acid sites. The 90.4 % conversion of glycerol and 98.6 % selectivity towards solketal were observed in the presence of mesoporous 7.6%SAPO-34 for 90 min. The advantage of using microwave technology is shown. The solketal yield in the reaction under microwave irradiation was 3 times higher than that in the process performed under thermal heating conditions. | Makova, Anna S.; Panchenko, Valentina N.; Bolotov, Vasilii A.; Davshan, Nikolai A.; Mishin, Igor V.; Timofeeva, Maria N.; Shefer, Kristina I.; Ter-Akopyan, Marina; Kustov, Leonid M.; Jhung, Sung Hwa | RAS, ND Zelinsky Inst Organ Chem, Leninsky Prospect 47, Moscow 119991, Russia; RAS, GK Boreskov Inst Catalysis SB, Prospekt Akad Lavrentieva 5, Novosibirsk 630090, Russia; Natl Univ Sci & Technol MISIS, Leninsky Prospect 4, Moscow 119049, Russia; Kyungpook Natl Univ, Dept Chem, DaeHak Ro 80, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, DaeHak Ro 80, Daegu 41566, South Korea | ; Jhung, Sung/AAO-6683-2021; Makova, Anna/GRR-8810-2022; Kustov, Leonid/L-4071-2014; Shefer, Kristina/D-3648-2014; Panchenko, Valentina/D-1068-2014; Timofeeva, Maria/E-9277-2012 | 57217018059; 7102133466; 36501167700; 37060643500; 7004616332; 7005428141; 16231089500; 59141781700; 7005973628; 6701659467 | timofeeva@catalysis.ru; lmk@ioc.ac.ru; | MICROPOROUS AND MESOPOROUS MATERIALS | MICROPOR MESOPOR MAT | 1387-1811 | 1873-3093 | 381 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 4.7 | 24.7 | 0 | 2025-05-07 | 0 | 0 | Solketal; Glycerol; Acetone; Microwave irradiation; SAPO-34; SAPO-5 | SILICOALUMINOPHOSPHATE MOLECULAR-SIEVES; TRANSITION-METAL IONS; ALUMINOPHOSPHATE; IRRADIATION; CONVERSION; LOCATION; METHANOL; HSAPO-34; ACIDITY | Acetone; Glycerol; Microwave irradiation; SAPO-34; SAPO-5; Solketal | Automotive fuels; Fuel additives; Irradiation; Mesopores; Mesoporous materials; Microporous materials; Microwave materials processing; Catalytic properties; Mesoporous; Microwave assisted synthesis; Microwave- irradiations; Property; Silicoaluminophosphate-34; Silicoaluminophosphate-5; Silicoaluminophosphates; Solketal; Molar ratio | English | 2025 | 2025-01-01 | 10.1016/j.micromeso.2024.113361 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Terpenoids and steroids from aerial parts of Achillea alpina L. as PTP1B inhibitors: Kinetic analysis and molecular docking studies | Achillea alpina L. (Alpine yarrow) is a noteworthy herb in the genus Achillea with many uses in vegetables and traditionally used to treat stomach disorders. In our continuous research on the chemical constituents and biological activities of medicinal plants, ten previously undescribed terpenoids including eight eudesmane-type sesquiterpenes (1-8), one nor-eudesmane-type sesquiterpene (9), one cyclo-geraniol derivative (10), and twentyone known compounds were isolated and structurally elucidated from the aerial parts of A. alpina. Structures and absolute configurations of the undescribed terpenoids were identified using comprehensive spectroscopic analysis (NMR, HRESI-MS, and CD data) and computational methods (ECD and NMR calculation). Enzyme inhibitory assays showed that the isolated sesquiterpene (19), triterpene (22), and sterol (26) were protein tyrosine phosphatase 1B (PTP1B) inhibitors with IC50 values ranging from 14.87 to 23.09 mu M in comparison with positive control - ursolic acid, showing IC50 value of 5.93 +/- 0.16 mu M. Further enzyme kinetics and molecular docking studies were performed to provide valuable insights into their mechanism of action. | Le, Thi Thanh; Ha, Manh Tuan; Lee, Gyu Sung; Nguyen, Viet Phong; Kim, Chung Sub; Kim, Jeong Ah; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyongsan 38430, Gyeongbuk, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Sungkyunkwan Univ, Dept Biopharmaceut Convergence, Suwon 16419, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC, Daegu 41566, South Korea | Nguyen, Viet Phong/AAQ-4207-2021; Kim, Chung Sub/GLN-7192-2022; Tuan, Ha/AAW-5444-2021 | 57350699400; 57189040434; 58125379500; 57205196739; 12142324700; 24722570900; 55663638200 | chungsub.kim@skku.edu; jkim6923@knu.ac.kr; bsmin@cu.ac.kr; | PHYTOCHEMISTRY | PHYTOCHEMISTRY | 0031-9422 | 1873-3700 | 229 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES | 2024 | 3.4 | 24.7 | 4.49 | 2025-05-07 | 3 | 3 | Achillea alpina; Asteraceae; Terpenoids; Eudesmanes; PTP1B | CHEMICAL-CONSTITUENTS; SESQUITERPENOIDS | Achillea alpina; Asteraceae; Eudesmanes; PTP1B; Terpenoids | Achillea; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Molecular Docking Simulation; Molecular Structure; Plant Components, Aerial; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Steroids; Structure-Activity Relationship; Terpenes; enzyme inhibitor; protein tyrosine phosphatase 1B; PTPN1 protein, human; steroid; terpene; Achillea; aerial plant part; chemical structure; chemistry; dose response; human; isolation and purification; kinetics; molecular docking; structure activity relation | English | 2025 | 2025-01 | 10.1016/j.phytochem.2024.114269 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | First clinical report of the international single-port robotic rectal cancer registry | Background: Rectal cancer surgery remains a significant technical challenge. The development and implementation of a new technology offer hope for more accurate and precise surgery. To evaluate whether singleport robotic (SPr) technology helps achieve this goal, an international SPr registry was established. This study reported short-term clinical and oncologic outcomes from an international SPr registry for rectal cancer. Methods: A review of a prospective international registry of SPr technology approved for colorectal surgery with an investigational design exemption was conducted. Patients with rectal adenocarcinoma who had resection for curative intent using the SPr platform between November 2018 and September 2022 were included. Frequency statistics described patient and tumor characteristics and intraoperative, oncologic, and clinical outcome variables. The main outcome measure was the quality of the total mesorectal excision (TME) specimen. The secondary outcome measures were intraoperative conversion and 30-day postoperative morbidity and mortality. Results: A total of 113 SPr procedures for rectal cancer were performed at 2 centers by 4 colorectal surgeons. Of note, 9 local excisions were excluded, leaving 104 cases analyzed. The cohort consisted of 53 men (50.96%), had a mean age of 60.00 years (SD, 11.29), and had a body mass index of 25.80 kg/m2 (SD, 6.18). The most common T stage was 3 (55 [52.8%]), followed by 2 (19 [18.26%]). More than 60% of patients had preoperative neoadjuvant chemoradiation. The mean tumor distance from the anorectal ring was 2.90 cm (SD, 2.62), and the mean tumor size was 4.52 cm (SD, 1.82). The procedures performed included transanal abdominal transanal/transanal TME (52 [46%]), low anterior resection (49 [43.3%]), and abdominoperineal resection (3 [2.7%]). The mean operating time was 168.0 min (SD, 56.9). There were no intraoperative complications and 2 (1.9%) conversions to laparoscopy. There was a median of 2 incisions, with a mean size of 2.30 cm (SD, 1.31). The TME specimens were complete in 101 cases (97.1%) and near complete in 3 cases (2.9%). The R1 rate was 3.8%, with 3 positive distal margins and 1 positive circumferential margin. Postoperatively, there were 15 total complications, of which 4 were major complications and 11 were minor complications. There were 2 readmissions (ileus and small bowel obstruction). There were no mortalities. Conclusion: This early international experience with the SPr procedure showed that it is a safe and effective technique for distal rectal cancers, with excellent specimen quality. The complication and conversion rates observed with other techniques and platforms used in rectal cancer surgery were not demonstrated. An international registry was used to better understand the opportunities and limitations of SPr technology in rectal cancer surgery as the technology is adopted and applied more widely. Although structured training and controlled trials will be required to develop best practices and define the use of the SPr technology, initial international registry data are encouraging. (c) 2024 Published by Elsevier Inc. on behalf of Society for Surgery of the Alimentary Tract. | Marks, John H.; Kim, Hye Jin; Choi, Gyu-Seog; Idrovo, Luis Andres; Chetty, Suraj; De Paula, Thais Reif; Keller, Deborah | Lankenau Inst Med Res, Lankenau Med Ctr, Dept Surg, Wynnewood, PA 19096 USA; Lankenau Inst Med Res, Lankenau Med Ctr, Wynnewood, PA 19096 USA; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Surg Oncol Serv, Soc Lucha Canc Ecuador, Pichincha, Ecuador | Reif de Paula, Thais/AEA-1061-2022; Kim, Hye/W-1059-2019 | 55423905100; 57204567554; 8058759100; 6505878255; 59309036800; 58312227300; 55559681100 | marksj@mlhs.org; | JOURNAL OF GASTROINTESTINAL SURGERY | J GASTROINTEST SURG | 1091-255X | 1873-4626 | 29 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2024 | 2.4 | 24.8 | 0 | 2025-05-07 | 0 | 0 | Colon cancer; Complications; Rectal cancer; Single-port robot; Total mesorectal excision | LAPAROSCOPIC-ASSISTED RESECTION; SPHINCTER PRESERVATION SURGERY; TOTAL MESORECTAL EXCISION; SHORT-TERM OUTCOMES; PATHOLOGICAL OUTCOMES; TUMOR-REGRESSION; COLON-CANCER; COLECTOMY; CHEMORADIOTHERAPY; COMPLICATIONS | Colon cancer; Complications; Rectal cancer; Single-port robot; Total mesorectal excision | Adenocarcinoma; Aged; Conversion to Open Surgery; Female; Humans; Male; Middle Aged; Operative Time; Postoperative Complications; Proctectomy; Prospective Studies; Rectal Neoplasms; Registries; Robotic Surgical Procedures; Treatment Outcome; adenocarcinoma; aged; clinical trial; conversion to open surgery; epidemiology; female; human; male; middle aged; multicenter study; operation duration; pathology; postoperative complication; procedures; proctectomy; prospective study; rectum tumor; register; robot assisted surgery; surgery; treatment outcome | English | 2025 | 2025-02 | 10.1016/j.gassur.2024.101929 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Intercomparison of radar data assimilation systems for snowfall cases during the ICE-POP 2018 | This study compares two data assimilation (DA) methods, the Local Ensemble Transform Kalman Filter (LETKF) and three-dimensional variational analysis (3DVAR), in the assimilation of high-resolution three-dimensional remote sensing data. Different observation operators are applied to each DA method to reflect its specific characteristics and to provide best analysis for precipitation forecast over complex terrain. Since radial velocity has a linear relationship with wind components, it applies relatively easily to both DA methods. However, reflectivity has a nonlinear relationship with model state variables and LETKF applies direct DA, while 3DVAR uses indirect DA. A detailed analysis of two specific snowfall cases using ICE-POP 2018 observational data reveals significant differences in wind field changes. In 3DVAR, strong convergence on the windward side and the rapid growth of water vapor into hydrometeors during the forecast period lead to an overestimation of precipitation. In contrast, LETKF improves the simulation of airflow over mountains and enhances precipitation accuracy, attributed to the background error covariance matrix and observation operator. For accurate winter precipitation forecasts over complex terrain, high-resolution data and advanced DA techniques like LETKF are necessary, as they greatly improve snowfall prediction accuracy. | Lee, Ji-Won; Min, Ki-Hong; Chung, Kao-Shen; You, Cheng-Rong; Ke, Chieh-Ying; Lee, Gyuwon | Kyungpook Natl Univ, Dept Atmospher Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Atmospher Remote Sensing, Daegu 41566, South Korea; Kyungpook Natl Univ, Weather Extremes Educ & Res Team BK21, Daegu 41566, South Korea; Natl Cent Univ, Dept Atmospher Sci, Jhongli 320, Taiwan; Cent Weather Adm, Taipei 100006, Taiwan | Lee, Jiwon/JVZ-0286-2024; Chung, Kao-Shen/ABF-3546-2020 | 55780416700; 37089364100; 8049218900; 57219295907; 57206668583; 7404852271 | kmin@knu.ac.kr; | ATMOSPHERIC RESEARCH | ATMOS RES | 0169-8095 | 1873-2895 | 314 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 4.4 | 24.8 | 0 | 2025-05-07 | 0 | 0 | Radar data assimilation; Three-dimensional variational data assimilation; Local ensemble transform Kalman filter data assimilation; Observation operator; Complex terrains precipitation forecasts | ENSEMBLE KALMAN FILTER; REFLECTIVITY DATA ASSIMILATION; BULK PARAMETERIZATION; MODEL; PRECIPITATION; IMPACT; SCALE; MICROPHYSICS; SIMULATION; WEATHER | Complex terrains precipitation forecasts; Local ensemble transform Kalman filter data assimilation; Observation operator; Radar data assimilation; Three-dimensional variational data assimilation | Covariance matrix; Snow; Complex terrain precipitation forecast; Complex terrains; Data assimilation; Data assimilation methods; Local ensemble transform kalman filter data assimilation; Observation operator; Precipitation forecast; Radar data assimilation; Three-dimensional variational data-assimilation; Variational analysis; complex terrain; data assimilation; Kalman filter; precipitation (climatology); radar; snow; Kalman filters | English | 2025 | 2025-03 | 10.1016/j.atmosres.2024.107804 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Risk of myocardial infarction and stroke in patients with keloids: A nationwide population-based cohort study | Background: Keloids represent a form of benign fibroproliferative disorder. Prior studies have linked various fibroproliferative conditions to an increased cardiovascular disease risk; however, the relationship between keloids and major adverse cardiovascular events, such as myocardial infarction (MI) and stroke, remains inadequately explored. A comprehensive nationwide population-based cohort approach was used to examine the cardiovascular disease risk in patients with keloids. Methods: The cohort comprised 554,501 patients with keloid and 1,109,002 matched controls. Primary measures included the incidence rates and incidence rate ratios of MI, ischemic stroke (IS), and hemorrhagic stroke (HS) compared to the matched controls. The study applied a stratified Cox regression hazard model to compute the relative hazards between patients with keloid and the controls. Results: Incidence rate ratios for cardiovascular diseases in patients with keloid, relative to controls, were 1.08 (95% confidence interval [CI], 1.06-1.10) for MI, 1.06 (CI, 1.04-1.08) for IS, and 1.05 (CI, 1.01-1.08) for HS. After adjusting for additional cardiovascular risk factors, a persistent elevated risk for MI and IS was evident in patients with keloid with adjusted hazard ratios (HRs) of 1.04 (CI 1.01-1.07) for MI and 1.03 (CI 1.00-1.07) for IS. Stratified analyses by age, sex, body mass index, and smoking status revealed consistent risk elevations in older individuals (>= 50 years), women, obese individuals, and nonsmokers. Conclusions: Keloids are associated with a significant increase in MI and IS risk, independent of the traditional cardiovascular risk factors. This association is particularly prominent in older adults, women, obese individuals, and nonsmokers. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. | Jo, Taehee; Jeong, Woonhyeok; Ryu, Jeong Yeop | Keimyung Univ, Sch Med, Dongsan Hosp, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea | ; Ryu, Jeong Yeop/GLQ-9419-2022 | 57219222858; 56701910000; 56366349400 | prsryu@knu.ac.kr; | JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY | J PLAST RECONSTR AES | 1748-6815 | 1878-0539 | 105 | SCIE | SURGERY | 2024 | 2.4 | 24.8 | 0 | 2025-05-07 | 0 | 0 | Keloid; Myocardial infarction; Ischemic stroke; Hemorrhagic stroke; Cardiovascular diseases | SYSTEMIC-SCLEROSIS; HYPERTENSION | Cardiovascular diseases; Hemorrhagic stroke; Ischemic stroke; Keloid; Myocardial infarction | Adult; Aged; Case-Control Studies; Cohort Studies; Female; Hemorrhagic Stroke; Humans; Incidence; Ischemic Stroke; Keloid; Male; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Risk Factors; Stroke; Taiwan; cholesterol; glucose; acute heart infarction; adult; Article; atrial fibrillation; body mass; brain hemorrhage; cardiovascular risk; cardiovascular risk factor; cerebrovascular accident; cholesterol blood level; cohort analysis; controlled study; cumulative incidence; diagnostic accuracy; diastolic blood pressure; fasting blood glucose level; female; follow up; highest income group; human; hypercholesterolemia; hyperglycemia; hypertension; ICD-10; ischemic stroke; keloid; lowest income group; major clinical study; male; medical photography; medical record review; middle income group; non-smoker; obesity; prevalence; sensitivity and specificity; smoking; systolic blood pressure; validation study; aged; brain hemorrhage; case control study; complication; epidemiology; etiology; heart infarction; incidence; ischemic stroke; middle aged; proportional hazards model; risk factor; Taiwan | English | 2025 | 2025-06 | 10.1016/j.bjps.2025.03.034 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | TRMM-era neural networks for GPM-era satellite quantitative precipitation estimation (QPE) | Quantitative Precipitation Estimates (QPE) obtained from satellite data are essential for accurately assessing the hydrological cycle in both land and ocean. Early artificial Neural Networks (NN) methods were used previously either to merge infrared and microwave data or to derive better precipitation products from radar and radiometer measurements. Over the last 25 years, machine learning technology has advanced significantly, accompanied by the initiation of new satellites, such as the Global Precipitation Measurement Mission Core Observatory (GPM-CO). In addition, computing power has increased exponentially since the beginning of the 21st century. This paper compares the performance of a pure NN FORTRAN, originally designed to expedite the 2A12 TRMM (Tropical Rainfall Measuring Mission) algorithm, with a contemporary state-of-the-art NN in Python using the TensorFlow library (NN PYTHON). The performance of FORTRAN and Python approaches to QPE using GPM-CO data are compared with the goal of achieving a minimum NN architecture that at least matches the outcome of the Goddard Profiling Algorithm (GPROF) algorithm. Another conclusion is that the new NN PYTHON does not present significant advantages over the old FORTRAN code. The latter does not require dependencies, which has many practical advantages in operational use and therefore have an edge over more complex approaches in hydrometeorology. | Leganes, Livia J.; Navarro, Andres; Lee, Gyuwon; Martin, Raul; Kidd, Chris; Tapiador, Francisco J. | Univ Castilla La Mancha, Inst Environm Sci ICAM, Dept Environm Sci, Earth & Space Sci ess Res Grp, Toledo, Spain; Kyungpook Natl Univ, Ctr Atmospher REmote sensing CARE, Dept Astron & Atmospher Sci, Daegu, South Korea; Univ Castilla La Mancha, Dept Math, Optimal Expt Design DOE Grp, Toledo, Spain; Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD USA; NASA Goddard Space Flight Ctr GSFC, Greenbelt, MD USA | Kidd, Christopher/AFS-9145-2022; Martin Martin, Raul/F-2331-2016; Tapiador, Francisco/D-2781-2009 | 59349023200; 57193451684; 7404852271; 58867259000; 7005206687; 6602960153 | francisco.tapiador@uclm.es; | ATMOSPHERIC RESEARCH | ATMOS RES | 0169-8095 | 1873-2895 | 315 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 4.4 | 24.8 | 4.93 | 2025-05-07 | 1 | 1 | Quantitative precipitation estimates; Neural network; GPM; Remote sensing; GPROF; FORTRAN; PYTHON | PASSIVE MICROWAVE; RADAR MEASUREMENTS; RAINFALL; RESOLUTION; INVERSION; MODEL | FORTRAN; GPM; GPROF; Neural network; PYTHON; Quantitative precipitation estimates; Remote sensing | FORTRAN (programming language); Microwave measurement; Precipitation (meteorology); Problem oriented languages; Rain gages; Stockpile surveys; Time difference of arrival; Tropics; FORTRAN; Global precipitation measurements; Goddard profiling algorithms; GPM; Neural-networks; Performance; Quantitative precipitation estimate; Quantitative precipitation estimation; Remote-sensing; Tropical rainfall measuring missions; algorithm; artificial neural network; comparative study; precipitation assessment; quantitative analysis; remote sensing; satellite data; satellite imagery; TRMM; Python | English | 2025 | 2025-04-01 | 10.1016/j.atmosres.2024.107879 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A2-Astrocyte Activation by Short-Term Hypoxia Rescues α-Synuclein Pre-Formed-Fibril-Induced Neuronal Cell Death | Background/Objectives: Parkinson's disease (PD) is a neuro-degenerative disease for which a radical cure is not available, only symptomatic control. Studies have shown that hypoxia may have disease-modifying effects on PD. Methods: Herein, we investigated whether short-term hypoxia activates astrocytes and whether it has a protective effect on pre-formed fibril (PFF)-treated primary cortical neurons. Results: Long-term hypoxia suppresses astrocyte activation and induces cell death, whereas short-term hypoxia activates astrocytes without affecting cellular apoptosis or viability. Short-term hypoxia restored the cellular apoptosis and viability of PFF-treated neurons and reduced toxic phospho-alpha-synuclein (p-alpha-syn) aggregation. Similarly, the short-term hypoxia-exposed astrocyte-conditioned medium rescued cellular apoptosis and the viability of PFF-treated neurons and p-alpha-syn expression. Quantitative polymerase chain reaction revealed that short-term hypoxia promotes protective A2 astrocytes and suppresses toxic A1 astrocytes. Conclusions: Our findings suggest that short-term hypoxia has a neuro-protective effect against PD by activating protective A2 astrocytes, which rescue PFF-induced neuronal cell death. This provides insights into the clinical implications of short-term hypoxia as a disease-modifying PD strategy. | Choi, Ha Nyeoung; Kim, Seon-Hee; Jo, Min Gi; Lee, Bina; Kim, Young Jin; Lee, So Eun; Lee, Jeong Hyun; Seong, Hye Min; Kim, Seong Jae; Park, Sang Won; Kim, Hye Jung; Kang, Heeyoung; Lee, Chan Hyun; Lee, Min Young; Yun, Seung Pil; Kim, Minkyeong | Gyeongsang Natl Univ, Inst Med Sci, Coll Med, Dept Pharmacol, Jinju 52727, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Convergence Med Sci, Jinju 52727, South Korea; Kyung Hee Univ, Coll Med, Dept Pathol, Seoul 02447, South Korea; Gyeongsang Natl Univ, Inst Hlth Sci, Coll Med, Dept Ophthalmol, Jinju 52727, South Korea; Gyeongsang Natl Univ Hosp, Dept Neurol, Jinju 52727, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Neurol, Jinju 52727, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr VOICE,MRC, Daegu 41566, South Korea | Kim, Young-jin/GSD-3168-2022 | 59131798800; 59104096700; 57204517713; 55839741900; 59132011800; 59420498400; 58932698400; 56585536200; 55578336500; 56588162900; 55793607500; 56549268500; 57410017800; 15119890400; 25951635400; 57203524825 | phsl123@naver.com; seonhkim@gnu.ac.kr; mingi.jo@khu.ac.kr; iibina@naver.com; dog020@naver.com; seuu12@naver.com; uranus-jh@hanmail.net; seong_hm@daum.net; maya12kim@naver.com; parksw@gnu.ac.kr; hyejungkim@gnu.ac.kr; miranda75@naver.com; princekittyryan@gmail.com; vetmedic@knu.ac.kr; spyun@gnu.com; doctorminmd@gmail.com; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 13 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 1 | 1 | Parkinson's disease (PD); hypoxia; astrocyte; neuronal death; pre-formed fibril | MITOCHONDRIAL; DYSFUNCTION; ASTROCYTES | astrocyte; hypoxia; neuronal death; Parkinson’s disease (PD); pre-formed fibril | English | 2025 | 2025-03-01 | 10.3390/biomedicines13030604 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Deep Sea Minerals Ameliorate Dermatophagoides Farinae- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice | Background: Chronic pruritus and inflammatory skin lesions, characterized by high recurrence, are hallmarks of atopic dermatitis (AD). Despite its increasing prevalence, the development of therapeutic agents for AD remains limited. This study aimed to evaluate the therapeutic effects of deep sea minerals (DSMs) in mist and cream formulations on the development of AD-like skin lesions in NC/Nga mice exposed to either Dermatophagoides farinae body extract (Dfb) or 2,4-dinitrochlorobenzene (DNCB). Methods: To induce AD, 100 mg of Biostir AD cream containing crude Dfb or 200 mu L of DNCB (1%) was topically applied to the dorsal skin of NC/Nga mice. Additionally, 200 mu L of deep sea mineral mist (DSMM) and 10 mg of deep sea mineral cream (DSMC) were applied daily to the dorsal skin for 4 weeks. AD was assessed through visual observations, clinical scoring of skin severity, serological tests, and histological analysis. Results: Visual and clinical evaluations revealed that DSMs inhibited the formation of AD-like skin lesions. DSMs also significantly affected trans-epidermal water loss and erythema. Treatment with DSMs resulted in reduced serum levels of IgE, IFN-gamma, and IL-4. Histological analysis indicated that DSMs decreased skin thickness. Immunostaining for the CD4 antigen demonstrated a reduced infiltration of CD4+ T cells, which drive the Th2 response in AD, following DSM treatment. Conclusions: In conclusion, the cream formulation of DSMs showed better results than the mist formulation. These results suggest that DSMs may be an effective treatment for AD-like skin lesions, especially in cream formulation. | Kim, Hyo Sang; Kim, Myeong Hwan; Jeon, Byeong Yeob; Jang, You Kyung; Kim, Jeong Ki; Song, Hyun Keun; Kim, Kilsoo | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Qualified Bio & Minerals Co Ltd, Seoul 06752, South Korea; MEDI Co Ltd, Okcheon eup, Okcheon 29040, Chungcheongbug, South Korea | 59756239400; 58351376100; 58864175800; 59589878100; 59755729500; 8062949700; 35272034300 | poppingboys@naver.com; meong125678@naver.com; byjeon01@qbm.co.kr; ykjang01@qbm.co.kr; drks1kim@gmail.com; kali71@hanmail.net; kskim728@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 13 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 0 | 0 | deep sea mineral; inflammation; IgE; anti-atopic dermatitis | MOUSE MODEL; INHIBITS DEVELOPMENT; ANIMAL-MODELS; DUST MITES; WATER; INFLAMMATION; MAGNESIUM; ACCUMULATION; EXPRESSION; MIXTURE | anti-atopic dermatitis; deep sea mineral; IgE; inflammation | English | 2025 | 2025-04-02 | 10.3390/biomedicines13040861 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Engagement of CD300c by a Novel Monoclonal Antibody Ameliorates Behavioral Deficits in a 5xFAD Mouse Model of Alzheimer's Disease | Background: Current treatment modalities for Alzheimer's disease (AD), which is characterized by the accumulation of amyloid beta (A beta), have limitations with regard to their efficacy and safety, posing significant challenges for advances in healthcare. However, recent studies indicated that AD can be treated using monocyte-derived macrophages (MDMs). Reportedly, the protein CD300c regulates monocyte differentiation, indicating that targeting CD300c could offer a treatment for AD. Methods: To confirm this, we developed CB201, a fully human anti-CD300c antibody, and demonstrated its strong and specific binding to CD300c using surface plasmon resonance and binding ELISAs. Results: Treatment of THP-1 and human peripheral blood mononuclear cells with CB201 led to increased levels of pro-inflammatory cytokines and the differentiation of macrophages to MDMs. Moreover, the CB201-differentiated macrophages expressed cytokines and chemokines in a pattern that alleviates AD symptoms. In a 5xFAD mouse model, CB201 treatment improved memory and behavior in both the early and late stages of AD and reduced cerebral A beta plaque load. Conclusions: These results indicate that CB201 promotes the differentiation of macrophages to MDMs and modulates AD-related inflammatory responses, thereby ameliorating the pathological features of AD. These findings identify CD300c as a potential therapeutic target for AD and indicate that CB201 is a promising candidate for its treatment. | Lee, Suin; Lim, Chang Ki; Kim, Jongyeob; Kim, Joon; Jin, Hee Kyung; Bae, Jae-sung; Jeon, Jae-Won | CentricsBio Inc, 3F BK tower,28,Beobwon ro 11 gil, Seoul 05836, South Korea; Kyungpook Natl Univ, Dept Lab Anim Med, Coll Vet Med, Daegu 37224, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 37224, South Korea | Bae, Jae-sung/AAM-8663-2021 | 58787291700; 58787998300; 59917291600; 59917766900; 8088145800; 35209510400; 58787998400 | jwjeon@centricsbio.com; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 13 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-06-11 | 0 | 0 | Alzheimer's disease; monocyte-derived macrophage; macrophage differentiation; CD300c; 5xFAD; amyloid beta; Morris water maze | AMYLOID-BETA; MEMORY; MICE | 5xFAD; Alzheimer’s disease; amyloid β; CD300c; macrophage differentiation; monocyte-derived macrophage; Morris water maze | English | 2025 | 2025-05-10 | 10.3390/biomedicines13051169 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Advancements in bone malignancy research through next-generation sequencing focussed on osteosarcoma, chondrosarcoma, and Ewing sarcoma | Next-generation sequencing (NGS) technologies have revolutionized bone cancer research, enabling detailed insights into the genetic, transcriptional, and epigenetic layers of these malignancies. This overview discusses the pivotal role of NGS in enhancing the diagnosis, prognosis, and treatment of primary bone cancers such as osteosarcoma, chondrosarcoma, and Ewing sarcoma. By facilitating the identification of novel genetic mutations, gene fusions, and epigenetic alterations, NGS supports the development of personalized medicine approaches and targeted therapies, significantly impacting clinical outcomes. The utilization of various NGS platforms, including Illumina, SOLiD, and Ion Torrent, has provided comprehensive genomic profiles that inform targeted treatment strategies and enable early detection through liquid biopsies and circulating tumor DNA (ctDNA) analysis. Despite the profound clinical benefits, the integration of NGS into routine practice faces challenges such as technical limitations, complex data interpretation, and substantial infrastructure requirements. Future directions involve technological improvements, combinatorial omics approaches, and extensive validation through clinical trials to confirm the efficacy of NGS-guided interventions. These advancements promise to further enhance the precision and effectiveness of bone cancer management, offering hope for more tailored and effective therapeutic outcomes. | Jeyaraman, Naveen; Jeyaraman, Madhan; Subramanian, Preethi; Ramasubramanian, Swaminathan; Balaji, Sangeetha; Muthu, Sathish; Rajendran, Ramya Lakshmi; Gangadaran, Prakash | Dr MGR Educ & Res Inst, ACS Med Coll & Hosp, Dept Orthopaed, Chennai 600077, Tamil Nadu, India; Orthopaed Res Grp, Dept Res Methods, Coimbatore 641045, Tamil Nadu, India; Virginia Tech India, Chennai 600095, Tamil Nadu, India; Apollo Proton Canc Ctr, Dept Radiat Oncol, Chennai 600041, Tamil Nadu, India; Govt Med Coll, Dept Orthopaed, Omandurar Govt Estate, Chennai 600002, Tamil Nadu, India; Karpagam Acad Higher Educ, Fac Engn, Dept Biotechnol, Coimbatore 641021, Tamil Nadu, India; Govt Med Coll, Dept Orthopaed, Karur 639004, Tamil Nadu, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea | Ramasubramanian, Swaminathan/ISA-0083-2023; Jeyaraman, Madhan/ABB-8464-2020; Muthu, Sathish/G-5756-2018; Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021 | 57219306833; 57216926503; 59758086800; 58960264000; 58993757300; 57217850874; 57195318729; 54393130400 | madhanjeyaraman@gmail.com; ramyag@knu.ac.kr; prakashg@knu.ac.kr; | PATHOLOGY RESEARCH AND PRACTICE | PATHOL RES PRACT | 0344-0338 | 1618-0631 | 269 | SCIE | PATHOLOGY | 2024 | 3.2 | 25.0 | 0 | 2025-05-07 | 0 | 0 | Bone cancer; Next-generation sequencing; Personalized medicine; Genetic mutations; Liquid biopsy; Targeted therapy | MANAGEMENT | Bone cancer; Genetic mutations; Liquid biopsy; Next-generation sequencing; Personalized medicine; Targeted therapy | Biomarkers, Tumor; Bone Neoplasms; Chondrosarcoma; High-Throughput Nucleotide Sequencing; Humans; Osteosarcoma; Precision Medicine; Sarcoma, Ewing; tumor marker; bone tumor; chondrosarcoma; diagnosis; Ewing sarcoma; genetics; high throughput sequencing; human; osteosarcoma; pathology; personalized medicine; procedures; therapy | English | 2025 | 2025-05 | 10.1016/j.prp.2025.155908 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comprehensive welfare assessment of Eurasian otters (Lutra lutra) in South Korean Zoos using the modified Animal Welfare Assessment Grid (AWAG) and hair cortisol concentration | Animal welfare means meeting animals' physical and psychological needs, minimizing suffering, and supporting their adaptation to the environment. It can be assessed based on an integration of animal-based and resource-based indicators, with additional evaluation of stress levels using physiological measure. Assessing animal welfare helps identify influencing factors, develop strategies for welfare improvement, and detect health issues early. This study aimed to assess the welfare of 17 Eurasian otters (Lutra lutra) housed in eight enclosures across six zoos (five large public zoos and one indoor interactive zoo) in South Korea, identify factors affecting their welfare status, and analyze welfare factors related to chronic stress, ultimately proposing effective improvement strategies. A modified Animal Welfare Assessment Grid (AWAG) was used to evaluate 34 factors across four welfare sections: physical, psychological, environmental, and procedural. Hair cortisol concentrations (HCCs) were measured in 12 Eurasian otters for evaluating chronic stress level. The average welfare scores were as follows: physical (1.65), psychological (3.24), environmental (2.53), and procedural (5.27), with procedural welfare recording the highest score. This was primarily attributed to physical restraint and the high visitor numbers typical of large public zoos. A significant positive correlation between restraint and training (p < 0.01) suggests that positive reinforcement training can help mitigate the negative effects of physical restraint. The indoor interactive enclosure had the highest overall welfare scores, with high psychological scores due to stereotypic behavior and high environmental scores from poor conditions. Abnormal behavior showed positive correlations with environmental factors such as shelter, materials, location suitability, and furnishing/design (p < 0.05). These findings suggest that improving environmental conditions may contribute to reducing stress and enhancing psychological welfare. Another enclosure, which had the second highest overall score, showed particularly high physical and procedural scores. These outcomes were influenced by an individual that died due to disease, highlighting the importance of individualized welfare assessments and regular health monitoring. The average HCC was 18.47 +/- 33.64 pg/mg (median: 8.37 pg/mg, range: 5.31-124.89 pg/mg), with no significant correlation observed with any welfare factors. One individual with a prolonged disease exhibited a relatively high HCC, along with high scores in related physical and procedural factors. While this single case does not allow for generalization, it may suggest a potential association between chronic health conditions and elevated stress levels, warranting further investigation. Future research should include zoos with diverse conditions and refine hair sampling method to better identify welfare factors affecting chronic stress and provide strategies to enhance welfare of Eurasian otters. | Kim, Jee Hyun; Kang, Hyejin; Min, Mi-Sook; Ma, Seung Aee; Cho, Je-Yoel | Seoul Natl Univ, Res Inst Vet Sci, Coll Vet Med, Seoul 08826, South Korea; Conservat Genome Resource Bank Korean Wildlife, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju 37224, South Korea; Korean Wildlife Welf & Conservat Res Inst, Gong Zone, Anyang 14035, South Korea; Cheongju Univ, Dept Anim Hlth & Welf, Cheongju 28503, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Coll Vet Med, Dept Biochem, Seoul 08826, South Korea; Seoul Natl Univ, BK21 FOUR Future Vet Med Leading Educ & Res Ctr, Seoul 08826, South Korea; Seoul Natl Univ, Comparat Med Dis Res Ctr CDRC, Seoul 08826, South Korea | Kim, Jee/F-8777-2012 | 57712432300; 57706440100; 7005546715; 57706439900; 59475347500 | kjhsonic@hanmail.net; aeesea@cju.ac.kr; jeycho@snu.ac.kr; | APPLIED ANIMAL BEHAVIOUR SCIENCE | APPL ANIM BEHAV SCI | 0168-1591 | 1872-9045 | 288 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;BEHAVIORAL SCIENCES;VETERINARY SCIENCES | 2024 | 2 | 25.0 | 0 | 2025-06-11 | 0 | 0 | Eurasian otter; Animal welfare assessment grid; Hair cortisol; Chronic stress; Zoo animal welfare; Captive animal | STRESS; BEHAVIOR; CONSEQUENCES; ENRICHMENT; DESIGN; BLOOD | Animal welfare assessment grid; Captive animal; Chronic stress; Eurasian otter; Hair cortisol; Zoo animal welfare | South Korea; adaptation; animal welfare; captive population; environmental conditions; hormone; oxidative stress; small mammal; stereotypic behavior; zoo | English | 2025 | 2025-07 | 10.1016/j.applanim.2025.106665 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study | Background To evaluate the mortality patterns of SLE and the associated risk factors in Koreans.Methods Using the National Health Insurance database spanning 2008 to 2018, incident cases of SLE in patients aged 10-79 years were included. We analysed the all-cause mortality and cause-specific mortality, stratifying by sex and age. The mortality rate (MR) was calculated as the number of deaths per 100 000 person-years (PYs). The causes of death were identified by the International Classification of Diseases, 10th Revision codes during hospitalisation or emergency visit prior to death. A generalised estimating equation model was employed for risk factor analysis.Results In total, 11 375 incident SLE cases among patients with an average age of 42.3 +/- 16.7 years were recruited (86.1% female). During 57 658 PYs, 728 deaths occurred (MR 1262.62/100 000 PYs). The MR among men (2718.86/100 000 PYs) exceeded that among women (1060.57/100 000 PYs). The leading causes of death were SLE-related conditions (381.56/100 000 PYs), cardiovascular disease (CVD) (202.92/100 000 PYs), cancer (175.17/100 000 PYs) and infection (143.95/100 000 PYs). Of the SLE-related mortality, the key risk factors were pulmonary complications, such as pulmonary alveolar haemorrhage (OR 9.93), pulmonary arterial hypertension (OR 3.77) and interstitial lung disease (OR 3.27).Conclusions Among Korean patients with SLE, SLE-related conditions were the leading causes of mortality. However, CVD and cancer were also identified as the main causes of mortality. Furthermore, pulmonary manifestations were significantly associated with SLE-related mortality. | Cho, Soo-Kyung; Jeon, Yena; Kim, Jung-hyo; Jang, Eun Jin; Jung, Sun-Young; Sung, Yoon-Kyoung | Hanyang Univ, Dept Rheumatol, Hosp Rheumat Dis, Seoul, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Andong Natl Univ, Dept Data Sci, Andong, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea | 35185890800; 57209909350; 59659721500; 37861741600; 57207445502; 15754508900 | skchomd@hanyang.ac.kr; yeahnah@naver.com; julie6002@naver.com; jejstat@gmail.com; jsyoung@cau.ac.kr; sungyk@hanyang.ac.kr; | LUPUS SCIENCE & MEDICINE | LUPUS SCI MED | 2053-8790 | 12 | 1 | SCIE | RHEUMATOLOGY | 2024 | 3.5 | 25.0 | 0 | 2025-05-07 | 1 | 1 | Systemic Lupus Erythematosus; Mortality; Risk Factors | SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYOCARDIAL-INFARCTION; DEATH; HYPERTENSION; POPULATION; DAMAGE | Mortality; Risk Factors; Systemic Lupus Erythematosus | azathioprine; cyclophosphamide; cyclosporine; glucocorticoid; hydroxychloroquine; leflunomide; methotrexate; mycophenolate mofetil; add on therapy; adult; aged; all cause mortality; antiphospholipid syndrome; Article; cardiovascular disease; Charlson Comorbidity Index; child; cohort analysis; comorbidity; congestive heart failure; controlled study; death toll; diabetes mellitus; female; follow up; human; hyperlipidemia; hypertension; ICD-10; immunosuppressive treatment; incidence; interstitial lung disease; Korean (people); lung complication; lung hemorrhage; major clinical study; male; malignant neoplasm; middle aged; mortality; mortality rate; national health insurance; observational study; opportunistic infection; prescription; pulmonary hypertension; retrospective study; risk factor; systemic lupus erythematosus | English | 2025 | 2025-02-25 | 10.1136/lupus-2024-001361 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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