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○ ○ Article ⓘ Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study ⓘ Introduction: Guideline-discordant low-dose computed tomography (LDCT) screening may cause lung cancer (LC) overdiagnosis, but its extent and consequences are unclear. This study aimed to investigate the prevalence of self-initiated, non-reimbursed LDCT screening in a predominantly non-smoking population and its impact on LC epidemiology and healthcare utilization. Methods: This nationwide cohort study analyzed data from Korea's National Health Information Database and 11 academic hospital screening centers (1999-2022). The overall analysis encompassed the entire Korean population. For non-reimbursed LDCT screening prevalence, which the National Health Information Database does not capture, a separate analysis was conducted on a cohort of 1.7 million adults to extrapolate nationwide rates. Outcomes included trends in self-initiated, non-reimbursed LDCT screening, LC incidence, mortality, stage and age at diagnosis, 5-year survival, and LC-related healthcare utilization, including surgeries and biopsies. Joinpoint regression assessed trend changes. Results: Self-initiated, non-reimbursed LDCT screening during health check-ups increased from 29% to 60% in men and 7% to 46% in women, despite only 2.4% of men and 0.04% of women qualifying for risk-based screening. In women, localized-stage LC incidence nearly doubled (age-standardized incidence rate: from 7.6 to 13.7 per 100,000), whereas distant-stage incidence decreased (age-standardized incidence rate: from 16.1 to 15.0 per 100,000). LC mortality declined (age-standardized mortality rate: from 23.3 to 19.8 per 100,000), whereas 5-year survival rates improved substantially. LC diagnoses in women shifted towards earlier stages and younger ages. Lung surgeries for both malignant and benign lesions, frequently lacking nonsurgical biopsies, increased sharply in women. Conclusions: Widespread guideline-discordant LDCT screening correlates with LC overdiagnosis and increased healthcare utilization, particularly in women. Randomized controlled trials are needed to assess the risks and benefits of screening in low-risk populations to determine its efficacy and consequences. (c) 2024 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. ⓘ Kim, So Yeon; Silvestri, Gerard A.; Kim, Yeon Wook; Kim, Roger Y.; Um, Sang-Won; Im, Yunjoo; Hwang, Jung Hye; Choi, Seung Ho; Eom, Jung Seop; Gu, Kang Mo; Kwon, Yong-Soo; Lee, Shin Yup; Lee, Hyun Woo; Park, Dong Won; Heo, Yeonjeong; Jang, Seung Hun; Choi, Kwang Yong; Kim, Yeol; Park, Young Sik ⓘ Seoul Natl Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea; Med Univ South Carolina, Div Pulm & Crit Care Med, Charleston, SC USA; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Seongnam, South Korea; Univ Penn, Dept Med, Div Pulm Allergy & Crit Care Med, Philadelphia, PA USA; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Pulm & Crit Care Med,Dept Med, Seoul, South Korea; Samsung Med Ctr, Ctr Hlth Promot, Seoul, South Korea; Seoul Natl Univ Hosp, Healthcare Res Inst, Healthcare Syst Gangnam Ctr, Dept Internal Med, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Div Resp & Crit Care, Seoul Metropolitan Govt,Boramae Med Ctr, Seoul, South Korea; Hanyang Univ, Dept Internal Med, Div Pulm Med & Allergy, Coll Med, Seoul, South Korea; Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Pulm Allergy & Crit Care Med, Anyang, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Control, Goyang, South Korea ⓘ Um, Sang/F-4610-2014; Choi, Seung/C-4314-2013; Im, Yunjoo/KTI-2428-2024; Kim, Roger/AAL-4562-2021; Gu, Kang-Mo/GRR-9015-2022; Kwon, Yong-Soo/AAH-6718-2019; Park, Young Sik/MBG-1896-2025 ⓘ 57213778426; 7102565287; 57964938700; 57211011032; 7005044020; 57204092023; 22953295200; 56939444900; 57201262394; 57226782283; 55721979700; 49863712700; 57205720858; 57222481997; 57215904827; 7402219050; 59911137300; 57658915700; 57222878541 ⓘ mdyspark@snu.ac.kr; ⓘ JOURNAL OF THORACIC ONCOLOGY ⓘ J THORAC ONCOL ⓘ 1556-0864 1556-1380 20 5 SCIE ONCOLOGY;RESPIRATORY SYSTEM ⓘ 2024 20.8 2.3 1.65 2025-05-07 ⓘ 4 4 Lung cancer; Screening; Overdiagnosis; Health-care utilization ⓘ QUALITY-OF-LIFE; NEVER-SMOKERS; PERMUTATION TESTS; RISK-FACTORS; COMPLICATIONS; EPIDEMIOLOGY; BRONCHOSCOPY; SIGNATURES; RESECTION; LESIONS ⓘ Healthcare utilization; Lung cancer; Overdiagnosis; Screening ⓘ Adult; Aged; Cohort Studies; Early Detection of Cancer; Female; Humans; Lung Neoplasms; Male; Middle Aged; Overdiagnosis; Patient Acceptance of Health Care; Republic of Korea; Tomography, X-Ray Computed; adult; Article; cohort analysis; confidence interval; controlled study; female; health care utilization; human; incidence; Korean (people); low risk population; lung cancer; major clinical study; male; mortality rate; overdiagnosis; prevalence; randomized controlled trial; smoking; survival rate; aged; diagnosis; diagnostic imaging; early cancer diagnosis; epidemiology; lung tumor; middle aged; patient attitude; procedures; South Korea; x-ray computed tomography ⓘ English 2025 2025-05 10.1016/j.jtho.2024.12.006 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Turbulence-enhanced microneedle immunoassay platform (TMIP) for high-precision biomarker detection from skin interstitial fluid ⓘ Conventional diagnostic methods for biomarker detection often require invasive procedures and exhibit limited reproducibility and sensitivity. In this study, the turbulence-enhanced microneedle immunoassay platform (TMIP) was designed to enhance the performance and accuracy of biomarker detection in skin interstitial fluid (ISF). TMIP combines a bullet-shaped microneedle (MN) array for minimally invasive biomarker capture, a microfluidic device for MN-mediated immunoassay process simplification, and a star-shaped magnetic stirrer tool (MST) to facilitate efficient washing. By targeting S100 calcium-binding protein B (S100B), a diagnostic biomarker for melanoma, TMIP demonstrated substantial improvements in reproducibility, reducing signal deviations by up to 55 % compared to manual operation. The application of nanoporous MNs (NPMNs) achieved a low detection limit of 20 pg/mL with a high linearity (R2 = 0.9758). Validation using a gelatin phantom mimicking human skin confirmed TMIP's ability to achieve improved reproducibility and sensitivity. Furthermore, TMIP successfully detected S100B with high reproducibility in both the phantom (R2 = 0.97523) and melanoma-expressing mice within a rapid incubation time of 1 min. TMIP enables the detection of biomarkers with remarkable reproducibility and sub-nanogram sensitivity by simplifying the analysis process and enhancing reagent washing through turbulence. These features suggest that TMIP has the potential to serve as an efficient and reliable tool for biomarker detection in skin ISF. ⓘ Yang, Ju-Hong; Seong, Keum-Yong; Kang, Mingi; Jang, Sangsoo; Yang, Seung Yun; Hahn, Young Ki ⓘ Kyungpook Natl Univ, Adv Inst Sci & Technol, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Pusan Natl Univ, Life & Ind Convergence Inst, Dept Biomat Sci, BK21 Program 4, Miryang 50463, South Korea; Kyungpook Natl Univ, Dept Adv Bioconvergence, BK21 Program 4, Daegu 41566, South Korea ⓘ ⓘ 59748365200; 56473397700; 59748521600; 58958763900; 57571328800; 16052846700 ⓘ syang@pusan.ac.kr; hahnv@knu.ac.kr; ⓘ BIOSENSORS & BIOELECTRONICS ⓘ BIOSENS BIOELECTRON ⓘ 0956-5663 1873-4235 282 SCIE BIOPHYSICS;CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;NANOSCIENCE & NANOTECHNOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 10.5 2.3 0 2025-05-07 ⓘ 0 0 Biosensor; Microneedle; Melanoma; Turbulence generation; Enhancing precision ⓘ PROTEIN ⓘ Biosensor; Enhancing precision; Melanoma; Microneedle; Turbulence generation ⓘ Animals; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Equipment Design; Extracellular Fluid; Humans; Immunoassay; Limit of Detection; Melanoma; Mice; Needles; Reproducibility of Results; S100 Calcium Binding Protein beta Subunit; Skin; Biomarkers; Dermatitis; Dermatology; Phantoms; aluminum; biological marker; gelatin; high precision biomarker; immunoglobulin E; immunoglobulin G; iron oxide; phosphoric acid; unclassified drug; biological marker; protein S100B; S100B protein, human; tumor marker; Diagnostic methods; Enhancing precision; High-precision; Interstitial fluids; Melanoma; Microneedle arrays; Microneedles; Performance; Reproducibilities; Turbulence generation; animal experiment; animal model; Article; controlled study; fluorescence intensity; geometry; immunoassay; interstitial fluid; magnetic field; melanoma; mouse; nonhuman; reproducibility; skin interstitial fluid; turbulence enhanced microneedle immunoassay platform; animal; chemistry; devices; diagnosis; equipment design; extracellular fluid; genetic procedures; human; immunoassay; isolation and purification; limit of detection; melanoma; metabolism; needle; skin; Needles ⓘ English 2025 2025-08-15 10.1016/j.bios.2025.117480 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Bio-Mediated Flocculation of Freshwater Microplastics: Effects of Microalgae With Exopolymer Attachments ⓘ Transparent exopolymer particles (TEPs) are crucial for enhancing the flocculation of microplastics (MPs). However, quantitatively evaluating the influence of TEP on the flocculation process and addressing these effects in a flocculation model are challenging. In this study, three freshwater microalgae (Scenedesmus sp., Aulacoseira granulata, and Melosira varians) with various levels of TEP production were incubated to investigate the biologically mediated flocculation process with MPs in a mixing chamber. The results revealed that the three microalgal species significantly increased flocculation, with floc size increasing notably (one-way analysis of variance, p value < 0.001) at later incubation periods (12, 16, 20, 24, and 30 days), compared with the early incubation periods (after 6 and 9 days), when TEP production was lower. A critical TEP concentration (0.42 mg/L) was observed, beyond which further increases in TEP production had minimal effects on the flocculation process. Among the selected microalgae, the Scenedesmus sp.-MPs mixture presented a faster floc growth rate than Aulacoseira granulata and Melosira varians. Furthermore, a modified population balance equation model was proposed to incorporate the ratio of the TEP concentration to the microplastic concentration into the aggregation and maximum specific growth rate parameters. The modified model revealed that the floc growth rate and equilibrium mean size are dependent on the TEP concentration when the MP concentration is fixed, which is in good agreement with the experimental data. The modified model illustrates the potential to simulate exopolymer-driven interactions between microalgae and MPs and provides insights into the mechanisms of bio-mediated flocculation. ⓘ Zhang, Jianwei; Shen, Xiaoteng; Robins, Peter; Li, Xiaorong; Lee, Byung Joon; Bi, Qilong; Zhang, Ying; Chen, Qiqing; Zhang, Jisheng ⓘ Hohai Univ, Natl Key Lab Water Disaster Prevent, Nanjing, Peoples R China; Hohai Univ, Jiangsu Key Lab Coast Ocean Resources Dev & Enviro, Nanjing, Peoples R China; Bangor Univ, Ctr Appl Marine Sci, Sch Ocean Sci, Bangor, Wales; Kyungpook Natl Univ, Dept Environm & Safety Engn, Sangju, South Korea; Deltares, Coastal & Marine Syst, Delft, Netherlands; Jiangxi Water Resources Inst, Nanchang, Peoples R China; East China Normal Univ, State Key Lab Estuarine & Coastal Res, Shanghai, Peoples R China ⓘ ⓘ 59917104800; 56449797600; 56652418200; 57104824100; 56016052400; 56542803900; 59823930100; 46760891800; 57211582663 ⓘ xiaoteng.shen@hhu.edu.cn; ⓘ WATER RESOURCES RESEARCH ⓘ WATER RESOUR RES ⓘ 0043-1397 1944-7973 61 5 SCIE ENVIRONMENTAL SCIENCES;LIMNOLOGY;WATER RESOURCES ⓘ 2024 5 2.4 0 2025-06-11 ⓘ 0 0 microplasitcs; flocculation; microalgae; transparent exopolymer particles; population balance model ⓘ PARTICLES TEP; FLOC SIZE; QUADRATURE METHOD; PHYTOPLANKTON; DYNAMICS; TURBULENT; ESTUARY; MATTER; RESUSPENSION; EFFICIENCY ⓘ flocculation; microalgae; microplasitcs; population balance model; transparent exopolymer particles ⓘ Flocculation; Listeria; Salmonella; SARS; Exopolymers; Flocculation process; Micro-algae; Microalga; Microplasitcs; Microplastics; Particle production; Particles concentration; Population balance modelling; Transparent exopolymer particles; flocculation; freshwater environment; growth rate; microalga; plastic waste; population dynamics; transparent exopolymer particle; Microalgae ⓘ English 2025 2025-05 10.1029/2024wr039115 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Letter ⓘ Mineral surface area of sinking particles in the deep ocean interior: Preliminary implications ⓘ Measurement of the mineral surface area (MSA) of sedimentary particles is a traditional approach for studying the transport and protection of organic carbon (OC) in marine systems. We investigated the application of MSA on the biological carbon pump in the deep ocean interior in the Ulleung Basin (UB), East/Japan Sea. This is the second study of sinking particle MSA, and the first in an ocean with no major riverine (terrestrial) input. We measured seasonal and vertical variations in the MSA of sinking particles and adjacent surface sediments in the UB. Mineral surface area values exhibit seasonal variations associated with particle composition, with a negative correlation with OC content and a strong positive correlation with the content of lithogenic material and the radiocarbon values of sinking OC. Our results indicate that the MSA of sinking particles may provide clues to the processes of particle resuspension and decomposition. ⓘ Kim, Minkyoung; Blattmann, Thomas M.; Lin, Baozhi; Lee, Sun-A; Montlucon, Daniel B.; Eglinton, Timothy I. ⓘ Kyungpook Natl Univ, Dept Oceanog, KNU G LAMP Project Grp, Daegu, South Korea; Swiss Fed Inst Technol, Geol Inst, Zurich, Switzerland; Tongji Univ, State Key Lab Marine Geol, Shanghai, Peoples R China ⓘ ; Lin, Baozhi/HMD-3263-2023; Blattmann, Thomas/AFT-2488-2022 ⓘ 57212315624; 57194522271; 56905107800; 59463822700; 7801384591; 57203175556 ⓘ minkyoung@knu.ac.kr; ⓘ LIMNOLOGY AND OCEANOGRAPHY LETTERS ⓘ LIMNOL OCEANOGR LETT ⓘ 2378-2242 10 3 SCIE LIMNOLOGY;OCEANOGRAPHY ⓘ 2024 5 2.4 0 2025-05-07 ⓘ 0 0 ⓘ BIOLOGICAL HOT-SPOT; ORGANIC-CARBON; ULLEUNG BASIN; AMINO-ACIDS; SEDIMENTS; MATTER; SEA; ADSORPTION; EXPORT; FATE ⓘ ⓘ ⓘ English 2025 2025-06 10.1002/lol2.10450 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ miRNA-214 to predict progression and survival in ALS ⓘ Background Reliable biomarkers are essential for predicting the progression speed and prognosis of patients with amyotrophic lateral sclerosis (ALS). We previously identified NCK-associated protein 1 (NCKAP1) as a critical factor in the defective phagocytosis observed in induced microglia-like cells (iMGs) from patients with rapidly progressive sporadic ALS. This study explored the roles of microRNA (miRNA)-214, which targets the NCKAP1 gene, in the progression of ALS.Methods The discovery cohort (n=29) was used to identify miR-214 targeting NCKAP1 genes. The validation cohort (n=132) was used to determine the clinical usability of miR-214 for predicting disease progression speed and survival time.Results In the discovery cohort, miR-214 levels were increased in plasma and iMGs from rapidly progressive ALS participants. This finding was validated in another cohort of 132 ALS participants and 30 age-matched healthy volunteers. Plasma miR-214 levels correlated with disease progression, severity and survival, distinguishing between rapidly progressive and slowly progressive ALS. In addition, miR-214 levels also correlated with plasma neurofilament light chain (NfL) and cerebrospinal fluid inflammatory cytokines, showing specific associations with increased NfL and monocyte chemoattractant protein 1 (MCP-1). Survival prediction accuracy improved when miR-214 levels were considered with NfL or MCP-1 levels.Conclusions Plasma miRNA-214 could serve as a novel biomarker for predicting the progression and prognosis of ALS. ⓘ Noh, Min-Young; Kwon, Min-Soo; Oh, Ki-wook; Nahm, Minyeop; Park, Jinseok; Jin, Hee Kyung; Bae, Jae-sung; Son, Bugyeong; Kim, Seung Hyun ⓘ Hanyang Univ, Coll Med, Dept Neurol, Seoul, South Korea; Hanyang Univ, Med Ctr, Cell Therapy Ctr, Seoul, South Korea; CHA Univ, Res Inst Basic Med Sci, Sch Med, Dept Pharmacol, Pangyo, Gyeonggi, South Korea; Chemon Inc, Gyeonggi Bio Res Ctr, Suwon, Gyeonggi, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu, South Korea; Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu, South Korea; Hanyang Univ, Dept Publ Hlth Sci, Coll Med, Seoul, South Korea; Neurology,Brown University Warren Alpert Medical School,USA; MRC Centre for Neuromuscualr Diseases,National Hospital of Neurology and Neurosurgery,UK ⓘ Bae, Jae-sung/AAM-8663-2021; KIM, Seung Hyun/T-5133-2017; Kwon, Minsoo/J-8725-2014; Oh, Ki-wook/E-6996-2017 ⓘ 15758187600; 7103154477; 55337510100; 15061944000; 57202928365; 58950699500; 35209510400; 57862065000; 57204797945 ⓘ nmy@hanyang.ac.kr; minsoo100@cha.ac.kr; kiwook-oh@hanyang.ac.kr; nmy92@kbri.re.kr; jinseok.park0@gmail.com; hkjin@mail.knu.ac.kr; jsbae@knu.ac.kr; sonbugyeong@hanyang.ac.kr; kimsh1@hanyang.ac.kr; ⓘ JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY ⓘ J NEUROL NEUROSUR PS ⓘ 0022-3050 1468-330X 96 7 SCIE CLINICAL NEUROLOGY;SURGERY;PSYCHIATRY ⓘ 2024 7.5 2.4 5.44 2025-05-07 ⓘ 2 2 Personal Satisfaction; ALS ⓘ PROGNOSTIC BIOMARKER ⓘ ALS; Personal Satisfaction ⓘ Adaptor Proteins, Signal Transducing; Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Cohort Studies; Cytokines; Disease Progression; Female; Humans; Male; Microglia; MicroRNAs; Middle Aged; Neurofilament Proteins; Prognosis; biological marker; microRNA; microRNA 214; monocyte chemotactic protein 1; NCK associated protein 1; protein; tumor necrosis factor; unclassified drug; biological marker; cytokine; microRNA; MIRN214 microRNA, human; neurofilament protein; neurofilament protein L; signal transducing adaptor protein; adult; amyotrophic lateral sclerosis; area under the curve; Article; blood sampling; cerebrospinal fluid; clinical article; cohort analysis; controlled study; disease duration; disease exacerbation; disease severity; family history; female; gene; human; male; microglia; middle aged; neurofilament; phagocytosis; plasma; prediction; survival; survival time; whole exome sequencing; aged; blood; disease exacerbation; genetics; metabolism; mortality; prognosis ⓘ English 2025 2025-02-01 10.1136/jnnp-2024-335177 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Plant-derived nanovesicles and therapeutic application ⓘ Plant-derived nanovesicles (PDNVs) are becoming more popular as promising therapeutic tools owing to their diversity, cost-effectiveness, and biocompatibility with very low toxicity. Therefore, this review aims to discuss the methods for isolating and characterizing PDNVs and emphasize their versatile roles in direct therapeutic applications and drug delivery systems. Their ability to effectively encapsulate and deliver large nucleic acids, proteins, and small-molecule drugs was highlighted. Moreover, advanced engineering strategies, such as surface modification and fusion with other vesicles, have been developed to enhance the therapeutic effects of PDNVs. Additionally, we describe key challenges related to this field, encouraging further research to optimize PDNVs for various clinical applications for prevention and therapeutic purposes. The distinctive properties and diverse applications of PDNVs could play a crucial role in the future of personalized medicine, fostering the development of innovative therapeutic strategies. (c) 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). ⓘ Jung, Dokyung; Kim, Na-Eun; Kim, Sua; Bae, Ju-Hyun; Jung, Il-Young; Doh, Kyung-Won; Lee, Byungheon; Kim, Do-Kyun; Cho, Young-Eun; Baek, Moon-Chang ⓘ Kyungpook Natl Univ, Exosome Convergence Res Ctr ECRC, Sch Med, Dept Mol Med,CMRI, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea; Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea ⓘ ⓘ 57207487580; 59675031700; 59674841000; 57225046295; 59675031800; 59673885200; 16304374900; 57442742600; 56390104900; 7006013097 ⓘ mcbaek@knu.ac.kr; ⓘ PHARMACOLOGY & THERAPEUTICS ⓘ PHARMACOL THERAPEUT ⓘ 0163-7258 1879-016X 269 SCIE PHARMACOLOGY & PHARMACY ⓘ 2024 12.5 2.4 0 2025-05-07 ⓘ 2 4 Plant-derived nanovesicles; Isolation methods; Therapeutic agents; Drug delivery systems; Therapeutic applications ⓘ EXOSOME-LIKE NANOVESICLES; EXTRACELLULAR VESICLES; BREAST-CANCER; NANOPARTICLES; MICRORNAS; INHIBIT; CELLS; PROLIFERATION; DOXORUBICIN; MATURATION ⓘ Drug delivery systems; Isolation methods; Plant-derived nanovesicles; Therapeutic agents; Therapeutic applications ⓘ Animals; Drug Carriers; Drug Delivery Systems; Humans; Nanoparticles; Plants; drug carrier; nanoparticle; biocompatibility; cost effectiveness analysis; drug administration; drug delivery device; drug delivery system; drug therapy; human; nonhuman; personalized medicine; pharmaceutics; prevention; review; therapy; animal; chemistry; plant; procedures ⓘ English 2025 2025-05 10.1016/j.pharmthera.2025.108832 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome ⓘ Hutchinson-Gilford progeria syndrome (HGPS), an extremely rare progressive genetic disorder, is caused by a point mutation in LMNA that induces progerin production, which disrupts cellular function and triggers premature aging and mortality. Despite extensive efforts, HPGS remains incurable. We successfully implemented a strategy using RfxCas13d to selectively target progerin mRNA at specific junction regions, without unintended cleavage and reduce its expression. This technique discriminated between normal lamin A and progerin, thus providing a safe and targeted therapeutic avenue to treat HGPS. Our approach effectively restored aberrant gene expression and progerin-induced cellular phenotypes, including senescence, mitochondrial dysfunction, and DNA damage in cells with HGPS and LMNAG608G/G608G mice. Notably, LMNAG608G/G608G mice exhibited improved progeroid phenotypes, suggesting a potential therapeutic application of this approach for other diseases resulting from abnormal RNA splicing. © 2025 The Authors ⓘ Chae, Unbin; Yang, Hae-Jun; Kim, Hanseop; Lee, Seung Hwan; Lee, Dong Gil; Koo, Jeong Young; Ha, Seung-Min; Bak, Seo-Jong; Joo, Mina; Nam, Hyun Hee; Lim, Kyung-Seob; Kang, Philyong; Son, Hee-Chang; An, You Jeong; Kim, Young-Hyun; Song, In-Sung; Lee, Sang-Hee; Kim, Hae Rim; Cho, Sang-Mi; Kim, Eun-Kyoung; Nam, Ki-Hoan; Chung, Kyung-Sook; Kim, Jae-Yoon; Kim, Seon-Yeop; Kim, Seon-Kyu; Kim, Seon-Young; Lee, Dong-Seok; Kim, Jin-Man; Park, Young-Ho; Kim, Sun-Uk ⓘ Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Department of Life Science, Chung-Ang University, Seoul, 06974, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Pathology, Chungnam National University College of Medicine, Daejeon, South Korea; Department of Pathology, Chungnam National University College of Medicine, Daejeon, South Korea; Department of Pathology, Chungnam National University College of Medicine, Daejeon, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Department of Biomedical Sciences, College of Medicine, Ulsan University, Asan Medical Center, Seoul, South Korea; Center for Bio-imaging and Translational Research, Korea Basic Science Institute (KBSI), Cheongju, South Korea; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Center for Gene and Cell Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea, Department of Advanced Bioconvergence, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea; Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea, Department of Bioinformatics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea, Department of Bioinformatics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea, Department of Bioinformatics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; School of Life Sciences and Biotechnology, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, South Korea; Department of Pathology, Chungnam National University College of Medicine, Daejeon, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea ⓘ ⓘ 56414782600; 56247333900; 57203630238; 57202327400; 59968831800; 59969318500; 59758990800; 59968739900; 57212102120; 59969030100; 59758765300; 56720870900; 57212457098; 59968740000; 54393408600; 59114646100; 58743241400; 57211990062; 59968930600; 57201091885; 55750745700; 59637933000; 57190048273; 59968740100; 13410554000; 59969318600; 57210068061; 59915253200; 56246852400; 59740169700 ⓘ jinmank@cnu.ac.kr; pyh2877@kribb.re.kr; sunuk@kribb.re.kr; ⓘ Molecular Therapy ⓘ MOL THER ⓘ 1525-0016 1525-0024 SCIE GENETICS & HEREDITY;MEDICINE, RESEARCH & EXPERIMENTAL;BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 12 2.4 ⓘ 0 ⓘ ⓘ Hutchinson-Gilford progeria syndrome; lamin A; mis-splicing; progerin; RfxCas13d ⓘ ⓘ English Article in press 2025 10.1016/j.ymthe.2025.06.017 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ A PUF-Based Lightweight Authentication Scheme for UAV-Assisted Internet of Vehicles ⓘ Unmanned Aerial Vehicles (UAVs)-assisted Internet of Vehicles (IoV) utilizes flexible mobility of UAVs to improve communication issues in traditional IoV model. In UAV-assisted IoV, UAVs expand the communication coverage of roadside units (RSUs) and support the tasks of RSUs. Therefore, UAV-assisted IoV can contribute to the development of Intelligent Transportation System (ITS). However, an adversary can still attempt various attacks because UAV-assisted IoV networks perform wireless communication over open channels. In 2024, Miao et al. proposed an elliptic curve cryptography (ECC)-based authentication scheme for UAV-assisted IoV. Unfortunately, we discover that their scheme cannot prevent man-in-the-middle (MITM) and ephemeral secret leakage (ESL) attacks. Furthermore, Miao et al.’s scheme incurs high computational costs using ECC which is unfavorable for UAVs considering their computational restrictions. In this article, we propose a secure and lightweight authentication scheme for UAV-assisted IoV, considering the computational limitations of UAVs. We apply physical unclonable function (PUF) and fuzzy extractor to mutual authentication, developing the security level. Moreover, the proposed scheme uses only one-way hash functions and exclusive-or (XOR) operations which are compatible with UAVs. To prove the robustness of the proposed scheme, we perform “Burrows-Abadi-Needham (BAN) logic”“, Real-or-Random (RoR) model”, and “Automated Verification of Internet Security Protocols and Applications (AVISPA)” based formal security analysis, and informal analysis. Furthermore, we estimate the performance of the proposed scheme and compare with other relevant works, including computational costs, communication costs, energy consumption, security properties, and storage costs. Consequently, we establish that the proposed scheme is appropriate and efficient for UAV-assisted IoV. © 2000-2011 IEEE. ⓘ Choi, Jihye; Kwon, Deokkyu; Son, Seunghwan; Park, Yohan; Das, Ashok Kumar; Park, Youngho ⓘ Kyungpook National University, School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University, School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University, School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Keimyung University, School of Computer Engineering, Daegu, 42601, South Korea; International Institute of Information Technology, Center for Security, Theory and Algorithmic Research, Hyderabad, 500032, India; Kyungpook National University, School of Electronic and Electrical Engineering, Daegu, 41566, South Korea ⓘ ⓘ 59552941200; 57221739597; 57221744477; 55660095600; 55450732800; 56962990300 ⓘ yhpark@kmu.ac.kr; parkyh@knu.ac.kr; ⓘ IEEE Transactions on Intelligent Transportation Systems ⓘ IEEE T INTELL TRANSP ⓘ 1524-9050 1558-0016 SCIE ENGINEERING, CIVIL;ENGINEERING, ELECTRICAL & ELECTRONIC;TRANSPORTATION SCIENCE & TECHNOLOGY ⓘ 2024 8.4 2.5 0 2025-06-11 ⓘ 0 ⓘ ⓘ Authentication; cryptanalysis; Internet of Vehicles (IoV); physical unclonable function (PUF); security; unmanned aerial vehicle (UAV) ⓘ Authentication; Target drones; Aerial vehicle; Authentication scheme; Cryptanalyze; Curve cryptography; Elliptic curve; Internet of vehicle; Physical unclonable function; Roadside units; Security; Unmanned aerial vehicle; Drones ⓘ English Article in press 2025 10.1109/tits.2025.3564581 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ BAPS-DITS: Blockchain-Enabled Accountable Privacy-Preserving Scheme for Decentralized Intelligent Transportation Systems ⓘ The integration of intelligent transportation systems (ITS) within the smart grid has significantly enhanced the reliability, efficiency, and security of vehicle-to-grid (V2G) services over the past decade, leading to increased research interest in this technology. Charging stations (CSs) utilize electric vehicles (EVs) to manage demand response and provide sustainable energy solutions. However, the transmission of information between EVs and CSs via public channels causes critical security vulnerabilities. Although much effort has been made to overcome the challenge of protecting security and privacy in V2G environments, these efforts have either been proposed based on a centralized architecture or do not ensure essential security requirements, such as self-sovereignty, reliable, and blockchain scalability. Furthermore, in decentralized network, it is difficult to provide reliable energy distribution because a malicious participant can easily try to inflate trading volumes and manipulate energy prices. In this paper, we propose a new blockchain-enabled, reliable, privacy-preserving scheme using decentralized identifiers (DIDs) for preventing energy wash trading in V2G networks called BAPS-DITS. BAPS-DITS guarantees to tackle the above challenges without a trusted third-party intervention. Additionally, we use informal and formal (mathematical) analysis to prove the security of BAPS-DITS and conduct a comparative analysis comparing the security properties, computational cost, and communication cost of BAPS-DITS to previous studies. Furthermore, we implement BAPS-DITS on a practical Ethereum network, demonstrating its efficiency and feasibility, showing that BAPS-DITS provides self-sovereignty, accountability, and blockchain scalability; thus, it is suitable for actual V2G environments. ⓘ Park, Kisung; Das, Ashok Kumar; Park, Youngho ⓘ Gachon Univ, Dept Comp Engn Smart Secur, Seongnam 13120, South Korea; Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea ⓘ Das, Ashok Kumar/U-2790-2019; Park, Kisung/KIG-3849-2024 ⓘ 57194833768; 55450732800; 56962990300 ⓘ kisung@gachon.ac.kr; iitkgp.akdas@gmail.com; parkyh@knu.ac.kr; ⓘ IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS ⓘ IEEE T INTELL TRANSP ⓘ 1524-9050 1558-0016 26 5 SCIE ENGINEERING, CIVIL;ENGINEERING, ELECTRICAL & ELECTRONIC;TRANSPORTATION SCIENCE & TECHNOLOGY ⓘ 2024 8.4 2.5 0 2025-05-07 ⓘ 0 0 Blockchains; Vehicle-to-grid; Security; Scalability; Reliability; Authentication; Privacy; Public key; Peer-to-peer computing; Electronic mail; Vehicle-to-grid (V2G); blockchain; security and privacy; authentication; self-sovereignty; wash trading ⓘ MUTUAL AUTHENTICATION PROTOCOL; SECURE; V2G; LIGHTWEIGHT; EFFICIENT; INTERNET ⓘ authentication; blockchain; security and privacy; self-sovereignty; Vehicle-to-grid (V2G); wash trading ⓘ Barium alloys; Blockchain; Cost benefit analysis; Differential privacy; Intelligent vehicle highway systems; Scalability; Block-chain; Charging station; Decentralised; Intelligent transportation systems; Privacy preserving; Security and privacy; Self-sovereignty; Vehicle to Grid (V2G); Vehicle-to-grid (V2G); Wash trading; Vehicle-to-grid ⓘ English 2025 2025-05 10.1109/tits.2025.3542795 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Body mass index and progesterone receptor in postmenopausal ER-positive/HER2-negative breast cancer: A nation-wide study in Korean breast cancer society and the multi-institutional cohort ⓘ Background: Obesity is a risk factor for breast cancer and associated with increased estrogen levels that stimulate the progesterone receptor (PgR). Understanding interplay between obesity, PgR, and prognosis in estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer (ER+/ HER2-) is crucial. This study aimed to investigate the association between body mass index (BMI) and the prognostic value of PgR. Methods: Study included 10,125 postmenopausal patients with ER+/HER2-breast cancer between January 1991 to December 2019. Patients were categorized according to BMI (cutoff: 25 kg/m(2)) and PgR (positive/negative). The primary outcomes were the 6-year overall survival (OS) in the Korean Breast Cancer Registry (KBCR) cohort and 6-year recurrence-free survival (RFS) in the multi-institutional cohort. Results: In both cohorts, a greater proportion of patients with high BMI were PgR-positive, and the mean BMI was higher in the PgR-positive group. PgR-negativity was associated with worse 6-year OS in the KBCR cohort among patients with BMI >= 25 kg/m(2) (hazard ratio [HR], 1.45; 95 % confidence intervals [CI], 1.06-1.97; P = .02), but not in those with BMI = 25 kg/m(2) (HR, 2.93; 95 % CI, 1.29-6.69; P = .01). The mean 21-gene recurrence score was higher in the PgR-negative group, regardless of the BMI. Conclusions: In postmenopausal patients with ER+/HER2-breast cancer, the prognostic impact of PgR is modified by BMI. PgR-negativity is a strong predictor of poor outcomes in obese patients but not in non-obese patients. ⓘ Lee, Janghee; Bae, Soong June; Kim, Hong Kyu; Nam, Seok Jin; Kim, Hee Jeong; Bae, Soo Youn; Park, Ho Yong; Ko, Byung Kyun; Park, Jung Ho; Kwon, Yeonjoo; Park, Youri; Baek, Seung Ho; Kook, Yoowon; Kim, Sanghwa; Lim, Young Ah; Kang, Hee-Joon; Kim, Doyil; Jeong, Joon; Ahn, Sung Gwe ⓘ Ewha Womans Univ, Coll Med, Dept Surg, Mokdong Hosp, Seoul, South Korea; Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg, Seoul, South Korea; Yonsei Univ, Coll Med, Inst Breast Canc Precis Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Surg, Seoul Natl Univ Hosp, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Surg, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Surg, Ulsan, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Surg, Chuncheon, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Dept Surg, Dongtan, South Korea; Gangnam Severance Hosp, Dept Surg, 712 Eonjuro, Seoul 06273, South Korea ⓘ ⓘ 56768641200; 57213747370; 57199392663; 59914130300; 57205135299; 57202757220; 59613158700; 59913927700; 57208899327; 59307308700; 59913539700; 57208625357; 59913342100; 57190119079; 57188933788; 59439223900; 56709015900; 55184774900; 59693417100 ⓘ asg2004@yuhs.ac; ⓘ BREAST ⓘ BREAST ⓘ 0960-9776 1532-3080 82 SCIE OBSTETRICS & GYNECOLOGY;ONCOLOGY ⓘ 2024 7.9 2.5 N/A ⓘ 0 0 ⓘ ESTROGEN-RECEPTOR; PROGNOSTIC-SIGNIFICANCE; HORMONE; OBESITY; EXPRESSION; ADIPOSITY; WOMEN; MECHANISMS; ESTRADIOL; TAMOXIFEN ⓘ ⓘ epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; adult; aged; Article; body mass; breast-conserving surgery; cancer prognosis; cancer recurrence; cancer risk; cancer surgery; cancer survival; cohort analysis; confidence interval; estrogen receptor-positive, HER2-negative breast cancer; female; hazard ratio; human; Korean (people); major clinical study; obesity; observational study; overall survival; patient registry; postmenopause; recurrence free survival; retrospective study; risk factor ⓘ English 2025 2025-08 10.1016/j.breast.2025.104515 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Critical Role of Non-Fullerene Crystalline Domains in Stabilizing Charge Separation in Bulk Heterojunction Organic Solar Cells ⓘ This study addresses the role of energetic offsets resulting from non-fullerene acceptor crystallization/aggregation in stabilizing charge separation in organic bulk heterojunction (BHJ) solar cells. Devices are fabricated using PM6 as electron donor and either IDIC or Y6 as acceptor, with blend ratios from 5:1 to 1:1. Reducing acceptor content significantly lowers device performance, most notably for initially higher performing PM6:Y6 BHJ's (from 14.31% to 0.95%) compared to PM6:IDIC (from 11.28% to 3.40%). Optical, optoelectronic, and morphological characterizations reveal that lower acceptor content PM6:Y6 devices exhibit suppressed acceptor aggregation/crystallinity, correlated with increased recombination losses and lower efficiency. Charge separation in optimal (1:1) PM6:Y6 devices is found to be stabilized by a LUMO level energetic offset between intermixed and pure, more crystalline, Y6 domains, driven by strong electronic interactions between Y6 molecules. In contrast, PM6:IDIC devices show minimal changes in energetics and recombination kinetics, aligning with their smaller performance decline, and consistent with IDIC's weaker electronic interactions. As such strong electronic interactions between Y6 molecules are concluded to provide an energetic stabilization of electrons in more aggregated/crystalline Y6 domains, suppressing charge recombination, and analogous to that observed for the highest performing fullerene acceptor PCBM. © 2025 The Author(s). Advanced Energy Materials published by Wiley-VCH GmbH. ⓘ Jeong, Soyeong; Rana, Aniket; Xu, Weidong; Ai, Keren; Kilbride, Rachel Catherine; Wang, Yiwen; Lee, Damin; Tuladhar, Pabitra Shakya; Cha, Hyojung; Durrant, James Robert ⓘ Department of Chemistry and Centre for Processable Electronics, Imperial College London, White City Campus, London, W12 0BZ, United Kingdom; Department of Chemistry and Centre for Processable Electronics, Imperial College London, White City Campus, London, W12 0BZ, United Kingdom, Department of Engineering, Durham University, Durham, DH13LE, United Kingdom; Department of Chemical Engineering and Biotechnology, Office 1-03, Philippa Fawcett Drive, Cambridge, CB3 0AS, United Kingdom; Department of Chemistry and Centre for Processable Electronics, Imperial College London, White City Campus, London, W12 0BZ, United Kingdom; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, United Kingdom; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom; School of Energy Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry and Centre for Processable Electronics, Imperial College London, White City Campus, London, W12 0BZ, United Kingdom; School of Energy Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry and Centre for Processable Electronics, Imperial College London, White City Campus, London, W12 0BZ, United Kingdom, SPECIFIC, Faculty of Science and Engineering, Swansea University, Swansea, SA1 8EN, United Kingdom ⓘ ⓘ 56562251600; 56608766900; 57222284706; 59303296700; 57208482239; 57196393719; 56495672200; 55315437700; 35885242200; 56401622800 ⓘ j.durrant@imperial.ac.uk; hcha@knu.ac.kr; ⓘ Advanced Energy Materials ⓘ ADV ENERGY MATER ⓘ 1614-6832 1614-6840 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2024 26 2.5 ⓘ 0 ⓘ ⓘ bulk heterojunction; charge transfer; intermixed phases; non-fullerene acceptors; photovoltaic device; recombination dynamics; solar cells ⓘ Blending; Crystalline materials; Heterojunctions; Molecules; Morphology; Nanostructured materials; Solar cells; Solar power generation; Bulk heterojunction; Bulk heterojunction organic solar cells; Charge-separation; Crystalline domains; Electronic interactions; Intermixed phase; Non-fullerene acceptor; Organic bulk-heterojunction solar cells; Photovoltaic devices; Recombination dynamics; Charge transfer ⓘ English Article in press 2025 10.1002/aenm.202501633 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Enzyme cascades for high-yield conversion of D-xylose into D-ribose by overcoming equilibrium constraints and enhancing selectivity ⓘ D-Ribose is essential for critical cellular functions and the synthesis of antiviral nucleosides. However, traditional chemical synthesis and fermentation methods of D-ribose production suffer from low yields and inefficient resource utilization. Here, we present a highly efficient enzymatic cascade strategy that utilizes selective phosphorylation and dephosphorylation processes, coupled with ATP regeneration to convert D-xylose into Dribose with high yield. By optimizing this enzyme cascade, we achieved a substantial increase in D-ribose yield from 23.4 % to 93.5 % mol/mol, effectively overcoming the equilibrium limitations of sugar conversion processes. Notably, our approach allows for the selective conversion of D-xylose to D-ribose in lignocellulosic hydrolysates, even in the presence of D-glucose. This work demonstrates the highly efficient enzymatic conversion of D-xylose into D-ribose offering a competitive alternative to existing chemical synthesis methods. Our findings provide a novel approach to cellulosic biomass valorization and represent a significant contribution to the field of biorefinery. ⓘ Lee, Ja Hyun; Kim, Doyeon; Kim, Yoonjoo; Kim, Dong Hyun; Park, Yong-Cheol; Kim, Kyoung Heon ⓘ Korea Univ, Grad Sch, Dept Biotechnol, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Seoul 02707, South Korea ⓘ Kim, Dong Hyun/LDT-2672-2024 ⓘ 59723482300; 55742876000; 59723482400; 55574224522; 56128579600; 34770896300 ⓘ dhkim85@knu.ac.kr; ycpark@kookmin.ac.kr; khekim@korea.ac.kr; ⓘ BIORESOURCE TECHNOLOGY ⓘ BIORESOURCE TECHNOL ⓘ 0960-8524 1873-2976 428 SCIE AGRICULTURAL ENGINEERING;ENERGY & FUELS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY ⓘ 2024 9 2.5 0 2025-05-07 ⓘ 1 1 D -Ribose; Enzyme cascade; D -Xylose; Biomass valorization ⓘ ESCHERICHIA-COLI; D-PSICOSE; EFFICIENT BIOSYNTHESIS; BACILLUS-SUBTILIS; ISOMERASE; SUGARS; THERMODYNAMICS; BIOCATALYSIS; PHOSPHATASES; SUPERFAMILY ⓘ Biomass valorization; D-Ribose; D-Xylose; Enzyme cascade ⓘ Adenosine Triphosphate; Biomass; Glucose; Hydrolysis; Lignin; Phosphorylation; Ribose; Xylose; adenosine triphosphate; ribose; xylose; glucose; lignin; Antiviral nucleoside; Biomass valorizations; Cellular function; D ribose; D-Xylose; Enzyme cascades; Equilibrium constraint; Higher yield; Low-yield; Resources utilizations; biomass; cell component; crop improvement; enzyme activity; fermentation; sugar; valorization; Article; biomass valorization; enzyme activity; equilibrium constant; phosphorylation and dephosphorylation; biomass; biosynthesis; hydrolysis; metabolism; phosphorylation ⓘ English 2025 2025-07 10.1016/j.biortech.2025.132435 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Explainable Deep Learning-Enabled Malware Attack Detection for IoT-Enabled Intelligent Transportation Systems ⓘ The Internet of Things (IoT) has the potential to improve the complementary of communication, control, and information processing within the public transportation system. The IoT-enabled Intelligent Transportation System (ITS) ensures that automated transportation is networked and operated collaboratively. The IoT-enabled ITS has revolutionized the transportation industry by enabling the seamless integration of a wide range of devices and systems. It makes the strategic use of networked devices, sensors, and data analytics to improve transportation network efficiency, safety, and environmental friendliness. The usage of the IoT in the ITS has grown in popularity due to its capacity to improve traffic control, reduce congestion, facilitate live monitoring, and optimize transportation operations. The IoT-enabled ITS systems and devices must be protected from cyber-attacks for various reasons, including preserving sensitive data, guaranteeing privacy, preventing unauthorized access, and protecting against the risk of interruptions or manipulations. Malware attacks affect the working and performance of the deployed smart IoT devices. We propose a secure deep learning-enabled malware attack detection for IoT-enabled ITS (in short, SDLMA-IITS). The approach of explainable artificial intelligence (XAI) has been utilized for the effective detection of malware. A deep security analysis of the proposed SDLMA-IITS is presented to prove its security against various potential attacks. The comparative performance analysis of SDLMA-IITS is given with the other similar existing schemes. Finally, a practical implementation of SDLMA-IITS is provided to measure its impact on the security of the IoT-enabled ITS systems and devices. ⓘ Wazid, Mohammad; Singh, Jaskaran; Pandey, Charvi; Sherratt, R. Simon; Das, Ashok Kumar; Giri, Debasis; Park, Youngho ⓘ Graph Era Deemed Univ, Dept Comp Sci & Engn, Dehra Dun 248002, India; Univ Nottingham, Sch Comp Sci, Nottingham NG7 2QL, England; Univ Reading, Dept Biomed Engn, Reading RG6 6AY, England; Int Inst Informat Technol Hyderabad, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Korea Univ, Coll Informat, Dept Comp Sci & Engn, Seoul 02841, South Korea; Maulana Abul Kalam Azad Univ Technol West Bengal, Dept Informat Technol, Haringhata 741249, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea ⓘ wazid, mohammad/X-4211-2018; Singh, Jaskaran/AGX-6621-2022; Das, Ashok/ADT-4705-2022; Giri, Debasis/ABF-6428-2022; WAZID, MOHAMMAD/X-4211-2018 ⓘ 55480987400; 57213875744; 59523411300; 7004090619; 55450732800; 23396481600; 56962990300 ⓘ wazidkec2005@gmail.com; jaskaran.jsk2001@gmail.com; charvipandey3@gmail.com; r.s.sherratt@reading.ac.uk; iitkgp.akdas@gmail.com; debasis_giri@hotmail.com; parkyh@knu.ac.kr; ⓘ IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS ⓘ IEEE T INTELL TRANSP ⓘ 1524-9050 1558-0016 26 5 SCIE ENGINEERING, CIVIL;ENGINEERING, ELECTRICAL & ELECTRONIC;TRANSPORTATION SCIENCE & TECHNOLOGY ⓘ 2024 8.4 2.5 3.08 2025-05-07 ⓘ 4 4 Security; Malware; Internet of Things; Testing; Explainable AI; Electronic mail; Accuracy; Performance evaluation; Deep learning; Public transportation; Intelligent transportation system (ITS); Internet of Things (IoT); explainable artificial intelligence (XAI); malware attacks; cybersecurity; deep learning ⓘ INTRUSION DETECTION SYSTEM; SECURITY; PRIVACY; CHALLENGES; INTERNET; FRAMEWORK; ISSUES ⓘ cybersecurity; deep learning; explainable artificial intelligence (XAI); Intelligent transportation system (ITS); Internet of Things (IoT); malware attacks ⓘ Computer viruses; Cyber attacks; Data privacy; Network security; Attack detection; Communication control; Cyber security; Deep learning; Explainable artificial intelligence (XAI); Intelligent transportation system; Intelligent transportation systems; Internet of thing; Malware attacks; Public transportation systems; Traffic congestion ⓘ English 2025 2025-05 10.1109/tits.2025.3525505 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Global perspectives on advancing photovoltaic system performance-A state-of-the-art review ⓘ Due to their rapid commercialisation, Photovoltaic (PV) systems are considered the foundation of present and future renewable energy. Nonetheless, the full potential of this technology has yet to be realised because of several challenges. Consequently, effective solutions are critical for achieving high solar PV performance. This work aims to consolidate and provide a unique global review of pioneering recent studies on the most influential factors affecting solar PV performance. Four driven parameters are emphasised: dust/soil, tilt angle, temperature, and humidity. Regional, national and international experiments performed indoor, outdoor and at the laboratory, real-scale studies and numerical simulation dealing with PV performance challenges and potential routes for improvement and optimisation are reported. The review included studies from across the world, including the Middle East, Africa, the Asia Pacific, America and Europe. The figures and detailed tables with pertinent information on the key subject are provided. The studies suggest that the dust can reduce PV efficiency by up to 24 %. Adjusting PV module alignment up to five times a year can enhance energy yield by 3.63 %. The efficiency drops by 0.05 %/degrees C, with the temperature increase from 25 degrees C to 45 degrees C causing an efficiency drop of up to 20.22 %. This paper provides a comprehensive analysis of the thermal management, economic implications, environmental impact, and disposal concerns associated with end-of-life PV modules, highlighting the need for effective regulations to address emerging challenges. Finally, this work can be used as a pertinent guide for communities working in the field of solar PV involving researchers, industrialists and policymakers in the design, sizing, application and commercialisation of high-performance PV technologies and systems. ⓘ Rehman, Tauseef-ur; Qaisrani, Mumtaz A.; Shafiq, M. Basit; Baba, Yousra Filali; Aslfattahi, Navid; Shahsavar, Amin; Cheema, Taqi Ahmad; Park, Cheol Woo ⓘ Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Khwaja Fareed Univ Engn & Informat Technol, Dept Mech Engn, Rahim Yar Khan 64200, Pakistan; Natl Univ Sci & Technol, Dept Mech Engn, Islamabad 44000, Pakistan; Mohammed V Univ, Ecole Natl Super Arts Metiers ENSAM R, Energy Res Ctr, Dept Energy & Environm, BP 6207, Rabat, Morocco; Czech Tech Univ, Fac Mech Engn, Dept Fluid Mech & Thermodynam, Techn 4, Prague 16607, Czech Republic; Kermanshah Univ Technol, Dept Mech Engn, Kermanshah, Iran; Ghulam Ishaq Khan Inst Engn Sci & Technol, Fac Mech Engn, Topi 23460, Pakistan ⓘ Aslfattahi, Navid/AAL-6040-2020; Rehman, Tauseef-ur/AAE-3086-2022; Qaisrani, Mumtaz/AFL-8780-2022 ⓘ 57159403400; 57200525532; 57546427100; 57194346885; 57210147607; 36523886500; 36522492600; 7408416474 ⓘ tacheema@giki.edu.pk; chwoopark@knu.ac.kr; ⓘ RENEWABLE & SUSTAINABLE ENERGY REVIEWS ⓘ RENEW SUST ENERG REV ⓘ 1364-0321 1879-0690 207 SCIE ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY ⓘ 2024 16.3 2.5 7.85 2025-05-07 ⓘ 12 15 Dust/soil; Humidity; Performance evaluation; Photovoltaics; Tilt angle; Temperature ⓘ OPTIMUM TILT ANGLES; PV-POWER-PLANT; SOLAR PV; DUST DEPOSITION; ELECTRICAL PERFORMANCE; AMBIENT-TEMPERATURE; THERMAL MANAGEMENT; RELATIVE-HUMIDITY; ENERGY-PRODUCTION; RENEWABLE ENERGY ⓘ Dust/soil; Humidity; Performance evaluation; Photovoltaics; Temperature; Tilt angle ⓘ Carbon capture and utilization; Commercialisation; Dust/soil; Global perspective; Performances evaluation; Photovoltaic modules; Photovoltaic performance; Photovoltaic systems; Photovoltaics; Solar photovoltaics; Tilt angle; Critical temperature ⓘ English 2025 2025-01 10.1016/j.rser.2024.114889 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Mineralogical and geochemical signatures of zircons recording magmatic to hydrothermal processes in the Li-pegmatite system at the Boam deposit, South Korea ⓘ In this study, we conduct a micro-analysis of zircons from the Li-bearing Boam pegmatite deposit in Uljin, South Korea, with the aim of understanding the specific evolution process of the pegmatitic melt. All of the zircons observed in the pegmatite have identical textural features (T1, T2, and T3) and distributions of major/minor elements. The primary domain T1 is identified by a relatively bright ring or band within oscillatory and sector zoning in backscattered electron and cathodoluminescence images. The concentrations of UO2 and HfO2 reach 0.81 wt% and 12.88 wt%, respectively. These results indicate that the zircons are derived from highly evolved melts of magmatic origin. However, the chondrite-normalized rare earth element (REE) patterns categorize these zircons into type-A and type-B groups. This distinction can be explained by a model in which each type of zircon grows from separate melts. In type-A zircons, T1 has positive Ce anomalies and a steeply increasing REE pattern from light REEs (LREEs) to heavy REEs (HREEs), suggesting crystallization from a silicic melt with a high silicate content and a relatively low H2O content. On the other hand, type-B zircons have a negative Ce anomaly at T1, with a flat REE pattern due to slight LREE enrichment, indicating crystallization from an aqueous melt with a low silicate content and a high H2O content. T2 is recognized as a relatively pure zircon composition with a secondary texture that recrystallized after T1 crystallization. The embayment/inward-penetrating textures and mineral inclusions related to the mineral assemblage in the pegmatite means T2 has the signature of hydro- thermal alteration via F-rich fluid exsolved from these melts. This domain formed via a coupled dissolution-reprecipitation process that selectively recrystallized the primary domains with a very high U and Th content. This domain exhibits a higher LREE content compared to T1 in both types of zircon, suggesting that the hydrothermal fluid is enriched in the LREEs due to their incompatible characteristics and the selective retention of REEs due to their similar ionic radii. T3 displays a mottled/porous texture and the enrichment of non-formula elements such as Ca, Fe, and Al, indicating that this domain has undergone a typical diffusion-reaction process due to metamictization. Considering the time required for the accumulation of radiation damage, this domain is not believed to have formed during the pegmatite crystallization stage but rather to have formed via the infiltration of fluids of external origin after geological-scale time. Overall, the crystallization and subsequent alteration of these zircons serve as an indicator of the overall evolutionary history of the pegmatite. Our findings specifically suggest that the zircons in the Boam deposit have been crystallized in a melt-melt immiscibility process involving a silicic melt and an aqueous melt and subsequently recrystallized by a hydrothermal fluid exsolved from the immiscible melts. ⓘ Lee, Youseong; Choi, Woohyun; Jeong, Youn-Joong; Park, Changyun ⓘ Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Korea Basic Sci Inst, Ochang Ctr, Cheongju 28119, South Korea ⓘ ⓘ 58535828100; 57195467789; 49161097900; 56197393100 ⓘ changyun.park@knu.ac.kr; ⓘ ORE GEOLOGY REVIEWS ⓘ ORE GEOL REV ⓘ 0169-1368 1872-7360 176 SCIE GEOLOGY;MINERALOGY;MINING & MINERAL PROCESSING ⓘ 2024 3.6 2.5 0 2025-05-07 ⓘ 0 0 Zircon; Li-pegmatite; Immiscibility; Alteration; Rare earth element ⓘ RARE-EARTH-ELEMENTS; LA-ICP-MS; TRACE-ELEMENT; GRANITIC PEGMATITES; RADIATION-DAMAGE; OXIDATION-STATE; SILICATE MELTS; COMPLETE MISCIBILITY; CHINA IMPLICATIONS; QINLING OROGEN ⓘ Alteration; Immiscibility; Li-pegmatite; Rare earth element; Zircon ⓘ North Kyongsang; South Korea; Uljin; Carbon; Cerium oxide; Descaling; Exploratory geochemistry; Faulting; Gold deposits; Hydrogen; Inert gases; Iron ores; Lithium alloys; Lithium deposits; Manganese nodules; Membrane fouling; Mica; Ore sinter; Oxygen; Phosphorus; Quartz; Radioisotopes; Recrystallization (metallurgy); Selenium; Sulfur; Zircon deposits; Alteration; Evolution process; Geochemical signatures; Hydrothermal fluids; Hydrothermal process; Li-pegmatite; Micro analysis; Pegmatite deposits; Rare-earths; South Korea; cathodoluminescence; geochemistry; hydrothermal activity; immiscibility; lithium; mineralogy; pegmatite; rare earth element; zircon; Clay alteration ⓘ English 2025 2025-01 10.1016/j.oregeorev.2024.106403 ⓘ 바로가기 바로가기 바로가기 바로가기
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