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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Structurally engineered vitamin B12 on graphene as a bioinspired metal-N-C-based electrocatalyst for effective overall water splitting in alkaline media | The development of a cost-effective, high-performance, and stable electrocatalyst capable of producing clean and renewable hydrogen via water splitting is challenging. This study demonstrates a remarkable electrocatalytic water-splitting activity in alkaline media by employing a bioinspired, noble-metal-free vitamin B12 (VB12) catalyst on a conductive graphene substrate. VB12 could inherently produce unique Co-N-4 active sites upon thermal treatment owing to its Co-centered macrocyclic corrin ring, and VB12 was further engineered to produce additional Fe-N-x sites through the incorporation of Fe as a secondary metal cation. The optimal Fe content in VB12 resulted in a high density of exposed Co-N-4 and Fe-N-x active sites. Consequently, the optimized catalyst, denoted as Fe-VB12-2@GR, demonstrated outstanding bifunctional electrocatalytic performance, with overpotentials of only 120 and 300 mV at 10 mA cm(-2) for the hydrogen and oxygen evolution reactions, respectively, while maintaining high stability and durability over a period of 20 h. The cell voltage required for water splitting was calculated as similar to 1.65 V at 10 mA cm(-2). This work demonstrates a state-of-the-art design of a bioinspired catalyst for water electrolysis, and thus, we believe that this work has the potential to bring considerable advancements in clean and renewable energy technologies. | Lee, Dong-Eun; Moru, Satyanarayana; Jo, Wan-Kuen; Tonda, Surendar | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kakatiya Inst Technol & Sci, Dept Phys Sci, Warangal 506015, Telangana, India | Tonda, Surendar/AAO-3358-2020; Jo, Wan/AAO-5329-2020; MORU, SATYANARAYANA/AAF-3189-2021 | 56605563300; 58562229700; 7103322277; 56114866900 | wkjo@knu.ac.kr;surendart@knu.ac.kr; | APPLIED SURFACE SCIENCE | APPL SURF SCI | 0169-4332 | 1873-5584 | 575 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, COATINGS & FILMS;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 6.7 | 2.4 | 1.18 | 2025-06-25 | 12 | 14 | Bioinspired; Vitamin B12; Bimetallic catalyst; Electrocatalysis; Overall water splitting | OXYGEN REDUCTION REACTION; HYDROGEN-PRODUCTION; HIGHLY EFFICIENT; BIFUNCTIONAL ELECTROCATALYSTS; CARBON NITRIDE; ACTIVE-SITES; FUEL-CELLS; EVOLUTION; CATALYSTS; OXIDE | Bimetallic catalyst; Bioinspired; Electrocatalysis; Overall water splitting; Vitamin B12 | Cost effectiveness; Electrocatalysts; Graphene; Iron; Precious metals; Renewable energy resources; Active site; Alkaline media; Bimetallic catalysts; Bioinspired; Cost effective; Overall water splitting; Performance; Vitamin B12; Water splitting; ]+ catalyst; Electrocatalysis | English | 2022 | 2022-02-01 | 10.1016/j.apsusc.2021.151729 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis of VOC-sensing Dyes for Fabrication of Cotton-based Chromogenic Sensors | Three vapochromic dyes named DiMo, MoMe, DiMe with different substituents were synthesized and investigated on their color change properties after exposure to 32 organic solvents after dyeing on cotton fabrics. The cotton-based sensor exhibited strong sensing properties to polar solvents rather than non-polar solvents. Especially, N,N-dimethylformamide detection was the best showing a color difference of 12.8 for DiMo, 21.4 for MoMe, and 25.8 for DiMe under 300 ppm exposure. Even at as low concentration as 10 ppm of N,N-dimethylformamide, the color change values were reached 7.3, 10.6, and 13.6 within an hour. The maximum absorption wavelength of the cotton-based sensor was shifted from 580 to 560, 570 to 560, and 560 to 540 nm, respectively, by the N,N-dimethylformamide exposure. The sensing mechanism was considered to depend on solvatochromism, aggregational properties of the dyes and adsorption amount of volatile organic compounds on textile substrates on which the dyes were applied. Finally, the reusability of the cotton-based sensor was tested for 10 cycles. | Lee, Junheon; Park, Namju; Kim, Taekyeong | Kyungpook Natl Univ, Dept Text Syst Engn, Coll Engn, Daegu, South Korea | 57195904688; 57810869700; 24587275700 | taekyeong@knu.ac.kr; | CELLULOSE | CELLULOSE | 0969-0239 | 1572-882X | 29 | 16 | SCIE | MATERIALS SCIENCE, PAPER & WOOD;MATERIALS SCIENCE, TEXTILES;POLYMER SCIENCE | 2022 | 5.7 | 2.4 | 0.44 | 2025-06-25 | 5 | 5 | Vapochromism; Solvatochromism; Volatile Organic Compounds; Cotton; Sensors; Dyes | CHEMOSENSORS; DERIVATIVES; COMPLEXES; EXPOSURE; COLOR; ACID | Cotton; Dyes; Sensors; Solvatochromism; Vapochromism; Volatile Organic Compounds | Colorimetry; Cotton; Dyes; Exposure; Solvents; Voc; Color; Colorimetry; Cotton; Dimethylformamide; Reusability; Solvents; Chromogenic sensors; Color changes; N-N-dimethylformamide; Polar solvents; Property; Sensing dye; Sensing property; Solvatochromisms; Synthesised; Vapochromism; Volatile organic compounds | English | 2022 | 2022-11 | 10.1007/s10570-022-04775-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Target ischemic stroke model creation method using photoacoustic microscopy with simultaneous vessel monitoring and dynamic photothrombosis induction | The ischemic stroke animal model evaluates the efficacy of reperfusion and neuroprotective strategies for ischemic injuries. Various conventional methods have been reported to induce the ischemic models; however, controlling specific neurological deficits, mortality rates, and the extent of the infarction is difficult as the size of the affected region is not precisely controlled. In this paper, we report a single laser-based localized target ischemic stroke model development method by simultaneous vessel monitoring and photothrombosis induction using photoacoustic microscopy (PAM), which has minimized the infarct size at precise location with high reproducibility. The proposed method has significantly reduced the infarcted region by illuminating the precise localization. The reproducibility and validity of suggested method have been demonstrated through repeated experiments and histological analyses. These results demonstrate that our method can provide the ischemic stroke model closest to the clinical pathology for brain ischemia research from inducement, occurrence mech-anisms to the recovery process. | Seong, Daewoon; Yi, Soojin; Han, Sangyeob; Lee, Jaeyul; Park, Sungjo; Hwang, Yang-Ha; Kim, Jeehyun; Kim, Hong Kyun; Jeon, Mansik | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Inst Biomed Engn, Sch Med, Daegu 41566, South Korea; Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA; Pohang Univ Sci & Technol, Pohang Innotown Ctr, Pohang 37673, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu 41944, South Korea | ; HWANG, Yang-Ha/F-3068-2013; Lee, Junsoo/IUO-9627-2023 | 57212512353; 56783537100; 57193695305; 57188689420; 7501826338; 7402311308; 7601373350; 57218260940; 24171094000 | okeye@knu.ac.kr;msjeon@knu.ac.kr; | PHOTOACOUSTICS | PHOTOACOUSTICS | 2213-5979 | 27 | SCIE | ENGINEERING, BIOMEDICAL;INSTRUMENTS & INSTRUMENTATION;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 7.9 | 2.4 | 1.2 | 2025-06-25 | 10 | 10 | Localized target ischemic stroke model; Photoacoustic microscopy; Target blood vessel monitoring; Dynamic photothrombosis induction; Minimal invasive model | FOCAL CEREBRAL-ISCHEMIA; COMPUTED-TOMOGRAPHY; ARTERY OCCLUSION; INTRALUMINAL SUTURE; RAT; MICE; INFARCTION; RADIATION; CHILDREN; PROTEIN | Dynamic photothrombosis induction; Localized target ischemic stroke model; Minimal invasive model; Photoacoustic microscopy; Target blood vessel monitoring | Clinical research; Photoacoustic microscopy; Animal model; Dynamic photothrombose induction; Ischemic strokes; Localised; Localized target ischemic stroke model; Minimal invasive; Minimal invasive model; Model creation; Reperfusion; Target blood vessel monitoring; Blood vessels | English | 2022 | 2022-09 | 10.1016/j.pacs.2022.100376 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Authenticated Key Agreement Scheme With User Anonymity and Untraceability for 5G-Enabled Softwarized Industrial Cyber-Physical Systems | With the tremendous growth of Information and Communications Technology (ICT), Cyber Physical Systems (CPS) have opened the door for many potential applications ranging from smart grids and smart cities to transportation, retail, public safety and networking, healthcare and industrial manufacturing. However, due to communication via public channel occurring among various entities in an industrial CPS (ICPS) with the help of the 5G technology and Software-Defined Networking (SDN), it poses several potential security threats and attacks. To mitigate these issues, we propose a new three-factor user authentication and key agreement scheme (UAKA-5GSICPS) for 5G-enabled SDN based ICPS environment. UAKA-5GSICPS allows an authorized user to access the real-time data directly from some designated Internet of Things (IoT)-based smart devices provided that a successful mutual authentication among them is executed via their controller node in the SDN network. It is shown to be robust against various potential attacks through detailed security analysis including the simulation-based formal security verification. A detailed comparative study with the help of experimental results shows that UAKA-5GSICPS achieves better trade-off among security and functionality features, communication and computation overheads as compared to other existing competing schemes. | Sutrala, Anil Kumar; Obaidat, Mohammad S.; Saha, Sourav; Das, Ashok Kumar; Alazab, Mamoun; Park, Youngho | CA Technol, Enterprise Secur Div ESD, Hyderabad 500032, India; Univ Sharjah, Coll Comp & Informat, Sharjah 27272, U Arab Emirates; Univ Jordan, King Abdullah II Sch Informat Technol, Amman 11942, Jordan; Univ Sci & Technol Beijing, Sch Commun & Comp Engn, Beijing 100083, Peoples R China; Int Inst Informat Technol IIIT, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Harks Darwin Univ, Coll Engn IT & Environm, Casuarina, NT 0810, Australia; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Obaidat, Life Fellow of IEEE, Mohammad/KBC-2747-2024; Alazab, Mamoun/AAG-6684-2021; Das, Ashok Kumar/U-2790-2019; Saha, Sourav/LSL-9012-2024 | 57148305900; 7005628795; 57207760870; 55450732800; 36661792200; 56962990300 | anilkurnarsutrala@gmail.com;msobaidat@gmail.com;sourav.saha@research.iiit.ac.in;iitkgp.akdas@gmail.com;ashok.das@iiit.ac.in;parkyh@lmu.ac.kr;alazab.m@ieee.org;parkyh@knu.ac.kr; | IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS | IEEE T INTELL TRANSP | 1524-9050 | 1558-0016 | 23 | 3 | SCIE | ENGINEERING, CIVIL;ENGINEERING, ELECTRICAL & ELECTRONIC;TRANSPORTATION SCIENCE & TECHNOLOGY | 2022 | 8.5 | 2.5 | 6.45 | 2025-06-25 | 84 | 82 | Security; Authentication; 5G mobile communication; Protocols; Switches; Smart devices; Virtualization; Industrial cyber physical systems (ICPS); softwarized networking; user authentication; security; MIRACL experiments; AVISPA simulation | SECURITY CHALLENGES; DEFINED NETWORKING | AVISPA simulation; Industrial cyber physical systems (ICPS); MIRACL experiments; security; softwarized networking; user authentication | Accident prevention; Authentication; Cyber Physical System; Economic and social effects; Embedded systems; Internet of things; Network security; Security systems; Authenticated key agreement; Computation overheads; Cyber-physical systems (CPS); Industrial manufacturing; Information and communications technology; Internet of Things (IOT); Mutual authentication; Software defined networking (SDN); 5G mobile communication systems | English | 2022 | 2022-03 | 10.1109/tits.2021.3056704 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Autocatalytic Surface Reduction-Assisted Synthesis of PtW Ultrathin Alloy Nanowires for Highly Efficient Hydrogen Evolution Reaction | Alloying noble metal catalysts with early transition metals (ETMs) has shown great promise by simultaneously boosting catalytic activity and durability because of their strong electronic interactions. However, the very negative reduction potential of ETMs has posed great challenges for the synthesis of the desired alloy catalysts, not to mention the structure-controlled synthesis. Here an autocatalytic surface reduction-assisted strategy is reported to realize the controllable synthesis of ultrathin PtW alloy nanowires (NWs). The experimental evidence and density functional theory (DFT) calculations demonstrate that the preformed Pt NWs in the synthesis serve as the catalyst to facilitate the reduction of W-x(+) species through the autocatalytic surface reduction mechanism. Using the alkaline hydrogen evolution reaction (HER) as a model reaction, the as-synthesized PtW NWs/C catalyst shows an ultralow overpotential of 18 mV at 10 mA cm(-2) and a high mass activity of 6.13 A mg(Pt)(-1) at an overpotential of 100 mV, ranking it among the most active catalysts. The dual roles of alloyed W atoms are further uncovered by theoretical simulations, involving the ensemble effect for accelerating H2O dissociation and a ligand effect for optimizing the hydrogen adsorption strength. | Gao, Lei; Yang, Zhilong; Sun, Tulai; Tan, Xin; Lai, Wenchuan; Li, Mengfan; Kim, Jeonghyeon; Lu, Yang-Fan; Choi, Sang-Il; Zhang, Wenhua; Ma, Chao; Smith, Sean C.; Zhou, Yi-Ge; Huang, Hongwen | Hunan Univ, Coll Chem & Chem Engn, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China; Zhejiang Univ Technol, Ctr Electron Microscopy, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China; Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China; Australian Natl Univ, Integrated Mat Design Lab, Dept Appl Math, Res Sch Phys, Canberra, ACT 2601, Australia; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Zhejiang Univ, State Key Lab Silicon Mat, Sch Mat Sci & Engn, Hangzhou 310027, Peoples R China; Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Natl Synchrotron Radiat Lab, Dept Chem Phys, Hefei 230026, Anhui, Peoples R China | Gao, Lei/KFQ-7375-2024; Huang, Hongwen/AAD-6853-2020; Smith, Sean/H-5003-2015; zhu, xinyu/KHY-9572-2024; Choi, Sang-Il/AGR-1133-2022; Ma, Chao/J-4569-2015; Tan, Xin/HJA-4548-2022; Zhang, Wenhua/B-3146-2010; Sun, Tulai/AAL-6164-2020 | 57190169111; 57295267400; 55747671500; 57198744869; 57189461547; 57211326783; 57194560892; 55697711600; 56167600800; 41562454300; 57214756963; 7406649493; 39962993800; 55738280200 | yigezhou@hnu.edu.cn;huanghw@hnu.edu.cn; | ADVANCED ENERGY MATERIALS | ADV ENERGY MATER | 1614-6832 | 1614-6840 | 12 | 11 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 27.8 | 2.5 | 3.27 | 2025-06-25 | 59 | 56 | autocatalytic reduction-assisted synthesis; dual roles; early transition metals; hydrogen evolution reaction; ultrathin PtW nanowires | OXYGEN; PLATINUM; ELECTROCATALYSTS; NANOPARTICLES; CATALYSTS; GROWTH; OXIDE | autocatalytic reduction-assisted synthesis; dual roles; early transition metals; hydrogen evolution reaction; ultrathin PtW nanowires | Density functional theory; Gas adsorption; Hydrogen; Nanowires; Precious metals; Alloy nanowires; Autocatalytic; Early-transition metals; Electronic interactions; Hydrogen evolution reactions; Noble metal catalysts; Overpotential; Surface reduction; Ultra-thin; ]+ catalyst; Catalyst activity | English | 2022 | 2022-03 | 10.1002/aenm.202103943 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efferent and afferent connections of supratrigeminal neurons conveying orofacial muscle proprioception in rats | The supratrigeminal nucleus (Su5) is a key structure for controlling jaw movements; it receives proprioceptive sensation from jaw-closing muscle spindles (JCMSs) and sends projections to the trigeminal motor nucleus (Mo5). However, the central projections and regulation of JCMS proprioceptive sensation are not yet fully understood. Therefore, we aimed to reveal the efferent and afferent connections of the Su5 using neuronal tract tracings. Anterograde tracer injections into the Su5 revealed that the Su5 sends contralateral projections (or bilateral projections with a contralateral predominance) to the Su5, basilar pontine nuclei, pontine reticular nucleus, deep mesencephalic nucleus, superior colliculus, caudo-ventromedial edge of the ventral posteromedial thalamic nucleus, parafascicular thalamic nucleus, zona incerta, and lateral hypothalamus, and ipsilateral projections (or bilateral projections with an ipsilateral predominance) to the intertrigeminal region, trigeminal oral subnucleus, dorsal medullary reticular formation, and hypoglossal nucleus as well as the Mo5. Retrograde tracer injections into the Su5 demonstrated that the Su5 receives bilateral projections with a contralateral predominance (or contralateral projections) from the primary and secondary somatosensory cortices, granular insular cortex, and Su5, and ipsilateral projections (or bilateral projections with an ipsilateral predominance) from the dorsal peduncular cortex, bed nuclei of stria terminalis, central amygdaloid nucleus, lateral hypothalamus, parasubthalamic nucleus, trigeminal mesencephalic nucleus, parabrachial nucleus, juxtatrigeminal region, trigeminal oral and caudal subnuclei, and dorsal medullary reticular formation. These findings suggest that the Su5, which receives JCMS proprioception, has efferent and afferent connections with multiple brain regions that are involved in emotional and autonomic functions as well as orofacial motor functions. | Yoshida, Atsushi; Inoue, Misaki; Sato, Fumihiko; Morita, Yayoi; Tsutsumi, Yumi; Furuta, Takahiro; Uchino, Katsuro; Akhter, Fatema; Bae, Yong Chul; Tachibana, Yoshihisa; Inoue, Tomio | Osaka Univ, Grad Sch Dent, Dept Oral Anat & Neurobiol, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan; Takarazuka Univ Med & Hlth Care, Dept Acupuncture, Takarazuka, Hyogo 6660162, Japan; Dar Al Uloom Univ, Coll Dent, Riyadh 11512, Saudi Arabia; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 700412, South Korea; Kobe Univ, Grad Sch Med, Dept Physiol & Cell Biol, Chuo Ku, 7-5-1 Kusunoki, Kobe, Hyogo 6500017, Japan; Showa Univ, Sch Dent, Dept Oral Physiol, Shinagawa Ku, Tokyo 1428555, Japan | Akhter, Fatema/KVY-4522-2024 | 55757780066; 57283989500; 37112998700; 57284206500; 57196150893; 7201372674; 35742156800; 55266749800; 56377838800; 47461520500; 55375715000 | yoshida@dent.osaka-u.ac.jp;yoshi@med.kobe-u.ac.jp; | BRAIN STRUCTURE & FUNCTION | BRAIN STRUCT FUNCT | 1863-2653 | 1863-2661 | 227 | 1 | SCIE | ANATOMY & MORPHOLOGY;NEUROSCIENCES | 2022 | 3.1 | 2.5 | 1.39 | 2025-06-25 | 10 | 9 | Muscle spindle; Mastication; Swallowing; Neuronal tracer; BDA; CTb | PARVICELLULAR RETICULAR-FORMATION; SENSORY NUCLEAR-COMPLEX; LOWER BRAIN-STEM; MESENCEPHALIC TRIGEMINAL NEURONS; SOMATOTOPIC DIRECT PROJECTIONS; DORSAL COLUMN NUCLEAR; INSULAR CORTEX; JAW MOVEMENTS; SUPERIOR COLLICULUS; STRIA TERMINALIS | BDA; CTb; Mastication; Muscle spindle; Neuronal tracer; Swallowing | Animals; Insular Cortex; Intralaminar Thalamic Nuclei; Motor Neurons; Muscle Spindles; Neural Pathways; Proprioception; Rats; Rats, Wistar; tracer; animal experiment; animal tissue; Article; caudal trigeminal nucleus; central nucleus (amygdala); cortex layer V; diencephalon; electric potential; face muscle; hypoglossal nucleus; hypothalamic paraventricular nucleus; insula; lateral hypothalamus; male; mastication; medullary reticular formation; mesencephalic trigeminal nucleus; muscle spindle; nerve cell; nerve ending; nonhuman; oral trigeminal nucleus; parabrachial nucleus; pons; pons reticular formation; pontine nucleus; primary somatosensory cortex; proprioception; rat; stria terminalis; superior colliculus; supratrigeminal nucleus; swallowing; thalamus intralaminar nucleus; thalamus parafascicular nucleus; thalamus ventral nucleus; trigeminal motor nucleus; zona incerta; animal; motoneuron; nerve tract; Wistar rat | English | 2022 | 2022-01 | 10.1007/s00429-021-02391-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | An optimized biofumigant improves pepper yield without exerting detrimental effects on soil microbial diversity | Background: Biofumigation is a non-chemical sustainable approach that reshapes soil microbiota to overcome challenges in way of continuous cultivation. However, the type and quantity of substrate have a significant impact on microbiota shifts and the subsequent success of biofumigation. Moreover, studies on the effects of biofumigant concentration in combination with fumigation duration on soil microbiota dynamics are very rare. Research methods: We performed microcosm experiments to investigate how a biofumigant (Korean canola cultivar, HanRa) at various concentrations (0.5%, 1%, 2-4% w/w: biofumigant/soil) and fumigation periods (2-4 weeks) affects the soil bacterial and fungal communities. Subsequently, pot experiments employing two Korean canola cultivars (HanRa and YongSan) at 1% (w/w) were carried out. Results: Illumina MiSeq analysis revealed that 2-4% biofumigant, regardless of incubation period, had a significant negative impact on microbial diversity and network complexity. In contrast, 1% biofumigant transformed the bacterial, fungal, and inter-kingdom networks into a highly connected and complex network without affecting microbial diversity. Bacillus, Clostridium, and Pseudomonas were the most highly stimulated bacterial genera in the biofumigated soils, whereas the abundance of Acidobacteria members was greatly reduced. The 2-4% amendments had substantially and more differentially abundant Fusarium than the 1%. Soil nutrition (e.g., pH, nitrate, ammonium, and exchangeable potassium), fruit yield, and weed suppression were enhanced in subsequent pot experiments. Of the nine soil chemical properties, phosphate and exchangeable potassium were the main factors influencing the microbial community assembly. Conclusions: Optimized biofumigation-mediated increase in nitrate, ammonium, and potassium availability in the soil without causing any negative effects on soil microbial diversity indicates its potential as a preplant to improve crop productivity. This study contributes significantly to our understanding of how an optimal biofumigant can help ameliorate obstacles in continuous cropping. | Tagele, Setu Bazie; Kim, Ryeong-Hui; Jeong, Minsoo; Jung, Da-Ryung; Lee, Dokyung; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu 41566, South Korea | ; shin, Jaeho/K-6792-2013; Tagele, Setu Bazie/IYJ-1959-2023 | 57202007103; 57222756419; 57292954900; 57221116102; 57961974700; 57224125922 | jhshin@knu.ac.kr; | CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE | CHEM BIOL TECHNOL AG | 2196-5641 | 9 | 1 | SCIE | AGRICULTURE, MULTIDISCIPLINARY | 2022 | 6.6 | 2.6 | 0.55 | 2025-06-25 | 5 | 6 | Biofumigant; Capsaicinoids; Illumina MiSeq; Pepper; Soil microbiota; Weed | ALLYL ISOTHIOCYANATE; COMMUNITY STRUCTURE; FUNGAL COMMUNITY; DISINFESTATION; QUALITY; IMPACT; CHILI | Biofumigant; Capsaicinoids; Illumina MiSeq; Pepper; Soil microbiota; Weed | English | 2022 | 2022-12-19 | 10.1186/s40538-022-00365-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of Preoperative Imaging Modalities for the Assessment of Malignant Potential of Pancreatic Cystic Lesions A Network Meta-analysis | Purpose The aims of this study are to compare the performance of various preoperative imaging modalities for assessing the malignant potential of pancreatic cystic lesions (PCLs) through a network meta-analysis (NMA) and to clarify the role of F-18-FDG PET in the management of patients with PCL. Methods PubMed, EMBASE, and Cochrane Library were searched for the studies evaluating the performance of preoperative imaging modalities for identifying malignant PCLs. The NMA was performed for 4 representative categories of various imaging modalities in terms of diagnostic performance for differentiating malignant from benign PCL and intraductal papillary mucinous neoplasms only as a subgroup analysis. To calculate the probability of each imaging modality being the most effective diagnostic method, the surface under the cumulative ranking curve values were obtained. Results A total of 1018 patients from 17 direct comparison studies using 2 or more preoperative imaging modalities were included for differentiating malignant from benign PCL. The positive predictive value (PPV) and accuracy of F-18-FDG PET were significantly higher than that of CT (PPV: odds ratio [OR], 2.66; 95% credible interval [CrI], 1.21-6.17; accuracy: OR, 2.63; 95% CrI, 1.41-5.38) or MRI (PPV: OR, 2.50; 95% CrI, 1.09-6.26; accuracy: OR, 2.50; 95% CrI, 1.28-5.47) in all PCLs, as well as in the subgroup analysis for intraductal papillary mucinous neoplasm only. F-18-FDG PET showed the highest surface under the cumulative ranking curve values in all diagnostic performance areas of sensitivity, specificity, PPV, negative predictive value, and accuracy, followed by MRI or CT. Conclusions The results from this NMA suggest that F-18-FDG PET is the best preoperative imaging modality for differentiating malignant from benign PCLs and that it can be used for the preoperative evaluation of PCLs. | Lee, Sang-Woo; Shim, Sung Ryul; Jeong, Shin Young; Kim, Seong-Jang | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Kyungnam Univ, Coll Hlth Sci, Dept Hlth & Med Informat, Chang Won, South Korea; Pusan Natl Univ, Coll Med, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Nucl Med, Yangsan 50612, South Korea; Pusan Natl Univ, Yangsan Hosp, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea | Kim, Yun Hak/ABF-3331-2021; lee, sangwoo/KUD-1906-2024 | 57196249819; 55072270800; 36164032500; 35810391700 | growthkim@daum.net; | CLINICAL NUCLEAR MEDICINE | CLIN NUCL MED | 0363-9762 | 1536-0229 | 47 | 10 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 10.6 | 2.6 | 0.42 | 2025-06-25 | 2 | 3 | imaging; malignancy; network meta-analysis; pancreatic cystic lesion | PAPILLARY MUCINOUS NEOPLASMS; POSITRON-EMISSION-TOMOGRAPHY; INTERNATIONAL CONSENSUS GUIDELINES; COMPUTED-TOMOGRAPHY; DIAGNOSTIC PERFORMANCE; DIFFERENTIAL-DIAGNOSIS; CLINICAL UTILITY; MULTIDETECTOR CT; BRANCH DUCT; MANAGEMENT | imaging; malignancy; network meta-analysis; pancreatic cystic lesion | Diagnosis, Differential; Fluorodeoxyglucose F18; Humans; Network Meta-Analysis; Pancreatic Cyst; Pancreatic Neoplasms; Positron-Emission Tomography; Sensitivity and Specificity; fluorodeoxyglucose f 18; adult; Article; Cochrane Library; controlled study; diagnostic procedure; diagnostic test accuracy study; diagnostic value; Embase; female; human; intermethod comparison; intraductal papillary mucinous tumor; major clinical study; male; malignant neoplasm; Medline; meta analysis; network meta-analysis; nuclear magnetic resonance imaging; predictive value; preoperative evaluation; probability; sensitivity and specificity; surgery; systematic review; diagnostic imaging; differential diagnosis; network meta-analysis; pancreas cyst; pancreas tumor; pathology; positron emission tomography; procedures | English | 2022 | 2022-10 | 10.1097/rlu.0000000000004323 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Diagnostic Performance of ¹⁸F-FDG PET/CT for Lymph Node Staging in Penile Cancer | Objective The purpose of the current study was to evaluate the diagnostic accuracies of F-18-FDG PET/CT for detection of lymph node (LN) metastasis in penile cancer (PeCA) patients through a systematic review and meta-analysis. Patients and Methods The PubMed, Cochrane database, and Embase database, from the earliest available date of indexing through August 31, 2021, were searched for studies evaluating diagnostic performance of F-18-FDG PET/CT for detection of metastatic LN in PeCA patients. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-, respectively), and constructed summary receiver operating characteristic curves. Results Across 12 studies (479 patients), the pooled sensitivity of F-18-FDG PET/CT was 0.87 (95% confidence interval [CI], 0.79-0.92) and the pooled specificity was 0.88 (95% CI, 0.79-0.93). Likelihood ratio syntheses gave an overall LR+ of 7.2 (95% CI, 3.9-13.1) and LR- of 0.15 (95% CI, 0.1-0.24). The pooled diagnostic odds ratio was 47 (95% CI, 19-116). In meta-regression analysis, no variable was the source of the study heterogeneity. Conclusions F-18-FDG PET/CT showed a good diagnostic performances for detection of metastatic LN in PeCA patients. Also, F-18-FDG PET/CT revealed similar diagnostic accuracy for detection of inguinal and pelvic LN metastasis in PeCA patients. | Lee, Sang Woo; Kim, Seong-Jang | Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu, South Korea; Sch Med, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan, South Korea; Pusan Natl Univ, Dept Nucl Med, Yangsan Hosp, Yangsan, South Korea | Kim, Yun Hak/ABF-3331-2021; lee, sangwoo/KUD-1906-2024 | 57196249819; 35810391700 | swleenm@knu.ac.kr;growthkim@daum.net; | CLINICAL NUCLEAR MEDICINE | CLIN NUCL MED | 0363-9762 | 1536-0229 | 47 | 5 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 10.6 | 2.6 | 1.25 | 2025-06-25 | 9 | 10 | F-18-FDG; PET; CT; penile cancer; lymph node | SQUAMOUS-CELL CARCINOMA; TEST ACCURACY; METAANALYSIS; TOMOGRAPHY; INVOLVEMENT; BIAS | <sup>18</sup>F-FDG; lymph node; penile cancer; PET/CT | Fluorodeoxyglucose F18; Humans; Lymph Nodes; Male; Neoplasm Staging; Penile Neoplasms; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Sensitivity and Specificity; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; Article; cancer patient; cancer staging; diagnostic accuracy; diagnostic value; false negative result; false positive result; human; lymph node metastasis; male; meta analysis; penis cancer; positron emission tomography-computed tomography; predictive value; receiver operating characteristic; sensitivity and specificity; systematic review; cancer staging; diagnostic imaging; lymph node; pathology; penis tumor; positron emission tomography-computed tomography | English | 2022 | 2022-05 | 10.1097/rlu.0000000000004081 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Expansion of the prime editing modality with Cas9 from Francisella novicida | Prime editing can induce a desired base substitution, insertion, or deletion in a target gene using reverse transcriptase after nick formation by CRISPR nickase. In this study, we develop a technology that can be used to insert or replace external bases in the target DNA sequence by linking reverse transcriptase to the Francisella novicida Cas9, which is a CRISPR-Cas9 ortholog. Using FnCas9(H969A) nickase, the targeting limitation of existing Streptococcus pyogenes Cas9 nickase [SpCas9(H840A)]-based prime editing is dramatically extended, and accurate prime editing is induced specifically for the target genes in human cell lines. | Oh, Yeounsun; Lee, Wi-jae; Hur, Junho K.; Song, Woo Jeung; Lee, Youngjeon; Kim, Hanseop; Gwon, Lee Wha; Kim, Young-Hyun; Park, Young-Ho; Kim, Chan Hyoung; Lim, Kyung-Seob; Song, Bong-Seok; Huh, Jae-Won; Kim, Sun-Uk; Jun, Bong-Hyun; Jung, Cheulhee; Lee, Seung Hwan | Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr NPRC, Cheongju, South Korea; Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul, South Korea; Konkuk Univ, Dept Biosci & Biotechnol, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Genet, Seoul 04763, South Korea; Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul 04763, South Korea; Chung Ang Univ, Dept Life Sci, Seoul 06974, South Korea; Hanyang Univ, Grad Sch, Dept Med, Major Med Genet, Seoul 04763, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Korea Univ Sci & Technol, KRIBB Sch Biosci, Dept Biomol Sci, Daejeon, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr FARRC, Cheongju, South Korea; Chungnam Natl Univ, Dept Biol Sci, Daejeon, South Korea; Korea Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea | Hur, Junho/ADK-0757-2022; Kim, Sunuk/KJM-5211-2024; Lee, Youngjeon/LZH-8969-2025 | 57218169850; 57218165418; 35740323500; 57218860580; 57199022088; 57203630238; 56986646700; 54393408600; 56246852400; 57224822365; 36470521900; 8860759100; 16645802900; 8278891100; 35229652600; 23480057100; 57202327400 | damo363@korea.ac.kr;lsh080390@cau.ac.kr; | GENOME BIOLOGY | GENOME BIOL | 1474-760X | 23 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;GENETICS & HEREDITY | 2022 | 12.3 | 2.6 | 2.2 | 2025-06-25 | 25 | 22 | Prime editing; Target expansion; CRISPR-Cas9; Ortholog; Francisella novicida | GENOMIC DNA; DUAL-RNA; BASE | CRISPR-Cas9; Francisella novicida; Ortholog; Prime editing; Target expansion | CRISPR-Cas Systems; Deoxyribonuclease I; Francisella; Gene Editing; Humans; RNA-Directed DNA Polymerase; CRISPR associated endonuclease Cas9; RNA directed DNA polymerase; deoxyribonuclease I; RNA directed DNA polymerase; Article; clustered regularly interspaced short palindromic repeat; controlled study; CRISPR-CAS9 system; DNA sequence; Francisella novicida; gene editing; gene targeting; human; human cell; nonhuman; orthology; prime editing; Streptococcus pyogenes; CRISPR Cas system; Francisella; metabolism | English | 2022 | 2022-04-11 | 10.1186/s13059-022-02644-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial | Background: A limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods: Herein, we performed comprehensive molecular characterization of immediate (D-42 to D-1) pre-treatment tumor biopsy specimens from 60 patients with sorafenib-failed HCC in a single-arm prospective phase II trial of pembrolizumab. Objective response rate was the primary efficacy endpoint. We used whole-exome sequencing, RNA sequencing, and correlative analysis. In addition, we performed single-cell RNA sequencing using peripheral blood mononuclear cells. Results: The overall response rate of pembrolizumab in sorafenib-failed HCC patients was 10% ([6/60] 95% CI, 2.4-17.6). In a univariate analysis using clinicopathological features, female gender, PD-L1 positivity, and low neutrophil-to-lymphocyte ratio (NLR) were identified as contributing factors to pembrolizumab response. Somatic mutations in CTNNB1 and genomic amplifications in MET were found only in non-responders. Transcriptional profiles through RNA sequencing identified that pembrolizumab responders demonstrated T cell receptor (TCR) signaling activation with expressions of MHC genes, indicating increased levels of T cell cytotoxicity. In single-cell sequencing from 10 pre- and post-treatment peripheral blood mononuclear cells (PBMCs), patients who achieved a partial response or stable disease exhibited immunological shifts toward cytotoxic CD8+ T cells. Conversely, patients with progressive disease showed an increased number of both CD14+ and CD16+ monocytes and activation of neutrophil-associated pathways. Conclusions: Taken together, HCC patients with infiltration of cytotoxic T cells, along with increased active circulating CD8+ T cells during pembrolizumab treatment and down-regulation of neutrophil-associated markers, significantly benefited from pembrolizumab treatment. | Hong, Jung Yong; Cho, Hee Jin; Sa, Jason K.; Liu, Xiaoqiao; Ha, Sang Yun; Lee, Taehyang; Kim, Hajung; Kang, Wonseok; Sinn, Dong Hyun; Gwak, Geum-Youn; Choi, Moon Seok; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon; Park, Hee Chul; Kang, Tae Wook; Rhim, Hyunchul; Lee, Su Jin; Cristescu, Razvan; Lee, Jeeyun; Paik, Yong Han; Lim, Ho Yeong | Sungkyunkwan Univ, Div Gastroenterol, Dept Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Div Hematol Oncol, Dept Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; Precis Med Res Inst, Innovat Therapeut Res Ctr, Samsung Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; Korea Univ, Dept Biomed Sci, Coll Med, Seoul, South Korea; Merck & Co Inc, Kenilworth, NJ USA; Sungkyunkwan Univ, Dept Pathol & Translat Genom, Samsung Med Ctr, Sch Med, Seoul, South Korea; Sungkyunkwan Univ Sch Med, Dept Radiat Oncol, Samsung Med Ctr, Seoul, South Korea; Sungkyunkwan Univ, Dept Radiol & Ctr Imaging Sci, Samsung Med Ctr, Sch Med, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea | Gwak, Geum/F-4605-2014; Kan, Tae Wook/CAI-4750-2022; Lee, Jee/C-9646-2011; Lim, Ho Yeong/KBA-8868-2024; Sinn, Dong/JAC-4247-2023 | 57212848586; 55937716400; 56803454400; 56438749600; 56405966100; 35215634200; 57191722015; 19640141000; 23493891100; 6506218992; 55661123900; 59454469400; 7202345168; 7102643032; 7601567098; 55707929600; 7006154219; 55931708700; 35309597000; 55899617000; 8423833300; 36838556200 | yh.paik@skku.edu;hoylim@skku.edu; | GENOME MEDICINE | GENOME MED | 1756-994X | 14 | 1 | SCIE | GENETICS & HEREDITY | 2022 | 12.3 | 2.6 | 5.85 | 2025-06-25 | 65 | 61 | Carcinoma; Hepatocellular; Pembrolizumab; Biomarkers; Tumor | C-MET; HYPOXIC CONDITIONS; MONOTHERAPY; RESISTANCE; LANDSCAPE; RESPONSES; EFFICACY | Biomarkers; Carcinoma; Hepatocellular; Pembrolizumab; Tumor | Antibodies, Monoclonal, Humanized; Carcinoma, Hepatocellular; Female; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Prospective Studies; T-Lymphocytes, Cytotoxic; antineoplastic agent; CD14 antigen; CD16 antigen; CD8 antigen; pembrolizumab; programmed death 1 receptor; scatter factor receptor; sorafenib; T lymphocyte receptor; monoclonal antibody; pembrolizumab; adult; aged; Article; cancer control; cancer genetics; cancer immunotherapy; cancer patient; CD14+ monocyte; CD16+ monocyte; CD8+ T lymphocyte; clinical feature; correlation analysis; cytotoxic T lymphocyte; cytotoxicity; down regulation; drug effect; drug efficacy; female; gender; gene amplification; gene expression; histopathology; human; human cell; human tissue; leukocyte activation; liver cell carcinoma; lymphocyte count; lymphocytic infiltration; major clinical study; male; MHC gene; molecular pathology; monocyte; monocyte count; multiple cycle treatment; neutrophil lymphocyte ratio; open study; overall response rate; peripheral blood mononuclear cell; phase 2 clinical trial; prospective study; RNA sequencing; RNA transcription; somatic mutation; TCR signaling; tumor biopsy; tumor immunity; very elderly; whole exome sequencing; clinical trial; cytotoxic T lymphocyte; genetics; liver tumor; mononuclear cell; pathology | English | 2022 | 2022-01-06 | 10.1186/s13073-021-00995-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer | The human microbiome plays an essential role in the human immune system, food digestion, and protection from harmful bacteria by colonizing the human intestine. Recently, although the human microbiome affects colorectal cancer (CRC) treatment, the mode of action between the microbiome and CRC remains unclear. This study showed that propionate suppressed CRC growth by promoting the proteasomal degradation of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) through HECT domain E3 ubiquitin protein ligase 2 (HECTD2) upregulation. In addition, EHMT2 downregulation reduced the H3K9me2 level on the promoter region of tumor necrosis factor alpha-induced protein 1 (TNFAIP1) as a novel direct target of EHMT2. Subsequently, TNFAIP1 upregulation induced the apoptosis of CRC cells. Furthermore, using Bacteroides thetaiotaomicron culture medium, we confirmed EHMT2 downregulation via upregulation of HECTD2 and TNFAIP1 upregulation. Finally, we observed the synergistic effect of propionate and an EHMT2 inhibitor (BIX01294) in 3D spheroid culture models. Thus, we suggest the anticancer effects of propionate and EHMT2 as therapeutic targets for colon cancer treatment and may provide the possibility for the synergistic effects of an EHMT2 inhibitor and microbiome in CRC treatment. | Ryu, Tae Young; Kim, Kwangho; Han, Tae-Su; Lee, Mi-Ok; Lee, Jinkwon; Choi, Jinhyeon; Jung, Kwang Bo; Jeong, Eun-Jeong; An, Da Mi; Jung, Cho-Rok; Lim, Jung Hwa; Jung, Jaeeun; Park, Kunhyang; Lee, Moo-Seung; Kim, Mi-Young; Oh, Soo Jin; Hur, Keun; Hamamoto, Ryuji; Park, Doo-Sang; Kim, Dae-Soo; Son, Mi-Young; Cho, Hyun-Soo | Korea Res Inst Biosci & Biotechnol, Daejeon 34141, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Biol Sci, Daejeon 34141, South Korea; Korea Univ Sci & Technol, Daejeon 34113, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Asan Inst Life Sci, Seoul 05505, South Korea; Univ Ulsan, Coll Med, Dept Convergence Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Natl Canc Ctr, Div Mol Modificat & Canc Biol, Tokyo 1040045, Japan | ; Hamamoto, Ryuji/AAF-9600-2019; Jung, Woo-Bin/IXN-0662-2023; Kim, Young Hoon/F-5424-2012; Hur, Keun/G-9513-2011; PARK, JUN-YOUNG/P-5981-2015 | 57204715311; 57200561661; 26424339800; 35750102400; 57226003200; 57205176881; 57194018616; 57205177104; 57405444700; 57194011220; 36523358200; 57213798623; 37075471300; 55626176100; 57207943249; 57203264676; 8861888000; 6701794416; 17233878700; 8056858000; 7004301289; 56508722000 | dspark@kribb.re.kr;kds2465@kribb.re.kr;myson@kribb.re.kr;chohs@kribb.re.kr; | ISME JOURNAL | ISME J | 1751-7362 | 1751-7370 | 16 | 5 | SCIE | ECOLOGY;MICROBIOLOGY | 2022 | 11 | 2.6 | 8.53 | 2025-06-25 | 77 | 74 | CHAIN FATTY-ACIDS; HISTONE-DEACETYLASE ACTIVITY; COLON-CANCER; ADJUVANT CHEMOTHERAPY; METASTASIS; INHIBITION; EXPRESSION; PROTEIN; TNFAIP1 | Colorectal Neoplasms; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Microbiota; Propionates; Up-Regulation; EHMT2 protein, human; histocompatibility antigen; histone lysine methyltransferase; propionic acid derivative; apoptosis; biodegradation; cancer; cell component; degradation; growth; inhibitor; protein; tumor; colorectal tumor; genetics; human; metabolism; microflora; upregulation | English | 2022 | 2022-05 | 10.1038/s41396-021-01119-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Is Delayed Image of ¹⁸F-FDG PET/CT Necessary for Mediastinal Lymph Node Staging in Non-Small Cell Lung Cancer Patients? | Purpose The purpose of this study was to evaluate the diagnostic accuracies of dual-time-point (DTP) F-18-FDG PET/CT for detection of mediastinal lymph node (LN) metastasis in non-small cell lung cancer (NSCLC) patients through a systematic review and meta-analysis. Patients and Methods The PubMed, Cochrane database, and EMBASE database, from the earliest available date of indexing through October 31, 2021, were searched for studies evaluating diagnostic performance of DTP F-18-FDG PET/CT for detection of metastatic mediastinal LN in NSCLC patients. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves. Results Ten studies (758 patients) were included in the current study. In patient-based analysis, early image showed a sensitivity of 0.76 and a specificity of 0.75. Delayed image revealed a sensitivity of 0.84 and a specificity of 0.71. In LN-based analysis, early image showed a sensitivity of 0.80 and a specificity of 0.83. Delayed image revealed a sensitivity of 0.84 and a specificity of 0.87. Retention index or %Delta SUVmax is superior to early or delayed images of DTP F-18-FDG PET/CT for detection of mediastinal LN metastasis. Conclusions Dual-time-point F-18-FDG PET/CT showed a good diagnostic performances for detection of metastatic mediastinal LNs in NSCLC patients. Early and delayed images of DTP F-18-FDG PET/CT revealed similar diagnostic accuracies for LN metastasis. However, retention index or %Delta SUVmax is superior to early or delayed images of DTP F-18-FDG PET/CT for detection of mediastinal LN metastasis in NSCLC patients. Further large multicenter studies would be necessary to substantiate the diagnostic accuracy of DTP F-18-FDG PET/CT for mediastinal LN staging in NSCLC patients. | Lee, Sang Woo; Kim, Seong-Jang | Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu, South Korea; Sch Med, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Nucl Med, Yangsan, South Korea | Kim, Yun Hak/ABF-3331-2021; lee, sangwoo/KUD-1906-2024 | 57196249819; 35810391700 | growthkim@daum.net; | CLINICAL NUCLEAR MEDICINE | CLIN NUCL MED | 0363-9762 | 1536-0229 | 47 | 5 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 10.6 | 2.6 | 1.11 | 2025-06-25 | 9 | 8 | F-18-FDG; PET; CT; NSCLC; lymph node; dual-time-point | DUAL-TIME-POINT; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; DIAGNOSTIC-TEST ACCURACY; FDG PET/CT; BENIGN; METAANALYSIS; METASTASIS; HEAD; PERFORMANCE; PREDICTOR | <sup>18</sup>F-FDG; dual-time-point; lymph node; NSCLC; PET/CT | Carcinoma, Non-Small-Cell Lung; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Lymph Nodes; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Sensitivity and Specificity; fluorodeoxyglucose f 18; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; Article; comparative study; diagnostic accuracy; female; human; image analysis; lymph node metastasis; male; mediastinum metastasis; meta analysis; non small cell lung cancer; positron emission tomography; positron emission tomography-computed tomography; sensitivity and specificity; systematic review; cancer staging; diagnostic imaging; lung tumor; lymph node; pathology; positron emission tomography-computed tomography; procedures | English | 2022 | 2022-05 | 10.1097/rlu.0000000000004110 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Moxifloxacin-Based Extended Depth-of-Field Fluorescence Microscopy for Real-Time Conjunctival Goblet Cell Examination | Conjunctival goblet cells (CGCs) are mucin-secreting cells in the eye and play essential roles for ocular surface homeostasis. Since various ocular surface pathologies are related to CGC dysfunction, CGC examination is important for the evaluation of ocular surface conditions. Recently we introduced moxifloxacin-based fluorescence microscopy (MBFM) for non-invasive CGC imaging. However, the imaging speed was up to 1 frame per second (fps) and needed to be improved for clinical applications. In this study, we developed a high-speed moxifloxacin-based, extended depth-of-field (EDOF) microscopy system that operates at a maximum imaging speed of 15 fps. The system used a deformable mirror for the high-speed axial sweeping of focal plane during single-frame acquisitions. The acquired images contained both in-focus and out-offocus information, and deconvolution was used to filter the in-focus information. The system had a DOF of 800 mu m, field-of-view of 1.2 mm x 1.2 mm, and resolution of 2.3 mu m. Its performance was demonstrated by real-time, breathing-motion-insensitive CGC imaging of mouse and rabbit models, in vivo. High-speed EDOF microscopy has potentials for non-invasive, real-time CGC examinations of human subjects. | Lee, Jungbin; Kim, Seonghan; Kim, Jeongho; Son, Byeong Jae; Yoon, Chang Ho; Kim, Hong Kyun; Kim, Ki Hean | Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 37673, Gyeongsangbuk, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41940, South Korea; Seoul Natl Univ, Dept Ophthalmol, Coll Med, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Biomed Res Inst, Seoul Artificial Eye Ctr, Lab Ocular Regenerat Med & Immunol, Seoul 03080, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, Daegu 41940, South Korea; Yonsei Univ, Inst Convergence Res & Educ Adv Technol, Seoul 03722, South Korea | Kim, Seong/J-5408-2012; Lee, Jungho/AAJ-7137-2020 | 57211524471; 57213778407; 57219385573; 57197444337; 55939101100; 57218260940; 34770690200 | jungbinlee@postech.ac.kr;seonghan@postech.ac.kr;mapperkim@gmail.com;supersbj@daum.net;ifree7@gmail.com;okeye@daum.net;kiheankim@postech.ac.kr; | IEEE TRANSACTIONS ON MEDICAL IMAGING | IEEE T MED IMAGING | 0278-0062 | 1558-254X | 41 | 8 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;ENGINEERING, ELECTRICAL & ELECTRONIC;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 10.6 | 2.6 | 0.6 | 2025-06-25 | 7 | 7 | Extended depth-of-field; fluorescence microscopy; conjunctival goblet cell; high-speed imaging; ocular surface diseases | BINARY-PHASE FILTERS; CONFOCAL MICROSCOPY; IMPRESSION CYTOLOGY; DENSITY; FOCUS; DIAGNOSIS; LENS | conjunctival goblet cell; Extended depth-of-field; fluorescence microscopy; high-speed imaging; ocular surface diseases | Animals; Conjunctiva; Goblet Cells; Humans; Microscopy, Fluorescence; Moxifloxacin; Rabbits; Cytology; Fluorescence; Fluorescence microscopy; Speed; moxifloxacin; Cell imaging; Conjunctival goblet cell; Extended depth of field; Frames per seconds; High Speed; High speed imaging; Imaging speed; Moxifloxacin; Ocular surface disease; Real- time; animal; conjunctiva; diagnostic imaging; fluorescence microscopy; goblet cell; human; Leporidae; metabolism; procedures; Cells | English | 2022 | 2022-08 | 10.1109/tmi.2022.3151944 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Plasma exchange: An effective method to eliminate neurotoxic lipophilic chemicals from blood | Kang, Kyunghun; Lee, Ho-won; Lee, Duk-Hee | Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 55365592200; 35337240700; 57211851121 | lee_dh@knu.ac.kr; | ALZHEIMERS & DEMENTIA | ALZHEIMERS DEMENT | 1552-5260 | 1552-5279 | 18 | 12 | SCIE | CLINICAL NEUROLOGY | 2022 | 14 | 2.6 | 0.4 | 2025-06-25 | 1 | 1 | PERSISTENT ORGANIC POLLUTANTS; ADIPOSE-TISSUE; OBESITY | Humans; Plasma Exchange; neurotoxin; polychlorinated biphenyl; adipose tissue; Alzheimer disease; body burden; degenerative disease; dementia; human; Letter; lipophilicity; neurotoxicity; obesity; persistent organic pollutant; plasma exchange | English | 2022 | 2022-12 | 10.1002/alz.12739 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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