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| ○ | ○ | Article | Incidence and risk factors of immune checkpoint inhibitor-induced colitis in Korean patients with cancer | Background/Aims: Immune checkpoint inhibitors (ICIs) are effective in treating cancer. However, various immune-related adverse events (irAEs) have become prevalent, with ICI-induced colitis being the most common gastrointestinal irAE. Thus, we aimed to investigate the incidence and risk factors of ICI-induced colitis in Korean patients with cancer. Methods: This retrospective study included patients treated with ICIs between October 2015 and June 2022 in two tertiary referral centers in Daegu, Korea. The incidence of ICI-induced colitis was determined using electronic medical records. Risk factors for ICI-induced colitis were identified using univariate and multivariate logistic regression analyses. Results: We included 1,478 patients with ICI-treated cancer. The incidence of ICI-induced colitis was 3.5% (n = 52/1,478). Multivariate logistic regression analysis showed that the combination of nivolumab and ipilimumab was a risk factor for ICI-induced colitis = 0.006; odds ratio, 9.768; 95% confidence interval, 1.93-49.30). Conclusions: ICI-induced colitis had an incidence rate of 3.5% and was associated with the combination of nivolumab and ipilimumab. Most patients with ICI-induced colitis developed mild symptoms that improved with supportive care alone, making ICI therapy resumption possible. | Kim, Tae Kyun; Lee, Hyun Seok; Kim, Eun Soo | Kyungpook Natl Univ, Chilgok Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Sang/J-5398-2012; Kim, Tae/AAG-1037-2021 | 59512545600; 36647886100; 59326995400 | lhsworld@nate.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 11.76 | 2025-05-07 | 1 | 3 | Immune checkpoint inhibitors; Colitis | Colitis; Immune checkpoint inhibitors | Adult; Aged; Aged, 80 and over; Colitis; Female; Humans; Immune Checkpoint Inhibitors; Incidence; Ipilimumab; Male; Middle Aged; Neoplasms; Nivolumab; Republic of Korea; Retrospective Studies; Risk Assessment; Risk Factors; avelumab; durvalumab; immune checkpoint inhibitor; ipilimumab; nivolumab; pembrolizumab; immune checkpoint inhibitor; ipilimumab; nivolumab; adult; aged; Article; cancer patient; colitis; disease severity; drug induced disease; electronic medical record; female; human; incidence; Korean (people); major clinical study; male; malignant neoplasm; multivariate logistic regression analysis; retrospective study; risk assessment; risk factor; clinical trial; colitis; drug therapy; epidemiology; immunology; middle aged; multicenter study; neoplasm; risk factor; South Korea; very elderly | English | 2025 | 2025-01 | 10.3904/kjim.2024.135 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Medical disputes involving lower gastrointestinal endoscopies: cases from the Korean Medical Dispute Mediation and Arbitration Agency | Background/Aims: As the number of lower gastrointestinal endoscopies and high-risk examinees increases, the incidence of adverse events associated with these endoscopies has also increased. Medical disputes and lawsuits related to adverse events are rapidly increasing. Methods: Medical disputes related to lower gastrointestinal endoscopy that had been filed in Korean Medical Dispute Me-diation and Arbitration Agency (K-medi) from April 2012 to August 2020 were evaluated with the corresponding medical re-cords and written appraisal. Facilities, patients, procedures, adverse events, and outcome-related variables related to medical disputes were analyzed. Results: As the number of lower gastrointestinal endoscopies in Korea increases each year, the number of medical disputes related to lower gastrointestinal endoscopy appraised by K-medi has also increased yearly during the same period. Among the 121 cases analyzed, 86 (71.1%) were conciliated and 35 (28.9%) were cosigned by prosecution. Perforations accounted for the largest proportion of cases (93 cases, 76.9%). Most patients (n = 119, 98.3%) underwent non-emergent procedures, and only 10 (8.3%) underwent them for therapeutic purposes. Approximately one-fifth of the patients (n = 25, 20.7%) died. Conclusions: The number of medical disputes related to lower gastrointestinal endoscopy are increasing. To prevent this, it is important to review the data on existing cases and establish specific response guidelines. | Oh, Eun Hye; Shin, Jeong Eun; Bae, Jun Yong; Lee, Yoon Suk; Park, Yehyun; Kwon, Yong Hwan; Paik, Chang Nyol; Lee, Jun Kyu; Lee, Tae Hee | Hanyang Univ, Guri Hosp, Coll Med, Dept Internal Med, Guri, South Korea; Dankook Univ, Coll Med, Dankook Univ Hosp, Dept Internal Med, Cheonan, South Korea; Seoul Med Ctr, Dept Internal Med, Seoul, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Coll Med, Goyang, South Korea; Ewha Womans Univ, Ewha Womans Univ Seoul Hosp, Coll Med, Dept Internal Med,Div Nephrol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Catholic Univ Korea, St Vincent Hosp, Coll Med, Dept Internal Med, Suwon, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Soonchunhyang Univ, Soonchunhyang Univ Hosp, Coll Med, Inst Digest Res, Seoul, South Korea; Soonchunhyang Univ, Inst Digest Res, Digest Dis Ctr, Dept Internal Med,Coll Med, 59 Daesagwan ro, Seoul 04401, South Korea | Lee, Yoon Suk/D-1827-2019; Oh, Eun Hye/JZT-2160-2024; LEE, Yoon-Suk/D-1827-2019 | 57193574603; 59903367500; 57577963400; 57219432560; 55551648800; 55775556800; 15058072500; 59903262500; 59903181600 | iman0825@naver.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-06-11 | 0 | 0 | Patient safety; Medical litigation; Medical accidents; Medical errors; Colonoscopy | ADVERSE EVENTS; MANAGEMENT | Colonoscopy; Medical accidents; Medical errors; Medical litigation; Patient safety | Adult; Aged; Dissent and Disputes; Endoscopy, Gastrointestinal; Female; Humans; Male; Middle Aged; Negotiating; Republic of Korea; Retrospective Studies; adult; adverse event; aged; Article; clinical decision making; digestive system perforation; female; gastrointestinal endoscopy; health care facility; human; lower gastrointestinal tract; major clinical study; male; medical dispute; medical error; medical record; medicolegal aspect; mortality rate; outcome variable; prosecution; retrospective study; South Korea; interpersonal conflict; middle aged; mortality; negotiation | English | 2025 | 2025-05 | 10.3904/kjim.2024.343 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes | Background/Aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and BMI in diabetic patients, focusing on the impact of past obesity on current adiponectin levels. Methods: We conducted an observational study analyzing data from 323 diabetic patients at Kyungpook National University Hospital. Based on past and current BMIs, participants were categorized into never-obese (nn, n = 106), previously obese (on, n = 43), and persistently obese (oo, n = 73) groups based on a BMI threshold of 25 kg/m2. Adiponectin level and BMI were key variables. Kaplan-Meier analysis assessed their impact on all-cause mortality up to August 2023, with survival differences based on adiponectin quartiles and follow-up starting from patient enrollment (2010-2015). Results: The analysis revealed a significant inverse correlation between adiponectin level and past maximum BMI. The on group exhibited approximately 10% lower adiponectin levels compared to the nn group. This association remained significant after adjusting for current BMI, age, and sex, highlighting the lasting influence of previous obesity on adiponectin levels. Furthermore, survival analysis indicated that patients in the lowest adiponectin quartile had reduced survival, with a statistically significant trend (p = 0.062). Conclusions: Findings of this study suggest that lower adiponectin levels, potentially reflecting past obesity, are associated with decreased survival in diabetic patients, underscoring a critical role of adiponectin in long-term health outcomes. | Kim, Min-Ji; Kim, Sung-Woo; Ha, Bitna; Kim, Hyang Sook; Kwon, So-Hee; Jin, Jonghwa; Choi, Yeon-Kyung; Park, Keun-Gyu; Kim, Jung Guk; Lee, In-Kyu; Jeon, Jae-Han | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Min-Ji/Z-5205-2019; Kwon, So/AAG-8971-2020 | 57206189095; 57206876109; 59707506800; 59707742200; 58784897000; 57223246243; 35335932600; 57202558343; 16506485900; 59060573600; 36910340400 | jeonjh@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 3.92 | 2025-05-07 | 0 | 1 | Adiponectin; Body mass index; Obesity; Type 2 diabetes; Survival analysis | ACTIVATED PROTEIN-KINASE; FATTY-ACID OXIDATION; BODY-MASS INDEX; INSULIN-RESISTANCE; ADIPOSE-TISSUE; PLASMA ADIPONECTIN; METABOLIC SYNDROME; WEIGHT-LOSS; HYPOADIPONECTINEMIA; ASSOCIATION | Adiponectin; Body mass index; Obesity; Survival analysis; Type 2 diabetes | Adiponectin; Aged; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Obesity; Prognosis; Republic of Korea; Risk Factors; Time Factors; adiponectin; alanine aminotransferase; aspartate aminotransferase; C reactive protein; creatinine; glucose; hemoglobin A1c; high density lipoprotein; low density lipoprotein; triacylglycerol; adiponectin; ADIPOQ protein, human; biological marker; adult; alanine aminotransferase blood level; albumin to creatinine ratio; all cause mortality; Article; aspartate aminotransferase blood level; body mass; cohort analysis; controlled study; creatinine blood level; female; glucose blood level; hemoglobin blood level; high risk population; human; lipoprotein blood level; major clinical study; male; middle aged; mortality; mortality rate; non insulin dependent diabetes mellitus; obesity; observational study; overall survival; predictive value; prognosis; protein blood level; protein function; retrospective study; risk assessment; risk factor; survival analysis; survival rate; triacylglycerol blood level; aged; blood; body mass; diagnosis; epidemiology; Kaplan Meier method; mortality; South Korea; time factor | English | 2025 | 2025-03 | 10.3904/kjim.2024.221 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia | Background/Aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retro spective study compared treatment outcomes and induction mortality according to backbone regimen intensity. Methods: The data of 132 patients diagnosed with Ph-positive ALL were retrospectively collected from five centers. Patients received imatinib plus intensive chemotherapy (modified VPD, KALLA1407, or hyper-CVAD) or reduced-intensity chemotherapy (EWALL) for curative purposes. This study analyzed 117 patients, of which 35,22,46, and 14 received modified VPD, KALLA1407, hyper-CVAD, and EWALL, respectively. All patients used imatinib as a TKI. Results: The median age of the patients who received reduced-intensity chemotherapy was 64.4 years, while that of the patients with intensive regimens was 47.5 years. There was no induction death in the reduced-intensity group, while nine patients died in the intensive therapy group. Major molecular response achievement tended to be higher in the intensive chemotherapy group than in the reduced-intensity group. More patients in the intensive chemotherapy group received allogeneic stem cell transplantation (allo-SCT). There was no statistically significant difference in long-term survival between the two groups in terms of relapse-free survival and overall survival rates. Conclusions: When imatinib plus reduced-intensity therapy was used as a frontline treatment, there was no inferiority in obtaining complete remission compared to imatinib plus intensive chemotherapy or significant difference in long-term survival. Since imatinib plus reduced-intensity therapy has limitations in obtaining a deep molecular response, proceeding to allo-SCT should be considered. | Lee, Jung Min; Kim, Do Young; Cho, Hee Jeong; Moon, Joon Ho; Sohn, Sang Kyun; Shin, Ho Jin; Do, Young Rok; Heo, Mi Hwa; Kim, Min Kyoung; Park, Young Seob; Baek, Dong Won | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, 130 Dongdeok ro, Daegu 41944, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Sch Med,Div Hematol Oncol, Busan, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Hemato Oncol, Daegu, South Korea; Yeungnam Univ, Coll Med, Med Ctr, Dept Internal Med, Daegu, South Korea | Lee, Jung-Min/L-8227-2016 | 57211561890; 57206099586; 57216754907; 56568642700; 13310226800; 16239868400; 8960168300; 57217563491; 57206000629; 59514055300; 57191874272 | baekdw83@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-05-07 | 0 | 0 | Philadelphia chromosome; Acute lymphoblastic leukemia; Tyrosine kinase inhibitor; Stem cell transplantation | HYPER-CVAD; 1ST-LINE THERAPY; SINGLE-CENTER; IMATINIB; COMBINATION; PONATINIB; SURVIVAL; ADULTS | Acute lymphoblastic leukemia; Philadelphia chromosome; Stem cell transplantation; Tyrosine kinase inhibitor | Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Male; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Republic of Korea; Retrospective Studies; Time Factors; Transplantation, Homologous; Treatment Outcome; Tyrosine Kinase Inhibitors; imatinib; antineoplastic agent; imatinib; protein kinase inhibitor; protein tyrosine kinase inhibitor; acute lymphoblastic leukemia; adult; age distribution; aged; allogeneic stem cell transplantation; allotransplantation; Article; cancer chemotherapy; comparative study; female; first-line treatment; human; human cell; human tissue; intensive care; leukemia remission; long term survival; major clinical study; male; mortality; overall survival; Philadelphia 1 chromosome; recurrence free survival; reduced intensity chemotherapy; retrospective study; therapy effect; treatment outcome; adverse event; allotransplantation; B cell acute lymphoblastic leukemia; clinical trial; drug therapy; hematopoietic stem cell transplantation; middle aged; multicenter study; Philadelphia 1 chromosome; South Korea; therapy; time factor | English | 2025 | 2025-01 | 10.3904/kjim.2024.227 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Screening and diagnosis of atrial fibrillation using wearable devices | In recent years, the development and use of various devices for the screening of atrial fibrillation (AF) have significantly increased. Such devices include 12-lead electrocardiogram (ECG), photoplethysmography systems, and single-lead ECG and ECG patches. This review outlines several studies that have focused on the feasibility and efficacy of such devices for AF screening, and summarizes the risks and benefits involved in the initiation of anticoagulant therapy after early detection of AF. We also describe several ongoing trials on unresolved issues associated with AF screening. Overall, this review provides a comprehensive summary of the current state of AF screening and its implications for patient care. | Park, Yoon Jung; Bae, Myung Hwan | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Cardiol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med,Div Cardiol, 130 Dongdeok Ro, Daegu 41944, South Korea | 57216539556; 36607356800 | bmh0325@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 2.22 | 2025-05-07 | 1 | 1 | Atrial fibrillation; Wearable devices; Anticoagulants; Stroke; Risk assessment | NATIONAL HEART; STROKE; METAANALYSIS; FEASIBILITY; GUIDELINES; MANAGEMENT; EPISODES; SOCIETY; RISK; ECG | Anticoagulants; Atrial fibrillation; Risk assessmen; Stroke; Wearable devices | Anticoagulants; Atrial Fibrillation; Electrocardiography; Equipment Design; Heart Rate; Humans; Photoplethysmography; Predictive Value of Tests; Wearable Electronic Devices; anticoagulant agent; anticoagulant agent; 12 lead electrocardiogram; atrial fibrillation; cerebrovascular accident; clinical trial (topic); early diagnosis; electrocardiogram; electrocardiogram patch; feasibility study; human; Review; risk assessment; screening test; single lead electrocardiogram; atrial fibrillation; devices; diagnosis; electrocardiography; equipment design; heart rate; pathophysiology; photoelectric plethysmography; predictive value; wearable computer | English | 2025 | 2025-01 | 10.3904/kjim.2023.521 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The characteristics of Korean elderly multiple myeloma patients aged 80 years or over | Background/Aims: Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed. Methods: This retrospective multicenter study was conducted to investigate the clinical characteristics, treatment patterns, and survival outcomes of patients aged 80 years or over who were newly diagnosed with MM at five academic hospitals in Daegu, Korea, between 2010 and 2019. Results: A total of 127 patients with a median age of 83 years (range, 80-93 yr) were enrolled: 52 (40.9%) with Eastern Cooperative Oncology Group Performance Status (ECOG PS) > 2, 84 (66.1%) with International Staging System (ISS) stage III disease, and 93 (73.2%) with a Charlson comorbidity index (CCI) > 4. Chemotherapy was administered to 86 patients (67.7%). The median overall survival was 9.3 months. Overall survival was significantly associated with ECOG PS > 2 (HR 2.26, 95% CI 1.43-3.59), ISS stage III (HR 1.99, 95% CI 1.18-3.34), and chemotherapy (HR 0.34, 95% CI 0.21-0.55). There was no statistically significant difference in event-free survival according to the type of anti-myeloma chemotherapy administered. The early mortality (EM) rate was 28.3%. Conclusions: Even in patients with MM aged 80 years or over, chemotherapy can result in better survival outcomes than supportive care. Patients aged >= 80 years should not be excluded from chemotherapy based on age alone. However, reducing EM in elderly patients with newly diagnosed MM remains challenging. | Lee, Sang Hwan; Cho, Hee-Jeong; Moon, Joon Ho; Jung, Ji Yoon; Kim, Min Kyoung; Heo, Mi Hwa; Do, Young Rok; Hwang, Yunhwi; Bae, Sung Hwa | Daegu Fatima Hosp, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; Yeungnam Univ, Med Ctr, Dept Hematol Oncol, Daegu, South Korea; Keimyung Univ, Dept Hematol Oncol, Dongsan Med Ctr, Daegu, South Korea; Daegu Catholic Univ, Dept Hematol Oncol, Med Ctr, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea | 59513481500; 57216754907; 56568642700; 57390809300; 57206000629; 57217563491; 8960168300; 59513481600; 56545017400 | sunghwa@cu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 40 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-05-07 | 0 | 0 | Multiple myeloma; Elderly; Chemotherapy | INTERNATIONAL STAGING SYSTEM; EARLY MORTALITY; REAL-WORLD; GERIATRIC ASSESSMENT; CLINICAL-FEATURES; CRITERIA; SURVIVAL; OUTCOMES | Chemotherapy; Elderly; Multiple myeloma | Age Factors; Aged, 80 and over; Female; Humans; Male; Multiple Myeloma; Neoplasm Staging; Republic of Korea; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; bortezomib; cyclophosphamide; lenalidomide; melphalan; prednisone; aged; aging; Article; cancer chemotherapy; cancer staging; Charlson Comorbidity Index; ECOG Performance Status; event free survival; female; human; International Staging System; Korean (people); major clinical study; male; mortality rate; multiple myeloma; overall survival; retrospective study; university hospital; very elderly; age; clinical trial; diagnosis; drug therapy; epidemiology; mortality; multicenter study; multiple myeloma; risk factor; South Korea; therapy; time factor; treatment outcome | English | 2025 | 2025-01 | 10.3904/kjim.2024.041 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers | Clinical biomarkers are crucial for diagnosing and predicting outcomes in patients with traumatic brain injury (TBI). In this study, we performed an unbiased analysis of plasma proteins in acute TBI patients using bead-based multiplex assays and identified a strong positive correlation between LCN2 and IL-6 levels. Based on these findings, we hypothesized that LCN2 and IL-6 are closely related circulating biomarkers for TBI. Our previous and current studies demonstrate that the expression of LCN2, IL-6, and its receptors is upregulated in patients with chronic traumatic encephalopathy, in mouse models of traumatic and ischemic injury, and in an in vitro scratch injury model. Lcn2-deficiency reduced the injury-induced expression of IL-6 and its receptors in both animal and scratch injury models. These results suggest an augmented LCN2-dependent IL-6 signaling in the injured brain. As both LCN2 and IL-6 are secreted proinflammatory mediators, we further explored the possibility of cross-regulation between LCN2 and IL-6. In cultured glial cells, treatment with recombinant LCN2 protein enhanced the microglial expression of IL-6, while IL-6 protein treatment increased astrocytic LCN2 expression. Moreover, IL-6 expression and release were elevated in LCN2-overexpressing transgenic mice. Mechanistically, IL-6 enhanced astrocytic LCN2 expression through STAT3 signaling, while LCN2 upregulated microglial IL-6 expression through the NF-kappa B pathway. Taken together, our results suggest an important role of the LCN2-IL6 axis in amplifying neuroinflammation through a positive feedback loop in secondary brain injury conditions. Finally, this study implies the utility of LCN2 and IL-6 as closely related biomarkers for TBI diagnosis and prognosis. | Kim, Jae-Hong; Jeong, Han-Gil; Hyeon, Seung Jae; Park, Uiyeol; Oh, Won-Jong; Hwang, Junmo; Lim, Hyun-Ho; Ko, Pan-Woo; Lee, Ho-Won; Lee, Won-Ha; Ryu, Hoon; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Korea 21 Four KNU Convergence Educ Program B, Daegu 41940, South Korea; Seoul Natl Univ, Coll Med, Dept Neurosurg & Neurol, Div Neurocrit Care,Bundang Hosp, Seongnam 13620, South Korea; Korea Inst Sci & Technol, Brain Sci Inst, Ctr Brain Disorders, Seoul 02792, South Korea; Korea Brain Res Inst KBRI, Neurovasc Unit Res Grp, Daegu 41068, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Brain & Cognit Sci, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu 41404, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Vet Affairs Boston Healthcare Syst, Boston, MA 02130 USA; Boston Univ, Alzheimers Dis Ctr, Boston, MA 02118 USA; Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA | Lee, Ho Won/AAE-7526-2022; Ryu, Hoon/MCJ-9411-2025; Jeong, Han-Gil/K-4171-2019; Lim, Hyun-Ho/IZD-6808-2023 | 55926599800; 58378056700; 57191974819; 57580906700; 8588864800; 57715408200; 7403095325; 55543341200; 35337240700; 57205609794; 7202277209; 7005114595 | hoonryu@kist.re.kr; ksuk@knu.ac.kr; | EXPERIMENTAL NEUROLOGY | EXP NEUROL | 0014-4886 | 1090-2430 | 385 | SCIE | NEUROSCIENCES | 2024 | 4.2 | 23.4 | 0 | 2025-05-07 | 0 | 0 | LCN2; IL-6; Traumatic brain injury; Neuroinflammation; Biomarker | ASTROCYTES; INTERLEUKIN-6; PROTEIN; GFAP; ENCEPHALOPATHY; POLARIZATION; ACTIVATION; EXPRESSION; CYTOKINE; PATHWAY | Biomarker; IL-6; LCN2; Neuroinflammation; Traumatic brain injury | Adult; Animals; Biomarkers; Brain Injuries, Traumatic; Female; Humans; Interleukin-6; Lipocalin-2; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; biological marker; immunoglobulin enhancer binding protein; interleukin 6; neutrophil gelatinase associated lipocalin; recombinant protein; STAT3 protein; biological marker; interleukin 6; LCN2 protein, human; Lcn2 protein, mouse; neutrophil gelatinase associated lipocalin; adult; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; chronic traumatic encephalopathy; clinical article; controlled study; correlation analysis; female; glial cell culture; human; human tissue; hypoxic ischemic encephalopathy; in vitro study; Lcn2 gene; male; middle aged; mouse; nervous system inflammation; NF kB signaling; nonhuman; prediction; prognosis; protein blood level; protein expression; protein function; receptor cross-talk; transgenic mouse; traumatic brain injury; treatment outcome; upregulation; animal; C57BL mouse; genetics; knockout mouse; metabolism; traumatic brain injury | English | 2025 | 2025-03 | 10.1016/j.expneurol.2024.115092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of pilates on the physical and mental health of drug-dependent individuals - a randomized controlled trial | Objective Drug-dependent individuals often face severe physical and mental health impairments, necessitating safe and adaptable rehabilitation strategies. This study aims to investigate the effects of Pilates exercise on the physical and mental health of drug-dependent individuals. Specifically, the study seeks to evaluate changes in body composition, physical fitness, blood biochemistry, and psychological outcomes following a structured Pilates intervention. Methods This study was conducted as a double-blind, parallel-group, randomized controlled trial. A total of 43 substance-dependent individuals were recruited from the Judong Drug Rehabilitation Center and randomly assigned to either the Pilates intervention group (n = 22) or the control group (n = 21). The experimental group underwent Pilates program of two weekly sessions for 24 weeks, while the control group received conventional rehabilitation. We assessed physical and mental health indicators at baseline, 12, and 24 weeks. Repeated measures analysis of variance was employed to discern inter-group differences, and Spearman correlation analysis was applied to assess the relationship between fluctuations in scores on anxiety and depression scales and those of associated physiological metrics. Results After 24 weeks of Pilates intervention, the intervention group showed significant improvements (p < 0.05) in body fat percentage, skeletal muscle mass, sit-and-reach distance, push-up performance, one-leg standing with eyes closed, vital capacity, white blood cell count, and neutrophil count. Psychological assessments revealed significant differences in scores on the Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) between the experimental and control groups (p < 0.01), with more pronounced effects in the experimental group. Additionally, changes in SDS scores were correlated with changes in sit-and-reach distance (r = -0.657, p < 0.001), one-leg standing with eyes closed (r = -0.734, p < 0.001), and vital capacity (r = -0.490, p = 0.001). Changes in SAS scores were correlated with changes in the neutrophil-to-lymphocyte ratio (r = -0.304, p = 0.048), platelet-to-lymphocyte ratio (r = -0.320, p = 0.037), sit-and-reach distance (r = -0.595, p < 0.001), one-leg standing with eyes closed (r = -0.704, p < 0.001), and vital capacity (r = -0.472, p = 0.001). Conclusion The Pilates intervention significantly enhanced participants' physical attributes-body composition, strength, endurance, flexibility, balance, lung function, and immune response-while alleviating anxiety and depression. Correlations were identified between mental health improvements and physical gains, indicating that tailored exercise, informed by ongoing health monitoring, could optimize drug rehabilitation outcomes. | Ji, Feng; Zhou, Ensong; Zhao, Peng; Chen, Xinliang; Wang, Hui; Zhong, Jiabin; Zhang, Yi; Lu, Yunhang; Zhang, Qing | Soochow Univ, Sch Phys Educ & Sports Sci, Suzhou 215021, Peoples R China; Judong Compulsory Isolat Drug Rehabil Ctr, Zhenjiang 212400, Jiangsu, Peoples R China; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea | 59502837000; 59923285700; 59486589900; 59486301900; 59923186300; 59923395300; 59923711700; 57262012200; 57189700158 | yunhanglu@suda.edu.cn; zhangqing@suda.edu.cn; | BMC PSYCHIATRY | BMC PSYCHIATRY | 1471-244X | 25 | 1 | SCIE | PSYCHIATRY | 2024 | 3.6 | 23.4 | 0 | 2025-06-11 | 0 | 0 | Pilates; Exercise Intervention; Physical and Mental Health; Drug Addiction; Rehabilitation | SUBSTANCE USE DISORDERS; TO-LYMPHOCYTE RATIO; AEROBIC EXERCISE; CORE STABILITY; ANXIETY; DEPRESSION; INFLAMMATION; BALANCE; BLOOD; YOGA | Drug Addiction; Exercise Intervention; Physical and Mental Health; Pilates; Rehabilitation | Adult; Anxiety; Body Composition; Depression; Double-Blind Method; Exercise Movement Techniques; Female; Humans; Male; Mental Health; Middle Aged; Physical Fitness; Substance-Related Disorders; hemoglobin; methamphetamine; adult; anxiety; Article; bioelectrical impedance analysis; blood biochemistry; blood cell count; body composition; body fat; body fat percentage; body mass; caloric intake; CCMD-3; controlled study; depression; diastolic blood pressure; dietary supplement; double blind procedure; drug dependence; drug dependence treatment; endurance; exercise intensity; fat free mass; female; fitness; grip strength; hematocrit; human; human experiment; immune response; leukocyte count; lung capacity; lung function; male; mean corpuscular hemoglobin; mean corpuscular hemoglobin concentration; mean corpuscular volume; mean platelet volume; mental health; muscle mass; neutrophil count; neutrophil lymphocyte ratio; outcome assessment; physical functioning; pilates; platelet count; platelet lymphocyte ratio; protein content; psychologic assessment; randomized controlled trial; red blood cell distribution width; resting heart rate; scoring system; Self-rating Anxiety Scale; Self-rating Depression Scale; systolic blood pressure; training; vital capacity; waist hip ratio; blood; drug dependence; fitness; kinesiotherapy; middle aged; pathophysiology; physiology; procedures; psychology; rehabilitation | English | 2025 | 2025-06-02 | 10.1186/s12888-025-07008-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Hematologic and molecular responses to ropeginterferon alfa-2b therapy of polycythemia vera: 48-week results from a prospective study | To prevent thrombosis in patients with polycythemia vera (PV), achieving a complete hematologic response (CHR) is highly recommended in practice. In addition, a reduced JAK2 V617F mutation burden is expected to have a disease-modifying effect, and its molecular response (MR) is currently of significant interest. This study aimed to assess the association between CHR and MR in patients with PV following treatment with ropeginterferon alfa-2b. This phase 2, single-arm, open-label, investigator-initiated trial was conducted at 16 sites in South Korea. Ninety-nine patients were treated with ropeginterferon alfa-2b subcutaneously every 2 weeks, at doses of 250 mu g (week 1), 350 mu g (week 3), and 500 mu g (week 5), until week 48. CHRs were 27% (25/94), 46% (40/87), 56% (47/84), and 63% (51/81) at 12, 24, 36, and 48 weeks, respectively. The MR rates were 32% (28/88), 36% (29/81), 49% (38/77), and 57% (42/74) at 12, 24, 36, and 48 weeks, respectively. The Phi Coefficient for the association between CHR and MR was 0.6146 (p < .0001) at 48 weeks. In the subgroup analysis, patients with hydroxyurea resistance or intolerance, and those who were hydroxyurea-na & iuml;ve, had similar results in terms of the CHR. In conclusion, CHR and MR were observed to be associated in patients with PV treated with ropeginterferon. | Yoon, Seug Yun; Yoon, Sung-Soo; Yang, Deok-Hwan; Lee, Gyeong-Won; Sohn, Sang Kyun; Shin, Ho-Jin; Bae, Sung Hwa; Choi, Chul Won; Choi, Eun-Ji; Cheong, June-Won; Bang, Soo-Mee; Park, Joon Seong; Oh, Suk Joong; Park, Yong; Park, Young Hoon; Lee, Sung-Eun | Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Hematol & Med Oncol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Internal Med, Gwangju, Jeollanam Do, South Korea; Gyeongsang Natl Univ, Coll Med, Gyeongsang Natl Univ Hosp,Inst Hlth Sci, Div Hematol & Oncol,Dept Internal Med, Jinju, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; Pusan Natl Univ Hosp, Dept Hematol Oncol, Busan, South Korea; Daegu Catholic Univ, Dept Internal Med, Div Hematol Oncol, Sch Med,Daegu Catholic Univ Hosp, Daegu, South Korea; Korea Univ, Guro Hosp, Div Oncol & Hematol, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hematol, Seoul, South Korea; Yonsei Univ, Coll Med, Severance Hosp,Dept Internal Med, Div Hematol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Coll Med, Seongnam, South Korea; Ajou Univ, Sch Med, Dept Hematol Oncol, Suwon, South Korea; Hanyang Univ, Dept Oncol, Asan Med Ctr, Seoul 138736, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea; Ewha Womans Univ, Mokdong Hosp, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Hematol, 222 Banpodae Ro, Seoul 06591, South Korea | Lee, SangHun/GPW-6306-2022 | 57204102441; 59653630900; 8701758000; 59700466900; 13310226800; 16239868400; 56545017400; 13907063000; 57358266500; 7004933294; 7102038069; 57685470700; 59699687100; 7405373234; 57212764446; 59664064100 | lee86@catholic.ac.kr; | INTERNATIONAL JOURNAL OF CANCER | INT J CANCER | 0020-7136 | 1097-0215 | 157 | 3 | SCIE | ONCOLOGY | 2024 | 4.7 | 23.5 | 0 | 2025-05-07 | 1 | 1 | association; CHR; MR; polycythemia vera; ropeginterferon alfa-2b | ALLELE BURDEN; JAK2 | association; CHR; MR; polycythemia vera; ropeginterferon alfa-2b | Adult; Aged; Female; Humans; Interferon alpha-2; Interferon-alpha; Janus Kinase 2; Male; Middle Aged; Mutation; Polycythemia Vera; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Treatment Outcome; hemoglobin; hydroxyurea; ropeginterferon alpha2b; alpha interferon; alpha2 interferon; JAK2 protein, human; Janus kinase 2; macrogol; peginterferon alpha2b; recombinant protein; absolute neutrophil count; adult; aged; anemia; Article; clinical chemistry; drug efficacy; drug safety; ECOG Performance Status; electrocardiography; fatigue; female; gene mutation; hematocrit; hematology; human; hypertension; leukocyte count; major clinical study; male; phase 2 clinical trial; platelet count; polycythemia vera; prospective study; quality of life; survival analysis; thorax radiography; thrombosis; blood; clinical trial; drug therapy; genetics; middle aged; multicenter study; mutation; treatment outcome | English | 2025 | 2025-08-01 | 10.1002/ijc.35411 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Factors predicting early recurrence in patients with unresectable stage III non-small cell lung cancer on durvalumab consolidation after chemoradiotherapy | Background: Durvalumab consolidation after concurrent chemoradiotherapy (CCRT) is the present standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC). However, some patients experience early recurrence. This study sought risk factors for early recurrence during durvalumab consolidation. Methods: This retrospective multicenter study was conducted between September 2017 and September 2022. We categorized patients into early and non-early recurrence groups. Early recurrence was defined as recurrence within 6 months after the first dose of durvalumab. Results: Of the 222 patients, 40 (18.0%) experienced early recurrence and 182 (82.0%) experienced non-early recurrence. The former group was younger than the latter group (P=0.02). Patients exhibiting lower-level programmed cell death-ligand 1 (PD-L1) expression were more likely to experience early recurrence (P=0.02). Stage IIIC patients tended to experience more early recurrence than stage IIIA/IIIB patients (P=0.055). Multivariate analyses revealed that older age [odds ratio (OR), 0.945; 95% confidence interval (CI): 0.902-0.991; P=0.02] and PD-L1 level >= 50% (OR, 0.303; 95% CI: 0.125-0.736; P=0.008) protected against early recurrence in NSCLC patients on durvalumab consolidation. Median overall survival was significantly longer in the non-early recurrence group than in the early recurrence group (non-evaluable vs. 11.0 months, respectively; P<0.001). Conclusions: Younger age and lower PD-L1 expression predicted early recurrence during durvalumab consolidation after CCRT. Careful follow-up of such patients is essential. | Park, Ji Eun; Kim, Chanmi; Choi, Sun Ha; Jang, Jong Geol; Hong, Kyung Soo; Kwon, Yong Shik; Choi, Keum-Ju; Eom, Jung Seop; Kim, Saerom; Seol, Hee Yun; Kim, Jehun; Kim, Insu; Park, Jin Han; Kim, Tae Hoon; Ahn, June Hong | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, 170 Hyeonchung Ro, Daegu 42415, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Div Pulmonol,Resp Ctr, Daegu, South Korea; Daegu Catholic Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ, Sch Med, Yangsan Hosp, Dept Internal Med,Div Pulm & Crit Care Med, Yangsan, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Inje Univ, Coll Med, Dept Internal Med, Busan, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Chang Won, South Korea | Ahn, June/AAB-3093-2019 | 57195437358; 59667713700; 57199723585; 56645456400; 56645558700; 57203804743; 58945401100; 57201262394; 57490278900; 57208402180; 57191899861; 57191965736; 57043777100; 57188703626; 56645445800 | fireajh@gmail.com; | TRANSLATIONAL LUNG CANCER RESEARCH | TRANSL LUNG CANCER R | 2218-6751 | 2226-4477 | 14 | 4 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2024 | 3.5 | 23.6 | 0 | 2025-05-07 | 0 | 0 | Chemoradiotherapy; durvalumab; early recurrence; non-small cell lung cancer (NSCLC) | CHEMOTHERAPY | Chemoradiotherapy; durvalumab; early recurrence; non-small cell lung cancer (NSCLC) | antineoplastic agent; carboplatin; cisplatin; durvalumab; etoposide; paclitaxel; pemetrexed; programmed death 1 ligand 1; adult; age; aged; Article; cancer combination chemotherapy; cancer immunotherapy; cancer recurrence; cancer staging; cancer survival; chemoradiotherapy; consolidation chemotherapy; female; human; inoperable cancer; large cell neuroendocrine carcinoma; lung adenocarcinoma; major clinical study; male; median survival time; monoclonal antibody therapy; multicenter study; non small cell lung cancer; observational study; overall survival; protein expression; recurrence risk; recurrent disease; retrospective study; risk factor; squamous cell lung carcinoma; treatment response | English | 2025 | 2025-04-30 | 10.21037/tlcr-2024-1112 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Adhesion performance of demethylated hardwood kraft lignin phenol-formaldehyde adhesive for wood bonding | Hardwood kraft lignin (HKL) is a by-product of kraft pulping, and has potential application as a renewable and bio-based material, thereby reducing the reliance on fossil-based materials. However, the steric hindrance and low reactivity of the methoxy groups of HKL limit its potential for generating a thermosetting polymer network in lignin-based wood adhesives. Hence, the present study examines the adhesion performance of lignin phenol-formaldehyde (LPF) resins synthesized using demethylated hardwood kraft lignin (DHKL) for plywood bonding. By decreasing the methoxy content of HKL, the demethylation process enhances its reactivity with PF resins. The demethylation reaction is studied using various methods such as ATR-FTIR,1H NMR,31P NMR, DSC, and TGA. Both spectroscopic and thermal analyses confirm the successful demethylation of HKL by sodium sulfite. Subsequently, LPF adhesives with various DHKL substitution levels (10%, 20%, 30%, and 50% w/w phenol) are evaluated for their resin properties and adhesion performance with plywood. In particular, the LPF adhesive with 10% DHKL exhibits an improved tensile shear strength of 1.58 ± 0.22 MPa compared to 1.2 ± 0.2 MPa for the reference PF resin. Notably, both of these values exceed the requirements of the Korean National Standard (0.6 MPa) and the European Norm (EN) 314-2 (1 MPa). These results demonstrate that the incorporation of DHKL is a promising approach to the synthesis of LPF resins, offering eco-friendly adhesives for wood bonding with high adhesion performance. © 2025 Informa UK Limited, trading as Taylor & Francis Group. | Ghahri, Saman; Park, Byung-Dae | Department of Wood and Paper Science, Kyungpook National University, Daegu, South Korea; Department of Wood and Paper Science, Kyungpook National University, Daegu, South Korea | 53063443000; 59874304100 | byungdae@knu.ac.kr; | Journal of Adhesion Science and Technology | J ADHES SCI TECHNOL | 0169-4243 | 1568-5616 | SCIE | ENGINEERING, CHEMICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;MECHANICS | 2024 | 3.7 | 23.7 | 0 | adhesion; crosslinking; Hardwood kraft lignin demethylation; PF resins | Adhesives; Bonding; Crosslinking; Formaldehyde; Hardwoods; Kraft process; Kraft pulp; Lignin; Plywood; Resins; Shear strength; Tensile strength; Thermoanalysis; Thermosets; Adhesion performance; Adhesives for wood; Demethylation; Hardwood kraft; Hardwood kraft lignin demethylation; Kraft lignin; Lignin-phenol-formaldehyde; PF resin; Phenol-formaldehyde adhesives; Wood bonding; Adhesion; Sodium sulfite | English | Article in press | 2025 | 10.1080/01694243.2025.2509746 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | A hydrogel-ionic polymer blend for humidity-insensitive ion gradient driven electricity generation | Sustainable means of providing electricity are of paramount importance for next-generation electronic devices. Recently, exploiting ion concentration gradients has been suggested a viable method to generate electricity. When a cationic polymer and an anionic polymer come into contact, the freely mobile anions and cations in the charged polymers migrate down the concentration gradient producing electrical potential. In this work, we show that by blending the charged polymers in a hydrogel, the electrical potential can be sustained for an extended period of time providing opportunities for reliable energy harvesting. Agarose blocks blended with poly(diallyldimethyl ammonium chloride) (PDDA) and with anionic poly(sodium 4-styrenesulfonate) (PSS) are stacked together to allow the diffusion of Na+ and Cl- ions down the concentration gradients and produce electricity. The high-moisture absorption and retainment capability of agarose facilitate the diffusion of the ions, and accordingly, a peak open-circuit voltage (VOC) and peak short-circuit current (ISC) of similar to 120 mV and similar to 48 mu A are produced, respectively. These values can be increased to 426 mV and 89.2 mu A when connected serially or in parallel. Both ionic polymer concentration and gel thickness are found to strongly influence the VOC and ISC while the interfacial contact area and relative humidity do not affect the energy harvesting performance. Enabled by the high-moisture absorption capability and retainment of the agarose hydrogel, the VOC can be sustained for over 100 h with no change. | Kim, Byeunggon; Faramarzi, Paniz; Kim, Jeong Hyo; Jang, Wonik; Yoo, Youngmin; You, Jae Bem | North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27606 USA; Kyungpook Natl Univ, Dept Energy Convergence & Climate Change, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, Green Carbon Res Ctr, Daejeon 34114, South Korea; Chungnam Natl Univ, Dept Chem Engn & Appl Chem, Daejeon 34134, South Korea | You, Jae/C-6211-2019; You, Jae Bem/C-6211-2019; Kim, Byeunggon/LXW-3860-2024 | 57850996900; 58089703600; 59654657400; 58926849500; 55642500700; 55619455300 | ymyoo@krict.re.kr; jb.you@cnu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 13 | 13 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 5.1 | 23.8 | 0 | 2025-05-07 | 0 | 0 | NANOFLUIDIC MEMBRANES; DEVICES | Elastomers; Negative ions; Polymer blends; Positive ions; Surface discharges; Agarose; Charged polymers; Concentration- gradients; Electrical potential; Electricity-generation; Gradient-driven; High moisture; Ion gradients; Ionic polymer; Moisture absorption; Open circuit voltage | English | 2025 | 2025-03-27 | 10.1039/d4tc04885g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Bio-derived graphitic carbon microspheres: A green approach for high-frequency microwave absorption | Bio-derived carbon materials have emerged as a sustainable alternative to non-renewable petroleum-based carbon sources, thanks to their reproducibility and environmental benefits. There is a strong demand for developing and efficiently utilizing carbon-based microwave absorbing materials (MAMs) that are lightweight, require low filler loading, and offer broadband absorption for electromagnetic wave (EM) applications. In this context, we successfully synthesized uniform carbon microspheres from the natural precursor turpentine oil using the chemical vapor deposition (CVD) technique at various temperatures. The sample prepared at 1000 degrees C (GC-1000) exhibited a uniform carbon microsphere morphology, as confirmed by XRD and Raman spectroscopy, and demonstrated extremely good microwave absorption properties. With a low filler loading of just 5 wt%, the GC-1000 sample achieved a minimum reflection loss (RL) of -39.77 dB at 10.21 GHz and an effective absorption bandwidth of 2.51 GHz at a matching thickness of only 2.8 mm. Additionally, this sample showed a total shielding effectiveness (SET) of -44.74 dB, surpassing the threshold required for commercial applications. The graphitic phase formation, confirmed by XRD and Raman analysis, acts as a conductive trap for electromagnetic radiation, and the high surface area of the uniform carbon microspheres facilitates multiple internal reflections, enhancing overall microwave absorption performance in the X-band region. Our lightweight, durable, bioderived carbon microspheres, synthesized through a cost-effective and scalable process, show significant potential for EM wave absorption in military and electromagnetic compatibility (EMC) devices. | Sutar, Rohit B.; Kulkarni, Gopal K.; Koli, Rohit R.; Dhas, Suprimkumar D.; Velhal, Ninad B.; Rajpure, Keshav Y.; Puri, Vijaya R.; Yadav, Jyotiprakash B. | Shivaji Univ, Vacuum Tech & Thin Film Lab, USIC, Kolhapur 416004, Maharashtra, India; Shivaji Univ, Dept Phys, Thick & Thin Film Device Lab, Kolhapur 416004, Maharashtra, India; Kyung Hee Univ, Inst Wearable Convergence Elect, Dept Elect Engn, 1732 Deogyeong Daero, Yongin 17104, South Korea; Kyungpook Natl Univ, Dept Energy Chem Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Shivaji Univ, Dept Phys, Electrochem Mat Lab, Kolhapur 416 004, Maharashtra, India | Rajpure, Keshav/AAG-3257-2019; Dhas, Suprimkumar/GVT-1027-2022; Kulkarni- Ruikar, Deepti/AAS-6656-2021; Velhal, Ninad/O-2578-2014 | 57223274003; 57189299882; 57193809845; 57218163388; 56116686900; 6701673471; 7103237565; 16199906100 | gopalkulkarni90@gmail.com; jbyadavphy@gmail.com; | DIAMOND AND RELATED MATERIALS | DIAM RELAT MATER | 0925-9635 | 1879-0062 | 151 | SCIE | MATERIALS SCIENCE, COATINGS & FILMS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 5.1 | 23.8 | 2.74 | 2025-05-07 | 2 | 3 | Carbon microspheres; Microwave absorption; Reflection loss; EMI shielding; Relative permittivity | INTERFERENCE SHIELDING EFFECTIVENESS; REDUCED GRAPHENE OXIDE; TEMPERATURE; PERFORMANCE; SPHERES; ABSORBER; NANOCOMPOSITES; COMPOSITES; DESIGN; FOAM | Carbon microspheres; EMI shielding; Microwave absorption; Reflection loss; Relative permittivity | Carbon microspheres; Electromagnetics; EMI shielding; Filler loading; Graphitic carbons; High frequency HF; Microwave absorption; Reflection loss; Relative permittivity; Synthesised; Microspheres | English | 2025 | 2025-01 | 10.1016/j.diamond.2024.111836 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optimized electrical and optical properties of Ag micro-meshes by self-generated cracks for transparent electrodes | Transparent conductive electrodes (TCEs) are essential components in the development of various transparent devices. In this study, a Ag micro-mesh network was investigated as an indium-free, non-rigid TCE for applications in flexible devices or solar cells. Instead of a complex and expensive process, such as photolithography with a shadow mask to fabricate a micro-grid, the Ag micro-mesh electrode was fabricated using self-generated cracked templates. The structure of the metallic network was controlled by varying the spin-coating speed and silica solution concentration so that a highly interconnected metallic network can be obtained. Using these techniques, various widths and densities of cracks were obtained and analyzed to compare their optical and electrical properties. Finally, the figure of merit (FoM) for the transparent electrode was calculated based on the measurement results, which revealed that the Ag micro-mesh electrode exhibited the highest performance when the crack widths were mostly distributed in the range of 1-2 mu m, regardless of the fabrication conditions. The optimum Ag micro-mesh electrode achieved 88% transmittance at 550 nm wavelength and exhibited 20 Omega sq-1 sheet resistance. These optical and electrical properties are comparable to those of indium-doped tin oxide (ITO) and/or aluminum-doped zinc oxide (AZO) that are used as TCE materials. | Jo, Seung Taek; Shin, Jin Wook; Kim, Min-Soo; Park, Sang-Shik; Commerell, Walter; Yoo, Hyesun; Hwang, Jinyoung; Roh, Jong Wook | Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Gyeongsangbuk Do 37224, South Korea; TH Ulm THU, Inst Energy & Drive Technol, D-89081 Ulm, Germany; Kyungpook Natl Univ, Reg Leading Res Ctr RLRC Smart Energy Syst, Gyeongsangbuk Do 37224, South Korea; Korea Aerosp Univ, Sch Elect & Informat Engn, Goyang Si 10540, Gyeonggi Do, South Korea | 59177187500; 59178094400; 58608961200; 7501833211; 56431049800; 57211941826; 56898317100; 25638796100 | vorahsun@gmail.com; jinhwang@kau.ac.ck; jw.roh@knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 13 | 18 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 5.1 | 23.8 | 0 | 2025-05-07 | 0 | 0 | NETWORK; THIN | Aluminum coatings; Density (optical); Indium; Indium compounds; Optical depth; Zinc coatings; Electrical and optical properties; Indium-free; Mesh electrodes; MeshNetworks; Metallics; Micro mesh; Optical and electrical properties; Transparent conductive electrodes; Transparent devices; Transparent electrode; Transparent electrodes | English | 2025 | 2025-05-08 | 10.1039/d4tc04471a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Review | Strategic design of emerging (K,Na)NbO3-based perovskites for high-performance piezocatalysis and photo-piezocatalysis | As a leading Pb-free perovskite material (ABO3-type), potassium sodium niobate (K,Na)NbO3 (KNN)-based ferroelectrics/piezoelectrics have been widely used in electronics, energy conversion, and storage due to their exceptional ability to interconvert mechanical and electrical energies. Beyond traditional applications, the piezoelectric potential generated by mechanical strain or stress modifies their energy band structures and facilitates charge carrier separation and transport, drawing increasing attention in emerging fields such as piezocatalysis and photo-piezocatalysis. With excellent piezoelectric properties, chemical/thermal stability, and strain-tuning capability, KNN-based materials show great promise for high-performance piezocatalytic applications. Coupling KNN with semiconductors exhibiting strong optical absorption to form heterojunctions further boosts performance by suppressing electron-hole recombination and promoting directed charge transfer, which is crucial for photo-piezocatalysis. The flexibility of KNN's perovskite structures also allows for modifications in chemical composition and crystal structure, enabling diverse design strategies such as defect engineering, phase boundary engineering, morphology control, and heterojunction formation. This review comprehensively explores the recent advancements in KNN-based piezocatalysis and photo-piezocatalysis, starting with an overview of their crystal structures and intrinsic properties. It then explores the role of piezoelectric potential in charge carrier dynamics and catalytic activity, followed by strategic design approaches to optimize efficiency in environmental remediation and energy conversion. Finally, the review addresses current challenges and future research directions aimed at advancing sustainable solutions using KNN-based materials in these applications. | Park, Seonhwa; Jeong, Hui Yong; Kim, Seokhwan; Peddigari, Mahesh; Hwang, Geon-Tae; Moon, Geon Dae; Roh, Jong Wook; Min, Yuho | Kyungpook Natl Univ, Reg Leading Res Ctr Smart Energy Syst, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Innovat Semicond Educ & Res Ctr Future Mobil, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Automot Parts & Mat, 80 Daehakro, Daegu 41566, South Korea; Indian Inst Technol Hyderabad, Dept Phys, Kandi 502284, Telangana, India; Pukyong Natl Univ, Dept Mat Sci & Engn, Busan 48513, South Korea; Korea Inst Ind Technol, Dongnam Reg Div, Busan 46938, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Sangju 37224, South Korea | Min, Yuho/AAA-1287-2020 | jw.roh@knu.ac.kr; yuhomin@knu.ac.kr; | NANOSCALE | NANOSCALE | 2040-3364 | 2040-3372 | 17 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2024 | 5.1 | 23.8 | 2 | S-SCHEME HETEROJUNCTION; PIEZOELECTRIC PROPERTIES; GIANT PIEZOELECTRICITY; PHASE-BOUNDARY; VISIBLE-LIGHT; PHOTOCATALYST; DEGRADATION; TEMPERATURE; ENERGY; SEMICONDUCTOR | English | 2025 | 2025-02-06 | 10.1039/d4nr04415k | 바로가기 | 바로가기 | 바로가기 |
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