2025 연구성과 (71 / 151)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Molecular Level Understanding of Amine Structural Variations on Diaminodiphenyl Sulfone to Thermomechanical Characteristics in Bifunctional Epoxy Resin: Molecular Dynamics Simulation Approach | Epoxy-based composite materials, widely used in various industries such as coatings, adhesives, aerospace, electronics, and biomedical engineering, remain a topic of global interest due to their varying characteristics based on the base resin and curing agents used. This paper employs molecular dynamics simulation to examine the thermal and mechanical properties, as well as molecular behaviors, of epoxy systems cured with diglycidyl ether of bisphenol F as the base resin and aromatic amine curing agents, specifically the meta structure of 3,3 '-diaminodiphenyl sulfone (3,3 '-DDS) and the para structure of 4,4 '-diaminodiphenyl sulfone (4,4 '-DDS). The 3,3 '-DDS system demonstrated a greater density and Young's modulus than the 4,4 '-DDS system. This tendency was analyzed based on differences in molecular fractional free volume and cohesive energy density (CED). The 4,4 '-DDS system exhibits a higher glass transition temperature (Tg) compared to the 3,3 '-DDS system, with values of 406.36 K and 431.22 K, respectively. To understand this behavior, we examined atomic-scale displacements at Tg through mean squared displacement analysis, which revealed that the onset of molecular motion occurs at a lower temperature in the 3,3 '-DDS system. Molecular-level study reveals how the structural features of each curing agent appear in thermal and mechanical properties, offering important insights for epoxy system development. | Jeong, Hei Je; Kwon, Sung Hyun; Lim, Jihoon; Kwon, Woong; Park, Gun Hwan; Lee, Eunhye; Won, Jong Sung; Lee, Man Young; Jeong, Euigyung; Lee, Seung Geol | Ulsan Natl Inst Sci & Technol UNIST, Dept Mat Sci & Engn, Ulsan 44919, South Korea; Pusan Natl Univ, Sch Chem Engn, Busan 46241, South Korea; Pusan Natl Univ, Dept Organ Mat Sci & Engn, Busan 46241, South Korea; Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea; Agcy Def Dev, Def Mat & Energy Dev Ctr, POB 35, Daejeon 34060, South Korea | 59342082300; 57188644749; 58410415900; 57208867074; 59961178700; 57222626287; 55644371900; 56413127000; 35885596300; 35215858300 | sunghyun.kwon@pusan.ac.kr; wolfpack@knu.ac.kr; seunggeol.lee@unist.ac.kr; | POLYMERS | POLYMERS-BASEL | 2073-4360 | 17 | 12 | SCIE | POLYMER SCIENCE | 2024 | 4.9 | 19.7 | 0 | 0 | epoxy resin; molecular dynamics (MD); diglycidyl ether of bisphenol F (DGEBF); diaminodiphenyle sulfone (DDS); thermomechanical properties | CROSS-LINKED EPOXY; VISCOELASTIC PROPERTIES; MECHANICAL-PROPERTIES; FRACTURE-TOUGHNESS; FLUID INGRESS; CURING AGENTS; COMPOUND; NETWORKS; POLYMERS; STRENGTH | diaminodiphenyle sulfone (DDS); diglycidyl ether of bisphenol F (DGEBF); epoxy resin; molecular dynamics (MD); thermomechanical properties | Adhesives; Biomedical engineering; Curing; Density (specific gravity); Bisphenol F; Curing agents; Diaminodiphenyl sulfones; Diaminodiphenyle sulphone; Diglycidyl ether of bisphenol; Diglycidyl ether of bisphenol F; Epoxy; Molecular dynamic; Molecular levels; Thermomechanical properties; Glass transition; Molecular dynamics | English | 2025 | 2025-06-18 | 10.3390/polym17121694 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Nanoarchitectonics of porous carbon derived from urea-impregnated microporous triazine polymer in KOH activator for adsorptive removal of sulfonamides from water | A microporous covalent-organic polymer (triazine polymer, referred to as MCTP), was synthesized and subsequently carbonized, after loading urea and KOH (serving as an additional nitrogen source and activator, respectively), through high-temperature pyrolysis. This process resulted in materials named KUCDCs, which exhibited high porosity and a broader range of pore sizes compared to carbon materials produced without the addition of urea and KOH, referred to as CDC. KUCDCs, CDC, and commercially available activated carbon (AC) were evaluated for their ability to remove sulfonamide drugs, sulfamethoxazole (SMX) and sulfachlorpyridazine (SCP), from aqueous solution. Among these materials, KUCDC-800, which was carbonized at a temperature of 800 degrees C, demonstrated superior adsorption performances for sulfonamides, attributed to its high porosity, nitrogen content, and presence of surface oxygen groups. The adsorption capacities for SMX and SCP on KUCDC were notably higher than those on AC and MDC, with maximum capacities (Q0) of 619 and 554 mg/g for SMX and SCP, respectively. Notably, KUCDC-800 stands out as a recyclable adsorbent with the highest reported Q0 for SMX to date under near-neutral conditions. The exceptional performance of KUCDC in adsorbing SMX could be explained by its high porosity and surface functionalities for hydrogen bonding interactions with the adsorbate. | Ahmed, Imteaz; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Jhung, Sung/AAO-6683-2021 | 55377179600; 6701659467 | sung@knu.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 143 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2024 | 6 | 19.7 | 0 | 2025-05-07 | 0 | 0 | Adsorption; Covalent-organic polymer; porous carbon with N doping; Pyrolysis; Sulfonamide antibiotics | METAL-ORGANIC FRAMEWORKS; SULFAMETHOXAZOLE; DENITROGENATION; PERFORMANCE; MOFS | Adsorption; Covalent-organic polymer; porous carbon with N doping; Pyrolysis; Sulfonamide antibiotics | Carbonization; Catalytic cracking; Drug interactions; Gas adsorption; Hydrogen bonds; Hydrogen sulfide removal (water treatment); Ionomers; Micropores; Microporosity; Microporous materials; Semiconductor doping; Covalent-organic polymer; High porosity; Microporous; N-Doping; Organics; Porous carbon with N doping; Porous carbons; Sulfamethoxazole; Sulfonamide antibiotics; Sulphonamides; Potassium hydroxide | English | 2025 | 2025-03-25 | 10.1016/j.jiec.2024.08.041 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Self-Toughened Epoxy Resin via Hybridization of Structural Isomeric Curing Agents | Fracture toughness is a key property of epoxy resins with a high glass transition temperature (Tg), used in carbon fiber/epoxy composites for aerospace applications. Conventional toughening methods rely on adding toughening agents, often compromising the processibility and thermal stability. This study introduces a simple self-toughening approach that enhances the fracture toughness without sacrificing other properties by controlling the cured epoxy network structure. Tetraglycidyl 4,4 '-diaminodiphenylmethane (TGDDM) epoxy resin was cured using mixtures of structural isomeric curing agents, 3,3 '- and 4,4 '-diaminodiphenyl sulfone (3,3 '- and 4,4 '-DDS), at ratios of 7:3, 5:5, and 3:7. The optimal 7:3 ratio produced a resin with 30% higher fracture toughness compared to TGDDM/3,3 '-DDS and 100% higher than the TGDDM/4,4 '-DDS system. The Tg of the self-toughened resin ranged from 241 to 266 degrees C, which was intermediate between the Tg values of the TGDDM/3,3 '-DDS and TGDDM/4,4 '-DDS systems. This improvement is attributed to the higher crosslink density and reduced free volume of the epoxy network. These findings demonstrate that simply mixing isomeric curing agents enables self-toughening, providing a practical and efficient strategy to enhance the performance of high-Tg epoxy resins in advanced composite applications. | Kwon, Woong; Cheon, Jiyeon; Jeong, Hei Je; Won, Jong Sung; Kim, Byeong-Joo; Lee, Man Young; Lee, Seung Geol; Jeong, Euigyung | Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea; Ulsan Natl Inst Sci & Technol, Dept Mat Sci & Engn, Ulsan 44919, South Korea; Agcy Def Dev, Def Mat & Energy Technol Ctr, Yuseong POB 35, Daejeon 34060, South Korea | Lee, Seung Geol/B-3461-2015 | 57208867074; 59679253700; 59342082300; 55644371900; 56303380600; 56413127000; 35215858300; 35885596300 | kwoong7242@knu.ac.kr; ziyun32@naver.com; vkdnjchl@gmail.com; jswon@add.re.kr; dhfldhs727@naver.com; manyounglee@add.re.kr; seunggeol.lee@unist.ac.kr; wolfpack@knu.ac.kr; | POLYMERS | POLYMERS-BASEL | 2073-4360 | 17 | 5 | SCIE | POLYMER SCIENCE | 2024 | 4.9 | 19.7 | 0 | 2025-05-07 | 0 | 0 | epoxy resin; fracture toughness; diaminodiphenyl sulfone; curing agent; structural isomers | FRACTURE-TOUGHNESS; THERMAL-PROPERTIES; BEHAVIOR; KINETICS; MICROSTRUCTURE; PERFORMANCE; COMPOSITES; MORPHOLOGY; MECHANISM; PROPERTY | curing agent; diaminodiphenyl sulfone; epoxy resin; fracture toughness; structural isomers | Carbon carbon composites; Crosslinking; Curing; Elastomers; Fracture toughness; Isomerization; Isomers; Curing agents; Diaminodiphenyl sulfones; Diaminodiphenylmethane; Epoxy; Epoxy network; Glass transition temperature Tg; High-glass transition temperatures; Self toughening; Structural isomers; Toughened epoxies; Epoxy resins | English | 2025 | 2025-03 | 10.3390/polym17050695 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Use of biochar as a catalyst for biodiesel production | The economic viability of biodiesel (BD) production is highly dependent on conversion techniques using inexpensive oil feedstocks. In this study, BD was synthesised by the thermally induced (non-catalytic) transesterification of oil extracted from camellia seed (42.23 wt% lipid content). The BD yield from the non-catalytic transesterification of camellia oil was higher than that from the alkali-catalysed process. The BD yield from the alkali-catalysed transesterification of camellia oil for 60 min was 84.1 wt%, whereas that from the non-catalytic process for = 240 & ring;C). Thus, the reaction kinetics for the transesterification of camellia oil over camellia biochar was catalytically accelerated. Such efforts provide opportunities to enhance economic viability and realise the concept of a sustainable cycle in BD production. | Park, Gyeongnam; Lee, Dong-Jun; Kwon, Dohee; Kim, Jee Young; Jung, Sungyup; Tsang, Yiu Fai; Kwon, Eilhann E. | Hanyang Univ, Dept Earth Resources & Environm Engn, Seoul 04763, South Korea; Natl Inst Anim Sci NIAS, Dept Anim Environm, Wanju 55365, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Educ Univ Hong Kong, Dept Sci & Environm Studies, Hong Kong 999077, Peoples R China; Educ Univ Hong Kong, State Key Lab Marine Pollut, Hong Kong 999077, Peoples R China | Tsang, Yiu/AAJ-2524-2020; Kim, Jee Young/LKL-4818-2024; Kwon, Eilhann/A-1225-2012 | 59141730800; 57191538179; 57208275497; 59239932100; 55073290800; 22954605700; 9240622100 | ek2148@hanyang.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 142 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2024 | 6 | 19.7 | 2.56 | 2025-05-07 | 1 | 2 | Circular economy; Waste valorization; Thermo-chemical process; Biodiesel; Biochar | BIOFUEL PRODUCTION; OIL; TRANSESTERIFICATION; ENERGY; WASTE; CO2; BIOMASS; ESTERS; WATER | Biochar; Biodiesel; Circular economy; Thermo-chemical process; Waste valorization | Alkalinity; Catalysis; Catalysts; Reaction kinetics; Transesterification; Biochar; Biodiesel production; Circular economy; Economic viability; Non-catalytic transesterification; Oil feedstock; Thermo chemical process; Transesterifications; Waste valorizations; ]+ catalyst; Biodiesel | English | 2025 | 2025-02-25 | 10.1016/j.jiec.2024.07.046 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Acinetobacter baumannii OmpA hinders host autophagy via the CaMKK2-reliant AMPK-pathway | Outer membrane protein A (OmpA) plays a vital role in the interactions between Acinetobacter baumannii and host cells. Autophagy is a defense mechanism that hinders the intracellular replication of bacteria, thereby safeguarding cells against microbial infections. While it has been observed that A. baumannii triggers cellular autophagy, the precise role of its virulence protein OmpA in this process remains uncertain. In this study, we investigated the effects of A. baumannii OmpA (AbOmpA) on autophagy and explored the underlying molecular mechanisms. We found that AbOmpA exerted its autophagy-suppressive effect through inhibition of CaMKK2 phosphorylation. Compared to the wild-type strain, the ompA-deletion mutant strain displayed considerably enhanced autophagy induction, via the AMPK-ULK1 pathway. AbOmpA hindered starvation-induced autophagy, while A. baumannii-Omp33 (AbOmp33) and Escherichia coli-OmpA (EcOmpA) did not. Importantly, we confirmed that exogenous AbOmpA suppressed autophagy through the CaMKK2-AMPK-ULK1 pathway during A. baumannii infection. These findings reveal a novel mechanism for AbOmpA-mediated autophagy evasion, providing new insights into the pathogenesis of A. baumannii infection. | Woo, Kyungho; Kim, Dong Ho; Park, Ho-Sung; Oh, Man Hwan; Lee, Je Chul; Choi, Chul Hee | Chungnam Natl Univ, Sch Med, Dept Microbiol, Daejeon, South Korea; Chungnam Natl Univ, Translat Immunol Inst, Daejeon, South Korea; Chungnam Natl Univ, Sch Med, Dept Med Sci, Daejeon, South Korea; Chungnam Natl Univ, Syst Network Inflammat Control Res Ctr, Sch Med, Daejeon, South Korea; Dankook Univ, Coll Sci & Technol, Dept Microbiol, Cheonan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea | 57200657669; 57022526400; 57205288245; 57113010400; 58950747200; 57226436610 | choich@cnu.ac.kr; | MBIO | MBIO | 2150-7511 | 16 | 4 | SCIE | MICROBIOLOGY | 2024 | 4.7 | 19.9 | 0 | 2025-05-07 | 0 | 0 | Acinetobacter baumannii; autophagy; CaMKK2; outer membrane protein A | APOPTOSIS | Acinetobacter baumannii; autophagy; CaMKK2; outer membrane protein A | Acinetobacter baumannii; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Bacterial Outer Membrane Proteins; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Host-Pathogen Interactions; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Signal Transduction; beta actin; calcium calmodulin dependent protein kinase kinase 2; carrier protein; FAK family kinase interacting protein of 200 kDa; hydroxymethylglutaryl coenzyme A reductase kinase; lysosome associated membrane protein 2; mammalian target of rapamycin; outer membrane protein 33; outer membrane protein A; peptides and proteins; rapamycin derivative; sequestosome 1; serine threonine protein kinase ULK1; unclassified drug; calcium calmodulin dependent protein kinase kinase; CAMKK2 protein, human; hydroxymethylglutaryl coenzyme A reductase kinase; OMPA outer membrane proteins; outer membrane protein; serine threonine protein kinase ULK1; signal peptide; ULK1 protein, human; Acinetobacter baumannii; Acinetobacter baumannii infection; AMPK signaling; animal cell; animal experiment; animal model; animal tissue; Article; autophagosome; autophagy (cellular); Bagg albino mouse; cell viability; colony forming unit; confocal microscopy; controlled study; down regulation; Escherichia coli; female; flow cytometry; genetic transfection; human; human cell; immunoblotting; immunoprecipitation; lung parenchyma; mouse; nonhuman; protein expression; RAW 264.7 cell line; real time polymerase chain reaction; Western blotting; genetics; host pathogen interaction; metabolism; pathogenicity; phosphorylation; signal transduction | English | 2025 | 2025-04-09 | 10.1128/mbio.03369-24 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of Overweight and Obesity on the Response to Anti-TNF Therapy and Disease Course in Children With IBD | Background: This study aimed to evaluate the effect of overweight and obesity at the start of anti-TNF therapy on treatment response and relapse rate in children with inflammatory bowel disease (IBD). Methods: This multicenter, retrospective cohort study included 22 IBD centers in 14 countries. Children diagnosed with IBD in whom antitumor necrosis factor (anti-TNF) was introduced were included; those who were overweight/obese were compared with children who were well/undernourished. Results: Six hundred thirty-seven children (370 [58%] males; mean age 11.5 +/- 3.5 years) were included; 140 (22%) were in the overweight/obese group (OG) and 497 (78%) had BMI <= 1 SD (CG). The mean follow-up time was 141 +/- 78 weeks (median 117 weeks). There was no difference in the loss of response (LOR) to anti-TNF between groups throughout the follow-up. However, children in OG had more dose escalations than controls. Male sex and lack of concomitant immunomodulators at the start of anti-TNF were risk factors associated with the LOR. There was no difference in the relapse rate in the first year after anti-TNF introduction; however, at the end of the follow-up, the relapse rate was significantly higher in the OG compared with CG (89 [64%] vs 218 [44%], respectively, P < .001). Univariate and multivariate analysis revealed that being overweight/obese, having UC, or being of male sex were factors associated with a higher risk for relapse. Conclusions: Overweight/obese children with IBD were not at a higher risk of LOR to anti-TNF. Relapse in the first year after anti-TNF was introduced, but risk for relapse was increased at the end of follow-up. | Sila, Sara; Aloi, Marina; Cucinotta, Ugo; Gianolio, Laura; Granot, Maya; Hradsky, Ondrej; Hussey, Seamus; Kang, Ben; Karoliny, Anna; Kolho, Kaija-Leena; de Laffolie, Jan; Lega, Sara; Matar, Manar; Norsa, Lorenzo; Omiwole, Sharon; Orlanski-Meyer, Esther; Palomino, Laura; Rohani, Pejman; Scarallo, Luca; Sladek, Margaret; Sohouli, Mohammad Hassan; Urlep, Darja; Yerushalmy-Feler, Anat; Zifman, Eyal; Hojsak, Iva | Univ Zagreb, Med Sch, Childrens Hosp Zagreb, Zagreb 41001, Croatia; Sapienza Univ, Umberto I Hosp, Pediat Gastroenterol Unit, Rome, Italy; Univ Messina, Pediat Gastroenterol & Cyst Fibrosis Unit, Dept Human Pathol Adulthood & Childhood, Messina, Italy; Royal Hosp Children & Young People, Dept Gastroenterol Hepatol & Nutr, Edinburgh, Scotland; Tel Aviv Univ, Fac Med, Sheba Med Ctr, Pediat Gastroenterol & Nutr Unit, Tel Aviv, Israel; Charles Univ Prague, Fac Med 2, Dept Paediat, Prague, Czech Republic; Univ Hosp Motol, Prague, Czech Republic; Univ Coll Dublin, DOCHAS Grp, Childrens Hlth Ireland, Dublin, Ireland; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Heim Pal Natl Pediat Inst, Budapest, Hungary; Univ Helsinki, Helsinki, Finland; HUS, Childrens Hosp, Helsinki, Finland; Justus Liebig Univ Giessen, Childrens Hosp, Giessen, Germany; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy; Tel Aviv Univ, Inst Gastroenterol Nutr & Liver Dis, Sackler Fac Med, Schneider Childrens Med Ctr, Tel Aviv, Israel; ASST Papa Giovanni XXIII, Pediat Hepatol Gastroenterol & Transplantat Dept, Bergamo, Italy; Univ Milan, Childrens Hosp Vittore Buzzi, Pediat Dept, Milan, Italy; Hebrew Univ Jerusalem, Juliet Keidan Inst Pediat Gastroenterol Hepatol &, Shaare Zedek Med Ctr, Jerusalem, Israel; Hosp Infantil Univ Nino Jesus, Gastroenterol & Nutr Unit, Madrid, Spain; Univ Tehran Med Sci, Pediat Gastroenterol & Hepatol Res Ctr, Childrens Med Ctr, Tehran, Iran; Meyer Children Hosp IRCCS, Gastroenterol & Nutr Unit, Florence, Italy; Jagiellonian Univ, Med Coll, Dept Pediat Gastroenterol & Nutr, Krakow, Poland; Univ Med Ctr Ljubljana, Pediat Gastroenterol & Liver Unit, Univ Childrens Hosp, Ljubljana, Slovenia; Tel Aviv Univ, Pediat Gastroenterol Inst, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel; Tel Aviv Univ, Fac Med, Tel Aviv, Israel; Meir Med Ctr, Pediat gastroenterol Clin, Kefar Sava, Israel; Tel Aviv Univ, Sch Med, Tel Aviv, Israel | ; LEGA, SARA/AAB-8758-2019; 康, 奔/JMQ-0812-2023; SCARALLO, LUCA/GRF-4722-2022; Hojsak, Iva/AAI-8937-2020; Cucinotta, Ugo/IRZ-3474-2023; de Laffolie, Jan/K-2215-2019; Hussey, Séamus/F-8810-2015; Aloi, Marina/K-2496-2016; Hradsky, Ondrej/L-5899-2019; Hussey, Seamus/F-8810-2015; Norsa, Lorenzo/I-1462-2018 | 57204714392; 22950164000; 57211347124; 57204451821; 57204356090; 24280716400; 25636843300; 57194823199; 57191440581; 6701638121; 54941228500; 37665333900; 57193614026; 55207312500; 59897716400; 57204636804; 58060885200; 57193691921; 57204424323; 57225330898; 57218370761; 8964706700; 56016081800; 23989876100; 7801459343 | ivahojsak@gmail.com; | INFLAMMATORY BOWEL DISEASES | INFLAMM BOWEL DIS | 1078-0998 | 1536-4844 | 31 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 4.3 | 20.1 | 0 | 2025-06-11 | 1 | 1 | Crohn's disease; ulcerative colitis; adalimumab; infliximab | INFLAMMATORY-BOWEL-DISEASE; PEDIATRIC CROHNS-DISEASE; MANAGEMENT; OUTCOMES; IMPACT | adalimumab; Crohn’s disease; infliximab; ulcerative colitis | Adolescent; Child; Female; Follow-Up Studies; Humans; Inflammatory Bowel Diseases; Infliximab; Male; Obesity; Overweight; Recurrence; Retrospective Studies; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; adalimumab; albumin; C reactive protein; calgranulin; hemoglobin; infliximab; tumor necrosis factor; tumor necrosis factor inhibitor; infliximab; tumor necrosis factor; Article; body mass; body weight; body weight loss; child; clinical outcome; cohort analysis; controlled study; Crohn disease; disease activity; disease course; disease duration; drug dose escalation; drug therapy; female; follow up; human; inflammatory bowel disease; major clinical study; male; obesity; outcome assessment; recurrence risk; retrospective study; risk factor; school child; treatment response; ulcerative colitis; adolescent; clinical trial; complication; drug therapy; inflammatory bowel disease; multicenter study; recurrent disease; treatment outcome | English | 2025 | 2025-05 | 10.1093/ibd/izae165 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Energizing the fog: a systematic survey on task scheduling strategies for energy optimization | Fog computing is an emerging paradigm that brings computation closer to data sources, reducing latency, enhancing data privacy, and conserving network bandwidth. However, it also introduces challenges related to energy efficiency due to the increased frequency of local processing. This study conducts a comprehensive survey of task-scheduling algorithms focused on optimizing energy usage within this paradigm. We review 51 research articles published over the past six years, categorizing the algorithms into heuristic, meta-heuristic, AI-driven, and hybrid approaches. Each algorithm is critically evaluated based on its objectives, strategies, and energy management capabilities, with a focus on key performance metrics such as energy consumption, computational latency, task completion time, and quality of service. Furthermore, this study highlights potential research gaps and suggests future directions for improving energy efficiency in fog computing. This survey offers valuable guidance to researchers designing and implementing energy-efficient task scheduling algorithms within fog computing environments by synthesizing these insights and presenting practical recommendations. | Nagabushnam, Ganesan; Choi, Yundo; Kim, Kyong Hoon | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | Nagabushnam, Ganesan/ABA-2780-2021 | 57226713013; 59394897700; 15065463500 | ndganesan@gmail.com; ydchoi97@knu.ac.kr; kyong.kim@knu.ac.kr; | CLUSTER COMPUTING-THE JOURNAL OF NETWORKS SOFTWARE TOOLS AND APPLICATIONS | CLUSTER COMPUT | 1386-7857 | 1573-7543 | 28 | 6 | SCIE | COMPUTER SCIENCE, THEORY & METHODS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.1 | 20.1 | 0 | 0 | Fog computing; Energy-efficient task scheduling; Heuristic algorithms; Metaheuristic techniques; AI-driven scheduling; Hybrid scheduling approaches; Quality of service (QoS); Green computing; Future trends in fog computing | RESOURCE-ALLOCATION; IOT; SIMULATION; EDGE; ARCHITECTURE; MANAGEMENT; INTERNET; CENTERS; TOOLKIT | AI-driven scheduling; Energy-efficient task scheduling; Fog computing; Future trends in fog computing; Green computing; Heuristic algorithms; Hybrid scheduling approaches; Metaheuristic techniques; Quality of service (QoS) | Data privacy; Energy efficiency; Energy management; Energy utilization; Fog; Green computing; Heuristic algorithms; Heuristic methods; Multitasking; Optimization; Scheduling algorithms; AI-driven scheduling; Driven scheduling; Energy efficient; Energy-efficient task scheduling; Future trend in fog computing; Future trends; Heuristics algorithm; Hybrid scheduling; Hybrid scheduling approach; Meta-heuristic techniques; Quality of service; Quality-of-service; Tasks scheduling; Fog computing | English | 2025 | 2025-10 | 10.1007/s10586-025-05200-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Faddeer: a deep multi-agent reinforcement learning-based scheduling algorithm for aperiodic tasks in heterogeneous fog computing networks | Fog computing has become essential for real-time applications in domains such as autonomous driving, smart cities, Industry 4.0, and large-scale IoT ecosystems, where low latency and efficient resource utilization are critical. However, scheduling aperiodic tasks in fog environments remains a significant challenge, particularly when ensuring strict deadline adherence, energy efficiency, and optimized use of heterogeneous low-power devices. This challenge is further intensified by the dynamic and unpredictable nature of fog networks, making the problem NP-hard. To address these issues, we propose FADDEER (fog adaptive deadline-driven energy efficient reinforcement), a novel deep multi-agent reinforcement learning (Deep MARL)-based scheduling algorithm that integrates earliest deadline first (EDF) and asynchronous advantage actor-critic (A3C) to enable adaptive, scalable, and deadline-aware task scheduling. FADDEER intelligently allocates aperiodic tasks to distributed fog nodes, dynamically balancing task makespan, energy consumption, and resource utilization. Experiments were conducted using the COSCO simulation framework with workloads ranging from 100 to 1,000 aperiodic tasks distributed across fog networks of 10 to 100 nodes, respectively. The results demonstrate that FADDEER consistently outperforms state-of-the-art algorithms, including A3C, multi-agent deep deterministic policy gradient (MADDPG), genetic algorithm, particle swarm optimization (PSO), EDF achieving up to 4% higher deadline adherence and up to 55% lower energy consumption compared to the next best alternatives. Moreover, FADDEER achieved up to 19.4% lower makespan under high task loads and significantly reduced scheduling time, validating its efficiency and responsiveness in dynamic fog environments. These outcomes highlight FADDEER's robustness, scalability, and effectiveness for real-time IoT task scheduling in fog computing frameworks. | Nagabushnam, Ganesan; Kim, Kyong Hoon | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | Nagabushnam, Ganesan/ABA-2780-2021 | 57226713013; 15065463500 | ndganesan@gmail.com; kyong.kim@knu.ac.kr; | CLUSTER COMPUTING-THE JOURNAL OF NETWORKS SOFTWARE TOOLS AND APPLICATIONS | CLUSTER COMPUT | 1386-7857 | 1573-7543 | 28 | 6 | SCIE | COMPUTER SCIENCE, THEORY & METHODS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.1 | 20.1 | N/A | 0 | 0 | Aperiodic; Asynchronous advantage actor-critic; Deadline task; Deep multi-agent reinforcement learning; IoT; Heterogeneous fog; Cloud; Task scheduling | Aperiodic; Asynchronous advantage actor-critic; Cloud; Deadline task; Deep multi-agent reinforcement learning; Heterogeneous fog; IoT; Task scheduling | Autonomous agents; Computational complexity; Deep learning; Deep reinforcement learning; Energy utilization; Fog; Fog computing; Green computing; Intelligent agents; Learning algorithms; Multi agent systems; Multitasking; Response time (computer systems); Scheduling algorithms; Actor critic; Aperiodic; Asynchronous advantage actor-critic; Deadline task; Deep multi-agent reinforcement learning; Energy efficient; Heterogeneous fog; IoT; Multi-agent reinforcement learning; Tasks scheduling; Particle swarm optimization (PSO) | English | 2025 | 2025-10 | 10.1007/s10586-025-05435-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Impact of the morphology of logged areas on medium and large mammal communities in forests | ContextThe morphology of logged areas (MLA) can impact medium and large mammal habitat. Assessing MLAs with landscape metrics facilitates sustainable forest management and biodiversity conservation.ObjectivesWe quantified MLAs and assessed their impacts on medium and large mammals.MethodsWe assessed mammal occurrence using camera traps in 24 logged and 26 unlogged sites in South Korea and collected environmental variables, including nine MLA indices, at the microscale (50 m), mesoscale (500 m), and macroscale (1 km). After performing a principal component analysis (PCA), linear mixed and single-species occupancy models were used to assess the effects of principal components on mammal diversity and species-specific responses.ResultsIn the PCA results, MLA components were notably associated with spatial scales, with 50-m-scale indices separated from larger-scale indices. Several MLA components showed strong associations. Microscale MLA traits, particularly edge complexity and reduced unlogged patch connectivity, negatively affected diversity. At the species level, omnivores-specifically, wild boar (Sus scrofa) and Asian badger (Meles leucurus)-were negatively influenced by the same MLA component influencing diversity. In contrast, leopard cats (Prionailurus bengalensis) showed a preference for simplified spatial arrangements-characterized by fewer logged areas and short edges-at the 500 m and 1 km scales.ConclusionsOur findings highlight the importance of MLAs in mitigating logging impacts on mammals, as some morphologies can reduce exposure and provide more favorable habitat. Designing logged areas based on MLA indices can help balance conservation and resource use. | Kim, Mihyeon; Kim, Hyo Gyeom; Fath, Brian D.; Park, Hee-Bok; Hong, Sungwon | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Korea Environm Inst, Environm Assessment Grp, Sejong 30147, South Korea; Towson Univ, Dept Biol Sci, Towson, MD USA; Int Inst Appl Syst Anal, Adv Syst Anal, Laxenburg, Austria; Masaryk Univ, Dept Environm Studies, Brno, Czech Republic; Natl Inst Ecol, Res Ctr Endangered Species, Yeongyang 36531, Gyeongbuk, South Korea | shong@knu.ac.kr; | LANDSCAPE ECOLOGY | LANDSCAPE ECOL | 0921-2973 | 1572-9761 | 40 | 7 | SCIE | ECOLOGY;GEOGRAPHY, PHYSICAL;GEOSCIENCES, MULTIDISCIPLINARY | 2024 | 3.7 | 20.1 | 0 | Biodiversity; Conservation; Logging; Forestry; Landscape morphology; Mammals | LANDSCAPE HETEROGENEITY; SPATIAL-DISTRIBUTION; FRAGMENTATION; PREY; RESPONSES; CARNIVORE; DEER; SIZE; CONFIGURATION; CONSERVATION | English | 2025 | 2025-07-01 | 10.1007/s10980-025-02140-x | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | One-year Safety and Effectiveness of Ustekinumab in Patients With Crohn's Disease: The K-STAR Study | Background This study investigated the safety and effectiveness of ustekinumab (UST) in Korean patients with Crohn's disease (CD). Methods Adult patients with CD treated with UST were prospectively enrolled in the K-STAR (Post-MarKeting Surveillance for Crohn's Disease patients treated with STelARa) study between April 2018 and April 2022. Both the clinical effectiveness and adverse effects of UST therapy were analyzed. Missing data were handled using nonresponder imputation (ClinicalTrials.gov Identifier: NCT03942120). Results Of the 464 patients enrolled from 44 hospitals across Korea, 457 and 428 patients (Crohn's disease activity index >= 150) were included in the safety analysis and effectiveness analysis sets, respectively. At weeks 16 to 20 after initiating UST, clinical response, clinical remission, and corticosteroid-free remission rates were 75.0% (321 of 428), 64.0% (274 of 428), and 61.9% (265 of 428), respectively. At week 52 to 66, clinical response, clinical remission, and corticosteroid-free remission rates were 62.4% (267 of 428), 52.6% (225 of 428), and 50.0% (214 of 428), respectively. Combined effectiveness (clinical response + biochemical response) was achieved in 40.0% (171 of 428) and 41.6% (178 of 428) at week 16 to 20 and week 52 to 66, respectively. Biologic-na & iuml;ve patients exhibited significantly higher rates of combined effectiveness than biologic-experienced patients (50.3% vs 30.7% at week 16-20, P < .001; 47.7% vs 36.0% at week 52-66, P = .014). No additional benefits were observed with the concomitant use of immunomodulators. Ileal location was independently associated with a higher probability of clinical remission compared with colonic or ileocolonic location at week 52 to 66. Adverse and serious adverse events were observed in 28.2% (129 of 457) and 12.7% (58 of 457), respectively, with no new safety signal associated with UST treatment. Conclusions Ustekinumab was well-tolerated, effective, and safe as induction and maintenance therapy for CD in Korea. | Lee, Chang Kyun; Moon, Won; Chun, Jaeyoung; Kim, Eun Soo; Kim, Hyung Wook; Yoon, Hyuk; Kim, Hyun Soo; Lee, Yoo Jin; Choi, Chang Hwan; Jung, Yunho; Park, Sung Chul; Song, Geun Am; Lee, Jong Hun; Jung, Eun Suk; Kim, Youngdoe; Jung, Su Young; Choi, Jong Min; Ye, Byong Duk | Kyung Hee Univ, Kyung Hee Univ Hosp, Ctr Crohns & Colitis, Coll Med,Dept Gastroenterol, Seoul, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Cheonan, South Korea; Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Dong A Univ, Med Ctr, Dept Internal Med, Busan, South Korea; Janssen Korea Ltd, Med Affairs, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea; Univ Ulsan, Inflammatory Bowel Dis Ctr, Asan Med Ctr, Coll Med, Seoul, South Korea; Univ Ulsan, Digest Dis Res Ctr, Coll Med, Seoul, South Korea | Kim, Yong-Sik/J-5418-2012; Yoon, Hyuk/AAT-4978-2020; Kim, Seong Cheol/ABD-1493-2022; Chun, Jaeyoung/G-2921-2015; Moon, Won/GLR-9368-2022; Ye, Byong/AAF-4955-2020; Lee, Jong-Seok/J-5603-2012; Park, Sung Chul/AGO-1773-2022; Lee, Chang/AAI-1012-2020 | 26434331200; 55784250800; 55936772800; 59326995400; 59896422300; 34881293100; 59776957500; 59656867900; 55741566200; 54789008200; 59730906100; 59693739300; 55371551100; 57206503661; 57192809503; 57898510700; 59900318900; 59445321600 | bdye@amc.seoul.kr; | INFLAMMATORY BOWEL DISEASES | INFLAMM BOWEL DIS | 1078-0998 | 1536-4844 | 31 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 4.3 | 20.1 | 3.31 | 2025-06-11 | 1 | 1 | ustekinumab; Crohn's disease; safety; effectiveness; Korea | MAINTENANCE THERAPY; DOUBLE-BLIND; EFFICACY; INDUCTION | Crohn’s disease; effectiveness; Korea; safety; ustekinumab | Adult; Crohn Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Product Surveillance, Postmarketing; Prospective Studies; Remission Induction; Republic of Korea; Treatment Outcome; Ustekinumab; Young Adult; adalimumab; C reactive protein; calgranulin; corticosteroid; infliximab; tumor necrosis factor antibody; ustekinumab; vedolizumab; abdominal discomfort; abdominal pain; adult; adverse event; anemia; Article; Crohn disease; Crohn Disease Activity Index; disease duration; disease severity; dizziness; drug efficacy; drug safety; endoscopy; female; fever; folliculitis; hematochezia; hospitalization; human; hypertransaminasemia; incidence; intestine obstruction; major clinical study; male; monotherapy; multicenter study; observational study; remission; sepsis; Short Inflammatory Bowel Disease Questionnaire; treatment response; upper respiratory tract infection; vagina infection; clinical trial; Crohn disease; drug therapy; follow up; middle aged; postmarketing surveillance; prospective study; South Korea; treatment outcome; young adult | English | 2025 | 2025-05 | 10.1093/ibd/izae171 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Public key-based search on encrypted data using blockchain and non-blockchain enabled cloud storage: a comprehensive survey, analysis and future research scopes | Cloud-based storage service has emerged as a promising alternative to managing local storage, offering users additional features, such as storage, backup, and restoration of various resources, including software, applications, and sensitive private information, within a virtual database, while ensuring data confidentiality and security. However, the widespread use of cloud services by individuals and organisations raises concerns regarding user accessibility and data security due to increasing social threats and adversarial attacks. Searchable encryption (SE) has been introduced to address these issues, providing a secure environment for a convenient and effective way of data searching and sharing. SE models have been advanced by integrating blockchain functionalities to tackle certain existing vulnerabilities and enhance user accessibility, data privacy, and integrity. This survey work explores various research works on SE techniques leveraging cloud and blockchain functionalities, discussing and categorizing the diverse approaches based on different criteria. This study also discusses the different enhancements made to SE techniques over the years, including the underlying requirements that led to the inclusion of blockchain functionalities. Moreover, this study provides a comparative analysis of existing survey works done in this area, which highlights a lack of recent literature surveys that thoroughly explore blockchain-based public key encryption with keyword search (PEKS) schemes. Particularly, we delve into the technical aspects of PEKS by classifying, analyzing and comparing different functionalities based on various aspects. The survey concludes with a comparative analysis of existing PEKS solutions and a discussion on identified research gaps, aiming to improve future research on PEKS approaches in this emerging field. | Mallick, Debjani; Das, Ashok Kumar; Varri, Uma Sankararao; Park, Youngho | Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Korea Univ, Coll Informat, Dept Comp Sci & Engn, Seoul 02841, South Korea; SRM Univ AP, Comp Sci & Engn, Amaravati 522240, Andhra Pradesh, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Das, Ashok Kumar/U-2790-2019 | 59322848700; 55450732800; 57211915720; 56962990300 | debjani.mallick@research.iiit.ac.in; iitkgp.akdas@gmail.com; umasankararao.v@srmap.edu.in; parkyh@knu.ac.kr; | CLUSTER COMPUTING-THE JOURNAL OF NETWORKS SOFTWARE TOOLS AND APPLICATIONS | CLUSTER COMPUT | 1386-7857 | 1573-7543 | 28 | 6 | SCIE | COMPUTER SCIENCE, THEORY & METHODS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 4.1 | 20.1 | 0 | 0 | Searchable encryption; Public key cryptosystem; Blockchain; Cloud storage; Security | PROXY RE-ENCRYPTION; ATTRIBUTE-BASED ENCRYPTION; IDENTITY-BASED ENCRYPTION; KEYWORD RANKED SEARCH; AUTHENTICATED ENCRYPTION; SYMMETRIC-ENCRYPTION; INDUSTRIAL INTERNET; GUESSING ATTACKS; SINGLE DATABASE; SEMANTIC SEARCH | Blockchain; Cloud storage; Public key cryptosystem; Searchable encryption; Security | Application programs; Cloud storage; Data privacy; Public key cryptography; Search engines; Block-chain; Cloud storages; Comparative analyzes; Encryption technique; Keyword search; Public key cryptosystems; Public-key encryption; Searchable encryptions; Security; Survey works; Blockchain | English | 2025 | 2025-10 | 10.1007/s10586-024-05066-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The transdiagnostic role of event-related rumination on internalizing and externalizing symptoms during the pandemic: a two-wave longitudinal study | Background Rumination is a well-established transdiagnostic vulnerability. However, few studies have explored the transdiagnostic role of event-related rumination. Moreover, there is a paucity of longitudinal studies clarifying the temporal precedence of event-related rumination. Therefore, this study aimed to longitudinally examine the mediating paths of event-related rumination between perceived stress and diverse symptomatic dimensions.Methods A representative sample of Korean adults (N = 316) was recruited online and they completed a package of self-reported measures twice over a one-year period. Using prospective two-wave data collected during the pandemic, longitudinal indirect effects were examined using the hypothesized path model.Results As expected, intrusive rumination acted as a transdiagnostic mediator in both internalizing and externalizing psychopathology and was positively associated with all subsequent symptom dimensions, except mania. Meanwhile, the beneficial role of deliberate rumination was less-transdiagnostic.Conclusion These initial findings suggest that event-related rumination could be considered a transdiagnostic mediator and a target for prevention and intervention to maintain mental health during and after the pandemic. | Kim, Bin-Na; Kang, Hyo Shin; Park, Jungkyu | Gachon Univ, Dept Psychol, Seongnam, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea | 56125185200; 57219595147; 56206565000 | hyoshin.kang@knu.ac.kr; jkp@knu.ac.kr; | FRONTIERS IN PSYCHOLOGY | FRONT PSYCHOL | 1664-1078 | 16 | SSCI | PSYCHOLOGY, MULTIDISCIPLINARY | 2024 | 2.9 | 20.1 | 0 | 2025-05-07 | 0 | 0 | rumination; transdiagnostic; internalizing; externalizing; psychopathology | DEPRESSION; ANXIETY; WORRY; PSYCHOPATHOLOGY; VALIDATION; HEALTH; ANGER | externalizing; internalizing; psychopathology; rumination; transdiagnostic | English | 2025 | 2025-03-18 | 10.3389/fpsyg.2025.1421958 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A Ge/GeO2/Titanate nanocomposite with high energy density and enhanced long-term stability for lithium-ion batteries | This study introduces a novel Ge/GeO2/Titanate composite to address the limitations of conventional Ge-based anode materials, including volume expansion, particle aggregation, and unstable SEI formation during repeated charge-discharge cycles. By combining two-dimensional (2D) layered titanate nanosheets with Ge/GeO2 nano- particles, the composite achieves enhanced structural stability and outstanding electrochemical performance. The 2D titanate nanosheets effectively mitigate the volume expansion of Ge/GeO2 nanoparticles, prevent particle aggregation, and maintain the long-term structural stability of the electrode while enhancing lithium-ion and electron transport pathways. Moreover, the thin amorphous GeO2 layer on the Ge/GeO2 nanoparticles suppresses excessive reactions with the electrolyte, promotes uniform and stable SEI formation, reduces irreversible capacity loss, and further contributes to the electrode's long-term stability. The Ge/GeO2/Titanate composite exhibits exceptional performance, retaining a high capacity of 925.8 mAh/g (similar to 94 % of the theoretical capacity) after 350 cycles at 0.1 A/g. It also achieves capacity retention rates of 88.3 % and 73.4 % after 1200 charge-discharge cycles at high current densities of 2.0 A/g and 5.0 A/g, respectively. | Lee, Minseop; Park, Ji-Ho; Park, Dong-Jun; Paek, Seung-Min | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | Lee, Minseop/JVZ-7552-2024; Paek, Seung-Min/E-4667-2011 | 57201550392; 58811989300; 59487092100; 7102686289 | smpaek@knu.ac.kr; | JOURNAL OF SOLID STATE CHEMISTRY | J SOLID STATE CHEM | 0022-4596 | 1095-726X | 346 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR;CHEMISTRY, PHYSICAL | 2024 | 3.5 | 20.2 | 0 | 2025-05-07 | 2 | 3 | Titanate; Germanium; Germanium oxide; Lithium-ion batteries; Anodes; Nanocomposites | REDUCED GRAPHENE OXIDE; HIGH-RATE ANODE; HIGH-CAPACITY; GERMANIUM; PERFORMANCE; NANOSHEETS; CARBON; GE; NANOPARTICLES | Anodes; Germanium; Germanium oxide; Lithium-ion batteries; Nanocomposites; Titanate | Electrolytes; Nanoclay; Nanocomposites; Nanoparticles; Nanosheets; Charge-discharge cycle; Germaniums (Ge); Ion batteries; Lithium ions; Long term stability; Particles aggregations; SEI formations; Titanate; Two-dimensional; Germanium oxides | English | 2025 | 2025-06 | 10.1016/j.jssc.2025.125256 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reassessing the Role of the Neurofilament Light Chain in Guillain-Barre Syndrome: Issues in Diagnosis and Subgroup Classification | Seok, Hung Youl; Eun, Mi-Yeon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea | Eun, Mi-Yeon/AAV-2877-2021; Seok, Hung Youl/HZI-4365-2023 | 24472118000; 36463396500 | eunmiyn@gmail.com; | EUROPEAN JOURNAL OF NEUROLOGY | EUR J NEUROL | 1351-5101 | 1468-1331 | 32 | 2 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 3.9 | 20.2 | 0 | 2025-05-07 | 0 | 0 | diagnosis; Guillain-Barre syndrome; Miller Fisher syndrome; neurofilament light chain | diagnosis; Guillain-Barre syndrome; Miller Fisher syndrome; neurofilament light chain | neurofilament protein; ataxia; chronic inflammatory demyelinating polyneuropathy; demyelinating neuropathy; disease classification; disease severity; Guillain Barre syndrome; human; Letter; light chain; limb weakness; ophthalmoplegia; protein function; reflex; classification; clinical article; diagnosis; female; Guillain Barre syndrome; letter; light chain; neurofilament | English | 2025 | 2025-02 | 10.1111/ene.70060 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis | Neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD), are marked by progressive neuronal loss. Regulated cell death programs (i.e., necroptosis) as well as homeostatic mechanisms (i.e., autophagy) can modulate disease pathogenesis. Low-dose carbon monoxide (CO) has been shown to activate cytoprotective responses in various models of tissue injury. Our study investigates the protective roles of CO in neurodegenerative disease through the modulation of necroptosis and autophagy programs. We found that CO activates the Protein kinase RNA (PKR)-like ER kinase (PERK) branch of the unfolded protein response (UPR) and the calcineurin pathway, leading to significant neuroprotective effects in cellular and mouse models of PD. CO-induced PERK activation promotes the nuclear translocation of transcription factor EB (TFEB). Subsequently, TFEB enhances autophagy through increased expression of autophagy-related genes and inhibits necroptosis by suppressing the phosphorylation and oligomerization of Mixed Lineage Kinase Domain-Like Pseudokinase (MLKL), a key necroptosis regulator. Furthermore, CO enhances the expression of Beclin 1, which inhibits necroptosis, independently of its autophagic function, by regulating MLKL oligomerization. Our findings suggest that modulation of the PERK-calcineurin pathway and downstream activation of cellular defense mechanisms by CO may serve as a promising therapeutic approach to mitigate neuronal loss in neurodegenerative diseases. | Park, Jeongmin; Jin, LiHua; Song, Hyun-Chul; Chen, Yingqing; Jang, Eun Young; Park, Gyu Hwan; Yang, Chae Ha; Ryter, Stefan W.; Park, Jeong Woo; Zheng, Min; Joe, Yeonsoo; Chung, Hun Taeg | Daegu Haany Univ, Coll Korean Med, Gyongsan, South Korea; YanBian Univ, Sch Nursing, Yanji, Peoples R China; Univ Ulsan, Sch Biol Sci, Ulsan, South Korea; Dalian Univ, Dept Pharmacol, Med Coll, Dalian, Peoples R China; Korea Inst Toxicol, Ctr Convergence Toxicol Res, Daejeon, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Daegu Haany Univ, Coll Korean Med, Daegu, South Korea; Proterris Inc, Boston, MA USA; YanBian Univ, Affiliated Hosp, Dept Neurol, Yanji, Peoples R China | 49763812900; 59351132300; 57208316428; 55961777500; 59919298500; 9939639300; 59919484500; 6602484026; 59920034500; 46961616900; 55114313900; 57211875879 | joeyeonsoo@dhu.ac.kr; chunght@dhu.ac.kr; | CELL DEATH DISCOVERY | CELL DEATH DISCOV | 2058-7716 | 11 | 1 | SCIE | CELL BIOLOGY | 2024 | 7 | 20.3 | 0 | 2025-06-11 | 0 | 0 | NEURONAL CELL-DEATH; PARKINSONS-DISEASE; CARBON-MONOXIDE; TFEB; AUTOPHAGY; INFLAMMATION; PROTECTS; MODEL | English | 2025 | 2025-05-27 | 10.1038/s41420-025-02530-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: