2025 연구성과 (69 / 151)

※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Apparent metabolizable energy concentration and ileal amino acid digestibility in cereal grains fed to broiler chickens ⓘ Objective: This study aimed to determine apparent metabolizable energy concentrations and ileal amino acid (AA) digestibility in cereal grains and to compare those metabolizable energy values between the total collection and index methods for 21day old broilers. Methods: On day 17 post hatch, a total of 336 Ross 308 male broilers were assigned to 6 dietary treatments with 8 replicate cages (7 birds/cage). Five experimental diets were formulated to incorporate non extruded corn, extruded corn, wheat, wheat flour, and barley as the sole source of AA and energy. Results: Retention of dry matter and nitrogen, and energy concentrations in cereal grains determined by the total collection method were greater (p<0.05) than those determined by the index method. Energy concentrations of non extruded and extruded corn were greater (p<0.05) than those of wheat, wheat flour, and barley. Wheat flour exhibited greater (p<0.05) ileal AA digestibility than non extruded and extruded corn. Extruded corn and wheat showed comparable ileal AA digestibility values, whereas barley had the lowest among cereal grains. Conclusion: Energy concentrations of cereal grains determined by the total collection method were greater than those determined by the index method. Energy concentrations of non extruded and extruded corn were greater compared to wheat, wheat flour, and barley, irrespective of the method used. The ileal AA digestibility in wheat flour was the greatest, followed by non extruded corn, extruded corn, wheat, and barley in broilers. ⓘ Yoon, June Hyeok; Kong, Changsu ⓘ Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea ⓘ ⓘ 57995779900; 36027521600 ⓘ changsukong@gmail.com; ⓘ ANIMAL BIOSCIENCE ⓘ ANIM BIOSCI ⓘ 2765-0189 2765-0235 38 3 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2024 2.5 19.2 0 2025-05-07 ⓘ 0 0 Amino Acid; Broiler; Cereal Grain; Digestibility; Metabolizable Energy ⓘ DRIED DISTILLERS GRAINS; WHEAT BY-PRODUCTS; NUTRIENT DIGESTIBILITY; FEED INGREDIENTS; CHROMIC OXIDE; PARTICLE-SIZE; CORN; SOLUBLES; BARLEY; PERFORMANCE ⓘ Amino Acid; Broiler; Cereal Grain; Digestibility; Metabolizable Energy ⓘ ⓘ English 2025 2025-03 10.5713/ab.24.0398 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Effects of individual and combined doses of added nitrite and nitrate on the quality of dry-fermented sausage ⓘ Objective: We aimed to investigate the impacts of nitrate and nitrite on the salami fermentation process. Methods: Experimental groups of dry-fermented sausage were prepared with 100 ppm nitrite (T1), 150 ppm nitrite (T2), and 100 ppm nitrite+50 ppm nitrate (T3). Salami quality was evaluated after a 30-day fermentation-drying process. Results: There were no significant differences in residual nitrite levels between T1 and T2, while the T3 samples exhibited the highest residual nitrite. T2 (150 ppm nitrite) showed a significantly higher pH value compared to T1 (100 ppm nitrite). Water activity was lowest in the T2 sample. T1 had a higher thiobarbituric acid reactive substances value than other treatments. In the color analysis, the L* values of T1 and T2 were significantly higher than those of T3, whereas the a* values were significantly higher in T3. In the texture analysis, T3 exhibited a higher shear force than T1 and T2. In the microbial analysis, adding 50 and 100 ppm of nitrite did not reduce the total plate count (TPC) and lactic acid bacteria count. However, T3 had a lower TPC than T1 and T2. Conclusion: The results suggest that different levels of nitrite/nitrate affect salami quality. This study is a valuable resource for understanding how using nitrite and nitrate alone or in combination affects quality in salami production. ⓘ Kang, Suk Nam; Yim, Donggyun ⓘ Daegu Univ, Dept Biotechnol, Gyongsan, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju, South Korea ⓘ ⓘ 59835401100; 56727813800 ⓘ dgyim@knu.ac.kr; ⓘ ANIMAL BIOSCIENCE ⓘ ANIM BIOSCI ⓘ 2765-0189 2765-0235 38 6 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2024 2.5 19.2 N/A ⓘ 0 0 Color Analysis; Microbial Analysis; Residual Nitrite; Texture Analysis; Water Activity ⓘ CURED MEAT-PRODUCTS; PARAMETERS ⓘ Color Analysis; Microbial Analysis; Residual Nitrite; Texture Analysis; Water Activity ⓘ ⓘ English 2025 2025-06 10.5713/ab.24.0561 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Growth performance of pigs fed low-protein diets supplemented with crystalline amino acids at different growth stages ⓘ Objective: This study aimed to investigate the impact of reducing dietary crude protein (CP) coupled with supplementation of indispensable amino acids (AA) on growth performance of pigs at different growth stages. Methods: A total of 126 (63 barrows and 63 gilts), 90 (45 barrows and gilts), and 72 (36 barrows and 36 gilts) pigs with average weights of 9.8 +/- 1.62, 30.6 +/- 2.31, and 58.3 +/- 2.95 kg in the nursery, growing, and finishing stages, respectively, were assigned to three dietary treatments with six replicates in a randomized complete block design. The pigs had ad libitum access to water and fed three experimental diets, each supplemented with all indispensable AA and subjected to a 2% reduction in CP from the upper limits of 18%, 16%, and 16% established for the nursery, growing, and finishing stages, respectively. Results: In the nursery stage, from 0 to 2 weeks, reducing dietary CP concentrations decreased average daily feed intake (ADFI; linear, p = 0.04). From 2 to 4 weeks, dietary CP reduction decreased average daily gain (ADG; linear, p<0.01; quadratic, p = 0.02), ADFI (linear, p = 0.04), and gain-to-feed ratio (G:F; linear, p = 0.01). From 0 to 4 weeks, reduction in dietary CP concentrations decreased ADG (linear p<0.01), and G:F (linear, p = 0.01). In the growing stage, the dietary CP reduction did not affect growth performance. During the finishing stage, decrease in dietary CP concentrations decreased ADFI from 3 to 6 weeks (quadratic, p<0.01) and 0 to 6 weeks (quadratic, p = 0.01). Conclusion: Dietary CP reduction with indispensable AA supplementation potentially decreases the growth performance of nursery pigs but may not decrease the growth performance of growing and finishing pigs. ⓘ Cho, Inho; Kong, Changsu ⓘ Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea ⓘ ⓘ 58509432600; 36027521600 ⓘ changsukong@knu.ac.kr; ⓘ ANIMAL BIOSCIENCE ⓘ ANIM BIOSCI ⓘ 2765-0189 2765-0235 38 2 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2024 2.5 19.2 0 2025-05-07 ⓘ 0 0 Amino Acid; Low-protein Diet; Growth Performance; Growth Stage; Pig ⓘ DIGESTIVE ENZYMES; DIGESTIBILITY; METABOLISM; EXPRESSION; NITROGEN; HEALTH; SWINE ⓘ Amino Acid; Growth Performance; Growth Stage; Low-protein Diet; Pig ⓘ ⓘ English 2025 2025-02 10.5713/ab.24.0339 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Increased apoptosis in late-developing in vitro fertilized bovine blastocysts decreases successful pregnancy ⓘ Objective: Pregnancy in cattle after embryo transfer (ET) is influenced by several factors, including embryo quality. Therefore, preparing high quality embryos with the greatest developmental potential is essential for achieving a successful pregnancy after ET. Meanwhile, blastocysts produced by in vitro fertilization (IVF) procedure have different developmental speed during in vitro culture (IVC) and they exhibited different competence in the establishment of pregnancy. Methods: This study aimed to identify the comparative features of early, mid, and late developing bovine IVF blastocysts, when they first appeared at Day 7, 8, and 9 during IVC, respectively. In addition, the correlations between their molecular features and pregnancy ability were analyzed. Results: The results showed no difference in the morphological characteristics, including total cell count and diameter, between the Day 7, 8, and 9 blastocysts. However, the pregnancy rate post ET was significantly different between the groups at 51.7%, 36.7%, and 17.8% for Day 7, 8, and 9 blastocysts, respectively. During early embryo development, late developing blastocysts demonstrated a reduced cell count in the inner cell mass and decreased expression of the early embryo developmental genes (Oct4 and Sox2) compared with the early and mid developing blastocysts. In addition, the number of apoptotic cells and apoptosisrelated gene expression (increased Bax and decreased Bcl2) gradually elevated from the Day 7 to Day 9 blastocysts. However, there was no difference in mitochondrial activity and mitochondria relevant gene expression (Tfam and Cox1) between the groups. Correlation analysis identified a significantly negative correlation between the pregnancy rate and the blastocysts' degree of apoptosis, indicating that the low pregnancy ability of late developing blastocysts was mainly caused by increased apoptosis. Conclusion: This study's results may contribute to the field of animal biotechnology by assisting in establishing an improved strategy for bovine ET with IVF embryos. ⓘ Kim, Tae-Gyun; Choe, Yong-Ho; Kim, Sung-Ho; Lee, Sang-Yup; Jang, Min; Yun, Sung-Ho; Kim, Seung-Joon; Lee, Sung-Lim; Lee, Won-Jae ⓘ Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea; Bovivet, Gumi 39133, South Korea ⓘ ⓘ 59662453800; 57202927556; 57194701745; 59662600500; 59510648800; 57201366734; 55718678200; 16678898100; 57205486455 ⓘ iamcyshd@knu.ac.kr; ⓘ ANIMAL BIOSCIENCE ⓘ ANIM BIOSCI ⓘ 2765-0189 2765-0235 38 3 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2024 2.5 19.2 0 2025-05-07 ⓘ 1 1 Apoptosis; Bovine Blastocyst; Embryo Developmental Speed; Embryo Transfer; Hanwoo; Pregnancy Rate ⓘ GENE-EXPRESSION; EMBRYO-TRANSFER; PREIMPLANTATION; OOCYTES; CATTLE; BAX ⓘ Apoptosis; Bovine Blastocyst; Embryo Developmental Speed; Embryo Transfer; Hanwoo; Pregnancy Rate ⓘ ⓘ English 2025 2025-03 10.5713/ab.24.0454 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Inhibition of myotube formation by platelet-derived growth factor subunit B in QM7 cells ⓘ Objective: The primary objective of this study was to investigate the role and regulatory mechanisms of platelet-derived growth factor subunit B ( PDGFB ) in muscle differentiation. Methods: In this study, a vector for PDGFB was designed and transfected into quail muscle cells to investigate its role and regulatory mechanism during muscle formation. To investigate the inhibitory mechanisms of PDGFB on myogenic differentiation, the mRNA expression levels of various genes and the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2), both known to regulate muscle development and differentiation were compared. Results: PDGFB-overexpressed (OE) cells formed morphologically shorter and thinner myotubes and demonstrated a smaller total myotube area than did the control cells. This result was also confirmed at the molecular level by a reduced amount of myosin heavy chain protein in the PDGFB-OE cells. Therefore, PDGFB inhibits the differentiation of muscle cells. Additionally, the expression of myogenin ( MYOG ) significantly decreased in the PDGFB- OE cells on days 2 and 4 compared with that in the control cells. The phosphorylation of ERK 1/2, an upstream protein that inhibits MYOG expression, increased in the PDGFB-OE cells on day 4 compared with that in the control cells. The decreased expression of MYOG in the PDGFB-OE cells increased by inhibition ERK 1/2 phosphorylation. Conclusion: PDGFB may suppress myogenesis by reducing MYOG expression through ERK 1/2 phosphorylation. These findings can help understand muscle differentiation and potentially improve poultry meat production. ⓘ Choi, Sarang; Shin, Sangsu ⓘ Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea ⓘ ⓘ 59867032100; 55490360000 ⓘ sss@knu.ac.kr; ⓘ ANIMAL BIOSCIENCE ⓘ ANIM BIOSCI ⓘ 2765-0189 2765-0235 38 1 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2024 2.5 19.2 0 2025-05-07 ⓘ 0 0 Muscle Differentiation; Myoblast; Myogenesis; Platelet-derived Growth Factor Subunit B; QM7 Cell ⓘ MYOGENIC REGULATORY FACTORS; SKELETAL-MUSCLE; PDGF-BB; MYOBLAST PROLIFERATION; DIFFERENTIATION; ACTIVATION; EXPRESSION; INACTIVATION; REGENERATION; ISOFORMS ⓘ Muscle Differentiation; Myoblast; Myogenesis; Platelet-derived Growth Factor Subunit B; QM7 Cell ⓘ ⓘ English 2025 2025-01 10.5713/ab.24.0262 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Usefulness of Delta Neutrophil Index (DNI) for Prediction of 28 Day Mortality in Patients with Pneumonia-Induced Sepsis in the Intensive Care Unit ⓘ Background: The delta neutrophil index (DNI) represents the immature granulocyte fraction and is determined by subtracting the fraction of mature polymorphonuclear leucocytes from the sum of myeloperoxidase-reactive cells. The DNI has been proposed as a useful prognostic marker for sepsis. This study evaluated the clinical utility of DNI as a predictive marker in patients with pneumonia-induced sepsis in the intensive care unit (ICU). Methods: We conducted a retrospective study of pneumonia-induced sepsis in patients who were admitted to the Kangdong Sacred Heart Hospital's medical ICUs from July 2022 to March 2024. The DNI was measured on three consecutive days after ICU admission. The primary outcome of this study was a 28-day mortality. Results: A total of 227 patients with pneumonia-induced sepsis were included in this study. A 28-day mortality occurred 20.3% of the time in our study. In a univariate analysis, age (p = 0.05), lymphocyte (p = 0.02), DNI 1 (p = 0.01), DNI 2 (p = 0.00), DNI 3 (p = 0.00), and lactic acid (p = 0.00) were significantly associated with 28-day mortality. In a multivariable analysis, lactate (adj. OR: 0.86, 95% CI: 0.78-0.95, p = 0.002), and DNI 3 (adj. OR: 0.94, 95% CI: 0.89-0.99, p = 0.048) were significantly associated with 28-day mortality. In our study, the most appropriate cut-off values were DNI 1 (7.15), DNI 2 (8.9), and DNI 3 (2.6). Patients with higher DNI 3 (>= 2.6) showed higher 28-day mortality than patients with lower DNI 3 values of = 70 did not show statistically significantly different DNI 1 values between the survivor and non- survivor groups. Conclusions: The DNI at 72 h after ICU admission is a promising predictive prognostic marker of 28-day mortality in patients with pneumonia-induced sepsis in the ICU. However, the interpretation of the DNI in sepsis patients aged 70 and older on the first day of hospitalization should be approached with caution. ⓘ Moon, Sooyoon; Park, Yongbum; Hong, Chang-Won; Park, Sunghoon; Sim, Yunsu; Ko, Yousang; Park, Soyoung ⓘ Korea Univ, Guro Hosp, Dept Nephrol, Div Pulm Allergy & Crit Care Med, Seoul 08308, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Pulm Allergy & Crit Care Med, Seoul 05355, South Korea; Kyungpook Natl Univ, Dept Physiol, Daegu 41404, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Pulm Allergy & Crit Care Med, Dept Internal Med, Seoul 14068, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Pulm Allergy & Crit Care Med, Dept Internal Med,Coll Med, Seoul 07441, South Korea ⓘ Hong, Chang-Won/L-1272-2015 ⓘ 59713300800; 57208357131; 55567018400; 56117612300; 8879185900; 55353881500; 57203590410 ⓘ sundrop181@hanmail.net; bfspark2@gmail.com; cwhong@knu.ac.kr; f2000tj@naver.com; sysliver@naver.com; koyus@naver.com; sy.park12@gmail.com; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 6 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 0 2025-05-07 ⓘ 0 0 pneumonia-induced sepsis; septic shock; intensive care unit; twenty-eight-day mortality; delta neutrophil index ⓘ COMMUNITY-ACQUIRED PNEUMONIA; PROGNOSTIC MARKER; MANAGEMENT; DIAGNOSIS ⓘ delta neutrophil index; intensive care unit; pneumonia-induced sepsis; septic shock; twenty-eight-day mortality ⓘ lactic acid; aged; APACHE; Article; blood sampling; chronic obstructive lung disease; cohort analysis; comorbidity; controlled study; delta neutrophil index; diabetes mellitus; diagnostic test accuracy study; female; flow cytometry; granulocyte precursor; hospitalization; human; human cell; hypertension; intensive care unit; laboratory test; male; mortality; multivariate analysis; neutrophil; pneumonia; prediction; predictive value; prognosis; receiver operating characteristic; retrospective study; sensitivity and specificity; sepsis; septic shock; survivor; univariate analysis ⓘ English 2025 2025-03-15 10.3390/jcm14062002 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clinical Outcomes of Transradial Versus Transfemoral Approach in Rotational Atherectomy: Results from the Rotational Atherectomy in Calcified Lesions in Korea (ROCK) Registry ⓘ Background and Objectives: Rotational atherectomy (RA) is a crucial method for percutaneous coronary intervention (PCI) of heavily calcified coronary lesions. The aim of this study was to compare the clinical outcomes in patients undergoing RA via the radial versus femoral approach. Methods: The Rotational Atherectomy in Calcified Lesions in Korea (ROCK) registry included consecutive patients with severely calcified coronary artery disease who received RA during PCI at nine tertiary centers in Korea. A total of 540 patients who underwent PCI with RA were enrolled between October 2019 and January 2010. We retrospectively investigated the clinical outcomes between the transradial and transfemoral approaches. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE) within 36 months of follow-up. Results: Of the 540 patients, 248 patients (45.9%) were in the transradial group, and 292 patients (54.1%) were in the transfemoral group. There were no significant differences in MACCE (11.3% vs. 17.8%, adjusted hazard ratio [HR]: 1.520; 95% confidence interval: 0.889-2.600; p = 0.126) and procedural success (97.6% vs. 95.2%, p = 0.145). The occurrence of in-hospital bleeding was numerically higher in the transfemoral group, but the difference was not statistically significant (8 [3.2%] vs. 19 [6.5%], p = 0.081) Conclusions: In this study, the transradial approach did not show a significant difference in clinical outcomes but tended to have lower bleeding events compared to the transfemoral approach. RA via the transradial approach can be a useful vascular access option compared to the transfemoral approach. ⓘ Kim, Kyunyeon; Jung, Jin; Her, Sung-Ho; Lee, Kyusup; Jung, Ji-Hoon; Yoo, Ki-Dong; Moon, Keon-Woong; Moon, Donggyu; Lee, Su-Nam; Jang, Won-Young; Choi, Ik-Jun; Lee, Jae-Hwan; Lee, Jang-Hoon; Lee, Sang-Rok; Lee, Seung-Whan; Yun, Kyeong-Ho; Lee, Hyun-Jong ⓘ Catholic Univ Korea, St Vincents Hosp, Dept Cardiol, Seoul 16247, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Cardiol, Seoul 34943, South Korea; Korea Inst Toxicol, Daejeon 34114, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Cardiol, Incheon 21431, South Korea; Chungnam Natl Univ, Sch Med, Dept Cardiol Internal Med, Daejeon 35015, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu 41944, South Korea; Chonbuk Natl Univ Hosp, Dept Cardiol, Jeonju 54907, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Cardiol, Seoul 05505, South Korea; Wonkwang Univ Hosp, Reg Cardiocerebrovasc Ctr, Dept Cardiovasc Med, Iksan 54538, South Korea; Sejong Gen Hosp, Dept Internal Med, Bucheon 14754, South Korea ⓘ ; Yun, Kyeong Ho/IYS-8810-2023 ⓘ 59121391600; 57224923606; 59717022900; 57204923370; 57204175011; 35082999900; 7202376745; 56324177300; 57218696499; 57195753730; 55486997300; 36066387900; 59893100500; 59893288700; 17233718400; 59893100600; 59893479700 ⓘ gemini729@naver.com; colaking@naver.com; hhhsungho@naver.com; ajobi7121@gmail.com; jihoon.jung@kitox.re.kr; cardioyoo@gmail.com; cardiomoon@gmail.com; donggoo@catholic.ac.kr; yellow-night@hanmail.net; raph83@naver.com; mrfasthand@catholic.ac.kr; myheart@cnu.ac.kr; ljhmh75@knu.ac.kr; medorche@jbnu.ac.kr; seungwlee@amc.seoul.kr; dryunkh@gmail.com; untouchables00@hanmail.net; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 9 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 0 2025-06-11 ⓘ 0 0 atherectomy; mortality; hemorrhage; coronary vessels ⓘ PERCUTANEOUS CORONARY INTERVENTION; RADIAL ARTERY; ACCESS; ROTABLATOR; ANGIOPLASTY; STRATEGY ⓘ atherectomy; coronary vessels; hemorrhage; mortality ⓘ acetylsalicylic acid; anticoagulant agent; antithrombocytic agent; C reactive protein; hemoglobin; hemoglobin A1c; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; purinergic P2Y receptor antagonist; triacylglycerol; aged; all cause mortality; Article; body mass; cerebrovascular accident; cholesterol blood level; clinical outcome; comorbidity; controlled study; coronary artery bypass graft; coronary artery calcification; coronary artery dissection; coronary artery perforation; diabetes mellitus; disease severity; female; follow up; heart death; heart infarction; heart left ventricle ejection fraction; hemoglobin blood level; human; hypertension; in-hospital mortality; Korea; major clinical study; male; medical history; percutaneous coronary intervention; platelet count; postoperative complication; postoperative hemorrhage; prevalence; protein blood level; repeat procedure; retrospective study; rotational atherectomy; smoking; stent thrombosis; surgical approach; target vessel revascularization; triacylglycerol blood level ⓘ English 2025 2025-04-29 10.3390/jcm14093066 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Comparative Analysis of Anterolateral and Posterior Approaches for Distal Humerus Shaft Fractures: A Multicenter Retrospective Study ⓘ Background: Distal humeral shaft fractures (DHSFs) pose surgical challenges due to the proximity to the elbow joint, limited bone stock, and the risk of radial nerve injury. This study compared clinical and radiographic outcomes of anterolateral and posterior triceps-sparing approaches to determine the most effective surgical strategy. Methods: This multicenter retrospective study included 75 patients who underwent surgery for a DHSF between 2015 and 2021, with a minimum one-year follow-up, a distal fragment >= 3 cm, and no preoperative radial nerve injury. Fifty patients underwent anterior plating via anterolateral approach, and twenty-five underwent posterior plating. Clinical and radiographic outcomes were evaluated. Results: Bone union was achieved in 74 patients (98.7%), with no significant difference between the groups (p = 0.21). The anterolateral approach resulted in a shorter operative time (116 +/- 29.4 vs. 143 +/- 31.4 min, p = 0.03). However, intraoperative blood loss (p = 0.36), Mayo Elbow Performance Score (p = 0.71), range of motion (p = 0.36), and complication rates (p = 0.21) were not significantly different. Two cases of transient radial nerve palsy occurred in the posterior group (p = 0.17), and four cases required implant removal due to discomfort (p = 0.18) in the anterolateral group. Conclusions: Both approaches effectively treat DHSFs with high union rates and comparable functional outcomes. However, the anterolateral approach significantly reduces operative time due to supine positioning, direct access, and avoiding radial nerve dissection. Posterior plating remains viable when stable anterior fixation is unachievable. Further studies should assess the long-term outcomes and factors influencing approach selection. ⓘ Yoon, Yong-Cheol; Oh, Hyoung-Keun; Kim, Hyung-Suh; Kim, Joon-Woo ⓘ Gachon Univ, Coll Med, Trauma Ctr, Orthoped Trauma Div, Incheon 21565, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Orthoped Surg, Goyang 10380, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea ⓘ Yong-Cheol, Yoon/HPD-8077-2023 ⓘ 37082544400; 59870052100; 57215782121; 22951329000 ⓘ dryoonyc@gmail.com; ilsanosd11@gmail.com; 2103095@naver.com; joonwoo@knu.ac.kr; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 9 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 0 2025-06-11 ⓘ 0 0 distal humerus shaft fracture; anterolateral approach; posterior triceps-sparing approach; radial nerve; functional outcomes; bone union ⓘ PLATE; 3RD; MANAGEMENT; FIXATION ⓘ anterolateral approach; bone union; distal humerus shaft fracture; functional outcomes; posterior triceps-sparing approach; radial nerve ⓘ adult; Article; bleeding; comparative study; controlled study; distal humeral shaft fracture; distal humerus; female; follow up; fracture healing; human; human experiment; humerus fracture; humerus shaft fracture; informed consent; institutional review; major clinical study; male; Mayo Elbow Performance Score; medical history; middle aged; minimally invasive procedure; multicenter study; nerve injury; open fracture; operation duration; radial nerve; radial nerve injury; radial nerve palsy; retrospective study; smoking; sport injury; surgical approach; traffic accident ⓘ English 2025 2025-04-22 10.3390/jcm14092890 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Comparison of Hidden Blood Loss in Biportal Endoscopic Spine Surgery and Open Surgery in the Lumbar Spine: A Retrospective Multicenter Study ⓘ Background/Objectives: Biportal endoscopic spine surgery (BESS) is one of the minimally invasive spine surgery techniques. BESS has several advantages, such as better visualization, less muscle injury, early rehabilitation, etc. Due to its clear visualization, delicate intraoperative hemostasis of the bleeding foci, including cancellous bone and small epidural vessels, can be achieved. Therefore, some authors have reported that BESS resulted in less intraoperative visible blood loss (VBL) compared to conventional open surgery. However, it is difficult to analyze the exact amount of intraoperative blood loss because of the continuous normal saline irrigation. In addition, hidden blood loss (HBL) tends to be overlooked, and the amount of HBL might be larger than expected. We aim to calculate the amount of HBL during BESS and to compare our findings with convention open surgery. Methods: We retrospectively obtained the clinical data of patients that underwent lumbar central decompression from July 2021 to June 2024. Patients were divided into two groups: the BESS group that underwent biportal endoscopic lumbar decompression, and the open surgery group that underwent open decompression. Both groups used unilateral laminotomy and bilateral decompression techniques. Total blood loss (TBL) using preoperative and postoperative change in hematocrit (Hct) was measured using Gross's formula and the Nadler equation. Since TBL consists of VBL and HBL, HBL was calculated by subtracting the VBL measured intraoperatively from TBL. Results: A total of sixty-six patients in the BESS group and seventeen patients in the open surgery group were included in the study. The TBL was 247.16 +/- 346.88 mL in the BESS group and 298.71 +/- 256.65 mL in the open surgery group, without significant difference (p = 0.569). The calculated HBL values were 149.44 +/- 344.08 mL in the BESS group and 171.42 +/- 243.93 mL in the open surgery group. The HBL in the BESS group was lower than the HBL in the open surgery group, without significant difference (p = 0.764). Conclusions: The TBL and HBL during lumbar central decompression were smaller in patients who underwent BESS compared to those who underwent open surgery. While TBL was significantly lower in BESS, HBL did not show statistical significance between the two groups. HBL during BESS should not be neglected, and related hemodynamics should be considered postoperatively. ⓘ Kim, Dae-Geun; Park, Eugene J.; Min, Woo-Kie; Kim, Sang-Bum; Lee, Gaeun; Choi, Sung ⓘ Soonchunhyang Univ, Coll Med, Gumi Hosp, Dept Orthoped Surg, Gumi 39568, South Korea; Dream Gen Hosp, Dept Orthoped Surg, Daegu 702752, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Coll Med, Dept Orthoped Surg, Daegu 41944, South Korea; Bogang Hosp, Spine Ctr, Daegu 42801, South Korea; Chungnam Natl Univ, Sejong Chungnam Natl Univ Hosp, Dept Orthoped Surg, Coll Med, Daejeon 30099, South Korea; Soonchunhyang Univ, Div Biostat, Gumi Hosp, Gumi 39568, South Korea; Daegu Fatima Hosp, Dept Orthoped Surg, Daegu 41199, South Korea ⓘ Kim, Dae-Geun/JMQ-2583-2023; Park, Eugene/P-1473-2018 ⓘ 57212252301; 55371642100; 8548041000; 57195935883; 58692232500; 57208204262 ⓘ kuroo25@schmc.ac.kr; pjj841229@gmail.com; oswkmin@gmail.com; sangbumos@icloud.com; 20240236@schmc.ac.kr; oschoisung@gmail.com; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 11 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 N/A ⓘ 0 0 spine surgery; open surgery; biportal endoscopic spine surgery; hidden blood loss ⓘ INTERBODY FUSION; DECOMPRESSION ⓘ biportal endoscopic spine surgery; hidden blood loss; open surgery; spine surgery ⓘ anticoagulant agent; adult; aged; Article; biportal endoscopic spine surgery; bleeding; comparative study; decompression surgery; endoscopic surgery; female; hematocrit; hemodynamics; hemostasis; human; laminotomy; lumbar spine; major clinical study; male; minimally invasive spine surgery; multicenter study; multicenter study (topic); open surgery; retrospective study; spine surgery; surgical technique; trabecular bone ⓘ English 2025 2025-05-30 10.3390/jcm14113878 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Effect of carbon nanotubes on shear behavior of PVA-ECC beams ⓘ This study experimentally verified the effect of adding carbon nanotubes (CNTs) on the shear behavior of polyvinyl alcohol-engineered cementitious composites (PVA-ECC) beams without shear reinforcement at different longitudinal reinforcement ratios and shear span-to-depth (a/d) ratios. The test results indicated that CNTs addition significantly enhanced the shear capacity, showing an improvement of up to 15 % in tests with a variable longitudinal reinforcement ratio and up to 33 % in tests with a variable shear span-to-depth ratio. Furthermore, in load-deflection responses, the initial stiffness increased for all variables due to CNTs addition. However, the test results of some specimens indicated that CNTs addition increased the uncertainty associated with the material properties of PVA-ECC. The uncertainty is considered to require incorporation into safety factors in the design process through further research. The test results were compared with the shear capacities predicted by fib Model Code 10 (MC10), fib Model Code 20 (MC20), and the equations proposed in previous studies. The investigation revealed that MC20 showed the most reasonable prediction in this study. ⓘ Lee, Dongmin; Park, Seong-Hyun; Sim, Yeonhui; Kwon, Oh-Sung; Lee, Seong-Cheol ⓘ Kyungpook Natl Univ, Dept Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Toronto, Dept Civil & Mineral Engn, 35 St George St, Toronto, ON M5S 1A4, Canada ⓘ Kwon, Oh-Sung/ABB-6825-2020 ⓘ 57670923900; 59529199200; 59529493200; 56459431700; 35784449900 ⓘ knucon@naver.com; qsh858@naver.com; simyeonhui@gmail.com; os.kwon@utoronto.ca; seonglee@knu.ac.kr; ⓘ STRUCTURES ⓘ STRUCTURES ⓘ 2352-0124 72 SCIE ENGINEERING, CIVIL ⓘ 2024 4.3 19.4 0 2025-05-07 ⓘ 1 1 Carbon nanotubes; Shear behavior; PVA fiber; Cementitious composites; Shear ⓘ REINFORCED CEMENTITIOUS COMPOSITES; MECHANICAL PERFORMANCE; STEEL FIBERS; STRENGTH; MICROSTRUCTURE; WORKABILITY ⓘ Carbon nanotubes; Cementitious composites; PVA fiber; Shear; Shear behavior ⓘ Carbon carbon composites; Shear stress; Cementitious composites; Composite beam; Engineered cementitious composites; Longitudinal reinforcement; Polyvinyls; PVA fiber; Reinforcement ratios; Shear; Shear behaviour; Shear capacity; Safety factor ⓘ English 2025 2025-02 10.1016/j.istruc.2025.108243 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ In-plane shear strength models of masonry walls strengthened with steel-bar truss units ⓘ This study presented shear strength models for evaluating the seismic performance and designing masonry walls strengthened with steel-bar truss units (STUs). As an unbonded reinforcement method, STUs comprised vertical bars, diagonal bars, and horizontal bars through anchorages. The shear strength model was developed based on regression analysis using cyclic loading tests and nonlinear finite element analysis (FEA) results of reinforced masonry (RM) walls strengthened with STUs. The FEA was conducted based on the experimental data provided by Hwang et al. (2020, 2022b) and showed similar results regarding failure mode, load-displacement relationship, and shear strength. Additionally, FEA was performed for 28 unreinforced masonry (URM) walls and 44 RM walls, considering various factors such as the geometry of the masonry wall, door openings, mortar plasters, and the amount of reinforcement. The shear strength model for RM walls was developed by combining the URM walls' strength model and the presented STUs' load contribution. It was noted that the proposed shear strength models tended to overestimate rocking strength but showed similar results to the experiment for peak strength. ⓘ Hwang, Seung-Hyeon; Kim, Sanghee; Mun, Ju-Hyun; Yang, Keun-Hyeok; Lee, Dong-Eun ⓘ Korea Inst Civil Engn & Bldg Technol KICT, Dept Struct Engn Res, Goyang, South Korea; Kyonggi Univ, Dept Architectural Engn, Suwon 16227, Kyonggi, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea ⓘ Kim, Sanghee/KHX-8168-2024; Mun, Ju-Hyun/ISB-3859-2023 ⓘ 57214753542; 56577087300; 39862004200; 7404291695; 56605563300 ⓘ shhwang@kict.re.ke; sanghee0714@kyonggi.ac.kr; mjh@kgu.ac.kr; yangkh@kgu.ac.kr; dolee@knu.ac.kr; ⓘ STRUCTURES ⓘ STRUCTURES ⓘ 2352-0124 71 SCIE ENGINEERING, CIVIL ⓘ 2024 4.3 19.4 0 2025-05-07 ⓘ 0 0 Masonry wall; Shear strength; Steel-bar truss units; Finite element analysis; Rocking strength ⓘ SEISMIC PERFORMANCE; BEHAVIOR ⓘ Finite element analysis; Masonry wall; Rocking strength; Shear strength; Steel-bar truss units ⓘ Anchorages (concrete construction); Bars (metal); Brick construction; Cyclic loads; Masonry materials; Seismic design; Shear strength; Shear walls; Bar truss; Finite element analyse; Masonry walls; Reinforced masonry walls; Rocking strength; Shears strength; Steel bars; Steel-bar truss unit; Strength models; Un-reinforced masonry walls; Trusses ⓘ English 2025 2025-01 10.1016/j.istruc.2024.108041 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Radiomics Models to Predict Tumor Response and Pneumonitis in Non-Small Cell Lung Cancer Patients Treated with Immunotherapy ⓘ Background: Checkpoint inhibitor-associated pneumonitis (CIP) after immunotherapy has become a challenging issue in non-small cell lung cancer (NSCLC) patients. This study leverages artificial intelligence (AI) algorithms to analyze radiomic features, aiming to predict the occurrence of CIP, as well as tumor response. Methods: This study analyzed data from 159 stage III-IV NSCLC patients undergoing immunotherapy. The patients were categorized into pneumonitis and non-pneumonitis groups, and 3D radiomic features from both tumors and surrounding regions were extracted using LIFEx software. To address scanner-associated variations, a linear mixed-effect radiomics harmonization model was applied. A random forest algorithm was then used to develop models predicting CIP occurrence and tumor responses based on the pre-treatment CT radiomics. The accuracy was evaluated using the area under the curve (AUC). Results: A total of 159 patients were analyzed, of which only 31 experienced CIP. Most had grade 1 (17/31, 54.8%) or 2 (12/31, 38.7%) pneumonitis; only two (6.5%) patients had grade 3. Patients who developed pneumonitis were more likely to be male (64.5% vs. 38.3%, p = 0.014), had less adenocarcinoma histology (54.8% vs. 78.9%, p = 0.032), and exhibited a higher tumor mutational burden (57.1% vs. 24.5%, p = 0.047). Radiomics analysis reported predictability for CIP with an AUC of 0.60 (95% CI 0.55-0.66). The five-year overall and progression-free survival rates were 24.7% (95% CI 15.2-35.5%) and 9.7% (95% CI 4.4-17.4%), respectively. The radiomics features also exhibited AUCs of 0.63 (95% CI 0.59-0.67) in irRECIST and 0.66 (95% CI 0.61-0.70) in RECIST 1.1 in terms of tumor responses to immunotherapy. Conclusions: This study provides insights into the potential role of radiomic models in predicting CIP and tumor responses from pre-treatment CT images of NSCLC patients treated with immunotherapy. ⓘ Yadav, Monica; Woo, Wongi; Chae, Young Kwang; Lee, Jeeyeon; Kim, Peter Haseok; Lee, Seyoung; Um, Taegyu; Lee, Salie; Chuchuca, Maria Jose Aguilera; Djunadi, Trie Arni; Chung, Liam Il-Young; Yu, Jisang; Gennaro, Nicolo; Kim, Leeseul; Nam, Myungwoo; Oh, Youjin; Yoon, Sungmi; Shah, Zunairah; Kim, Yuchan; Hong, Ilene; Jang, Jessica; Kang, Grace; Cho, Amy; Lee, Soowon; Hong, Timothy; Nam, Cecilia; Velichko, Yury S. ⓘ Northwestern Univ, Feinberg Sch Med, NMH Arkes Family Pavilion,Suite 800,676 N St Clair, Chicago, IL 60611 USA; St Josephs Med Ctr, 1800 N Calif St, Stockton, CA 95204 USA; Kyungpook Natl Univ, Dept Breast Surg, Daegu 37224, South Korea; Univ Texas Austin, Dept Biochem, Austin, TX 78712 USA; Sch Med UCI, Div Pulm Dis & Crit Care Med, Irvine, CA 92617 USA; Richmond Univ, Med Ctr, Staten Isl, NY 10310 USA; Dign Hlth St Rose Dominican Hosp, Henderson, NV USA; Ascens St Francis Hosp, Evanston, IL 60202 USA; Lincoln Med Ctr, Bronx, NY 10451 USA; Jr Hosp Cook Cty, Chicago, IL 60612 USA; Roswell Pk Comprehens Canc Ctr, Buffalo, NY 14203 USA; Northwestern Univ, Evanston Campus, Evanston, IL 60208 USA; Johns Hopkins Bloomberg Sch Publ Hlth, Dept Global Dis Epidemiol & Control, Baltimore, MD USA ⓘ Gennaro, Nicolò/P-1776-2019; Chung, Liam Il-Young/IQU-0821-2023 ⓘ 59490428100; 57190048534; 59914852500; 37079213100; 59490212100; 59491061700; 59490211900; 59963510700; 58536910800; 58019543600; 58018988700; 59963957700; 57204113955; 57219467939; 57225054101; 58461465600; 58019402300; 36817286700; 59962825400; 58019264000; 59359047900; 59359442000; 59963510800; 58891221400; 58892357400; 59963510900; 6701545596 ⓘ monicay142@gmail.com; wongi.woo@commonspirit.org; YCHAE@nm.org; j.lee@knu.ac.kr; hkim20919@gmail.com; seyoung.b.lee@gmail.com; alfred20@naver.com; md.s.lee.511@gmail.com; mariajose.aguilera.md@gmail.com; tdjunadi@rumcsi.org; eureka10chung@yahoo.com; jisangyu.md@gmail.com; nicolo.gennaro@northwestern.edu; leeseul.kim@uchicagomedicine.org; oujin0521@gmail.com; sungmiyoon1@gmail.com; zunairahs.zs@gmail.com; willkim012@gmail.com; ilenehong2024@u.northwestern.edu; jessicajjang11@gmail.com; gracekang2025@u.northwestern.edu; yubeencho2025@u.northwestern.edu; slee623@jh.edu; timjisukhong@gmail.com; cecilianam2025@u.northwestern.edu; y-velichko@northwestern.edu; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 12 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 ⓘ 0 0 radiomics; immunotherapy; lung cancer; pneumonitis ⓘ ⓘ immunotherapy; lung cancer; pneumonitis; radiomics ⓘ ⓘ English 2025 2025-06-18 10.3390/jcm14124330 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Reliability of Tracheal Temperature as a Measurement of Core Body Temperature During Cardiac Surgery Using Cardiopulmonary Bypass ⓘ Background: To compare tracheal temperature (TET) with nasopharyngeal temperature (TNP) in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Methods: TET was measured using a thermistor in the cuff of an endotracheal tube and TNP was monitored using an esophageal stethoscope. Depending on the management of the CPB strategy, the operation was divided into four periods (pre-CPB, cooling, rewarming, and post-CPB). A Bland-Altman analysis was carried out to compare TET with TNP in each period. The concordance correlation coefficient for repeated measures analysis and various time lags was used to validate the time lag maximizing the concordance correlation coefficient between the two methods. Results: A total of 7191 pairs of temperature recordings acquired from 24 patients were included in the analysis. During steady normothermia, 81.7% (95% confidence interval [CI], 79.8-83.5%) of the pairs had a difference within +/- 0.5 degrees C, with a mean bias of -0.28 degrees C and limits of agreement (LOA) of -0.74 degrees C to 0.18 degrees C. The LOA during the cooling and rewarming phase of CPB were -1.13 degrees C to 0.51 degrees C and -0.91 degrees C to 1.29 degrees C, respectively. The mean bias and LOA throughout the entire operation were -0.10 degrees C and -0.98 degrees C to 0.77 degrees C, respectively. Throughout the entire operation, -2 min of time lag on TET maximized the concordance correlation coefficient (0.94 [95% CI, 0.92-0.96] to 0.95 [95% CI, 0.93-0.96]), indicating an earlier response of TET than TNP. Conclusions: TET could be an alternative to TNP during cardiac surgery using CPB. ⓘ Kang, Hyun-Uk; Lee, Sou-Hyun; Chin, Ji-Hyun; Choi, In-Cheol; Kim, Kyungmi ⓘ Univ Ulsan, Coll Med, Asan Med Ctr, Dept Anesthesiol & Pain Med, Seoul 05505, South Korea; Kyungpook Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daegu 41944, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Anesthesiol & Pain Med, Seoul 02841, South Korea ⓘ ⓘ 57190275573; 57223957892; 26434597200; 8699220700; 57200729870 ⓘ hyunuk_kang@naver.com; youlion6@gmail.com; cjh@amc.seoul.kr; icchoi@amc.seoul.kr; kyungmi_kim@korea.ac.kr; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 2 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 0 2025-05-07 ⓘ 0 0 body temperature; monitoring; cardiac surgery; cardiopulmonary bypass ⓘ NASOPHARYNGEAL TEMPERATURE; GUIDELINES ⓘ body temperature; cardiac surgery; cardiopulmonary bypass; monitoring ⓘ adult; aged; Article; body temperature; body temperature monitoring; cardiopulmonary bypass; clinical article; cohort analysis; comparative study; controlled study; core temperature; female; heart disease; heart surgery; human; male; observational study; temperature measurement; trachea ⓘ English 2025 2025-01 10.3390/jcm14020632 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ The Crucial Role of the Blood-Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications ⓘ The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from the bloodstream into the central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's and Parkinson's disease, as well as ischemic stroke, compromise the integrity of the BBB. This leads to increased permeability and the infiltration of harmful substances, thereby accelerating neurodegeneration. In this review, we explore the mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, and the loss of tight junction integrity, in patients with neurodegenerative diseases. We discuss how BBB breakdown contributes to neuroinflammation, neurotoxicity, and the abnormal accumulation of pathological proteins, all of which exacerbate neuronal damage and facilitate disease progression. Furthermore, we discuss potential therapeutic strategies aimed at preserving or restoring BBB function, such as anti-inflammatory treatments, antioxidant therapies, and approaches to enhance tight junction integrity. Given the central role of the BBB in neurodegeneration, maintaining its integrity represents a promising therapeutic approach to slow or prevent the progression of neurodegenerative diseases. ⓘ Kim, Sehwan; Jung, Un Ju; Kim, Sang Ryong ⓘ Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41404, South Korea ⓘ ⓘ 57193232250; 7007119425; 56486163800 ⓘ arputa@naver.com; jungunju@naver.com; srk75@knu.ac.kr; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 2 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 12.5 2025-05-07 ⓘ 7 7 blood-brain barrier; neurodegenerative diseases; oxidative stress; neuroinflammation; neurotoxicity ⓘ NECROSIS-FACTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; FOCAL CEREBRAL-ISCHEMIA; TIGHT JUNCTION PROTEINS; NF-KAPPA-B; OXIDATIVE STRESS; BASEMENT-MEMBRANE; P-GLYCOPROTEIN; ALZHEIMER-DISEASE; MITOCHONDRIAL DYSFUNCTION ⓘ blood–brain barrier; neurodegenerative diseases; neuroinflammation; neurotoxicity; oxidative stress ⓘ Alzheimer disease; blood brain barrier; central nervous system; degenerative disease; drug therapy; etiology; homeostasis; human; male; nerve degeneration; nervous system inflammation; neurotoxicity; nonhuman; oxidative stress; Parkinson disease; pharmacology; review; vascularization ⓘ English 2025 2025-01 10.3390/jcm14020386 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The Impact of Vascular Anatomic Variations in the Infra-Pyloric Area on the Surgical Outcomes of Laparoscopic Pylorus-Preserving Gastrectomy in Early Gastric Cancer: A Post Hoc Analysis of a Multicenter Prospective Trial (KLASS-04) ⓘ Background/Objectives: During laparoscopic pylorus-preserving gastrectomy (LPPG), the preservation of the infra-pyloric artery (IPA) and dissection of the infra-pyloric lymph node (LN) station 6 are essential, underscoring the importance of understanding the anatomical structure of the IPA. This study aimed to investigate anatomical variations in the IPA and surgical outcomes based on data from a multicenter prospective trial. Methods: A post hoc analysis was conducted based on the Korean Laparoendoscopic Gastrointestinal Surgery Study (KLASS)-04 trial, in which patients randomly underwent LPPG or laparoscopic distal gastrectomy (LDG). The IPA variations were categorized into three groups: distal, caudal, and proximal. Clinicopathological characteristics and surgical outcomes were analyzed according to the IPA type. Results: Among the 192 patients, the distribution of IPA types was as follows: 45 (23.44%) distal, 74 (38.54%) caudal, and 73 (38.02%) proximal. There were no significant differences in the clinicopathological characteristics between the IPA types. Of the 119 patients who underwent LPPG, a significant difference in operative time was observed based on the IPA type, with a longer duration observed with the distal type compared to that of the proximal type (distal type vs. proximal type: 202.5 (150-275) vs. 170 (105-265) min, p = 0.0300). No significant differences were observed in other surgical outcomes. Conclusions: The distribution of IPA types was more diverse than that reported in previous studies. There was a statistically significant difference in the operating time based on the IPA type. Identifying IPA variations during LPPG may be beneficial for gastric cancer surgeons. ⓘ Eom, Sang Soo; Park, Sin Hye; Rhee, Young Shick; Kim, Sa-Hong; Lee, Hyuk-Joon; Kim, Young-Woo; Yang, Han-Kwang; Park, Do Joong; Han, Sang Uk; Kim, Hyung-Ho; Hyung, Woo Jin; Park, Ji-Ho; Suh, Yun-Suhk; Kwon, Oh-Kyung; Kim, Wook; Park, Young-Kyu; Yoon, Hong Man; Ahn, Sang-Hoon; Kong, Seong-Ho; Ryu, Keun Won ⓘ Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Surg, Goyang 10380, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Gastrointestinal Surg, Seoul 06591, South Korea; Natl Canc Ctr, Ctr Gastr Canc, 323 Ilsan Ro, Goyang 10408, South Korea; Seoul Natl Univ Hosp, Dept Surg, Seoul 03080, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Surg, Seoul 03080, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Canc Res Inst, Coll Med, Seoul 03080, South Korea; Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul 03080, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Surg, Seongnam 13620, South Korea; Ajou Univ Hosp, Dept Surg, Suwon 16499, South Korea; Yonsei Univ, Severance Hosp, Dept Surg, Seoul 03722, South Korea; Gyeongsang Natl Univ Hosp, Dept Surg, Daegu 52727, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu 41566, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Dept Surg, Seoul 14662, South Korea; Chonnam Natl Univ, Med Sch, Dept Surg, Hwasun 58128, South Korea ⓘ Yang, Han/H-2458-2016 ⓘ 57413816300; 54414695000; 59732235300; 57211339922; 7501481303; 57215377843; 7406557280; 14319341400; 35798267700; 57222879336; 6602139318; 57202928322; 39062470900; 26536109900; 57219776830; 10140547300; 35735626600; 59953256100; 57226519368; 55667555300 ⓘ docryu@ncc.re.kr; ⓘ JOURNAL OF CLINICAL MEDICINE ⓘ J CLIN MED ⓘ 2077-0383 14 7 SCIE MEDICINE, GENERAL & INTERNAL ⓘ 2024 2.9 19.4 0 2025-05-07 ⓘ 0 0 gastrectomy; gastric cancer; pylorus ⓘ LYMPH-NODES; ARTERY ⓘ gastrectomy; gastric cancer; pylorus ⓘ adult; aged; anatomical concepts; anatomical variation; anterior superior pancreaticoduodenal artery; Article; blood vessel; clinical feature; clinical outcome; controlled study; early cancer; female; gastroduodenal artery; human; infrapyloric artery; Korea; laparoscopic distal gastrectomy; major clinical study; male; multicenter study (topic); operation duration; outcome assessment; post hoc analysis; prospective study; pylorus; pylorus-preserving gastrectomy; randomized controlled trial (topic); right gastroepiploic artery; statistical significance; stomach cancer; superior mesenteric artery ⓘ English 2025 2025-04-07 10.3390/jcm14072508 ⓘ 바로가기 바로가기 바로가기 바로가기
페이지 이동: