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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | miRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia | Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-kappa B and p38 MAPK pathways in spinal microglia. Materials & methods: After NP preparation, miR NPs were assessed for their physical characteristics and then injected intrathecally into the spinal cords of rat spinal nerve ligation rats to test their analgesic effects. Results: miR NPs reduced pain behaviors for 11 days by negatively regulating the inflammatory response in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain. | Thuy Linh Pham; Yin, Yuhua; Kwon, Hyeok Hee; Shin, Nara; Kim, Song, I; Park, Hyewon; Shin, Juhee; Shin, Hyo Jung; Hwang, Jeong-Ah; Song, Hee-Jung; Kim, Sang Ryong; Lee, Joo Hyoung; Hwang, Patrick T. J.; Jun, Ho-Wook; Kim, Dong Woon | Chungnam Natl Univ, Dept Med Sci, Coll Med, Daejeon 35015, South Korea; Chungnam Natl Univ, Brain Res Inst, Dept Anat & Cell Biol, Coll Med, Daejeon 35015, South Korea; Guangzhou Women & Childrens Med Ctr, Dept Anesthesia, Guangzhou 510623, Guangdong, Peoples R China; Chungnam Natl Univ, Brain Res Inst, Dept Neurol, Coll Med, Daejeon 35015, South Korea; Kyungpook Natl Univ, Sch Life Sci, Inst Life Sci & Biotechnol, Brain Sci & Engn Inst,BK21 Plus KNU Creat BioRes, Daegu 41566, South Korea; Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA; Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA | ; Lee, Jae Min/H-8475-2013; lee, hy/GRS-0797-2022 | 59073504400; 57194577241; 57189320537; 56699607100; 57215210216; 57203117596; 57206624978; 57195753989; 57215200331; 26535323600; 56486163800; 59289288100; 55892288500; 7101976138; 57204150578 | hwjun@uab.edu;visnu528@cnu.ac.kr; | NANOMEDICINE | NANOMEDICINE-UK | 1743-5889 | 1748-6963 | 15 | 11 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.307 | 18.6 | 1.39 | 2025-06-25 | 20 | 23 | microglia; miRNA 146a-5p; neuropathic pain; PLGA nanoparticles | NF-KAPPA-B; SPINAL NERVE LIGATION; NEUROPATHIC PAIN; MICRORNA-146A; EXPRESSION; PATHOGENESIS; INDUCTION; CYTOKINES; MORPHINE; ALPHA | microglia; miRNA 146a-5p; neuropathic pain; PLGA nanoparticles | Animals; Glycolates; Glycols; Lactic Acid; Microglia; MicroRNAs; Nanoparticles; Neuralgia; Rats; Rats, Sprague-Dawley; immunoglobulin enhancer binding protein; microRNA; microRNA 146a 5p; mitogen activated protein kinase p38; nanoparticle; polyglactin; unclassified drug; glycol; glycolic acid; lactic acid; microRNA; analgesic activity; animal behavior; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; controlled study; immunohistochemistry; male; microglia; neuropathic pain; nonhuman; priority journal; rat; rat model; regulatory mechanism; spinal cord; spinal nerve ligation injury; Sprague Dawley rat; von Frey test; animal; genetics; microglia; neuralgia | English | 2020 | 2020-05 | 10.2217/nnm-2019-0462 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Rifampicin-loaded nanotransferosomal gel for treatment of cutaneous leishmaniasis: passive targeting via topical route | Aim: In this study, the targeting of rifampicin (RIF)-loaded nanotransfersomes (NTs) incorporated in chitosan gel for leishmania-infected macrophages via the topical route was investigated. Materials & methods: NTs were prepared through a thin-film hydration process and incorporated into chitosan gel. Results: The mean particle size of the NTs was 190 nm, with 83% encapsulation efficiency. The permeation rate of the NTs was threefold higher than that of the RIF solution. The NTs improved cellular internalization via passive targeting, which was confirmed by macrophage uptake evaluation. A low IC50 value, flow cytometry analysis and in vivo study demonstrated the RIF-loaded NTs enhanced apoptosis and had better antileishmanial effects. Conclusion: RIF-loaded NT gel could be a fitting carrier for the delivery of antileishmanial drugs in cutaneous leishmaniasis. | Rabia, Samreen; Khaleeq, Nadra; Batool, Sibgha; Dar, Muhammad Junaid; Kim, Dong Wuk; Din, Fakhar-Ud; Khan, Gul Majid | Quaid I Azam Univ, Dept Pharm, Islamabad 45230, Pakistan; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea | Dar, M. Junaid/ITU-9556-2023; Din, Fakhar Ud/AAR-1034-2020; KHAN, GUL MAJID/G-5739-2011; Din, Fakhar-Ud-/AAR-1034-2020; Khan, Gul Majid/G-5739-2011; Batool, Sibgha/HTS-0477-2023 | fudin@qau.edu.pk;gmkhan@qau.edu.pk; | NANOMEDICINE | NANOMEDICINE-UK | 1743-5889 | 1748-6963 | 15 | 2 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.307 | 18.6 | 62 | cellular internalization; flow cytometry; IC50; leishmaniasis; nanotransfersomes; passive targeting; permeation rate; thin film hydration | TRANSDERMAL DRUG-DELIVERY; IN-VITRO; ULTRADEFORMABLE VESICLES; DEFORMABLE LIPOSOMES; FORMULATION DESIGN; SKIN DELIVERY; TRANSFERSOMES; CARRIERS; EFFICACY; NANOPARTICLES | English | 2020 | 2020-01 | 10.2217/nnm-2019-0320 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Investigating the Optimal Location of Potential Forest Industry Clusters to Enhance Domestic Timber Utilization in South Korea | South Korea has abundant forest resources capable of supplying the domestic wood demand. Despite the extensive forest resources, there is continued uncertainty about the nature, quantity, and quality of the timber contained in any particular forested area. Additionally, some technical, logistic, and economic challenges act as barriers to the expansion of domestic timber utilization. To overcome these limitations and to enhance the domestic timber utilization in South Korea, this study investigated the optimal location of potential forest industry clusters. The potential forest availability was estimated based on localized allometric equations. The integration of the analytical hierarchy process and GIS modeling, including a supply chain that minimizes transportation costs, allowed the identification of optimal forest industry clusters locations that balanced the economic, environmental, and social dimensions within the forest industry supply chain. The study reveals that the estimated potential forest resources availability presented approximately 1 billion m(3), including sawlog (474 million m(3)) and pulpwood grade (541 million m(3)). Additionally, 45 percent of the sawlogs and 48 percent of the pup grade wood were produced from the Gangwon and Gyeongsangbuk-do regions. Furthermore, the logistic analysis indicates that ten potential forest industry clusters are best aligned with the optimal socio-economic impacts with minimized timber transportation costs. To identify the optimal size and number of potential forest industry clusters, further studies that consider fixed and variable costs for maintaining the forest industry clusters are required. | Woo, Heesung; Han, Hee; Cho, Seungwan; Jung, Geonhwi; Kim, Bomi; Ryu, Jiyeon; Won, Hyun Kyu; Park, Joowon | Kyungpook Natl Univ, Sch Forest Sci & Landscape Architecture, Coll Agr & Life Sci, Daegu 41566, South Korea; Natl Inst Forest Sci, Dept Forest Policy & Econ, Seoul 02445, South Korea; Chungnam Forest Environm Res Inst, 110 Sanrimbakmulgwan Gil, Sejong Special Self Gove 30085, South Korea | Woo, Heesung/AAG-4028-2020 | 57203973789; 55974809700; 57208123603; 57219031456; 57219031676; 57219028373; 56438974400; 55791550500 | whs1608@gmail.com;hkwon@korea.kr;one5639@knu.ac.kr;alzaki3050@knu.ac.kr;bm0901@korea.kr;yns991022@knu.ac.kr;joowon72@knu.ac.kr;heehan@korea.kr; | FORESTS | FORESTS | 1999-4907 | 11 | 9 | SCIE | FORESTRY | 2020 | 2.634 | 18.7 | 0.68 | 2025-06-25 | 9 | 11 | forest industry clusters; optimal location; forest supply chain; domestic timber utilization; forest biomass | RENEWABLE ENERGY-SOURCES; BIOENERGY FACILITIES; BIOMASS; GIS; RESOURCES | Domestic timber utilization; Forest biomass; Forest industry clusters; Forest supply chain; Optimal location | Costs; Forestry; Natural Resources; South Korea; Cost benefit analysis; Forestry; Location; Natural resources; Supply chains; Timber; Allometric equations; Analytical Hierarchy Process; Economic challenges; Logistic analysis; Social dimensions; Socio-economic impacts; Timber transportation; Transportation cost; analytical hierarchy process; biomass; forest resource; GIS; logistics; socioeconomic impact; supply chain management; timber industry; Costs | English | 2020 | 2020-09 | 10.3390/f11090936 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nonmuscle myosin IIB regulates Parkin-mediated mitophagy associated with amyotrophic lateral sclerosis-linked TDP-43 | C-terminal fragments of Tar DNA-binding protein 43 (TDP-43) have been identified as the major pathological protein in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, how they affect cellular toxicity and neurodegeneration, including the modulation process remains unknown. This study revealed that the C-terminal fragment of TDP-43 (TDP-25) was localized primarily to mitochondria and caused abnormal mitochondrial morphology, inducing Parkin-mediated mitophagy. Also, we discovered that the knockdown of selective autophagy receptors, such as TAX1BP, Optineurin, or NDP52 caused TDP-25 accumulation, indicating that TDP-25 was degraded by mitophagy. Interestingly, myosin IIB, a nonmuscle type of myosin and actin-based motor protein, is mostly colocalized to TDP-25 associated with abnormal mitochondria. In addition, myosin IIB inhibition by siRNA or blebbistatin induced mitochondrial accumulation of insoluble TDP-25 and Tom20, and reduced neuronal cell viability. Our results suggest a novel role of myosin IIB in mitochondrial degradation of toxic TDP-25. Therefore, we proposed that regulating myosin IIB activity might be a potential therapeutic target for neurodegenerative diseases associated with TDP-43 pathology. | Jun, Mi-Hee; Jang, Jae-Woo; Jeon, Pureum; Lee, Soo-Kyung; Lee, Sang-Hoon; Choi, Ha-Eun; Lee, You-Kyung; Choi, Haneul; Park, Sang-Won; Kim, Jeongyeon; Jang, Deok-Jin; Lee, Jin-A. | Hannam Univ, Dept Biotechnol & Biol Sci, Daejeon 34054, South Korea; Korea Brain Res Inst, Brain Res Core Facil Ctr, Daegu 41062, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm, Dept Ecol Sci, Sangju Si 37224, South Korea | lee, wj/JNR-4926-2023; Jang, Jaewoo/MCI-7907-2025 | 55206261300; 57219744861; 57208213892; 57219747105; 57219746958; 57193844424; 56651292200; 57219743631; 57211486702; 57219743834; 22234503100; 35337365000 | jangdj@knu.ac.kr;leeja@hnu.kr; | CELL DEATH & DISEASE | CELL DEATH DIS | 2041-4889 | 11 | 11 | SCIE | CELL BIOLOGY | 2020 | 8.469 | 18.7 | 0.43 | 2025-06-25 | 12 | 12 | PROTEIN | Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; HEK293 Cells; Humans; Mitochondria; Mitophagy; Nonmuscle Myosin Type IIB; Peptide Fragments; Ubiquitin-Protein Ligases; blebbistatin; mitofusin 2; molecular motor; myosin IIB; optineurin; parkin; small interfering RNA; TAR DNA binding protein; transcription factor; transcription factor tax1bp; unclassified drug; DNA binding protein; myosin IIB; parkin; peptide fragment; TARDBP protein, human; TDP-25 protein, human; ubiquitin protein ligase; amyotrophic lateral sclerosis; animal experiment; animal model; Article; brain cell; brain tissue; carboxy terminal sequence; cell stress; cell viability; cellular distribution; comparative study; controlled study; DNA fragmentation; HEK293T cell line; human; human cell; mitochondrial membrane potential; mitochondrion; mitophagy; mouse; mRNA expression level; nonhuman; priority journal; protein degradation; quantitative analysis; TDP 43 proteinopathy; amyotrophic lateral sclerosis; genetics; HEK293 cell line; metabolism; pathology | English | 2020 | 2020-11-05 | 10.1038/s41419-020-03165-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus | Iron is an essential element for cellular functions, including those of neuronal cells. However, an imbalance of iron homeostasis, such as iron overload, has been observed in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Iron overload causes neuronal toxicity through mitochondrial fission, dysregulation of Ca2+, ER-stress, and ROS production. Nevertheless, the precise mechanisms between iron-induced oxidative stress and iron toxicity related to mitochondria and endoplasmic reticulum (ER) in vivo are not fully understood. Here, we demonstrate the role of peroxiredoxin 5 (Prx5) in iron overload-induced neurotoxicity using Prx5-deficient mice. Iron concentrations and ROS levels in mice fed a high iron diet were significantly higher in Prx5(-/-) mice than wildtype (WT) mice. Prx5 deficiency also exacerbated ER-stress and ER-mediated mitochondrial fission via Ca2+/calcineurin-mediated dephosphorylation of Drp1 at Serine 637. Moreover, immunoreactive levels of cleaved caspase3 in the CA3 region of the hippocampus were higher in iron-loaded Prx5(-/-) mice than WT mice. Furthermore, treatment with N-acetyl-cysteine, a reactive oxygen species (ROS) scavenger, attenuated iron overload-induced hippocampal damage by inhibiting ROS production, ER-stress, and mitochondrial fission in iron-loaded Prx5(-/-) mice. Therefore, we suggest that iron overload-induced oxidative stress and ER-mediated mitochondrial fission may be essential for understanding iron-mediated neuronal cell death in the hippocampus and that Prx5 may be useful as a novel therapeutic target in the treatment of iron overload-mediated diseases and neurodegenerative diseases. | Lee, Dong Gil; Kam, Min Kyoung; Lee, Sang-Rae; Lee, Hong Jun; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; KRIBB, Natl Primate Res Ctr, Cheongju 28116, South Korea; Chungbuk Natl Univ, Coll Med, Chungbuk, South Korea; Chungbuk Natl Univ Hosp, Dept Radiol, Chungbuk, South Korea; E Biogen Inc, Res Inst, Seoul 07282, South Korea | lee, wj/JNR-4926-2023 | 56824532400; 57195564169; 16026266200; 35215736300; 57210068061 | lee1@knu.ac.kr; | CELL DEATH & DISEASE | CELL DEATH DIS | 2041-4889 | 11 | 3 | SCIE | CELL BIOLOGY | 2020 | 8.469 | 18.7 | 1.17 | 2025-06-25 | 34 | 32 | OXIDATIVE STRESS; FRAGMENTATION; INHIBITION; METABOLISM; CHELATION; DISEASE | Animals; Cell Death; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Female; Hippocampus; Iron Overload; Mice; Mice, Inbred C57BL; Mitochondrial Dynamics; Neurons; Peroxiredoxins; Pregnancy; Signal Transduction; acetylcysteine; activating transcription factor 6; calcineurin; calcium ion; caspase 3; cell protein; drp1 protein; ferritin; GADD34 protein; glucose regulated protein 78; growth arrest and DNA damage inducible protein 153; initiation factor 2alpha; iron; messenger RNA; peroxiredoxin 5; protein Bax; protein bcl 2; protein IRE1; protein IRE1alpha; protein p50; reactive oxygen metabolite; serine; transferrin receptor; unclassified drug; peroxiredoxin; Prdx5 protein, mouse; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; Article; brain mitochondrion; controlled study; degenerative disease; endoplasmic reticulum; endoplasmic reticulum stress; hippocampal CA3 region; hippocampus; immunoreactivity; iron homeostasis; iron overload; male; mouse; nerve cell necrosis; neurotoxicity; nonhuman; oxidative stress; Parkinson disease; priority journal; protein deficiency; protein dephosphorylation; animal; C57BL mouse; cell death; endoplasmic reticulum; female; genetics; hippocampus; iron overload; metabolism; mitochondrial dynamics; nerve cell; pathology; physiology; pregnancy; signal transduction | English | 2020 | 2020-03-23 | 10.1038/s41419-020-2402-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Alteration of Microbiome Profile by D-Allulose in Amelioration of High-Fat-Diet-Induced Obesity in Mice | Recently, there has been a global shift in diet towards an increased intake of energy-dense foods that are high in sugars. D-allulose has received attention as a sugar substitute and has been reported as one of the anti-obesity food components; however, its correlation with the intestinal microbial community is not yet completely understood. Thirty-six C57BL/6J mice were divided in to four dietary groups and fed a normal diet (ND), a high-fat diet (HFD, 20% fat, 1% cholesterol, w/w), and a HFD with 5% erythritol (ERY) and D-allulose (ALL) supplement for 16 weeks. A pair-feeding approach was used so that all groups receiving the high-fat diet would have the same calorie intake. As a result, body weight and body fat mass in the ALL group were significantly decreased toward the level of the normal group with a simultaneous decrease in plasma leptin and resistin. Fecal short-chain fatty acid (SCFA) production analysis revealed that ALL induced elevated total SCFA production compared to the other groups. Also, ALL supplement induced the change in the microbial community that could be responsible for improving the obesity based on 16S rRNA gene sequence analysis, and ALL significantly increased the energy expenditure in Day(6a.m to 6pm). Taken together, our findings suggest that 5% dietary ALL led to an improvement in HFD-induced obesity by altering the microbiome community. | Han, Youngji; Park, Haryung; Choi, Bo-Ra; Ji, Yosep; Kwon, Eun-Young; Choi, Myung-Sook | Kyungpook Natl Univ, Dept Food Sci & Nutr, 1370 San Kyuk Dong, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, 1370 San Kyuk Dong, Daegu 41566, South Korea; Handong Global Univ, Dept Adv Green Energy & Environm, Pohang 37554, South Korea | Park, Grace/U-1673-2018 | 57206914262; 57188966264; 57204739444; 37761601000; 15765422500; 7402093877 | youngji.kor.han@gmail.com;hrpark@microbes.bio;borachoi15@naver.com;jiyosep@gmail.com;eykwon@knu.ac.kr;mschoi@knu.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 2 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 2.63 | 2025-06-25 | 39 | 42 | D-allulose; obesity; metagenomics; microbiome; sugar substitute | GUT MICROBIOTA; BODY-WEIGHT; POTENTIAL ROLE; RARE SUGAR; ENERGY; FRUCTOSE; PREBIOTICS; EPIDEMIC; INSULIN; DISEASE | D-allulose; Metagenomics; Microbiome; Obesity; Sugar substitute | Animals; Diet, High-Fat; Dietary Supplements; Fructose; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Obesity; apolipoprotein B; carbon dioxide; erythritol; high density lipoprotein cholesterol; leptin; psicose; resistin; RNA 16S; short chain fatty acid; triacylglycerol; fructose; psicose; animal experiment; animal tissue; Article; bacterial microbiome; bacterium; body fat; body weight; caloric intake; controlled study; Coprococcus; diet supplementation; diet-induced obesity; DNA extraction; energy expenditure; enzyme activity; Erysipelotrichaceae; gas chromatography; gene sequence; genetic analysis; Lactobacillus; lipid diet; lipid fingerprinting; male; metagenomics; microbial community; microbiome; microflora; mouse; nonhuman; oxygen consumption; Turicibacter; adverse event; animal; C57BL mouse; dietary supplement; drug effect; intestine flora; obesity | English | 2020 | 2020-02 | 10.3390/nu12020352 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-Diabetic Effects of Allulose in Diet-Induced Obese Mice via Regulation of mRNA Expression and Alteration of the Microbiome Composition | Allulose has been reported to serve as an anti-obesity and anti-diabetic food component; however, its molecular mechanism is not yet completely understood. This study aims to elucidate the mechanisms of action for allulose in obesity-induced type 2 diabetes mellitus (T2DM), by analyzing the transcriptional and microbial populations of diet-induced obese mice. Thirty-six C57BL/6J mice were divided into four groups, fed with a normal diet (ND), a high-fat diet (HFD), a HFD supplemented with 5% erythritol, or a HFD supplemented with 5% allulose for 16 weeks, in a pair-fed manner. The allulose supplement reduced obesity and comorbidities, including inflammation and hepatic steatosis, and changed the microbial community in HFD-induced obese mice. Allulose attenuated obesity-mediated inflammation, by downregulating mRNA levels of inflammatory response components in the liver, leads to decreased plasma pro-inflammatory marker levels. Allulose suppressed glucose and lipid metabolism-regulating enzyme activities, ameliorating hepatic steatosis and improving dyslipidemia. Allulose improved fasting blood glucose (FBG), plasma glucose, homeostatic model assessment of insulin resistance (HOMA-IR), and the area under the curve (AUC) for the intraperitoneal glucose tolerance test (IPGTT), as well as hepatic lipid levels. Our findings suggested that allulose reduced HFD-induced obesity and improved T2DM by altering mRNA expression and the microbiome community. | Han, Youngji; Kwon, Eun-Young; Choi, Myung-Sook | Kyungpook Natl Univ, Dept Food Sci & Nutr, 1370 San Kyuk Dong Puk Ku, Daegu 702701, South Korea; Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, 1370 San Kyuk Dong Puk Ku, Daegu 702701, South Korea | 57206914262; 7402093877; 15765422500 | youngji.kor.han@gmail.com;eykwon@knu.ac.kr;mschoi@knu.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 7 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 1.19 | 2025-06-25 | 26 | 23 | anti-diabetes; anti-obesity; functional sweetener; rare sugar | INSULIN-RESISTANCE; METABOLIC SYNDROME; SUGAR SUBSTITUTES; PATHOPHYSIOLOGY; INFLAMMATION; CONSUMPTION; BEVERAGES; HEALTH; RISK | Anti-diabetes; Anti-obesity; Functional sweetener; Rare sugar | Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Supplements; Fructose; Gastrointestinal Microbiome; Glucose; Hypoglycemic Agents; Inflammation; Inflammation Mediators; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Obesity; Phytotherapy; RNA, Messenger; apolipoprotein A1; apolipoprotein B; aspartate aminotransferase; fatty acid synthase; gastric inhibitory polypeptide; glucagon like peptide 1; glucose; high density lipoprotein cholesterol; immunoglobulin enhancer binding protein; insulin; interleukin 10; interleukin 6; low density lipoprotein cholesterol; messenger RNA; monocyte chemotactic protein 1; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor gamma; resistin; RNA 16S; saturated fatty acid; short chain fatty acid; triacylglycerol; antidiabetic agent; autacoid; fructose; glucose; messenger RNA; psicose; animal experiment; animal model; animal tissue; Article; blood sampling; body composition; body weight gain; controlled study; diet supplementation; diet-induced obesity; DNA extraction; gas chromatography; glucose blood level; glucose metabolism; glycemic index; histology; histopathology; homeostasis model assessment; immunohistochemistry; insulin blood level; insulin release; insulin response; intestine flora; lipolysis; male; microbial community; molecular mechanics; mouse; mRNA expression level; nonhuman; oral glucose tolerance test; phenotype; RNA sequence; signal transduction; adverse event; animal; C57BL mouse; dietary supplement; genetics; inflammation; insulin resistance; lipid diet; lipid metabolism; liver; metabolism; microbiology; non insulin dependent diabetes mellitus; obesity; phytotherapy | English | 2020 | 2020-07 | 10.3390/nu12072113 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Anti-Diabetic Obesity Effects ofWasabia JaponicaMatsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice | The present study examined the effects of Wasabi leaf (WL) on 45% Kcal high-fat diet (HFD)-fed mild diabetic obese mice. In particular, the hepatoprotective (i.e., liver weight, histopathology of liver, serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase) effects of 12 weeks of continuous oral administration of 250 mg/kg metformin, and 200, 100, or 50 mg/kg WL were investigated. In addition, the hypolipidemic (i.e., serum triglyceride, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein levels), hypoglycemic (i.e., glycated hemoglobin, blood glucose and insulin levels, pancreatic weight, and immunohistochemical-histopathological analysis of the pancreas), and anti-obesity effects (i.e., body weight, mean food consumption, total and abdominal body fat mass, periovarian fat weight, and histopathology of the periovarian and abdominal wall adipocytes) were monitored. The liver and general antioxidant defense systems were also assessed by lipid metabolism-related gene expression. All diabetes manifestations and related complications, including obesity and non-alcoholic fatty liver disease (NAFLD), were dose-dependently reduced after 84 days of oral treatment with metformin or each of the three dosages of WL. In particular, 50 mg/kg WL showed effective suppression effects against HFD-induced diabetes and related complications of obesity, NAFLD, and hyperlipidemia, comparable to the effects of metformin. | Choi, Beom-Rak; Kim, Hyun-Jee; Lee, Young-Joon; Ku, Sae-Kwang | Nutracore Co Ltd, Res Inst, Gwanggyo SK Viewlake A-3206,Beobjo Ro 25, Suwon 16514, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Anesthesiol & Pain Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Deagu Haany Univ, Dept Prevent Med, Coll Korean Med, 1 Haanydaero, Gyongsan 38610, Gyeongsangbuk D, South Korea; Daegu Haany Univ, Dept Anat & Histol, Coll Korean Med, 1 Haanydaero, Gyongsan 38610, Gyeongsangbuk D, South Korea | Kim, Heebal/A-8889-2016 | 56595969400; 57208674365; 57189311884; 7006331005 | brchoi@nutracore.co.kr;hj_kim@knu.ac.kr;gksxntk@dhu.ac.kr;gucci200@hanmail.net; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 9 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 0.8 | 2025-06-25 | 16 | 15 | wasabi leaf; folium; Wasabia japonica(miq; ) matsum; obesity; diabetes; hepatic glucose-regulating enzyme; lipid metabolism-related gene expression | ACTIVATED PROTEIN-KINASE; GREEN TEA; 6-METHYLSULFINYLHEXYL ISOTHIOCYANATE; GLUCOSE-UTILIZATION; OXIDATIVE STRESS; NATURAL-PRODUCT; AMPK ACTIVATION; INSULIN; ADIPONECTIN; GLUCOKINASE | Diabetes; Hepatic glucose-regulating enzyme; Lipid metabolism-related gene expression; Obesity; Wasabi leaf/folium; Wasabia japonica (miq.) matsum | Animals; Anti-Obesity Agents; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Female; Mice; Mice, Obese; Obesity; Plant Extracts; Wasabia; cholesterol; glucagon; hemoglobin A1c; high density lipoprotein; immunoreactive insulin; low density lipoprotein cholesterol; metformin; plant extract; triacylglycerol; unclassified drug; Wasabia japonica extract; zymogen granule; antiobesity agent; plant extract; abdominal wall; adipocyte; adipose tissue; animal cell; animal experiment; animal model; animal tissue; antidiabetic activity; antiobesity activity; Article; body fat; body weight change; cholesterol blood level; controlled study; diabetic obesity; enzyme activity; exocrine pancreas; fat pad; fatty liver; female; food intake; gene expression; glucose blood level; histopathology; hyperlipidemia; hypolipemia; immunohistochemistry; insulin blood level; lipid blood level; lipid diet; lipid liver level; lipid metabolism; lipid peroxidation; liver cell; liver disease; liver protection; liver weight; mouse; nonalcoholic fatty liver; nonhuman; pancreas islet; plant leaf; wasabi; animal; complication; disease model; Eutrema; experimental diabetes mellitus; lipid diet; mouse mutant; obesity | English | 2020 | 2020-09 | 10.3390/nu12092837 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-Fatigue Effect ofPrunus MumeVinegar in High-Intensity Exercised Rats | Nowadays, new types of vinegar have been developed using various raw materials and biotechnological processes. The fruit ofPrunus mumehas been extensively distributed in East Asia and used as a folk medication for fatigue. In this study, thePrunus mumevinegar (PV) was produced by a two-step fermentation and was evaluated for its anti-fatigue activity by C2C12 myoblasts and high-intensity exercised rats. The administration of PV significantly improved running endurance and glycogen accumulation in the liver and muscle of PV supplemented rats compared to sedentary and exercised control groups. In addition, PV supplementation elicited lower fatigue-related serum biomarkers, for instance, ammonia, inorganic phosphate, and lactate. PV administered rats exhibited higher lactate dehydrogenase activity and glutathione peroxidase activity, and lower creatine kinase activity and malondialdehyde levels. Furthermore, phenolic compounds in PV were identified using HPLC analysis. The phenolic acids analyzed in PV were protocatechuic acid, syringic acid, chlorogenic acid, and its derivates. These results indicate that the administration of PV with antioxidative property contributes to the improvement of fatigue recovery in exhausted rats. The findings of this study suggest that the PV containing various bioactive constituents can be used as a functional material against fatigue caused by high-intensity exercise. | Kim, Jeong-Ho; Cho, Hyun-Dong; Won, Yeong-Seon; Hong, Seong-Min; Moon, Kwang-Deog; Seo, Kwon-Il | Kyungpook Natl Univ, Dept Food Sci & Technol, Daegu 41566, South Korea; Dong A Univ, Inst Agr Life Sci, Busan 49315, South Korea; Dong A Univ, Dept Food Biotechnol, Busan 49315, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea | Cho, Hyun-Dong/HLW-0763-2023; Kim, Jeong-Ho/A-7641-2018 | 57194659775; 55383853000; 59148009100; 57194647985; 55999192900; 59836699000 | kimjeoho90@gmail.com;chd0811@hanmail.net;wonys@dau.ac.kr;hongsm0517@gmail.com;kdmoon@knu.ac.kr;kseo@dau.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 5 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 1.99 | 2025-06-25 | 33 | 36 | prunus mume; vinegar; anti-fatigue effect; high-intensity exercise; phenolic acid | ACETIC-ACID; SKELETAL-MUSCLE; ANTIOXIDANT ACTIVITY; GLYCOGEN REPLETION; VINEGAR; POLYPHENOLS; ACETATE | Anti-fatigue effect; High-intensity exercise; Phenolic acid; Prunus mume; Vinegar | Acetic Acid; Amino Acids; Animals; Biomarkers; Cell Proliferation; Chemical Phenomena; Chromatography, High Pressure Liquid; Dietary Supplements; Fatigue; Fermentation; Glycogen; Hydroxybenzoates; Male; Malondialdehyde; Mice; Myoblasts; Phenols; Physical Conditioning, Animal; Prunus; Rats; antioxidant; chlorogenic acid; cichoric acid; creatine kinase; flavonoid; gallic acid; glutathione; glutathione peroxidase; glycogen; lactate dehydrogenase; lactic acid; malonaldehyde; neochlorogenic acid; polyvinylidene fluoride; protocatechuic acid; sulforhodamine B; syringic acid; vinegar; acetic acid; amino acid; biological marker; glycogen; hydroxybenzoic acid derivative; phenol derivative; phenolic acid; acidity; animal cell; animal experiment; antioxidant activity; Article; biochemical analysis; cell viability; chemical composition; controlled study; cytotoxicity; diet supplementation; DPPH radical scavenging assay; endurance training; enzyme activity; exercise; experimental design; fatigue; gastrocnemius muscle; glycogen analysis; high performance liquid chromatography; hypothalamus; lipid composition; lipid storage; male; nonhuman; protein phosphorylation; Prunus; Prunus Mume; rat; resistance training; Saccharomyces cerevisiae; treadmill exercise; animal; animal experiment; cell proliferation; chemical phenomena; chemistry; dietary supplement; drug effect; fatigue; fermentation; metabolism; mouse; myoblast; Prunus | English | 2020 | 2020-05 | 10.3390/nu12051205 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cornus officinalis Ethanolic Extract with Potential Anti-Allergic, Anti-Inflammatory, and Antioxidant Activities | Atopic dermatitis (AD) is an allergic and chronic inflammatory skin disease. The present study investigates the anti-allergic, antioxidant, and anti-inflammatory activities of the ethanolic extract of Cornus officinalis (COFE) for possible applications in the treatment of AD. COFE inhibits the release of beta-hexosaminidase from RBL-2H3 cells sensitized with the dinitrophenyl-immunoglobulin E (IgE-DNP) antibody after stimulation with dinitrophenyl-human serum albumin (DNP-HSA) in a concentration-dependent manner (IC50 = 0.178 mg/mL). Antioxidant activity determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power assay, and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity, result in EC50 values of 1.82, 10.76, and 0.6 mg/mL, respectively. Moreover, the extract significantly inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and the mRNA expression of iNOS and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) through attenuation of NF-kappa B activation in RAW 264.7 cells. COFE significantly inhibits TNF-alpha-induced apoptosis in HaCaT cells without cytotoxic effects (p < 0.05). Furthermore, 2-furancarboxaldehyde and loganin are identified by gas chromatography/mass spectrometry (GC-MS) and liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis, respectively, as the major compounds. Molecular docking analysis shows that loganin, cornuside, and naringenin 7-O-beta-D-glucoside could potentially disrupt the binding of IgE to human high-affinity IgE receptors (FceRI). Our results suggest that COFE might possess potential inhibitory effects on allergic responses, oxidative stress, and inflammatory responses. | Quah, Yixian; Lee, Seung-Jin; Lee, Eon-Bee; Birhanu, Biruk Tesfaye; Ali, Md Sekendar; Abbas, Muhammad Aleem; Boby, Naila; Im, Zi-Eum; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Pharmacol, Daegu 41944, South Korea; Int Islamic Univ Chittagong, Dept Pharm, Kumira 4318, Chittagong, Bangladesh; Forest Resources Dev Inst Gyeongsangbuk Do, Andong Si 36605, Gyeongsangbuk D, South Korea | Boby, Naila/GRE-8096-2022; Abbas, Muhammad Aleem/GLT-8362-2022; Birhanu, Biruk/F-1622-2017; Yixian, Quah/ABE-7629-2021; Park, Seung-Chun/AAV-3388-2021; Lee, Jun Young/CAI-2335-2022; Lee, Jung Bok/HHZ-3200-2022 | 55886933200; 58689440900; 57216526135; 56996190000; 57219661221; 57216531374; 57197787296; 57205463137; 7501832396 | im.yixianquah@gmail.com;dvmleesj@naver.com;eonbee@gmail.com;btbtes@gmail.com;alipharm2000@gmail.com;syedaleemabbas77@gmail.com;nailaboby1584@gmail.com;zium78@korea.kr;parksch@knu.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 11 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 3.02 | 2025-06-25 | 57 | 56 | anti-inflammatory activity; antioxidant activity; atopic dermatitis; Cornus officinalis; molecular docking; human high-affinity IgE receptors | INDUCED INFLAMMATORY MEDIATORS; ALLERGIC RESPONSE; ATOPIC-DERMATITIS; FRUIT EXTRACT; MORRONISIDE; ACTIVATION; LOGANIN | Anti-inflammatory activity; Antioxidant activity; Atopic dermatitis; Cornus officinalis; Human high-affinity IgE receptors; Molecular docking | Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antioxidants; Chromatography, Liquid; Cornus; Cytokines; Ethanol; Humans; Lipopolysaccharides; Mice; Molecular Docking Simulation; Nitric Oxide; Oxidative Stress; Plant Extracts; RAW 264.7 Cells; Tandem Mass Spectrometry; 2 furancarboxaldehyde; 2,4 dinitrophenol; alcohol; aldehyde; ascorbic acid; beta n acetylhexosaminidase; Cornus officinalis extract; cornuside; flavonoid; human serum albumin; immunoglobulin E; immunoglobulin E receptor; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; lipopolysaccharide; loganin; messenger RNA; naringenin 7 o beta dextro glucoside; nitric oxide; tumor necrosis factor; unclassified drug; alcohol; antiallergic agent; antiinflammatory agent; antioxidant; cytokine; nitric oxide; plant extract; ABTS radical scavenging assay; animal cell; animal experiment; antiallergic activity; antiinflammatory activity; antioxidant activity; apoptosis; Article; atopic dermatitis; controlled study; Cornus officinalis; degranulation; DPPH radical scavenging assay; drug efficacy; drug potency; EC50; female; ferric reducing antioxidant power assay; gene expression; HaCat cell line; human; human cell; IC50; inflammation; liquid chromatography-mass spectrometry; mass fragmentography; molecular docking; nonhuman; oxidative stress; rat; RAW 264.7 cell line; RBL-2H3 cell line; animal; biosynthesis; Cornus; drug effect; liquid chromatography; metabolism; mouse; tandem mass spectrometry | English | 2020 | 2020-11 | 10.3390/nu12113317 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dietary Protein to Carbohydrate Ratio and Incidence of Metabolic Syndrome in Korean Adults Based on a Long-Term Prospective Community-Based Cohort | Interest in high protein diets has recently been increasing for reduction of weight or management of cardiometabolic risks. However, studies on high protein, low carbohydrate diet in Asians are limited. This study aimed to estimate whether the dietary ratio of protein (%) to carbohydrate (%) from total energy intake (p/c ratio) is associated with the risk of metabolic syndrome (MS) and its components in Korean adults using a long-term prospective cohort. A total of 6335 participants from the Korean Genome and Epidemiology Study, aged between 40 and 69 years, with no previous diagnosis of MS, cardiovascular diseases, or cancer at baseline (2001-2002) were followed until 2013. Dietary intake was measured using a validated semiquantitative food-frequency questionnaire. MS components were measured at baseline and every 2 years. During a mean of 7.7 years of follow up, 1198 (36.1%) men and 1169 (38.8%) women developed MS. The multivariate adjusted hazard ratio (HR) of incident MS was 1.43 (95% confidence interval, 1.09-1.89) for the highest compared lowest quintile of p/c ratio in men. When evaluating each component of MS, higher dietary p/c ratio was associated with an increased risk of high triglyceride and fasting glucose in men (HR for fifth vs. first quintile, 1.39 and 1.41 in Model 3, respectively). However, we observed no associations with incident MS and its components and dietary p/c ratio in women. In conclusion, we found that high dietary p/c ratio was associated with an increased risk of MS and its components (i.e., increased triglycerides and fasting glucose) in men. Our study suggested that even if the absolute amount of protein intake is not large, an increased p/c ratio may increase the risk of metabolic diseases. | Paik, Jean Kyung; Park, Mira; Shin, Ji Eun; Jang, Suk-Yong; Shin, Ji-Yeon | Eulji Univ, Dept Food & Nutr, Seongnam 13135, South Korea; Eulji Univ, Sch Med, Dept Prevent Med, Deajeon 34824, South Korea; Woosuk Univ, Dept Liberal Arts, Jeollabuk Do 55338, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 47944, South Korea | 16069145700; 36121282700; 57204168800; 56539174800; 55567961600 | jkpaik@eulji.ac.kr;mira@eulji.ac.kr;je_shin@woosuk.ac.kr;sukyong@eulji.ac.kr;nunmulgyupda@hanmail.net; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 11 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 0.32 | 2025-06-25 | 9 | 9 | protein; carbohydrate; ratio; metabolic syndrome | INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID-METABOLISM; CALORIC-INTAKE; RISK; DISEASE; WEIGHT; HEALTH; ENERGY; SEX | Carbohydrate; Metabolic syndrome; Protein; Ratio | Adult; Aged; Blood Glucose; Cardiometabolic Risk Factors; Diet; Diet Surveys; Dietary Carbohydrates; Dietary Proteins; Energy Intake; Fasting; Female; Humans; Incidence; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Proportional Hazards Models; Prospective Studies; Republic of Korea; Sex Factors; Triglycerides; carbohydrate; glucose; high density lipoprotein cholesterol; triacylglycerol; triacylglycerol; adult; aged; Article; body mass; caloric intake; cohort analysis; controlled study; diastolic blood pressure; female; follow up; food frequency questionnaire; glucose blood level; high density lipoprotein cholesterol level; human; incidence; Korean (people); macronutrient; major clinical study; male; median survival time; metabolic syndrome X; nutritional assessment; prospective study; protein intake; social status; systolic blood pressure; triacylglycerol blood level; waist circumference; adverse event; blood; carbohydrate diet; diet; diet restriction; longitudinal study; metabolic syndrome X; middle aged; proportional hazards model; protein intake; sex factor; South Korea | English | 2020 | 2020-11 | 10.3390/nu12113274 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of Korean Red Ginseng on Cholesterol Metabolites in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial | Korean red ginseng (KRG) is known to exert beneficial effects on cardiovascular health. Meanwhile, reduced estrogen at menopause has been shown to have various adverse impacts on cardiovascular risk factors, including blood lipids. The aim of this pilot study was to investigate the effect of KRG on cholesterol metabolites, which are surrogate markers of cholesterol absorption and biosynthesis, in postmenopausal women with hypercholesterolemia. The present study is an exploratory study which used data from a 4-week, double-blinded, placebo-controlled clinical pilot study in 68 postmenopausal women with hypercholesterolemia. Patients received KRG (2 g) or placebo (2 g) once daily. The primary endpoints were changes in the levels of nine sterols. Serum sterols were analyzed using liquid chromatography-mass spectrometry (LC-MS)/MS analysis. Among the sterols, reduction in cholesterol level were significantly larger in the KRG group than in the placebo group (the changes: -148.3 +/- 261.1 nmol/mL in the ginseng group vs. -23.0 +/- 220.5 nmol/mL in the placebo group, p = 0.039). Additionally, changes in 7-hydroxycholesterol (7-OHC) were significantly larger in the KRG group than in the placebo group (the changes: -0.05 +/- 0.09 nmol/mL in the ginseng group vs. -0.002 +/- 0.1 nmol/mL in the placebo group, p = 0.047). Oxysterols, cholesterol derivates, have been known to play a role in chronic inflammation diseases such as cardiovascular diseases. KRG improves sterol metabolism by decreasing cholesterol and 7-OHC levels in postmenopausal women with hypercholesterolemia. | Kwon, Yu-Jin; Jang, Su-Nyeong; Liu, Kwang-Hyeon; Jung, Dong-Hyuk | Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, Yongin 16995, South Korea; Kyungpook Natl Univ, Coll Pharm, Plus KNU Multiom Based Creat Drug Res Team BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea | ; Kwon, Yu-Jin/ACB-8082-2022 | 57188592099; 57211630666; 55768214700; 35738919100 | digda3@yuhs.ac;wts1424@naver.com;dstlkh@gmail.com;balsan2@yuhs.ac; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 11 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 0.88 | 2025-06-25 | 18 | 20 | Korean red ginseng; cholesterol metabolism; sterols; menopause; women | ACTIVATES ESTROGEN-RECEPTOR; CARDIOVASCULAR-DISEASE; LIPID-ACCUMULATION; AMPK ACTIVATION; PANAX-GINSENG; RISK-FACTORS; DOUBLE-BLIND; OXYSTEROLS; GINSENOSIDES; HOMEOSTASIS | Cholesterol metabolism; Korean red ginseng; Menopause; Sterols; Women | Cholesterol; Female; Humans; Hypercholesterolemia; Metabolome; Middle Aged; Panax; Pilot Projects; Placebos; Postmenopause; campesterol; cholesterol; ginseng extract; korean red ginseng; oxysterol; phytosterol; placebo; sitosterol; starch; unclassified drug; adult; Article; biosynthesis; body mass; cardiovascular disease; cholesterol blood level; cholesterol level; cholesterol metabolism; clinical trial; controlled study; diastolic blood pressure; double blind procedure; drug effect; exploratory research; female; ginseng; heart rate; human; human tissue; hypercholesterolemia; insomnia; liquid chromatography-mass spectrometry; major clinical study; metabolite; pilot study; postmenopause; randomized controlled trial; systolic blood pressure; tablet; waist circumference; chemistry; hypercholesterolemia; metabolism; metabolome; middle aged; Panax; postmenopause | English | 2020 | 2020-11 | 10.3390/nu12113423 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of Branched-Chain Amino Acid (BCAA) Supplementation on the Progression of Advanced Liver Disease: A Korean Nationwide, Multicenter, Prospective, Observational, Cohort Study | Background and Aims: Clinical evidence for the benefits of branched-chain amino acids (BCAAs) is lacking in advanced liver disease. We evaluated the potential benefits of long-term oral BCAA supplementation in patients with advanced liver disease. Methods: Liver cirrhosis patients with Child-Pugh (CP) scores from 8 to 10 were prospectively recruited from 13 medical centers. Patients supplemented with 12.45 g of daily BCAA granules over 6 months, and patients consuming a regular diet were assigned to the BCAA and control groups, respectively. The effects of BCAA supplementation were evaluated using the model for end-stage liver disease (MELD) score, CP score, serum albumin, serum bilirubin, incidence of cirrhosis-related events, and event-free survival for 24 months. Results: A total of 124 patients was analyzed: 63 in the BCAA group and 61 in the control group. The MELD score (p= 0.009) and CP score (p= 0.011) significantly improved in the BCAA group compared to the control group over time. However, the levels of serum albumin and bilirubin in the BCAA group did not improve during the study period. The cumulative event-free survival was significantly improved in the BCAA group compared to the control group (HR = 0.389, 95% CI = 0.221-0.684,p< 0.001). Conclusion: Long-term supplementation with oral BCAAs can potentially improve liver function and reduce major complications of cirrhosis in patients with advanced liver disease. | Park, Jung Gil; Tak, Won Young; Park, Soo Young; Kweon, Young Oh; Chung, Woo Jin; Jang, Byoung Kuk; Bae, Si Hyun; Lee, Heon Ju; Jang, Jae Young; Suk, Ki Tae; Oh, Myung Jin; Heo, Jeong; Woo, Hyun Young; Jang, Se Young; Lee, Yu Rim; Lee, June Sung; Kim, Do Young; Kim, Seok Hyun; Suh, Jeong Ill; Kim, In Hee; Kang, Min Kyu; Lee, Won Kee | Yeungnam Univ, Coll Med, Dept Internal Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu 42601, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 06591, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Seoul 04401, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chunchon 24252, South Korea; CHA Univ, CHA Gumi Med Ctr, Dept Internal Med, Sch Med, Gumi 39295, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan 49241, South Korea; Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Internal Med, Goyang 10380, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul 03722, South Korea; Choungnam Natl Univ, Sch Med, Dept Internal Med, Daejeon 61469, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju 39067, South Korea; Chonbuk Natl Univ, Sch Med, Dept Internal Med, Chungju 54907, South Korea; Kyungpook Natl Univ, Med Res Collabrat Ctr KNUH, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea | ; Kim, Dong/F-4608-2014; Heo, Jeong/MHQ-1390-2025; Park, Jung/AAK-5167-2020; Lee, Hyo-Suk/J-5618-2012; Kang, Min/U-8050-2018; Kang, Min Kyu/U-8050-2018 | 57216816399; 7004074582; 57191674344; 7004694832; 55741230500; 58849853600; 57578310300; 55085510500; 57221679776; 7005114563; 59099937700; 8422238800; 12787138800; 57202881977; 57194094753; 8429951900; 56119929100; 57049759100; 7201515001; 7404143744; 59142854300; 22953484700 | gsnrs@naver.com;wytak@knu.ac.kr;psyoung0419@gmail.com;yokweon@knu.ac.kr;chung50@dsmc.or.kr;jangha106@dsmc.or.kr;baesh@catholic.ac.kr;hjlee@med.yu.ac.kr;jyjang@hosp.sch.ac.kr;ktsuk@hallym.ac.kr;zenus1@hanmail.net;jheo@pusan.ac.kr;who54@hanmail.net;magnolia1103@naver.com;deblue00@naver.com;jsleemd@paik.ac.kr;dyk1025@yuhs.ac;midoctor@cnu.ac.kr;sujungil@dongguk.ac.kr;ihkimmd@chonbuk.ac.kr;kmggood111@naver.com;wonlee@knu.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 5 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 2.23 | 2025-06-25 | 38 | 44 | amino acids; branched-chain; liver cirrhosis; prognosis; ascites; hepatic encephalopathy | EVENT-FREE SURVIVAL; HEPATOCELLULAR-CARCINOMA; SARCOPENIA; CIRRHOSIS; NUTRITION; GRANULES | Aged; Amino Acids, Branched-Chain; Bilirubin; Dietary Supplements; Disease Progression; Female; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Progression-Free Survival; Prospective Studies; Republic of Korea; Serum Albumin; Severity of Illness Index; Time Factors; Treatment Outcome; alanine aminotransferase; albumin; aspartate aminotransferase; bilirubin; branched chain amino acid; creatinine; DNA; entecavir; gamma glutamyltransferase; hepatitis B surface antigen; isoleucine; leucine; RNA; tenofovir; valine; warfarin; bilirubin; branched chain amino acid; serum albumin; adult; alcohol consumption; Article; ascites; bacterial peritonitis; Child Pugh score; clinical assessment; cohort analysis; controlled study; diet supplementation; event free survival; female; follow up; hepatic encephalopathy; hepatitis B; hepatitis C; hepatorenal syndrome; human; intervention study; liver cell carcinoma; liver cirrhosis; liver disease; liver function test; major clinical study; male; middle aged; Model For End Stage Liver Disease Score; mortality; multicenter study; observational study; patient compliance; patient counseling; platelet count; prospective study; prothrombin time; protocol compliance; retroperitoneal hemorrhage; urea nitrogen blood level; virus load; aged; blood; clinical trial; dietary supplement; disease exacerbation; liver; liver cirrhosis; pathophysiology; prospective study; severity of illness index; South Korea; time factor; treatment outcome | English | 2020 | 2020-05 | 10.3390/nu12051429 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice | Ganoderma lucidum is used widely in oriental medicine to treat obesity and metabolic diseases. Bioactive substances extracted from G. lucidum have been shown to ameliorate dyslipidemia, insulin resistance, and type 2 diabetes in mice via multiple 5 ' AMP-activated protein kinase (AMPK)-mediated mechanisms; however, further studies are required to elucidate the anti-obesity effects of G. lucidum in vivo. In this study, we demonstrated that 3% G. lucidum extract powder (GEP) can be used to prevent obesity and insulin resistance in a mouse model. C57BL/6 mice were provided with a normal diet (ND) or a high-fat diet (HFD) supplemented with 1, 3, or 5% GEP for 12 weeks and the effect of GEP on body weight, liver, adipose tissue, adipokines, insulin and glucose tolerance (ITT and GTT), glucose uptake, glucose-metabolism related proteins, and lipogenesis related genes was examined. GEP administration was found to reduce weight gain in the liver and fat tissues of the mice. In addition, serum parameters were significantly lower in the 3% and 5% GEP mice groups than in those fed a HFD alone, whereas adiponectin levels were significantly higher. We also observed that GEP improved glucose metabolism, reduced lipid accumulation in the liver, and reduced adipocyte size. These effects may have been mediated by enhanced AMPK activation, which attenuated the transcription and translation of lipogenic genes such as fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1), and sterol regulatory element-binding protein-1c (SREBP1c). Moreover, AMP-activated protein kinase (AMPK) activation increased acetyl-CoA carboxylase (ACC), insulin receptor (IR), IR substrate 1 (IRS1), and Akt protein expression and activation, as well as glucose transporter type 1/4 (GLUT1/4) protein production, thereby improving insulin sensitivity and glucose metabolism. Together, these findings demonstrate that G. lucidum may effectively prevent obesity and suppress obesity-induced insulin resistance via AMPK activation. | Lee, Hyeon A.; Cho, Jae-Han; Afinanisa, Qonita; An, Gi-Hong; Han, Jae-Gu; Kang, Hyo Jeung; Choi, Seong Ho; Seong, Hyun-A | Chungbuk Natl Univ, Sch Biol Sci, Dept Biochem, Cheongju 28644, South Korea; RDA Eumseong, Natl Inst Hort & Herbal Sci, Mushroom Res Div, Chungbuk 27709, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Chungbuk Natl Univ, Dept Anim Sci, Cheongju 28644, South Korea | 57219652973; 57188706763; 57200559238; 57224361331; 25652633500; 8979751700; 57118481500; 7005738442 | hyeona@chungbuk.ac.kr;limitcho@korea.kr;qonita@chungbuk.ac.kr;agiho@korea.kr;hkang72@knu.ac.kr;seongho@cbnu.ac.kr;haseung@cbnu.ac.kr; | NUTRIENTS | NUTRIENTS | 2072-6643 | 12 | 11 | SCIE | NUTRITION & DIETETICS | 2020 | 5.719 | 18.8 | 1.67 | 2025-06-25 | 39 | 41 | anti-obesity; Ganoderma; lipogenesis; AMPK; insulin resistance | METABOLISM; MECHANISMS; KINASE; ALPHA; ACID | AMPK; Anti-obesity; Ganoderma; Insulin resistance; Lipogenesis | Acetyl-CoA Carboxylase; Adiponectin; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Enzyme Activation; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leptin; Lipids; Lipogenesis; Liver; Mice, Inbred C57BL; Mice, Obese; Obesity; Reishi; RNA, Messenger; Signal Transduction; acetyl coenzyme A carboxylase; acyl coenzyme A desaturase 1; adipocytokine; adiponectin; fatty acid; fatty acid synthase; Ganoderma lucidum extract; glucose; glucose transporter 1; glucose transporter 4; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase kinase; insulin; insulin receptor; insulin receptor substrate 1; leptin; low density lipoprotein cholesterol; protein kinase B; RNA 18S; sterol regulatory element binding protein 1c; triacylglycerol; acetyl coenzyme A carboxylase; adiponectin; glucose; hydroxymethylglutaryl coenzyme A reductase kinase; insulin; leptin; lipid; messenger RNA; adipocyte; adipose tissue; animal experiment; animal model; animal tissue; Article; body weight; cholesterol blood level; controlled study; diet-induced obesity; enzyme activation; gene expression; glucose metabolism; glucose tolerance; glucose transport; histopathology; insulin resistance; insulin sensitivity; insulin tolerance test; lipid storage; lipogenesis; liver; liver cell; male; mouse; nonhuman; polyacrylamide gel electrophoresis; protein expression; real time polymerase chain reaction; real time reverse transcription polymerase chain reaction; science; triacylglycerol blood level; upregulation; white adipose tissue; animal; blood; C57BL mouse; chemistry; Ganoderma lucidum; gene expression regulation; genetics; glucose tolerance test; insulin resistance; lipid diet; metabolism; mouse mutant; obesity; pathology; signal transduction | English | 2020 | 2020-11 | 10.3390/nu12113338 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Letter | Letter to the Editor: Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study | Lee, Yu-Mi; Lee, Duk-Hee | Kyungpook Natl Univ, Dept Prevent Med, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea | 57075191600; 57211851121 | lee_dh@knu.ac.kr; | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | J CLIN ENDOCR METAB | 0021-972X | 1945-7197 | 105 | 2 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.958 | 18.8 | 0 | 2025-06-25 | 0 | 0 | ADIPOSE-TISSUE; LIPOLYSIS | Cohort Studies; Dementia; Humans; Obesity; insulin; organic compound; adipocyte; adipose tissue; adverse outcome; body weight loss; brain level; cardiovascular risk; dementia; disease association; fat mass; high risk patient; human; incidental finding; insulin resistance; Letter; lipolysis; low risk patient; metabolically healthy obese; metabolism; obesity; persistent organic pollutant; population research; priority journal; risk assessment; risk factor; South Korean; cohort analysis | English | 2020 | 2020-02 | 10.1210/clinem/dgz081 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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