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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ The Influence of Australian Bushfire on the Upper Tropospheric CO and Hydrocarbon Distribution in the South Pacific ⓘ To determine the long-term effect of Australian bushfires on the upper tropospheric composition in the South Pacific, we investigated the variation in CO and hydrocarbon species in the South Pacific according to the extent of Australian bushfires (2004-2020). We conducted analyses using satellite data on hydrocarbon and CO from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS), and on fire (fire count, burned area, and fire radiative power) from the Moderate Resolution Imaging Spectroradiometer (MODIS). Additionally, we compared the effects of bushfires between Northern and Southeastern Australia (NAᵤₛ and SEAᵤₛ, respectively). Our analyses show that Australian bushfires in austral spring (September to November) result in the largest increase in CO and hydrocarbon species in the South Pacific and even in the west of South America, indicating the trans-Pacific transport of smoke plumes. In addition to HCN (a well-known wildfire indicator), CO and other hydrocarbon species (C2H2, C2H6, CH3OH, HCOOH) are also considerably increased by Australian bushfires. A unique finding in this study is that the hydrocarbon increase in the South Pacific mostly relates to the bushfires in NAᵤₛ, implying that we need to be more vigilant of bushfires in NAᵤₛ, although the severe Australian bushfire in 2019-2020 occurred in SEAᵤₛ. Due to the surface conditions in springtime, bushfires on grassland in NAᵤₛ during this time account for most Australian bushfires. All results show that satellite data enables us to assess the long-term effect of bushfires on the air composition over remote areas not having surface monitoring platforms. ⓘ Lee, Donghee; Kim, Jin-Soo; Walker, Kaley; Sheese, Patrick; Park, Sang Seo; Choi, Taejin; Park, Minju; Song, Hwan-Jin; Koo, Ja-Ho ⓘ Yonsei Univ, Dept Atmospher Sci, Seoul 03722, South Korea; City Univ Hong Kong, Sch Energy & Environm, Kowloon Tong, Hong Kong, Peoples R China; Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; Ulsan Natl Inst Sci & Technol UNIST, Dept Civil Urban Earth & Environm Engn, Ulsan 44919, South Korea; Korea Polar Res Inst, Div Ocean & Atmospher Sci, Incheon 21990, South Korea; Kyungpook Natl Univ, Dept Atmospher Sci, BK21 Weather Extremes Educ & Res Team, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Atmospher Remote Sensing, Daegu 41566, South Korea ⓘ ⓘ 57882209400; 57192213405; 7202489497; 36240158700; 54789102700; 57203939102; 59227789000; 55331697200; 36169854600 ⓘ awzsseed@yonsei.ac.kr; jinsoo.kim@cityu.edu.hk; kwalker@atmosp.physics.utoronto.ca; psheese@atmosp.physics.utoronto.ca; sangseopark@unist.ac.kr; ctjin@kopri.re.kr; par0821@yonsei.ac.kr; hwanjinsong@gmail.com; zach45@yonsei.ac.kr; ⓘ REMOTE SENSING ⓘ REMOTE SENS-BASEL ⓘ 2072-4292 17 12 SCIE ENVIRONMENTAL SCIENCES;GEOSCIENCES, MULTIDISCIPLINARY;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING ⓘ 2024 4.1 18.0 ⓘ 0 0 Australian bushfire; hydrocarbon; South Pacific; ACE-FTS; MODIS ⓘ BIOMASS BURNING PLUMES; ACE-FTS; EMISSION FACTORS; FIRE EMISSIONS; BURNED AREA; TRACE GASES; SATELLITE; ALGORITHM; POLLUTION; AEROSOL ⓘ ACE-FTS; Australian bushfire; hydrocarbon; MODIS; South Pacific ⓘ Fires; Landsat; Smoke; Spectrometers; Troposphere; Atmospheric chemistry experiment; Atmospheric chemistry experiment fourier transform spectrometer; Australian bushfire; Bushfires; Fourier transform spectrometers; Hydrocarbon species; Long-term effects; Moderate-resolution imaging spectroradiometers; Satellite data; South pacific; Hydrocarbons ⓘ English 2025 2025-06-18 10.3390/rs17122092 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Translation, Cultural Adaptation, and Validation of the Korean Version of the Multimorbidity Treatment Burden Questionnaire ⓘ BackgroundPatients with hypertension and comorbidities face greater difficulties in managing their diseases than patients without comorbidities. Treatment burden is defined as individuals' effort to manage their health and the impact it has on well-being. Treatment burden is negatively associated with both health-related quality of life and adherence to treatment in patients with multimorbidity. Thus, it is important to measure the treatment burden in patients with hypertension and comorbidities with psychometrically sound instruments.PurposeIn this study, the Multimorbidity Treatment Burden Questionnaire (MTBQ) was translated and culturally adapted for use in Korea and evaluated in terms of its psychometric properties for use on patients with hypertension and comorbidities.MethodsA descriptive, cross-sectional design was used. The MTBQ was translated from English into Korean and culturally adapted using forward-backward translation. Patients with hypertension and comorbidities were recruited as participants using convenience sampling. The participants completed cognitive interviews (n = 6) and an online survey (n = 376) to examine the psychometric properties of the developed Korean instrument (K-MTBQ). Participant characteristics and item properties were described using descriptive statistics and correlation coefficients. Cronbach's alpha was used to measure internal consistency (reliability) and factor analysis was used to examine the dimensions. To assess construct validity, prespecified hypotheses were examined including: (1) the association between treatment burden and the number of comorbidities and all domains of health-related quality of life and (2) the association between the three treatment burden groups and two groups with different health-related quality of life.ResultsIn the cognitive interviews, the participants suggested adding examples to improve the clarity of two items, and reported the contents of all other items of the K-MTBQ were applicable and easily comprehensible. The Cronbach's alpha coefficient of the K-MTBQ was .93, and factor analysis suggested a one-factor model. Treatment burden was associated with the number of comorbidities and all domains of health-related quality of life. However, using the cutoff scores suggested in the original study, the difference in the proportion of patients with poor health-related quality of life was not clearly distinguished between the no-to-low treatment burden group and the medium treatment burden group.Conclusions/Implications for PracticeThe results indicate the K-MTBQ has good content validity, reliability, and construct validity for use on patients with hypertension and comorbidities. Further studies are needed to establish appropriate cutoff values for distinguishing among the different levels of treatment burden. The K-MTBQ may be used to help identify Korean patients facing difficulties managing multiple chronic conditions as well as the areas in which they require additional support. ⓘ Lee, Jihyang; Park, Da-In; Duncan, Polly; Lee, Kyoung Suk ⓘ Seoul Natl Univ, Coll Nursing, Seoul, South Korea; Kyungpook Natl Univ, Res Inst Nursing Innovat, Coll Nursing, Daegu, South Korea; Univ Bristol, Ctr Acad Primary Care, Bristol, England; Seoul Natl Univ, Res Inst Nursing Sci, Coll Nursing, Seoul, South Korea ⓘ ; Duncan, Polly/HHM-4052-2022 ⓘ 58310086200; 56883531300; 55945137400; 59661537200 ⓘ ellen92kr@snu.ac.kr; dain.park@knu.ac.kr; polly.duncan@bristol.ac.uk; kyounglee@snu.ac.kr; ⓘ JOURNAL OF NURSING RESEARCH ⓘ J NURS RES ⓘ 1682-3141 1948-965X 33 3 SCIE;SSCI NURSING ⓘ 2024 2.5 18.0 N/A ⓘ 0 0 multimorbidity; Multimorbidity Treatment Burden Questionnaire; psychometric; treatment burden ⓘ ⓘ multimorbidity; Multimorbidity Treatment Burden Questionnaire; psychometric; treatment burden ⓘ Adult; Aged; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Middle Aged; Multimorbidity; Psychometrics; Quality of Life; Reproducibility of Results; Republic of Korea; Surveys and Questionnaires; Translating; Translations; adult; aged; cross-sectional study; devices; female; human; hypertension; male; middle aged; multiple chronic conditions; procedures; psychology; psychometry; publication; quality of life; questionnaire; reproducibility; South Korea; therapy; translating (language) ⓘ English 2025 2025-06 10.1097/jnr.0000000000000674 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ UGC-Net: Uncertainty-Guided Cost Volume Optimization with Contextual Features for Satellite Stereo Matching ⓘ Disparity estimation in satellite stereo images is a highly challenging task due to complex terrain, occlusions caused by tall buildings and structures, and texture-less regions such as roads, rivers, and building roofs. Recent deep learning-based satellite stereo disparity estimation methods have adopted cascade multi-scale feature extraction techniques to address these challenges. However, the recent learning-based methods still struggle to effectively estimate disparity in the high ambiguity regions. This paper proposes a disparity estimation and refinement method that leverages variance uncertainty in the cost volume to overcome these limitations. The proposed method calculates variance uncertainty from the cost volume and generates uncertainty weights to adjust the cost volume based on this information. These weights are designed to emphasize geometric features in regions with low uncertainty while enhancing contextual features in regions with high uncertainty, such as occluded or texture-less areas. Furthermore, the proposed method introduces a pseudo volume, referred to as the 4D context volume, which extends the reference image's features during the stereo-matching aggregation step. By integrating the 4D context volume into the aggregation layer of the geometric cost volume, our method effectively addresses challenges in disparity estimation, particularly in occluded and texture-less areas. For the evaluation of the proposed method, we use the Urban Semantic 3D dataset and the WHU-Stereo dataset. The evaluation results show that the proposed method achieves state-of-the-art performance, improving disparity accuracy in challenging regions. ⓘ Jeong, Wonje; Park, Soon-Yong ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea ⓘ Park, Soon-Yong/HGV-2374-2022 ⓘ 58074469700; 7501834063 ⓘ jwj8811@knu.ac.kr; sypark@knu.ac.kr; ⓘ REMOTE SENSING ⓘ REMOTE SENS-BASEL ⓘ 2072-4292 17 10 SCIE ENVIRONMENTAL SCIENCES;GEOSCIENCES, MULTIDISCIPLINARY;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING ⓘ 2024 4.1 18.0 0 2025-06-11 ⓘ 0 0 high-resolution remote sensing images; disparity estimation; stereo matching; convolutional neural network; attention network ⓘ ⓘ attention network; convolutional neural network; disparity estimation; high-resolution remote sensing images; stereo matching ⓘ Convolutional neural networks; Tall buildings; Attention network; Contextual feature; Convolutional neural network; Disparity estimations; Estimation methods; High-resolution remote sensing images; Stereo-matching; Stereoimages; Uncertainty; Volume optimisation; Stereo image processing ⓘ English 2025 2025-05-19 10.3390/rs17101772 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A transformer-based real-time earthquake detection framework in heterogeneous environments ⓘ Earthquake detection is the base of seismological research. Recent advancements have highlighted the superior efficacy of deep learning techniques compared to conventional methods. However, deploying these techniques in highly heterogeneous environments poses significant challenges, primarily due to variations in datasets and the diversity of evaluation methods. Notably, existing models often focus on detecting the more pronounced S-waves, neglecting the crucial early detection of P-waves. To address this, our study introduces TFEQ, a transformer-based model designed for real-time earthquake detection within diverse IoT environments. Uniquely, TFEQ concurrently analyzes both P and S waves across different domains. We further substantiate TFEQ's effectiveness and its broad applicability through case studies involving MEMS sensor data collected by the CrowdQuake initiative, demonstrating its reliability and generalization capabilities. ⓘ Wu, Aming; Khan, Irshad; Kwon, Young-Woo ⓘ Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea ⓘ Kwon, Young-Woo/HGE-6607-2022; Khan, Irshad/AAN-8522-2020 ⓘ 58262125900; 36166674500; 57208480210 ⓘ ywkwon@knu.ac.kr; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 ⓘ MEMS SENSORS; SYSTEMS ⓘ ⓘ article; deep learning; diagnosis; earthquake; P wave; reliability ⓘ English 2025 2025-03-11 10.1038/s41598-024-82087-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Analysis of nationwide adverse event reports on Isoniazid and Rifampin in tuberculosis prevention and treatment in South Korea ⓘ Individuals with latent tuberculosis infection (LTBI) are at risk of progressing to active tuberculosis (TB), which remains a significant cause of death globally. Although various antiTB medications-rifampin and isoniazid-exist for treating for both LTBI and active TB, pharmacovigilance studies evaluating their adverse effects are especially scare for LTBI. Given the continued status of South Korea as having the highest TB incidence among Organization for Economic Cooperation and Development countries, this study examines drug-related adverse events (AEs) and identifies novel signals associated with rifampin or isoniazid in TB prevention and treatment in South Korea using the national AE reporting system. Analyzing data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database (KIDS-KAERS DB, 2301A0006) between 2017 and 2021, we observed that rifampin was frequently listed as a suspected drug in AE reports. Serious adverse events (SAEs), including life-threatening events and hospitalizations, were observed in LTBI as well as active TB cases when rifampin was the suspected drug. Novel signals, including QT prolongation and acne, were also identified, underscoring the importance of AE monitoring in LTBI or active TB treatment. ⓘ Ryu, Juhee; Lee, Yugyeong; Kwon, Jin-Won ⓘ Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Coll Pharm, Bk21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Res Inst Pharmaceut Sci, Daegu, South Korea ⓘ ⓘ 57208255566; 59670521500; 16202951700 ⓘ jwkwon@knu.ac.kr; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Drug-related adverse event report; Tuberculosis; Antituberculosis drugs; Rifampin; Isoniazid; Pharmacovigilance ⓘ LATENT TUBERCULOSIS; ANTITUBERCULOSIS THERAPY; INFECTION; PROLONGATION; RISK ⓘ Antituberculosis drugs; Drug-related adverse event report; Isoniazid; Pharmacovigilance; Rifampin; Tuberculosis ⓘ Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Antitubercular Agents; Child; Child, Preschool; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Isoniazid; Latent Tuberculosis; Male; Middle Aged; Pharmacovigilance; Republic of Korea; Rifampin; Tuberculosis; Young Adult; isoniazid; rifampicin; tuberculostatic agent; adolescent; adult; adverse drug reaction; child; drug therapy; epidemiology; factual database; female; human; infant; latent tuberculosis; male; middle aged; pharmacovigilance; preschool child; prevention and control; South Korea; tuberculosis; young adult ⓘ English 2025 2025-03-03 10.1038/s41598-025-91753-y ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Antimicrobial activity of cephamycins and β-lactam/β-lactamase inhibitors against ESBL-producing Escherichia coli and Klebsiella pneumoniae under standard and high bacterial inocula ⓘ This study investigated the in vitro antimicrobial activity of cephamycins and novel beta-lactam/beta-lactamase inhibitor combinations, against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae isolates. ESBL-producing blood isolates were obtained between January and May 2023. The antibiotic susceptibility of the isolates was determined by broth microdilution method using standard (105 CFU/mL) and high (107 CFU/mL) inoculum sizes. Two randomly selected ESBL-producing isolates were subjected to time-kill assays for cephamycin. More than 80% of the isolates exhibited susceptibility to cefoxitin, cefmetazole, flomoxef, ceftazidime/avibactam, cefepime/enmetazobactam and imipenem/relebactam. Ceftolozane/tazobactam demonstrated in vitro efficacy against 62.1% of the ESBL-producing isolates. At the higher inoculum size, cefoxitin, cefmetazole, flomoxef, ceftolozane/tazobactam, ceftazidime/avibactam, cefepime/enmetazobactam, and imipenem/relebactam demonstrated in vitro efficacy against 48.3%, 75.9%, 70.0%, 0%, 82.8%, 100%, 89.7% of the ESBL-producing isolates. The frequencies of the inoculum effect with cefoxitin (3.7%), cefmetazole (14.8%), flomoxef (88.9%), ceftolozane/tazobactam (96.0%), ceftazidime/avibactam (34.5%), cefepime/enmetazobactam (10.3%), and imipenem/relebactam (10.3%) were identified. With standard inoculum, cephamycins reduced bacterial growth within 2-24 h. However, high inoculum resulted in regrowth after 12 h of cephamycin exposure. Cephamycins demonstrated high in vitro activity against ESBL-producing isolates at standard inoculum sizes. However, the in vitro time-kill experiments revealed that the efficacy of cephamycins is not fully maintained at high inoculum sizes. ⓘ Wi, Yu Mi; Choi, Ji Young; Lee, Da Eun; Jun, So Hyun; Kwon, Ki Tae; Ko, Kwan Soo ⓘ Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Internal Med, Chang Won, South Korea; Sungkyunkwan Univ, Sch Med, Dept Microbiol, Suwon 16419, South Korea; Kyungpook Natl Univ Hosp, Natl Culture Collect Pathogens KNUH NCCP, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis,Kyungpook Natl Univ Chilgok Hosp, 807 Hokuk Ro, Daegu 41404, South Korea ⓘ Hwang, Soyoon/HHM-5762-2022 ⓘ 23013143100; 55722472200; 57224099074; 59702051600; 9733850500; 7202689224 ⓘ ktkwon@knu.ac.kr; ksko@skku.edu; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Extended-spectrum beta-lactamase-producing enterobacterales; Cephamycin; Inoculum effect; Cefoxitin; Cefmetazole; Flomoxef ⓘ INFECTIOUS-DISEASES SOCIETY; FLOMOXEF; ENTEROBACTERIACEAE; CARBAPENEMS; BACTEREMIA; AMERICA ⓘ Cefmetazole; Cefoxitin; Cephamycin; Extended-spectrum β-lactamase-producing enterobacterales; Flomoxef; Inoculum effect ⓘ Anti-Bacterial Agents; Azabicyclo Compounds; beta-Lactamase Inhibitors; beta-Lactamases; Cefmetazole; Cefoxitin; Ceftazidime; Cephalosporins; Cephamycins; Drug Combinations; Escherichia coli; Escherichia coli Infections; Humans; Imipenem; Klebsiella pneumoniae; Microbial Sensitivity Tests; Tazobactam; antiinfective agent; avibactam, ceftazidime drug combination; azabicyclo derivative; beta lactamase; beta lactamase inhibitor; cefmetazole; cefoxitin; ceftazidime; cephalosporin derivative; cephamycin derivative; imipenem; relebactam; tazobactam; drug combination; drug effect; drug therapy; enzymology; Escherichia coli; Escherichia coli infection; human; Klebsiella pneumoniae; metabolism; microbial sensitivity test; microbiology ⓘ English 2025 2025-03-21 10.1038/s41598-025-90762-1 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Arbuscular mycorrhizal fungus Rhizophagus irregularis enhances antioxidant system mechanisms in chickpea plants under saline conditions ⓘ Under soil saline conditions, biochemical alterations occur during plant-arbuscular mycorrhizal fungi (AMF) interactions, depending on the fungal strain involved and the intensity of the stress. This study aimed to evaluate the infectivity and efficacy of Rhizophagus irregularis by analyzing the biochemical responses it induces in chickpea (Cicer arietinum L.) cv. ʽNacional-29ʼ under 50 mM NaCl stress. Nacional-29 is a chickpea variety developed at the Institute of Fundamental Research in Tropical Agriculture (INIFAT) “Alejandro de Humboldt” and is classified as susceptible to salinity when the soil saturation extract exceeds 30 mM. The effect of an AMF strain (INCAM 11 of Rhizophagus irregularis) from the INCA collection was assessed in chickpea plants regarding root colonization, accumulation of cytocompatible osmolytes, and the activity of various antioxidant enzymes. The analysis demonstrated enhanced antioxidant defense mechanisms, a significant increase in proline accumulation in the leaves of stressed mycorrhizal plants, and a substantial reduction in lipid peroxidation, with levels even lower than those in the inoculated control plants. The applied salt stress caused a redox imbalance, leading to a reduction of POX, SOD, and APX by 35%, 20%, and 25%, respectively, while increasing free radical levels. However, the inoculated stressed plants exhibited higher levels of total soluble carbohydrates and increased catalase and glutathione reductase activity, indicating that redox homeostasis was crucial for salinity tolerance. These findings indicate that R. irregularis enhances antioxidant defense mechanisms in chickpea plants, thereby improving their salinity tolerance. This could have significant implications for agricultural practices, particularly in developing strategies to enhance crop resilience in saline soils. Arbuscular mycorrhizal fungi, such as R. irregularis, provide a sustainable solution for enhancing crop productivity in saline-affected areas, thereby contributing to food security in regions facing soil salinity challenges. © The Author(s) 2025. ⓘ Azizoglu, Ugur; Argentel-Martínez, Leandris; Peñuelas-Rubio, Ofelda; Meriño-Hernández, Yanitza; Rodríguez-Yon, Yakelin; Dell Amico-Rodríguez, José Miguel; González-Aguilera, Jorge; Shin, Jae-Ho ⓘ Department of Crop and Animal Production, Safiye Cikrikcioglu Vocational College, Kayseri University, Kayseri, Turkey, Genome and Stem Cell Research Center, Erciyes University, Kayseri, Turkey; Tecnológico Nacional de México, Instituto Tecnológico del Valle del Yaqui, Avenida Tecnológico s/n, Block 611, Sonora, Bácum, C. P. 85276, Mexico, Tecnologycal Institute of Yaqui Valley, Sonora, Bácum, C.P. 85276, Mexico; Tecnológico Nacional de México, Instituto Tecnológico del Valle del Yaqui, Avenida Tecnológico s/n, Block 611, Sonora, Bácum, C. P. 85276, Mexico; National Institute of Agricultural Sciences, Tapaste km 3½, Mayabeque, San José de las Lajas, C.P. 32700, Cuba; Mycorrhiza Laboratory, Embrapa Agrobiologia, BR 465, km 07, Bairro Ecologia, RJ, Seropédica, 23891-000, Brazil; National Institute of Agricultural Sciences, Tapaste km 3½, Mayabeque, San José de las Lajas, C.P. 32700, Cuba; Universidade Estadual de Mato Grosso do Sul, Casilandia, Brazil; School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 41566, South Korea ⓘ ⓘ 52363128100; 57202038750; 57194395312; 59716467600; 57190696758; 57356188200; 55307469600; 57224125922 ⓘ azizoglugur@gmail.com; oleinismora@gmail.com; ⓘ Plant Growth Regulation ⓘ PLANT GROWTH REGUL ⓘ 0167-6903 1573-5087 SCIE PLANT SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 ⓘ ⓘ Antioxidant enzymes; Mycorrhizae; Osmolytes; Salinity ⓘ ⓘ English Article in press 2025 10.1007/s10725-025-01315-5 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Automated interpretation of cardiotocography using deep learning in a nationwide multicenter study ⓘ Timely detection of abnormal cardiotocography (CTG) during labor plays a crucial role in enhancing fetal prognosis. Recent research has explored the use of deep learning for CTG interpretation, most studies rely on small, localized datasets or focus on outcomes less relevant to clinical practice. To address these limitations, we developed a clinically applicable model using a large-scale, nationwide CTG dataset with reliable annotations provided by a board-certified obstetrician. Our study utilized 22,522 deliveries from 14 hospitals, each including cardiotocography (CTG) recordings of up to 75 min in length. The CTG signals were segmented into 5-minute intervals, resulting in a total of 519,800 person-minutes of analyzed data. We trained and validated a deep learning model based on CTG segments for classifying normal and abnormal CTGs. In the independent test dataset, the model achieved an AUC (area under the receiver operating characteristic curve) of 0.880 and PRC (area under the precision-recall curve) of 0.625 in internal tests. External tests across three datasets achieved AUCs of 0.862, 0.895, and 0.862 and PRCs of 0.553, 0.615, and 0.601. Our study results show the potential of the deep learning for automated CTG interpretation. We will evaluate this model in future prospective studies to assess the model's clinical applicability. ⓘ Park, Chang Eun; Choi, Byungjin; Park, Rae Woong; Kwak, Dong Wook; Ko, Hyun Sun; Seong, Won Joon; Cha, Hyun-Hwa; Kim, Hyun Mi; Lee, Jisun; Seol, Hyun-Joo; Pyeon, Seungyeon; Hong, Soon-Cheol; Kang, Yun Dan; Oh, Kyung Joon; Park, Joong Shin; Kim, Young Nam; Kim, Young Ah; Kim, Yoon Ha; Kim, Gwang Jun; Kim, Miran; Chang, Hye Jin ⓘ Ajou Univ, Grad Sch Med, Dept Convergence Healthcare Med, Suwon, South Korea; Ajou Univ, Grad Sch Med, Dept Biomed Informat, Suwon, South Korea; Jeju Natl Univ Hosp, Jeju, South Korea; Ajou Univ, Sch Med, Dept Obstet & Gynecol, Suwon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Korea Univ Med, Dept Obstet & Gynecol, Seoul, South Korea; Dankook Univ, Sch Med, Dept Obstet & Gynecol, Cheonan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Obstet & Gynecol, Coll Med, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Obstet & Gynecol, Busan, South Korea; Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Obstet & Gynecol, Goyang, South Korea; Chonnam Natl Univ, Med Sch, Dept Obstet & Gynecol, Gwangju, South Korea; Chung Ang Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea ⓘ Park, Chang-Eun/AEW-4266-2022 ⓘ 59297898200; 57218405028; 59530198200; 56480108900; 37026301100; 59928458700; 59928352200; 57219838830; 57216463710; 15924081200; 57202077726; 55796042900; 56116010400; 36486865800; 57049864100; 59928295900; 59928563100; 59903083500; 59928406800; 57216813692; 56656804100 ⓘ bg9523@ajou.ac.kr; choi328328@ajou.ac.kr; veritas@ajou.ac.kr; kdw1015@gmail.com; mongkoko@catholic.ac.kr; wjseong@knu.ac.kr; chh9861@knu.ac.kr; hyunmik@gmail.com; vmariagnes@gmail.com; seolhj@khu.ac.kr; pyun0522@gmail.com; novak082@naver.com; yundan76@dankook.ac.kr; kjohmd@snubh.org; jsparkmd@snu.ac.kr; ob.youngnam@gmail.com; camanbal@paik.ac.kr; kimyh@chonnam.ac.kr; gjkim@cau.ac.kr; kmr5300@ajou.ac.kr; zzanga-94@hanmail.net; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-06-11 ⓘ 0 0 Cardiotocography; Deep learning model; Fetal monitoring ⓘ FETAL HEART-RATE ⓘ Cardiotocography; Deep learning model; Fetal monitoring ⓘ Area Under Curve; Cardiotocography; Deep Learning; Female; Heart Rate, Fetal; Humans; Pregnancy; ROC Curve; area under the curve; cardiotocography; clinical trial; deep learning; female; fetus heart rate; human; multicenter study; physiology; pregnancy; procedures; receiver operating characteristic ⓘ English 2025 2025-06-04 10.1038/s41598-025-02849-4 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population ⓘ To evaluate the incidence and risk of cardiovascular disease (CVD) among Korean patients with systemic lupus erythematosus (SLE) comparing them to diabetes patients and the general population. This nationwide cohort study focused on incident SLE patients aged over 40 years, matched with diabetes patients and the general population (1:4:4 ratio). CVD was defined as ischaemic heart disease, ischaemic stroke, and cardiac arrest. Incidence rate and incidence rate ratio (IRR) of CVD were calculated using generalised estimating equation models. The Fine-Gray model assessed risk factors for CVD in both SLE and diabetes patients. The study included 4272 incident SLE patients, 17,003 diabetes patients, and 17,088 from the general population. SLE patients had higher CVD risk compared to the general population, with adjusted IRRs of 1.99 for overall CVD. Diabetes patients showed increased CVD risk, but to a lesser extent, with an IRR of 1.39. SLE patients aged 40-59 years displayed a significantly elevated CVD risk. Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. SLE patients have a higher risk of CVD compared to the general population, more so than diabetes patients. ⓘ Han, Jung-Yong; Cho, Soo-Kyung; Jeon, Yena; Kang, Gaeun; Jung, Sun-Young; Jang, Eun Jin; Sung, Yoon-Kyoung ⓘ Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul 04763, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea ⓘ ⓘ 57220065429; 35185890800; 57209909350; 58808701500; 57207445502; 37861741600; 15754508900 ⓘ sungyk@hanyang.ac.kr; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Systemic lupus erythematosus; Cardiovascular disease; Diabetes mellitus ⓘ MYOCARDIAL-INFARCTION; MORTALITY; EVENTS; STROKE; COHORT; WOMEN ⓘ Cardiovascular disease; Diabetes mellitus; Systemic lupus erythematosus ⓘ Adult; Aged; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; Female; Humans; Incidence; Lupus Erythematosus, Systemic; Male; Middle Aged; Republic of Korea; Risk Factors; adult; aged; cardiovascular disease; cohort analysis; comparative study; complication; diabetes mellitus; epidemiology; etiology; female; human; incidence; male; middle aged; risk factor; South Korea; systemic lupus erythematosus ⓘ English 2025 2025-01-25 10.1038/s41598-025-87740-y ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions ⓘ Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. Consecutive patients with severe coronary artery calcification were enrolled, who underwent percutaneous coronary intervention (PCI) using RA between January 2010 and October 2019 at 9 tertiary centers. Direct RA was defined as the early application of RA before the balloon was expanded to a size more than or equal to 2.0 mm. The primary endpoint was the composite outcome of technical failure or severe coronary dissection (type D, E, or F) during entire procedure. Of 581 lesions, 360 (62.0%) lesions underwent direct RA. The technical success rate was higher in the direct RA group than in the indirect RA group (97.5% vs. 93.7%, p = 0.021). The primary endpoint was more frequently observed in the indirect RA group than in the direct RA group (24.4% vs. 11.9%, p < 0.001). Multivariate logistic regression analysis revealed that the risk of the primary endpoint was higher in the indirect RA group than in the direct RA group (odds ratio 2.512, 95% CI 1.547-4.078, p < 0.001). Early application of RA may reduce the incidences of in-hospital adverse events and procedure-related complications. ⓘ Lee, Kyusup; Jung, Ji-hoon; Kwon, Woojin; Kim, Dae-Won; Park, Mahn-Won; Choi, Ik Jun; Lee, Jae-Hwan; Yoon, Yong Hoon; Lee, Jang Hoon; Lee, Sang Rok; Lee, Pil Hyung; Lee, Seung-Whan; Yoo, Ki Dong; Yun, Kyeong Ho; Lee, Hyun-Jong; Her, Sung-Ho ⓘ Catholic Univ Korea, Coll Med, Cardiovasc Res Inst Intractable Dis, Seoul, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Cardiol, Seoul, South Korea; Korea Inst Toxicol, Daejeon, South Korea; Konyang Univ, Konyang Univ Hosp, Dept Anaesthesiol & Pain Med, Coll Med, Daejeon, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Cardiol, Incheon, South Korea; Chungnam Natl Univ, Sejong Hosp, Dept Cardiol, Sch Med, Sejong, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chonbuk Natl Univ Hosp, Dept Cardiol, Jeonju, South Korea; Univ Ulsan, Asan Med Ctr, Dept Cardiol, Coll Med, Seoul, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Cardiol, 93 Joonbu Daero, Seoul 16247, South Korea; Wonkwang Univ Hosp, Reg Cardiocerebrovasc Ctr, Dept Cardiovasc Med, Iksan, South Korea; Sejong Gen Hosp, Dept Internal Med, Bucheon, South Korea ⓘ Lee, Hyun Jong/ITU-5552-2023; Yun, Kyeong Ho/IYS-8810-2023 ⓘ 57204923370; 57204175011; 57031424900; 57199419487; 57751047500; 55486997300; 36066387900; 56038479700; 54581258000; 55887032200; 35201186300; 17233718400; 35082999900; 14424664600; 57202973860; 12806475600 ⓘ hhhsungho@naver.com; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Percutaneous coronary intervention; Rotational atherectomy; Complex coronary lesions; Guideline ⓘ INTERVENTION; MANAGEMENT; BAILOUT ⓘ Complex coronary lesions; Guideline; Percutaneous coronary intervention; Rotational atherectomy ⓘ Aged; Aged, 80 and over; Atherectomy, Coronary; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Retrospective Studies; Treatment Outcome; Vascular Calcification; adverse event; aged; blood vessel calcification; clinical trial; coronary artery disease; coronary atherectomy; coronary blood vessel; diagnostic imaging; female; human; male; middle aged; multicenter study; pathology; percutaneous coronary intervention; procedures; retrospective study; surgery; treatment outcome; very elderly ⓘ English 2025 2025-02-03 10.1038/s41598-025-88695-w ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clinical implications of deep learning based image analysis of whole radical prostatectomy specimens ⓘ Prostate cancer (PCa) diagnosis faces significant challenges due to its complex pathological characteristics and insufficient pathologist resources. While deep learning-based image analysis (DLIA) shows promise in enhancing diagnostic accuracy, its application to radical prostatectomy (RP) specimens remains underexplored. In this study, we evaluated the clinical feasibility and prognostic value of a DLIA algorithm for Gleason grading and tumor quantification on whole RP specimens. Using 29,646 digitized H&E-stained slides from 992 patients who underwent RP, we compared the case-level algorithm results with pathologist assessments for the International Society of Urological Pathology grade groups (GG), tumor volumes (TV), and percent tumor volumes (PTV). We also evaluated their prognostic performance in predicting biochemical progression-free survival (BPFS). Pathologists identified cancer in 986 cases and assigned GG in 980, while the DLIA algorithm identified cancer and assigned GG to all cases without omission. DLIA-assigned GG showed fair concordance with pathologist assessments (linear-weighted Cohen's kappa: 0.374) and demonstrated similar efficacy in predicting BPFS (c-index: 0.644 for DLIA vs. 0.654 for pathologists; p = 0.52). In tumor quantification, DLIA-measured TV and PTV were strongly correlated with pathologist-based measurements (Pearson's correlation coefficient: 0.830 and 0.846, respectively), but showed stronger efficacy in BPFS prediction, with c-index values of 0.657 and 0.672 compared to 0.622 and 0.641, respectively. Incorporating DLIA-derived PTV into the CAPRA-S score significantly improved its predictive accuracy for BCR (p = 0.006), increasing the c-index from 0.704 to 0.715. Our findings indicate that DLIA algorithms can enhance the accuracy of Gleason grading and tumor quantification in RP specimens, providing valuable support in clinical decision-making for PCa management. ⓘ Kwak, Tae-Yeong; Lee, Chan Ho; Park, Won Young; Ku, Ja Yoon; Jeong, Chang Wook; Hwang, Eu Chang; Choi, Seock Hwan; Cho, Joonyoung; Chang, Hyeyoon; Kim, Kyung Hwan; Kang, Byeong Jin; Kim, Sun Woo; Ha, Hong Koo ⓘ Deep Bio Inc, Seoul 08380, South Korea; Inje Univ, Busan Paik Hosp, Dept Urol, Coll Med, Busan 47392, South Korea; Seegene Med Fdn, Dept Pathol, Busan 48792, South Korea; Dongnam Inst Radiol & Med Sci, Dept Urol, Busan 46033, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Urol, Coll Med, Seoul 03080, South Korea; Chonnam Natl Univ, Dept Urol, Med Sch, Gwangju 58128, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41404, South Korea; Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Urol, Busan 49241, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan 49241, South Korea ⓘ Ha, Hong/W-1873-2019; Hwang, Eu/K-3680-2019; Park, Won Young/ABD-7597-2021 ⓘ 57207930927; 55855972900; 56070095500; 55373044600; 59528288200; 8441681300; 9742645500; 57211705578; 42961136900; 57215819741; 57210944155; 57207939654; 36854637400 ⓘ hongkooha@pusan.ac.kr; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Prostate cancer; Radical prostatectomy; Gleason grading; Tumor quantification; Deep learning; Digital pathology ⓘ ISUP CONSENSUS CONFERENCE; INTERNATIONAL-SOCIETY; ARTIFICIAL-INTELLIGENCE; TUMOR VOLUME; CANCER; BIOPSIES; DIAGNOSIS; GRADE ⓘ Deep learning; Digital pathology; Gleason grading; Prostate cancer; Radical prostatectomy; Tumor quantification ⓘ Aged; Algorithms; Deep Learning; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neoplasm Grading; Prognosis; Prostate; Prostatectomy; Prostatic Neoplasms; Tumor Burden; aged; algorithm; cancer grading; deep learning; diagnostic imaging; human; image processing; male; middle aged; pathology; procedures; prognosis; prostate; prostate tumor; prostatectomy; surgery; tumor burden ⓘ English 2025 2025-03-31 10.1038/s41598-025-95267-5 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Comparative analysis of biodiversity, physiology, and anatomical adaptations in riparian flora exposed to industrial pollution stress ⓘ Anthropogenic activities such as industrial pollution of water bodies possess threat to floras leading to extinction and endangerment. This study investigates the impact of industrial pollution on vegetation along River Chenab and its associated drains. Rivers and channels transporting industrial effluents have been determined to be significantly contaminated. The contamination was evidenced by the acidic and alkaline nature of industrial effluents, salinity, total dissolved solids, and the sodium absorption ratio. The research revealed that the pollution in the region severely impacts the native vegetation, resulting in a marked decline in density, frequency, relative density, and relative frequency across 10 sites, including three drain sites and one non-polluted site. Four plant species, Calotropis procera, Eclipta alba, Phyla nodiflora, and Ranunculus sceleratus exhibited tolerance to pollution and were present at all sites during all seasons. Anatomical modifications, such as increased root aerenchyma and vascular bundles, enabled these plants to thrive in polluted environments. The study highlights the importance of these species in phytoremediation and their potential for use in restoring degraded ecosystems. ⓘ Gatasheh, Mansour K.; Abbas, Toqeer; Shaffique, Shifa; Kang, Sang-Mo; Lee, In-Jung; Shah, Anis Ali ⓘ King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia; Univ Sargodha, Dept Bot, Sargodha, Pakistan; Kyungpook Natl Univ, Dept Appl Biosci, Seoul, South Korea; Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Punjab, Pakistan ⓘ Abbas, Toqeer/KHY-4557-2024; Gatasheh, Mansour/AAP-9414-2021; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; shaffique, shifa/KUC-7102-2024; Shah, Dr. Anis/AAV-2232-2020 ⓘ 15742571400; 57202833813; 57203898867; 56189696900; 16425830900; 57211606140 ⓘ toqeerabbas01@gmail.com; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 4.56 2025-05-07 ⓘ 1 3 Biodiversity; Heavy metals; Industrial pollution; Root arenchyma; Species density; Species frequency ⓘ ⓘ Biodiversity; Heavy metals; Industrial pollution; Root arenchyma; Species density; Species frequency ⓘ Adaptation, Physiological; Biodegradation, Environmental; Biodiversity; Ecosystem; Plant Roots; Plants; Rivers; Stress, Physiological; Water Pollutants, Chemical; adverse event; biodiversity; bioremediation; comparative study; drug effect; ecosystem; growth, development and aging; metabolism; physiological adaptation; physiological stress; plant; plant root; river; toxicity; water pollutant ⓘ English 2025 2025-01-23 10.1038/s41598-025-87396-8 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Comparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest ⓘ There is insufficient evidence regarding the use of second-line vasopressors following norepinephrine administration in the post-resuscitation management of patients with out-of-hospital cardiac arrest (OHCA). Therefore, this study aimed to investigate the survival outcomes between norepinephrine plus epinephrine and norepinephrine plus vasopressin as vasopressor combinations after return of spontaneous circulation (ROSC) in patients with OHCA. This retrospective observational study included data from a prospective multicenter registry. Adult patients with OHCA who achieved sustained ROSC and received vasopressor combinations of norepinephrine plus epinephrine or norepinephrine plus vasopressin were included in the study. The variable of interest was the vasopressor combination either norepinephrine plus epinephrine or norepinephrine plus vasopressin within 24 h from sustained ROSC. The primary outcome was survival to discharge. Multivariable logistic regression analysis was conducted. Between October 2015 and June 2024, 901 patients were analyzed. Survival to discharge and good neurological outcome were significantly higher in the group with norepinephrine plus epinephrine than in the group with norepinephrine plus vasopressin (17.0% vs. 9.1%, p = 0.001, and 8.1% vs. 3.2%, p = 0.002, respectively). Norepinephrine plus vasopressin was independently associated with worse survival to discharge and neurological outcome compared to norepinephrine plus epinephrine, after adjusting for potential confounders (adjusted odds ratio [aOR] 0.454, 95% confidence interval [CI] 0.277–0.746, p = 0.002 and aOR 0.346, 95% CI 0.150–0.794, p = 0.012, respectively). These findings were maintained in multiple regression models and sensitivity analyses. Norepinephrine plus epinephrine administration within 24 h from sustained ROSC showed better survival to discharge than norepinephrine plus vasopressin in patients with OHCA. © The Author(s) 2025. ⓘ Ahn, Sejoong; Jin, Bo-Yeong; Lee, Sukyo; Park, Jong-Hak; Cho, Hanjin; Moon, Sungwoo; Kim, Ji Hoon; Jung, Jin Hee; Kim, Won Young; Park, Jeong Ho; Shin, Sang; Hwang, Sung Oh; Hwang, Seung Sik; Cho, Gyu Chong; Na, Sang Hoon; Song, Kyung Jun; Chung, Sung Phil; Hwang, Yun Jeong; Ko, Jai Woog; Ha, Chul Min; Choi, Dong Sun; Shin, Hyun Goo; Kim, Chang Sun; Kim, Tae-Kwon; Jin, Sang Chan; Kang, Eui Hyuk; Kwon, Joon-Myoung; Ko, Seo Young; Song, Sung Wook; Moon, Yi Sang; Kim, Won; Lee, Sang Bong; Jeong, Jin Hee; Lee, Ju Taek; Park, Young Tae; Yoon, Jae Chol; Jung, Tae Oh; Kim, Yong Oh; Choi, Han Joo; Park, Gwan Jin; Kim, Sang Chul; Park, Kyung Sook; Eob, An Mu; Shin, Myoung Cheol; Ohk, Taek Geun; Jung, Woo Jin; Cha, Kyoung Chul; Park, Hang A.; Park, Ju Ok; Yang, Won Seok; Ha, Sang Ook; Lee, Yong Hee; Bae, Jin Kun; Wi, Dai Han; Park, Myung Hee; Park, Jin Sik; Kim, Young Sik; Lee, Kyeong Min; Lee, Sang Hun; Lee, Seung Cheol; Ahn, Ki Ok; Kim, In Byung; Park, Sung Min; Jo, You Hwan; Rhee, Bang Shill; Choi, Wook Jin; Ahn, Ryeok; Lee, Jae Kwang; Park, Sung Soo; Jeong, Wonjoon; Lee, Jin Woong; Kim, Sun Pyo; Kim, Chong Sun; Yun, Sung Hyun; Woo, Jae-Hyug; Yang, Hyuk Jun; Ahn, Jae Yun; Ryu, Hyun Wook; Yang, Wook Tae; Park, Sung Wook; Lee, Jun Cheol; Oh, Jae Hoon; Jang, Yong Soo; Kang, Gu Hyun; Cho, Youngsuk; Hwang, Hyuna; Kong, Tae Young; Choi, Arom; Park, Yoo Seok; Kim, Hahn Bom; Park, Keun Hong; Lee, Hui Jai; Shin, Jong Whan; Kim, Youn Jung; Lee, Gun Tak; Sim, Min Seob; Han, Kap Su; Kim, Su Jin; Yoon, Young Hoon; Choi, Sung Hyuk; Jeong, Ki Young; Lee, Jong Seok; Park, Sang O.; Lee, Young Hwan; Choi, Phil Cho; Han, Sang Kuk ⓘ Department of Emergency Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Gyeonggi, Ansan, 15355, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea, BK21 FOUR Biomedical Science Program, Seoul National University, Seoul, South Korea; Department of Emergency Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Gyeonggi, Ansan, 15355, South Korea; Department of Emergency Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Gyeonggi, Ansan, 15355, South Korea; Department of Emergency Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Gyeonggi, Ansan, 15355, South Korea; Department of Emergency Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Gyeonggi, Ansan, 15355, South Korea; Yonsei University Severance Hospital, Seoul, South Korea; SMG-SNU Boramae Medical Center, Seoul, South Korea; Asan Medical Center, Seoul, South Korea; Seoul National University Hospital, Seoul, South Korea; Seoul National University Hospital, Seoul, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Seoul National University, Seoul, South Korea; Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea; Seoul National University Hospital, Seoul, South Korea; SMG-SNU Boramae Medical Center, Seoul, South Korea; Yonsei University Gangnam Severance Hospital, Seoul, South Korea; Yongin Severance Christian Hospital, Yongin, South Korea; Yongin Severance Christian Hospital, Yongin, South Korea; Hanil General Hospital, Seoul, South Korea; Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, South Korea; Hanyang University Guri Hospital, Guri, South Korea; Hanyang University Guri Hospital, Guri, South Korea; Keimyung University Dongsan Medical Center, Daegu, South Korea; Keimyung University Dongsan Medical Center, Daegu, South Korea; Mediplex Sejong Hospital, Bucheon, South Korea; Mediplex Sejong Hospital, Bucheon, South Korea; Jeju National University Hospital, Jeju, South Korea; Jeju National University Hospital, Jeju, South Korea; Cheju Halla General Hospital, Jeju, South Korea; Cheju Halla General Hospital, Jeju, South Korea; Gyeongsang National University Hospital, Jinju, South Korea; Gyeongsang National University Hospital, Jinju, South Korea; Dongguk University Gyeongju Hospital, Gyeongju, South Korea; Dongguk University Gyeongju Hospital, Gyeongju, South Korea; Chonbuk National University Hospital, Jeonju, South Korea; Chonbuk National University Hospital, Jeonju, South Korea; Dankook University Hospital, Cheonan, South Korea; Dankook University Hospital, Cheonan, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, South Korea; Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, South Korea; Kangwon National University Hospital, Chuncheon, South Korea; Kangwon National University Hospital, Chuncheon, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea; Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea; Hallym University Pyeongchon Sacred Heart Hospital, Anyang, South Korea; Hallym University Pyeongchon Sacred Heart Hospital, Anyang, South Korea; Cha University Bundang Medical Center, Seongnam, South Korea; Cha University Bundang Medical Center, Seongnam, South Korea; Wonkwang University Sanbon Hospital, Gunpo, South Korea; Sejong Hospital, Bucheon, South Korea; Sejong Hospital, Bucheon, South Korea; Bundang Jesaeng Hospital, Seongnam, South Korea; Dongguk University Ilsan Hospital, Goyang, South Korea; Dongguk University Ilsan Hospital, Goyang, South Korea; Dongguk University Ilsan Hospital, Goyang, South Korea; Myongji Hospital, Goyang, South Korea; Myongji Hospital, Goyang, South Korea; Seoul National University Bundang Hospital, Seongnam, South Korea; Seoul National University Bundang Hospital, Seongnam, South Korea; Ajou University Hospital, Suwon, South Korea; Ulsan University Hospital, Ulsan, South Korea; Ulsan University Hospital, Ulsan, South Korea; Konyang University Hospital, Daejeon, South Korea; Konyang University Hospital, Daejeon, South Korea; Chungnam National University Hospital, Daejeon, South Korea; Chungnam National University Hospital, Daejeon, South Korea; Chosun University Hospital, Gwangju, South Korea; Catholic Kwandong University International St. Mary’s Hospital, Incheon, South Korea; Catholic Kwandong University International St. Mary’s Hospital, Incheon, South Korea; Gachon University Gil Medical Center, Incheon, South Korea; Gachon University Gil Medical Center, Incheon, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Pusan National University Hospital, Busan, South Korea; Pusan National University Hospital, Busan, South Korea; Hanyang University Seoul Hospital, Seoul, South Korea; Hanyang University Seoul Hospital, Seoul, South Korea; Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea; Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea; Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea; Yonsei University Gangnam Severance Hospital, Seoul, South Korea; Yonsei University Gangnam Severance Hospital, Seoul, South Korea; Yonsei University Severance Hospital, Seoul, South Korea; Yonsei University Severance Hospital, Seoul, South Korea; Seoul Medical Center, Seoul, South Korea; Seoul Medical Center, Seoul, South Korea; SMG-SNU Boramae Medical Center, Seoul, South Korea; SMG-SNU Boramae Medical Center, Seoul, South Korea; Asan Medical Center, Seoul, South Korea; Samsung Medical Center, Seoul, South Korea; Samsung Medical Center, Seoul, South Korea; Korea University Anam Hospital, Seoul, South Korea; Korea University Anam Hospital, Seoul, South Korea; Korea University Guro Hospital, Seoul, South Korea; Korea University Guro Hospital, Seoul, South Korea; Kyung Hee University Hospital, Seoul, South Korea; Kyung Hee University Hospital, Seoul, South Korea; Konkuk University Medical Center, Seoul, South Korea; Konkuk University Medical Center, Seoul, South Korea; Kangbuk Samsung Medical Center, Seoul, South Korea; Kangbuk Samsung Medical Center, Seoul, South Korea ⓘ ⓘ 57219389954; 56998094300; 57398230400; 57196407523; 55454288400; 8725859700; 57194684393; 57199984314; 57246488900; 57222635486; 59908781300; 57202063517; 14066254900; 26429141500; 8692979300; 59750917300; 57293073100; 59750917400; 59751070200; 59751520600; 59751520700; 57193806427; 55520496300; 57226863363; 57205700670; 59854547600; 59750917500; 57200967790; 54407727200; 59751220100; 59751673700; 59751962800; 59751520800; 59751962900; 59751070300; 59464488300; 57221906570; 57207116214; 57198427159; 57193389046; 7601581324; 59751673800; 57221906944; 55947981300; 54382290300; 59657709600; 39860962000; 57051645300; 57196406548; 59751220200; 59751817100; 59751375800; 56514516500; 59617975500; 59751520900; 55328611600; 57221919703; 59750917700; 57192279003; 58376382200; 23975564100; 57220758869; 59750917800; 57223985329; 57226145316; 59585465000; 37664458300; 57219387841; 59751817200; 56159113900; 59333447300; 56049988200; 59751673900; 57221914773; 56915224700; 14523907200; 59750917900; 59751674000; 57941781100; 36668928000; 57093128600; 53878311700; 36468655500; 57208187938; 55234333500; 59751963000; 57190857780; 57203834959; 18134244600; 54967955200; 57221912396; 37665247900; 57214228643; 35280110200; 57200128091; 26645185500; 56660189900; 57196044127; 7402126765; 15759087700; 57195055265; 59727399100; 53464106200; 57203798768; 35147471400; 58598285500 ⓘ yg9912@korea.ac.kr; ⓘ Scientific Reports ⓘ SCI REP-UK ⓘ 2045-2322 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 ⓘ ⓘ Cardiac arrest; Epinephrine; Norepinephrine; Post-resuscitation management; Vasopressin; Vasopressor combination ⓘ Aged; Cardiopulmonary Resuscitation; Epinephrine; Female; Humans; Male; Middle Aged; Norepinephrine; Out-of-Hospital Cardiac Arrest; Registries; Retrospective Studies; Return of Spontaneous Circulation; Treatment Outcome; Vasoconstrictor Agents; Vasopressins; epinephrine; noradrenalin; vasoconstrictor agent; vasopressin derivative; aged; clinical trial; comparative study; drug effect; drug therapy; female; human; male; middle aged; mortality; multicenter study; out of hospital cardiac arrest; procedures; register; resuscitation; retrospective study; return of spontaneous circulation; treatment outcome ⓘ English Final 2025 10.1038/s41598-025-96857-z ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Dynamic biomarkers and Cox regression with time-dependent covariate for mortality prediction in severe fever with thrombocytopenia syndrome ⓘ Severe fever with thrombocytopenia syndrome (SFTS) is a fatal tick-borne infectious disease that lacks effective treatments. Dynamic analysis that reflects changes in the SFTS patient's condition is needed. This study aimed to evaluate the time-dependent predictive performance of key biomarkers using a time-dependent Cox regression model. A retrospective multicenter cohort study was conducted on 440 SFTS patients hospitalized in South Korea between 2013 and 2024. Time-dependent Cox regression and time-dependent receiver operating characteristic (ROC) analyses were applied to assess the prognostic value of Blood Urea Nitrogen (BUN), Prothrombin Time (PT), and Activated Partial Thromboplastin Time (aPTT). Missing data were handled using multiple imputation. aPTT consistently demonstrated high predictive accuracy (AUC > 0.90) throughout the disease course, indicating its sustained role in coagulopathy. PT exhibited strong early-stage predictive power (AUC = 0.86 on day 2) but declined over time, reflecting its utility for early monitoring. BUN showed a progressive increase in predictive performance (AUC = 0.70 on day 2 to AUC = 0.78 on day 8), supporting its relevance in later stages of disease progression. Non-survivors exhibited significantly higher levels of BUN, PT, and aPTT compared to survivors. This study demonstrates the utility of time-dependent analysis for evaluating dynamic biomarker changes in SFTS patients. aPTT is a robust predictor throughout the disease course, while PT is valuable for early-stage assessment and BUN for later-stage management. These findings suggest the importance of integrating dynamic biomarker monitoring into clinical decision-making to improve prognosis in SFTS patients. ⓘ Woo, Hyun Ji; Heo, Sang Taek; Yoo, Jeong Rae; Kim, Misun; Oh, Jaeseong; Bae, In-Gyu; Bae, Sohyun; Yoon, Young-Ran; Hwang, Jeong-Hwan; Hyun, Miri; Kim, Hyun ah; Jung, Sook In; Kwon, Ki Tae; Hwang, Soyoon; Kim, Uh Jin; Kang, Gaeun; Kim, Young Jun; Yun, Ji Hyun; Kim, Tae-Eun; Kwon, Tae-Kyu; Kim, Min-Gul ⓘ Jeonbuk Natl Univ, Grad Sch, Dept Healthcare Engn, Jeonju, South Korea; Nanum Space Co Ltd, Jeonju, Jeonbuk, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Jeju, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Sch Med, Dept Pharmacol, Jeju, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Sch Med, Dept Internal Med Div Hematol & Oncol, Jinju, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Jinju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Clin Pharmacol, Daegu, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Med Sch, Dept Internal Med,Div Infect Dis, Jeonju, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu 42601, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Internal Med,Div Infect Dis, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Internal Med,Div Infect Dis, Gwangju, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Pharmacol,Div Clin Pharmacol, Gwangju 61469, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Div Infect Dis, Iksan, South Korea; Konkuk Univ, Med Ctr, Sch Med, Dept Internal Med,Div Infect Dis, Seoul, South Korea; Konkuk Univ, Med Ctr, Dept Clin Pharmacol, Seoul, South Korea; Jeonbuk Natl Univ, Coll Engn, Div Biomed Engn, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Med Sch, Dept Pharmacol, Jeonju, South Korea ⓘ Yoon, Young-Ran/GLT-0172-2022; JUNG, SOOK IN/AGO-2862-2022; Yoo, Jeong Rae/KLY-3842-2024; Hwang, Soyoon/HHM-5762-2022 ⓘ 57431722600; 9737963500; 56067275200; 57203688543; 56506092000; 7004882611; 57219699506; 59813849800; 35085173600; 55927698200; 57059615500; 7403676835; 9733850500; 57203160675; 55606990600; 55224155000; 56658074800; 56506216300; 7407122618; 13002664800; 38260938400 ⓘ mgkim@jbnu.ac.kr; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 0 0 Severe fever with thrombocytopenia syndrome; Time-Dependent covariate; Dynamic biomarkers; Mortality prediction ⓘ BUNYAVIRUS; RISK ⓘ Dynamic biomarkers; Mortality prediction; Severe fever with thrombocytopenia syndrome; Time-Dependent covariate ⓘ Aged; Biomarkers; Blood Urea Nitrogen; Female; Humans; Male; Middle Aged; Partial Thromboplastin Time; Prognosis; Proportional Hazards Models; Prothrombin Time; Republic of Korea; Retrospective Studies; ROC Curve; Severe Fever with Thrombocytopenia Syndrome; biological marker; aged; blood; clinical trial; epidemiology; female; human; male; middle aged; mortality; multicenter study; partial thromboplastin time; prognosis; proportional hazards model; prothrombin time; receiver operating characteristic; retrospective study; severe fever with thrombocytopenia syndrome; South Korea; urea nitrogen blood level ⓘ English 2025 2025-03-18 10.1038/s41598-025-94416-0 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Efficacy of malic and tartaric acid in mitigation of cadmium stress in Spinacia oleracea L. via modulations in physiological and biochemical attributes ⓘ The increasing level of cadmium (Cd) contamination in soil due to anthropogenic actions is a significant problem. This problem not only harms the natural environment, but it also causes major harm to human health via the food chain. The use of chelating agent is a useful strategy to avoid heavy metal uptake and accumulation in plants. In this study, randomized design pot experiment was conducted to evaluate potential role of malic acid (MA) and tartaric acid (TA) foliar spray to mitigate Cd stress in Spinacia oleracea L plants. For Cd stress, S. oleracea plants were treated with CdCl2 solution (100 mu M). For control, plants were given distilled water. One week after Cd stress, MA and TA foliar spray was employed at concentration of 100 and 150 mu M for both. The results of this study revealed that Cd stress (100 mu M) significantly reduced growth attributes, photosynthetic pigments and related parameters and gas exchange attributes. Cadmium stress also stimulated antioxidant defense mechanism in S. oleracea. Cd stressed plants had elevated levels of Cd metal ions in root and consumable parts (i.e. leaves) and caused severe oxidative damages in the form of increased lipid peroxidation and electrolytic leakage. MA and TA supplements at both low and high levels (100 and 150 mu M) effectively reversed the devastating effects of Cd stress and improved growth, photosynthesis and defense related attributes of S. oleracea plants. These supplements also prevented excessive accumulation of Cd metal ions as indicated by lowered Cd metal contents in MA and TA treated plants. These findings demonstrated that MA and TA treatments can potentially reduce Cdl induced phytotoxicity in plants by reducing its uptake and enhancing photosynthesis and defense related parameters. ⓘ Shabbir, Ansa; Shah, Anis Ali; Usman, Sheeraz; Ahmed, Shakil; Kaleem, Muhammad; Shafique, Shiffa; Gatasheh, Mansour K. ⓘ Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Pakistan; Univ Punjab, Inst Bot, Lahore, Pakistan; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia ⓘ Shah, Dr. Anis/AAV-2232-2020; Usman, Sheeraz/KZU-1594-2024; Gatasheh, Mansour/AAP-9414-2021 ⓘ 59333264700; 57211606140; 58199413800; 57209192993; 57225140809; 59333264800; 15742571400 ⓘ anisalibot@gmail.com; miansheerazusman@gmail.com; ⓘ SCIENTIFIC REPORTS ⓘ SCI REP-UK ⓘ 2045-2322 15 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 3.9 18.1 0 2025-05-07 ⓘ 2 2 Abiotic stresses; Antioxidants; Chelation; Heavy metals; Organic acids; Phytoremediation ⓘ PLANT-GROWTH; ASSISTED PHYTOREMEDIATION; FOLIAR APPLICATION; OXIDATIVE STRESS; ORGANIC-ACIDS; TOXICITY; PHYTOEXTRACTION; PEROXIDASE; RICE; GLYCINEBETAINE ⓘ Abiotic stresses; Antioxidants; Chelation; Heavy metals; Organic acids; Phytoremediation ⓘ Antioxidants; Cadmium; Lipid Peroxidation; Malates; Oxidative Stress; Photosynthesis; Plant Leaves; Plant Roots; Soil Pollutants; Spinacia oleracea; Stress, Physiological; Tartrates; antioxidant; cadmium; malic acid; tartaric acid; drug effect; growth, development and aging; lipid peroxidation; metabolism; oxidative stress; photosynthesis; physiological stress; plant leaf; plant root; soil pollutant; spinach; toxicity ⓘ English 2025 2025-01-27 10.1038/s41598-025-85896-1 ⓘ 바로가기 바로가기 바로가기 바로가기
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