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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Performance and Stability of Polymer:Nonfullerene Solar Cells with 100 °C-Annealed Electron-Collecting Combination Layers ⓘ Inverted-type organic solar cells, fabricated with low-temperature-processed combination layers of hybrid electron-collecting buffer layers (ECBLs) consisting of zinc oxide (ZnO) and poly(2-ethyl-2-oxazoline) (PEOz) and additional PEOz interlayers, showed improved performance and stability. The ZnO:PEOz precursor films with various PEOz compositions (0-12 wt %) were prepared and thermally treated at 100 degrees C, leading to the ECBLs on which the PEOz interlayers were subsequently deposited before coating of polymer:nonfullerene bulk heterojunction layers. Results showed that the power conversion efficiency of solar cells reached approximately 9.38 and 10.11 % (average) in case of the ZnO/PEOz and ZnO:PEOz(6 wt % PEOz)/PEOz combination layers, respectively, despite the low-temperature thermal annealing process. A continuous irradiation test for 12 h under one sun condition (air mass 1.5G, 100 mW cm(-2)) disclosed that the devices with the ZnO:PEOz(6 wt % PEOz)/PEOz combination layers were more stable than those with the ZnO/PEOz layers. ⓘ Lee, Woongki; Kim, Hwajeong; Lee, Chulyeon; Lee, Sooyong; Kim, Taehoon; Kim, Youngkyoo ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, KNU Inst Nanophoton Applicat KINPA, Dept Chem Engn,Organ Nanoelect Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, Prior Res Ctr, Res Inst Environm Sci & Technol, Daegu 41566, South Korea ⓘ ⓘ 59041346100; 15520531700; 56354831300; 55421486100; 57218650958; 10340424400 ⓘ ykimm@knu.ac.kr; ⓘ CHEMSUSCHEM ⓘ CHEMSUSCHEM ⓘ 1864-5631 1864-564X 14 17 SCIE CHEMISTRY, MULTIDISCIPLINARY;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY ⓘ 2021 9.14 16.5 0 2025-07-30 ⓘ 1 1 interlayers; low-temperature annealing; organic solar cells; photovoltaics; stability ⓘ CATHODE INTERLAYER; TRANSPORT LAYER; DOPED ZNO; EFFICIENCY; FABRICATION; MODULATION ⓘ interlayers; low-temperature annealing; organic solar cells; photovoltaics; stability ⓘ ⓘ English 2021 2021-09-06 10.1002/cssc.202100841 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Editorial Material ⓘ Preface to the Special Issue of ChemSusChem on Advanced Organic Solar Cells ⓘ Organic solar cells have garnered much interest as an Earth-abundant and low-energy-production renewable energy source. In their Editorial to the Special Issue on Advanced Organic Solar Cells, Guest Editors Christoph Brabec, Martin Heeney, Youngkyoo Kim, and Christine Luscombe introduce this exciting field and discuss some of the Special Issue's contents. ⓘ Brabec, Christoph J.; Heeney, Martin; Kim, Youngkyoo; Luscombe, Christine K. ⓘ Friedrich Alexander Univ Erlangen Nurnberg, Inst Mat Elect & Energy Technol, Martensstr 7, D-91058 Erlangen, Germany; Helmholtz Inst Erlangen Nurnberg Renewable Energy, Immerwahrstr 2, D-91058 Erlangen, Germany; Imperial Coll London, Ctr Processable Elect, Dept Chem, White City Campus, London W12 0BZ, England; Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Dept Chem Engn, Sch Appl Chem Engn,Organ Nanoelect Lab, Daegu 41566, South Korea; Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA; Univ Washington, Mol Engn & Sci Inst, Seattle, WA 98195 USA; Univ Washington, Dept Chem, Seattle, WA 98195 USA ⓘ ; Brabec, Christoph/N-1897-2013; Heeney, Martin/O-1916-2013; Luscombe, Christine/U-9771-2019 ⓘ 55243713700; 6701353187; 10340424400; 8984155600 ⓘ christoph.brabec@fau.de;m.heeney@imperial.ac.uk;ykimm@knu.ac.kr;luscombe@uw.edu; ⓘ CHEMSUSCHEM ⓘ CHEMSUSCHEM ⓘ 1864-5631 1864-564X 14 17 SCIE CHEMISTRY, MULTIDISCIPLINARY;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY ⓘ 2021 9.14 16.5 1.16 2025-07-30 ⓘ 2 2 donor-acceptor systems; nonfullerene acceptors; polymers; renewable energy; solar cells ⓘ ⓘ donor-acceptor systems; nonfullerene acceptors; polymers; renewable energy; solar cells ⓘ ⓘ English 2021 2021-09-06 10.1002/cssc.202101600 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Topical Application of Synthetic Hormones Terminated Reproductive Diapause of a Univoltine Weed Biological Control Agent ⓘ Simple Summary Yellow starthistle (Centaurea solstitialis) is an invasive annual plant that has infested multi-million ha in the western United States, causing multi-billion dollars of losses and management costs. The rosette weevil (Ceratapion basicorne) has recently been approved for biological control of this weed. However, this weevil reproduces only once a year, which hinders mass-rearing for release. Here, we tested whether insect hormones can break the reproductive diapause of female weevils. We found that applying two insect hormones, 20E and methoprene, can consistently terminate diapause of female weevils to enable them to lay eggs. Thus, topically applying insect hormones could be used to induce females to lay eggs at any time of year, which would permit rearing more than one generation per year. This could greatly increase the number of weevils produced per year in a mass-rearing program to accelerate the release of rosette weevils to help suppress yellow starthistle in the United States. These insects would revert to having one generation per year after release in synchrony with their host plant. Classical biological control is an important method for controlling invasive alien weeds. Univoltine insects can be highly effective biological control agents of annual weeds because they are well synchronized with their host plant. However, having only one generation per year makes it difficult and slow to multiply them in the laboratory for initial field releases. If it were possible to terminate reproductive diapause early, then we could rear multiple generations per year, which would greatly increase annual production. We used a recently approved biocontrol agent, Ceratapion basicorne (a univoltine weevil), for yellow starthistle (Centaurea solstitialis) as a model system to study the use of two insect hormones, 20-hydroxyecdysone (20E) and methoprene, to terminate reproductive diapause. Methoprene (1 mu g applied topically) terminated reproductive diapause of female weevils, whereas doses of 0.0, 0.01 and 0.1 mu g did not. The combination of methoprene and 20E had a stronger effect and induced an increase in eggs (1.51 +/- 0.16 eggs/day, mean +/- SE) compared with a methoprene only group (1.00 +/- 0.13 eggs/day), and a control group (0.21 +/- 0.04 eggs/day). Thus, topical application of these hormones should enable us to rear the weevil out of its normal season and produce more than one generation per year, which will increase productivity of mass-rearing it for field release. Once released in the field, the insect would continue as a univoltine agent that is well-synchronized with its host plant. ⓘ Park, Ikju; Smith, Lincoln ⓘ USDA ARS, Invas Species & Pollinator Hlth Res Unit, Western Reg Res Ctr, 800 Buchanan St, Albany, CA 94706 USA; Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea ⓘ ⓘ 57200320797; 22977509400 ⓘ ikju.park@usda.gov;link.smith@usda.gov; ⓘ INSECTS ⓘ INSECTS ⓘ 2075-4450 12 9 SCIE ENTOMOLOGY ⓘ 2021 3.141 16.5 0.45 2025-07-30 ⓘ 4 4 20-hydroxyecdysone (20E); methoprene; Ceratapion basicorne; Centaurea solstitialis; yellow starthistle ⓘ CERATAPION-BASICORNE COLEOPTERA; ANTHONOMUS-POMORUM COLEOPTERA; APPLE BLOSSOM WEEVIL; YELLOW STARTHISTLE; HOST-RANGE; METHOPRENE; 20-HYDROXYECDYSONE; APIONIDAE; LEPIDOPTERA; RELEASE ⓘ 20-hydroxyecdysone (20E); Centaurea solstitialis; Ceratapion basicorne; Methoprene; Yellow starthistle ⓘ ⓘ English 2021 2021-09 10.3390/insects12090834 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Two-Dimensional Organic/Inorganic Hybrid Nanosheet Electrodes for Enhanced Electrical Conductivity toward Stable and High-Performance Sodium-Ion Batteries ⓘ To investigate the effect of electrical conductivity on the energy-storage characteristics of anode materials in sodium-ion batteries, covalent organic nanosheets (CONs) are hybridized with highly conductive graphene nanosheets (GNs) via two different optimized synthesis routes, that is, reflux and solvothermal methods. The reflux-synthesized hybrid shows a well-overlapped 2D structure, whereas the solvothermally prepared hybrid forms a segregated phase in which the contact area between the CONs and GNs is reduced. These two hybrids synthesized by facile methods are fully characterized, and the results reveal that their energy-storage properties can be significantly improved by enhancing the electrical conductivity via the formation of a well-overlapped structure between CONs and GNs. The discharge capacity and rate capability of the reflux-synthesized hybrid was considerably larger than that of the bare CONs, highlighting that the improvement in the charge-carrier transport properties can improve the accessibility of Na ions to the surface of the hybrids. This synthetic methodology can be extended to the fabrication of high-performance anodes for Na-ion batteries. ⓘ Lee, Minseop; Kim, Min-Sung; Oh, Jae-Min; Park, Jin Kuen; Paek, Seung-Min ⓘ Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea; Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, Gyeonggi Do, South Korea ⓘ Paek, Seung-Min/E-4667-2011; Lee, Minseop/JVZ-7552-2024 ⓘ 57201550392; 57201126868; 7402155053; 55085701500; 7102686289 ⓘ jaemin.oh@dongguk.edu;jinkpark@hufs.ac.kr;smpaek@knu.ac.kr; ⓘ CHEMSUSCHEM ⓘ CHEMSUSCHEM ⓘ 1864-5631 1864-564X 14 16 SCIE CHEMISTRY, MULTIDISCIPLINARY;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY ⓘ 2021 9.14 16.5 0.6 2025-07-30 ⓘ 17 17 covalent organic nanosheets; graphene; hybridization; sodium-ion batteries; structure-property relationships ⓘ COVALENT ORGANIC NANOSHEETS; REDUCED GRAPHENE OXIDE; ANODE MATERIALS; GRAPHITE OXIDE; LITHIUM; FRAMEWORKS; REDUCTION; STORAGE; POLYMER; IR ⓘ covalent organic nanosheets; graphene; hybridization; sodium-ion batteries; structure-property relationships ⓘ Anodes; Carrier transport; Electric conductivity; Energy storage; Metal ions; Nanosheets; Discharge capacities; Electrical conductivity; Energy storage characteristics; Energy storage properties; High-performance anodes; Nanosheet electrodes; Organic/Inorganic hybrids; Synthetic methodology; Sodium-ion batteries ⓘ English 2021 2021-08-23 10.1002/cssc.202100545 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ultrasound-Guided Percutaneous Needle Biopsy for Small Pleural Lesions: Diagnostic Yield and Impact of CT and Ultrasound Characteristics ⓘ BACKGROUND. Ultrasound (US)-guided percutaneous pleural needle biopsy (PCPNB) is widely used to evaluate pleural lesions, although its diagnostic accuracy is variable. OBJECTIVE. The purpose of this study is to assess the diagnostic yield of US-guided PCPNB for small (<= 2 cm) pleural lesions and the impact of CT and US morphologic and technical factors. METHODS. A total of 103 patients (73 men and 30 women; mean [+/- SD] age, 68.0 +/- 13.3 years) who underwent US-guided PCPNB of a small pleural lesion performed by a single experienced operator from July 2013 to December 2019 were retrospectively analyzed. Final diagnosis was established via histopathologic results, including findings from repeat US-guided and CT-guided biopsies as well as imaging and clinical follow-up. Pleural morphology and thickness were assessed on CT and US, and needle pathway length throughout the pleura was measured on US. Accuracy, sensitivity, specificity, PPV, and NPV were calculated. The association of diagnostic yield with imaging and technical factors was evaluated. ROC curve analysis was used to determine the optimal CT pleural thickness cutoff value. Multivariable logistic regression was performed to identify independent predictors of diagnostic yield. RESULTS. The diagnostic accuracy, sensitivity, specificity, PPV, and NPV of US-guided PCPNB were 85.4%, 84.8%, 100.0%, 100.0%, and 21.1%, respectively. Diagnostic, compared with nondiagnostic, procedures more commonly (p = .002) revealed nodular morphology on CT (96.4% vs 3.6%) and US (97.3% vs 2.7%,), greater pleural thickness on CT (7.5 vs 3.2 mm) and US (7.4 vs 3.0 mm), and a greater needle pathway length (11.0 vs 6.1 mm). The optimal cutoff value for pleural thickness on CT was 4.5 mm. Diagnostic yield was 96.4% for nodular lesions, 95.0% for diffuse lesions that had a thickness of 4.5 mm or greater on CT, 55.6% for diffuse lesions that had a thickness less than 4.5 mm on CT, and 100% for diffuse lesions on CT that had nodular morphology on US. Nodular morphology on US (p = .002) and needle pathway length (p = .04) were independent predictors of diagnostic yield. CONCLUSION. US-guided PCPNB has excellent diagnostic accuracy for small pleural lesions; imaging characteristics influence this accuracy. CLINICAL IMPACT. US-guided PCPNB is highly likely diagnostic for small pleural lesions with nodular morphology on either CT or US or with a pleural thickness of 4.5 mm or greater. ⓘ Park, Jongmin; Park, Byunggeon; Lim, Jae-Kwang; Shin, Kyung Min; Lee, Jaehee; Kim, Chang Ho; Seo, Hyewon; Lee, Yong Hoon; Heo, Jun; Do, Young Woo ⓘ Kyungpook Natl Univ, Sch Med, Dept Radiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Daegu, South Korea ⓘ Lee, Yeoun Joo/AGP-1813-2022; Lee, Jaehee/S-1697-2018; Lee, Yoojin/AAB-9799-2022 ⓘ 57216463879; 57211532915; 55515341400; 7402410737; 13805476000; 7409873555; 55612130200; 57199022948; 36448170600; 57189600352 ⓘ limjk@knu.ac.kr; ⓘ AMERICAN JOURNAL OF ROENTGENOLOGY ⓘ AM J ROENTGENOL ⓘ 0361-803X 1546-3141 217 3 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ⓘ 2021 6.582 16.5 2.03 2025-07-30 ⓘ 17 19 CT pleural morphology; percutaneous needle biopsy; ultrasound-guided pleural biopsy ⓘ COMPUTED-TOMOGRAPHY CT; ASPIRATION BIOPSY; PERIPHERAL LUNG; ACCURACY; COMPLICATIONS; THORACOSCOPY; ABRAMS; US ⓘ CT pleural morphology; Percutaneous needle biopsy; Ultrasound-guided pleural biopsy ⓘ Aged; Female; Humans; Image-Guided Biopsy; Male; Pleura; Pleural Neoplasms; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Tomography, X-Ray Computed; Ultrasonography, Interventional; aged; article; controlled study; CT guided biopsy; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; female; follow up; human; major clinical study; male; needle biopsy; pleura biopsy; receiver operating characteristic; retrospective study; sensitivity and specificity; thickness; ultrasound; diagnostic imaging; image guided biopsy; interventional ultrasonography; pathology; pleura; pleura tumor; procedures; reproducibility; x-ray computed tomography ⓘ English 2021 2021-09 10.2214/ajr.20.24120 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Active galactic nuclei catalog from the AKARI NEP-Wide field ⓘ Context. The north ecliptic pole (NEP) field provides a unique set of panchromatic data that are well suited for active galactic nuclei (AGN) studies. The selection of AGN candidates is often based on mid-infrared (MIR) measurements. Such methods, despite their effectiveness, strongly reduce the breadth of resulting catalogs due to the MIR detection condition. Modern machine learning techniques can solve this problem by finding similar selection criteria using only optical and near-infrared (NIR) data.Aims. The aim of this study is to create a reliable AGN candidates catalog from the NEP field using a combination of optical SUBARU/HSC and NIR AKARI/IRC data and, consequently, to develop an efficient alternative for the MIR-based AKARI/IRC selection technique.Methods. We tested set of supervised machine learning algorithms for the purposes of carrying out an efficient process for AGN selection. The best models were compiled into a majority voting scheme, which used the most popular classification results to produce the final AGN catalog. An additional analysis of the catalog properties was performed as a spectral energy distribution fitting via the CIGALE software.Results. The obtained catalog of 465 AGN candidates (out of 33 119 objects) is characterized by 73% purity and 64% completeness. This new classification demonstrates a suitable consistency with the MIR-based selection. Moreover, 76% of the obtained catalog can be found solely using the new method due to the lack of MIR detection for most of the new AGN candidates. The training data, codes, and final catalog are available via the github repository. The final catalog of AGN candidates is also available via the CDS service.Conclusions. The new selection methods presented in this paper are proven to be a better alternative for the MIR color AGN selection. Machine learning techniques not only show similar effectiveness, but also involve less demanding optical and NIR observations, substantially increasing the extent of available data samples. ⓘ Poliszczuk, Artem; Pollo, Agnieszka; Malek, Katarzyna; Durkalec, Anna; Pearson, William J.; Goto, Tomotsugu; Kim, Seong Jin; Malkan, Matthew; Oi, Nagisa; Ho, Simon C. -C.; Shim, Hyunjin; Pearson, Chris; Hwang, Ho Seong; Toba, Yoshiki; Kim, Eunbin ⓘ Natl Ctr Nucl Res, Pasteura 7, PL-093 Warsaw, Poland; Jagiellonian Univ, Astron Observ, Ul Orla 171, PL-244 Krakow, Poland; Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France; Natl Tsing Hua Univ, Inst Astron, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; UCLA, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA; Tokyo Univ Sci, 1-3 Shinjuku, Tokyo 8601, Japan; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41566, South Korea; RAL Space, Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; Open Univ, Sch Phys Sci, Milton Keynes MK7 6AA, Bucks, England; Univ Oxford, Oxford Astrophys, Keble Rd, Oxford OX1 3RH, England; Seoul Natl Univ, Dept Phys & Astron, Astron Program, 1 Gwanak Ro, Seoul 08826, South Korea; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 8502, Japan; Acad Sinica Inst Astron & Astrophys, 11F Astron Math Bldg, NTU,1,Sect 4 Roosvel Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 8577, Japan; Korea Astron & Space Sci Inst KASI, 776 Daedeok Daero, Daejeon 34055, South Korea ⓘ Malkan, Matthew/IWM-5356-2023; Durkalec, Anna/G-3022-2015; Shim, Hyunjin/LZI-7486-2025; HWANG, Ho/AAS-6010-2020; MAŁEK, KATARZYNA/A-1254-2012 ⓘ 57192100278; 56234075800; 57226393412; 56331194100; 57195032075; 57151800100; 57226401337; 7006872661; 23968436800; 57216812477; 14061137700; 55531949600; 57207581761; 37068332400; 55202031200 ⓘ artem.poliszczuk@ncbj.gov.pl; ⓘ ASTRONOMY & ASTROPHYSICS ⓘ ASTRON ASTROPHYS ⓘ 0004-6361 1432-0746 651 SCIE ASTRONOMY & ASTROPHYSICS ⓘ 2021 6.24 16.7 0.21 2025-07-30 ⓘ 5 4 infrared: galaxies; galaxies: active; catalogs; techniques: photometric; methods: data analysis ⓘ DIGITAL-SKY-SURVEY; EFFICIENT PHOTOMETRIC SELECTION; ECLIPTIC POLE SURVEY; HOST GALAXIES; X-RAY; DUST ATTENUATION; INFRARED SOURCES; AGN CANDIDATES; OPTICAL SURVEY; UNIFIED MODEL ⓘ Catalogs; Galaxies: active; Infrared: galaxies; Methods: data analysis; Techniques: photometric ⓘ Galaxies; Infrared devices; Learning algorithms; Supervised learning; Active galactic nuclei; Classification results; Efficient process; Machine learning techniques; Selection criteria; Selection techniques; Spectral energy distribution; Supervised machine learning; Learning systems ⓘ English 2021 2021-07-27 10.1051/0004-6361/202040219 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Aquaporin water channels as regulators of cell-cell adhesion proteins ⓘ Aquaporin (AQP) water channels facilitate passive transport of water across cellular membranes following an osmotic gradient. AQPs are expressed in a multitude of epithelia, endothelia, and other cell types where they play important roles in physiology, especially in the regulation of body water homeostasis, skin hydration, and fat metabolism. AQP dysregulation is associated with many pathophysiological conditions, including nephrogenic diabetes insipidus, chronic kidney disease, and congestive heart failure. Moreover, AQPs have emerged as major players in a multitude of cancers where high expression correlates with metastasis and poor prognosis. Besides water transport, AQPs have been shown to be involved in cellular signaling, cell migration, cell proliferation, and regulation of junctional proteins involved in cell-cell adhesion; all cellular processes which are dysregulated in cancer. This review focuses on AQPs as regulators of junctional proteins involved in cell-cell adhesion. ⓘ Edamana, Sarannya; Login, Frederic H.; Yamada, Soichiro; Kwon, Tae-Hwan; Nejsum, Lene N. ⓘ Aarhus Univ, Dept Clin Med, Aarhus, Denmark; Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Taegu, South Korea ⓘ ; Kwon, Tae-Hwan/ABA-1981-2020; Yamada, Soichiro/B-7360-2019 ⓘ 57223294782; 15755818700; 9639869200; 7202206089; 57203420013 ⓘ nejsum@clin.au.dk; ⓘ AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY ⓘ AM J PHYSIOL-CELL PH ⓘ 0363-6143 1522-1563 320 5 SCIE CELL BIOLOGY;PHYSIOLOGY ⓘ 2021 5.282 16.7 0.82 2025-07-30 ⓘ 28 29 AQP; cancer; cell-cell adhesion; E-cadherin; b-catenin ⓘ EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; EXPRESSION; MIGRATION; INVASION; AQP1; PROLIFERATION; CONTRIBUTES; METASTASIS ⓘ AQP; Cancer; Cell-cell adhesion; E-cadherin; β -catenin ⓘ Animals; Aquaporins; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Humans; Neoplasms; Organism Hydration Status; Protein Conformation; Signal Transduction; Structure-Activity Relationship; Water; Water-Electrolyte Balance; aquaporin; aquaporin 1; aquaporin 3; aquaporin 4; aquaporin 5; aquaporin 8; aquaporin 9; cell adhesion molecule; aquaporin; cell adhesion molecule; water; cell adhesion; human; nonhuman; priority journal; protein expression; protein function; protein localization; protein structure; protein transport; Review; animal; cell motion; cell proliferation; chemistry; electrolyte balance; epithelial mesenchymal transition; hydration status; metabolism; neoplasm; pathology; protein conformation; signal transduction; structure activity relation ⓘ English 2021 2021-05 10.1152/ajpcell.00608.2020 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Galaxies within galaxies in the TIMER survey: stellar populations of inner bars are scaled replicas of main bars ⓘ Inner bars are frequent structures in the local Universe and thought to substantially influence the nuclear regions of disc galaxies. In this study we explore the structure and dynamics of inner bars by deriving maps and radial profiles of their mean stellar population content and comparing them to previous findings in the context of main bars. To this end, we exploit observations obtained with the integral-field spectrograph MUSE of three double-barred galaxies in the TIMER sample. The results indicate that inner bars can be clearly distinguished based on their stellar population properties alone. More precisely, inner bars show significantly elevated metallicities and depleted [alpha /Fe] abundances. Although they exhibit slightly younger stellar ages compared to the nuclear disc, the typical age differences are small, except at their outer ends. These ends of the inner bars are clearly younger compared to their inner parts, an effect known from main bars as orbital age separation. In particular, the youngest stars (i.e. those with the lowest radial velocity dispersion) seem to occupy the most elongated orbits along the (inner) bar major axis. We speculate that these distinct ends of bars could be connected to the morphological feature of ansae. Radial profiles of metallicity and [alpha /Fe] enhancements are flat along the inner bar major axis, but show significantly steeper slopes along the minor axis. This radial mixing in the inner bar is also known from main bars and indicates that inner bars significantly affect the radial distribution of stars. In summary, based on maps and radial profiles of the mean stellar population content and in line with previous TIMER results, inner bars appear to be scaled down versions of the main bars seen in galaxies. This suggests the picture of a 'galaxy within a galaxy', with inner bars in nuclear discs being dynamically equivalent to main bars in main galaxy discs. ⓘ Bittner, Adrian; de Lorenzo-Caceres, Adriana; Gadotti, Dimitri A.; Sanchez-Blazquez, Patricia; Neumann, Justus; Coelho, Paula; Falcon-Barroso, Jesus; Fragkoudi, Francesca; Kim, Taehyun; Martin-Navarro, Ignacio; Mendez-Abreu, Jairo; Perez, Isabel; Querejeta, Miguel; van de Ven, Glenn ⓘ European Southern Observ, Karl Schwarzschild Str 2, D-85748 Munich, Germany; Ludwig Maximilians Univ Munchen, Prof Huber Pl 2, D-80539 Munich, Germany; Inst Astrofis Canarias, Calle Via Lactea S-N, Tenerife, Spain; Univ La Laguna, Dept Astrofis, Tenerife 38200, Spain; Univ Complutense Madrid, Dept Fis Tierra & Astrofis, Madrid 28040, Spain; Univ Complutense Madrid, Inst Fis Particulas & Cosmos, Madrid 28040, Spain; Univ Portsmouth, Inst Cosmol & Gravitat, Burnaby Rd, Portsmouth PO1 3FX, Hants, England; Univ Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, R Matao 1226, BR-05508090 Sao Paulo, Brazil; Max Planck Inst Astrophys, Karl Schwarzschild Str 1, D-85748 Munich, Germany; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 702701, South Korea; Univ Granada, Fac Ciencias, Dept Fis Teor & Cosmos, Granada 18071, Spain; Univ Granada, Inst Univ Carlos I Fis Teor & Computat, Granada 18071, Spain; Observ Astron Nacl, C Alfonso 11 3, Madrid 28014, Spain; Univ Vienna, Dept Astrophys, Turkenschanzstr 17, A-1180 Vienna, Austria ⓘ ; Martin-Navarro, Ignacio/F-5882-2016; Sanchez-Blazquez, Patricia/IYS-6088-2023; de Lorenzo-Cáceres, Adriana/AAA-6412-2020; van de Ven, Glenn/R-5189-2019; Perez, Isabel/AAF-9177-2019; Coelho, Paula/B-1592-2015; Querejeta, Miguel/KVY-3638-2024; Falcon-Barroso, Jesus/AAD-9660-2019 ⓘ 57203535764; 23088009300; 55887354100; 16319840900; 56514665700; 23011441600; 6602632408; 55062198600; 57050549000; 55498121400; 23051261000; 57211263715; 35424450700; 18038742400 ⓘ adrian.bittner@eso.org; ⓘ ASTRONOMY & ASTROPHYSICS ⓘ ASTRON ASTROPHYS ⓘ 0004-6361 1432-0746 646 SCIE ASTRONOMY & ASTROPHYSICS ⓘ 2021 6.24 16.7 0.77 2025-07-30 ⓘ 16 16 galaxies: structure; galaxies: spiral; galaxies: stellar content; galaxies: groups: individual: NGC 1291; galaxies: individual: NGC 1433; galaxies: individual: NGC 5850 ⓘ RESOLUTION GALACTIC SPECTRA; EMISSION-LINE KINEMATICS; DOUBLE-BARRED GALAXIES; STAR-FORMATION; SAURON PROJECT; EVOLUTION DATABASE; SECULAR EVOLUTION; ABSORPTION; PHOTOMETRY; MODELS ⓘ Galaxies: groups: individual: NGC 1291; Galaxies: individual: NGC 1433; Galaxies: individual: NGC 5850; Galaxies: spiral; Galaxies: stellar content; Galaxies: structure ⓘ Stars; Timing circuits; Integral field spectrograph; Morphological features; Radial distributions; Radial profiles; Radial velocity; Scaled-down versions; Stellar populations; Structure and dynamics; Galaxies ⓘ English 2021 2021-02-04 10.1051/0004-6361/202039505 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Impact of tenofovir alafenamide vs. entecavir on hepatocellular carcinoma risk in patients with chronic hepatitis B ⓘ Background and aims Whether entecavir (ETV) or tenofovir alafenamide (TAF) is better at preventing hepatocellular carcinoma (HCC) development among patients with chronic hepatitis B (CHB) remains unclear. The present study was conducted to explore the ability of these two antivirals to prevent HCC. Methods From 2012 to 2019, treatment-naive CHB patients undergoing ETV or TAF therapy were recruited at three academic teaching hospitals. The TAF group comprised patients starting TAF as first-line antiviral and those switching antivirals from tenofovir disoproxil fumarate to TAF. Patients with decompensated cirrhosis or HCC at enrollment were excluded from the analysis. Cumulative probabilities of HCC were assessed using the Kaplan-Meier method. Results In total, 1810 patients (1525 and 285 in ETV and TAF groups, respectively) were recruited. The annual HCC incidence was statistically not different between the ETV and TAF groups (1.67 vs. 1.19 per 100 person-years, respectively) with an adjusted hazard ratio (HR) of 0.681 (p = 0.255), as determined by multivariate analysis. Male, hypertension, liver cirrhosis, FIB-4 index, and albumin were independent prognostic factors for HCC development. Propensity score-matched and inverse probability of treatment weighting analyses yielded similar results, with non-statistically different HCC incidence between the ETV and TAF groups (1.07 vs. 1.19 per 100 person-years (HR = 0.973; p = 0.953) and 1.67 vs. 1.89 per 100 person-years, respectively (HR = 0.949; p = 0.743). Conclusions These findings suggest that ETV- and TAF-treated CHB patients have similar risk of developing HCC. Further studies with the larger sample size and longer follow-up are needed to validate these results. ⓘ Lee, Hye Won; Cho, Young Youn; Lee, Hyein; Lee, Jae Seung; Kim, Seung Up; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Kim, Beom Kyung; Park, Soo Young ⓘ Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea; Yonsei Univ Hlth Syst, Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea ⓘ ; Lee, Hye/D-9081-2016; SANG-HOON, AHN/AAV-2600-2020; Kim, Dong/F-4608-2014; Kim, Sung-Won/J-5409-2012; Kim, Sun/L-4239-2013; Park, Jun/H-7127-2019; LEE, JAE SEUNG/KHT-9575-2024; Ahn, Sang Hoon/AFM-2603-2022 ⓘ 57200110315; 55850994200; 57222812336; 57204060462; 54933821200; 47861376300; 56119929100; 7401989551; 35302925200; 57191674344 ⓘ beomkkim@yuhs.ac;psyoung0419@gmail.com; ⓘ HEPATOLOGY INTERNATIONAL ⓘ HEPATOL INT ⓘ 1936-0533 1936-0541 15 5 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2021 9.046 16.7 1.06 2025-07-30 ⓘ 22 22 Chronic hepatitis B; Entecavir; Hepatocellular carcinoma; Risk factor; Tenofovir alafenamide ⓘ DISOPROXIL FUMARATE; DOUBLE-BLIND; VIRUS INFECTION; CIRRHOSIS; PHASE-3; DNA ⓘ Chronic hepatitis B; Entecavir; Hepatocellular carcinoma; Risk factor; Tenofovir alafenamide ⓘ Alanine; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Retrospective Studies; Tenofovir; Treatment Outcome; albumin; entecavir; tenofovir alafenamide; tenofovir disoproxil; alanine; antivirus agent; entecavir; guanine; tenofovir; tenofovir alafenamide; adult; albumin blood level; Article; cancer prevention; cancer prognosis; cancer risk; carcinogenesis; chronic hepatitis B; cohort analysis; controlled study; drug safety; drug substitution; drug withdrawal; female; FIB 4 index; human; human tissue; hypertension; incidence; liver cell carcinoma; liver cirrhosis; major clinical study; male; middle aged; scoring system; sex ratio; teaching hospital; complication; liver cell carcinoma; liver tumor; retrospective study; treatment outcome ⓘ English 2021 2021-10 10.1007/s12072-021-10234-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation ⓘ Leucyl-tRNA synthetase 1 (LARS1) mediates activation of leucine-dependent mechanistic target of rapamycin complex 1 (mTORC1) as well as ligation of leucine to its cognate tRNAs, yet its mechanism of leucine sensing is poorly understood. Here we describe leucine binding-induced conformational changes of LARS1. We determine different crystal structures of LARS1 complexed with leucine, ATP, and a reaction intermediate analog, leucyl-sulfamoyl-adenylate (Leu-AMS), and find two distinct functional states of LARS1 for mTORC1 activation. Upon leucine binding to the synthetic site, H251 and R517 in the connective polypeptide and (FPYPY54)-F-50 in the catalytic domain change the hydrogen bond network, leading to conformational change in the C-terminal domain, correlating with RagD association. Leucine binding to LARS1 is increased in the presence of ATP, further augmenting leucine-dependent interaction of LARS1 and RagD. Thus, this work unveils the structural basis for leucine-dependent long-range communication between the catalytic and RagD-binding domains of LARS1 for mTORC1 activation. ⓘ Kim, Sulhee; Yoon, Ina; Son, Jonghyeon; Park, Junga; Kim, Kibum; Lee, Ji-Ho; Park, Sam-Yong; Kang, Beom Sik; Han, Jung Min; Hwang, Kwang Yeon; Kim, Sunghoon ⓘ Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Pharm, Med Bioconvergence Res Ctr,Inst Artificial Intell, Incheon 21983, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Incheon 21983, South Korea; Yonsei Univ, Coll Pharm, Yonsei Inst Pharmaceut Sci, Incheon 21983, South Korea; Yonsei Univ, Grad Sch, Interdisciplinary Program Integrated OMICS Biomed, Seoul 03722, South Korea; Yokohama City Univ, Grad Sch Med Life Sci, Drug Design Lab, Yokohama, Kanagawa 2300045, Japan; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, KNU Creat BioRes Grp, Daegu 41566, South Korea ⓘ Kim, Sulhee/HLW-9057-2023; Han, Jung Min/ISV-2843-2023; Kim, Sunghoon/AAE-8314-2020 ⓘ 57102883900; 56448180300; 55881098100; 57214147427; 57209218776; 57223159387; 7501826573; 35082104200; 7406439693; 7402426879; 7601582514 ⓘ chahong@korea.ac.kr;sunghoonkim@yonsei.ac.kr; ⓘ CELL REPORTS ⓘ CELL REP ⓘ 2211-1247 35 4 SCIE CELL BIOLOGY ⓘ 2021 9.995 16.7 1.19 2025-07-30 ⓘ 31 32 ⓘ PROOFREADING FUNCTIONAL CYCLE; AMINO-ACID LEVELS; CRYSTAL-STRUCTURE; RAG GTPASES; TRANSPORTER SLC38A9; MAMMALIAN TARGET; TUMOR-SUPPRESSOR; COMPLEX; METABOLISM; AMINOACYLATION ⓘ conformational change; leucine sensing; leucyl-tRNA synthetase 1; mechanistic target of rapamycin complex 1; X-ray crystallography ⓘ Humans; Leucine; Leucine-tRNA Ligase; Mechanistic Target of Rapamycin Complex 1; Models, Molecular; Signal Transduction; adenosine triphosphate; amino acid derivative; amino acid transfer RNA ligase; arginine; binding protein; histidine; leucine; leucine transfer RNA ligase 1; leucylsulfamoyladenylate; mammalian target of rapamycin complex 1; protein RagD; unclassified drug; leucine; leucine transfer RNA ligase; mammalian target of rapamycin complex 1; Article; carboxy terminal sequence; complex formation; conformational transition; controlled study; crystal structure; embryo; enzyme active site; Escherichia coli; HEK293T cell line; human; human cell; hydrogen bond; nonhuman; protein protein interaction; metabolism; molecular model; signal transduction ⓘ English 2021 2021-04-27 10.1016/j.celrep.2021.109031 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Novel glaucoma model in rats using photo-crosslinked azidobenzoic acid-modified chitosan ⓘ An experimental model of pressure-induced optic nerve damage promises to greatly expand understanding of the cellular events leading to retinal ganglion cell (RGC) death and of how they are influenced by intraocular pressure (IOP) and other risk factors associated with glaucoma. In this work, we propose a novel strategy employing photo-crosslinkable azidobenzoic acid-modified chitosan (Az-CH) for long-term, persistent elevation of IOP. For this purpose, a solution of Az-CH was injected into the anterior chamber of experimental rat eyes, which were subsequently irradiated with ultraviolet (UV) light to form an Az-CH gel that hindered aqueous outflow and effected prolonged IOP elevation thereby. The control eyes were treated as follows: (1) intracameral injection of Az-CH without UV irradiation, (2) intracameral injection of saline solution without UV irradiation or (3) no injection with UV irradiation. A significant IOP increase was observed in the experimental eyes, which was continuously higher for the whole testing period of 12 weeks after one-time treatment with Az-CH injection and UV irradiation. Also, a more significant loss of RGCs, one of the major features of glaucoma, was observed in experimental eyes than in the control eyes. Therefore, the strategy presented herein can be a novel experimental model to study the mechanism of RGC damage by elevated IOP over the course of a prolonged period. ⓘ Kim, Young Kook; Kim, Se-Na; Min, Chang Hee; Park, Min; Kim, Dai Woo; Ha, Ahnul; Kim, Yu Jeong; Choy, Young Bin; Park, Ki Ho ⓘ Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul, South Korea; Seoul Natl Univ, Inst Med & Biol Engn, Med Res Ctr, Seoul, South Korea; Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Jeju Natl Univ Hosp, Dept Ophthalmol, Jeju Si, South Korea; Jeju Natl Univ, Sch Med, Dept Ophthalmol, Jeju Si, South Korea; Seoul Natl Univ, Coll Med, Dept Biomed Engn, 101 Daehak Ro, Seoul 03080, South Korea ⓘ ; Cho, Young-Seok/J-5670-2012; Kim, Young-Kook/AAE-8306-2020; Park, Ki-Ho/MYQ-9501-2025; Ha, Ahnul/ABD-1589-2020; Kim, You Sun/B-2881-2015 ⓘ 55908959500; 56765084300; 57203681572; 7404490118; 57095192800; 57189002120; 7410211468; 7004920265; 56276582800 ⓘ ybchoy@snu.ac.kr;kihopark@snu.ac.kr; ⓘ MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS ⓘ MAT SCI ENG C-MATER ⓘ 0928-4931 1873-0191 125 SCIE MATERIALS SCIENCE, BIOMATERIALS ⓘ 2021 8.457 16.7 0.23 2025-07-30 ⓘ 2 2 Glaucoma; Intraocular pressure; Chitosan; Azidobenzoic acid; UV irradiation ⓘ TRABECULAR MESHWORK; PHOTOCROSSLINKABLE CHITOSAN; INTRAOCULAR-PRESSURE; OCULAR HYPERTENSION; DAMAGE; PHOTOCOAGULATION; HYDROGELS; OCCLUSION; DEATH ⓘ Azidobenzoic acid; Chitosan; Glaucoma; Intraocular pressure; UV irradiation ⓘ Animals; Chitosan; Disease Models, Animal; Glaucoma; Intraocular Pressure; Rats; Retinal Ganglion Cells; Eye protection; Irradiation; Ophthalmology; chitosan; Azidobenzoic acid; Cellular events; Crosslinked; Experimental models; Intraocular pressure; Modified chitosan; Nerve damage; Optic nerve; Retinal ganglion cells; Ultraviolet irradiations; animal; disease model; glaucoma; intraocular pressure; rat; retina ganglion cell; Chitosan ⓘ English 2021 2021-06 10.1016/j.msec.2021.112112 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Pathological angiogenesis and inflammation in tissues ⓘ The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular-organ interaction is a key mechanism and a concept that enables an understanding of all biological phenomena and normal physiology that is essential for human survival under pathological conditions. Recently, vascular endothelial cells have been classified as a type of innate immune cells that are dependent on the pathological situations. Moreover, inflammatory cytokines and signaling regulators activated upon exposure to infection or various stresses play crucial roles in the pathological function of parenchymal cells, peripheral immune cells, stromal cells, and cancer cells in tissues. Therefore, vascular-organ interactions as a vascular microenvironment or tissue microenvironment under physiological and pathological conditions are gaining popularity as an interesting research topic. Here, we review vascular contribution as a major factor in microenvironment homeostasis in the pathogenesis of normal as well as cancerous tissues. Furthermore, we suggest that the normalization strategy of pathological angiogenesis could be a promising therapeutic target for various diseases, including cancer. ⓘ Jeong, Ji-Hak; Ojha, Uttam; Lee, You Mie ⓘ Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, MRC, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu 41566, South Korea ⓘ Lee, Kyung-Soo/C-9016-2011 ⓘ 55913671500; 57192203609; 8230508600 ⓘ lym@knu.ac.kr; ⓘ ARCHIVES OF PHARMACAL RESEARCH ⓘ ARCH PHARM RES ⓘ 0253-6269 1976-3786 44 1 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY ⓘ 2021 6.01 16.7 3.17 2025-07-30 ⓘ 117 112 Vascular endothelial cells; Angiogenesis; Vascular abnormality; Inflammation; Vascular normalization; Anti-angiogenic therapy; Organ diseases ⓘ ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; METASTATIC COLORECTAL-CANCER; LYMPHATIC METASTASIS; MAMMALIAN TARGET; DRUG-DELIVERY; VEGF; CELLS; LIVER; NORMALIZATION ⓘ Angiogenesis; Anti-angiogenic therapy; Inflammation; Organ diseases; Vascular abnormality; Vascular endothelial cells; Vascular normalization ⓘ Angiogenesis Inhibitors; Animals; Cytokines; Endothelial Cells; Endothelium, Vascular; Humans; Inflammation; Inflammation Mediators; Neoplasms; Neovascularization, Pathologic; Signal Transduction; Tumor Microenvironment; 2 methoxyestradiol; 4 [bis(2 chloroethyl)oxidoamino]phenylalanine; antineoplastic agent; bevacizumab; everolimus; ezn 2968; fibroblast growth factor 2; interleukin 1beta; interleukin 6; monoclonal antibody DC101; ramucirumab; topotecan; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin receptor; angiogenesis inhibitor; autacoid; cytokine; brain blood vessel; breast cancer; cancer tissue; carcinogenesis; colorectal cancer; endothelium cell; esophagus carcinoma; gastroesophgeal junction carcinoma; human; immunocompetent cell; inflammation; liver cell carcinoma; liver circulation; lung blood vessel; lymphoma; metastatic colorectal cancer; molecularly targeted therapy; nervous system inflammation; non small cell lung cancer; nonhuman; pathophysiology; Review; solid malignant neoplasm; stomach cancer; tumor hypoxia; tumor-associated macrophage; VEGF signaling; animal; drug effect; immunology; inflammation; metabolism; neoplasm; neovascularization (pathology); pathology; signal transduction; tumor microenvironment; vascular endothelium; vascularization ⓘ English 2021 2021-01 10.1007/s12272-020-01287-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity ⓘ The maintenance of lysosomal integrity is essential for lysosome function and cell fate. Damaged lysosomes are degraded by lysosomal autophagy, lysophagy. The mechanism underlying lysophagy remains largely unknown; this study aimed to contribute to the understanding of this topic. A cell-based screening system was used to identify novel lysophagy modulators. Triamterene (6-phenylpteridine-2,4,7-triamine) was identified as one of the most potent lysophagy inducers from the screening process. We found that triamterene causes lysosomal rupture without affecting other cellular organelles and increases autophagy flux in HepG2 cells. Damaged lysosomes in triamterene-treated cells were removed by autophagy-mediated pathway, which was inhibited by depletion of the autophagy regulator, ATG5 or SQSTM1. In addition, treatment of triamterene decreased the integrity of lysosome and cell viability, which were rescued by removing the triamterene treatment in HepG2 cells. Hence, our data suggest that triamterene is a novel lysophagy inducer through the disruption of lysosomal integrity. ⓘ Park, Na Yeon; Jo, Doo Sin; Kim, Yong Hwan; Bae, Ji-Eun; Kim, Joon Bum; Park, Hyun Jun; Choi, Ji Yeon; Lee, Ha Jung; Chang, Jeong Ho; Bunch, Heeyoun; Jeon, Hong Bae; Jung, Yong-Keun; Cho, Dong-Hyung ⓘ Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, 8 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; ENCell Co Ltd, Stem Cell Inst, Seoul 06072, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea ⓘ Kim, Joon/ADP-8066-2022; KIM, SUNG/ADF-8559-2022; Choi, Hye Rin/JDV-9065-2023; Bunch, Heeyoun/JAX-3215-2023 ⓘ 57190609826; 56335489800; 57204676401; 57190605352; 57190611030; 57209409221; 57219085234; 57221856423; 57203598905; 56336812200; 59452113500; 35358575000; 35093684400 ⓘ dhcho@knu.ac.kr; ⓘ ARCHIVES OF PHARMACAL RESEARCH ⓘ ARCH PHARM RES ⓘ 0253-6269 1976-3786 44 6 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY ⓘ 2021 6.01 16.7 0.25 2025-07-30 ⓘ 5 5 Triamterene; Lysophagy; Lysosomal integrity; Autophagy; LLOMe; HepG2 cells ⓘ MEMBRANE PERMEABILIZATION; DAMAGED LYSOSOMES; CLEARANCE; CELLS; TFEB; ACIDIFICATION; GALECTIN-3; VESICLES; DRUG ⓘ Autophagy; HepG2 cells; LLOMe; Lysophagy; Lysosomal integrity; Triamterene ⓘ Autophagy; Cell Survival; Epithelial Sodium Channel Blockers; HeLa Cells; Hep G2 Cells; Humans; Lysosomes; Triamterene; autophagy related protein 5; glucose regulated protein 78; leucylleucine methyl ester; polyvinylidene fluoride; reactive oxygen metabolite; short hairpin RNA; small interfering RNA; triamterene; epithelial sodium channel blocking agent; triamterene; apoptosis; Article; autophagosome; autophagy (cellular); cell fate; cell viability; controlled study; cytotoxicity; degradation; disease exacerbation; endocytosis; endoplasmic reticulum; endoplasmic reticulum stress; enzymatic degradation; fluorescence microscopy; Hep-G2 cell line; human; human cell; immunoblotting; immunoprecipitation; in vitro study; lysosome; mitochondrial membrane potential; MTT assay; protein expression; transmission electron microscopy; ubiquitination; Western blotting; xenophagy; autophagy; cell survival; drug effect; HeLa cell line; lysosome; metabolism; physiology ⓘ English 2021 2021-06 10.1007/s12272-021-01335-5 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Win-Stay-Lose-Shift as a self-confirming equilibrium in the iterated Prisoner's Dilemma ⓘ Evolutionary game theory assumes that players replicate a highly scored player's strategy through genetic inheritance. However, when learning occurs culturally, it is often difficult to recognize someone's strategy just by observing the behaviour. In this work, we consider players with memory-one stochastic strategies in the iterated Prisoner's Dilemma, with an assumption that they cannot directly access each other's strategy but only observe the actual moves for a certain number of rounds. Based on the observation, the observer has to infer the resident strategy in a Bayesian way and chooses his or her own strategy accordingly. By examining the best-response relations, we argue that players can escape from full defection into a cooperative equilibrium supported by Win-Stay-Lose-Shift in a self-confirming manner, provided that the cost of cooperation is low and the observational learning supplies sufficiently large uncertainty. ⓘ Kim, Minjae; Choi, Jung-Kyoo; Baek, Seung Ki ⓘ Pukyong Natl Univ, Dept Phys, Busan 48513, South Korea; Kyungpook Natl Univ, Dept Econ, Daegu 41566, South Korea ⓘ Baek, Seung/B-7835-2014; Baek, Seung Ki/B-7835-2014 ⓘ 57192081999; 27171100800; 7102686285 ⓘ seungki@pknu.ac.kr; ⓘ PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ⓘ P ROY SOC B-BIOL SCI ⓘ 0962-8452 1471-2954 288 1953 SCIE BIOLOGY;ECOLOGY;EVOLUTIONARY BIOLOGY ⓘ 2021 5.531 16.7 0.56 2025-07-30 ⓘ 7 7 evolution of cooperation; reciprocity; Bayesian inference; Win-Stay-Lose-Shift; observational learning ⓘ TIT-FOR-TAT; CONVERGENCE; STRATEGIES; GAMES ⓘ Bayesian inference; evolution of cooperation; observational learning; reciprocity; Win-Stay-Lose-Shift ⓘ Bayes Theorem; Biological Evolution; Cooperative Behavior; Game Theory; Prisoner Dilemma; equilibrium; research work; Bayes theorem; cooperation; evolution; game; prisoner dilemma ⓘ English 2021 2021-06-30 10.1098/rspb.2021.1021 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Animal feed formulation: Rapid and non-destructive measurement of components from waste by-products ⓘ The major cost (60?80%) of animal production is attributed to feed but most growers are yet to accept and adopt alternative materials like by-products due to their vast variations in nutrient components. Feed and animal production methods are currently considered as unsustainable -with environmental issues related to by-products disposal. Rapid and non-destructive models for quantifying sugars, organic acids, amino acids and other nutrients in alternative materials and a model for precision animal feed production were developed. Consequently, we investigated the nutrient components of by-products using line-scan hyperspectral imaging (HSI) technique. Hyperspectral images of by-products were acquired in the spectral range of 1000?2500 nm. The spectral data were extracted and preprocessed to develop a prediction model using partial least square regression (PLSR) analysis. The PLSR models developed resulted in the following acceptable prediction accuracies (R2p); sugars (0.76?0.94), organic acids (0.72?0.75), amino acids (0.55?0.84), and other nutrients content (0.69?0.96). The root means square error of predictions (RMSEP) obtained were sugars (0.076?0.524 mg/mL), organic acids (0.360?0.626 mg/ mL), amino acids (0.007?0.052 mg/mL), and other nutrients content (0.403?1.035 %). The results obtained from the PLSR models showed reliable performance for quantifying chemical components of different by-products. Further, the generated PLSR-based chemical-mapped images facilitated the visual assessment of the chemical concentration and distribution in byproducts. Thus, based on the results, the application of HSI in combination with multivariate analysis method of PLSR in a commercial setting may be feasible. This can ultimately enable costsaving in breeding by curtailing overfeeding and post-production losses and significantly mitigate environmental issues related to by-products disposal. ⓘ Uyeh, Daniel Dooyum; Ha, Yushin; Park, Tusan ⓘ Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu, South Korea ⓘ ; Park, Tusan/C-2057-2012 ⓘ 57194449611; 57192072314; 57202780408 ⓘ yushin72@knu.ac.kr;tusan.park@knu.ac.kr; ⓘ ANIMAL FEED SCIENCE AND TECHNOLOGY ⓘ ANIM FEED SCI TECH ⓘ 0377-8401 1873-2216 274 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE ⓘ 2021 3.313 16.9 1.53 2025-07-30 ⓘ 5 10 Animal nutrition; Agricultural and industrial by-products; Hyperspectral imaging; Partial least square regression; Precision animal feed production ⓘ NEAR-INFRARED SPECTROSCOPY; MECHANICAL-PROPERTIES; ORGANIC-ACIDS; PROTEIN; QUALITY; WHEAT; NITROGEN; WINE ⓘ Agricultural and industrial by-products; Animal nutrition; Hyperspectral imaging; Partial least square regression; Precision animal feed production ⓘ ⓘ English 2021 2021-04 10.1016/j.anifeedsci.2021.114848 ⓘ 바로가기 바로가기 바로가기 바로가기
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