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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice | Limited studies reported mechanisms by which microRNAs (miRNA) are interlinked in the etiology of fructose-induced non-alcoholic fatty liver disease (NAFLD). Here, we aimed to investigate the significance of miRNAs in fructose-induced NAFLD pathogenesis through unbiased approaches. In experiment I, C57BL/6N mice were fed either water or 34% fructose for six weeks ad libitum. In experiment II, time course effects of fructose intervention were monitored using the same conditions; mice were killed at the baseline, fourth, and sixth weeks. Bioinformatic analyses for hepatic proteomics revealed that SREBP1 is the most significant upstream regulator influenced by fructose; miR-33-5p (miR-33) was identified as the key miRNA responsible for SREBP1 regulation upon fructose intake, which was validated by in vitro transfection assay. In experiment II, we confirmed that the longer mice consumed fructose, the more severe liver injury markers (e.g., serum AST) appeared. Moreover, hepatic Srebp1 mRNA expression was increased depending upon the duration of fructose consumption. Hepatic miR-33 was time-dependently decreased by fructose while serum miR-33 expression was increased; these observations indicated that miR-33 from the liver might be released upon cell damage. Finally we observed that fructose-induced ferroptosis might be a cause of liver toxicity, resulting from oxidative damage. Collectively, our findings suggest that fructose-induced oxidative damage induces ferroptosis, and miR-33 could be used as a serological biomarker of fructose-induced NAFLD. | Pan, Jeong Hoon; Cha, Hanvit; Tang, Jingsi; Lee, Seoyoon; Lee, Suk Hee; Le, Brandy; Redding, Mersady C.; Kim, Sangyub; Batish, Mona; Kong, Byungwhi C.; Lee, Jin Hyup; Kim, Jae Kyeom | Univ Arkansas, Sch Human Environm Sci, Fayetteville, AR 72701 USA; Univ Delaware, Dept Behav Hlth & Nutr, Newark, DE 19716 USA; Korea Univ, Dept Food & Biotechnol, Sejong 30019, South Korea; Univ Arkansas, Dept Anim Sci, Fayetteville, AR 72701 USA; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Penn State Univ, Dept Pharmacol, Hershey, PA 17033 USA; Univ Delaware, Dept Mol & Med Sci, Newark, DE 19716 USA; Univ Arkansas, Dept Poultry Sci, Fayetteville, AR 72701 USA | Batish, Mona/AAG-8296-2019; Kim, Jae Kyeom/AAE-8141-2022; Kim, Sangyub/AAR-1037-2021 | 57201234370; 57189372342; 57215680624; 57191828926; 35242753100; 57702392500; 57209643399; 57204539795; 23987330400; 7005061653; 36067819400; 57221817528 | bkong@uark.edu;jinhyuplee@korea.ac.kr;jkkim@udel.edu; | FOOD & FUNCTION | FOOD FUNCT | 2042-6496 | 2042-650X | 12 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;FOOD SCIENCE & TECHNOLOGY | 2021 | 6.317 | 16.3 | 1.67 | 2025-07-30 | 26 | 24 | CELL-DEATH; FERROPTOSIS; RECEPTOR; PATHOGENESIS; EXPRESSION; TRANSCRIPTION; ACCUMULATION; STEATOSIS; APOPTOSIS; GLUCOSE | Animals; Biomarkers; Diet; Female; Fructose; Gene Expression Regulation; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Sterol Regulatory Element Binding Protein 1; Biomarkers; Diseases; Mammals; Proteomics; RNA; biological marker; fructose; microRNA; Mirn33 microRNA, mouse; Srebf1 protein, mouse; sterol regulatory element binding protein 1; Bioinformatic analysis; Cell damage; Key regulators; Lipogenesis; Liver injuries; Liver toxicity; Non-alcoholic fatty liver disease; Oxidative damage; animal; blood; C57BL mouse; diet; drug effect; female; gene expression regulation; genetics; lipogenesis; liver; male; metabolism; mouse; nonalcoholic fatty liver; physiology; Fructose | English | 2021 | 2021-01-21 | 10.1039/d0fo02286a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Particulate matters removal by using cotton coated with isomeric metal-organic frameworks (MOFs): Effect of voidage of MOFs on removal | High quality of air is indispensable for our comfortable life and sustainability; however, air contamination with various substances, especially with particulate matters (PMs), is worsening in recent days. In this study, we applied three isomeric metal-organic frameworks (MOFs) such as MAF-5, MAF-6 and MAF-32 (MAF means metal-azolate framework, a sub-class of MOF), after coated on cotton, in removing PMs from air. Isomeric MOFs were applied to identify an important parameter of MOFs in PM capture/removal since those MOFs have different characteristics (even have the very same composition). It was found that removal efficiency and quality factor (QF) of MAFs/cotton linearly increased with increasing the voidage (v/v) of the investigated MAFs, suggesting the importance of voidage of MOFs in PM capture. Moreover, we could explain how MAFs with small pore (compared with the size of PMs) is effective in interaction (for capture) between PM and MAFs. Finally, the MAF-6, the best MAF among the studied MAFs, was much more efficient in PM removal than conventional or widely applied MOFs like ZIF-8 (for example, QF for PM2.5 of cotton, MAF-6/cotton and ZIF-8/cotton are 0.016, 0.060 and 0.030 Pa-1, respectively). (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | Woo, Ho Chul; Yoo, Dong Kyu; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | ; Jhung, Sung/AAO-6683-2021 | 57217234591; 57201339246; 6701659467 | sung@knu.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 95 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2021 | 6.76 | 16.4 | 0.98 | 2025-07-30 | 19 | 17 | Air filter; Isomer; MAFs; MOFs; Particulate matter; Voidage | ZEOLITIC IMIDAZOLATE FRAMEWORK-8; IN-SITU GROWTH; AIR FILTERS; FIBROUS MEMBRANES; GAS-ADSORPTION; PM2.5 CAPTURE; FIBER; FUNCTIONALIZATION; HYBRIDIZATION; SEPARATION | Air filter; Isomer; MAFs; MOFs; Particulate matter; Voidage | Cotton; Organometallics; Air contamination; High quality; Metalorganic frameworks (MOFs); Particulate Matter; PM removal; Quality factors; Removal efficiencies; Sub class; Metal-Organic Frameworks | English | 2021 | 2021-03-25 | 10.1016/j.jiec.2020.12.035 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preparation of uniformly sized interpenetrating polymer network polyelectrolyte hydrogel droplets from a solid-state liquid crystal shell | Uniformly sized interpenetrating polymer network (IPN) polyelectrolyte hydrogel droplets were produced with solid-state liquid crystal (LCsolid) shells, which had been produced by a microfluidic method. The weak polyelectrolyte hydrogel and the temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) networks were intertwined in the LCsolid shell to produce an IPN structure; the anionic poly(acrylic acid) (PAA) and cationic poly(N-[3-(dimethylamino)propyl] methacrylamide) (PDMAPMA) were utilized for the weak polyelectrolyte hydrogel networks. The anionic PNIPAM/PAA, cationic PNIPAM/PDMAPMA, and zwitterionic PAA/PDMAPMA IPN droplets were successfully produced by the LCsolid shell templates. The PNIPAM/PAA IPN droplets were applied to a Ca2+ sensor. Further, the anionic PNIPAM/PAA and cationic PNIPAM/PDMAPMA IPN droplets could adsorb the cationic methylene blue and anionic Acid Red 37 dyes, respectively, while the zwitterionic PAA/PDMAPMA IPN droplets could adsorb both dyes. This method of producing uniformly sized IPN hydrogel droplets from LCsolid shell templates is simple and does not require any sophisticated machines. (C) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | Gwon, Sojeong; Park, Sooyoung | Kyungpook Natl Univ, Sch Appl Chem Engn, Polymer Nanomat Lab, Daegu 41566, South Korea | park, soo-young/N-3170-2017 | 57219337908; 57194041850 | psy@knu.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 99 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2021 | 6.76 | 16.4 | 0.84 | 2025-07-30 | 13 | 13 | Interpenetrating polymer network; Hydrogel; Polyelectrolyte; Microfluidics; Droplet; Template | FABRICATION; MEMBRANES; RELEASE | Droplet; Hydrogel; Interpenetrating polymer network; Microfluidics; Polyelectrolyte; Template | Acrylic monomers; Amides; Azo dyes; Drops; Hydrogels; Liquid crystals; Microfluidics; Polyelectrolytes; Shells (structures); Interpenetrating polymer network (IPN); Microfluidic method; Poly(N-isopropyl acrylamide) (pNIPAM); Polyacrylic acids; Polyelectrolyte hydrogels; Sophisticated machines; Temperature-responsive; Weak polyelectrolytes; Calcium compounds | English | 2021 | 2021-07-25 | 10.1016/j.jiec.2021.04.032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds | Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 mu m pore size. PGA/HAp scaffolds containing 12.5 wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | Yeo, Taegyun; Ko, Young-Gwang; Kim, Eun Jin; Kwon, Oh Kyoung; Chung, Ho Yun; Kwon, Oh Hyeong | Kumoh Natl Inst Technol, Dept Polymer Sci & Engn, Gumi 39177, Gyeongbuk, South Korea; Therac Biomed Co Ltd, Seongnam 13201, Gyeonggi, South Korea; Kyungpook Natl Univ, Gastr Canc Ctr, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, CMRI, Daegu 41944, South Korea | Kim, Eun-Jin/I-1261-2019 | 57211190582; 35812149900; 55705551300; 26536109900; 7404007181; 55665582200 | ohkwon@kumoh.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 94 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2021 | 6.76 | 16.4 | 4.15 | 2025-07-30 | 55 | 63 | Hydroxyapatite; Poly(glycolic acid); 3D printing; Scaffold; Tissue engineering | 3D printing; Hydroxyapatite; Poly(glycolic acid); Scaffold; Tissue engineering | Biodegradation; Biomechanics; Compressive strength; Hydroxyapatite; Pore size; Scaffolds (biology); Tissue; Tissue regeneration; Animal experiments; Bone mineral density; Bone tissue regeneration; Composite scaffolds; Computer aided modeling; Hydroxyapatite (HAp); Poly(glycolic acid); Polyglycolic acids; 3D printers | English | 2021 | 2021-02-25 | 10.1016/j.jiec.2020.11.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Rose bengal conjugated gadolinium complex as a new multimodal imaging agent targeting presynaptic vesicular glutamate transporters | Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in progressive Alzheimer's disease (AD), VGLUTs can be a new imaging target for diagnosing AD. In this study, we have designed and synthesized a new multimodal gadolinium contrast agent conjugated with rose bengal to target VGLUTs (Gd-DO3A-RB). In addition to high kinetic and pH stability, magnetic resonance and fluorescence imaging using Gd-DO3A-RB showed high affinity to VGLUT1. Using the AD animal model (5XFAD), in vivo MRI with a Gd-DO3A-RB showed less MR signal enhancement in 5XFAD mouse brain than that of age-matched normal C57BL/6 mouse, suggesting a late stage decrease in VGLUT expression in AD animal model. Therefore, this new VGLUT targeting gadolinium contrast agent demonstrated a strong potential as a new diagnostic tool for AD with multimodal imaging capability. (c) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | Kim, Soyeon; Kim, Hee-Kyung; Baek, Ah Rum; Sung, Bokyung; Yang, Byeong Woo; Kim, Yeoun-Hee; Lee, Jung-jin; Yang, Ji-ung; Shin, Chang-Hoon; Jung, Hoesu; Kim, Minsup; Cho, Art E.; Lee, Taekwan; Chang, Yongmin | Kyungpook Natl Univ, Dept Med & Biol Engn, 80 Daehak Ro, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, 88 Dongnae Ro, Daegu 41061, South Korea; Mirae BioPharm Co, R&D Ctr, 124 Sagimakgol Ro, Gyeonggi Do 13207, South Korea; Korea Univ, Dept Bioinformat, Sejong Campus,2511 Sejong Ro, Sejong City 30019, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea | Yang, Byeong Woo/HII-8624-2022 | 57203773250; 56014729400; 57194601711; 58929528400; 57195807615; 57576538700; 10143410400; 57212217968; 58291543500; 58728242200; 56122945800; 8586262300; 55501335000; 7501840633 | taekwanlee@dgmif.re.kr;ychang@knu.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 95 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2021 | 6.76 | 16.4 | 0.35 | 2025-07-30 | 6 | 6 | Vesicular glutamate transporter; Rose Bengal; Gadolinium; Magnetic resonance imaging; Alzheimer's disease | Alzheimer's disease; Gadolinium; Magnetic resonance imaging; Rose Bengal; Vesicular glutamate transporter | Animals; Diagnosis; Fluorescence imaging; Magnetic resonance; Neurodegenerative diseases; Alzheimer's disease; Diagnostic tools; Gadolinium complexes; Gadolinium contrast agents; Glutamate transporters; High affinity; Multi-modal imaging; Multimodal imaging agents; Gadolinium compounds | English | 2021 | 2021-03-25 | 10.1016/j.jiec.2020.12.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Tannic acid-coated gold nanorod as a spectrometric probe for sensitive and selective detection of Al³⁺ in aqueous system | This work introduces an efficient probe for sensitive and selective detection of Al3+ based on gold nanorods (AuNRs) with tannic acid (TA) surface modification. TA, which contains five digalloyl ester groups covalently attached to a glucose core, exhibits preferential complexation and binding to Al3+, leading to the formation of side-by-side assembly of AuNRs and consequently inducing a change in the UV-vis absorbance spectra of their aqueous suspension. By increasing the Al3+ concentration to 7.4 mu M, a rapid, linear blue-shift in the longitudinal LSPR band and a decrease in its intensity are exhibited, with a 0.09 mu M limit of detection (LOD). Furthermore, the probe shows good selectivity to Al3+, along with the capability of detecting this cation in real water samples. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | Park, Ju Hyang; Seo, Ho Jun; Lu, Ping; Moon, Geon Dae; Hyun, Dong Choon | Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Korea Inst Ind Technol, Dongnam Reg Div, Busan 46938, South Korea; Rowan Univ, Dept Chem & Biochem, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA | ; Lu, Ping/D-4724-2011 | 57189227357; 57199231315; 57195511292; 23489708500; 15834575400 | gmoon@kitech.re.kr;dong.hyun@knu.ac.kr; | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | J IND ENG CHEM | 1226-086X | 1876-794X | 94 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2021 | 6.76 | 16.4 | 0.7 | 2025-07-30 | 11 | 11 | Gold nanorod; Tannic acid; Detection; Aluminum ion; Probe | COLORIMETRIC DETECTION; ALUMINUM; IONS; COORDINATION; CHEMOSENSOR; STRATEGY; PLATFORM; SENSOR | Aluminum ion; Detection; Gold nanorod; Probe; Tannic acid | Aluminum coatings; Blue shift; Flavonoids; Gold coatings; Gold Nanorods; Nanorods; Probes; Spectrometry; Tannins; Absorbance spectrum; Aqueous suspensions; Aqueous system; Gold nanorods (AuNRs); Limit of detection; Real water samples; Selective detection; Side by sides; Suspensions (fluids) | English | 2021 | 2021-02-25 | 10.1016/j.jiec.2020.11.025 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A basin-scale aquifer characterization using an inverse analysis based on groundwater level fluctuation in response to precipitation: Practical application to a watershed in Jeju Island, South Korea | Study Region: Gujwa Watershed, Jeju Island, South Korea Study Focus: In this study, we investigated whether basin-scale hydraulic properties can be inversely estimated using groundwater level fluctuation data. A geostatistical principal component adaptation evolution strategy was proposed as the inverse analysis method. It was applied to the Gujwa basin in Jeju Island. For the hypothetical case, the inverse simulation results accurately estimated the distribution and spatial structure of the hydraulic conductivity values. The quality of prior information insignificantly affected the proposed method; thus, it could be used as a critical reference method for groundwater management over a basin-scale area. New Hydrological Insight for the Region: The hydraulic characteristics of an actual aquifer can be characterized over an entire small watershed on the basis of the time-series data of the groundwater level fluctuation due to precipitation. The hydraulic properties estimated for this area correspond well to the geological features of the area that were not incorporated into the inverse analysis. Watershed-scale aquifer characterization is the most critical step in managing groundwater under the concept of watershed management. Owing to the reliability of the analysis, the estimates of aquifer hydraulic properties obtained from the proposed method can be used for various practical purposes, including establishing water resource management plans such as quantitative water resource management and groundwater pollution prevention. | Park, Eungyu; Kim, Kue-Young; Suk, Heejun | Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Korea Inst Geosci & Mineral Resources, Daejeon 34132, South Korea | 23995577700; 15029920800; 23996203400 | egpark@knu.ac.kr;kykim@kigam.re.kr;sxh60@kigam.re.kr; | JOURNAL OF HYDROLOGY-REGIONAL STUDIES | J HYDROL-REG STUD | 2214-5818 | 37 | SCIE | WATER RESOURCES | 2021 | 5.437 | 16.5 | 0.18 | 2025-07-30 | 5 | 5 | Basin-scale aquifer characterization; Geostatistical principal component adaptation; evolution strategy; Inverse analysis; Groundwater management; Jeju Island | STEADY-STATE; SUSTAINABILITY; TRANSMISSIVITY; UNCERTAINTY; RESOURCES; FIELDS; MODEL | Basin-scale aquifer characterization; Geostatistical principal component adaptation evolution strategy; Groundwater management; Inverse analysis; Jeju Island | English | 2021 | 2021-10 | 10.1016/j.ejrh.2021.100933 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Anti-Inflammatory Effect of Wasp Venom in BV-2 Microglial Cells in Comparison with Bee Venom | Simple Summary As the population of the yellow-legged hornet (Vespa velutina) spreads, this study investigated ways to utilize this resource of abundant invasive wasp species. Hymenoptera venoms, including bee venom and wasp venom, have therapeutic potential. Although the venoms are toxic to humans, the elucidation of their composition and working mechanisms has led to discoveries about their potential applications in treatment modalities for a variety of disorders. Therefore, we examined the anti-inflammatory effect of wasp venom from V. velutina in comparison with that of bee venom from honey bee on BV-2 murine microglial cells. Treatment with wasp venom reduced the secretion of nitric oxide and pro-inflammatory cytokines, including interleukin-6 and tumor necrosis factor alpha, from BV-2 cells activated by lipopolysaccharide (LPS). Western blot analysis revealed that wasp venom and bee venom decreased the expression levels of inflammation markers, including inducible nitric oxide synthase and cyclooxygenase-2. In addition, wasp venom decreased the nuclear translocation of nuclear factor kappa B (NF-kappa B), which is a key transcription factor in the regulation of cellular inflammatory response. Overall, the findings demonstrated that wasp venom inhibited LPS-induced inflammation in microglial cells by suppressing the NF-kappa B-mediated signaling pathway, which warrants further studies to confirm its therapeutic potential for neurodegenerative diseases. The aim of this study was to compare the anti-inflammatory effect of wasp venom (WV) from the yellow-legged hornet (Vespa velutina) with that of bee venom (BV) on BV-2 murine microglial cells. WV was collected from the venom sac, freeze-dried, and used for in vitro examinations. WV and BV were non-toxic to BV-2 cells at concentrations of 160 and 12 mu g/mL or lower, respectively. Treatment with WV reduced the secretion of nitric oxide and proinflammatory cytokines, including interleukin-6 and tumor necrosis factor alpha, from BV-2 cells activated by lipopolysaccharide (LPS). Western blot analysis revealed that WV and BV decreased the expression levels of inflammation markers, including inducible nitric oxide synthase and cyclooxygenase-2. In addition, WV decreased the nuclear translocation of nuclear factor kappa B (NF-kappa B), which is a key transcription factor in the regulation of cellular inflammatory response. Cumulatively, the results demonstrated that WV inhibited LPS-induced neuroinflammation in microglial cells by suppressing the NF-kappa B-mediated signaling pathway, which warrants further studies to confirm its therapeutic potential for neurodegenerative diseases. | Yun, Hyun Seok; Oh, Jisun; Lim, Ji Sun; Kim, Hyo Jung; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Natl Inst Korean Med Dev, Gyongsan 38540, South Korea | 57222627199; 56311554100; 57202909530; 55673631100; 37106950100 | solideo0116@naver.com;j.oh@knu.ac.kr;lzsunny@daum.net;indersee31@nikom.or.kr;vision@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 12 | 4 | SCIE | ENTOMOLOGY | 2021 | 3.141 | 16.5 | 2.4 | 2025-07-30 | 13 | 16 | Vespa velutina; wasp venom; microglia; neuroinflammation; NF-κ B | NF-KAPPA-B; YELLOW-LEGGED HORNET; VESPA-VELUTINA; NEURODEGENERATIVE DISORDERS; INFLAMMATION; ACTIVATION; MELITTIN; MODEL; NEUROINFLAMMATION; DISEASE | Microglia; Neuroinflammation; NF-κB; Vespa velutina; Wasp venom | English | 2021 | 2021-04 | 10.3390/insects12040297 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Coprecipitation Temperature Effects of Morphology-Controlled Nickel Hexacyanoferrate on the Electrochemical Performance in Aqueous Sodium-Ion Batteries | Coprecipitation effortlessly fabricated nickel hexacyanoferrate (NiHCF) with outstanding rate capability and stability for aqueous batteries. Citrate-aided coprecipitation decelerated the crystallization, assembling cubic-shaped powder based on separation between nucleation and growth. This study revealed that coprecipitation temperature determined the electrochemical performance. With lower temperatures, smaller particles with more water were formed by predominant nucleation, resulting in low crystallinity and capacity of 58 mAh g(-1). Expanded surface area reduced electrode/electrolyte interface charge-transfer resistance and showed excellent rate capability (79 % of initial capacity at 100 C-rate). However, poor cyclability was obtained. At elevated temperatures, nuclei growth and dehydration occurred, and thus highly crystalline large particles were formed. In turn, NiHCF delivered excellent capacity of 76 mAh g(-1) at 1 C-rate but exhibited inferior rate performance because of longer diffusional path. Meanwhile, normal coprecipitation at 70 degrees C induced irregular-shaped tiny particles, presenting 93 % retention of initial capacity at 100 C-rate. | Park, Sungjun; Kim, Jihwan; Yi, Seong-Hoon; Chun, Sang-Eun | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Yi, Seonghoon/HGC-6912-2022 | 57195715519; 58743659700; 14008383000; 36801080300 | sangeun@knu.ac.kr; | CHEMSUSCHEM | CHEMSUSCHEM | 1864-5631 | 1864-564X | 14 | 4 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2021 | 9.14 | 16.5 | 0.82 | 2025-07-30 | 23 | 22 | citrate ion; coprecipitation temperature; diffusional path; nickel hexacyanoferrate; rate capability | PRUSSIAN BLUE ANALOGS; CATHODE MATERIAL; SUPERIOR CATHODE; IRON HEXACYANOFERRATE; ELECTRODE MATERIALS; CRYSTAL-STRUCTURE; HIGH-CAPACITY; HIGH-VOLTAGE; INTERCALATION; LI | citrate ion; coprecipitation temperature; diffusional path; nickel hexacyanoferrate; rate capability | Charge transfer; Coprecipitation; Crystallinity; Crystallization; Fluorine compounds; Metal ions; Morphology; Nickel compounds; Nucleation; Co-precipitation temperature; Electrochemical performance; Electrode/electrolyte interfaces; Elevated temperature; Lower temperatures; Morphology-controlled; Nickel hexacyanoferrate; Nucleation and growth; Sodium-ion batteries | English | 2021 | 2021-02-18 | 10.1002/cssc.202002339 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Drop-casted Platinum Nanocube Catalysts for Hydrogen Evolution Reaction with Ultrahigh Mass Activity | Platinum hydrogen evolution reaction (HER) electrocatalysts in the form of nanocubes (NCs) were synthesized at 50 degrees C by aqueous-based colloidal synthesis and were applied to electrochemical (EC) and photoelectrochemical (PEC) systems by a fast and simple drop-casting method. A remarkable Pt mass activity of 1.77 A mg(-1) at -100 mV was achieved in EC systems (fluorine-doped tin oxide/Pt NC cathode) with neutral electrolyte while maintaining low overpotential and Tafel slope. In the Cu(In,Ga)(S,Se)(2) (CIGS)-based PEC system, a carefully chosen amount of Pt NC loading to achieve a compromise between the catalytic activity (more Pt NCs) and better light transmittance (fewer Pt NCs) led to a maximum onset potential of 0.678 V against the reference hydrogen electrode. The photoelectrodes with Pt NCs also exhibited good long-term operational stability over 9.5 h with negligible degradation of the photocurrent. This study presents an effective strategy to greatly reduce the use of expensive Pt without compromising the catalytic performance because the drop-casting of Pt NC solutions to form electrocatalysts is expected to waste less raw material than vacuum deposition. | Koo, Bonhyeong; Chu, Jinwoo; Seo, Jongsu; Jung, Gihun; Baek, Seung Hee; Nam, Sung-Wook; Duah, Calem; Lee, Young Kuk; Jung, WooChul; Shin, Byungha | Korea Adv Inst Sci & Technol KAIST, Dept Mat Sci & Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41405, South Korea; Korea Res Inst Chem Technol, Daejeon 34114, South Korea | ; Jung, WooChul/B-8725-2013; Shin, Byungha/E-8602-2014; Nam, Sung-Wook/V-5519-2019 | 38961401200; 57223655768; 57189469138; 57198355395; 57225718528; 16167127700; 57223642750; 36067081700; 27170700900; 8910734900 | leeyoung@krict.re.kr;wcjung@kaist.ac.kr;byungha@kaist.ac.kr; | CHEMSUSCHEM | CHEMSUSCHEM | 1864-5631 | 1864-564X | 14 | 12 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2021 | 9.14 | 16.5 | 0.33 | 2025-07-30 | 7 | 7 | drop-casting; hydrogen reduction; nanocubes; photoelectrochemistry; water splitting | CARBON NANOTUBES; NANOPARTICLES; SINGLE; ELECTROCATALYST; GRAPHENE; PHOTOCATHODE; EFFICIENCY; OXIDATION; DEVICE; PH | drop-casting; hydrogen reduction; nanocubes; photoelectrochemistry; water splitting | Catalyst activity; Drops; Electrocatalysts; Electrodes; Electrolytes; Hydrogen; Hydrogen evolution reaction; Nanocatalysts; Nanocomposites; Photocurrents; Photoelectrochemical cells; Sols; Tin oxides; Catalytic performance; Colloidal synthesis; Fluorine doped tin oxide; Hydrogen electrodes; Light transmittance; Neutral electrolytes; Operational stability; Photoelectrochemicals; Platinum | English | 2021 | 2021-06-21 | 10.1002/cssc.202100613 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | First Discovery of Vespa velutina nigrithorax du Buysson (Hymenoptera: Vespidae), an Invasive Hornet in the Feces of the Yellow-Throated Marten in South Korea | Simple Summary Invasive species can have serious economic and ecological effects. Biological controls are a way to reduce damage from invasive species. We collected 22 fecal samples from yellow-throated martens, which often prey on wasps in late autumn, from Mt. Onggangsan in Cheongdo, South Korea, to confirm the predation of the invasive alien hornet, Vespa velutina nigrithorax. Hornet debris was found in three samples, along with two native wasp species. The hornets were identified as one queen, four males, one female, and one individual whose caste was unclear. Therefore, because reproductive individuals were preyed upon, it is likely that yellow-throated marten predation could potentially be used for the biological control of invasive alien hornets. Yellow-throated martens (YTMs) are omnivores that often prey on wasps in late autumn in Korea. However, to the best of our knowledge, predation of the invasive alien species Vespa velutina nigrithorax (VVN) has not previously been investigated. In this study, YTM feces were collected and analyzed from Mt. Onggangsan, Sinwon-ri, Cheongdo, South Korea, where VVN density was high and YTMs were active. Surveys were conducted three times between October and December 2019, during which a total of 22 samples were collected. Debris from VVN was found in three samples, along with evidence of two indigenous wasps, Vespa crabro and Vespula koreensis. The VVN remains were identified as one queen, four males, one female, and one individual whose caste was unclear. Martens prey on wasps, owing to a sudden decrease in plant food sources from late autumn to early winter, mostly eating males and new queens attempting to mate. If VVN reproduction is prevented or disturbed by YTM predation, there may be potential biological control effects in areas with high VVN density. Further studies should be conducted to verify whether there is a practical biological control effect. | Kim, Chang-Jun; Choi, Moon Bo | Korea Natl Arboretum, Div Forest Biodivers, Pochon 11186, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | ; KIm, Changjun/GZM-7308-2022 | 55286588300; 51863232400 | changjunkim@korea.kr;kosinchoi@hanmail.net; | INSECTS | INSECTS | 2075-4450 | 12 | 4 | SCIE | ENTOMOLOGY | 2021 | 3.141 | 16.5 | 0.3 | 2025-07-30 | 3 | 3 | invasive alien species; feeding behavior; hornet; mammal; Martes flavigula; predator; wasp | Feeding behavior; Hornet; Invasive alien species; Mammal; Martes flavigula; Predator; Wasp | English | 2021 | 2021-04 | 10.3390/insects12040296 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genetic Relationship of Fall Armyworm (Spodoptera frugiperda) Populations That Invaded Africa and Asia | Simple Summary Since 2016, the fall armyworm, an important economic pest native to tropical and subtropical regions of the Western Hemisphere, has invaded Africa and further spread rapidly into most Asian countries. The fall armyworm is highly polyphagous, but two of its major strains, the corn and the rice strains, cause severe damage in the Western Hemisphere. However, the invaded populations in Africa and Asia mostly infested the corn fields. Studies on the genetic identity of the species using two molecular markers, one nuclear gene and one mitochondrial gene, showed that the major genetic group is a heterogeneous hybrid of males from the corn strain and females from the rice strain. Moreover, a minor group of homogenous individuals from the corn strain but no homogenous individuals from the rice strain were also detected. A geographic distribution analysis at the subpopulation level indicated similar genetic diversity in Africa and Asia, suggesting fall armyworm in Africa spread into Asia without significant genetic change. The fall armyworm, Spodoptera frugiperda, is an important agricultural pest native to tropical and subtropical regions of the Western Hemisphere, and has invaded Africa and further spread into most countries of Asia within two years. Here, we analyzed the genetic variation of invaded populations by comparing the nucleotide sequences of two genes: the nuclear Z-chromosome linked gene triose phosphate isomerase (Tpi) and the mitochondrial gene cytochrome oxidase subunit I (COI) of 27 specimens collected in Africa (DR Congo, Tanzania, Uganda, and Zimbabwe) and Asia (Bangladesh, Korea, Nepal, and Vietnam). The results revealed that 25 specimens were from a heterogeneous hybrid (Tpi-corn strain and COI-rice strain; Tpi-C/COI-R) of the corn strain male and rice strain female, but two specimens were from a homogenous corn strain (Tpi-corn strain and COI-corn strain; Tpi-C/COI-C). The further analysis of the fourth exon and the fourth intron sequences of the Tpi gene identified at least four subgroups of the corn strain. These four genetic subgroups were identified in Africa and Asia, suggesting no significant genetic change due to the rapid migration within two years. Our study provides essential information for understanding the genetic diversity of fall armyworm in new habitats. | Acharya, Rajendra; Akintola, Ashraf Akintayo; Malekera, Matabaro Joseph; Kamulegeya, Patrick; Nyakunga, Keneth Benedictor; Mutimbu, Munyaradzi Kennedy; Shrestha, Yam Kumar; Hemayet, Jahan S. M.; Trinh Xuan Hoat; Hang Thi Dao; Park, Jeong-Hoon; Kim, Iksoo; Nam, Moon; Lee, Sung-Jin; Kim, Sang-Mok; Hwang, Hwal-Su; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; Univ Ilorin, Fac Life Sci, Dept Zool, Ilorin 240212, Nigeria; Minist Agr, Dept Plants Protect, Kinshasa 8722, DEM REP CONGO; Minist Agr Anim Ind & Fisheries, POB 102, Entebbe, Uganda; Natl Biol Control, Kibaha 30031, Tanzania; Mutare Polytech Coll, Dept Appl Sci, POB 640, Mutare, Zimbabwe; Ctr Ind Entomol, Hariharbhawan 44700, Lalitpur, Nepal; Patuakhali Sci & Technol Univ, Dept Entomol, Dumki 8602, Patuakhali, Bangladesh; Plant Protect Res Inst, Hanoi 04, Vietnam; Jejudo Agr Res & Extens Serv, Jejudo 63556, South Korea; Chonnam Natl Univ, Coll Agr & Life Sci, Gwangju 61186, South Korea; Xenotype, Daejeon 34912, South Korea; Anim & Plant Quarantine Agcy, Plant Quarantine Technol Ctr, Gimcheon 39660, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu 41566, South Korea | Park, JeongHoon/MIJ-9586-2025; Lee, Seong-jin/AAL-8550-2021; Akintola, Ashraf/KZU-7081-2024; Acharya, Rajendra/AAG-6838-2020; Malekera, Matabaro/GRJ-3754-2022 | 57210568049; 57218618629; 57223964432; 57223983310; 57223976983; 57223965047; 36994050600; 55329416200; 14018002600; 56406220700; 57223991162; 8589660600; 57223963265; 56652527300; 35740741700; 57204055221; 57217153096 | racharya2048@gmail.com;ashraf.akintola@gmail.com;jmatabaro@live.com;pkamulegeya@yahoo.com;kennybenny83@yahoo.com;mmutimbu@gmail.com;ykshrestha@gmail.com;hemayet_pstu@yahoo.com;trinhxuanhoat.ppri@mard.gov.vn;daothihang@hotmail.com;pjh0221@korea.kr;ikkim81@chonnam.ac.kr;moonlit51@xenotype.co.kr;mycomania21@korea.kr;supraorder@korea.kr;bgtwo2@naver.com;leeky@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 12 | 5 | SCIE | ENTOMOLOGY | 2021 | 3.141 | 16.5 | 3.91 | 2025-07-30 | 27 | 27 | Spodoptera frugiperda; invasive pest; corn; invasion; COI; Tpi gene | SMITH LEPIDOPTERA-NOCTUIDAE; HOST STRAINS | COI; Corn; Invasion; Invasive pest; Spodoptera frugiperda; Tpi gene | English | 2021 | 2021-05 | 10.3390/insects12050439 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease | Background Although microbioa-based therapies have shown putative effects on the treatment of non-alcoholic fatty liver disease (NAFLD), it is not clear how microbiota-derived metabolites contribute to the prevention of NAFLD. We explored the metabolomic signature of Lactobacillus lactis and Pediococcus pentosaceus in NAFLD mice and its association in NAFLD patients. Methods We used Western diet-induced NAFLD mice, and L. lactis and P. pentosaceus were administered to animals in the drinking water at a concentration of 10(9) CFU/g for 8 weeks. NAFLD severity was determined based on liver/body weight, pathology and biochemistry markers. Caecal samples were collected for the metagenomics by 16S rRNA sequencing. Metabolite profiles were obtained from caecum, liver and serum. Human stool samples (healthy control [n = 22] and NAFLD patients [n = 23]) were collected to investigate clinical reproducibility for microbiota-derived metabolites signature and metabolomics biomarker. Results L. lactis and P. pentosaceus supplementation effectively normalized weight ratio, NAFLD activity score, biochemical markers, cytokines and gut-tight junction. While faecal microbiota varied according to the different treatments, key metabolic features including short chain fatty acids (SCFAs), bile acids (BAs) and tryptophan metabolites were analogously restored by both probiotic supplementations. The protective effects of indole compounds were validated with in vitro and in vivo models, including anti-inflammatory effects. The metabolomic signatures were replicated in NAFLD patients, accompanied by the comparable levels of Firmicutes/Bacteroidetes ratio, which was significantly higher (4.3) compared with control (0.6). Besides, the consequent biomarker panel with six stool metabolites (indole, BAs, and SCFAs) showed 0.922 (area under the curve) in the diagnosis of NAFLD. Conclusions NAFLD progression was robustly associated with metabolic dys-regulations in the SCFAs, bile acid and indole compounds, and NAFLD can be accurately diagnosed using the metabolites. L. lactis and P. pentosaceus ameliorate NAFLD progression by modulating gut metagenomic and metabolic environment, particularly tryptophan pathway, of the gut-liver axis. | Yu, Jeong Seok; Youn, Gi Soo; Choi, Jieun; Kim, Chang-Ho; Kim, Byung Yong; Yang, Seung-Jo; Lee, Je Hee; Park, Tae-Sik; Kim, Byoung Kook; Kim, Yeon Bee; Roh, Seong Woon; Min, Byeong Hyun; Park, Hee Jin; Yoon, Sang Jun; Lee, Na Young; Choi, Ye Rin; Kim, Hyeong Seob; Gupta, Haripriya; Sung, Hotaik; Han, Sang Hak; Suk, Ki Tae; Lee, Do Yup | Seoul Natl Univ, Res Inst Agr & Life Sci, Ctr Food & Bioconvergence, Dept Agr Biotechnol, Seoul 08826, South Korea; Hallym Univ, Inst Liver & Digest Dis, Chunchon, South Korea; ChunLab Inc, Seoul, South Korea; Gachon Univ, Dept Life Sci, Sungnam, South Korea; Chong Kun Dang Bio Res Inst, Gyeonggi Do, South Korea; World Inst Kimchi, Microbiol & Funct Res Grp, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Hallym Univ, Coll Med, Dept Pathol, Chunchon, South Korea | Roh, Seong/C-7688-2011; Gupta, Haripriya/ADF-9486-2022; Lee, Nayoung/LXB-5417-2024; Kim, Byung-Yong/JLL-7806-2023; Kim, Soo-Yeon/ADR-9663-2022; Kim, Won/H-6940-2019; Kim, Sukjun/AAV-8503-2021 | ktsuk@hallym.ac.kr;rome73@snu.ac.kr; | CLINICAL AND TRANSLATIONAL MEDICINE | CLIN TRANSL MED | 2001-1326 | 11 | 12 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;ONCOLOGY | 2021 | 8.554 | 16.5 | 101 | gut-liver axis; indole; metabolites; microbiome; non-alcoholic fatty liver disease | ACIDS; TRAITS; INJURY; NAFLD | English | 2021 | 2021-12 | 10.1002/ctm2.634 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Methyl Benzoate Is Superior to Other Natural Fumigants for Controlling the Indian Meal Moth (Plodia interpunctella) | Simple Summary Globally, the Indian meal moth is an insect pest of stored goods and manufactured foodstuffs. Synthetic fumigants, such as phosphine and methyl bromide, are widely used agents to control this species. However, due to the development of resistance and increasing concern about the potential adverse effects of synthetic fumigants, it is now necessary to identify environmentally friendly alternatives. Naturally occurring compounds, such as essential oils (EOs), are perhaps the most promising alternative sources; many have been successfully used as active ingredients in contact-based control products, repellents, and fumigants. Methyl benzoate (MBe) is an environmentally friendly, food-safe, natural insecticide that offers a possible alternative to synthetic equivalents. Here, we evaluated the fumigant toxicity of MBe against adults of the Indian meal moth and found that it had great potential for the control of these insect pests in stored products. The Indian meal moth, Plodia interpunctella (Hubner) (Lepidoptera: Pyralidae), is an insect pest that commonly affects stored and postharvest agricultural products. For the control of insect pests and mites, methyl benzoate (MBe) is lethal as a fumigant and also causes contact toxicity; although it has already been established as a food-safe natural product, the fumigation toxicity of MBe has yet to be demonstrated in P. interpunctella. Herein, we evaluated MBe as a potential fumigant for controlling adults of P. interpunctella in two bioassays. Compared to the monoterpenes examined under laboratory conditions, MBe demonstrated high fumigant activity using a 1-L glass bottle at 1 mu L/L air within 4 h of exposure. The median lethal concentration (LC50) of MBe was 0.1 mu L/L air; the median lethal time (LT50) of MBe at 0.1, 0.3, 0.5, and 1 mu L/L air was 3.8, 3.3, 2.8, and 2.0 h, respectively. Compared with commercially available monoterpene compounds used in pest control, MBe showed the highest fumigant toxicity (toxicity order as follows): MBe > citronellal > linalool > 1,8 cineole > limonene. Moreover, in a larger space assay, MBe caused 100% mortality of P. interpunctella at 0.01 mu L/cm(3) of air after 24 h of exposure. Therefore, MBe can be recommended for use in food security programs as an ecofriendly alternative fumigant. Specifically, it provides another management tool for curtailing the loss of stored food commodities due to P. interpunctella infestation. | Mostafiz, Md Munir; Hassan, Errol; Acharya, Rajendra; Shim, Jae-Kyoung; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; Univ Queensland Gatton, Sch Agr & Food Sci, Gatton, Qld 4343, Australia; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Quantum Dot Fus Sci & Technol, Gunwi 39061, South Korea | ; Acharya, Rajendra/AAG-6838-2020; Mostafiz, Md. Munir/AAD-7664-2019 | 57204895546; 16458195700; 57210568049; 7201856347; 57217153096 | munirmostafiz12@gmail.com;e.hassan@uq.edu.au;racharya2048@gmail.com;astelia@naver.com;leeky@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 12 | 1 | SCIE | ENTOMOLOGY | 2021 | 3.141 | 16.5 | 2.4 | 2025-07-30 | 21 | 21 | stored-product insect; fumigation toxicity; naturally available compound; monoterpenes | Fumigation toxicity; Monoterpenes; Naturally available compound; Stored-product insect | English | 2021 | 2021-01 | 10.3390/insects12010023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea | Simple SummaryLyme borreliosis is caused by a spirochete from the Borrelia burgdorferi sensu lato group. Borrelia afzelii and B. garinii are known to be pathogenic to humans. The main vector for Lyme borreliosis is the Ixodes tick. In this study, Borrelia infection was confirmed in Ixodes, Haemaphysalis, and Amblyomma ticks. To our knowledge Borrelia infection was first confirmed in Amblyomma testudinarium in Korea. Based on phylogenetic analysis, all sequences were aligned with B. afzelii isolates and showed a close relationship with high identity. Considering that B. afzelii causes infectious zoonotic diseases, continuous monitoring and attention are still required (although a low prevalence was recorded in this study).Ticks are vectors that spread pathogenic bacteria, viruses, and protozoa. As the number of ticks increases due to climate change, the importance of the study of tick-borne pathogens has also increased. This study was conducted to investigate the distribution of the major tick species causing Lyme borreliosis and regional differences in the prevalence of Borrelia spp. by tick species. Borrelia infection was confirmed not only in Ixodes ticks, which are the major vectors of Borrelia spp., but also in Haemaphysalis and Amblyomma ticks. PCR targeting the 5S-23S rRNA intergenic spacer region (rrf-rrl) was performed to confirm Borrelia positivity. A total of 6102 ticks (736 pools) were tested, and the proportion was Haemaphysalis longicornis nymphs and adults at 69.2%, Haemaphysalis flava nymphs and adults at 13.9%, Haemaphysalis spp. larva at 14.3%, Ixodes nipponensis at 0.8%, and Amblyomma testudinarium at 1.9%. Ixodes nipponensis showed the highest minimum infection rate (MIR: 34.00; 17 pools/50 ticks) for Borrelia spp., followed by A. testudinarium (MIR: 0.88), and H. longicornis (MIR: 0.05). In particular, to our knowledge Borrelia infection was first confirmed in A. testudinarium in Korea. As a result of phylogenetic analysis, all sequences were grouped with Borrelia afzelii isolates and showed a close relationship with high identity. Considering that B. afzelii causes infectious zoonotic diseases, continuous monitoring and attention are needed, although it has a low prevalence in this study. | Lee, Haeseung; Lee, Seung-Hun; Shin, SungShik; Kwak, Dongmi | Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Chungbuk Natl Univ, Coll Vet Med, 1 Chungdae Ro, Cheongju 28644, South Korea; Chonnam Natl Univ, Coll Vet Med, 77 Yongbong Ro, Gwangju 61186, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57202497862; 57203394416; 7403646673; 7007148758 | lhs1457@knu.ac.kr;dvmshlee@chungbuk.ac.kr;sungshik@jnu.ac.kr;dmkwak@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 12 | 11 | SCIE | ENTOMOLOGY | 2021 | 3.141 | 16.5 | 1.35 | 2025-07-30 | 9 | 9 | Borrelia; Korea; phylogeny; tick; tick-borne pathogen | WILD | Borrelia; Korea; Phylogeny; Tick; Tick-borne pathogen | English | 2021 | 2021-11 | 10.3390/insects12111011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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