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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Gender -based examination of the association between individual symptoms of alcohol use disorder, major depressive disorder, and suicidal behaviors: a network analysis of data from the Korean Epidemiologic Catchment Area Study | Shim, Eun-Jung; Ha, Hyeju; Park, Jee Eun; Kim, Byung-Soo; Chang, Sung Man; Hong, Jin Pyo; Cho, Maeng Je; Hahm, Bong-Jin | Pusan Natl Univ, Dept Psychol, Busan, South Korea; Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat & Behav Sci, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Dept Psychiat, Seoul, South Korea | Hahm, Bong-Jin/J-5714-2012; Kim, Byung-Soo/H-4047-2013; Ha, Hyeju/AAC-6080-2019 | 36617933300; 57197825716; 56119414400; 57214661242; 23092756400; 55729426400; 57049717000; 6601908426 | hahmbj@gmail.com; | JOURNAL OF AFFECTIVE DISORDERS | J AFFECT DISORDERS | 0165-0327 | 1573-2517 | 272 | SCIE;SSCI | CLINICAL NEUROLOGY;PSYCHIATRY | 2020 | 4.839 | 17.0 | 1.23 | 2025-06-25 | 19 | 17 | COMORBID DEPRESSION; COPING DRINKING; SUBSTANCE USE; RISK; WORTHLESSNESS; PSYCHOPATHOLOGY; METAANALYSIS; ADOLESCENCE; SELECTION; FEELINGS | Alcohol use disorder; major depressive disorder; network analysis; suicide; worthlessness | Alcoholism; Cross-Sectional Studies; Depressive Disorder, Major; Female; Humans; Male; Republic of Korea; Suicidal Ideation; alcoholism; Article; cross-sectional study; female; guilt; human; hypersomnia; insomnia; major clinical study; major depression; male; priority journal; sex difference; suicidal behavior; suicidal ideation; suicide attempt; alcoholism; major depression; South Korea | English | 2020 | 2020-07-01 | 10.1016/j.jad.2020.03.162 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Power Transmission Efficiency Analysis of 42 kW Power Agricultural Tractor According to Tillage Depth during Moldboard Plowing | In order to optimize tractor design and optimize efficiency during tillage operation, it is essential to verify the impact through field tests on factors affecting the tractor load. The objectives of this study were to investigate the effect of tillage depth on power transmission efficiency of 42 kW power agricultural tractor during moldboard plowing. A load measurement system and a tillage depth measurement system were configured for field tests. To analyze the effect of tillage depth on power transmission efficiency and fuel consumption, the data measured in the three-repeated field test were classified according to tillage depth. As the tillage depth increased from 11 cm at the top of the hardpan to 23 cm at the deepest, the required power of the engine increased by approximately 13% from 35.48 kW to 40.11 kW, and the power transmission efficiency also increased significantly from 66% to 95%. Among them, the power transmission efficiency of the rear axle was significantly increased from 38% to 59%, which was the most affected. As the tillage depth increased, the overall power requirement is greatly increased due to the resulting workload, but the fuel consumption and the specific fuel consumption are reduced because the engine speed of the tractor is reduced. As the tillage depth increased from 11 cm to 23 cm, the fuel consumption rate was rather reduced by 13.5% as the engine rotational speed decreased 11.3% due to the increase work load of tractor. In addition, the specific fuel consumption decreased from 302.44 g/kWh to 236.93 g/kWh, showing a fuel consumption saving of up to 21.7% during moldboard plow. In addition, as the tillage depth increased, the ratio of the value excluding the mechanical and hydraulic power requirements has significantly decreased from 34% to 5% as the power transmission efficiency increases. This study considers the soil properties according to the soil depth, as well as the power transmission efficiency and fuel consumption rate. The research results can provide useful information for research on power transmission efficiency and selection of an appropriate power source of agricultural tractor according to tillage depth during moldboard plowing and are expected to be used in various ways as basic studies of digital farming research in agricultural machinery. | Kim, Yeon-Soo; Kim, Wan-Soo; Siddique, Md Abu Ayub; Baek, Seung-Yun; Baek, Seung-Min; Cheon, Su-Hwan; Lee, Sang-Dae; Lee, Kyeong-Hwan; Hong, Dong-Hyuck; Park, Seong-Un; Kim, Yong-Joo | Chungnam Natl Univ, Dept Biosyst Machinery Engn, Daejeon 34134, South Korea; Korea Inst Ind Technol KITECH, Smart Agr Machinery R&D Grp, Gimje 54325, South Korea; Chungnam Natl Univ, Dept Smart Agr Syst, Daejeon 34134, South Korea; Chonnam Natl Univ, Dept Rural & Biosyst Engn, Gwangju 61186, South Korea; Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu 41566, South Korea; Tongyang Moolsan Co Ltd, Res & Dev Inst, Gongju 32530, South Korea | Lee, Sang-Woong/ABF-6191-2020; Siddique, PhD, Md. Abu Ayub/AAB-6607-2021; Kim, Soo-Yeon/ADR-9663-2022; Kim, Yong-Joo/AAK-1840-2021 | 57192923355; 57192918810; 57192431042; 57216612175; 57204040500; 57973205100; 59845799100; 55671368800; 57192068978; 57213917936; 57204759454 | kimtech612@gmail.com;wskim0726@gmail.com;engg.ayub64@gmail.com;kelpie0037@gmail.com;bsm1104@naver.com;ctgstory@kitech.re.kr;sdlee96@kitech.re.kr;khlee@chonnam.ac.kr;bear0011@knu.ac.kr;psu@tym.co.kr;babina@cnu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 10 | 9 | SCIE | AGRONOMY;PLANT SCIENCES | 2020 | 3.417 | 17.0 | 1.51 | 2025-06-25 | 22 | 22 | agricultural tractor; tillage depth; power transmission efficiency; power requirements; fuel efficiency; moldboard plowing | SOIL PHYSICAL-PROPERTIES; ENERGY-REQUIREMENTS; FUEL CONSUMPTION; GROWTH; DEFORMATION; PERFORMANCE; COMPACTION; FORCES; ENGINE; YIELD | Agricultural tractor; Fuel efficiency; Moldboard plowing; Power requirements; Power transmission efficiency; Tillage depth | English | 2020 | 2020-09 | 10.3390/agronomy10091263 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Response of Soil Bacterial Community and Pepper Plant Growth to Application of Bacillus thuringiensis KNU-07 | Many Bacillus species are among the plant growth-promoting rhizobacteria (PGPR) that promote the growth of many different plant species. This study aimed to investigate the effects of Bacillus thuringiensis KNU-07 on the growth of pepper plants and the soil microbiota. We also designed primers specific for the strain KNU-07 to monitor the population in pepper-cultivated soil. Accordingly, a strain-specific primer pair was designed using a database constructed from 16,160 complete bacterial genomes. We employed quantitative PCR (qPCR) to track the abundance of the strain KNU-07 introduced into pepper-cultivated soil using the strain-specific primers. Our study revealed that the strain was found to possess plant growth-promoting (PGP) activities, and it promoted the growth of pepper plants. The soil bacterial community structure due to the application of the PGPR strain was significantly changed after six weeks post-inoculation. In addition, based on qPCR analysis, the population of the introduced strain declined over time. In this study, application of a PGPR strain increased the growth of pepper plants and changed the soil bacterial community structure. The successful results of monitoring of a bacterial strain's population using a single strain-specific primer pair can provide important information about the quantification of bio-inoculants under non-sterile soil conditions. | Jo, HyungWoo; Tagele, Setu Bazie; Huy Quang Pham; Kim, Min-Chul; Choi, Seung-Dae; Kim, Min-Ji; Park, Yeong-Jun; Ibal, Jerald Conrad; Park, Gun-Seok; Shin, Jae-Ho | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; COSMAX BTI Inc, R&I Ctr, Seongnam Si 13486, Gyeonggi Do, South Korea; Atogen Co Ltd, Daejeon 34015, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | ; Pham, Quang/AAB-3064-2022; Ibal, Jerald/JYQ-0493-2024; Tagele, Setu Bazie/IYJ-1959-2023 | 57197827666; 57202007103; 57200503445; 57203466596; 57215651369; 57127351600; 56275800900; 57196117664; 55357605300; 57224125922 | hyungwoo0501@gmail.com;setubazie@gmail.com;huypham@knu.ac.kr;skalscjf13@naver.com;csd506@knu.ac.kr;tbd01188@knu.ac.kr;yjpark1091@knu.ac.kr;jerald.ibal@gmail.com;gspark@atogen.co.kr;jhshin@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 10 | 4 | SCIE | AGRONOMY;PLANT SCIENCES | 2020 | 3.417 | 17.0 | 1.51 | 2025-06-25 | 20 | 18 | Bacillus thuringiensis; Capsicum annuum; PGPR; microbiome; strain-specific primer; tracking | PROMOTING RHIZOBACTERIA; COLONIZATION; STRAIN; INCREASES; PHOSPHATE; ROOTS | Bacillus thuringiensis; Capsicum annuum; Microbiome; PGPR; Strain-specific primer; Tracking | English | 2020 | 2020-04 | 10.3390/agronomy10040551 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Screening and Identification of Brown Planthopper Resistance Genes OsCM9 in Rice | The brown planthopper (BPH) is a major pest that causes serious damage to rice in countries with mild climates, including Korea, Japan, China, and Vietnam. Although a large number of BPH-resistant genes have been reported, BPH has recently evolved rapidly and in a variable manner due to rapid climate change and an unpredictable environment. The synthesis of secondary metabolites in plants is essential, as it provides resistance to various stressors, including pests such as BPH. For QTL mapping, a Samgang/Nagdong double haploid (SNDH) 113 population was used. The BPH resistance gene was screening by measure the resistance score using the phenotype that appeared after BPH inoculation in the 113 SNDH population. QTL mapping was used, and SSR marker RM584-RM225 of chromosome 6 and SSR marker RM331-S8024 of chromosome 8 were commonly identified. These locations contained transcription factors, phytohormones, signaling molecules, kinases, and secondary metabolites that defend plants from stressors in the environment. This region of chromosome 8 also contained a sequence similar to that of rice Choristmate mutase (OsCM9). CM is a gene that is not only found in rice, but also in thale cress (Arabidopsis thaliana (L.) Heynh.), maize (Zea mays L.), and soybean (Glycine max (L.) Merr.). After inoculation with BPH, the relative expression levels of OsCM9 were greater in the line resistant to BPH than in the line susceptible to BPH. The newly identified BPH-resistant gene OsCM9 can be used for the development of rice varieties that are capable of resisting sudden damage due to BPH, as the evolution of BPH due to climate change has had negative impacts on rice crops. | Park, Jae-Ryoung; Yun, Sopheap; Jan, Rahmatullah; Kim, Kyung-Min | Kyungpook Natl Univ, Sch Appl Biosci, Coll Agr & Life Sci, Div Plant Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Royal Univ Phnom Penh, Grad Sch Sci, Sangkat Teuk Laak 1,Russian Federat Blvd, Toul Kork, Phnom Penh, Cambodia | ; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/AIC-3439-2022 | 57211205505; 57190670675; 57201981969; 34868260300 | icd92@naver.com;yunsopheap@gmail.com;rehmatbot@yahoo.com;kkm@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 10 | 12 | SCIE | AGRONOMY;PLANT SCIENCES | 2020 | 3.417 | 17.0 | 0.5 | 2025-06-25 | 8 | 8 | brown planthopper; quantitative trait loci; rice; secondary metabolite; double haploid line | QUANTITATIVE TRAIT LOCI; NILAPARVATA-LUGENS STAL; SALICYLIC-ACID; SYNTHASE; ORYZA; QTLS; MECHANISMS; GENETICS; QUALITY | Brown planthopper; Double haploid line; Quantitative trait loci; Rice; Secondary metabolite | English | 2020 | 2020-12 | 10.3390/agronomy10121865 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | The Prospect of Bentazone-Tolerant Soybean for Conventional Cultivation | Soybean is one of the most important crops widely used as food, feed, and industrial products. Weeds compete with the crops for light, nutrients, water, space, and other growth requirements, causing an average yield reduction of 37% in soybean. Bentazone is an herbicide that selectively kills broadleaf weeds by inhibiting photosynthesis. It is widespread in soybean-cultivating areas including genetically modified organism (GMO) and GMO-free regions all around the world. This herbicide carries a double-edged sword since it can also incur damage to crops upon application. The challenge, therefore, lies in the deliberate selection of bentazone-tolerant cultivars. We systematically analyzed several factors that affect the metabolism of bentazone in soybean, such as phenotypic and genotypic differences among soybean accessions, the time and method of application, the absorption and metabolism of bentazone in soybean, and the effects of effective application and cultivar selection on yield and crop injury. Furthermore, we recommend that further studies should be done in aid of discovering more tolerant soybean cultivars. We hope that our review will help farmers and soybean producers, as well as geneticists, in developing bentazone-tolerant soybean cultivars to improve the global yield of soybean crops as a response to the ever-dynamic food demand across the globe. | Ali, Liakat; Jo, Hyun; Song, Jong Tae; Lee, Jeong-Dong | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Bangabandhu Sheikh Mujibur Rahman Agr Univ, Fac Agr, Dept Genet & Plant Breeding, Gazipur 1706, Bangladesh | 36908067800; 57194539358; 57797134000; 40462075100 | liakat.gpb@bsmrau.edu.bd;johyun@knu.ac.kr;jtsong68@knu.ac.kr;jdlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 10 | 11 | SCIE | AGRONOMY;PLANT SCIENCES | 2020 | 3.417 | 17.0 | 0.29 | 2025-06-25 | 10 | 11 | soybean; bentazone; photosystem-II inhibitor; cytochrome P450; enzymatic detoxification | BROADLEAF WEED-CONTROL; GLYCINE-MAX; DIFFERENTIAL RESPONSE; HERBICIDE RESISTANCE; GENOTYPIC VARIATION; CAPSICUM-ANNUUM; GLYPHOSATE; METABOLISM; METRIBUZIN; EFFICACY | Bentazone; Cytochrome P450; Enzymatic detoxification; Photosystem-II inhibitor; Soybean | English | 2020 | 2020-11 | 10.3390/agronomy10111650 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Group system: An efficient dynamic memory management scheme for real-time systems | While dynamic memory management (DMM) has been widely used as one of the basic elements of computer systems, it has been rarely used in real-time systems. DMM in real-time systems must exhibit fast execution, high memory efficiency, and predictable execution time. However, it is difficult to design a DMM scheme that simultaneously satisfies all of these requirements, and therefore DMM has not been widely used in real-time systems. This study proposes a new DMM scheme, named group system, that simultaneously satisfies the three requirements of real-time systems. The new DMM scheme is an extension of buddy systems and provides significantly improved memory efficiency compared to buddy systems while maintaining the advantage of the predictable execution time of buddy systems. Group system shows a slightly better worst-case execution time (WCET) than buddy systems that are known to exhibit excellent execution time, and shows memory efficiency that is close to that of the best fit scheme that is known to have excellent memory efficiency. | Park, Sung Ho; Jeong, Seol Young; Kang, Soon Ju | Kyungpook Natl Univ, Ctr Self Organizing Software Platform, 80,Daehak Ro, Daegu, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, 80,Daehak Ro, Daegu, South Korea | 37049190600; 57215189985; 55666313900 | sunghopark@knu.ac.kr;snowflower@ee.knu.ac.kr;sjkang@ee.knu.ac.kr; | JOURNAL OF SYSTEMS ARCHITECTURE | J SYST ARCHITECT | 1383-7621 | 1873-6165 | 107 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, SOFTWARE ENGINEERING | 2020 | 3.777 | 17.1 | 0 | 2025-06-25 | 0 | 0 | Dynamic memory management; Heap management; Real-time systems; Buddy systems; Memory fragmentation | PERFORMANCE; ALLOCATOR | Buddy systems; Dynamic memory management; Heap management; Memory fragmentation; Real-time systems | Efficiency; Interactive computer systems; Storage allocation (computer); Basic elements; Buddy systems; Dynamic memory management; Group systems; High memory efficiencies; Memory efficiency; Memory fragmentation; Worst-case execution time; Real time systems | English | 2020 | 2020-08 | 10.1016/j.sysarc.2020.101726 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Surface passivation of zinc ferrite nanorod photoanodes by spray-deposited silicon oxide layer for enhanced solar water splitting | ZnFe2O4 nanorods (NR's) were prepared by a chemical conversion method from beta-FeOOH NRs grown on FTO substrates. To activate their photoactivity of ZnFe2O4 NRs for solar water splitting, the surface passivation was achieved with SiO2 layer via facile and effective spray pyrolysis method. The presence of SiO2 layer enhances the photocurrent density of the Pristine ZnFe2O4 from 143 mu A/cm(2) to 212 mu A/cm(2) at 1.23 V-RHE for 0.25 mM Si-ZnFe2O4, representing two time increment in the photocurrent density. The influences of amount of Si precursor (Tetraethyl orthosilicate) solutions on the physical properties and the passivation effect of SiO2/ZnFe2O4 interfaces were investigated. This improved photoresponse of the Si-treated ZnFe2O4 NRs was attributed to the excellent charge transfer electrode/electrolyte interface. The effectively improved charge transfer properties of the Si-treated ZnFe2O4 NRs were demonstrated by the electrochemical impedance spectroscopy (EIS), Mott-Schottky (MS) and intensity-modulated photocurrent spectroscopy (IMPS) analyses. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved. | Ma, Haiqing; Mahadik, Mahadeo A.; Kim, Sa Rang; Wang, Miao; Ryu, Hyeon Ih; Chung, Hee Suk; Chae, Weon Sik; Park, Hyunwoong; Jang, Jum Sul | Chonbuk Natl Univ, Div Biotechnol, Coll Environm & Bioresource Sci, Iksan 54596, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Jeonju Ctr, Korea Basic Sci Inst, Jeonju 54907, South Korea; Daegu Ctr, Korea Basic Sci Inst, Daegu 41566, South Korea | ; Mahadik, Mahadeo/GOK-1899-2022; Park, Hyunwoong/A-1247-2012; Ma, Haiqing/KYQ-5267-2024 | 57205063861; 55253739200; 57212493933; 57212492803; 57201326090; 24280695300; 7003277427; 7601565583; 56523777600 | hwp@knu.ac.kr;jangjs75@jbnu.ac.kr; | JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS | J TAIWAN INST CHEM E | 1876-1070 | 1876-1089 | 107 | SCIE | ENGINEERING, CHEMICAL | 2020 | 5.876 | 17.1 | 0.24 | 2025-06-25 | 7 | 7 | Solar water splitting; ZnFe2O4 nanorods; Spray pyrolysis; SiO2 passivation layer | NANOSTRUCTURED HEMATITE PHOTOANODES; HYDROGEN GENERATION; EFFICIENT; ZNFE2O4; ARRAYS; FILMS; PERFORMANCE; OXIDATION; SI; FABRICATION | SiO<sub>2</sub> passivation layer; Solar water splitting; Spray pyrolysis; ZnFe<sub>2</sub>O<sub>4</sub> nanorods | Charge transfer; Electrochemical impedance spectroscopy; Nanorods; Passivation; Photocurrents; Silica; Silicon oxides; Spray pyrolysis; Zinc; Zinc compounds; Charge transfer properties; Electrode/electrolyte interfaces; Intensity modulated photocurrent spectroscopy (IMPS); Passivation layer; Solar water splitting; Spray pyrolysis method; Tetra-ethyl-ortho-silicate; ZnFe2O4; Iron compounds | English | 2020 | 2020-02 | 10.1016/j.jtice.2019.11.014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of dissolution pathways of polyacrylonitrile on the solution homogeneity: Thermodynamic- or kinetic-controlled dissolution | Dissolution behavior of polyacrylontrile (PAN) in N,N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO) is investigated in terms of dipole-dipole interactions at polymer-solvent interface. Fourier-transformed infrared (FTIR) imaging of polymer-solvent interface under static dissolution condition at 25 degrees C and 60 degrees C exhibits the gel-like swollen layer in the early stage of dissolution for both solvents. This layer readily disappears in PAN-DMSO and DMSO molecules penetrate deep into the polymer phase, whereas that in PAN-DMF is still observed until 12 h even at 60 degrees C. The better dissolving ability of DMSO is interpreted by higher intrinsic viscosity and lower Huggins' constant. The solubility (solution homogeneity) is also evaluated by rheological analysis in a wide concentration range of 8-20 wt%. At above 15 wt%, DMSO produces homogeneous solution at 60 degrees C even without stirring, showing the lower Newtonian flow region. On the other hand, it is necessary to apply vigorous stirring and heating for PAN-DMF system in order to prepare concentrated solution. DMSO provides greater slope of the Cole-Cole plot by rheological measurement than DMF, indicating better solution homogeneity in PAN-DMSO. The FTIR spectra and 2D correlation analysis show that both DMSO and DMF dissolve PAN in a way of sequential contributions of enthalpic and entropic factors. However, DMSO exhibits predominant contribution by enthalpic factor, suggesting that enthalpy change of mixing is a driving force of PAN dissolution in DMSO, whereas dissolution of PAN-DMF is governed by kinetic control. | Eom, Youngho; Ju, Hyejin; Park, Yeonju; Chae, Dong Wook; Jung, Young Mee; Kim, Byoung Chul; Chae, Han Gi | Pukyong Natl Univ, Dept Polymer Engn, Busan 48513, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Sch Mat Sci & Engn, Ulsan 44919, South Korea; Kangwon Natl Univ, Inst Mol Sci & Fus Technol, Dept Chem, Chunchon 24341, South Korea; Kyungpook Natl Univ, Dept Text Engn, Sangju 37224, South Korea; Hanyang Univ, Dept Organ & Nano Engn, 222 Wangsimni Ro, Seoul 04763, South Korea | Chae, Han Gi/M-5427-2016; Eom, Youngho/U-6387-2019; Kim, In-Ryoung/AGF-2385-2022 | 56108103900; 57210206704; 35362452500; 7006246752; 56497404700; 55726501300; 58256600000 | ymjung@kangwon.ac.kr;bckim@hanyang.ac.kr;hgchae@unist.ac.kr; | POLYMER | POLYMER | 0032-3861 | 1873-2291 | 205 | SCIE | POLYMER SCIENCE | 2020 | 4.43 | 17.2 | 0.86 | 2025-06-25 | 21 | 21 | Polyacrylonitrile; Dissolution; Thermodynamics and kinetics | HIGHLY ISOTACTIC POLYACRYLONITRILE; POLYMER DISSOLUTION; N,N-DIMETHYLFORMAMIDE DERIVATIVES; SOLVENT MIXTURES; REFRACTIVE-INDEX; BEHAVIOR; CELLULOSE; FTIR; DIMETHYLSULFOXIDE; SOLUBILITY | Dissolution; Polyacrylonitrile; Thermodynamics and kinetics | Dimethylformamide; Dissolution; Fourier transform infrared spectroscopy; Polymers; Solution mining; 2D correlation analysis; Concentrated solution; Concentration ranges; Dipole dipole interactions; Dissolution behavior; Homogeneous solutions; N ,N-Dimethylformamide; Rheological measurements; Organic solvents | English | 2020 | 2020-09-28 | 10.1016/j.polymer.2020.122697 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Expeditious and eco-friendly solution-free self-patterning of sol-gel oxide semiconductor thin films | Due to its simplicity and low-cost manufacturing, self-patterning has been considered a promising candidate to replace conventional photolithography. However, most solution-based self-patterning methods require toxic materials, lengthy processes and generate extensive material waste, thus hindering eco-friendly and also economic mass production. Therefore, this work presents an expeditious and eco-friendly solution-free self-patterning method to fabricate patterned indium gallium zinc oxide (IGZO) thin-film transistors (TFTs). This faster and simpler two-step process requires within only 10 min to generate the selective wetting and dewetting regions on the dielectrics via a simultaneous stampi ng and thermal treatment (SST) and then an ultraviolet ozone exposure. As a result, well-defined IGZO patterns were formed without residues. Extremely suppressed lateral and vertical leakage currents were obtained in self-patterned IGZO TFTs by eliminating leakage paths found in non-patterned devices (appx. 10(-11) A versus 10(-5) A, respectively). Furthermore, the recyclability of the surface energy modification stamp (SEMS) used in the proposed SST process was confirmed, as the IGZO patterns and uniform electrical performances remained dear through nine patterning processes using a single SEMS. Overall, the proposed solution-free self-patterning method will contribute to the realization of next-generation printed electronics by enabling their mass production. (C) 2020 The Author(s). Published by Elsevier Ltd. | Kim, Do-Kyung; Park, Jun-Ik; Jang, Jaewon; Kang, In Man; Park, Jaehoon; Bae, Jin-Hyuk | Kyungpook Natl Univ, Sch Elect Engn, Daehakro 80, Daegu 41566, South Korea; Hallym Univ, Dept Elect Engn, Chunchon 24252, South Korea | 57984042900; 57210189987; 57194107504; 7203062678; 55717156300; 35326180700 | jhbae@ee.knu.ac.kr; | MATERIALS & DESIGN | MATER DESIGN | 0264-1275 | 1873-4197 | 194 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 7.991 | 17.2 | 0.42 | 2025-06-25 | 9 | 8 | Oxide semiconductor; Sol-gel; Self-patterning; Solution-free; Eco-friendly; Leakage currents | TRANSISTORS; ALIGNMENT | Eco-friendly; Leakage currents; Oxide semiconductor; Self-patterning; Solution-free; Sol–gel | Electronics industry; Environmental protection; Gallium compounds; II-VI semiconductors; Leakage currents; Oxide films; Oxide semiconductors; Semiconducting indium compounds; Sols; Thin films; Toxic materials; Zinc oxide; Conventional photolithography; Electrical performance; Energy modification; Indium-gallium-zinc-oxide thin-film transistors (tfts) (IGZO); Low cost manufacturing; Printed electronics; Semiconductor thin films; Wetting and de-wetting; Thin film transistors | English | 2020 | 2020-09 | 10.1016/j.matdes.2020.108949 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Host Immunosuppression Induced by Steinernema feltiae, an Entomopathogenic Nematode, through Inhibition of Eicosanoid Biosynthesis | Steinernema feltiae K1 (Filipjev) (Nematode: Steinernematidae), an entomopathogenic nematode, was isolated and identified based on its morphological and molecular diagnostic characteristics. Its infective juveniles (IJs) were highly pathogenic to three lepidopteran (LC50 = 23.7-25.0 IJs/larva) and one coleopteran (LC50 = 39.3 IJs/larva) insect species. Infected larvae of the diamondback moth, Plutella xylostella (L.) (Insecta: Lepidoptera), exhibited significant reduction in phospholipase A(2) (PLA(2)) activity in their plasma. The decrease of PLA(2) activity was followed by significant septicemia of the larvae infected with S. feltiae. Insecticidal activity induced by S. feltiae was explained by significant immunosuppression in cellular immune responses measured by hemocyte nodule formation and total hemocyte count (THC). Although S. feltiae infection suppressed nodule formation and THC in the larvae, an addition of arachidonic acid (AA, a catalytic product of PLA(2)) rescued these larvae from fatal immunosuppression. In contrast, an addition of dexamethasone (a specific PLA(2) inhibitor) enhanced the nematode's pathogenicity in a dose-dependent manner. To discriminate the immunosuppressive activity of a symbiotic bacterium (Xenorhabdus bovienii (Proteobacteria: Enterobacterales)) from the nematode, kanamycin was applied to after nematode infection. It significantly inhibited the bacterial growth in the hemolymph. Compared to nematode treatment alone, the addition of antibiotics to nematode infection partially rescued the immunosuppression measured by phenol oxidase activity. Consequently, treatment with antibiotics significantly rescued the larvae from the insecticidal activity of S. feltiae. These results suggest that immunosuppression induced by infection of S. feltiae depends on its symbiotic bacteria by inhibiting eicosanoid biosynthesis, resulting in significant insect mortality. However, the addition of antibiotics or AA could not completely rescue the virulence of the nematode, suggesting that the nematode itself also plays a role in its insecticidal activity. | Roy, Miltan Chandra; Lee, Dongwoon; Kim, Yonggyun | Andong Natl Univ, Dept Plant Med, Andong 36729, South Korea; Kyungpook Natl Univ, Sch Environm Ecol & Tourism, Sangju 37224, South Korea | 57213165149; 7406669991; 59662780600 | miltan.roy@yahoo.com;whitegrub@knu.ac.kr;hosanna@anu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 11 | 1 | SCIE | ENTOMOLOGY | 2020 | 2.769 | 17.2 | 1.29 | 2025-06-25 | 12 | 12 | Steinernema feltiae; eicosanoids; PLA(2); Plutella xylostella; immunosuppression | ANTIMICROBIAL PEPTIDES; SYMBIOTIC BACTERIA; PHOSPHOLIPASE A(2); IMMUNE-RESPONSES; BEET ARMYWORM; XENORHABDUS; PHOTORHABDUS; DROSOPHILA; REGIONS; STRAIN | Eicosanoids; Immunosuppression; PLA2; Plutella xylostella; Steinernema feltiae | English | 2020 | 2020-01 | 10.3390/insects11010033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Lethal and Sublethal Effects of Methyl Benzoate on the Predatory BugNesidiocoris tenuis | Benzoates (naturally occurring plant toxins) produce pesticidal effects on various pest insects and mites, but their effects on non-target insects are poorly understood. In this study, we evaluate the lethal and sublethal toxicity of methyl benzoate (MB) to adults of the generalist predatory bugNesidiocoris tenuis(Reuter) (Hemiptera: Miridae). To assess lethal effects,N. tenuiswas exposed to plant surfaces treated with 0.25%, 0.5% and 1% MB, as well as negative and positive controls (water and the neonicotinoid acetamiprid, respectively). Exposure to 1% MB resulted in the highest corrected mortality of 17.8% and 13.3% under laboratory and greenhouse conditions, respectively. Thus, 1% MB can be classified as harmless toN. tenuisaccording to the International Organization for Biological Control rating scheme. At the sublethal level, MB exposure did not significantly affect the consumption of eggs of the whiteflyBemisia tabacibyN. tenuisrelative to negative control feeding rates. In contrast, acetamiprid at the manufacturer's recommended concentration reducedN. tenuisfeeding activity by 45.4%. Furthermore, in a Y-tube olfactometer assay, there were no significant differences between the olfactory responses ofN. tenuisto MB concentrations and the negative control (water). This study therefore suggests that MB could be used safely for pest control in combination withN. tenuis. | Mostafiz, Md Munir; Hassan, Errol; Shim, Jae-Kyoung; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Div Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea; Univ Queensland Gatton, Sch Agr & Food Sci, Gatton, Qld 4343, Australia; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sustainable Agr Res Ctr, Gunwi 39061, South Korea | ; Mostafiz, Md. Munir/AAD-7664-2019 | 57204895546; 16458195700; 7201856347; 57217153096 | munirmostafiz12@gmail.com;e.hassan@uq.edu.au;astelia@naver.com;leeky@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 11 | 6 | SCIE | ENTOMOLOGY | 2020 | 2.769 | 17.2 | 2.16 | 2025-06-25 | 18 | 18 | biopesticides; natural compound; natural enemy; Nesidiocoris tenuis; sustainable agriculture | PLANT ESSENTIAL OILS; TETRANYCHUS-URTICAE ACARI; TUTA-ABSOLUTA; NESIDIOCORIS-TENUIS; BEMISIA-TABACI; BIOLOGICAL-CONTROL; LIFE-HISTORY; PESTICIDES; TOXICITY; HEMIPTERA | Biopesticides; Natural compound; Natural enemy; Nesidiocoris tenuis; Sustainable agriculture | English | 2020 | 2020-06 | 10.3390/insects11060377 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Susceptibility of Various Developmental Stages of the Fall Armyworm, Spodoptera frugiperda, to Entomopathogenic Nematodes | Simple Summary The fall armyworm, Spodoptera frugiperda, native to Central and South America, has recently invaded Africa and Asia, causing serious economic damage to various crops. The chemical control of fall armyworm is not effective due to the development of pesticide resistance as well as environmental contamination. Alternatively, biological control using natural enemies can be used successfully in a sustainable way. Entomopathogenic nematodes are soil-dwelling natural enemies for many underground pest insects including lepidopteran caterpillars. This study evaluates the virulence of several entomopathogenic nematodes on different developmental stages of fall armyworm. We found that all the larval and pupal stages of fall armyworm were highly susceptible to the entomopathogenic nematodes. Our study provides important information of entomopathogenic nematodes for the practical application of biological control of fall armyworm. The fall armyworm, Spodoptera frugiperda, which is native to Central and South America, has recently invaded Africa and Asia, causing serious damage to various crops. Although management to date has been largely unsuccessful, entomopathogenic nematodes (EPNs) are a potential biological control agent that could be used to control the late larval and pupal stages of S. frugiperda that dwell under the ground. Here, we compared the virulence of seven EPNs against larval and pupal stages of S. frugiperda. In a Petri dish assay, both Heterorhabditis indica and Steinernema carpocapsae were highly virulent against younger larvae, whereas S. arenarium and S. longicaudum were highly virulent against older larvae. In contrast, H. bacteriophora, Heterorhabditis sp., and S. kushidai showed low virulence against all larval stages. In soil column and pot assays, H. indica, S. carpocapsae, and S. longicaudum were highly virulent against late larval and pupal stages compared with the other EPN species. Thus, H. indica, S. carpocapsae, and S. longicaudum are recommended for the biological control of S. frugiperda. Our study provides important information of EPNs for the practical application of biological control of fall armyworm. | Acharya, Rajendra; Hwang, Hwal-Su; Mostafiz, Md Munir; Yu, Yeon-Su; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Quantum Bio Res Ctr, Gunwi 39061, South Korea; Daedong Tech, Gyongsan 38401, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | ; Mostafiz, Md. Munir/AAD-7664-2019; Acharya, Rajendra/AAG-6838-2020 | 57210568049; 57204055221; 57204895546; 56143693500; 57217153096 | racharya2048@gmail.com;bgtwo2@naver.com;munirmostafiz12@gmail.com;ysyu1973@naver.com;leeky@knu.ac.kr; | INSECTS | INSECTS | 2075-4450 | 11 | 12 | SCIE | ENTOMOLOGY | 2020 | 2.769 | 17.2 | 4.74 | 2025-06-25 | 58 | 63 | biological control; alien invasive species; virulence assays; Heterorhabditis indica; Steinernema carpocapsae; Steinernema longicaudum; sustainable management | LEPIDOPTERA-NOCTUIDAE; ENTOMOGENOUS NEMATODE; RHABDITIDA STEINERNEMATIDAE; LITURA LEPIDOPTERA; INFECTIVITY; LARVAE; HETERORHABDITIDAE; CARPOCAPSAE; EFFICACY; PATHOGENICITY | Alien invasive species; Biological control; Heterorhabditis indica; Steinernema carpocapsae; Steinernema longicaudum; Sustainable management; Virulence assays | English | 2020 | 2020-12 | 10.3390/insects11120868 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data | Background Nivolumab showed improvement in overall survival (OS) in ATTRACTION-2, the first phase 3 study in patients with gastric/gastroesophageal junction (G/GEJ) cancer treated with >= 2 chemotherapy regimens. The 2-year follow-up results of ATTRACTION-2 are presented herein. Methods ATTRACTION-2 was a randomized, double-blind, placebo-controlled, phase 3 trial (49 sites; Japan, South Korea, and Taiwan). The median (min-max) follow-up period was 27.3 (24.1-36.3) months. The primary endpoint was OS. A subanalysis of OS was performed based on best overall response and tumor-programmed death ligand-1 (PD-L1) expression status. Results Overall, 493 of 601 screened patients were randomized (2:1) to receive nivolumab (330) or placebo (163). OS (median [95% confidence interval; CI]) was significantly longer in the nivolumab group (5.26 [4.60-6.37] vs 4.14 [3.42-4.86] months in placebo group) at the 2-year follow-up (hazard ratio [95% CI], 0.62 [0.51-0.76]; P < 0.0001). A higher OS rate was observed in the nivolumab vs placebo group at 1 (27.3% vs 11.6%) and 2 years (10.6% vs 3.2%). The OS benefit was observed regardless of tumor PD-L1 expression. Among patients with a complete or partial response (CR or PR) in the nivolumab group, the median OS (95% CI) was 26.6 (21.65-not applicable) months; the OS rates at 1 and 2 years were 87.1% and 61.3%, respectively. No new safety signals were identified. Conclusions Nivolumab treatment resulted in clinically meaningful long-term improvements in OS in patients with previously treated G/GEJ cancer. The long-term survival benefit of nivolumab was most evident in patients with a CR or PR. | Chen, Li-Tzong; Satoh, Taroh; Ryu, Min-Hee; Chao, Yee; Kato, Ken; Chung, Hyun Cheol; Chen, Jen-Shi; Muro, Kei; Kang, Won Ki; Yeh, Kun-Huei; Yoshikawa, Takaki; Oh, Sang Cheul; Bai, Li-Yuan; Tamura, Takao; Lee, Keun-Wook; Hamamoto, Yasuo; Kim, Jong Gwang; Chin, Keisho; Oh, Do-Youn; Minashi, Keiko; Cho, Jae Yong; Tsuda, Masahiro; Sameshima, Hiroki; Kang, Yoon-Koo; Boku, Narikazu | Natl Cheng Kung Univ, Natl Inst Canc Res, Natl Hlth Res Inst, Tainan, Taiwan; Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan; Osaka Univ, Frontier Sci Canc & Chemotherapy, Grad Sch Med, Suita, Osaka, Japan; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Taipei Vet Gen Hosp, Dept Oncol, Taipei, Taiwan; Natl Canc Ctr, Div Gastrointestinal Med Oncol, Chuo Ku, 5-1-1 Tsukiji, Tokyo, Japan; Yonsei Univ, Yonsei Univ Hlth Syst, Song Dang Inst Canc Res, Div Med Oncol,Yonsei Canc Ctr,Coll Med, Seoul, South Korea; Chang Gung Univ, Linkou Chang Gung Mem Hosp, Dept Internal Med, Div Hematol & Oncol, Taoyuan, Taiwan; Aichi Canc Ctr Hosp, Dept Clin Oncol, Nagoya, Aichi, Japan; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Natl Taiwan Univ, Canc Ctr, Taipei, Taiwan; Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Oncol, Coll Med, Taipei, Taiwan; Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan; Korea Univ, Coll Med, Dept Internal Med, Div Hematol & Oncol, Seoul, South Korea; China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taichung, Taiwan; Kindai Univ, Fac Med, Dept Med Oncol, Osakasayama, Japan; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Hematol & Oncol,Coll Med, Seongnam, South Korea; Keio Univ, Keio Canc Ctr, Sch Med, Tokyo, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Japanese Fdn Canc Res, Dept Gastroenterol, Canc Inst Hosp, Tokyo, Japan; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chiba Canc Ctr, Clin Trial Promot Dept, Chiba, Japan; Yonsei Univ, Gangnam Severance Hosp, Dept Med Oncol, Coll Med, Seoul, South Korea; Hyogo Canc Ctr, Dept Gastroenterol Oncol, Akashi, Hyogo, Japan; Ono Pharmaceut Co Ltd, Med Oncol Med Affairs, Osaka, Japan; Natl Canc Ctr, Dept Gastr Surg, Tokyo, Japan; Kindai Univ, Dept Med Oncol, Nara Hosp, Ikoma, Japan | ; Chung, Hyun Cheol/AFB-8969-2022; Yoshikawa, Takaki/Y-1580-2019; Satoh, Taroh/AAF-7913-2020; Yeh, Kun-Huei/HGD-3316-2022; Hamamoto, Yasuo/AAA-9941-2022; Kang, Yoon-Koo/ABL-4264-2022; Chen, Jen-Shi/GLV-3349-2022 | 7409440415; 12040860900; 7101754860; 7402865850; 56502463000; 7404006815; 35075804900; 7006195808; 7202402198; 7201438906; 7402718437; 55647062500; 7201957490; 7403453308; 35205887300; 7103060946; 34771414000; 7202995470; 8836932000; 6506466850; 36805119200; 56012668900; 57212550493; 7402784198; 55359026700 | nboku@ncc.go.jp; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 23 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2020 | 7.37 | 17.6 | 9.69 | 2025-06-25 | 187 | 177 | Gastric cancer; Gastroesophageal junction cancer; Long-term; Nivolumab; Placebo | SQUAMOUS-CELL CARCINOMA; JAPANESE PATIENTS; DOUBLE-BLIND; DOCETAXEL; EFFICACY; MELANOMA; SAFETY; TRIAL; HEAD | Gastric cancer; Gastroesophageal junction cancer; Long-term; Nivolumab; Placebo | Aged; Antineoplastic Agents, Immunological; Double-Blind Method; Esophageal Neoplasms; Esophagogastric Junction; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Nivolumab; Prognosis; Republic of Korea; Salvage Therapy; Stomach Neoplasms; Survival Rate; Taiwan; nivolumab; placebo; programmed death 1 ligand 1; immunological antineoplastic agent; nivolumab; adult; advanced cancer; aged; Article; controlled study; disease exacerbation; double blind procedure; drug efficacy; drug safety; drug withdrawal; esophagus cancer; female; follow up; gastroesophageal junction; human; human tissue; interstitial lung disease; Japan; maculopapular rash; major clinical study; male; overall survival; phase 3 clinical trial; pneumonia; priority journal; progression free survival; randomized controlled trial; South Korea; stomach cancer; Taiwan; treatment duration; treatment response; tumor growth; clinical trial; drug effect; esophagus tumor; gastroesophageal junction; middle aged; multicenter study; pathology; prognosis; salvage therapy; stomach tumor; survival rate | English | 2020 | 2020-05 | 10.1007/s10120-019-01034-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Exploratory subgroup analysis of patients with prior trastuzumab use in the ATTRACTION-2 trial: a randomized phase III clinical trial investigating the efficacy and safety of nivolumab in patients with advanced gastric/gastroesophageal junction cancer | Background Data on immune checkpoint inhibitor efficacy in patients with human epidermal growth factor receptor 2-positive (HER2+) advanced gastric/gastroesophageal junction (G/GEJ) cancer are lacking. Because HER2 status was not captured in the ATTRACTION-2 trial, we used patients with prior trastuzumab use (Tmab+) as surrogate for HER2 expression status to evaluate the efficacy and safety of nivolumab as third- or later-line therapy in these patients. Methods In ATTRACTION-2, a randomized, double-blind, placebo-controlled, phase 3 multicenter trial, patients were randomized (2:1) to receive nivolumab (3 mg/kg) or placebo every 2 weeks until disease progression or toxicity requiring study discontinuation. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and safety were assessed. Results Of 493 enrolled patients, 81 (nivolumab, n = 59; placebo, n = 22) were Tmab+ and 412 (nivolumab, n = 271; placebo, n = 141) were Tmab-. In both groups, patients receiving nivolumab showed a longer median OS vs placebo (Tmab+, 8.3 [95% confidence interval, 5.3-12.9] vs 3.1 [1.9-5.3] months, hazard ratio, 0.38 [0.22-0.66]; P = 0.0006; Tmab-, 4.8 [4.1-6.0] vs 4.2 [3.6-4.9] months, 0.71 [0.57-0.88]; P = 0.0022). PFS was longer in both groups receiving nivolumab vs placebo (Tmab+, 1.6 [1.5-4.0] vs 1.5 [1.3-2.9] months, 0.49 [0.29-0.85]; P = 0.0111; Tmab-, 1.6 [1.5-2.4] vs 1.5 [1.5-1.5] months, 0.64 [0.51-0.80]; P = 0.0001). Conclusions Nivolumab was efficacious and safe as third- or later-line therapy regardless of prior trastuzumab use in patients with advanced G/GEJ cancer. | Satoh, Taroh; Kang, Yoon-Koo; Chao, Yee; Ryu, Min-Hee; Kato, Ken; Cheol Chung, Hyun; Chen, Jen-Shi; Muro, Kei; Ki Kang, Won; Yeh, Kun-Huei; Yoshikawa, Takaki; Oh, Sang Cheul; Bai, Li-Yuan; Tamura, Takao; Lee, Keun-Wook; Hamamoto, Yasuo; Kim, Jong Gwang; Chin, Keisho; Oh, Do-Youn; Minashi, Keiko; Cho, Jae Yong; Tsuda, Masahiro; Tanimoto, Mitsunobu; Chen, Li-Tzong; Boku, Narikazu | Osaka Univ, Grad Sch Med, Frontier Sci Canc & Chemotherapy, Suita, Osaka, Japan; Univ Ulsan, Coll Med, Dept Oncol, Asan Med Ctr, Seoul, South Korea; Taipei Vet Gen Hosp, Dept Oncol, Taipei, Taiwan; Natl Canc Ctr, Div Gastrointestinal Med Oncol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan; Yonsei Univ, Yonsei Univ Hlth Syst, Song Dang Inst Canc Res, Yonsei Canc Ctr,Div Med Oncol,Coll Med, Seoul, South Korea; Chang Gung Univ, Linkou Chang Gung Mem Hosp, Dept Internal Med, Div Hematol & Oncol, Taoyuan, Taiwan; Aichi Canc Ctr Hosp, Dept Clin Oncol, Nagoya, Aichi, Japan; Sungkyunkwan Univ, Samsung Med Ctr, Div Hematol Oncol, Dept Med,Sch Med, Seoul, South Korea; Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan; Natl Taiwan Univ, Ctr Canc, Taipei, Taiwan; Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan; Natl Canc Ctr, Dept Gastr Surg, Tokyo, Japan; Korea Univ, Dept Internal Med, Div Hematol & Oncol, Coll Med, Seoul, South Korea; China Med Univ, China Med Univ Hosp, Div Hematol & Oncol, Dept Internal Med, Taichung, Taiwan; Kindai Univ, Fac Med, Dept Med Oncol, Osaka, Japan; Kindai Univ, Nara Hosp, Dept Med Oncol, Ikoma, Japan; Seoul Natl Univ, Bundang Hosp, Div Hematol & Oncol, Dept Internal Med,Coll Med, Seongnam, South Korea; Keio Univ, Keio Canc Ctr, Sch Med, Tokyo, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Hosp Japanese Fdn Canc Res, Inst Canc, Dept Gastroenterol, Tokyo, Japan; Seoul Natl Univ, Seoul Natl Univ Hosp, Canc Res Inst, Dept Internal Med,Coll Med, Seoul, South Korea; Chiba Canc Ctr, Clin Trial Promot Dept, Chiba, Japan; Yonsei Univ, Gangnam Severance Hosp, Dept Med Oncol, Coll Med, Seoul, South Korea; Hyogo Canc Ctr, Dept Gastroenterol Oncol, Akashi, Hyogo, Japan; ONO Pharmaceut Co Ltd, Oncol Clin Dev Unit, Oncol Clin Dev Planning, Osaka, Japan; Natl Cheng Kung Univ, Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan; Natl Cheng Kung Univ, Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan | Chung, Hyun Cheol/AFB-8969-2022; Hamamoto, Yasuo/AAA-9941-2022; Yoshikawa, Takaki/Y-1580-2019; Chen, Jen-Shi/GLV-3349-2022; Yeh, Kun-Huei/HGD-3316-2022; Kang, Yoon-Koo/ABL-4264-2022; Satoh, Taroh/AAF-5193-2021; Lee, Juhyung/JQV-8143-2023 | 12040860900; 7402784198; 7402865850; 7101754860; 56502463000; 7404006815; 35075804900; 7006195808; 36138652200; 7201438906; 7402718437; 55647062500; 7201957490; 7403453308; 35205887300; 7103060946; 34771414000; 7202995470; 8836932000; 6506466850; 36805119200; 56012668900; 55993122400; 7409440415; 55359026700 | nboku@ncc.go.jp; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 23 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2020 | 7.37 | 17.6 | 2.99 | 2025-06-25 | 54 | 52 | Nivolumab; Gastric cancer; Gastroesophageal junction cancer; Trastuzumab | GASTRIC-CANCER; LAPATINIB; PD-L1; HER2 | Gastric cancer; Gastroesophageal junction cancer; Nivolumab; Trastuzumab | Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Immunological; Double-Blind Method; Esophageal Neoplasms; Esophagogastric Junction; Female; Humans; Male; Middle Aged; Nivolumab; Placebos; Stomach Neoplasms; Trastuzumab; Treatment Outcome; immunological antineoplastic agent; nivolumab; placebo; trastuzumab; adult; aged; clinical trial; controlled study; double blind procedure; esophagus tumor; female; gastroesophageal junction; human; male; middle aged; mortality; pathology; phase 3 clinical trial; randomized controlled trial; stomach tumor; treatment outcome; very elderly | English | 2020 | 2020-01 | 10.1007/s10120-019-00970-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2 | Background Spasmolytic polypeptide-expressing metaplasia (SPEM) is considered a precursor lesion of intestinal metaplasia and intestinal-type gastric cancer (GC), but little is known about microRNA alterations during metaplasia and GC developments. Here, we investigate miR-30a expression in gastric lesions and identify its novel target gene which is associated with the intestinal-type GC. Methods We conducted in situ hybridization and qRT-PCR to determine miR-30a expression in gastric tissues. miR-30a functions were determined through induction or inhibition of miR-30a in GC cell lines. A gene microarray was utilized to confirm miR-30a target genes in GC, and siRNA-mediated target gene suppression and immunostaining were performed. The Cancer Genome Atlas data were utilized to validate gene expressions. Results We found down-regulation of miR-30a during chief cell transdifferentiation into SPEM. MiR-30a level was also reduced in the early stage of GC, and its level was maintained in advanced GC. We identified a novel target gene of miR-30a and ITGA2, and our results showed that either ectopic expression of miR-30a or ITGA2 knockdown suppressed GC cell proliferation, migration, and tumorigenesis. Levels of ITGA2 inversely correlated with levels of miR-30a in human intestinal-type GC. Conclusion We found down-regulation of miR-30a in preneoplastic lesions and its tumor-suppressive functions by targeting ITGA2 in GC. The level of ITGA2, which functions as an oncogene, was up-regulated in human GC. The results of this study suggest that coordination of the miR-30a-ITGA2 axis may serve as an important mechanism in the development of gastric precancerous lesions and intestinal-type GC. | Min, Jimin; Han, Tae-Su; Sohn, Yoojin; Shimizu, Takahiro; Choi, Boram; Bae, Seong-Woo; Hur, Keun; Kong, Seong-Ho; Suh, Yun-Suhk; Lee, Hyuk-Joon; Kim, Jang-Seong; Min, Jeong-Ki; Kim, Woo-Ho; Kim, V. Narry; Choi, Eunyoung; Goldenring, James R.; Yang, Han-Kwang | Seoul Natl Univ, Coll Med, Canc Res Inst, 101 Daehak Ro, Seoul, South Korea; Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South Korea; KRIBB, Daejeon, South Korea; Vanderbilt Univ, Sch Med, Nashville VA Med Ctr, Nashville, TN 37212 USA; Vanderbilt Univ, Sch Med, Dept Surg, Nashville, TN 37212 USA; Vanderbilt Univ, Sch Med, Epithelial Biol Ctr, Med Ctr, MRB 4 10435F,2213 Garland Ave, Nashville, TN 37232 USA; Vanderbilt Univ, Sch Med, Cell & Dev Biol, Nashville, TN 37212 USA; Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea | ; Sohn, Yoojin/AAY-2375-2021; Sohn, Yoojin/M-4616-2018; Yang, Han-Kwang/J-2767-2012; CHOI, EUNYOUNG/KQU-5508-2024; Hur, Keun/G-9513-2011 | 56893110600; 26424339800; 57211895584; 55728477900; 56174136800; 57215507582; 8861888000; 55641926600; 39062470900; 7501481303; 7601388220; 7201919982; 57218663587; 7102754775; 54884548100; 7101924503; 7406557280 | eunyoung.choi@vumc.org;jim.goldenring@vumc.org;hkyang@snu.ac.kr; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 23 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2020 | 7.37 | 17.6 | 1.31 | 2025-06-25 | 20 | 21 | miR-30a; ITGA2; Metaplasia; Gastric cancer; Tumor suppressor | POLYPEPTIDE-EXPRESSING METAPLASIA; DECREASES MULTIDRUG-RESISTANCE; TO-MESENCHYMAL TRANSITION; CANCER CELLS; COLORECTAL-CANCER; TUMOR-SUPPRESSOR; MIR-30A; GROWTH; PROMOTES; INVASION | Gastric cancer; ITGA2; Metaplasia; miR-30a; Tumor suppressor | Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha2; Intestinal Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; MicroRNAs; Prognosis; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; microRNA; microRNA 30a; small interfering RNA; unclassified drug; alpha2 integrin; microRNA; MIRN30 microRNA, human; tumor marker; advanced cancer; animal experiment; animal model; Article; cancer staging; cell migration; cell proliferation; cell transdifferentiation; colony formation; controlled study; disease association; down regulation; ectopic expression; female; gene expression regulation; gene knockdown; gene repression; gene targeting; human; human cell; immunohistochemistry; in situ hybridization; ITGA2 gene; mouse; nonhuman; oncogene; priority journal; real time polymerase chain reaction; stomach cancer; stomach carcinogenesis; stomach tissue; upregulation; validation process; animal; apoptosis; Bagg albino mouse; C57BL mouse; carcinogenesis; cell motion; drug screening; gene expression regulation; genetics; intestine tumor; male; metabolism; nude mouse; pathology; prognosis; stomach tumor; tumor cell culture | English | 2020 | 2020-07 | 10.1007/s10120-020-01052-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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