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○ ○ Review ⓘ Dysregulated immune cell responses in severe dengue pathogenesis ⓘ Life-threatening severe dengue (SD) develops in a small subset of patients suffering from dengue fever (DF), a febrile disease that develops following infection with dengue virus (DENV). DENV is a mosquito-borne positive -sense RNA virus. The rapid spread of DENV vectors, which was exacerbated by climate change and inadequate control measures, has led to outbreaks affecting millions worldwide. There is no specific treatment for DF, and the recently introduced vaccines are ineffective in containing the current outbreaks. Like many other viral diseases, the immune system plays a key role in dengue pathogenesis. The lack of models replicating the disease's immunopathological features has hampered the understanding of the immune system's role in developing this disease. Recent advances, such as single-cell approaches, provide better systems and methodologies to study the role of different immune cells in SD, closing this gap and providing a better mechanistic understanding of disease pathogenesis and promoting the identification of targets for therapeutic interventions. Here, we summarize recent advances in SD research, focusing on immune cell interactions and their role in disease severity. ⓘ Yoo, Ji-Seung; Shporn, Oron Zvi; Sklan, Ella H. ⓘ Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Tel Aviv Univ, Fac Med & Hlth Sci, Dept Clin Microbiol & Immunol, Tel Aviv, Israel; Tel Aviv Med Ctr, Dept Internal Med T, Tel Aviv, Israel ⓘ Sklan, Ella/MSW-8581-2025; Yoo, Ji-Seung/KHD-6177-2024 ⓘ 59510752300; 59928499300; 6507052815 ⓘ sklan@tauex.tau.ac.il; ⓘ FRONTIERS IN IMMUNOLOGY ⓘ FRONT IMMUNOL ⓘ 1664-3224 16 SCIE IMMUNOLOGY ⓘ 2024 5.9 17.2 0 2025-06-11 ⓘ 0 0 dengue virus; severe dengue; dengue fever; immunopathogenesis; immune dysfunction; cytokine production ⓘ BLOOD MONONUCLEAR-CELLS; ORIGINAL ANTIGENIC SIN; HUMAN DENDRITIC CELLS; VIRUS-INFECTION; MAST-CELLS; NK CELLS; T-CELLS; NEUTROPHIL ELASTASE; CYTOKINE PRODUCTION; HEMORRHAGIC-FEVER ⓘ cytokine production; dengue fever; dengue virus; immune dysfunction; immunopathogenesis; severe dengue ⓘ Animals; Dengue; Dengue Virus; Humans; Severe Dengue; cell interaction; climate change; cytokine production; dengue; Dengue virus; etiology; immune deficiency; immune system; immunocompetent cell; immunopathogenesis; nonhuman; pathogenesis; positive-strand RNA virus; review; severe dengue; severity of illness index; animal; human; immunology; pathology; virology ⓘ English 2025 2025-05-21 10.3389/fimmu.2025.1600999 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Joint estimation of hand-foot-mouth disease model and prediction in korea using the ensemble kalman filter ⓘ Background In Korea, Hand-foot-and-mouth disease (HFMD) is a recurring illness that presents significant public health challenges, primarily because of its unpredictable epidemic patterns. The accurate prediction of the spread of HFMD plays a vital role in the effective management of the disease.Methods We have devised a dynamic model that accurately represents the transmission dynamics of HFMD. The model includes compartments for susceptible, exposed, inpatients, outpatients, recovered, and deceased individuals. By utilizing monthly inpatient and outpatient data, the ensemble Kalman filter (EnKF) method was employed to perform a joint estimation of model parameters and state variables. The calibration of model parameters involved using data from the months of January to May, while generating forecasts for the timeframe spanning from June to December.Results The findings reveal a significant alignment between the model and the observed data, as evidenced by root-mean-square error (RMSE) values below 1000 for inpatients and below 10000 for outpatients starting in June. The correlation coefficients surpassed 0.9, except for the year 2015. The implications of our findings suggest a notable shift in transmission and recovery rates, starting in 2015.Discussion The model successfully predicted the peak and magnitude of HFMD outbreaks occurring between June and December, closely matching the observed epidemic patterns. The model's efficacy in predicting epidemic trends and informing preventive strategies is reinforced by the insights gained from monthly variations in parameter estimates of HFMD transmission dynamics. ⓘ Abbas, Wasim; Lee, Sieun; Kim, Sangil ⓘ Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Daegu, South Korea; Pusan Natl Univ, Innovat Ctr MathSci Res & Educ, Busan, South Korea; Pusan Natl Univ, Dept Math, Busan, South Korea; Pusan Natl Univ, Inst Future Earth, Busan, South Korea ⓘ ⓘ 57871336100; 57972716100; 34978723300 ⓘ sangil.kim@pusan.ac.kr; ⓘ PLOS COMPUTATIONAL BIOLOGY ⓘ PLOS COMPUT BIOL ⓘ 1553-734X 1553-7358 21 4 SCIE BIOCHEMICAL RESEARCH METHODS;MATHEMATICAL & COMPUTATIONAL BIOLOGY ⓘ 2024 3.6 17.2 0 2025-05-07 ⓘ 0 0 ⓘ TRANSMISSION; HFMD ⓘ ⓘ Computational Biology; Disease Outbreaks; Hand, Foot and Mouth Disease; Humans; Models, Biological; Models, Statistical; Republic of Korea; Diseases; Mean square error; Prediction models; Accurate prediction; Disease models; Dynamics models; Effective management; Ensemble Kalman Filter; Foot and mouth disease; Joint estimation; Modeling parameters; Modelling and predictions; Transmission dynamics; algorithm; Article; calibration; correlation coefficient; covariance; diagnostic test accuracy study; disease transmission; ensemble kalman filter; genetic algorithm; hand foot and mouth disease; health care facility; health care personnel; health service; hospital patient; human; Korea; mortality; outpatient; prediction; recovery rate; root mean squared error; bioinformatics; biological model; epidemic; epidemiology; hand foot and mouth disease; South Korea; statistical model; Kalman filters ⓘ English 2025 2025-04 10.1371/journal.pcbi.1012996 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice ⓘ Introduction Prolonged viral infections often lead to lymphocyte exhaustion, marked by heightened inhibitory receptor expression like PD-1, compromising host defense mechanisms. The unexplored potential of chemical checkpoint inhibitors in rejuvenating immune responses prompted our investigation.Methods We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and Fc gamma RIIB expression in B cells.Results In this study, we harnessed a murine model of immune exhaustion induced by chronic hepatitis B virus (HBV) infection using hydrodynamic injection. Treatment with CCT007093 resulted in decreased levels of PD-1 expression, resulting in reduced percentages of PD-1+/hi CD4+ and CD8+ T cells in circulation, spleen, and liver. The expression levels of PD-1 and Fc gamma RIIB, along with the percentages of PD-1+/hi and Fc gamma RIIB+/hi CD19+ B cells in these tissues, were similarly diminished. Moreover, intrahepatic lymphocytes treated with CCT007093 displayed heightened responsiveness to ex vivo activation. Consequently, mice treated with CCT007093 exhibited significantly reduced serum HBsAg levels compared to vehicle-treated mice. Our detailed analyses, spanning promoter and transcriptome evaluations, uncovered p65 NF-kappa B as the primary activator of T cells and B cells, while Ying Yang 1 (YY1) emerged as the key regulator, orchestrating the down-regulation of PD-1 and Fc gamma RIIB gene transcription in response to CCT007093.Discussion Our study highlights the prowess of chemical checkpoint inhibitors, exemplified by CCT007093, in alleviating immune exhaustion in HBV-infected mice, particularly by enhancing adaptive immunity. ⓘ You, Yu-Syuan; Chang, Wan-Ting; Hsu, Chia-Lang; Wang, Hui-Ying; Lu, Yan-Fong; Kim, Inkyeom; Tzeng, Shiang-Jong ⓘ Natl Taiwan Univ, Grad Inst Pharmacol, Coll Med, Taipei, Taiwan; Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan; Shin Kong Wu Ho Su Mem Hosp, Dept Obstet & Gynecol, Taipei, Taiwan; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu, South Korea ⓘ Tzeng, Shiang-Jong/AED-3885-2022; Hsu, Chia-Lang/O-1458-2013 ⓘ 59912105900; 58764796300; 41561436100; 56901128000; 58764365600; 7404144630; 8061289500 ⓘ sjtzeng@ntu.edu.tw; ⓘ FRONTIERS IN IMMUNOLOGY ⓘ FRONT IMMUNOL ⓘ 1664-3224 16 SCIE IMMUNOLOGY ⓘ 2024 5.9 17.2 0 2025-06-11 ⓘ 0 0 CCT007093; p65 NF-kB; immune exhaustion; hepatitis B virus (HBV); Fc gamma RIIB; PD-1; wild-type p53-induced phosphatase (Wip1); Ying Yang 1 (YY1) ⓘ T-CELL DYSFUNCTION; BINDING; PD-1; PHOSPHATASE; EXPRESSION; CLEARANCE; RESPONSES; CANCER ⓘ CCT007093; FcγRIIB; hepatitis B virus (HBV); immune exhaustion; p65 NF-kB; PD-1; wild-type p53-induced phosphatase (Wip1); Ying Yang 1 (YY1) ⓘ Animals; B-Lymphocytes; Disease Models, Animal; Hepatitis B virus; Hepatitis B, Chronic; Immune System Exhaustion; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Receptors, IgG; Transcription Factor RelA; CD19 antigen; chemical agent; Fc IgG receptor IIB; gamma interferon; hepatitis B surface antigen; immunoglobulin enhancer binding protein P65; programmed death 1 receptor; protein; transcription factor YY1; transcriptome; unclassified drug; Wip1 inhibitor CCT007093; Fc receptor; programmed death 1 receptor; Rela protein, mouse; transcription factor RelA; adaptive immunity; animal cell; animal experiment; animal model; animal tissue; Article; B lymphocyte; bioinformatics; blood sampling; CD4+ T lymphocyte; CD8+ T lymphocyte; cell culture; chromatin immunoprecipitation; chronic hepatitis B; enzyme linked immunosorbent assay; enzyme linked immunospot assay; ex vivo study; flow cytometry; gene set enrichment analysis; HEK293T cell line; human; human cell; immune response; immune system exhaustion; Jurkat cell line; leukocyte; luciferase assay; lymphocyte; male; mouse; NF kB signaling; nonhuman; plasmid; protein expression; real time polymerase chain reaction; spleen cell; Western blotting; animal; C57BL mouse; disease model; drug effect; drug therapy; Hepatitis B virus; immune system exhaustion; immunology; metabolism ⓘ English 2025 2025-05-09 10.3389/fimmu.2025.1548814 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Adhesion and volume filling in one-dimensional population dynamics under no-flux boundary condition ⓘ We study the (generalized) one-dimensional population model developed by Anguige and Schmeiser [J. Math. Biol. 58 (3) (2009), 395-427], which reflects cell-cell adhesion and volume filling under no-flux boundary condition. In this generalized model, depending on the adhesion and volume filling parameters alpha,beta is an element of[0,1]$\alpha,\beta \in [0,1]$, the resulting equation is classified into six types. Among these, we focus on the type exhibiting strong effects of both adhesion and volume filling, which results in a class of advection-diffusion equations of the forward-backward-forward type. For five distinct cases of initial maximum, minimum, and average population densities, we derive the corresponding patterns for the global behavior of weak solutions to the initial and no-flux boundary value problem. Due to the presence of a negative diffusion regime, we indeed prove that the problem is ill-posed and admits infinitely many global-in-time weak solutions, with the exception of one specific case of the initial datum. This nonuniqueness is inherent in the method of convex integration that we use to solve the Dirichlet problem of a partial differential inclusion arising from the ill-posed problem. ⓘ Choi, Hyung Jun; Kim, Seonghak; Koh, Youngwoo ⓘ Korea Univ Technol & Educ, Sch Liberal Arts, Cheonan, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Kongju Natl Univ, Dept Math Educ, Kong Ju, South Korea ⓘ ⓘ 55780425800; 56489490600; 56729929100 ⓘ shkim17@knu.ac.kr; ⓘ JOURNAL OF THE LONDON MATHEMATICAL SOCIETY-SECOND SERIES ⓘ J LOND MATH SOC ⓘ 0024-6107 1469-7750 111 3 SCIE MATHEMATICS ⓘ 2024 1.2 17.3 0 2025-05-07 ⓘ 0 0 ⓘ PARABOLIC PROBLEM; AGGREGATION; CONVERGENCE ⓘ ⓘ ⓘ English 2025 2025-03 10.1112/jlms.70113 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Correction ⓘ c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer (vol 26, 13, 2024) ⓘ ⓘ Park, Jieun; Chang, Eun Sol; Kim, Ji-Yeon; Chelakkot, Chaithanya; Sung, Minjung; Song, Ji-Young; Jung, Kyungsoo; Lee, Ji Hye; Choi, Jun Young; Kim, Na Young; Lee, Hyegyeong; Kang, Mi-Ran; Kwon, Mi Jeong; Shin, Young Kee; Park, Yeon Hee; Choi, Yoon-La ⓘ Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul 08826, South Korea; Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Lab Mol Pathol & Theranost, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Irwon Ro 81, Seoul 06351, South Korea; Genobio Corp, Tech Res Ctr, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Lab Mol Pathol & Canc Genom, Seoul, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, Irwon Ro 81, Seoul 06351, South Korea; ABION Inc, R&D Ctr, Seoul, South Korea; LOGONE Bioconvergence Res Fdn, Cent Lab, Seoul, South Korea; Gencurix Inc, R&D Ctr, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr MRC, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Based Intelligent Novel Drug Discovery Educ Unit, BK21 FOUR Community, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea ⓘ Chelakkot, Chaithanya/KIB-3480-2024; Kim, Na-young/KHU-6533-2024 ⓘ 58067442600; 57221757103; 58384966700; 56285419800; 57192313172; 10242391100; 55973642900; 58820376700; 59441430300; 57218663203; 57201424559; 58820127100; 35278164800; 26428533000; 35273175600; 7404777529 ⓘ ykeeshin@snu.ac.kr; yhparkhmo@skku.edu; ylachoi@skku.edu; ⓘ BREAST CANCER RESEARCH ⓘ BREAST CANCER RES ⓘ 1465-5411 1465-542X 27 1 SCIE ONCOLOGY ⓘ 2024 5.6 17.3 0 2025-05-07 ⓘ 1 1 ⓘ ⓘ ⓘ clinical article; drug therapy; erratum; human; diagnosis; etiology; multiple cycle treatment ⓘ English 2025 2025-01-07 10.1186/s13058-024-01952-0 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Weighted shifts relevant to CPD matrices and their examples ⓘ In 1990 R. Curto introduced the notion of n-hyponormality which provides a bridge between subnormal and hyponormal operators. The study of n-hyponormal weighted shifts has been well developed by several mathematicians. In this paper we introduce a property CP(n) for weighted shifts related to (n + 1) x (n + 1) conditionally positive definite matrices, which generalizes n-hyponormality for weighted shifts. First the flatness of a weighted shift with properties CP (2) and CP (3) is considered, yielding a result which generalizes previous work. A formula for property CP(n) is constructed, which distinguishes the classes of weighted shifts with property CP(n). We introduce an algorithm to construct weighted shifts with property CP(n) and detect the structure related to property CP(n). Finally, we discuss property CP(n) of a homographic-type weighted shift with a constraint condition. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. ⓘ Exner, George R.; Jung, Il Bong; Lee, Eun Young; Lee, Mi Ryeong ⓘ Bucknell Univ, Dept Math, Lewisburg, PA 17837 USA; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Daegu Catholic Univ, Dept Math Educ, Gyeongsan, Gyongsan 38430, Gyeongbuk, South Korea ⓘ ⓘ 7004560697; 7102964485; 55371789400; 9637508200 ⓘ exner@bucknell.edu; ibjung@knu.ac.kr; eunyounglee@knu.ac.kr; leemr@cu.ac.kr; ⓘ JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS ⓘ J MATH ANAL APPL ⓘ 0022-247X 1096-0813 547 1 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2024 1.2 17.3 0 2025-05-07 ⓘ 0 0 Conditionally positive definite; matrix; operator; n-hyponormal operator; Weighted shift; Flatness; Homographic-type weighted shift ⓘ K-HYPONORMALITY; SUBNORMALITY ⓘ Conditionally positive definite matrix; Conditionally positive definite operator; Flatness; Homographic-type weighted shift; n-hyponormal operator; Weighted shift ⓘ ⓘ English 2025 2025-07-01 10.1016/j.jmaa.2025.129295 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A comparative study of nutrient compositions, phytochemicals, and antioxidant activities of two dehulled hemp seed cultivars harvested from different regions in the Republic of Korea ⓘ Hemp (Cannabis sativa L.) seeds are receiving considerable attention because of their potential applications in food industry. This study compared nutrient components and antioxidant activities of dehulled hemp seeds from 'Ordinary' and 'Cheongsam' varieties cultivated in various regions in the Republic of Korea to elucidate their potential for food applications. Results showed that dehulled hemp seeds were rich sources of protein, fat, mineral, and tocopherol contents, influenced significantly by both hemp genotype and environmental factors. Both 'Ordinary' and 'Cheongsam' dehulled hemp seeds possessed a favorable amino acid pattern, with high amounts of essential amino acids. Additionally, both cultivars exhibited high levels of unsaturated fatty acids, notably linoleic acid and alpha-linolenic acid, with a beneficial omega-6/omega-3 ratio for human health. Both cultivars possessed high levels of phenolic compounds and antioxidant capacities, especially cv. 'Cheongsam'. Overall, 'Cheongsam' hemp seeds exhibit exceptional nutrient components and antioxidant potential, showing promise in various food applications. ⓘ Hwang, Hee-Young; Truong, Van-Long; Jeong, Woo-Sik ⓘ Gyeongsangbuk Do Govt Publ Inst Hlth & Environm, Yeongcheon 38874, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea ⓘ Jeong, Woo-Sik/AAN-6885-2020 ⓘ 57217235580; 55925363400; 10440750200 ⓘ wsjeong@knu.ac.kr; ⓘ FOOD BIOSCIENCE ⓘ FOOD BIOSCI ⓘ 2212-4292 2212-4306 64 SCIE FOOD SCIENCE & TECHNOLOGY ⓘ 2024 5.9 17.4 3.26 2025-05-07 ⓘ 1 1 Cannabis sativa; Hemp seeds; 'Cheongsam' cultivar; 'Ordinary' cultivar; Nutrients; Antioxidant activity ⓘ ACID-COMPOSITION; FATTY-ACIDS; L.; OIL; PROTEIN; DELTA(9)-TETRAHYDROCANNABINOL; DIGESTIBILITY; TOCOPHEROLS; QUALITY ⓘ Antioxidant activity; Cannabis sativa; Hemp seeds; Nutrients; ‘Cheongsam’ cultivar; ‘Ordinary’ cultivar ⓘ ⓘ English 2025 2025-02 10.1016/j.fbio.2024.105752 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Aerodynamic Characteristics of a Tandem Flapping Wing in Inclined Stroke Plane Hovering with Ground Effect ⓘ The present two-dimensional study investigates the ground effect on the aerodynamic characteristics of a tandem flapping wing in inclined stroke plane hovering using ANSYS Fluent. The role of various wing kinematics parameters (flapping frequency f, stroke amplitude Ao/c, and phase difference psi = 0 degrees and 180 degrees), in combination with ground distance (D* = D/c), is studied. The results reveal that a large stroke amplitude Ao/c decreases vertical force generation for both in-phase and counter-stroking patterns. The vertical force notably increases for both in-phase and counter-stroking wings when D* is extremely small (D* = 0.5). A maximum vertical force enhancement of approximately 65% and 35% is observed for in-phase and counter-stroking patterns, respectively, at D* = 0.5. This enhancement is primarily attributed to the strengthening of detached vortices on the lower surface of the wings during the middle of the downstroke when flapping at extremely small ground distances. In addition, the wing-wing interaction and secondary rebound vortex, caused by wing-ground interaction, also play a key role in vertical force generation. The wing-ground interaction positively influences both vertical and thrust force generation for in-phase and counter-stroking wings at small ground distances. In general, the vertical and thrust forces generated by in-phase stroking wings are greater than those produced by counter-stroking wings. ⓘ Shanmugam, Arun Raj; Sohn, Chang Hyun; Park, Ki Sun ⓘ UAE Univ, Dept Mech & Aerosp Engn, Al Ain 15551, U Arab Emirates; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea ⓘ Park, Ki Sun/KEH-6331-2024 ⓘ 57209249478; 36806852600; 59969738000 ⓘ arunraj.v2009@gmail.com; chsohn@knu.ac.kr; kisunpark@uaeu.ac.ae; ⓘ BIOMIMETICS ⓘ BIOMIMETICS-BASEL ⓘ 2313-7673 10 4 SCIE ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 3.9 17.4 0 2025-05-07 ⓘ 0 0 aerodynamics; dragonflies; flapping wing; ground effect; hovering ⓘ 2-DIMENSIONAL MECHANISM; FLUID-DYNAMICS; FLIGHT; INSECT; MODEL; DRAG ⓘ aerodynamics; dragonflies; flapping wing; ground effect; hovering ⓘ Kinematics; Supersonic aircraft; Vortex flow; Aerodynamic characteristics; Dragonfly; Flapping-wing; Fluents; Force generation; Hovering; In-phase; Thrust forces; Two-dimensional; Vertical force; Aerodynamics ⓘ English 2025 2025-03-30 10.3390/biomimetics10040212 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Amelioration of muscle wasting by red algal protein: The preventive potential of Pyropia dentata protein In vitro and In vivo study ⓘ Muscle atrophy, characterized by decreased muscle mass, represents a significant health concern that can be addressed through dietary interventions when exercise is limited. This study investigates the potential of enzyme-assisted Pyropia dentata (PD) hydrolysate, an underutilized protein-rich red seaweed, in combating muscle atrophy. Among various enzymatic treatments, Foodpro (R) PNL enzyme-assisted and ethanol-precipitated PD (PDPE) demonstrated superior efficacy, exhibiting a 2.84-fold reduction in particle size and promoting significant muscle growth both in vitro and in zebrafish models. In dexamethasone-induced muscle atrophy, PDPE increased myotube diameter by 56.64 % and elevated average muscle fiber thickness in zebrafish by 15.13 %. Mechanistically, PDPE upregulated myogenesis factors (MyH by 2.1-fold) while downregulating muscle breakdown factors (MuRF1 by 4.2-fold). PDPE-treated zebrafish exhibited 35.11 % enhanced endurance and 32.22 % improved swimming speed, demonstrating functional benefits beyond cellular changes. Mass spectrometry analysis identified seven novel peptides in PDPE with high hydrophobic moments (up to 0.469), suggesting their contribution to the observed bioactivity. These findings establish PDPE as a promising biocompatible functional food ingredient for managing muscle weakness, while offering a sustainable alternative protein source for nutraceutical applications. ⓘ Hyun, Jimin; Kim, Gahyeon; Park, Surye; Kim, Jiyeon; Kim, Jae-Il; Ryu, Bomi ⓘ Pukyong Natl Univ, Major Food Sci & Nutr, Busan 48513, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea ⓘ ⓘ 57217067683; 59492722200; 59511565600; 59937678300; 56647575100; 35307815200 ⓘ localman@pknu.ac.kr; bmryu@pknu.ac.kr; ⓘ FOOD BIOSCIENCE ⓘ FOOD BIOSCI ⓘ 2212-4292 2212-4306 69 SCIE FOOD SCIENCE & TECHNOLOGY ⓘ 2024 5.9 17.4 N/A ⓘ 0 0 Seaweed; Pyropia dentata; Algal-protein; Nutraceuticals; Muscle atrophy; Zebrafish ⓘ HEALTH-BENEFITS; YEZOENSIS; BANGIALES; PEPTIDES ⓘ Algal-protein; Muscle atrophy; Nutraceuticals; Pyropia dentata; Seaweed; Zebrafish ⓘ ⓘ English 2025 2025-07 10.1016/j.fbio.2025.106902 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Design of a Wearable Exoskeleton Piano Practice Aid Based on Multi-Domain Mapping and Top-Down Process Model ⓘ This study designs and develops a wearable exoskeleton piano assistance system for individuals recovering from neurological injuries, aiming to help users regain the ability to perform complex tasks such as playing the piano. While soft robotic exoskeletons have proven effective in rehabilitation therapy and daily activity assistance, challenges remain in performing highly dexterous tasks due to structural complexity and insufficient motion accuracy. To address these issues, we developed a modular division method based on multi-domain mapping and a top-down process model. This method integrates the functional domain, structural domain, and user needs domain, and explores the principles and methods for creating functional construction modules, overcoming the limitations of traditional top-down approaches in design flexibility. By closely combining layout constraints with the design model, this method significantly improves the accuracy and efficiency of module configuration, offering a new path for the development of piano practice assistance devices. The results demonstrate that this device innovatively combines piano practice with rehabilitation training and through the introduction of ontological modeling methods, resolves the challenges of multidimensional needs mapping. Based on five user requirements (P), we calculated the corresponding demand weight (K), making the design more aligned with user needs. The device excels in enhancing motion accuracy, interactivity, and comfort, filling the gap in traditional piano assistance devices in terms of multi-functionality and high adaptability, and offering new ideas for the design and promotion of intelligent assistive devices. Simulation analysis, combined with the motion trajectory of the finger's proximal joint, calculates that 60 degrees is the maximum bending angle for the aforementioned joint. Physical validation confirms the device's superior performance in terms of reliability and high-precision motion reproduction, meeting the requirements for piano-assisted training. Through multi-domain mapping, the top-down process model, and modular design, this research effectively breaks through the design flexibility and functional adaptability bottleneck of traditional piano assistance devices while integrating neurological rehabilitation with music education, opening up a new application path for intelligent assistive devices in the fields of rehabilitation medicine and arts education, and providing a solution for cross-disciplinary technology fusion and innovative development. ⓘ Xu, Qiujian; Li, Meihui; Chen, Guoqiang; Ren, Xiubo; Yang, Dan; Li, Junrui; Yuan, Xinran; Liu, Siqi; Yang, Miaomiao; Chen, Mufan; Wang, Bo; Zhang, Peng; Ma, Huiguo ⓘ Yanshan Univ, Sch Arts & Design, Qinhuangdao 066000, Peoples R China; Daegu Catholic Univ, Mus Coll, YSU & DCU Joint Res Ctr Arts, Daegu 38430, South Korea; Yanshan Univ, Hebei Design Innovat & Ind Dev Res Ctr DIIDRC, Qinhuangdao 066000, Peoples R China; Kyungpook Natl Univ, Dept Design, Daegu 41566, South Korea; Quanzhou Ocean Inst, Sch Informat Engn, Quanzhou 362700, Peoples R China ⓘ ; Xu, Qiujian/F-9314-2011 ⓘ 58865240300; 58865462100; 55733505300; 58865240200; 58865312100; 58912946300; 58913271700; 58912785200; 59235482100; 59526977000; 59520524500; 58247542600; 59450794000 ⓘ xuqiujian@ysu.edu.cn; 18686969513@163.com; cgq9691@ysu.edu.cn; xiuboren@gmail.com; yangdan6413@163.com; lijunrui_1023@163.com; yuanxinran0112@163.com; liusiqi19990919@163.com; yangmiaomiao07@163.com; chenmufan0921@163.com; kstg4568320@gmail.com; 2021327350@knu.ac.kr; zhwdrfcdaaerov@hotmail.com; ⓘ BIOMIMETICS ⓘ BIOMIMETICS-BASEL ⓘ 2313-7673 10 1 SCIE ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 3.9 17.4 3.17 2025-05-07 ⓘ 1 1 multi-domain mapping; layout solution; wearable exoskeleton; piano practice assistance device ⓘ PRODUCT; ARCHITECTURE; INTEGRATION; EFFICIENCY ⓘ layout solution; multi-domain mapping; piano practice assistance device; wearable exoskeleton ⓘ ⓘ English 2025 2025-01 10.3390/biomimetics10010015 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Development and Evaluation of a Novel Upper-Limb Rehabilitation Device Integrating Piano Playing for Enhanced Motor Recovery ⓘ This study developed and evaluated a novel upper-limb rehabilitation device that integrates piano playing into task-oriented occupational therapy, addressing the limitations of traditional continuous passive motion (CPM) training in patient engagement and functional recovery. The system features a bi-axial sliding platform for precise 61-key positioning and a ten-link, four-loop robotic hand for key striking. A hierarchical control framework incorporates MIDI-based task mapping, finger optimization using an improved Hungarian algorithm, and impedance-admittance hybrid control for adaptive force-position modulation. An 8-week randomized controlled trial demonstrated that the experimental group significantly outperformed the control group, with a 74.7% increase in Fugl-Meyer scores (50.5 +/- 2.5), a 14.6-point improvement in the box and block test (BBT), a 20.2-s reduction in nine-hole peg test (NHPT) time, and a 72.6% increase in rehabilitation motivation scale (RMS) scores (55.4 +/- 3.8). The results indicate that combining piano playing with robotic rehabilitation enhances neuroplasticity and engagement, significantly improving motor function, daily activity performance, and rehabilitation adherence. This mechanical-control synergy introduces a new paradigm for music-interactive rehabilitation, with potential applications in home-based remote therapy and multimodal treatment integration. ⓘ Zhao, Xin; Zhang, Ying; Zhang, Yi; Zhang, Peng; Yu, Jinxu; Yuan, Shuai ⓘ Yanshan Univ, Sch Arts & Design, Qinhuangdao 066000, Peoples R China; Arts Dept Qinhuangdao Vocat & Tech Coll, Qinhuangdao 066100, Peoples R China; CPC Qinhuangdao Vocat & Tech Coll Comm, Org & Publ Off, Qinhuangdao 066100, Peoples R China; Kyungpook Natl Univ, Dept Design, Daegu 41566, South Korea; Ningbo Univ Technol, Coll Mech & Automot Engn Hangzhou Bay Automot Engn, Ningbo 315211, Peoples R China ⓘ ⓘ 59754551100; 59753463200; 59754725000; 58247542600; 56809701700; 59753649100 ⓘ cindy@ysu.edu.cn; zhangying@qvc.edu.cn; zhangyi@qvc.edu.cn; 2021327350@knu.ac.kr; jinxuyu@nbut.edu.cn; ys1217@ysu.edu.cn; ⓘ BIOMIMETICS ⓘ BIOMIMETICS-BASEL ⓘ 2313-7673 10 4 SCIE ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 3.9 17.4 0 2025-05-07 ⓘ 0 0 upper-limb rehabilitation device; task-oriented occupational therapy; music-interactive rehabilitation ⓘ STROKE REHABILITATION; BLOCK TEST; MUSIC; BOX ⓘ music-interactive rehabilitation; task-oriented occupational therapy; upper-limb rehabilitation device ⓘ Arthroplasty; Human rehabilitation equipment; Neuromuscular rehabilitation; Physical therapy; Robotic arms; Continuous passive motions; Functional recovery; Motor recovery; Music-interactive rehabilitation; Rehabilitation devices; System features; Task-oriented; Task-oriented occupational therapy; Upper-limb rehabilitation; Upper-limb rehabilitation device; Occupational therapy ⓘ English 2025 2025-03-25 10.3390/biomimetics10040200 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Development of a Bayesian Network-Based Parallel Mechanism for Lower Limb Gait Rehabilitation ⓘ This study aims to address the clinical needs of hemiplegic and stroke patients with lower limb motor impairments, including gait abnormalities, muscle weakness, and loss of motor coordination during rehabilitation. To achieve this, it proposes an innovative design method for a lower limb rehabilitation training system based on Bayesian networks and parallel mechanisms. A Bayesian network model is constructed based on expert knowledge and structural mechanics analysis, considering key factors such as rehabilitation scenarios, motion trajectory deviations, and rehabilitation goals. By utilizing the motion characteristics of parallel mechanisms, we designed a rehabilitation training device that supports multidimensional gait correction. A three-dimensional digital model is developed, and multi-posture ergonomic simulations are conducted. The study focuses on quantitatively assessing the kinematic characteristics of the hip, knee, and ankle joints while wearing the device, establishing a comprehensive evaluation system that includes range of motion (ROM), dynamic load, and optimization matching of motion trajectories. Kinematic analysis verifies that the structural design of the device is reasonable, aiding in improving patients' gait, enhancing strength, and restoring flexibility. The Bayesian network model achieves personalized rehabilitation goal optimization through dynamic probability updates. The design of parallel mechanisms significantly expands the range of joint motion, such as enhancing hip sagittal plane mobility and reducing dynamic load, thereby validating the notable optimization effect of parallel mechanisms on gait rehabilitation. ⓘ Ma, Huiguo; Bao, Yuqi; Jia, Chao; Chen, Guoqiang; Lan, Jingfu; Shi, Mingxi; Li, He; Guo, Qihan; Guan, Lei; Li, Shuang; Zhang, Peng ⓘ Quanzhou Ocean Inst, Sch Informat Engn, Quanzhou 362700, Peoples R China; Yanshan Univ, Sch Arts & Design, Qinhuangdao 066000, Peoples R China; Kyungpook Natl Univ, Dept Design, Daegu 41566, South Korea; Wuhan Univ Technol, Sch Art & Design, Wuhan 430070, Peoples R China; Datang Int Power Generat Co Ltd, Zhangjiakou Power Generat Branch, Zhangjiakou 075000, Peoples R China ⓘ ⓘ 59450794000; 59753837500; 59753837600; 55733505300; 59754730100; 59170301700; 59753837700; 59170865600; 59754730200; 59754379600; 58247542600 ⓘ zhwdrfcdaaerov@hotmail.com; baoyuqi001@hotmail.com; jiachao119@hotmail.com; cgq9691@ysu.edu.cn; lanjingfu001@hotmail.com; smx0609@knu.ac.kr; tayon13@sina.com; 349256@whut.edu.cn; 15230605261@163.com; 2021327350@knu.ac.kr; ⓘ BIOMIMETICS ⓘ BIOMIMETICS-BASEL ⓘ 2313-7673 10 4 SCIE ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 3.9 17.4 0 2025-05-07 ⓘ 0 0 lower limb rehabilitation training system; Bayesian network modeling; parallel mechanism control; kinematic analysis ⓘ ⓘ Bayesian network modeling; kinematic analysis; lower limb rehabilitation training system; parallel mechanism control ⓘ Design for testability; Gait analysis; Human rehabilitation equipment; Hydraulic structures; Integrated circuit design; Joints (anatomy); Machine design; Neuromuscular rehabilitation; Reconstruction (structural); Structural analysis; Structural dynamics; Bayesian network models; Kinematic Analysis; Limb rehabilitation; Low limb rehabilitation training system; Lower limb; Mechanism control; Parallel mechanism control; Parallel mechanisms; Rehabilitation training; Training Systems; Dynamic loads ⓘ English 2025 2025-04-08 10.3390/biomimetics10040230 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Economic Impacts of Ultrasonographic Fetal Sex Determination on Hanwoo Cattle Profitability and Market Dynamics ⓘ (1) Background: The Hanwoo cattle industry, valued for its premium beef, faces economic challenges due to fluctuating market prices, rising production costs, and profitability disparities based on calf sex, with male calves fetching higher prices and creating income imbalances for breeding farms. (2) Methods: This study assessed the economic impact of ultrasonographic fetal sex determination, a technology enabling fetal sex identification between 55 and 100 days of gestation, using 107 pregnant Hanwoo cows, of which 104 were successfully assessed with a 96.1% accuracy rate across all gestational stages. (3) Results: Economic analysis revealed that farms employing this technology achieved higher profitability by adjusting prices based on calf sex, with male calves significantly enhancing asset value; however, the technology's financial benefits were influenced by market dynamics, implementation costs, and sex ratios. (4) Conclusions: These findings underscore the potential of ultrasonographic fetal sex determination to improve Hanwoo farm profitability and sustainability, provided its adoption is accompanied by careful consideration of costs and market conditions. ⓘ Kim, Doyoon; Son, Miyeon; Jung, Daejin; Heo, Seongeun; Kim, Myoungok; Yi, Junkoo ⓘ Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Gyeongsangbukdo Livestock Res Inst, Yeongju 36052, South Korea; Purdue Univ, Dept Agr Econ, W Lafayette, IN 47907 USA; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Hankyong Natl Univ, Gyeonggi Reg Res Ctr, Anseong 17579, South Korea ⓘ ⓘ 57223194600; 59712964800; 57221405619; 59712964900; 8934745900; 56182537200 ⓘ kdy51311@korea.kr; son89@purdue.edu; djhoop@korea.kr; hse7451@korea.kr; ok4325@knu.ac.kr; junkoo@hknu.ac.kr; ⓘ VETERINARY SCIENCES ⓘ VET SCI ⓘ 2306-7381 12 3 SCIE VETERINARY SCIENCES ⓘ 2024 2.3 17.4 0 2025-05-07 ⓘ 0 0 breeding profitability; economic analysis; fetal sex determination; Hanwoo; ultrasonography ⓘ IN-SITU HYBRIDIZATION; GENDER DETERMINATION; FRACTIONS RICH; DAIRY-CATTLE; BOVINE; MANAGEMENT; ULTRASOUND; EMBRYOS ⓘ breeding profitability; economic analysis; fetal sex determination; Hanwoo; ultrasonography ⓘ agricultural land; agricultural worker; article; bovine; breeding; cost control; drug analysis; dynamics; echography; male; market; nonhuman; pharmacoeconomics; sex; sex determination ⓘ English 2025 2025-02-27 10.3390/vetsci12030201 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Feasibility of using cellulose nanofibers as a cryoprotectant for freeze-drying Bifidobacterium animalis subsp. lactis IDCC 4301 ⓘ Cryoprotectants are essential in probiotic product manufacturing, ensuring osmotic pressure balance and minimizing mechanical damage caused by ice crystals formation during freeze-drying. However, conventional cryoprotectants, such as sugar-based compounds, are typically required at concentrations exceeding 5 %, which may introduce formulation challenges. In this study, cellulose nanofibers (CNFs), one of the most abundant and sustainable biomaterials, were investigated for their potential as a low-concentration cryoprotectant. To assess their effectiveness, freeze-dried Bifidobacterium animalis subsp. lactis IDCC 4301 was subjected to different concentrations of CNFs with subsequent evaluation of bacterial growth and survival. Based on the comparison with trehalose, skim milk, and glycerol as a control, 0.05 % CNF was selected as the optimal cryoprotectant. Notably, B. animalis IDCC 4301 preserved with 0.05 % CNF exhibited comparable or superior survival rates under acid and bile conditions, as well as enhanced adhesion to gut epithelial cells relative to 0.05 % trehalose. In addition, during freeze-thaw cycles, CNF-treated B. animalis IDCC 4301 demonstrated higher viability with comparable metabolic activity, suggesting that CNFs effectively mitigate cellular damage by forming a viscous, flexible protective layer. These findings highlight the potential of CNFs as an innovative and efficient cryoprotectant, providing effective bacterial preservation at lower concentrations than traditional usage. Given their abundance, biocompatibility, and functionality, CNFs represent a promising alternative for improving probiotic stability in food applications. ⓘ Jeon, Hyeon Ji; Park, Bo Yeong; Shin, Gyu Ri; Lee, Jae Won; Shin, Minhye; Lee, Ju-Hoon; Kim, Younghoon; Kim, Byung Eui; Yang, Jungwoo; Jung, Young Hoon ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Sungshin Womens Univ, Dept Biotechnol, Seoul 01133, South Korea; Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Food & Anim Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea; Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea; Natl Jewish Hlth, Dept Pediat, Denver, CO USA; Dongguk Univ, Coll Med, Dept Microbiol, Gyeongju 38066, South Korea ⓘ Jeon, Hyeon Ji/HPH-4892-2023; Jung, Young Hoon/F-1703-2013; Jung, Young/F-1703-2013 ⓘ 57795638700; 59716881900; 58845116200; 59255119200; 57208401604; 54975259000; 41761886700; 15839361000; 56076383700; 55550063700 ⓘ dbl3jwy@dongguk.ac.kr; younghoonjung@knu.ac.kr; ⓘ FOOD BIOSCIENCE ⓘ FOOD BIOSCI ⓘ 2212-4292 2212-4306 68 SCIE FOOD SCIENCE & TECHNOLOGY ⓘ 2024 5.9 17.4 0 2025-05-07 ⓘ 0 0 Cellulose nanofibers; Cryoprotectant; Probiotics; Freeze-drying ⓘ VIABILITY; SURVIVAL; PROBIOTICS; OPTIMIZATION; STABILITY; ENHANCE; IMPACT; ICE ⓘ Cellulose nanofibers; Cryoprotectant; Freeze-drying; Probiotics ⓘ ⓘ English 2025 2025-06 10.1016/j.fbio.2025.106481 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Flash Memory for Synaptic Plasticity in Neuromorphic Computing: A Review ⓘ The rapid expansion of data has made global access easier, but it also demands increasing amounts of energy for data storage and processing. In response, neuromorphic electronics, inspired by the functionality of biological neurons and synapses, have emerged as a growing area of research. These devices enable in-memory computing, helping to overcome the "von Neumann bottleneck", a limitation caused by the separation of memory and processing units in traditional von Neumann architecture. By leveraging multi-bit non-volatility, biologically inspired features, and Ohm's law, synaptic devices show great potential for reducing energy consumption in multiplication and accumulation operations. Within the various non-volatile memory technologies available, flash memory stands out as a highly competitive option for storing large volumes of data. This review highlights recent advancements in neuromorphic computing that utilize NOR, AND, and NAND flash memory. This review also delves into the array architecture, operational methods, and electrical properties of NOR, AND, and NAND flash memory, emphasizing its application in different neural network designs. By providing a detailed overview of flash memory-based neuromorphic computing, this review offers valuable insights into optimizing its use across diverse applications. ⓘ Im, Jisung; Pak, Sangyeon; Woo, Sung-Yun; Shin, Wonjun; Lee, Sung-Tae ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Hongik Univ, Sch Elect & Elect Engn, Seoul 04066, South Korea; Sungkyunkwan Univ, Dept Semicond Convergence Engn, Suwon 16419, South Korea ⓘ Pak, Sangyeon/K-6638-2018; Pak, Sangyeon/AHE-6721-2022 ⓘ 59325078500; 57189709113; 57201527826; 57210823123; 57203597778 ⓘ wltjd7055@naver.com; spak@hongik.ac.kr; sywoo@knu.ac.kr; swj0107@skku.edu; lst777@hongik.ac.kr; ⓘ BIOMIMETICS ⓘ BIOMIMETICS-BASEL ⓘ 2313-7673 10 2 SCIE ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 3.9 17.4 0 2025-05-07 ⓘ 0 0 neuromorphic; synaptic device; in-memory computing; NOR flash memory; AND flash memory; NAND flash memory; flash memory ⓘ IN-MEMORY; HIGH-DENSITY; NEURAL-NETWORKS; ULTRA-EFFICIENT; HIGH-PRECISION; SRAM MACRO; TFT-TYPE; ARCHITECTURE; ROBUST; RRAM ⓘ AND flash memory; flash memory; in-memory computing; NAND flash memory; neuromorphic; NOR flash memory; synaptic device ⓘ ⓘ English 2025 2025-02 10.3390/biomimetics10020121 ⓘ 바로가기 바로가기 바로가기 바로가기
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