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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Effect of neoadjuvant chemotherapy on breast tissue composition: a longitudinal mammographic study with automated volumetric measurement ⓘ Objectives To investigate the effect of neoadjuvant chemotherapy (NAC) on breast tissue composition with mammographic automated volumetric measurement. Methods This retrospective study included 168 breast cancer patients who were treated with NAC and underwent serial mammography (pre-treatment, mid-treatment, and post-treatment) between January 2015 and October 2018. Automated volumetric measurements of the contralateral breast volume (BV), fibroglandular volume (FGV), and breast density (BD) were performed using Volpara software. BD grades were divided into 4 groups by Volpara density grade (VDG). The longitudinal changes in BV, FGV, BD, and their associated factors were evaluated. Results Repeated-measures analysis of variance demonstrated a significant reduction in BV, FGV, and BD over time (p < 0.001, p < 0.001, and p = 0.002, respectively). BV showed a greater reduction in the second half than in the first half (- 28.6 cm(3) vs. - 15.2 cm(3)), BD showed a greater reduction in the first half than in the second half (- 0.8% vs. - 0.1%), and FGV steadily decreased (- 4.6 cm(3) and - 3.9 cm(3) in the first and second halves). On multivariable linear regression analysis, chemotherapy regimen was associated with BV change between pre- and post-treatment (p = 0.002); age (p = 0.024) and VDG (p = 0.027) were associated with FGV change; age (p = 0.037), VDG (p = 0.002), and chemotherapy regimen (p = 0.003) were associated with BD change. Conclusions NAC affects breast tissue composition, reflected as reductions in BV, FGV, and BD. Mammography with automated volumetric measurement can capture quantitative changes in these breast tissue parameters during NAC. ⓘ Jang, Hyeon Jun; Kim, Hye Jung; Chae, Yee Soo; Lee, Soo Jung; Kim, See Hyung; Lee, Hoseok; Kim, Won Hwa ⓘ Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea ⓘ Kim, Sang-Hyun/J-5402-2012 ⓘ 57216510587; 57203506201; 57190793908; 57203597252; 57216511386; 57200653487; 36081886500 ⓘ greenoaktree9@gmail.com; ⓘ EUROPEAN RADIOLOGY ⓘ EUR RADIOL ⓘ 0938-7994 1432-1084 30 9 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ⓘ 2020 5.315 16.2 0.35 2025-06-25 ⓘ 6 5 Mammography; Neoadjuvant therapy; Breast density ⓘ CONTRALATERAL NORMAL BREAST; DENSITY; AMENORRHEA; REDUCTION; ESTROGEN; THERAPY; RISK ⓘ Breast density; Mammography; Neoadjuvant therapy ⓘ Adult; Aged; Breast; Breast Density; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Longitudinal Studies; Mammography; Middle Aged; Neoadjuvant Therapy; Organ Size; Regression Analysis; Retrospective Studies; Software; carboplatin; cyclophosphamide; docetaxel; doxorubicin; epidermal growth factor receptor 2; estrogen receptor; pertuzumab; progesterone receptor; trastuzumab; adult; aged; analysis of variance; Article; automated volumetric measurement; breast cancer; breast density; breast tissue; breast volume; cancer combination chemotherapy; controlled study; estrogen receptor positive breast cancer; fibroglandular volume; histopathology; human; human epidermal growth factor receptor 2 positive breast cancer; image analysis; in situ hybridization; longitudinal study; major clinical study; mammography; multiple cycle treatment; neoadjuvant chemotherapy; priority journal; progesterone receptor positive breast cancer; retrospective study; treatment duration; adjuvant chemotherapy; breast; breast tumor; diagnostic imaging; drug effect; female; mammography; middle aged; neoadjuvant therapy; organ size; regression analysis; software ⓘ English 2020 2020-09 10.1007/s00330-020-06830-9 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular therapy ⓘ Objectives This study aimed to investigate infarct growth patterns in stroke patients with large vessel occlusion (LVO) and successful recanalization by endovascular therapy (EVT). Methods A total of 135 patients with LVO of the internal carotid artery or proximal segment of the middle cerebral artery admitted within 12 h after onset, having baseline National Institute of Health Stroke Scale score >= 5 points, and successfully recanalized by EVT were enrolled. Infarct growth pattern models were developed based on infarct volumes on diffusion-weighted imaging before and after reperfusion. Single pattern models of linear, logarithmic, and exponential shapes were initially tested. Their appropriateness was predetermined. If none of these patterns was suitable, the best pattern model, which was the most suitable pattern among the three shapes selected for each individual, was tested. Clinical correlates were explored. Results Each single pattern model was tested for their suitability. However, none of the single pattern models successfully represented infarct growth curves: Of all subjects, only 63.7%, 62.2%, and 54.1% of patients were explained by the logarithmic, linear, and exponential model, respectively. Compared with the single pattern models, the best pattern model explained 80.7% of the subjects. The linear shape fit best in 40 patients, the logarithmic in 51, and the exponential in 44. Those fit best for the logarithmic pattern showed more favorable outcomes at discharge (31.4%) than did the others (linear, 10.0%; exponential, 9.1%;p = 0.01). Conclusions Infarct growth patterns may vary among individual patients with acute stroke due to LVO and successful treatment with EVT. ⓘ Gwak, Dong-Seok; Park, Hong-Kyun; Jung, Cheolkyu; Kim, Jae Hyoung; Lee, Juneyoung; Kim, Beom Joon; Han, Moon-Ku; Bae, Hee-Joon ⓘ Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Inje Univ, Coll Med, Dept Neurol, Ilsan Paik Hosp, Goyang, South Korea; Seoul Natl Univ, Coll Med, Dept Radiol, Bundang Hosp, Seongnam, South Korea; Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Neurol, 82 Gumi Ro 173 Beon Gil, Seongnam Si 13620, Gyeonggi Do, South Korea ⓘ LEE, HYUN/D-6482-2016; Kim, Beom Joon/C-2904-2011; Han, Moon-Ku/J-5703-2012 ⓘ 57205148053; 58205849100; 15136364700; 8694173200; 34667876400; 56415337700; 35361858400; 7103223963 ⓘ braindoc@snu.ac.kr; ⓘ EUROPEAN RADIOLOGY ⓘ EUR RADIOL ⓘ 0938-7994 1432-1084 30 12 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ⓘ 2020 5.315 16.2 0.52 2025-06-25 ⓘ 9 10 Cerebral infarction; Diffusion; Thrombectomy; Stroke ⓘ FOCAL CEREBRAL-ISCHEMIA; PERFUSION; BRAIN; TIME; MRI ⓘ Cerebral infarction; Diffusion; Stroke; Thrombectomy ⓘ Aged; Arterial Occlusive Diseases; Brain Infarction; Carotid Artery, Internal; Databases, Factual; Diffusion Magnetic Resonance Imaging; Endovascular Procedures; Female; Humans; Male; Middle Cerebral Artery; Prospective Studies; Registries; Republic of Korea; Stroke; Treatment Outcome; tissue plasminogen activator; aged; angioplasty; Article; brain infarction size; brain ischemia; controlled study; diffusion weighted imaging; endovascular surgery; female; follow up; human; infarct volume; internal carotid artery occlusion; major clinical study; male; mechanical thrombectomy; middle cerebral artery occlusion; National Institutes of Health Stroke Scale; priority journal; prospective study; recanalization; reperfusion; stroke patient; brain infarction; cerebrovascular accident; complication; diagnostic imaging; endovascular surgery; factual database; internal carotid artery; middle cerebral artery; peripheral occlusive artery disease; procedures; register; South Korea; treatment outcome ⓘ English 2020 2020-12 10.1007/s00330-020-07068-1 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Interface engineering of ultrathin multi-functional 2D draped chitosan for efficient charge separation on degradation of paraquat - A mechanistic study ⓘ In the present study, graphene oxide (GO) and reduced graphene oxide (rGO) draped chitosan (CS) was synthesized via simple co-precipitation method. Paraquat (PQT), a non-selective contact herbicide which is used to control weeds and algae. It causes critic problems to living organisms due to occur of pesticides on drinking water. Under visible light irradiation, CS/rGO was able to degrade 85.49 % of PQT solution within 60 min, and this ability remained 82 % was accomplished after 5 repetitive use at the same conditions. Whereas, CS/GO has ameliorated results as compared to CS/rGO. The kinetics and rate of reaction were follows the pseudo-first order kinetics towards catalytic degradation of PQT. In this study, CS/GO and CS/rGO photocatalyst were prepared and the materials have been characterized using FTIR, XRD, SEM-EDX, TEM, TGA-DSC, BET, DLS, and zeta potential etc., and identification of by-products using LC-MS technique. The above results suggests that the prepared materials employed as affable substitute for the remediation of organophosphate pesticides in aqueous solution. ⓘ Vigneshwaran, Sivakumar; Preethi, Jayaram; Meenakshi, Sankaran ⓘ Gandhigram Rural Inst Deemed Univ, Dept Chem, Dindigul 624302, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Vigneshwaran, Siva kumar/IST-9536-2023; Vigneshwaran, Sivakumar/AAE-6278-2022; Meenakshi, Sankaran/AAF-5748-2020 ⓘ 57207105576; 58909614400; 58099005900 ⓘ vigneshwarangri@gmail.com;jpreethigri@gmail.com;sankaranmeenakshi2014@gmail.com; ⓘ JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING ⓘ J ENVIRON CHEM ENG ⓘ 2213-2929 2213-3437 8 5 SCIE ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL ⓘ 2020 5.909 16.4 0.41 2025-06-25 ⓘ 9 10 Reduced graphene oxide; Chitosan; CS/rGO; Paraquat dichloride; Degradation; Pathway ⓘ PHOTOCATALYTIC DEGRADATION; VISIBLE-LIGHT; GRAPHENE OXIDE; RHODAMINE-B; BISPHENOL-A; TIO2; MINERALIZATION; COMPOSITES; PESTICIDES; HERBICIDE ⓘ Chitosan; CS/rGO; Degradation; Paraquat dichloride; Pathway; Reduced graphene oxide ⓘ Biology; Chitosan; Graphene; Herbicides; Potable water; Precipitation (chemical); Reaction kinetics; Reduced Graphene Oxide; Catalytic degradation; Coprecipitation method; Interface engineering; Mechanistic studies; Organophosphate pesticides; Pseudo first-order kinetics; Reduced graphene oxides (RGO); Visible-light irradiation; Photodegradation ⓘ English 2020 2020-10 10.1016/j.jece.2020.104446 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Pollen records of orbitally modulated variation in East Asian winter monsoon intensity and freshwater inflow to the Ulleung Basin of East Sea, South Korea, during the last glacial period ⓘ Most pollen analysis in Korea has focused on the Holocene Epoch, because pre-last glacial maximum terrestrial archives suitable for palynological study in the Korean Peninsula are limited. Thus, to verify the responses of vegetation to climate changes over the orbital timescales, analysis of pollen in marine sediments is needed. Here, we present the pollen record of hemipelagic sediments of core DD09-ST21 obtained from the northern Ulleung Basin in the East Sea. The palynofloral assemblages were dominated by warm temperate broadleaved trees and boreal conifers during interglacial and glacial periods, respectively. We also demonstrated that bisaccate pollen and herbaceous pollen in the palynological sequence can be used as indicators of the variation in the East Asian winter monsoon (EAWM) intensity during the last glacial period and freshwater inflow into the East Sea, respectively. During glacial periods, the EAWM intensified in response to weakening of the summer insolation at 60 degrees N, while freshwater influx into the East Sea decreased due to a decrease in precipitation. ⓘ Jun, Chang-Pyo; Yi, Sangheon; Kim, Chang-Hwan; Park, Chan Hong; Lee, Seong-Joo ⓘ Korea Inst Geosci & Mineral Resources, Daejeon 34132, South Korea; Korea Univ Sci & Technol UST, Daejeon 34132, South Korea; Korea Inst Ocean Sci & Technol, Uljin 36315, South Korea; Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea ⓘ YI, Sangheon/D-4780-2011; Yi, Sangheon/D-4780-2011 ⓘ 36655926700; 7201404844; 55697749400; 55851597700; 48961279800 ⓘ shyi@kigam.re.kr; ⓘ MARINE GEOLOGY ⓘ MAR GEOL ⓘ 0025-3227 1872-6151 430 SCIE GEOSCIENCES, MULTIDISCIPLINARY;OCEANOGRAPHY ⓘ 2020 3.548 16.4 0.51 2025-06-25 ⓘ 9 9 Climate oscillation; Vegetation change; Boreal conifer pollen; Herbs pollen; Late Quaternary ⓘ EOLIAN QUARTZ FLUX; JAPAN SEA; PALEOENVIRONMENTAL CHANGES; MARINE-SEDIMENTS; JEJU ISLAND; LAKE BIWA; CHINA SEA; CHEMICAL CLASSIFICATION; ENVIRONMENTAL-CHANGES; VEGETATION CHANGES ⓘ Boreal conifer pollen; Climate oscillation; Herbs pollen; Late Quaternary; Vegetation change ⓘ Korea; Pacific Ocean; Sea of Japan; Ulleung Basin; Coniferophyta; Atmospheric thermodynamics; Climate change; Forestry; Salinity measurement; Submarine geology; Water; Broadleaved trees; East Asian winter monsoon; Freshwater inflow; Freshwater influx; Hemipelagic sediments; Last Glacial Maximum; Last glacial period; Marine sediments; herb; Holocene; insolation; interglacial; Last Glacial; marine sediment; monsoon; palynology; pollen; Glacial geology ⓘ English 2020 2020-12 10.1016/j.margeo.2020.106365 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Association of Self-Leadership and Planning With Performing an Exercise in Patients With Colorectal Cancer Cross-Sectional Study ⓘ Background A healthy lifestyle that includes physical activity is an essential component of the care plans for cancer survivors. However, many cancer survivors remain inactive, even if they feel motivated to exercise. Based on the Chronic Care Model, self-leadership and planning may improve cancer survivors' self-management of their own care. Objective The aim of this study was to examine whether self-leadership skills and planning are associated with performance and maintenance of an exercise program in patients with colorectal cancer. Methods This cross-sectional study enrolled 251 consecutive patients with colorectal cancer who received primary curative surgery and were undergoing or had completed other therapy at the National University Hospitals from 2 regions in South Korea. Demographic data and measures of self-leadership and planning were obtained from questionnaires and clinical data from hospital databases. Self-leadership was measured using the validated Abbreviated Self-Leadership Questionnaire, and another validated psychometric assessment instrument was used to measure "action planning" and "coping planning." Results Performing and maintaining an exercise program at a level recommended by an American Cancer Society panel correlated with greater self-leadership of behavior awareness and volition, task motivation, and constructive cognition. Greater action planning was associated with performing and maintaining this exercise program for more than 6 months. Conclusions The results of the current study indicate that having self-leadership and action planning are significantly associated with performing and maintaining an exercise program. ⓘ Lee, Myung Kyung; Park, Soo Yeun; Choi, Gyu-Seog ⓘ Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, 807 Hogukro, Daegu 41407, South Korea ⓘ ⓘ 40661513200; 40561578300; 8058759100 ⓘ psy-flower@hanmail.net; ⓘ CANCER NURSING ⓘ CANCER NURS ⓘ 0162-220X 1538-9804 43 1 SCIE;SSCI NURSING;ONCOLOGY ⓘ 2020 2.592 16.5 0.52 2025-06-25 ⓘ 7 7 colorectal neoplasms; exercise; health planning support; self-leadership ⓘ QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; MANAGEMENT; INTERVENTION; SURVIVORS; DIET; STATISTICS; INTENTIONS; DIAGNOSIS ⓘ colorectal neoplasms; exercise; health planning support; self-leadership ⓘ Adult; Cancer Survivors; Colorectal Neoplasms; Cross-Sectional Studies; Exercise; Female; Humans; Leadership; Male; Middle Aged; Motivation; Republic of Korea; Self-Management; Surveys and Questionnaires; adult; aerobic exercise; Article; awareness; cancer surgery; colorectal cancer; cross-sectional study; exercise; female; human; leadership; major clinical study; male; middle aged; motivation; non profit organization; physical activity; priority journal; psychometry; self care; skill; South Korea; university hospital; cancer survivor; colorectal tumor; exercise; psychology; questionnaire; self care ⓘ English 2020 2020 (JAN-FEB) 10.1097/ncc.0000000000000673 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Introduction of Interfacial Load Polymeric Layer to Organic Flexible Memristor for Regulating Conductive Filament Growth ⓘ In flexible neuromorphic electronics, solution-processed organic memristors are important elements to perform memory functions. Despite considerable development for improving performances of organic memristors, the devices still exhibit the poor reliability and uniformity due to the stochastic characteristics of the conductive filament (CF) growth. Herein, the effective concept of introducing the interfacial load polymer (ILP) layers that control the CF growth in flexible organic memristors is demonstrated. In the flexible organic memristor, the ILP serves as an internal load resistor that regulates the CF growth in the electrolyte medium and the electron blocking layer, hence realizing self-rectifying characteristics. In particular, the ILP provides the self-compliance current of the device, which delicately limits the overgrowth of CFs. The flexible device delivers higher electrical performance (better reliability, uniformity, and the switching currents) than conventional devices without the ILP. Moreover, the device operates stably under repeated bending-straightening deformations. This unprecedented concept of achieving the capabilities of self-compliance current and self-rectifying property in a single memristor will provide a practical platform for constructing and realizing next-generation flexible neuromorphic systems. ⓘ Park, Hea-Lim; Kim, Min-Hoi; Lee, Sin-Hyung ⓘ Seoul Natl Univ, Dept Mat Sci & Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Hanbat Natl Univ, Dept Creat Convergence Engn, Daejeon 305719, South Korea; Kyungpook Natl Univ, Sch Elect Engn, 80 Daehak Ro, Daegu 702701, South Korea ⓘ ; Lee, Sin-Hyung/ABD-6425-2022 ⓘ 55735654600; 38260922200; 57226880204 ⓘ mhkim8@hanbat.ac.kr;sinhlee@knu.ac.kr; ⓘ ADVANCED ELECTRONIC MATERIALS ⓘ ADV ELECTRON MATER ⓘ 2199-160X 6 10 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED ⓘ 2020 7.295 16.6 1.78 2025-06-25 ⓘ 45 39 conductive filament growth; device reliability; organic memristors; self-regulation ⓘ RESISTIVE SWITCHING CHARACTERISTICS; MEMORY; DEVICES; PERFORMANCE; MECHANISMS; UNIFORMITY; OXIDE ⓘ conductive filament growth; device reliability; organic memristors; self-regulation ⓘ Electrolytes; Memristors; Polymers; Stochastic systems; Conductive filaments; Electrical performance; Electron blocking layer; Improving performance; Neuromorphic systems; Rectifying characteristics; Rectifying properties; Stochastic characteristic; Flexible electronics ⓘ English 2020 2020-10 10.1002/aelm.202000582 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Protein Nanosphere Anchors for Stabilizing Hydroxylated Polymer Chains in Organic Memory Transistors with Outstanding Retention Characteristics ⓘ It is demonstrated that a heme protein (cytochrome c [Cyt c]) nanosphere plays a strong anchoring role in binding hydroxyl groups of poly(vinyl alcohol) (PVA) leading to outstanding high-temperature (100 degrees C) retention characteristics of transistor-type organic memory devices (TOMDs). The PVA:Cyt c layers are spin-coated on indium tin oxide gate electrodes from aqueous solutions with various Cyt c contents up to 50 wt%, followed by the formation of poly(3-hexylthiophene) (P3HT) channel layers and nickel/aluminum top source/drain electrodes in TOMDs. Results show that adding 20 wt% Cyt c improves the drain current of devices in the presence of good hysteresis characteristics, which are maintained even after exposure to high-temperature conditions (100 degrees C). The excellent conservation of hysteresis characteristics is attributed to the formation of Cyt c nanospheres that act as an anchoring point to retard the relaxation of PVA chains via specific interactions (hydrogen bonding etc.) between amino groups in the Cyt c nanosphere surfaces and hydroxyl groups in the PVA chains. The optimized PVA:Cyt c layers (20 wt% Cyt c, thermal treatment at 100 degrees C) deliver excellent retention characteristics to TOMDs, whereas no memory function is measured in the case of the pristine PVA layers at 100 degrees C. ⓘ Seo, Jooyeok; Kim, Hwajeong; Lee, Chulyeon; Kim, Youngkyoo ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, Organ Nanoelect Lab, KNU Inst Nanophoton Applicat KINPA,Dept Chem Engn, Daegu 41566, South Korea; Univ Oxford, Clarendon Lab, Dept Phys, Parks Rd, Oxford OX1 3PU, England; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, Prior Res Ctr, Daegu 41566, South Korea ⓘ ⓘ 55614739000; 15520531700; 56354831300; 10340424400 ⓘ ykimm@knu.ac.kr; ⓘ ADVANCED ELECTRONIC MATERIALS ⓘ ADV ELECTRON MATER ⓘ 2199-160X 6 3 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED ⓘ 2020 7.295 16.6 0.31 2025-06-25 ⓘ 5 4 Cyt c; hysteresis; organic memory transistors; protein nanospheres; PVA ⓘ CYTOCHROME-C; FLEXIBLE ELECTRONICS; NONVOLATILE MEMORY; HEME PROTEIN; ELECTRETS; BEHAVIOR; DEVICES ⓘ Cyt c; hysteresis; organic memory transistors; protein nanospheres; PVA ⓘ Carrier transport; Drain current; Electrodes; Hydrogen bonds; Hysteresis; Indium compounds; Polyvinyl alcohols; Proteins; Refractory metal compounds; Tin oxides; High temperature condition; Hysteresis characteristics; Organic memory; Organic memory devices; Poly (vinyl alcohol) (PVA); Protein Nanospheres; Retention characteristics; Source/drain electrodes; Nanospheres ⓘ English 2020 2020-03 10.1002/aelm.201900920 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice ⓘ Chronic alcohol feeding increases the levels of 2-arachidonoylglycerol (2-AG) in the liver, which activates hepatic cannabinoid receptor type 1 (CB1R), leading to oxidative liver injury. 2-AG biosynthesis is catalyzed by diacylglycerol lipase (DAGL). However, the mechanisms regulating hepatic DAGL gene expression and 2-AG production are largely unknown. In this study, we show that CB1R-induced estrogen-related receptor gamma (ERR gamma) controls hepatic DAGL gene expression and 2-AG levels. Arachidonyl-2 '-chloroethylamide (ACEA), a synthetic CB1R agonist, significantly upregulated ERR gamma, DAGL alpha, and DAGL beta, and increased 2-AG levels in the liver (10 mg/kg) and hepatocytes (10 mu M) of wild-type (WT) mice. ERR gamma overexpression upregulated DAGL alpha and DAGL beta expressions and increased 2-AG levels, whereas ERR gamma knockdown abolished ACEA-induced DAGL alpha, DAGL beta, and 2-AG in vitro and in vivo. Promoter assays showed that ERR gamma positively regulated DAGL alpha and DAGL beta transcription by binding to the ERR response element in the DAGL alpha and DAGL beta promoters. Chronic alcohol feeding (27.5% of total calories) induced hepatic steatosis and upregulated ERR gamma, leading to increased DAGL alpha, DAGL beta, or 2-AG in WT mice, whereas these alcohol-induced effects did not occur in hepatocyte-specific CB1R knockout mice or in those treated with the ERR gamma inverse agonist GSK5182 (40 mg/kg in mice and 10 mu M in vitro). Taken together, these results indicate that suppression of alcohol-induced DAGL alpha and DAGL beta gene expressions and 2-AG levels by an ERR gamma-specific inverse agonist may be a novel and attractive therapeutic approach for the treatment of alcoholic liver disease. ⓘ Jung, Yoon Seok; Kim, Yong-Noon; Radhakrishnan, Kamalakannan; Kim, Jina; Kim, Don-Kyu; Lee, Ji-Hyeok; Oh, Hyunhee; Lee, In-Kyu; Kim, Wook; Cho, Sung Jin; Choi, Cheol Soo; Dooley, Steven; Egan, Josephine M.; Lee, Chul-Ho; Choi, Hueng-Sik ⓘ Chonnam Natl Univ, Natl Creat Res Initiat Ctr Nucl Receptor Signals, Sch Biol Sci & Technol, Kwangju 61186, South Korea; Chonnam Natl Univ, Hormone Res Ctr, Sch Biol Sci & Technol, Kwangju 61186, South Korea; Korea Res Inst Biosci & Biotechnol, Lab Anim Resource Ctr, 125 Gwahak Ro, Taejon 34141, South Korea; Korea Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Taejon 34113, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Taegu 41061, South Korea; Gachon Univ, Korea Mouse Metab Phenotyping Ctr, Lee Gil Ya Canc & Diabet Inst, Incheon 21999, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Taegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Taegu 41404, South Korea; Ajou Univ, Dept Mol Sci & Technol, Suwon, South Korea; Gachon Univ, Gil Med Ctr, Endocrinol, Internal Med, Incheon 21565, South Korea; Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Mannheim, Germany; NIA, Lab Clin Invest, NIH, Baltimore, MD 21224 USA ⓘ Radhakrishnan, Kamalakannan/HNP-0477-2023; Lee, In-Kyu/AAR-6374-2021; Lee, Junseong/T-4139-2017; Lee, Chul-Ho/MBV-8603-2025; Jung, Yoon/B-8512-2011; Dooley, Steven/T-6491-2018 ⓘ 57203348590; 57210989406; 57217673988; 56949261900; 37081358700; 55511358800; 36461469800; 36071537600; 57201493662; 56949426900; 35285414100; 35402441200; 7202144917; 56223516500; 7404338771 ⓘ chullee@kribb.re.kr;hsc@chonnam.ac.kr; ⓘ ARCHIVES OF TOXICOLOGY ⓘ ARCH TOXICOL ⓘ 0340-5761 1432-0738 94 2 SCIE TOXICOLOGY ⓘ 2020 5.153 16.7 0.36 2025-06-25 ⓘ 7 8 2-AG; Hepatic CB1R; DAGL; Endocannabinoid; ERR gamma; GSK5182 ⓘ PHOSPHATIDIC-ACID PHOSPHATASE; NUCLEAR RECEPTOR; ERR-GAMMA; OXIDATIVE STRESS; BIOSYNTHESIS; ACTIVATION; ETHANOL; IDENTIFICATION; PATHOGENESIS; SELECTIVITY ⓘ 2-AG; DAGL; Endocannabinoid; ERRγ; GSK5182; Hepatic CB1R ⓘ Animals; Arachidonic Acids; Endocannabinoids; Ethanol; Gene Expression Regulation; Glycerides; Hep G2 Cells; Hepatocytes; Humans; Lipoprotein Lipase; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Receptor, Cannabinoid, CB1; Receptors, Estrogen; Tamoxifen; 2 arachidonoylglycerol; alcohol; arachidonyl 2' chloroethylamide; cannabinoid 1 receptor; cannabinoid 1 receptor agonist; diacylglycerol lipase alpha; diacylglycerol lipase beta; estrogen related receptor gamma; gsk 5182; hormone receptor stimulating agent; lipoprotein lipase; messenger RNA; steroid receptor; unclassified drug; acylglycerol; alcohol; arachidonic acid derivative; arachidonyl-2-chloroethylamide; cannabinoid 1 receptor; CNR1 protein, mouse; diacylglycerol lipase alpha, human; diacylglycerol lipase beta, mouse; endocannabinoid; Esrrg protein, mouse; estrogen receptor; glyceryl 2-arachidonate; GSK5182; lipoprotein lipase; tamoxifen; alcohol consumption; alcohol intoxication; alcohol liver disease; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; fatty liver; gene expression; gene overexpression; human; human cell; in vitro study; in vivo study; liver cell; liver injury; male; mouse; nonhuman; oxidative stress; priority journal; promoter region; protein expression; receptor upregulation; regulatory mechanism; synthesis; transcription regulation; wild type; animal; biosynthesis; C57BL mouse; drug effect; gene expression regulation; genetics; Hep-G2 cell line; knockout mouse; liver; metabolism ⓘ English 2020 2020-02 10.1007/s00204-019-02648-7 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Antimicrobial Activity of Chrysoeriol 7 and Chochlioquinone 9, White-Backed Planthopper-Resistant Compounds, Against Rice Pathogenic Strains ⓘ Simple Summary This study is an important contribution to the development of biopesticide materials for controlling major pathogens in rice. Chrysoeriol 7 and cochlioquinone 9, which repel the white-backed planthopper, were extracted from rice and their antimicrobial activity was investigated. The results show they are effective in limiting the growth of pathogens of the genera Fusarium, Cladosporium and Pythium. This shows that they have great potential as an alternative to chemical pesticides and is also thought to be helpful in development of eco-friendly agriculture. As environmental damage caused by chemical pesticides appears worldwide, eco-friendly agriculture is increasing, and finding eco-friendly pesticide materials has become very important. Chrysoeriol and cochlioquinone, two flavonoids, act as an antibacterial and antioxidant, and increase the resistance of rice to the white-backed planthopper (WBPH). In this experiment, chrysoeriol 7 (C7) and cochlioquinone 9 (C9) were extracted from rice inoculated with the WBPH using MeOH, and cultivars with high extraction efficiency were selected. In addition, the antimicrobial activity of C7 and C9 against various pathogens causing disease in rice was tested. The results show that C7 has antifungal activity against Fusarium graminearum and Pythium graminicola, and C9 show antifungal activity against Cladosporium herbarum, Cladosporium cladosporioides, Gibberella zeae, Fusarium graminearum and Pythium graminicola. When both substances were treated at a concentration of 1000 ppm, they showed high inhibition rates of 62.3% and 36.2% against P. graminicola, respectively. After that, a phylogenetic tree was created to clarify the relationship between the microorganisms whose growth was inhibited and divided into three groups. This result can contribute to the study of biopesticide materials that can control pests and pathogens. ⓘ Jang, Yoon-Hee; Park, Jae-Ryoung; Kim, Kyung-Min ⓘ Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea ⓘ ; Kim, Kyung-Min Kim/C-7007-2014 ⓘ 57219901992; 57211205505; 34868260300 ⓘ uniunnie@naver.com;icd92@naver.com;kkm@knu.ac.kr; ⓘ BIOLOGY-BASEL ⓘ BIOLOGY-BASEL ⓘ 2079-7737 9 11 SCIE BIOLOGY ⓘ 2020 5.079 16.7 0.97 2025-06-25 ⓘ 13 15 rice; antimicrobial; white-backed planthopper; phylogenetic tree; biopesticide ⓘ SOGATELLA-FURCIFERA; EPI-COCHLIOQUINONES; FLAVONOIDS; AGENT; EXTRACTS; LUTEOLIN ⓘ Antimicrobial; Biopesticide; Phylogenetic tree; Rice; White-backed planthopper ⓘ ⓘ English 2020 2020-11 10.3390/biology9110382 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection ⓘ How evolution can be facilitated by epigenetic mechanisms has received refreshed attention recently. To explore the role epigenetic inheritance plays in evolution, we subject isogenic wild-type yeast cells expressing P-GALI-YFP (yellow fluorescent protein) to selection by daily sorting based on reporter expression. We observe expression-level reductions in multiple replicates sorted for the lowest expression that persist for several days, even after lifting the selection pressure. Reduced expression is due to factors in the galactose (GAL) network rather than global factors. Results using a constitutively active GAL network are in overall agreement with findings with the wild-type network. We find that the local chromatin environment of the reporter has a significant effect on the observed phenotype. Genome sequencing, chromatin immunoprecipitation (ChIP)-qPCR, and sporulation analysis provide further insights into the epigenetic and genetic contributors to the expression changes observed, Our work provides a comprehensive example of the role played by epigenetic mechanisms on gene network evolution. ⓘ Luo, Xinyue; Song, Ruijie; Moreno, David F.; Ryu, Hong-Yeoul; Hochstrasser, Mark; Acar, Murat ⓘ Yale Univ, Dept Mol Cellular & Dev Biol, 219 Prospect St, New Haven, CT 06511 USA; Yale Univ, Syst Biol Inst, 850 West Campus Dr, West Haven, CT 06516 USA; Yale Univ, Interdept Program Computat Biol & Bioinformat, 300 George St,Suite 501, New Haven, CT 06511 USA; Yale Univ, Dept Mol Biophys & Biochem, 266 Whitney Ave, New Haven, CT 06520 USA; Yale Univ, Dept Phys, 217 Prospect St, New Haven, CT 06511 USA; Kyungpook Natl Univ, Coll Natl Sci, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu 41566, South Korea ⓘ Acar, Murat/AIB-8244-2022; Hoet, Peter/H-9987-2013; Fortuño, David/T-7905-2018 ⓘ ⓘ murat.acar@yale.edu; ⓘ CELL REPORTS ⓘ CELL REP ⓘ 2211-1247 33 4 SCIE CELL BIOLOGY ⓘ 2020 9.423 16.7 ⓘ 10 ⓘ MEIOTIC RECOMBINATION; DOSAGE COMPENSATION; DNA METHYLATION; INHERITANCE; CHROMATIN; MUTATIONS; DYNAMICS; LAMARCK; MEMORY ⓘ ⓘ ⓘ English 2020 2020-10-27 10.1016/j.celrep.2020.108306 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Facile synthesis of a novel nitrogen-doped carbon dot adorned zinc oxide composite for photodegradation of methylene blue ⓘ Nitrogen-doped carbon dot decorated zinc oxide nanoparticles (N-CDs@ZnO composite) were successfully fabricated by an economical wet-impregnation method and used as a photocatalyst for the degradation of aqueous methylene blue (MB) dye under UV-light at room temperature. The chemical composition and morphological features of the prepared N-CDs@ZnO composite were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and field emission scanning electron microscopy (FESEM). The photodegradation capability of the N-CDs@ZnO composite was compared with that of bare ZnO nanoparticles, under identical experimental conditions. The results show that the N-CDs@ZnO composite exhibits notably higher photocatalytic activity (degradation efficiency over 99%, 60 min) compared to bare ZnO nanoparticles (75%, 60 min) towards the degradation of MB under UV-light irradiation. Besides, the degradation obeyed the pseudo-first-order kinetics model with a photocatalytic rate constant (k) of 0.0557 min(-1), which was similar to 2.3 times higher than that of bare ZnO nanoparticles (0.0240 min(-1)). The crucial roles of N-CDs in the enhancement of the photocatalytic activity of the N-CDs@ZnO composite arise because the N-CDs can efficiently absorb UV-light and trap electrons, thus hindering the recombination of the photo-generated electron-hole pairs and also suppressing the photocorrosion of the ZnO nanoparticles in the N-CDs@ZnO composite. The N-CDs@ZnO composite not only showed good photocatalytic activity but also had good stability since the photocatalytic activity did not significantly decrease after three cycling tests. The present study shows that the N-CDs@ZnO composite can be considered as an ideal photocatalyst in the field of dye degradation. Overall, the present approach obeys green chemistry principles with the simple construction of the N-CDs@ZnO composite and the composite holds promise for the development of efficient photocatalytic systems. ⓘ Atchudan, Raji; Edison, Thomas Nesakumar Jebakumar Immanuel; Mani, Shanmugam; Perumal, Suguna; Vinodh, Rajangam; Thirunavukkarasu, Somanathan; Lee, Yong Rok ⓘ Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea; Inst Aeronaut Engn, Dept Sci & Humanities, Hyderabad 500043, India; Pusan Natl Univ, Sch Elect & Comp Engn, Busan 46241, South Korea; Vels Inst Sci Technol & Adv Studies VISTAS, Sch Basic Sci, Dept Chem, Chennai 600117, India ⓘ Edison, Thomas/N-8909-2015; Jebakumar Immanuel Edison, Thomas Nesakumar/N-8909-2015; perumal, suguna/N-9075-2017; RAJI, ATCHUDAN/C-9904-2017; Lee, Yong Rok/K-6373-2015; Lee, Yong/K-6373-2015 ⓘ 26648054700; 6506181821; 14040328600; 56673798900; 35727964800; 14068969400; 57330662900 ⓘ atchudanr@yu.ac.kr;yrlee@yu.ac.kr; ⓘ DALTON TRANSACTIONS ⓘ DALTON T ⓘ 1477-9226 1477-9234 49 48 SCIE CHEMISTRY, INORGANIC & NUCLEAR ⓘ 2020 4.39 16.7 5.27 2025-06-25 ⓘ 91 96 ⓘ GRAPHENE QUANTUM DOTS; TURN-ON DETECTION; PHOTOCATALYTIC DEGRADATION; GREEN SYNTHESIS; VISIBLE-LIGHT; FLUORESCENT-PROBE; HIGHLY EFFICIENT; ZNO; NANOPARTICLES; DYE ⓘ ⓘ Complexation; Degradation; Doping (additives); Field emission microscopes; Fourier transform infrared spectroscopy; II-VI semiconductors; Image enhancement; Metal nanoparticles; Nitrogen; Oxide minerals; Photocatalytic activity; Rate constants; Scanning electron microscopy; X ray photoelectron spectroscopy; Zinc oxide; Attenuated total reflectance Fourier transform infrared; Experimental conditions; Field emission scanning electron microscopy; Photocatalytic rate constant; Photodegradation of methylene blue; Photogenerated electrons; Pseudo first-order kinetics; Zinc oxide nanoparticles; ZnO nanoparticles ⓘ English 2020 2020-12-28 10.1039/d0dt02756a ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Facile synthesis of Mn-doped NiCo2O4 nanoparticles with enhanced electrochemical performance for a battery-type supercapacitor electrode ⓘ We report the synthesis of manganese-doped nickel cobalt oxide (Mn-doped NiCo2O4) nanoparticles (NPs) by an efficient hydrothermal and subsequent calcination route. The material exhibits a homogeneous distribution of the Mn dopant and a battery-type behavior when tested as a supercapacitor electrode material. Mn-doped NiCo2O4 NPs show an excellent specific capacity of 417 C g(-1) at a scan rate of 10 mV s(-1) and 204.3 C g(-1) at a current density of 1 A g(-1) in a standard three-electrode configuration, ca. 152-466% higher than that of pristine NiCo2O4 or MnCo2O4. In addition, Mn-doped NiCo2O4 NPs showed an excellent capacitance retention of 99% after 1000 charge-discharge cycles at a current density of 2 A g(-1). The symmetric solid-state supercapacitor device assembled using this material delivered an energy density of 0.87 mu W h cm(-2) at a power density of 25 mu W h cm(-2) and 0.39 mu W h cm(-2) at a high power density of 500 mu W h cm(-2). The cost-effective synthesis and high electrochemical performance suggest that Mn-doped NiCo2O4 is a promising material for supercapacitors. ⓘ To Van Nguyen; Le The Son; Vu Van Thuy; Vu Dinh Thao; Hatsukano, Masahito; Higashimine, Koichi; Maenosono, Shinya; Chun, Sang-Eun; Tran Viet Thu ⓘ Le Quy Don Tech Univ, Dept Chem Engn, 236 Hoang Quoc Viet, Hanoi 100000, Vietnam; Japan Adv Inst Sci & Technol, Sch Mat Sci, 1-1 Asahidai, Nomi, Ishikawa 9231292, Japan; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Duy Tan Univ, Inst Res & Dev, Danang 550000, Vietnam ⓘ Thu, Tran Viet/H-5205-2011; Maenosono, Shinya/E-9494-2011 ⓘ 57871258000; 57216221157; 57216958279; 57203855623; 57214603341; 6505844357; 6701605610; 36801080300; 35489282800 ⓘ sangeun@knu.ac.kr;tranvietthu1@duytan.edu.vn; ⓘ DALTON TRANSACTIONS ⓘ DALTON T ⓘ 1477-9226 1477-9234 49 20 SCIE CHEMISTRY, INORGANIC & NUCLEAR ⓘ 2020 4.39 16.7 4.74 2025-06-25 ⓘ 89 88 ⓘ ALL-SOLID-STATE; HYDROTHERMAL SYNTHESIS; NICKEL COBALTITE; ENERGY-STORAGE; CARBON; GRAPHENE; OXIDES; ARCHITECTURES; ACTIVATION; HYDROXIDES ⓘ ⓘ Cobalt compounds; Cobalt deposits; Cost effectiveness; Electric discharges; Hydrothermal synthesis; Nanoparticles; Nickel oxide; Secondary batteries; Supercapacitor; Capacitance retention; Charge-discharge cycle; Electrochemical performance; Homogeneous distribution; Nickel cobalt oxides; Solid-state supercapacitors; Specific capacities; Supercapacitor electrodes; Electrochemical electrodes ⓘ English 2020 2020-05-28 10.1039/d0dt01177k ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Formation mechanism of an Al13 Keggin cluster in hydrated layered polysilicates ⓘ An Al-13 epsilon-Keggin cluster, AlO4Al12(OH)(24)(H2O)(12)(7+), is a predominant intermediate during the hydrolysis and polymerization of aluminum as well as a highly toxic substance to plants and fishes. However, no one could clearly explain why and how a cage-like Al-13 epsilon-Keggin cluster is formed even though it could be readily synthesized by the forced hydrolysis of Al3+. We found that the Al-13 epsilon-Keggin cluster was spontaneously formed not in monocrystalline octosilicate but in polycrystalline magadiite by the cation-exchange reaction with unhydrolyzed Al3+. Furthermore, the Al-13 epsilon-Keggin cluster was hardly detected in disaggregated magadiite crystals whose morphology was changed into monocrystalline crystals like octosilicate. Our findings prove that Al-13 formation is necessary to relieve localized inhomogeneity and rationalize that Al-13 is formed by the simultaneous co-assembly of four planar trimers and one octahedral monomer. In addition, the spontaneous formation of Al-13 in heterogeneous systems could be a vital clue to its evaluation in soils and sediments. ⓘ Park, Man; Kang, Yun-Ju; Jang, Jeong-Hun; Seo, Jae-Deok; Kim, Junhyung; Paek, Seung-Min; Lim, Woo-Taik; Komarneni, Sridhar ⓘ Kyungpook Natl Univ, Sch Appl Biosci, Soil Sci Lab, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Andong Natl Univ, Dept Appl Chem, Andong 760749, South Korea; Penn State Univ, Mat Res Lab, University Pk, PA 16802 USA ⓘ Paek, Seung-Min/E-4667-2011 ⓘ 36871192900; 57216430845; 57198251792; 57216441278; 56178833600; 7102686289; 7202378245; 35516544900 ⓘ manpark@knu.ac.kr; ⓘ DALTON TRANSACTIONS ⓘ DALTON T ⓘ 1477-9226 1477-9234 49 15 SCIE CHEMISTRY, INORGANIC & NUCLEAR ⓘ 2020 4.39 16.7 0.44 2025-06-25 ⓘ 6 6 ⓘ ALUMINUM-MAGADIITE; HYDROLYSIS; SPECIATION; SILICATES; KENYAITE; POLYCATION; CHEMISTRY; INSIGHTS; POLYMER ⓘ ⓘ Hydrolysis; Sediments; Cation exchange reactions; Forced hydrolysis; Formation mechanism; Heterogeneous systems; Inhomogeneities; Soils and sediments; Spontaneous formation; Toxic substances; Crystals ⓘ English 2020 2020-04-21 10.1039/d0dt00529k ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus ofPetunia hybridaCv. Mirage Rose ⓘ Despite the increasing use of protoplasts in plant biotechnology research, shoot regeneration from protoplasts remains challenging. In this study, we investigated the factors involved in protoplast isolation, callus induction, and shoot regeneration inPetunia hybridacv. Mirage Rose. The following conditions were found to be most optimal for protoplast yield and viability: 0.6 M mannitol, 2.0% cellulase, and 6 h digestion time. A plating density of 10 x 10(4)protoplasts/mL under osmoticum condition (0.58 M mannitol) showed high microcolony viability in liquid culture. The Kao and Michayluk medium was found to be appropriate for callus proliferation from microcalli under a 16-h light photoperiod. Calli cultured in Murashige and Skoog medium containing 1.0 mg/L 6-benzylaminopurine and 0.2 mg/L 3-indole butyric acid showed the highest shoot regeneration frequency and number of shoots obtained per explant. Random amplification of polymorphic DNA analysis showed that the protoplast-derived shoots exhibited the same banding patterns as those of donor plants. Collectively, these findings can contribute to solving problems encountered in protoplast isolation and shoot regeneration in other petunia cultivars and related species. As the protocol developed by us is highly reproducible, it can be applied in biotechnology research onP. hybridacv. Mirage Rose. ⓘ Kang, Hyun Hee; Naing, Aung Htay; Kim, Chang Kil ⓘ Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea ⓘ ; Naing, Aung Htay/AAF-4277-2019 ⓘ 57217681910; 37112768100; 7409880701 ⓘ a3220641@naver.com;aunghtaynaing2005@gmail.com;ckkim@knu.ac.kr; ⓘ BIOLOGY-BASEL ⓘ BIOLOGY-BASEL ⓘ 2079-7737 9 8 SCIE BIOLOGY ⓘ 2020 5.079 16.7 1.54 2025-06-25 ⓘ 29 31 digestion time; osmoticum conditions; plating density; plant growth regulators; protoplast viability ⓘ PLANT-REGENERATION; LEAF PROTOPLASTS; PETUNIA; CULTURE; GROWTH; CHRYSANTHEMUM; SYSTEM; DNA ⓘ Digestion time; Osmoticum conditions; Plant growth regulators; Plating density; Protoplast viability ⓘ ⓘ English 2020 2020-08 10.3390/biology9080228 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Sphingosine 1-phosphate receptor modulation attenuate mechanical allodynia in mouse model of chronic complex regional pain syndrome by suppressing pathogenic astrocyte activation ⓘ Background and objectives FTY720 ((2-amino-2-) 2-[4-octylphenyl]ethyl)-1,3-propanediol) is an Food and Drug Administration (FDA)-approved immunomodulatory drug for treating multiple sclerosis. It inhibits lymphocyte egression from lymphoid tissues by downregulating sphingosine-1 phosphate receptor (S1PR). To date, there has been no study on the effects of FTY720 on the chronic stage of the complex regional pain syndrome (CRPS) rodent model, despite its antiallodynic effect in previous studies. Thus, the aim of this study is to investigate the effect of FTY720 in a chronic stage of the CRPS mouse model. Method The authors used a mouse model of CRPS, involving tibia fracture/cast immobilization, to test the efficacy of intrathecal FTY720 (2.5 or 25 ng daily; 6 days) or vehicle during the chronic (7 weeks after fracture) stage of CRPS. Results Intrathecal recombinant FTY720 administration was antiallodynic in the chronic stage of the CRPS mouse model, and such an effect of FTY720 developed by modulating astrocyte activation in the spinal cord. Additionally, according to the in vitro data, the FTY720 treatment inhibited S1P-induced increase in the nitric oxide production and suppression of the NF-kappa B pathway, by inhibiting the phosphorylation of NF-kappa B/p65 in astrocytes without toxic effect on astrocytes. Conclusion Collectively, these results demonstrate that intrathecally administered FTY720 attenuates mechanical allodynia in the chronic stage of the CRPS mouse model. ⓘ Lee, Byung Joo; Kim, Jun Young; Cho, Hyung-jung; Park, Donghwi ⓘ Daegu Fatima Hosp, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea; Daegu Fatima Hosp, Lab Fatima Res Inst, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Ulsan, South Korea ⓘ Park, Donghwi/GYQ-6185-2022 ⓘ 57202436497; 35310922800; 57214099378; 56606561400 ⓘ bdome@hanmail.net; ⓘ REGIONAL ANESTHESIA AND PAIN MEDICINE ⓘ REGION ANESTH PAIN M ⓘ 1098-7339 1532-8651 45 3 SCIE ANESTHESIOLOGY ⓘ 2020 6.288 16.7 1 2025-06-25 ⓘ 13 13 ⓘ SPHINGOSINE-1-PHOSPHATE RECEPTORS; CENTRAL SENSITIZATION; MULTIPLE-SCLEROSIS; FTY720; INHIBITION; EXPRESSION; DISEASE; TARGETS ⓘ animal studies; chronic pain: complex regional pain syndrome; pain medicine ⓘ Animals; Astrocytes; Cytokines; Fingolimod Hydrochloride; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Spinal Cord; fingolimod; immunoglobulin enhancer binding protein; nitric oxide; sphingosine 1 phosphate receptor; synaptotagmin I; cytokine; fingolimod; glial fibrillary acidic protein; glial fibrillary astrocytic protein, mouse; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; astrocyte; cell activation; complex regional pain syndrome; controlled study; drug effect; immobilization; in vitro study; male; mechanical allodynia; mouse; mouse model; neuromodulation; nonhuman; priority journal; protein phosphorylation; spinal cord; tibia fracture; animal; astrocyte; C57BL mouse; hyperalgesia; metabolism; pharmacology ⓘ English 2020 2020-03 10.1136/rapm-2019-100801 ⓘ 바로가기 바로가기 바로가기 바로가기
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