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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Synthesis of a Natural Product-Based 5H-Thiazolo[5′,4′:5,6]pyrido[2,3-b]indole Derivative via Solid-Phase Synthesis The solid-phase synthesis method is optimized for building chemical libraries. Furthermore, chemical libraries are essential tools in drug discovery used to identify hit compounds. We constructed a 5H-thiazolo[5 ',4 ':5,6]pyrido[2,3-b]indole derivative library using solid-phase synthesis. The indole insertion reaction at the benzylic position using a Lewis acid and the oxidative cyclization reaction using iodine were used for synthesis. Using optimized solution-phase reaction conditions, a solid-phase synthesis method comprising a total of eight steps was employed to build a 5H-thiazolo[5 ',4 ':5,6]pyrido[2,3-b]indole derivative library. In addition, we found an efficient compound library synthesis route with each synthetic step having a yield of 62-82%. Moon, Jimin; Kim, Shinae; Hua, Shuanghui; Lee, Hyojin; Kim, Jungtae; Lee, Taeho Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80 Daehak Ro, Daegu, South Korea 59529084500; 57204720946; 59528942300; 59562877800; 59561861200; 57204032003 tlee@knu.ac.kr; JOURNAL OF ORGANIC CHEMISTRY J ORG CHEM 0022-3263 1520-6904 90 8 SCIE CHEMISTRY, ORGANIC 2024 3.6 16.7 0 2025-05-07 0 0 COMBINATORIAL CHEMISTRY; ANTIPLASMODIAL ACTIVITY; SIDE-CHAINS; NEOCRYPTOLEPINE; ACID; CRYPTOLEPINE; SUBSTITUTION; HETEROCYCLES; EFFICIENT; THIAZOLE Addition reactions; 5h thiazolo[5',4':5,6]pyrido[2,3 b]indole derivative; indole derivative; iodine; Lewis acid; natural product; unclassified drug; Benzylic; Chemical libraries; Drug discovery; Indole derivatives; Insertion reactions; Lewis Acid; Natural products; Oxidative cyclization; Solid phase synthesis; Synthesis method; Article; cyclization; drug structure; drug synthesis; oxidation; reaction optimization; solid phase synthesis; substitution reaction; Synthesis (chemical) English 2025 2025-02-20 10.1021/acs.joc.4c03094 바로가기 바로가기 바로가기 바로가기
Article Tuning MXene Pathways via Silver Nanoparticle Size Variations for Anode-Free Battery Applications MXenes, a class of two-dimensional titanium carbide materials, have emerged as promising materials for film-based applications due to their exceptional properties. However, their densely layered structures hinder ion diffusion, metal-ion mobility, and nanoscale particle transfer, limiting their potential in energy-related applications. Expanding and controlling interlayer spacing is essential for overcoming these limitations and optimizing MXene performance. In this study, silver nanoparticles (AgNPs) measuring 20 and 55 nm in size were incorporated into dense MXene structures to control and expand their pathways. X-ray diffraction confirmed the lamellar structure of pristine MXene, and detailed analyses using electron microscopy and small-angle neutron scattering demonstrated that the size and concentration of AgNPs directly influenced pathway expansion. The interlayer spacing increased significantly, with widths growing from 2.4 nm to similar to 25 nm as the AgNP parameters varied. Electrochemical impedance spectroscopy results revealed that the densely packed structure of pristine MXene was unsuitable for use as an anode-current collector coating in batteries. In contrast, the MXene/AgNP composite demonstrated effective functionality due to the expanded pathways, which improved ion transfer and conductivity. These findings underscore the importance of pathway engineering and the use of additive insertion methods in advancing MXene-based materials for energy storage and other functional applications. Lee, Sangho; Jang, Jong Dae; Jeong, Yu-Jun; Lee, Yonghee; Roh, Jong Wook; Hong, Seokjae; Kim, Hyungsub; Lim, Jisoo; Jin, Hyeong Min Korea Atom Energy Res Inst, Neutron Sci Div, Daejeon 34057, South Korea; Hanyang Univ, Dept Phys, Seoul 04763, South Korea; Hanyang Univ, Res Inst Convergence Basic Sci, Seoul 04763, South Korea; Kyungpook Natl Univ, Dept Nano & Adv Mat Sci & Engn, Sangju 37224, Gyeongsangbug D, South Korea; Chungbuk Natl Univ, Adv Energy Res Inst, Cheongju 28644, Chungbuk, South Korea; Chungnam Natl Univ, Dept Mat Sci & Engn, Daejeon 34134, South Korea; Chungnam Natl Univ, Dept Organ Mat Engn, Daejeon 34134, South Korea ; Jin, Hyeong/AAQ-5895-2021; Kim, Hyungsub/MTC-9305-2025; Lee, Jae/G-7717-2012 59418100800; 55972409300; 59551807200; 57348660100; 25638796100; 57225056239; 49561503500; 58631406500; 55079981800 hyeongmin@cnu.ac.kr; JOURNAL OF PHYSICAL CHEMISTRY LETTERS J PHYS CHEM LETT 1948-7185 16 7 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 2024 4.6 16.7 0 2025-05-07 0 0 PERFORMANCE Anode materials; Atomic emission spectroscopy; Lamellar structures; Metal nanoparticles; Nanoclay; Neutron scattering; Titanium carbide; metal ion; nanoparticle; silver nanoparticle; titanium carbide; Battery applications; Energy; Interlayer spacings; Ions diffusion; Layered Structures; Nanoparticle sizes; Property; Size variation; Titania; Two-dimensional; anode electrode; article; conductance; controlled study; diffusion; electron microscopy; impedance spectroscopy; ion transport; neutron scattering; pharmaceutics; X ray diffraction; Silver nanoparticles English 2025 2025-02-12 10.1021/acs.jpclett.4c03587 바로가기 바로가기 바로가기 바로가기
Article Harmonizing cross-cultural and transdiagnostic assessment of social cognition by expert panel consensus Social cognition, the perception and processing of social information, is adversely affected in multiple psychiatric, neurological, and neurodevelopmental disorders, and these impairments negatively impact quality of life for individuals across the globe. Despite the clear importance of social cognition, efforts to advance research via harmonization of data across cultures and diagnoses has been stymied by the lack of uniformly used and suitable assessments. To address this issue, the current study conducted an expert survey and consensus process to identify social cognitive assessments that are best suited for cross-cultural and transdiagnostic use among adults. A large group of experts in social cognition were surveyed to gather nominations for cross-culturally and transdiagnostically appropriate measures. These measures were then critically evaluated by a smaller group of experts using a Delphi consensus process to identify the best existing tasks for each use. Ninety-eight experts, representing 25 countries, responded to the initial survey and nominated a total of 81 tasks. Initial rounds of the Delphi process identified 50 tasks with adequate psychometric properties that were then subdivided into social cognition domains. For each domain, members ranked the five best tasks, once for cross-cultural use and once for transdiagnostic use, and rated the suitability of those tasks for the intended use. No tasks were identified as ideally suited for either use; however, within each domain, 4–5 tasks emerged as the most consistently selected, and all were ranked as having “good” or better suitability for use. While there is still a critical need for social cognitive assessments that are specifically designed for cross-cultural and transdiagnostic use, there does appear to be a handful of existing tasks that are currently available and likely informative. Caution is warranted however, as these still require comprehensive evaluation in cross-cultural and transdiagnostic studies. © The Author(s) 2025. Pinkham, Amy E.; Hajdúk, Michal; Ziermans, Tim; Van Rheenen, Tamsyn; Tavares, Tamara; Spink, Andrew; Sheffield, Julia; Rosema, Bram-Sieben; Penn, David L.; Oliver, Lindsay D.; Nagendra, Arundati; Mehta, Urvakhsh Meherwan; McDonald, Skye; Mazza, Monica; Livingston, Lucy; Lee, Taeyoung; Flores, Ana; Fett, Anne-Kathrin; Eddy, Clare M.; Davis, Beshaun; Chan, Raymond C. K.; Buunk, A.M.; Bonfils, Kelsey A.; Bodenhamer, Bodi; Bertoux, Maxime; Bang, Minji Department of Psychology, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United States; Department of Psychology, Faculty of Arts, Comenius University in Bratislava, Bratislava, Slovakia, The Centre for Psychiatric Disorders Research, Science Park, Comenius University in Bratislava, Bratislava, Slovakia, Department of Psychiatry, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovakia; Dutch Autism & ADHD Research Center, Department of Psychology, University of Amsterdam, Amsterdam, Netherlands, Department of Psychology, University of Amsterdam, Amsterdam, Netherlands; Department of Psychiatry, University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, Melbourne, VIC, Australia, Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Sydney, Melbourne, VIC, Australia; Department of Psychology, The Hospital for Sick Children, York University, Toronto, ON, Canada; Noldus Information Technology BV, Wageningen, Netherlands; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; HAMLETT study and “Kenniswerkplaats Onbegrepen Gedrag”, NHL Stenden Leeuwarden, and Expert by Experience for Anoiksis, Patiënt Association for Susceptibility for Psychosis, Leeuwarden, Netherlands; Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada; Schizophrenia & Psychosis Action Alliance, Alexandria, VA, United States; Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, India; School of Psychology, University of New South Wales, Sydney, NSW, Australia; Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Birmingham, United Kingdom, Neuroscience and Mental Health Innovation Institute, Cardiff University, Birmingham, United Kingdom; Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, South Korea; Silver School of Social Work, New York University, New York, NY, United States; Department of Psychology, City St George’s, University of London, School of Health & Medical Sciences, London, United Kingdom, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom; Research and Development, Birmingham and Solihull Mental Health NHS Foundation Trust, and College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, Department of Psychology, The University of Chinese Academy of Sciences, Beijing, China; Department of Neurology, Unit Neuropsychology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; School of Psychology, College of Education and Human Sciences, The University of Southern Mississippi, Hattiesburg, MS, United States; Department of Psychiatry, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Lille Neuroscience and Cognition, Inserm, University Lille, CHU Lille, Lille, France; Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea 6508264602; 57200573067; 15049087900; 55631496900; 9534395; 57197672389; 55323333000; 57795377100; 7005484939; 56206326100; 57194856089; 35754868000; 7202568889; 7006184739; 57190679761; 59510717700; 59648760800; 24390253800; 35483667500; 56230846600; 55708154200; 56829140000; 55939302700; 59647869200; 25926275300; 56583860800 amy.pinkham@utdallas.edu; Schizophrenia SCHIZOPHRENIA-UK N/A 2754-6993 11 1 SCIE PSYCHIATRY 2024 4.1 16.8 0 2025-05-07 1 adaptation; Article; attribution (psychology); attributional bias; cognition; consensus; Delphi study; emotion; evaluation study; human; mental disease; mental health; multiple choice test; neuroscience; professional knowledge; psychometry; questionnaire; schizophrenia; schizophrenia spectrum disorder; situational attribution; social cognition English Final 2025 10.1038/s41537-024-00540-7 바로가기 바로가기 바로가기
Article Severe Acute Kidney Injury with Necrotizing Glomerulonephritis After Piperacillin/Tazobactam Therapy in a Patient with Peritonitis: A Case Report and Literature Review Piperacillin/tazobactam (PT), a widely utilized broad-spectrum antibiotic, has been associated with acute kidney injury (AKI). Although the precise mechanism remains uncertain, and most cases of PT-associated AKI are mild, this report describes a rare and severe complication of PT, which manifested as severe AKI with necrotizing glomerulonephritis requiring hemodialysis. A 42-year-old man was transferred to the nephrology clinic due to progressive deterioration of kidney function. Prior to the transfer, the patient had been diagnosed with appendicitis complicated by peritonitis and received intravenous PT for 8 days. Baseline kidney function was normal, but serum creatinine subsequently increased to 7.2 mg/dL. Hemodialysis was initiated to address metabolic acidosis and edema. Kidney biopsy revealed severe acute tubular injury and necrotizing glomerulonephritis. Steroid therapy was initiated based on the biopsy findings, and serum creatinine returned to normal levels after 4 weeks of treatment. This case demonstrates that severe AKI with necrotizing glomerulonephritis can occur after PT use. Prompt kidney biopsy and the timely initiation of immunosuppressive therapy are essential for a favorable outcome. Oh, Youn-Sik; Han, Man-Hoon; Kim, Yong-Jin; Jeon, You Hyun; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Lim, Jeong-Hoon Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu 41944, South Korea Jung, Hee-Yeon/AFB-8578-2022; Cho, Jang-hee/ABD-3534-2020; Lim, Jeong-Hoon/ABE-6003-2020; Park, Sun-Hee/LMN-0033-2024 59679905200; 57194067936; 56150365500; 57820096000; 57196396467; 7501393222; 7403536291; 7501831741; 8558530700; 55633533600; 55360244300 aticucu@naver.com; mhhan1@knu.ac.kr; yyjjkim@knu.ac.kr; yh-jeon@knu.ac.kr; hy-jung@knu.ac.kr; jyss1002@hanmail.net; jh-cho@knu.ac.kr; sh-park@knu.ac.kr; drcdkim@knu.ac.kr; ylkim@knu.ac.kr; jh-lim@knu.ac.kr; DIAGNOSTICS DIAGNOSTICS 2075-4418 15 5 SCIE MEDICINE, GENERAL & INTERNAL 2024 3.3 17.0 0 2025-05-07 0 0 piperacillin/tazobactam-induced nephrotoxicity; acute kidney injury; drug-induced acute interstitial nephritis; necrotizing glomerulonephritis; antibiotic-related nephrotoxicity RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; ACUTE INTERSTITIAL NEPHRITIS; CRESCENTIC GLOMERULONEPHRITIS; NEPHROTOXICITY; TAZOBACTAM acute kidney injury; antibiotic-related nephrotoxicity; drug-induced acute interstitial nephritis; necrotizing glomerulonephritis; piperacillin/tazobactam-induced nephrotoxicity albumin; bicarbonate; C reactive protein; calcium; creatinine; cystatin C; methylprednisolone; neutrophil gelatinase associated lipocalin; phosphate; piperacillin plus tazobactam; potassium; sodium; uric acid; abdominal discomfort; abdominal tenderness; acute appendicitis; acute kidney failure; acutely ill patient; adult; albumin blood level; antibiotic therapy; appendix perforation; Article; ascites; bicarbonate blood level; blood gas analysis; blood pH; brush border; calcium blood level; carbon dioxide tension; case report; clinical article; computer assisted tomography; crackle; creatinine blood level; drug dose reduction; fever; fibrinoid necrosis; follow up; hematuria; hemodialysis; histopathology; hospital admission; human; human tissue; hydration; hypervolemia; kidney biopsy; kidney interstitium; laparoscopic appendectomy; leukocyte count; light microscopy; malaise; male; medical history; metabolic acidosis; necrotizing glomerulonephritis; nephrology; neutrophil chemotaxis; outpatient department; periodic acid Schiff stain; periorbital edema; peripheral edema; peritonitis; phosphate blood level; physical examination; pleura effusion; postoperative period; potassium blood level; protein blood level; protein creatinine ratio; proteinuria; respiratory alkalosis; right lower abdominal quadrant; sodium blood level; steroid therapy; treatment duration; urea nitrogen blood level; uric acid blood level; urinalysis; urine volume; venous blood English 2025 2025-03 10.3390/diagnostics15050574 바로가기 바로가기 바로가기 바로가기
Article # Language processing characteristics in normal pressure hydrocephalus: insights from eye-tracking analysis of incorrect responses Introduction In patients with Normal Pressure Hydrocephalus (NPH), the aging process results in decreased efficiency of cerebrospinal fluid circulation, leading to ventricular enlargement. This enlargement compresses several brain structures, impairing functions such as visual perception, semantic memory processing, and phonological encoding contributing to language processing difficulties. This study examines real-time language processing in NPH patients and healthy elderly (HE) controls by comparing their eye movements during correct and incorrect responses in a lexical retrieval task (LRT).Methods A total of 26 subjects participated, comprising 14 patients diagnosed with NPH (aged 65 or older) and 12 individuals in the HE group. A lexical retrieval task was administered as their eye movements were recorded. A Mann-Whitney U test was performed to compare LRT performance and eye-tracking metric results across different groups, respectively. Also, correlation analysis was performed to examine the relationship between LRT scores and eye-tracking scores. A two-way mixed ANOVA was conducted to assess the significance of eye-tracking metrics depending on response type (correct/incorrect). Additionally, a qualitative and quantitative comparison of heatmaps and scanpaths was conducted to visualize eye-tracking data for correct and incorrect items.Results The NPH group exhibited significantly lower performance in lexical retrieval compared to the HE group, accompanied by more counts and longer durations in both fixation and saccade metrics. A negative correlation was noted between LRT scores and eye-tracking metric values, with correlation coefficients predominantly at 0.50 or higher. Analysis of eye movements during correct and incorrect responses uncovered significant group and within-group effects across all metrics, with more intergroup differences during incorrect responses. Qualitative differences in eye movements were more noticeable in images associated with incorrect items.Discussion This study highlights previously under-explored language deficits in NPH patients using real-time visual processing analysis, underscoring the importance of targeted language interventions for these populations. Kim, Ji-Yeong; Lee, Jiho; Kim, Nayeon; Park, Ki-Su; Yoon, Janghyeok; Kang, Kyunghun; Ha, Ji-Wan Daegu Univ, Dept Speech Language Pathol, Gyongsan, South Korea; Neopons Inc, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Konkuk Univ, Dept Ind Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea 57208648151; 57221320001; 57072206000; 55932363100; 59696465200; 55365592200; 57072470300 jw-ha@daegu.ac.kr; FRONTIERS IN AGING NEUROSCIENCE FRONT AGING NEUROSCI 1663-4365 17 SCIE GERIATRICS & GERONTOLOGY;NEUROSCIENCES 2024 4.5 17.1 N/A 0 0 NPH; eye-tracking; language processing; object naming; incorrect response; lexical error eye-tracking; incorrect response; language processing; lexical error; NPH; object naming aged; Article; benchmarking; clinical article; controlled study; correlation analysis; eye movement; eye tracking; female; grid occupancy; human; incorrect response; language processing; male; mathematical analysis; nearest neighbor index; neurologic examination; normotensive hydrocephalus; outcome assessment; outcomes research; physical examination; qualitative analysis; quantitative analysis; saccadic eye movement; semantic memory; spatial dispersion English 2025 2025-04-23 10.3389/fnagi.2025.1527962 바로가기 바로가기 바로가기 바로가기
Article Functionalization, Properties and Applications of Hydrogenated Two-Dimensional Materials Hydrogenated two-dimensional (2D) materials have gained significant attention due to their tunable properties, which can be engineered through various functionalization techniques. This review discusses hydrogenated Xenes, a new class of fully hydrogenated mono-elemental 2D materials, including graphane, germanane, silicane, and stanane. Hydrogenation enhances the properties of Xenes, making them transparent, mechanically strong, electrically conductive, and rare. These materials offer a unique combination of characteristics that make them highly desirable for a variety of advanced applications in energy storage, organic electronics, and optoelectronics. Xenes such as silicane and germanane are semiconductors with tunable bandgaps, making them ideal for use in transistors, logic circuits, and sensors. Their electronic and optical properties can be finely adjusted, allowing them to be used in high-performance devices like LEDs, solar cells, and photodetectors. Furthermore, hydrogenated Xenes show potential in applications like batteries, supercapacitors, hydrogen storage, piezoelectricity, and biosensing, owing to their high surface area and versatility. This review also explores the impact of various hydrogenation techniques, including plasma treatment, wet chemical methods, and electrochemical hydrogenation, on the electronic, mechanical, thermal, optical, and magnetic properties of these materials. Advanced characterization techniques, such as X-ray absorption spectroscopy (XANES), have provided valuable insights into the electronic structure and bonding environments of these materials. Finally, the paper highlights the challenges and limitations of hydrogenation, including structural instability and environmental concerns, while discussing the future prospects and advancements needed to harness the full potential of hydrogenated 2D materials. This review serves as a comprehensive resource for researchers aiming to explore the applications of hydrogenated Xenes in next-generation technologies. © The Author(s) under exclusive licence to Tianjin University 2025. Ahmed, Shakeel; Altaf, Faizah; Manavalan, Rajesh Kumar; Dharman, Ranjith Kumar; Naseem, Kashif; Khan, Jahanzeb; Miao, Baoji; Kim, Sung Yeol; Zhang, Han; Ponraj, Joice Sophia School of Material Science and Engineering, Henan International Joint Laboratory of Nano-Photoelectric Magnetic Materials, Henan University of Technology, Zhengzhou, 450001, China; Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management (IR-HTCM), King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, 31261, Saudi Arabia; Institute of Natural Science and Mathematics, Ural Federal University, Yekaterinburg, 620002, Russian Federation; School of Mechanical Engineering, Kyungpook National University, Daegu, 702701, South Korea; School of Material and Environmental Engineering, Hunan University of Humanities Science and Technology, Loudi, 417000, China; Department of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur, 10250, Pakistan; School of Material Science and Engineering, Henan International Joint Laboratory of Nano-Photoelectric Magnetic Materials, Henan University of Technology, Zhengzhou, 450001, China; School of Mechanical Engineering, Kyungpook National University, Daegu, 702701, South Korea; College of Physics and Optoelectronics, Shenzhen University, Shenzhen, 518000, China; Centre for Advanced Materials, Aaivalayam-Dynamic Integrated Research Academy and Corporations (A-DIRAC), Coimbatore, 641046, India 57220888444; 56256311200; 59564608200; 57287207100; 58826221700; 57200374731; 55454383400; 19337822900; 57441156200; 55778648500 rajeshkumar_vgm@yahoo.com; joicesophia327@yahoo.co.in; Transactions of Tianjin University T TIANJIN U 1006-4982 1995-8196 ESCI ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 8.5 17.1 N/A 0 2D materials; Bandgap tuning; Energy storage; Germanane; Graphane; Hydrogenation xanes; Silicane; Stanene Hydrogenolysis; Image sensors; Integrated optoelectronics; Layered semiconductors; Light emitting diodes; Narrow band gap semiconductors; Photoelectric cells; Phototubes; Plasma deposition; Plasma diagnostics; Wide band gap semiconductors; X ray absorption spectroscopy; Band-gap tuning; Energy; Functionalizations; Germanane; Graphane; Hydrogenation xanes; Silicane; Stanene; Two-dimensional materials; XANES; Photodetectors English Article in press 2025 10.1007/s12209-025-00431-7 바로가기 바로가기 바로가기
Article Intraperitoneal paclitaxel with systemic S-1 plus oxaliplatin for advanced or recurrent gastric cancer with peritoneal metastasis: A single-arm, multicenter phase II clinical trial Background: Patients with peritoneal metastasis from gastric cancer show poor prognosis with standard systemic chemotherapy. This prospective multicenter phase II clinical trial was performed to evaluate the efficacy and safety of intraperitoneal paclitaxel combined with systemic S-1 plus oxaliplatin for patients with advanced or recurrent gastric cancer with peritoneal metastasis. Patient and method: Patients with advanced or recurrent gastric cancer with histologically or radiologically confirmed peritoneal metastases were eligible for the study. The chemotherapy regimen consisted of eight cycles of intraperitoneal paclitaxel 80 mg/m2 on days 1 and 8, combined with 80 mg/m2 S-1 for days 1-14, and 100 mg/m2 oxaliplatin on day 1, repeated every 21 days. The primary endpoint was 6-month progression-free survival. One-year progression-free and overall survival, response rate, and safety were set as the secondary endpoints. Result: In total, 28 patients were included in the study, of which 24 were analyzed, with the exception of those lost to follow-up and withdrawal of consent. The 6-months progression-free survival was 82.6 % (95 % CI: 68.5-99.6 %). The one-year progression-free and overall survival rates were 69.6 % (95 % CI: 53.1-91.2 %) and 76.9 % (95 % CI: 61-97 %), respectively. The overall response rate was 41.67 %. The hematologic toxicity profile showed grade 3/4 hematologic toxicities such as leukopenia (20.8 %), neutropenia (41.7 %), and thrombocytopenia (8.3 %). The only non-hematologic adverse event was grade 3 diarrhea. Three (12.5 %) patients experienced intraperitoneal chemoport-related adverse events. Conclusion: Bidirectional intraperitoneal paclitaxel with systemic S-1 plus oxaliplatin shows promising efficacy and safety in the treatment of peritoneal metastatic gastric cancer. Seo, Won Jun; Kim, Dong-Wook; Lee, Chang Min; Park, Ji Yeon; Jang, You-Jin; Park, Joong-Min; Kim, Jong Won; Jee, Ye Seob; Choi, Sung Il; Oh, Sang Chul; Kim, Jong-Han Korea Univ, Coll Med, Dept Surg, Div Foregut Surg, Seoul, South Korea; Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Surg, Cheonan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Chung Ang Univ Hosp, Dept Surg, Seoul, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Surg, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Med Oncol, Coll Med, Seoul, South Korea ; Kim, Dong/JCE-1975-2023; 박, 중민/GMW-4506-2022; Park, Ji Yeon/AAV-2471-2020; Seo, Won Jun/GOV-4789-2022; Lee, Chang/AAA-8912-2021 57202096954; 57203269284; 56901528900; 57196405216; 35573659700; 14030287200; 57192196582; 25923961900; 59727393100; 55647062500; 55081512500 ppongttai@gmail.com; EJSO EJSO-EUR J SURG ONC 0748-7983 1532-2157 51 6 SCIE ONCOLOGY;SURGERY 2024 2.9 17.1 0 2025-05-07 0 1 Stomach neoplasm; Peritoneal neoplasm; Injection; Intraperitoneal; Chemotherapy; Clinical trial; Phase II CHEMOTHERAPY Chemotherapy; Clinical trial; Injection; Intraperitoneal; Peritoneal neoplasm; Phase II; Stomach neoplasm Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Oxaliplatin; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Progression-Free Survival; Prospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; gimeracil plus oteracil potassium plus tegafur; oxaliplatin; paclitaxel; antineoplastic agent; oteracil; oxaliplatin; paclitaxel; S 1 (combination); tegafur; abdominal pain; adult; advanced cancer; anemia; anorexia; Article; cancer combination chemotherapy; cancer patient; cancer recurrence; clinical article; constipation; diarrhea; drug efficacy; drug safety; fatigue; female; follow up; hand foot syndrome; human; leukopenia; male; medical device complication; middle aged; multicenter study; multiple cycle treatment; nausea; neutropenia; overall response rate; overall survival; peritoneum metastasis; phase 2 clinical trial; progression free survival; prospective study; sensory neuropathy; stomach cancer; thrombocytopenia; vomiting; aged; clinical trial; drug combination; drug therapy; pathology; peritoneum tumor; stomach tumor; survival rate; tumor recurrence English 2025 2025-06 10.1016/j.ejso.2025.109603 바로가기 바로가기 바로가기 바로가기
Article Low-cost, high-efficiency double-sided neural probe Neural probes are indispensable in neuroscience research, enabling precise neuronal spike signal recording and electrical stimulation. Advancements in brain-computer interface technologies and the growing need to study neurological disorders have driven the increasing demand for accurate neural signal recording. While dual-sided probes address this demand, their scalability is limited by complex fabrication processes and high production costs. This study introduces a flexible, dual-sided neural probe that combines stable performance, cost efficiency (similar to$3.50 per unit) and rapid fabrication (similar to 7 days). Fabricated using commercially available flexible printed circuit board processes, the proposed probe simplifies packaging steps, making it well-suited for mass production. The probe, equipped with 16 dual-sided electrodes positioned on 4 shanks, successfully recorded neural signals across up to four brain regions, demonstrating high accuracy in both single- and multi-region recordings. The overall reduction in probe thickness was achieved by integrating photo solder resist (PSR) ink insulation, which helps minimize brain tissue damage. This cost-effective, scalable dual-sided probe holds significant potential for seamless integration with miniaturized wireless systems, and brain-computer interface (BCI) applications. Its enhanced accessibility and broader applicability in neuroscience research highlight its potential impact on the field. Lee, Haeyun; Park, Sehwan; Kim, Minseok; Lee, Jimin; Lee, Seungjun; Chou, Namsun; Shin, Hyogeun Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea; Korea Brain Res Inst KBRI, Emot Cognit & Behav Res Grp, Daegu, South Korea ; Chou, Namsun/AAS-3841-2020; 신, 효근/HSG-4622-2023 59663830000; 59664022100; 59073001500; 59663877100; 59664074300; 43061070600; 56591066700 nschou@kbri.re.kr; hyogeunshin@knu.ac.kr; SENSORS AND ACTUATORS A-PHYSICAL SENSOR ACTUAT A-PHYS 0924-4247 1873-3069 387 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION 2024 4.9 17.1 0 2025-05-07 1 1 Flexible neural probe; Double-sided neural probe; Low-cost; High-efficiency; Electrophysiology Double-sided neural probe; Electrophysiology; Flexible neural probe; High-efficiency; Low-cost Brain computer interface; Electronics packaging; Fabrication; Flexible electronics; Double sided; Double-sided neural probe; Electrical stimulations; Flexible neural probe; Higher efficiency; Interface technology; Low-costs; Neural probes; Signal recording; Spike signals; Neurons English 2025 2025-06-01 10.1016/j.sna.2025.116437 바로가기 바로가기 바로가기 바로가기
Article Metformin inhibits muscle atrophy through the PI3K/AKT/mTOR pathway in a rat model of acute rotator cuff tears Background: Muscle atrophy after the rupture of a rotator cuff (RC) tendon is a major factor that increases the risk of secondary complications and rerupture. Metformin, a type 2 diabetes treatment, can be used to modulate intracellular signaling pathways that promote muscle growth. This study aimed to verify whether systemic metformin administration could prevent supraspinatus (SS) atrophy after RC rupture in a rat model. Methods: This study is a comparative animal study aimed at investigating the effects of metformin. Twelve-week-old male Sprague-Dawley rats were used. The metformin group was administered intraperitoneal injection with 50 mg/kg metformin daily for 6 weeks after the RC tendon was cut, while the control group was given 0.9% saline solution. All rats were weighed and sacrificed 6 weeks after their surgery; then, SS were collected, and individual SS weights were measured. The expression of muscle atrophy genes was determined through quantitative reverse transcription polymerase chain reaction, and the amount of signal metabolism regulatory protein was measured by western blotting. Muscle atrophy and fatty infiltration (FI) were evaluated by histological staining. Results: Six weeks after RC tendon rupture, the SS weight in the metformin group was significantly higher than in the control group. Western blotting analysis revealed that the expression levels of phosphatidylinositol 3-kinase (P = .002), protein kinase B (P = .001), and mammalian targets of rapamycin (P = .009) protein were significantly higher in the metformin group than in the control group. The muscle atrophy-related marker genes Atrogin-1 (P = .036) and muscle-specific ring finger protein 1 (P < .000) in the metformin group were downregulated. The morphology of the SS, whose atrophy was prevented by metformin, had fewer wide pores and less reduced muscle fiber area than those of the control group. Muscle tissue staining analysis showed that FI was significantly suppressed by systemic metformin administration compared with that of the control group both qualitatively and quantitatively (P = .032). Metformin elicited an FI-suppressing effect by downregulating the adipogenic genes peroxisome proliferator-activated receptor gamma (P = .001) and CCAAT/enhancer-binding protein alpha (P < .001). Conclusions: Metformin significantly prevented SS atrophy by activating the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway in an acute RC tear rat model. It also suppressed FI by downregulating adipogenic factors in the late stage of RC tear. These results strongly supported the usefulness of metformin for high-quality muscle preservation after RC rupture in clinical practice. Level of evidence: Basic Science Study; In-Vivo Animal Model (c) 2024 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Yoon, Jong Pil; Park, Sung-Jin; Kim, Dong-Hyun; Choi, Yoon Seong; Lee, Hyun Joo; Chung, Seok Won Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Carbon Hybrid Fiber Sci, Daegu, South Korea; Konkuk Univ, Dept Orthopaed Surg, Med Ctr, Seoul, South Korea 36098548400; 58527890700; 57198637188; 57013770300; 58838750100; 37065938600 knuhos_sh2@naver.com; JOURNAL OF SHOULDER AND ELBOW SURGERY J SHOULDER ELB SURG 1058-2746 1532-6500 34 7 SCIE ORTHOPEDICS;SPORT SCIENCES;SURGERY 2024 2.9 17.1 0 2025-05-07 0 0 Metformin; rotator cuff tear; muscle atrophy; fatty infiltration; histological analysis; PI3K/AKT/mTOR pathway; supraspinatus Basic Science Study; fatty infiltration; histological analysis; In-Vivo Animal Model; Metformin; muscle atrophy; PI3K/AKT/mTOR pathway; rotator cuff tear; supraspinatus Animals; Blotting, Western; Disease Models, Animal; Hypoglycemic Agents; Male; Metformin; Muscular Atrophy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rotator Cuff Injuries; Signal Transduction; TOR Serine-Threonine Kinases; atrogin 1; CCAAT enhancer binding protein alpha; mammalian target of rapamycin; metformin; muscle RING finger 1 protein; peroxisome proliferator activated receptor gamma; phosphatidylinositol 3 kinase; protein kinase B; sodium chloride; antidiabetic agent; metformin; mTOR protein, rat; phosphatidylinositol 3 kinase; protein kinase B; target of rapamycin kinase; acute disease; Akt signaling; animal experiment; animal model; animal tissue; Article; controlled study; down regulation; drug effect; drug inhibition; gene expression; histology; histopathology; male; morphology; muscle atrophy; muscle cell; muscle tissue; muscle weight; nonhuman; prophylaxis; protein expression level; qualitative analysis; quantitative analysis; rat; rat model; real time reverse transcription polymerase chain reaction; rotator cuff rupture; supraspinatus muscle; treatment duration; Western blotting; animal; disease model; drug effect; etiology; metabolism; muscle atrophy; prevention and control; rotator cuff injury; signal transduction; Sprague Dawley rat English 2025 2025-07 10.1016/j.jse.2024.10.030 바로가기 바로가기 바로가기 바로가기
Article Survival benefit of adjuvant chemotherapy in high-risk patients with colon cancer regardless of microsatellite instability Introduction: The predictive utility of high-risk features (HRFs) and microsatellite instability (MSI) status for adjuvant chemotherapy (ACT) in patients with stage II colon cancer remains unclear. We examined the impact of HRFs and MSI in predicting the benefits of adjuvant ACT in patients with stage II colon cancer. Materials and methods: We included 1801 patients with resected stage II colon cancer who underwent ACT (5fluorouracil [FU] and oxaliplatin) or surgery alone between January 2010 and December 2017. The primary outcomes were overall survival (OS) and disease-free survival (DFS). Results: Among MSI-high patients with HRFs, patients who received 5- FU and oxaliplatin-based ACT had significantly higher OS and DFS than patients who did not, with no significant difference between those who received 5-FU and oxaliplatin as ACT. Among MSI-low/microsatellite stable patients with HRFs, patients who received 5-FU and oxaliplatin as ACT had significantly higher OS and DFS than patients who did not, with no significant differences between those who received 5-FU and oxaliplatin as ACT. Among patients who did not receive ACT, OS and DFS were 95.0 % and 91.2 % for patients without HRFs, respectively, and 84.4 % and 75.0% for patients with HRFs, respectively. ACT improved the survival rates of patients with HRFs (OS: 84.4 %-*95.9 %, DFS: 75.0 %-*88.9 %). Conclusions: ACT can be recommended for patients having stage II colon cancer with one or more HRF(s) for recurrence, regardless of the MSI status. In patients with HRFs, we observed no significant difference regarding survival between those who received 5-FU and oxaliplatin-based ACT. Bae, Sung Uk; Lee, Jong Lyul; Yang, Chun-Seok; Park, Eun Jung; Park, Soo Yeun; Kim, Chang Woo; Ji, Woong Bae; Son, Gyung Mo; Han, Yoon Dae; Kim, So Hyun; Kim, Min Sung; Park, Youn Young; Ha Lee, Kyung; Kim, Chang Hyun; Ha, Gi Won; Lee, Jaeim; Kim, Kyeong Eui; Jeong, Woon Kyung; Kim, Duck-Woo; Baek, Seong Kyu Keimyung Univ, Sch Med, Dept Surg, 1035 Dalgubeol Daero, Daegu 42601, South Korea; Dongsan Hosp, 1035 Dalgubeol Daero, Daegu 42601, South Korea; Asan Med Ctr, Dept Surg, Divs Colon & Rectal Surg, Seoul 05505, South Korea; Univ Ulsan, Coll Med, Seoul 05505, South Korea; Daegu Catholic Univ, Catholic Univ Daegu, Med Ctr, Sch Med, Daegu 42472, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Surg, Seoul 06273, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, 807 Hogukro, Daegu 40414, South Korea; Ajou Univ, Sch Med, Dept Surg, Suwon 16499, South Korea; Korea Univ, Ansan Hosp, Dept Plast Surg, Ansan 15355, South Korea; Pusan Natl Univ, Pusan Natl Univ Yangsan Hosp, Sch Med, Dept Orthoped Surg, Yangsan 50612, South Korea; Yonsei Univ, Severance Hosp, Dept Surg, Div Colorectal Surg,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yeungnam Univ, Coll Med, Dept Surg, Daegu, South Korea; Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Surg, Seoul 01830, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Coll Med, Dept Surg, Seoul 05278, South Korea; Chungnam Natl Univ, Coll Med, Dept Surg, Daejeon, South Korea; Chonnam Natl Univ, Hwasun Hosp & Med Sch, Dept Surg, Hwasun 58128, South Korea; Res Inst Clin Med Jeonbuk Natl Univ, Biomed Res Inst Jeonbuk Natl Univ Hosp, Jeonju 54907, Jeonbuk, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Radiol, Uijongbu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Surg, Coll Med, 82 Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea Kim, Chang/G-5001-2015; Lww, Jong/W-1791-2019; Son, Gyung/W-2979-2019; Han, Yoondae/W-1325-2019; Park, Eun/W-1340-2019; Kim, chang/F-6457-2013; Bae, Sung/W-1915-2019; Ha, Gi/W-2026-2019 55748167300; 55194819000; 57193362434; 59318649700; 40561578300; 57205308396; 55373138400; 35741980300; 58826156400; 39361754400; 57225209043; 59727405900; 55548203300; 57214805950; 56562681000; 34870078600; 57743294300; 23018367900; 35368632500; 25930840200 kdw@snubh.org; sgbeak@dsmc.or.kr; EJSO EJSO-EUR J SURG ONC 0748-7983 1532-2157 51 6 SCIE ONCOLOGY;SURGERY 2024 2.9 17.1 0 2025-05-07 0 0 Colonic neoplasms; Adjuvant chemotherapy; Microsatellite instability; Risk factors; Survival analysis; Precision medicine STAGE-II; MISMATCH REPAIR; FLUOROURACIL; THERAPY; OXALIPLATIN; LEUCOVORIN; MARKER Adjuvant chemotherapy; Colonic neoplasms; Microsatellite instability; Precision medicine; Risk factors; Survival analysis Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Microsatellite Instability; Middle Aged; Neoplasm Staging; Oxaliplatin; Retrospective Studies; Survival Rate; carcinoembryonic antigen; fluorouracil; oxaliplatin; antineoplastic agent; fluorouracil; oxaliplatin; adjuvant chemotherapy; adjuvant therapy; adult; aged; Article; body mass; cell differentiation; cohort analysis; colon cancer; colon tumor; controlled study; disease free survival; female; high risk patient; human; major clinical study; male; microsatellite instability; overall survival; perineural invasion; retrospective study; risk factor; sex ratio; survival analysis; survival rate; adjuvant chemotherapy; cancer staging; colectomy; drug therapy; genetics; middle aged; mortality; pathology; surgery; very elderly English 2025 2025-06 10.1016/j.ejso.2025.109674 바로가기 바로가기 바로가기 바로가기
Article Temperature dependence of the full material constants of [011]-poled Mn-doped 0.32PIN-0.39PMN-0.29PT single crystals, and its effect on the performance of an underwater Tonpilz transducer Transducers used actively in sonar systems are subject to prolonged transmission under high voltage, generating significant heat and experiencing temperature variations due to the operating environment. Piezoelectric single crystals exhibit changes in properties due to domain transformations, such as phase transitions, depending on the temperature. These changes affect the electrical and acoustic performance of transducers that use piezoelectric single crystals as active elements. In this study, the material constants of piezoelectric single crystals were derived under various temperature conditions, and the performance variations of transducers incorporating these constants were analyzed to investigate the impact of temperature changes on transducers. To this end, the electromechanical impedance of Mn: PIN-PMN-PT piezoelectric single crystal resonators polarized along the [011] crystal axis was measured at different temperatures. The complete set of physical constants was determined using the resonance method and optimization techniques based on the measured resonance frequency, anti-resonance frequency, and capacitance. The derived material constants were applied to a finite element model of a Tonpilz transducer to analyze the temperature-dependent characteristics of the transducer. Furthermore, a transducer structure insensitive to temperature variations was designed. This approach is expected to prevent the degradation of transducer efficiency and output due to temperature changes, thereby contributing to the performance stabilization of sonar systems. Kwon, Byungjin; Pyo, Seonghun; Eo, Junryong; Seo, Hee-Seon; Roh, Yongrae Agcy Def Dev, Chang Won 51678, South Korea; Kyungpook Natl Univ, 80 Daehakro, Daegu 41566, South Korea; iBULe Photon Inc, 7-39 Songdo Dong, Incheon 21999, South Korea 56513271000; 56715171600; 59745870800; 24765212200; 59815501000 yryong@knu.ac.kr; SENSORS AND ACTUATORS A-PHYSICAL SENSOR ACTUAT A-PHYS 0924-4247 1873-3069 390 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION 2024 4.9 17.1 0 2025-05-07 0 0 [011]-poled Mn: PIN-PMN-PT single crystal; Temperature-dependent material constants; Tonpilz transducer; Finite element analysis; TVR; Electromechanical impedance Electromechanical impedance; Finite element analysis; Temperature-dependent material constants; Tonpilz transducer; TVR; [011]-poled Mn: PIN-PMN-PT single crystal Acoustic impedance; Acoustic resonators; Acoustic transducers; Capacitance; Crystal resonators; Piezoelectric transducers; Piezoelectricity; Sonar; Underwater acoustics; Electromechanical impedance; Finite element analyse; Materials constants; Piezoelectric single crystals; PMN-PT single crystal; Temperature-dependent material; Temperature-dependent material constant; Tonpilz transducer; TVR; [011]-poled mn: PIN-PMN-PT single crystal; Single crystals English 2025 2025-08-16 10.1016/j.sna.2025.116602 바로가기 바로가기 바로가기 바로가기
Article A novel structure adaptive new information priority grey Bernoulli model and its application in China's renewable energy production At present, the global energy structure is undergoing major changes. China is in the transition period of energy structure. Accurately anticipating future energy trends is critical for China's energy structure and modernization. Considering the uncertainty and sparsity characteristics of China's energy system sequence, this study examines China's renewable energy scenario using the grey model with limited sample and uncertain system modelling features. Renewable energy is affected by a variety of uncertain factors, exhibiting a range of complicated traits including nonlinearity, periodicity and random volatility. The traditional grey model has been difficult to appropriately predict its future evolution. This paper focuses on the adaptability of the model, optimizes and improves the accumulation operator and model structure, and establishes a fractional-order structural self- adaptation grey Bernoulli model based on new information priority. Firstly, based on the new information priority accumulation operator, it is extended to the fractional order. In terms of model structure, combined with NGBM(1,1) model, SADGM(1,1) model and FPGM(1,1) model, periodic fluctuation term and nonlinear power term are included to improve the model's capacity to capture nonlinear, fluctuating and periodic features, and enhance the adaptability and flexibility of the model. The backward difference technique yields the model's parameter estimation and temporal response sequence. Based on the results of the algorithm comparison experiment, the Improved Grey Wolf Optimization Algorithm is chosen to optimize the structural parameters of the model in an effort to enhance its performance. The performance comparison experiment of the model was designed, and three cases of China's hydropower generation, China's renewable energy power generation installed capacity and China's solar energy quarterly power generation were selected to compare the performance with a variety of grey prediction models. Monte-Carlo simulation and probability density analysis were utilized to confirm the stability and accuracy of the proposed model. The results show that the proposed FSANGBM(1,1) model can handle data series of renewable energy with nonlinear, volatile, and periodic features with high prediction ability. Finally, the model is applied to forecast three cases' future development trends. Wang, Yong; Yang, Zhongsen; Zhou, Ying; Liu, Hao; Yang, Rui; Sun, Lang; Sapnken, Flavian Emmanuel; Narayanan, Govindasami Southwest Petr Univ, Sch Sci, Chengdu 610500, Sichuan, Peoples R China; Neijiang Normal Univ, Key Lab Numer Simulat Sichuan Prov Univ, Coll Math & Informat Sci, Neijiang 641000, Sichuan, Peoples R China; Univ Douala, Univ Inst Technol, Lab Technol & Appl Sci, POB 8698, Douala, Cameroon; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea 55733941200; 57807238600; 57020108900; 59451032000; 58591692200; 58492502000; 57193689653; 59146568100 ywangsc@qq.com; RENEWABLE ENERGY RENEW ENERG 0960-1481 1879-0682 239 SCIE ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY 2024 9.1 17.2 7.26 2025-05-07 2 5 Fractional order; Structural self-adaptation; Renewable energy prediction; Improved grey wolf optimization algorithm NATURAL-GAS CONSUMPTION; FORECASTING-MODEL; PREDICTION; ARIMA Fractional order; Improved grey wolf optimization algorithm; Renewable energy prediction; Structural self-adaptation China; Energy prediction; Energy structures; Fractional order; Gray wolves; Improved gray wolf optimization algorithm; Optimization algorithms; Renewable energies; Renewable energy prediction; Self- adaptations; Structural self-adaptation; algorithm; alternative energy; experimental study; hydroelectric power; optimization; parameter estimation; performance assessment; power generation; Prediction models English 2025 2025-02 10.1016/j.renene.2024.122052 바로가기 바로가기 바로가기 바로가기
Article Adverse events of tuberculosis preventive therapy among individuals with latent tuberculosis infection: A nationwide cohort study in South Korea Objectives: This study assessed adverse event with tuberculosis preventive therapy (TPT) regimens among individuals with latent tuberculosis infection (LTBI). Methods: Using national health insurance data, we analyzed individuals newly diagnosed with LTBI between 2015 and 2020. The TPT group, prescribed 3 months of isoniazid and rifampicin (3HR), 4 months of rifampicin (4R), or 9 months of isoniazid (9H), was matched with a control group through 1:1 propensity score matching. Drug-related adverse events were reported. Results: Of 220,483 diagnosed with LTBI, 49.0% received TPT, primarily 3HR (74.6%). The incidence of any adverse events with TPT was 11.90%, with 8.94% of these events being severe events requiring hospitalization. Hepatotoxicity risk was 6.48-, 4.79-, and 3.50-fold with 3HR, 9H, and 4R, respectively, compared to controls. Severe cutaneous adverse reaction risk was 4.27-, 1.83-, and 1.93-fold with 3HR, 9H, and 4R. 4R had the lowest risk of any adverse events, while 3HR had the highest. Permanent discontinuation occurred in 2.3%, 3.1%, and 3.3% with 4R, 9H, and 3HR, respectively. Unlike 9H, rifampicin-based regimens showed no age-related trend in adverse event risk. Conclusions: 4R is a better option considering safety across a broad age range, suggesting it could be encouraged in the LTBI population. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Oh, Sung-Hee; Lee, Jaehee; Jo, Junwoo; Kwon, Jin-Won Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea 57188550994; 13805476000; 57210425017; 16202951700 jwkwon@knu.ac.kr; INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES INT J INFECT DIS 1201-9712 1878-3511 156 SCIE INFECTIOUS DISEASES 2024 4.3 17.2 0 2025-06-11 0 0 Adverse events; Isoniazid; Latent tuberculosis infection; Rifampicin; Tuberculosis preventive therapy; Tuberculosis RIFAMPIN; CHALLENGES; SAFETY Adverse events; Isoniazid; Latent tuberculosis infection; Rifampicin; Tuberculosis; Tuberculosis preventive therapy isoniazid; rifampicin; adult; aged; Article; attributable risk; cohort analysis; comorbidity; controlled study; cumulative incidence; disease severity; female; follow up; health service; hospitalization; human; incidence; Kaplan Meier method; latent tuberculosis; liver toxicity; major clinical study; male; national health insurance; propensity score; retrospective study; severe cutaneous adverse reaction; South Korea; very elderly; visual impairment English 2025 2025-07 10.1016/j.ijid.2025.107914 바로가기 바로가기 바로가기 바로가기
Editorial Material An 81-year-old Woman with a 1-year-old Blue Pigmented Patch on the Right Upper Back: A Quiz Lee, Jin Young; Kim, Jun Young Kyungpook Natl Univ, Sch Med, Dept Dermatol, 130 Dongdeok ro, Daegu 41944, South Korea 59750783200; 35310922800 198kjy@hanmail.net; ACTA DERMATO-VENEREOLOGICA ACTA DERM-VENEREOL 0001-5555 1651-2057 105 SCIE DERMATOLOGY 2024 3.7 17.2 0 2025-05-07 0 0 DERMATOFIBROSARCOMA PROTUBERANS; DERMOSCOPY aged; blue nevus; case report; clinical article; dermatoscopy; female; histopathology; human; human tissue; immunohistochemistry; Note; pigmented dermatofibrosarcoma protuberans; punch biopsy; skin biopsy; skin pigmentation; very elderly; article; diagnosis English 2025 2025 10.2340/actadv.v105.42915 바로가기 바로가기 바로가기 바로가기
Article Design of a personalized oral-motor exercise device for speech impairment rehabilitation Introduction: Dysarthria is a speech disorder that stems from impaired muscle control due to lesions in the articulatory system, necessitating targeted rehabilitation exercises to strengthen affected muscles. Current devices used for rehabilitation often fail to accurately assess exercise execution, which limits their effectiveness.Methods: This study introduces a novel oral-motor rehabilitation device designed to overcome these limitations. The device features flexible sensors and a signal processing module that provides real-time feedback on training intensity. It is integrated with a mobile application that enables users to monitor their tongue's range of motion and track their progress through a calibration process that uses a simple moving average filter. A preliminary study was conducted with five healthy adult male subjects to verify the device's basic operational characteristics.Results: The effectiveness of the device in improving muscle function and regulating training intensity was evaluated using the Iowa Oral Performance Instrument. The results showed promising outcomes in enhancing articulation and oral-motor skills, indicating that the device could effectively contribute to dysarthria rehabilitation.Discussion: By addressing the gaps in current rehabilitation practices for dysarthria, the proposed device offers a comprehensive and personalized approach to oral-motor therapy. Its ability to provide immediate feedback and track progress can significantly enhance the rehabilitation process, potentially leading to better outcomes for patients with dysarthria. Woo, Seong Tak; Ha, Ji-Wan; Na, Sungdae Dong Seoul Univ, Dept Elect Engn, Seongnam, South Korea; Daegu Univ, Dept Speech & Language Pathol, Gyongsan, South Korea; Kyungpook Natl Univ Hosp, Dept Biomed Engn, Daegu, South Korea 59730405000; 57072470300; 56366244500 bluepoison14@knu.ac.kr; FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY FRONT BIOENG BIOTECH 2296-4185 13 SCIE ENGINEERING, BIOMEDICAL;BIOTECHNOLOGY & APPLIED MICROBIOLOGY 2024 4.8 17.2 0 2025-05-07 0 0 dysarthria rehabilitation; oral-motor exercise; self-calibration; speech therapy; tongue movement TONGUE STRENGTH; PERFORMANCE INSTRUMENT; STROKE PATIENTS; PRESSURE; ADULTS; ULTRASONOGRAPHY; INTERVENTION; DISORDERS; MOVEMENTS; PATTERNS dysarthria rehabilitation; oral-motor exercise; self-calibration; speech therapy; tongue movement Arthroplasty; Human rehabilitation equipment; Patient rehabilitation; 'current; Dysarthria; Dysarthria rehabilitation; Muscle controls; Oral-motor exercise; Rehabilitation exercise; Self calibration; Speech disorders; Speech therapy; Tongue movement; Exercise equipment English 2025 2025-03-27 10.3389/fbioe.2025.1543259 바로가기 바로가기 바로가기 바로가기
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