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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Effects of Elevated CO2 on Maize Physiological and Biochemical Processes | Maize (Zea mays) is a critical global crop, serving as a source of food, livestock feed, and industrial raw materials. Climate changes, driven by rising atmospheric carbon dioxide (CO2) levels, have substantial effects on maize physiology, growth, and nutrient content. This review investigates the impact of elevated CO2 on maize, with a particular focus on photosynthesis enhancement as it improves water use efficiency (WUE), which can lead to increased biomass production. Despite this, elevated CO2 results in a decreased concentration of essential nutrients, including nitrogen, phosphorus, potassium, and folate. The reduction in folate, which is vital for both plant development and human nutrition, poses challenges, especially for population heavily reliant on maize. Additionally, biofortification through traditional breeding and genetic engineering is proposed as a strategy to enhance folate level in maize to mitigate nutritional deficiencies. Elevated CO2 stimulates lignin production, improving stress resistance and carbon sequestration capacity. However, the increase in guaiacyl-rich lignin may negatively affect biomass degradability and efficiency in biofuel production. The findings emphasize the importance of balancing maize's stress resilience, nutrient profile, and lignin composition to address future climate challenges. This balance is essential for optimizing maize cultivation for food security, biofuel production, and environmental sustainability. | Khan, Pirzada; Aziz, Tariq; Jan, Rahmatullah; Kim, Kyung-Min | Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China; Jiangsu Univ, Fac Civil Engn & Mech, Zhenjiang 212013, Peoples R China; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/AIC-3439-2022 | 57747802700; 57189873999; 57201981969; 34868260300 | pirzada_111@yahoo.com; tariq@ujs.edu.cn; rahmat2021@knu.ac.kr; kkm@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 15 | 1 | SCIE | AGRONOMY;PLANT SCIENCES | 2024 | 3.4 | 15.9 | 0 | 2025-05-07 | 0 | 0 | climate changes; elevated CO2; folate biofortification; growth; lignin biosynthesis; nutrients; stress resistance | CARBON-DIOXIDE; FOLATE BIOFORTIFICATION; ATMOSPHERIC CO2; CLIMATE-CHANGE; NUTRIENT AVAILABILITY; LEAF PHOTOSYNTHESIS; METAANALYTIC TEST; ENRICHMENT FACE; INCREASING CO2; LIGNIN CONTENT | climate changes; elevated CO<sub>2</sub>; folate biofortification; growth; lignin biosynthesis; nutrients; stress resistance | English | 2025 | 2025-01 | 10.3390/agronomy15010202 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan | Cells experience a progressive decline in function and lifespan, accompanied by epigenetic changes. Here, we show that intracellular BCAA (icBCAA) homeostasis is regulated by histone H3K4 and H3K121 in budding yeast. Using a comprehensive H3/H4 mutant library, we identified residues essential for lifespan maintenance linked to BCAA metabolism. Among these, H3K4A/R and H3K121A mutations led to significant transcriptional changes in genes involved in BCAA biosynthesis and catabolism, accompanied by abnormally elevated icBCAA levels. Consistent with the upregulation of BAT1, ILV6, and ADH1 genes in the H3K121A mutant, chromatin immunoprecipitation revealed increased H3K4me3 at their promoters. The genetic perturbation of BAT1 and BAT2 restored icBCAA balance and partially rescued lifespan defects in H3K4 or H3K121 mutants. Additionally, H3K4 and H3K121 mutations affected lifespan regulation through TORC1 signaling. Our findings suggest that the epigenetic control of BCAA metabolism, specifically through the modification of histone residues, contributes to maintaining metabolic homeostasis and replicative lifespan. © 2025 The Author(s) | Park, Sejung; Liu, Yan; Lim, Suji; Ryu, Hong-Yeoul; Ahn, Seong Hoon | Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea; Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea; Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea; BK21 Plus KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University, Daegu, 41566, South Korea; Department of Medicinal and Life Science, College of Science and Convergence Technology, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea | 59957230300; 57263978200; 57222811485; 55889917800; 59958721500 | hoon320@hanyang.ac.kr; | iScience | ISCIENCE | N/A | 2589-0042 | 28 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 4.1 | 15.9 | 0 | Epigenetics; Microbial metabolism; Molecular genetics; Properties of biomolecules | English | Final | 2025 | 10.1016/j.isci.2025.112846 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Methodology for generating wildfire hazard map for safety assessment of off-site power systems against wildfires | Nuclear power plants (NPPs) transfer electricity using off-site power systems. Wildfires can disrupt these systems and cause a loss of off-site power, which can impact the operation of NPPs. In South Korea, wildfire incidents in 2000 and 2022 interrupted the operation of off-site power systems, affecting the NPPs. Furthermore, rising temperatures due to climate change are increasing the frequency of wildfires. Therefore, NPPs are expected to become more vulnerable to wildfires. Wildfire hazard maps are necessary for analyzing the impact of wildfires on NPPs. This paper proposes a methodology for generating a wildfire hazard map via Monte Carlo simulation. The proposed methodology was applied to the vicinity of the Hanul NPP, and a wildfire hazard map was generated. | Kim, Kyungmin; Park, Jinhee; Eem, Seunghyun; Kwag, Shinyoung | Kyungpook Natl Univ, Sch Convergence & Fus Syst Engn, Major Plant Syst Engn, Sangju 37224, South Korea; Korea Atom Energy Res Inst, Risk Assessment Res Div, Daejeon 34057, South Korea; Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Major Plant Syst Engn, Sangju 37224, South Korea; Hanbat Natl Univ, Dept Civil & Environm Engn, Daejeon 34158, South Korea | 59438308900; 54402165900; 52363442900; 55779491500 | kmk999@knu.ac.kr; jhpark6@kaeri.re.kr; eemsh@knu.ac.kr; skwag@hanbat.ac.kr; | NUCLEAR ENGINEERING AND TECHNOLOGY | NUCL ENG TECHNOL | 1738-5733 | 57 | 5 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 2.6 | 15.9 | 3.8 | 2025-05-07 | 1 | 1 | Wildfire hazard map; Nuclear power plant (NPP); Safety assessment; Off-site power system; Monte Carlo simulation (MCS); FlamMap | RISK | FlamMap; Monte Carlo simulation (MCS); Nuclear power plant (NPP); Off-site power system; Safety assessment; Wildfire hazard map | English | 2025 | 2025-05 | 10.1016/j.net.2024.11.029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Molecular Characterization of an EMS-Induced Ab-γg-Rich Saponin Mutant in Soybean (Glycine max (L.) Merr.) | Soybean is particularly known for accumulating saponins in its seeds. This study aimed to identify a causal gene to control an increase in Ab-gamma g saponin in PE1607 from an EMS-treated population of the soybean cultivar Pungsannamul. Segregation analysis in F2 seeds verified that a single recessive allele controlled the increased Ab-gamma g saponin in PE1607. Bulk segregant analysis and mutant individuals identified the candidate region, containing the previously reported Sg-3 (Glyma.10G104700) gene, encoding a glucosyltransferase responsible for conjugating glucose as the third sugar at the C-3 position of the aglycone. NGS identified SNPs in the upstream of the Sg-3 gene, designated as the sg-3b allele. Expression analysis revealed that PE1607 exhibited a threefold decrease in Sg-3 expression in the hypocotyls compared to the Pungsannamul. Moreover, Sg-3 expressions significantly differed between the hypocotyls and cotyledons in developing seeds, with relatively low expression observed in the cotyledons. The results conclude that sg-3b allele may contribute to the reduced Sg-3 expression, resulting in an increase in Ab-gamma g saponin in PE1607. In addition, in the cotyledons, DDMP-beta g and DDMP-beta a saponins are present, containing rhamnose instead of glucose as the third sugar at the C-3 position of aglycone. This suggests that Sg-3, known as glucosyltransferase, does not significantly contribute to saponin biosynthesis in cotyledons. | Park, Junbeom; Son, Haereon; Jo, Hyun; Tsukamoto, Chigen; Lee, Jinwon; Lee, Jeong-Dong; Seo, Hak Soo; Song, Jong Tae | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Iwate Univ, Fac Agr, 3-18-8 Ueda, Morioka 0208550, Japan; Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu 41566, South Korea; Seoul Natl Univ, Dept Agr Forestry & Bioresources, Seoul 08826, South Korea | 57816147100; 57208709910; 57194539358; 6603711026; 57210899223; 40462075100; 26642769200; 57797134000 | junfan5927@gmail.com; haereon12@gmail.com; johyun@knu.ac.kr; chigen@iwate-u.ac.jp; leejinwon@outlook.com; jdlee@knu.ac.kr; seohs@snu.ac.kr; jtsong68@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 15 | 3 | SCIE | AGRONOMY;PLANT SCIENCES | 2024 | 3.4 | 15.9 | 0 | 2025-05-07 | 0 | 0 | soybean; saponin; Ab-gamma g saponin; Sg-3; glucosyltransferase | TRITERPENOID SAPONINS; TRANSCRIPTION FACTOR; GENES; SEED; EXPRESSION; MACROAUTOPHAGY; SOYASAPOGENOL; INDUCTION; DIVERSITY; ELEMENT | Ab-γg saponin; glucosyltransferase; saponin; Sg-3; soybean | allele; cultivar; gene expression; induced response; molecular analysis; mutation; soybean | English | 2025 | 2025-03-05 | 10.3390/agronomy15030648 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Optimization of a water-intake system for monitoring radionuclides in aquatic environments | We designed and characterized a water-intake radiation monitoring system using a 3" x 3 '' NaI(Tl) detector for real-time monitoring of, for example, nuclear power plant radioactive effluents. The MCNP6 code was used to determine the optimized container size and detector position for homogeneous 131I and 137Cs volumetric sources. Based on the simulation results, the dimensions of the monitoring system were determined. The simulation model was initially verified by comparison with the measurement results of a paper filter certified reference materials in water. Subsequently, it was further validated by comparison with the detection efficiency for 40K in a KCl volumetric source measurement experiment, which confirmed that the detection efficiency well matched experimental data for volumetric sources. Using the validated simulation model, the detection efficiency of 131I and 137Cs volumetric sources in a water-filled container was assessed. To consider background radioactivity, three types of water samples-freshwater, brackish water, and seawater-were experimentally measured. Based on these measurements, the minimum detectable activity for 131I and 137Cs volumetric sources was determined for each of the three water sample types. | Lee, Dayeong; Maeng, Seongjin; Lee, Sang Hoon | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Hydro & Nucl Power Co, Radiat & Environm Dept, Disposal Technol Team, 1655 Bulguk Ro, Gyeongju Si 38120, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Radiat Sci Res Inst, Daegu 41566, South Korea | Maeng, Seongjin/JXW-7080-2024 | 59745307200; 56783843400; 59817149900 | lee@knu.ac.kr; | NUCLEAR ENGINEERING AND TECHNOLOGY | NUCL ENG TECHNOL | 1738-5733 | 57 | 9 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 2.6 | 15.9 | 0 | 2025-05-07 | 0 | 0 | Subaquatic radioactivity monitoring system; NaI(Tl) detector; Monte Carlo simulation; Minimum detectable activity | GAMMA-RAY SPECTROMETRY; RADIOACTIVITY MEASUREMENTS; IN-SITU; IMPACTS | Minimum detectable activity; Monte Carlo simulation; NaI(Tl) detector; Subaquatic radioactivity monitoring system | English | 2025 | 2025-09 | 10.1016/j.net.2025.103656 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Indirubin-3′-oxime as a dual-action agent: mitigating heat-induced male infertility in Drosophila melanogaster and inhibiting soluble epoxide hydrolase | This study investigated the potential of the indirubin-3 '-oxime (I3O) compound to mitigate temperature-induced male infertility in Drosophila melanogaster. Elevated temperatures significantly reduced egg-hatching rates, but I3O supplementation improved these rates, suggesting it can partially restore fertility under heat stress. Additionally, I3O was found to inhibit soluble epoxide hydrolase (sEH), an enzyme involved in the metabolism of epoxyeicosatrienoic acids, which are vital for reproductive health. I3O exhibited sEH inhibitions with an IC50 value of 59.74 +/- 0.41 mu M. Enzyme kinetics revealed that I3O acts as a non-competitive inhibitor of sEH with a Ki value of 78.88 mu M. Molecular docking showed strong interactions between I3O and key residues in the allosteric regions within the sEH enzyme, with a binding affinity of -9.2 kcal/mol. These interactions were supported by 100 ns molecular dynamics simulations, which confirmed the stability of the sEH-I3O complex. | Phong, Nguyen Viet; Kim, Hyo-Sung; Zhao, Yan; Yeom, Eunbyul; Yang, Seo Young | Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, Sch Life Sci & Biotech,KNU G LAMP Project Grp, Daegu, South Korea; Yantai Univ, Sch Pharm, Yantai, Peoples R China | Nguyen, Viet Phong/AAQ-4207-2021 | 57205196739; 57226241873; 57195927125; 56058004100; 57215036954 | yeb@knu.ac.kr; syy@knu.ac.kr; | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | J ENZYM INHIB MED CH | 1475-6366 | 1475-6374 | 40 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL | 2024 | 5.4 | 16.0 | 0 | 2025-05-07 | 0 | 0 | Indirubin-3 '-oxime; male infertility; Drosophila melanogaster; soluble epoxide hydrolase; molecular dynamics | IN-VIVO; DOCKING; FERTILITY | Drosophila melanogaster; Indirubin-3′-oxime; male infertility; molecular dynamics; soluble epoxide hydrolase | Animals; Dose-Response Relationship, Drug; Drosophila melanogaster; Enzyme Inhibitors; Epoxide Hydrolases; Hot Temperature; Indoles; Infertility, Male; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oximes; Structure-Activity Relationship; epoxide hydrolase; epoxyicosatrienoic acid; indirubin; indirubin 3' oxime; unclassified drug; enzyme inhibitor; epoxide hydrolase; indirubin-3'-monoxime; indole derivative; oxime; allosteric site; animal experiment; animal model; Article; binding affinity; controlled study; Drosophila melanogaster; enzyme inhibition; enzyme kinetics; female; hatchability; heat stress; hydrogen bond; IC50; male; male infertility; molecular docking; molecular dynamics; nonhuman; post hoc analysis; reproductive health; root mean squared error; scanning electron microscopy; surface analysis; surface area; animal; chemical structure; chemistry; dose response; drug therapy; high temperature; metabolism; structure activity relation; synthesis | English | 2025 | 2025-12-31 | 10.1080/14756366.2024.2447719 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Application of a Synthetic Microbial Community to Enhance Pepper Resistance Against Phytophthora capsici | Pepper (Capsicum annuum) production faces significant challenges from soil-borne pathogens, particularly Phytophthora capsici, which induces root rot and damping-off diseases. Management of this pathogen remains challenging owing to the scarcity of resistant cultivars and the ineffectiveness of chemical control methods. A single strain has been used to prevent pathogenic disease, and this approach limits the exploration of consortia comprising different genera. In this study, we isolated five bacterial strains (Bacillus sp. T3, Flavobacterium anhuiense T4, Cytobacillus firmus T8, Streptomyces roseicoloratus T14, and Pseudomonas frederiksbergensis A6) from the rhizosphere of healthy pepper plants. We then applied this 5-isolate synthetic microbial community (SynCom) to Capsicum annuum to evaluate its efficacy in improving pepper resilience against P. capsici. The SynCom members exhibited phosphate solubilization, indole-3-acetic acid production, catalase activity, siderophore synthesis, and strong antagonism against P. capsici. The SynCom reduced disease severity and enhanced the growth of pepper plants. Furthermore, the beneficial genera such as Bacillus, Fusicolla, and Trichoderma, significantly increased in the rhizosphere of pepper after the application of the SynCom. Microbial functional prediction analysis revealed that these microbial shifts were associated with nitrogen cycling and pathogen suppression. Our SynCom approach demonstrates the effectiveness of microbial consortia in promoting the growth of pathogen-infected plants by reprogramming the microbial community in the rhizosphere. | Bashizi, Tino Flory; Kim, Min-Ji; Lim, Kyeongmo; Lee, GyuDae; Tagele, Setu Bazie; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu 41566, South Korea; Univ Calif Riverside, Dept Microbiol & Plant Pathol, Riverside, CA 92507 USA | Tagele, Setu Bazie/IYJ-1959-2023; Kim, Min-Ji/Z-5205-2019 | 58537504300; 57127351600; 57805008000; 57222101785; 57202007103; 57224125922 | tino.bashizi@knu.ac.kr; tbd01188@knu.ac.kr; lkm3519@knu.ac.kr; leegyuedae@knu.ac.kr; setu.tagele@ucr.edu; jhshin@knu.ac.kr; | PLANTS-BASEL | PLANTS-BASEL | 2223-7747 | 14 | 11 | SCIE | PLANT SCIENCES | 2024 | 4.1 | 16.3 | N/A | 0 | 0 | Capsicum annuum; plant growth-promoting rhizobacteria; rhizosphere microbiome; sustainable agriculture; SynCom | Capsicum annuum; plant growth-promoting rhizobacteria; rhizosphere microbiome; sustainable agriculture; SynCom | English | 2025 | 2025-05-26 | 10.3390/plants14111625 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Characterization of fusidic acid-resistant Staphylococcus aureus isolated from food animals during 2010-2021 in South Korea | Livestock-associated fusidic acid-resistant Staphylococcus aureus (FRSA) is frequently linked to global public health hazards. This study aimed to ascertain the prevalence and molecular characteristics of FRSA isolated from food animal products in South Korea from 2010 to 2021. We obtained a total of 3980 S. aureus isolates from cattle carcasses (n = 482), pig carcasses (n = 1531), and chicken carcasses (n = 1967). The isolates were evaluated for antimicrobial susceptibility using the broth microdilution method. Antimicrobial resistance genes, spa types, sequence types (STs), and Staphylococcus cassette chromosome mec (SCCmec) types were determined by polymerase chain reaction (PCR) and sequencing analysis. In total, 187 isolates (4.7 %) demonstrated resistance to fusidic acid, with the maximum recovered from cattle (16.2 %), followed by pigs (6.5 %) and chickens (0.5 %). In addition, the majority of the isolates showed resistance to penicillin (86.6 %), while comparatively low resistance rates (7-13.9 %) were observed for erythromycin, gentamicin, kanamycin, and tetracycline. Moreover, multidrug resistance (MDR) comprised 8.6 % (16/187) of the isolates. Among the fusidic acid resistance determinants, the fusA mutation was the highest, containing 54 % (101/187), followed by fusC (29.4 %, 55/187) and fusB (15.5 %, 29/187). A high level of resistance regarding the substitution of L461K in the fusA gene was identified in 97 % of isolates. In addition, the most commonly detected resistance patterns include penicillin (87.1 %, 88/101) among the FRSA. The nucleotide sequencing analysis showed that all 29 fusB-car- rying isolates possess the structural gene blaZ of the bla operon and the insertion sequences orf152, orf170, IS257, and orf152. In total, 21 spa types were found, where t126 was detected the most (81.2 %, 82/101) in fusA, followed by t127 (81.8 %, 45/55) in fusC, and t189 (27.6 %, 8/29) in fusB. Furthermore, all t002 harboring fusC were detected as ST5-MRSA-SCCmecII clones. This is the first report of fusA and fusB carrying S. aureus and linkage fusB and blaZ genes in FRSA isolated from food animal products. Taken together, the FRSA in food animals with different resistance determinants and spa types could pose a threat to public health. | Kim, Su-Jeong; Ali, Md. Sekendar; Kang, Hee-Seung; Moon, Bo-Youn; Hwang, Yu-Jeong; Yoon, Soon-Seek; Park, Seung-Chun; Lim, Suk-Kyung | Anim & Plant Quarantine Agcy, Bacterial Dis Div, 177 Hyeoksin 8 Ro, Gimcheon Si 39660, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu, South Korea | Park, Seung-Chun/AAV-3388-2021 | 57211871623; 57219661221; 58782876300; 57209452048; 58843819700; 9838890500; 59260415700; 35086548900 | imsk0049@korea.kr; | INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY | INT J FOOD MICROBIOL | 0168-1605 | 1879-3460 | 430 | SCIE | FOOD SCIENCE & TECHNOLOGY;MICROBIOLOGY | 2024 | 5.2 | 16.3 | 0 | 2025-05-07 | 0 | 0 | Carcasses; bla operon; Insertion sequence; Mutations; spa types | METHICILLIN-RESISTANT; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL RESISTANCE; VIRULENCE FACTORS; NASAL CARRIAGE; CLONES; MEAT; PREVALENCE; WORKERS; SPREAD | bla operon; Carcasses; Insertion sequence; Mutations; spa types | Animals; Anti-Bacterial Agents; Cattle; Chickens; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Food Microbiology; Fusidic Acid; Microbial Sensitivity Tests; Republic of Korea; Staphylococcal Infections; Staphylococcus aureus; Swine; cefoxitin; chloramphenicol; ciprofloxacin; clindamycin; dalfopristin plus quinupristin; erythromycin; fusidic acid; gentamicin; kanamycin; linezolid; mupirocin; penicillin derivative; rifampicin; sulfamethoxazole; tetracycline; trimethoprim; vancomycin; antiinfective agent; fusidic acid; agar dilution; animal food; antibiotic resistance; Article; bacterial chromosome; bacterial gene; bacterium isolate; blaZ gene; bovine; broth dilution; carcass; controlled study; fusA gene; fusB gene; fusC gene; Gallus gallus; gene identification; gene insertion sequence; gene mutation; methicillin resistant Staphylococcus aureus; molecular phylogeny; multidrug resistance; nonhuman; operon; penicillin resistance; pig; polymerase chain reaction; South Korea; Staphylococcus aureus; animal; drug effect; epidemiology; food control; Gallus gallus; genetics; microbial sensitivity test; microbiology; South Korea; Staphylococcus infection; veterinary medicine | English | 2025 | 2025-02-16 | 10.1016/j.ijfoodmicro.2024.111026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigating the Allelopathic and Bioherbicidal Potential of Solidago altissima with a Focus on Chemical Signaling in Trifolium repens | Invasive weed species exhibit both advantages, such as the potential for allelochemicals in bioherbicide development, and risks, including their threat to crop production. Therefore, this study aims to identify an allelochemical from Solidago altissima, an invasive weed species. The dose-dependent effects of S. altissima shoot and root extracts (SSE, SRE) on the signaling in the forage crop Trifolium repens and germination in various weed species (Echinochloa oryzicola, Cyperus microiria, Alopecurus aequalis, Portulaca oleracea, and Amaranthus retroflexus) were evaluated. The results showed that the T. repens seedlings treated with root extracts exhibited a significant decrease in plant height, dry weight, and chlorophyll content, along with an increase in H2O2 levels. Additionally, antioxidant activities, such as superoxide dismutase, catalase, and peroxidase enzyme activities, were significantly elevated in T. repens treated with SRE. Moreover, SRE treatment significantly inhibited the seed germination of all tested weed species in a concentration-dependent manner. Gas chromatography-mass spectrometry analysis of S. altissima root extract identified a high concentration of methyl kolavenate, a clerodane diterpene predicted to act as a phytotoxic agent. These findings highlight the potential of S. altissima for the development of crop-protective agents while emphasizing its potential risks in agriculture. | Gam, Ho-Jun; Adhikari, Arjun; Kang, Yosep; Injamum-Ul-Hoque, Md.; Shaffique, Shifa; Woo, Ji-In; Jeon, Jin Ryeol; An, Byeong-Kwan; Back, Min Young; Kim, Ki-Yong; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Natl Inst Anim Sci, Rural Dev Adm RDA, Cheonan 31000, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | An, Byeong-Kwan/N-9488-2015; Lee, In-Jung/GLS-0432-2022; Gam, Hojun/MXJ-6421-2025; Adhikari, Arjun/AAV-6297-2021; Injamum-Ul-Hoque/ADJ-9141-2022; shaffique, shifa/KUC-7102-2024; Kang, Sang-Mo/MBG-7823-2025 | 57450591400; 57195601415; 57224404010; 58663974700; 57203898867; 58295960600; 58781998600; 59507444600; 59507231200; 57211349597; 56189696900; 16425830900 | 2023001144@knu.ac.kr; arjun@knu.ac.kr; alfm4545@knu.ac.kr; mdinjamum92@knu.ac.kr; shifa.2021@knu.ac.kr; wjxsj99@knu.ac.kr; 98micael@knu.ac.kr; abkabk1020@knu.ac.kr; miny4310@knu.ac.kr; kimky77@korea.kr; sangmo@knu.ac.kr; ijlee@knu.ac.kr; | PLANTS-BASEL | PLANTS-BASEL | 2223-7747 | 14 | 1 | SCIE | PLANT SCIENCES | 2024 | 4.1 | 16.3 | 0 | 2025-05-07 | 0 | 0 | phytotoxicity; weeds; ROS; antioxidants; phytohormone; methyl kolavenate | CLERODANE DITERPENOIDS; ANTIMICROBIAL ACTIVITY; ABSCISIC-ACID; STRESS; PHYTOHORMONES; LEAVES; SALICYLATE; EVOLUTION; JASMONATE | antioxidants; methyl kolavenate; phytohormone; phytotoxicity; ROS; weeds | English | 2025 | 2025-01 | 10.3390/plants14010096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Unraveling the Complexities of Flowering in Ornamental Plants: The Interplay of Genetics, Hormonal Networks, and Microbiome | In ornamental plants, one of the most complex life processes, i.e., flowering, is regulated by interaction between the microbiota, hormones, and genes. Flowering plays an integral role in overall development and is quintessential for reproduction. Considering its importance, this review explores the complex mechanisms that determine the induction of flowering, highlighting the relationship between hormonal and genetic networks as well as the growing significance of the microbiome. Important genes involved in genetic control include FT, SOC1, and LFY. These genes react to environmental stimuli like photoperiod and vernalization. Auxins, cytokinin, and gibberellins are only a few hormone pathways important for floral growth and timing. The importance of plant-microbe interactions has been emphasized by current research, which shows that the microbiome affects flowering through processes like hormone production and availability of food. A comprehensive understanding of flowering induction is possible by integrating results from microbiota, hormones, and genetics studies, which may improve the breeding and culture of ornamental plants. For researchers to understand the complexity of flowering in ornamental plants and develop unique breeding strategies and improved floral qualities, it is critical to use interdisciplinary approaches, as this comprehensive investigation demonstrates. | Aizaz, Muhammad; Hashmi, Syed Salman; Khan, Muhammad Aaqil; Jan, Rahmatullah; Bilal, Saqib; Kim, Kyung-Min; Al-Harrasi, Ahmed; Asaf, Sajjad | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Qurtaba Univ Sci & Technol, Dept Chem & Life Sci, Peshawar 25000, Pakistan; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Khan, Muhammad/ABB-9797-2021; Jan, Rahmatullah/AIC-3439-2022; Ul-Hamid, Anwar/B-7297-2015; Asaf, Sajjad/ABA-3647-2021 | 57224641342; 57200621537; 59714943200; 57188585606; 57201981969; 57031617400; 34868260300; 6506093146; 56595059900 | aqil_bacha@yahoo.com; kkm@knu.ac.kr; sajadasif2000@gmail.com; | PLANTS-BASEL | PLANTS-BASEL | 2223-7747 | 14 | 7 | SCIE | PLANT SCIENCES | 2024 | 4.1 | 16.3 | 0 | 2025-05-07 | 0 | 0 | plant microbiome interaction; flower induction; FT; SOC1; LFY genes; plant hormones | LOCUS-T; FUNCTIONAL-ANALYSIS; CIRCADIAN-RHYTHMS; FLORAL TRANSITION; GROWTH-REGULATORS; BACILLUS-SUBTILIS; ABSCISIC-ACID; GIBBERELLIN; ARABIDOPSIS; VERNALIZATION | flower induction; FT; LFY genes; plant hormones; plant microbiome interaction; SOC1 | English | 2025 | 2025-04-06 | 10.3390/plants14071131 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fabrication of blue-emitting CH3NH3PbBr3 nanocrystals: Effects of dipole moment and oxygen functional groups in precipitation solvents on the crystal growth and optical properties of CH3NH3PbBr3 nanocrystals | In this study, blue-emitting CH3NH3PbBr3 nanocrystals (NCs) were achieved by changing the precipitation solvent used in ligand-assisted re-precipitation (LARP) process from a non-polar to a polar solvent. As the dipole moment of precipitation solvent (Sol. B) with oxygen functional groups increased, the photoluminescence (PL) spectrum of CH3NH3PbBr3 NCs was blue-shifted and the crystal size decreased. The high dipole moment of Sol. B increased the interaction between the ligands and Sol. B, promoting the growth of CH3NH3PbBr3 bulk particles rather than CH3NH3PbBr3 NCs. This decreased the monomer concentration in the reaction vessel, thereby limiting the crystal growth of CH3NH3PbBr3 NCs. This study demonstrates that blue-emitting CH3NH3PbBr3 NCs can be achieved by controlling the interaction between the ligands and Sol. B through variations in the dipole moment of Sol. B, and that the presence of oxygen functional groups is essential for tuning the optical bandgap of CH3NH3PbBr3 NCs. | Kim, Dokyum; Park, Seong-On; Park, Jung Su; Byeon, Clare C.; Lee, Chang-Lyoul | Gwangju Inst Sci & Technol GIST, Adv Photon Res Inst APRI, Gwangju 61005, South Korea; Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Sci & Technol, Dept Smart Mobil Engn, Daegu 41566, South Korea | 57212308311; 59514070800; 59513669100; 55987812100; 57196254178 | byeon@knu.ac.kr; vsepr@gist.ac.kr; | JOURNAL OF COLLOID AND INTERFACE SCIENCE | J COLLOID INTERF SCI | 0021-9797 | 1095-7103 | 693 | SCIE | CHEMISTRY, PHYSICAL | 2024 | 9.7 | 16.5 | 0 | 2025-05-07 | 0 | 0 | PEROVSKITE QUANTUM DOTS; LUMINESCENT; CSPBX3; METAL; BR; CL | Blue shift; Nanocrystals; Photoluminescence spectroscopy; nanocrystal; functional group; monomer; oxygen; solvent; Blue-emitting; NH 3; Non-polar; Optical-; Oxygen functional groups; Photoluminescence spectrum; Polar solvents; Precipitation process; Property; Re-precipitation; Article; bulk density; chemical structure; controlled study; crystal structure; crystallization; dielectric constant; dipole; field emission scanning electron microscopy; high resolution transmission electron microscopy; hydrogen bond; photoluminescence; precipitation; proton nuclear magnetic resonance; article; dipole; drug development; optics; Ligands | English | 2025 | 2025-09 | 10.1016/j.jcis.2025.137530 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Simultaneous extraction and dissolution in surface nanodroplets for controlling the crystallization of small organic molecules | Droplets have been widely used for studying crystallization reactions which are difficult to control in the bulk. Most crystallization studies, however, rely on the evaporation or dissolution of the droplet liquid to achieve crystal growth, but it is difficult to control the crystallization process due to the uneven evaporation flux around the droplet. Here we show a new method for inducing and controlling the crystallization of organic molecules from an unsaturated solution using surface nanodroplets. Our method achieves crystallization by inducing liquid-liquid extraction of the organic molecules from its aqueous solution into surface nanodroplets. Concurrently, the surface nanodroplets slowly dissolve due to the continuous flowing aqueous stream. The synergy between liquid-liquid extraction and droplet dissolution drives supersaturation inside the surface nanodroplet that ultimately leads to nucleation and crystallization of organic molecules. The influence of molecule concentration and solution flow rate is investigated by tuning these parameters independently. Using trimesic acid (TMA) as model compound, we show that faster crystallization is achieved at higher TMA concentration, attributable to the higher driving force for diffusion of TMA into the surface nanodroplets. Additionally, thinner crystals are observed at higher solution flow rates, mainly due to a thinner concentration boundary layer around the surface nanodroplet which enables faster transport of TMA into the droplet. The method shown in this work can potentially be used in the formation of single crystals which is important in many areas including semiconductors, pharmaceuticals, and energy devices. | Lim, Eunmin; Kim, Dan Ah; You, Jae Bem | Kyungpook Natl Univ, Sch Chem Engn & Appl Chem, Dept Chem Engn, Daegu 41566, South Korea; Chungnam Natl Univ, Dept Chem Engn & Appl Chem, Daejeon 34134, South Korea | You, Jae/C-6211-2019 | 58176307200; 59322617900; 55619455300 | jb.you@cnu.ac.kr; | JOURNAL OF COLLOID AND INTERFACE SCIENCE | J COLLOID INTERF SCI | 0021-9797 | 1095-7103 | 691 | SCIE | CHEMISTRY, PHYSICAL | 2024 | 9.7 | 16.5 | 0 | 2025-05-07 | 0 | 0 | Surface nanodroplets; Crystallization; Liquid-liquid extraction; Supersaturation | SINGLE-DROP; MICROEXTRACTION; SOLUBILITY | Crystallization; Liquid–liquid extraction; Supersaturation; Surface nanodroplets | Solvent extraction; nanoparticle; octanol; water; Crystallization process; Crystallization reaction; Liquid-liquid extraction; Nano-droplets; Organic molecules; Simultaneous extractions; Small organic molecules; Solution flow rate; Surface nanodroplet; Trimesic acid; aqueous solution; Article; boundary layer; concentration (parameter); controlled study; crystal; dissolution; field emission scanning electron microscopy; flow rate; laminar flow; liquid liquid extraction; nanotechnology; Raman spectrometry; solubility; surface property; article; crystallization; diffusion; evaporation; liquid; nonhuman; semiconductor; Supersaturation | English | 2025 | 2025-08 | 10.1016/j.jcis.2025.137378 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Transition metal doped pyrazine-graphyne for high-performance CO2 reduction reaction to C1 products | The pressing necessity to mitigate climate change and transition to a sustainable energy economy underscores the importance of developing highly efficient and selective catalysts for electrocatalytic CO2 reduction (CO2RR). This study explores nitrogen-doped graphyne (N-GY) as a promising substrate for anchoring 3d and 4d transition metal atoms (TMs), facilitating the creation of high-performance electrocatalysts. Through comprehensive computational analysis based on density functional theory (DFT), we provide a detailed understanding of the mechanisms involved in CO2 capture by these catalysts. Our results reveal a "donation-backdonation" mechanism during CO2 adsorption, characterized by significant charge transfer and orbital overlap, which enhance CO2 adsorption and activation. We identify ten catalysts exhibiting exceptional activity and selectivity, with V-S2@N- GY standing out for its ultra-low limiting potential of-0.279 V, which is particularly beneficial for carbon monoxide generation. The mechanistic analysis further underscores the critical role of the *COOH intermediate adsorption strength in dictating CO2RR activity. This study provides valuable theoretical insights for the design and optimization of efficient CO2RR catalysts. | Ma, Rongwei; Yang, Yuejiao; Wei, Xinru; Cho, Daeheum; Lee, Jin Yong; Kang, Baotao | Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China; Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | KANG, Baotao/F-2444-2015 | 59805969300; 58942293300; 58520496200; 55263218400; 24478458000; 37032828500 | daeheumc@knu.ac.kr; jinylee@skku.edu; chm_kangbt@ujn.edu.cn; | JOURNAL OF COLLOID AND INTERFACE SCIENCE | J COLLOID INTERF SCI | 0021-9797 | 1095-7103 | 689 | SCIE | CHEMISTRY, PHYSICAL | 2024 | 9.7 | 16.5 | 0 | 2025-05-07 | 1 | 1 | Single-atom catalysts; Density functional theory; Donation-backdonation; Volcano plot; CO2 reduction reaction | ELECTROCHEMICAL CO2; CATALYSTS | CO<sub>2</sub> reduction reaction; Density functional theory; Donation-backdonation; Single-atom catalysts; Volcano plot | Carbon monoxide; Oxygen reduction reaction; Vanadium compounds; carbon dioxide; carbon monoxide; nitrogen; pyrazine; transition element; nitrogen; Back-donation; CO 2 reduction; CO2 reduction reaction; Density-functional-theory; Donation-backdonation; Reduction reaction; Single-atom catalyst; Single-atoms; Volcano plots; ]+ catalyst; adsorption; Article; catalyst; density functional theory; electrocatalysis; reaction analysis; reduction (chemistry); article; atom; climate change; controlled study; density functional theory; electric potential; volcano | English | 2025 | 2025-07 | 10.1016/j.jcis.2025.03.037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation | Background: Our Kaplan–Meier analysis reveals that gastric cancer patients with high androgen receptor (AR) expression demonstrate poorer survival outcomes compared to those with low AR expression, particularly in patients with characteristics typical of EBV-positive gastric cancer. However, the molecular mechanisms driving this seemingly contradictory relationship have remained poorly understood, as our experimental findings suggest AR signaling actually suppresses tumor growth in EBVaGC. Methods: The study utilized AR-positive EBV-infected gastric cancer cell lines treated with dihydrotestosterone (DHT) to investigate molecular pathways. Comprehensive analyses included examination of apoptosis, miRNA expression, signaling pathways, DNA methylation patterns, and viral gene expression. In vivo validation was performed using xenograft models with MKN1-EBV and SNU719 cells to assess tumor growth and immune response. Results: DHT treatment triggered early apoptosis through upregulation of pro-apoptotic miRNAs, particularly miR-204-5p, while activating the PI3K-Akt pathway and enhancing DNA damage response through increased phosphorylation of key proteins. The treatment reduced DNMT3A expression, leading to genome-wide DNA demethylation and increased expression of both lytic (BZLF1) and latent (EBNA1, LMP1) EBV genes. Xenograft studies confirmed these findings, showing reduced tumor growth, increased lymphocyte infiltration, and enhanced viral gene expression specifically in AR-positive tumors. Conclusion: The study reveals that AR signaling suppresses EBV-positive gastric cancer by modulating both cellular apoptosis and EBV reactivation through epigenetic mechanisms. These findings suggest that AR agonists might have therapeutic potential in treating AR-positive EBV-associated gastric cancer. © The Author(s) under exclusive licence to The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2025. | Cho, Miyeon; Byun, Hyeji; Lee, Sun Hee; Youn, Sohyun; Jung, Inuk; Jung, Joohee; Lee, Junho; Cho, Hyosun; Kang, Hyojeung | Vessel-Organ Interaction Research Center, Healthcare Convergence Educational Group for Infectious Disease Management, Research Institute of Pharmaceutical Science, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South Korea; Vessel-Organ Interaction Research Center, Healthcare Convergence Educational Group for Infectious Disease Management, Research Institute of Pharmaceutical Science, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South Korea; Vessel-Organ Interaction Research Center, Healthcare Convergence Educational Group for Infectious Disease Management, Research Institute of Pharmaceutical Science, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South Korea; Department of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; Department of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; Duksung Innovative Drug Center, College of Pharmacy, Duksung Women’s University, Seoul, South Korea; Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea; Duksung Innovative Drug Center, College of Pharmacy, Duksung Women’s University, Seoul, South Korea; Vessel-Organ Interaction Research Center, Healthcare Convergence Educational Group for Infectious Disease Management, Research Institute of Pharmaceutical Science, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 702-701, South Korea | 57190213901; 59347283300; 58607352900; 59347828200; 56067575500; 8858539100; 57219032336; 55572361200; 8979751700 | hkang72@knu.ac.kr; | Gastric Cancer | GASTRIC CANCER | 1436-3291 | 1436-3305 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2024 | 5.1 | 16.7 | N/A | 0 | Androgen receptor; Dihydrotestosterone; DNA methylation; Epigenetic regulation; Epstein-Barr virus; Gastric cancer | English | Article in press | 2025 | 10.1007/s10120-025-01626-6 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma | BackgroundThe therapeutic effectiveness of cisplatin, a widely used chemotherapy drug for oral squamous cell carcinoma (OSCC), is often compromised by resistance, making it difficult to predict treatment outcomes. The role of myotubularin and myotubularin-related (MTMR) genes in cisplatin resistance remains unclear. We aimed to elucidate the molecular mechanisms underlying MTMR6 with cisplatin resistance in OSCC.MethodsMTMR6 expression was compared between UMSCC1 and cisplatin-resistant UM-Cis cells. Gain- and loss-of-function experiments involving MTMR6 was performed to evaluate its impact on cisplatin resistance. The regulatory role of hsa-miR-544a on MTMR6 expression was explored via antagomir and miRNA mimic assays. The relationship between MTMR6 protein levels and cisplatin sensitivity was assessed in OSCC patient tissues classified as sensitive or resistant to cisplatin monotherapy. A survival analysis based on The Cancer Genome Atlas (TCGA) head and neck squamous cell carcinoma (HNSCC) dataset was performed to evaluate the correlation between MTMR6 expression and patient outcomes following cisplatin treatment. In vivo cisplatin resistance was examined using mouse xenografts derived from MTMR6-knockdown UMSCC1 cells.ResultsMTMR6 expression was markedly reduced in cisplatin-resistant UM-Cis cells compared to UMSCC1 cells. Functional analyses revealed that modulating MTMR6 activity alters cisplatin resistance. A luciferase assay confirmed that hsa-miR-544a regulates MTMR6 gene expression. Additionally, antagomir and miRNA mimics demonstrated that hsa-miR-544a enhances cisplatin resistance by suppressing MTMR6 expression. In OSCC patient tissues, higher MTMR6 protein levels were associated with cisplatin sensitivity, while cisplatin-resistant tissues had lower MTMR6 expression. Survival analysis of the TCGA HNSCC dataset indicated that low MTMR6 expression correlates with poorer outcomes in cisplatin-treated patients compared to those with high MTMR6 expression. Mouse xenografts derived from MTMR6-knockdown UMSCC1 cells exhibited increased resistance to cisplatin compared to controls.ConclusionAssessing mRNA levels of MTMR6 and has-miR-544a in biopsy samples could help predict cisplatin responsiveness in OSCC. | Lee, Kah Young; Oh, Su Young; Lee, Heon-Jin; Kwon, Tae-Geon; Kim, Jin-Wook; Shin, Chang-Geol; Hong, Su-Hyung; Choi, So-Young | Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea | 57226450171; 57204016703; 36462383000; 35205433300; 55862646000; 59550575300; 8691449100; 57202918688 | christin_a@naver.com; oohsuy@knu.ac.kr; heonlee@knu.ac.kr; kwondk@knu.ac.kr; vocaleo@knu.ac.kr; jncg2718@gmail.com; hongsu@knu.ac.kr; dentalchoi@knu.ac.kr; | CANCER CELL INTERNATIONAL | CANCER CELL INT | 1475-2867 | 25 | 1 | SCIE | ONCOLOGY | 2024 | 6 | 16.7 | 3.96 | 2025-05-07 | 1 | 1 | Oral squamous cell carcinoma; Cisplatin resistance; OSCC organoid; Clinical tissues; MTMR6; Hsa-miR-544a | TUMOR MICROENVIRONMENT; MOLECULAR-MECHANISMS; CANCER; APOPTOSIS | Cisplatin resistance; Clinical tissues; Hsa-miR-544a; MTMR6; Oral squamous cell carcinoma; OSCC organoid | antagomir; caspase 3; cisplatin; hsa microRNA 544a; microRNA; myotubularin and myotubularin related protein 6; protein; small interfering RNA; unclassified drug; animal experiment; animal model; apoptosis; Article; cell viability; controlled study; down regulation; drug sensitivity; enzyme linked immunosorbent assay; gene expression; gene overexpression; genetic transfection; human; human cell; human tissue; immunofluorescence; immunohistochemistry; luciferase assay; male; mouse; mouth squamous cell carcinoma; MTT assay; nonhuman; organoid; protein expression; real time polymerase chain reaction; SCC-15 cell line; survival analysis; tumor volume; UM-SCC-1 cell line; Western blotting | English | 2025 | 2025-01-31 | 10.1186/s12935-025-03654-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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