2023 연구성과 (6 / 285)

※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo Background: The anti-platelet activity of the saponin fraction of Korean Red Ginseng has been widely studied. The saponin fraction consists of the panaxadiol fraction (PDF) and panaxatriol fraction (PTF); however, their anti-platelet activity is yet to be compared. Our study aimed to investigate the potency of anti-platelet activity of PDF and PTF and to elucidate how well they retain their anti-platelet activity via different administration routes. Methods: For ex vivo studies, Sprague-Dawley rats were orally administered 250 mg/kg PDF and PTF for 7 consecutive days before blood collection via cardiac puncture. Platelet aggregation was conducted after isolation of the washed platelets. For in vitro studies, washed platelets were obtained from SpragueDawley rats. Collagen and adenosine diphosphate (ADP) were used to induce platelet aggregation. Collagen was used as an agonist for assaying adenosine triphosphate release, thromboxane B2, serotonin, cyclic adenosine monophosphate, and cyclic guanosine monophosphate (cGMP) release. Results: When treated ex vivo, PDF not only inhibited ADP and collagen-induced platelet aggregation, but also upregulated cGMP levels and reduced platelet adhesion to fibronectin. Furthermore, it also inhibited Akt phosphorylation induced by collagen treatment. Panaxadiol fraction did not exert any antiplatelet activity in vitro, whereas PTF exhibited potent anti-platelet activity, inhibiting ADP, collagen, and thrombin-induced platelet aggregation, but significantly elevated levels of cGMP. Conclusion: Our study showed that in vitro and ex vivo PDF and PTF treatments exhibited different potency levels, indicating possible metabolic conversions of ginsenosides, which altered the content of ginsenosides capable of preventing platelet aggregation. (c) 2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Lee, Yuan Yee; Oh, Yein; Seo, Min-Soo; Seo, Min-Goo; Han, Jee Eun; Kim, Kyoo-Tae; Park, Jin-Kyu; Kim, Sung Dae; Park, Sang-Joon; Kwak, Dongmi; Rhee, Man Hee Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Univ Maryland, Dept Anim & Avian Sci, College Pk, MD USA; Cardiovasc Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016; Seo, Min-Goo/NQF-4335-2025 57203798815; 36466903200; 35254332100; 53982155300; 57214671240; 56680415000; 35213723500; 55156746000; 7501825941; 7007148758; 57211035357 rheemh@knu.ac.kr; JOURNAL OF GINSENG RESEARCH J GINSENG RES 1226-8453 2093-4947 47 5 SCIE CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE 2023 6.8 1.2 0.4 2025-06-25 2 2 Panax ginseng; panaxatriol fraction; platelet aggregation; Korean Red Ginseng PLATELET ACTIVATION; METABOLISM; GINSENOSIDES; RB-1 Korean Red Ginseng; Panax ginseng; panaxatriol fraction; platelet aggregation acetylsalicylic acid; adenosine diphosphate; adenosine triphosphate; antithrombocytic agent; calcium ion; collagen; cyclic AMP; cyclic GMP; fibronectin; ginsenoside; mitogen activated protein kinase; panaxadiol; panaxatriol; phosphatidylinositol 3 kinase; protein kinase B; saponin derivative; serotonin; stress activated protein kinase; thrombin; thromboxane B2; unclassified drug; animal experiment; antiplatelet activity; Article; blood sampling; calcium mobilization; cardiac puncture; controlled study; drug potency; enzyme phosphorylation; ex vivo study; fractionation; ginseng; in vitro study; male; MAPK signaling; nonhuman; Pi3K/Akt signaling; protein expression; rat; serotonin level; serotonin release; thrombocyte adhesion; thrombocyte aggregation; upregulation; Western blotting English 2023 2023-09 10.1016/j.jgr.2023.03.003 바로가기 바로가기 바로가기 바로가기
Meeting Abstract THE CASE OF AGGRESSIVE DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR IN ADULT TREATED WITH CRANIOSPINAL IRRADIATION AND TEMOZOLOMIDE Hwang, J.; Lee, C.; Yoon, S.; Kim, M.; Park, K.; Park, S. Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Univ Ulsan, Coll Med, Dept Neurosurg, Asan Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea NEURO-ONCOLOGY NEURO-ONCOLOGY 1522-8517 1523-5866 25 SCIE CLINICAL NEUROLOGY;ONCOLOGY 2023 16.4 1.2 0 English 2023 2023-09 10.1093/neuonc/noad137.382 바로가기 바로가기 바로가기
Meeting Abstract The efficacy and safety of radiation-free retrograde intrarenal surgery: A prospective multicenter-based randomized controlled study Lee, S. H.; Kang, J. H.; J-K, Kang; J-W, Chung; Y-S, Ha; Choi, S. H.; Lee, J. N.; Kim, H. T.; T-H, Kim; Yoo, E. S.; Kwon, T. G.; Jung, W. H.; Oh, K. J.; Kim, H. W.; Shin, D. G.; Kim, B. S. Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Keimyung Univ, Dept Urol, Sch Med, Daegu, South Korea; Chonnam Natl Univ, Sch Med, Dept Urol, Kwangju, South Korea; Pusan Natl Univ, Sch Med, Dept Urol, Pusan, South Korea Kim, Soo-Yeon/ADR-9663-2022 EUROPEAN UROLOGY EUR UROL 0302-2838 1873-7560 83 SCIE UROLOGY & NEPHROLOGY 2023 25.3 1.2 0 English 2023 2023-02 바로가기 바로가기
Article Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably in-duces poorly understood global changes in GBM and its microenvironment (TME) that promote radio -resistance and recurrence. Through a cell surface marker screen, we identified that CD142 (tissue factor or F3) is robustly induced in the senescence-associated b-galactosidase (SA-bGal)-positive GBM cells after irradiation. F3 promotes clonal expansion of irradiated SA-bGal+ GBM cells and orchestrates oncogenic TME remodeling by activating both tumor-autonomous signaling and extrinsic coagulation pathways. Intratumoral F3 signaling induces a mesenchymal-like cell state transition and elevated chemokine secretion. Simultaneously, F3 -mediated focal hypercoagulation states lead to activation of tumor-associated macrophages (TAMs) and extracellular matrix (ECM) remodeling. A newly developed F3-targeting agent potently inhibits the aforementioned oncogenic events and impedes tumor relapse in vivo. These findings support F3 as a critical regulator for therapeutic resistance and oncogenic senescence in GBM, opening potential therapeutic avenues. Jeon, Hye-Min; Kim, Jeong-Yub; Cho, Hee Jin; Lee, Won Jun; Nguyen, Dayna; Kim, Sung Soo; Oh, Young Taek; Kim, Hee-Jin; Hubert, Christopher G.; Jung, Chan-Woong; Pinero, Gonzalo; Joshi, Tanvi; Sakaguchi, Takuya; Hambardzumyan, Dolores; Mcintyre, Thomas M.; Fine, Howard A.; Gladson, Candece L.; Wang, Bingcheng; Purow, Benjamin W.; Park, Jong Bae; Park, Myung Jin; Nam, Do-Hyun; Lee, Jeongwu Cleveland Clin, Dept Canc Biol, Lerner Res Inst, Cleveland, OH 44195 USA; Korea Inst Radiol & Med Sci, Res Ctr Radiosenescence, Div Radiat Canc Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Syst Canc Sci, Goyang, South Korea; Icahn Sch Med Mt Sinai, New York, NY USA; Cleveland Clin, Dept Inflammat & Immun, Lerner Res Inst, Cleveland, OH USA; Cleveland Clin, Lerner Res Inst, Dept Biomed Engn, Cleveland, OH USA; Cleveland Clin, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA; Weill Cornell, Dept Neurol, New York, NY USA; Case Western Reserve Univ, Sch Med, Dept Med, MetroHealth Campus, Cleveland, OH 44106 USA; Univ Virginia Hlth Syst, UVA Canc Ctr, Dept Neurol, Charlottesville, VA USA; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Samsung Med Ctr,Dept Neurosurg,Sch Med, Dept Hlth Sci & Technol,Inst Refractory Canc Res,, Seoul, South Korea Kim, Seok-Hwan/G-9981-2015; Oh, Young Taek/HTQ-8764-2023; Kim, HJ/HHT-1389-2022; Park, Jinkyeong/GLV-1649-2022 56222840200; 55264584300; 55937716400; 58164112900; 57894743900; 57203773276; 57198404875; 57218261085; 57216330999; 59428568800; 57683933800; 15122025700; 36744602100; 56622478300; 7102225623; 7006606728; 7004695875; 56019851000; 6508182475; 58599784300; 15127646900; 57190971869; 55689973000 leej7@ccf.org; CANCER CELL CANCER CELL 1535-6108 1878-3686 41 8 SCIE CELL BIOLOGY;ONCOLOGY 2023 48.8 1.2 6.2 2025-06-25 41 41 GENE-EXPRESSION; STEM-CELLS; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; CANCER; CULTURE; TEMOZOLOMIDE; PROGRESSION; BEVACIZUMAB; HEMOSTASIS glioblastoma; senescence; therapeutic resistance; tissue factor; tumor microenvironment Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Neoplasm Recurrence, Local; Signal Transduction; Thromboplastin; Tumor Microenvironment; beta galactosidase; blood clotting factor; caspase 3; CD163 antigen; chemokine; chitinase 3 like protein 1; fibrin; fibronectin; fibronectin 1; Hermes antigen; immunoglobulin enhancer binding protein; integrin; radiosensitizing agent; recombinant blood clotting factor 7; recombinant protein; STAT3 protein; temozolomide; thromboplastin; unclassified drug; thromboplastin; animal experiment; animal model; animal tissue; Article; blood clotting; cancer inhibition; cancer radiotherapy; cancer signaling; carcinogenesis; cell aging; cell expansion; cell survival; chemoradiotherapy; clonal evolution; controlled study; cytokine release; drug potency; drug targeting; extracellular matrix; glioblastoma; human; human cell; human tissue; hypercoagulability; IMR-90 cell line; in vivo study; intracellular signaling; irradiation; M2 tumor-associated macrophage; mouse; NF kB signaling; nonhuman; normal human; nuclear reprogramming; progression free survival; radiation response; radiosensitivity; radiosensitization; regulatory mechanism; senescence-associated secretory phenotype; tumor microenvironment; tumor recurrence; tumor-associated macrophage; WI-38 cell line; brain tumor; genetics; glioblastoma; metabolism; signal transduction; tumor cell line English 2023 2023-08-14 10.1016/j.ccell.2023.06.007 바로가기 바로가기 바로가기 바로가기
Article Adult asthma with symptomatic eosinophilic inflammation is accompanied by alteration in gut microbiome BackgroundAccumulating evidence suggests that the gut microbiome is associated with asthma. However, altered gut microbiome in adult asthma is not yet well established. We aimed to investigate the gut microbiome profiles of adult asthmatic patients with symptomatic eosinophilic inflammation. MethodsThe 16 s rRNA gene metagenomic analysis of feces in the symptomatic eosinophilic asthma group (EA, n = 28) was compared with the healthy control (HC, n = 18) and the chronic cough control (CC, n = 13). A correlation analysis between individual taxa and clinical markers was performed within the EA group. Changes in the gut microbiome were examined in patients with significant symptom improvement in the EA group. ResultsThe relative abundances of Lachnospiraceae and Oscillospiraceae significantly decreased and Bacteroidetes increased in the EA group. Within EA group, Lachnospiraceae was negatively correlated with indicators of type 2 inflammation and lung function decline. Enterobacteriaceae and Prevotella was positively associated with type 2 inflammation and lung function decline, respectively. The abundance of predicted genes associated with amino acid metabolism and secondary bile acid biosynthesis was diminished in the EA group. These functional gene family alterations could be related to gut permeability, and the serum lipopolysaccharide concentration was actually high in the EA group. EA patients with symptom improvement after 1 month did not show a significant change in the gut microbiome. ConclusionsSymptomatic eosinophilic adult asthma patients showed altered the gut microbiome composition. Specifically, a decrease in commensal clostridia was observed, and a decrease in Lachnospiraceae was correlated with blood eosinophilia and lung function decline. Gu, Bon-Hee; Choi, Jun-Pyo; Park, Tansol; Kim, A-Sol; Jung, Ho Young; Choi, Doo Young; Lee, Sang Jin; Chang, Yoon-Seok; Kim, Myunghoo; Park, Han-Ki Pusan Natl Univ, Life & Ind Convergence Res Inst, Miryang, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam Si, South Korea; Chung Ang Univ, Dept Anim Sci & Technol, Anseong, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Family Med, Deagu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Allergy & Clin Immunol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Anim Sci, Miryang Si, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Allergy & Clin Immunol, 807 Hoguk Ro, Daegu, South Korea; Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Anim Sci, Miryang Si 50463, South Korea Park, Han-Ki/AAY-3102-2020; Chang, Yoon-Seok/J-5628-2012; Choi, Jun-Pyo/HHN-0690-2022 26537340600; 34867798100; 57193064799; 57203290656; 58150960400; 58151576900; 57192516055; 55712986100; 36611749600; 57218664064 kimmhmm3@gmail.com;haan33@gmail.com; ALLERGY ALLERGY 0105-4538 1398-9995 78 7 SCIE ALLERGY;IMMUNOLOGY 2023 12.6 1.3 1.74 2025-06-25 13 12 adult; asthma; eosinophils; gut microbiome CELLS; MILD adult; asthma; eosinophils; gut microbiome Adult; Asthma; Gastrointestinal Microbiome; Humans; Inflammation; Metagenome; Pulmonary Eosinophilia; RNA, Ribosomal, 16S; antihistaminic agent; bile acid; corticosteroid; ketamine; leukotriene receptor blocking agent; lipopolysaccharide; RNA 16S; xylazine; adult; amino acid metabolism; animal experiment; animal model; Article; asthma; Bacteroidetes; biosynthesis; chronic cough; clinical article; clinical indicator; controlled study; correlation analysis; Enterobacteriaceae; eosinophilia; eosinophilic asthma; feces; female; follow up; forced expiratory volume; forced vital capacity; fractional exhaled nitric oxide; human; intestine flora; Lachnospiraceae; lung function; male; metagenomics; microbial community; microbial diversity; mouse; multigene family; nonhuman; Prevotella; respiratory tract inflammation; Shannon index; taxonomy; genetics; inflammation; metagenome; pulmonary eosinophilia English 2023 2023-07 10.1111/all.15691 바로가기 바로가기 바로가기 바로가기
Letter An artificial intelligence algorithm-based smartphone application for daily cough monitoring Shim, Ji-Su; Kim, Min-Hye; Lee, Sang Min; Kim, Sae-Hoon; Kwon, Jae-Woo; Song, Catherine; Ahn, Kyung-Min; Kang, Sung-Yoon; Park, Han-Ki; Park, Heung-Woo; Kim, Byung-Keun; Yang, Min-Suk Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; Soundable Hlth Inc, San Francisco, CA USA; SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Coll Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea; SMG SNU Boramae Med Ctr, Dept Internal Med, 20 Boramae Ro 5 gil, Seoul 07061, South Korea Kim, Byung-Keun/N-4256-2018; Kim, Sae/AAR-3907-2020; Kim, Hye/AAF-7609-2020; Kang, Sung-Yoon/AAG-7523-2020; Park, Han-Ki/AAY-3102-2020; Lee, Sang/J-5579-2012; Park, Heung-Woo/AAW-7690-2020 57193221759; 58045929900; 55913470000; 35198322400; 57204538197; 57357385300; 55421364200; 55492809000; 57218664064; 7601567361; 36608393400; 7404927140 htgskbk@gmail.com;msyangmd@gmail.com; ALLERGY ALLERGY 0105-4538 1398-9995 78 5 SCIE ALLERGY;IMMUNOLOGY 2023 12.6 1.3 2.62 2025-06-25 5 6 Algorithms; Artificial Intelligence; Cough; Humans; Smartphone; algorithm; artificial intelligence; coughing; human; Letter; sensitivity and specificity; visual analog scale; algorithm; coughing English 2023 2023-05 10.1111/all.15632 바로가기 바로가기 바로가기 바로가기
Meeting Abstract Characteristic analysis of asthmatic airflow using computed tomography images incorporating computational fluid dynamics Kim, S. R.; Hung, N. Quoc; Chae, K. J.; Jin, G. Y.; Choi, S. Jeonbuk Natl Univ, Med Sch, Jeonju, South Korea; Kyungpook Natl Univ, Daegu, South Korea ALLERGY ALLERGY 0105-4538 1398-9995 78 SCIE ALLERGY;IMMUNOLOGY 2023 12.6 1.3 0 English 2023 2023-12 바로가기 바로가기
Meeting Abstract Exosome from IFN-γ primed induced pluripotent stem cell-derived mesenchymal stem cells ameliorate atopic dermatitis in a murine model Yu, J.; Yoon, J.; Lee, S. K.; Park, A.; Lee, J.; Jung, I; Song, K. B.; Choi, E. J.; Kim, S. Asan Med Ctr, Seoul, South Korea; Brexogen Inc, Seoul, South Korea; Kyungpook Natl Univ, Daegu, South Korea Jung, Inkyung/Q-2018-2016 ALLERGY ALLERGY 0105-4538 1398-9995 78 SCIE ALLERGY;IMMUNOLOGY 2023 12.6 1.3 0 English 2023 2023-02 바로가기 바로가기
Article Lane Change-Intention Inference and Trajectory Prediction of Surrounding Vehicles on Highways The behavior prediction of the surrounding vehicles is crucial when planning a minimal-risk path when realizing a collision-avoidance system. Herein, we propose a multiple model-based adaptive estimator (MMAE) that infers the lane-change intention of the surrounding vehicles and then predicts their trajectories. Specifically, first, a path is generated in the form of a cubic spline curve using the Frenet coordinate system, which is robust to changes in road curvatures. Linearized recursive least-squares estimation (LRLSE) method is used to adaptively predict a future trajectory based on the past trajectory of the target vehicle. Preview time is defined as a time-varying parameter that determines the final point of the path, and LRLSE updates it in real time. The MMAE applies LRLSEs to multiple paths and obtains the mode probability for each path, then the lane-change intention is inferred using the mode probability and preview time. The predicted future trajectory is the cubic spline curve determined based on the preview time. Further, we verify the performance of our approach using highD, a naturalistic dataset of vehicle trajectories, and compare it with those of existing methods. The proposed method does not require a large amount of data for training and has a low computational burden and high real-time performance. Do, Jongyong; Han, Kyoungseok; Choi, Seibum B. B. Korea Adv Inst Sci & Technol, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea 58072413800; 56465294700; 7408122825 djy0129@kaist.ac.kr;kyoungsh@knu.ac.kr;sbchoi@kaist.ac.kr; IEEE TRANSACTIONS ON INTELLIGENT VEHICLES IEEE T INTELL VEHICL 2379-8858 2379-8904 8 7 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, ELECTRICAL & ELECTRONIC;TRANSPORTATION SCIENCE & TECHNOLOGY 2023 14 1.3 3.22 2025-06-25 22 25 Lane-change intention; linearized recursive least-squares estimation; multiple model-based adaptive estimator; trajectory prediction MODEL; AVOIDANCE Lane-change intention; linearized recursive least-squares estimation; multiple model-based adaptive estimator; trajectory prediction Curve fitting; Forecasting; Intelligent systems; Intelligent vehicle highway systems; Interpolation; Least squares approximations; Linearization; Vehicles; Adaptive estimators; Cubic spline curve; Lane change; Lane-change intention; Linearized recursive least-square estimation; Model-based OPC; Multiple model-based adaptive estimator; Multiple-modeling; Recursive least-squares estimation; Trajectory prediction; Trajectories English 2023 2023-07 10.1109/tiv.2023.3266102 바로가기 바로가기 바로가기 바로가기
Article Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis Mitochondrial components have been abundantly detected in bone matrix, implying that they are somehow transported extracellularly to regulate osteogenesis. Here, we demonstrate that mitochondria and mitochon-drial-derived vesicles (MDVs) are secreted from mature osteoblasts to promote differentiation of osteopro-genitors. We show that osteogenic induction stimulates mitochondrial fragmentation, donut formation, and secretion of mitochondria through CD38/cADPR signaling. Enhancing mitochondrial fission and donut formation through Opa1 knockdown or Fis1 overexpression increases mitochondrial secretion and acceler-ates osteogenesis. We also show that mitochondrial fusion promoter M1, which induces Opa1 expression, impedes osteogenesis, whereas osteoblast-specific Opa1 deletion increases bone mass. We further demon-strate that secreted mitochondria and MDVs enhance bone regeneration in vivo. Our findings suggest that mitochondrial morphology in mature osteoblasts is adapted for extracellular secretion, and secreted mitochondria and MDVs are critical promoters of osteogenesis. Suh, Joonho; Kim, Na-Kyung; Shim, Wonn; Lee, Seung-Hoon; Kim, Hyo-Jeong; Moon, Eunyoung; Sesaki, Hiromi; Jang, Jae Hyuck; Kim, Jung-Eun; Lee, Yun-Sil Seoul Natl Univ, Sch Dent, Dept Mol Genet, Seoul, South Korea; Seoul Natl Univ, Dent Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu, South Korea; Seoul Natl Univ, Sch Dent, Electron Microscopy Res Ctr, Seoul, South Korea; Korea Basic Sci Inst, Electron Microscopy & Spect Team, Cheongju, Chungbuk, South Korea; Johns Hopkins Univ, Dept Cell Biol, Sch Med, Baltimore, MD USA; Korea Basic Sci Inst, Electron Microscopy & Spect Team, Daejeon, South Korea 57210638674; 57210646929; 58090299700; 59056027600; 59615113700; 57210857940; 6603068109; 36792809400; 57209054588; 57226670628 yunlee@snu.ac.kr; CELL METABOLISM CELL METAB 1550-4131 1932-7420 35 2 SCIE CELL BIOLOGY;ENDOCRINOLOGY & METABOLISM 2023 27.7 1.3 13.99 2025-06-25 99 101 BONE; OSTEOBLASTS; EXPRESSION; CELL; FUSION donut mitochondria; FIS1; M1; mitochondria; mitochondrial secretion; mitochondrial transplantation; mitochondrial-derived vesicles; OPA1; osteoblasts; osteogenesis Cell Differentiation; Mitochondria; Mitochondrial Dynamics; Osteoblasts; Osteogenesis; adenosine triphosphate; ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1; animal cell; animal experiment; animal tissue; Article; bone development; bone mass; bone matrix; bone regeneration; cell differentiation; cell maturation; controlled study; female; gene; gene deletion; gene expression regulation; gene knockdown; in vivo study; male; mitochondrial fission 1 gene; mitochondrion; morphology; mouse; nonhuman; optic atrophy 1 gene; ossification; osteoblast; osteoprogenitor cell; promoter region; protein expression; protein secretion; signal transduction; upregulation; metabolism; mitochondrial dynamics; physiology English 2023 2023-02-07 10.1016/j.cmet.2023.01.003 바로가기 바로가기 바로가기 바로가기
Article Risk-informed decision-making and control strategies for autonomous vehicles in emergency situations This paper proposes risk-informed decision-making and control methods for autonomous vehicles (AVs) under severe driving conditions, where many vehicle interactions occur on slippery roads. We assume that the AV should approach a specific safe zone in case of vehicle malfunctioning. In normal situations, the driving behavior of the AV is based on the deterministic finite-state machine (FSM) that makes an appropriate realtime decision depending on the driving condition, which is efficient when compared with some conventional decision-making algorithms; alternatively, in emergency situations, the AV first has to be prevented the rear end conflicts while the specific safe zone is simultaneously determined by evaluating the level of risk via two safety level indicators, i.e., Time-To-Collision (TTC) and Deceleration Rate to Avoid the Crash (DRAC). The safe path that guides the AV to avoid car crashes is generated based on the trajectory optimization theory (i.e., Pontryagin maximum principle), and the AV follows it based on the linear time-varying model predictive control (LTV-MPC), which ensures the AV's lateral stability. We verify the effectiveness of the proposed decision-making and control strategies in various test scenarios, and the results show that the AV behaves appropriately according to the behaviors of surrounding vehicles and road condition. Nguyen, Hung Duy; Choi, Mooryong; Han, Kyoungseok Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Nmotion Co, Incheon 21984, South Korea; TU Wien, Automat & Control Inst ACIN, A-1040 Vienna, Austria Nguyen, Hung/JXL-7245-2024 57225877690; 59885267400; 56465294700 nguyenduyhung@knu.ac.kr;mucho@nmotion.co.kr;kyoungsh@knu.ac.kr; ACCIDENT ANALYSIS AND PREVENTION ACCIDENT ANAL PREV 0001-4575 1879-2057 193 SSCI ERGONOMICS;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH;SOCIAL SCIENCES, INTERDISCIPLINARY;TRANSPORTATION 2023 5.7 1.3 4.27 2025-06-25 18 19 Autonomous vehicle; Collision avoidance; Decision-making; Finite state machine; Model predictive control; Optimal path planning MODEL-PREDICTIVE CONTROL; DYNAMICS CONTROL; ALGORITHM; DESIGN; MPC Autonomous vehicle; Collision avoidance; Decision-making; Finite state machine; Model predictive control; Optimal path planning Accidents; Autonomous vehicles; Decision making; Motion planning; Predictive control systems; Site selection; Autonomous Vehicles; Collisions avoidance; Control strategies; Decision control; Decision-making strategies; Decisions makings; Finite states machine; Model-predictive control; Optimal path planning; Risk-informed decision making; Model predictive control English 2023 2023-12 10.1016/j.aap.2023.107305 바로가기 바로가기 바로가기 바로가기
Article Environmental petroleomics - Application of ultrahigh-resolution mass spectrometry for molecular-level understanding of the fate of spilled oils Molecular-level investigation of crude oil has become an essential part of oil spill research, It facilitates the assessment of oil behavior, fate, impacts, as well as the evaluation of oil spill origins, toxic substances, and the effect of such incidents. Notable oil spill incidents, such as the Deepwater Horizon, have emphasized the need for molecular-level information on spilled oil to evaluate and monitor environmental damage. In this study, the term 'Environmental Petroleomics' is defined. During the weathering of spilled oil, various effects can alter the oil's chemical composition, including evaporation, dispersion, photo-oxidation, and microbial degradation. The major toxic compounds in the spilled oil are aromatic compounds, followed by polar oxygenated aromatic compounds. Although gas chromatography-mass spectrometry (GC-MS) is an effective approach for compositional analysis of crude oil, it falls short in its ability to separate individual compounds in the weathered oil. This is particularly challenging when dealing with weathered oil enriched with polar oxygen- and sulfur-containing compounds that emerge during the weathering process . Ultra-high-resolution mass spectrometry (UHR-MS) has played a key role in the development of Environmental Petroleomics, proving effective in characterizing various polar species. This review explores the application of ultra-high-resolution mass spectrometry for oil spill research. The study concludes that the toxicity of weathered crude oils results from the photo-oxidation of crude oil molecules into highly oxygenated, water-soluble species. Prospective research in environmental petroleomics concerning the analysis of oil spills may direct its attention towards innovating novel methodologies. These could encompass high-resolution imaging of oil spills, time-resolved analysis of spill dynamics, integration of ultra-high-resolution mass spectrometry (UHR-MS) with complementary techniques, and the utilization of UHR-MS for biomarker analysis. Acter, Thamina; Son, Seungwoo; Kim, Donghwi; Yim, Un Hyuk; Barrow, Mark P.; Shi, Quan; Uddin, Nizam; Kim, Sunghwan East West Univ, Dept Math & Phys Sci, A-2 Jahurul Islam Ave, Dhaka 1212, Bangladesh; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Korea Inst Ocean Sci & Technol, Ecol Risk Res Dept, Geoje 53201, South Korea; Univ Warwick, Dept Chem, Coventry CV4 7AL, England; China Univ Petr, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China; Daffodil Int Univ, Dept Nutr & Food Engn, Dhaka 1216, Bangladesh Kim, Sunghwan/HKN-9812-2023; Barrow, Mark/C-3145-2009; Yim, Un Hyuk/HLQ-2591-2023; Uddin, Nizam/N-3536-2014; Uddin, Dr. Nizam/N-3536-2014 56768064900; 57206473214; 58839420600; 6602461626; 7005659596; 35280644500; 57188533756; 57203772967 sunghwank@knu.ac.kr; TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY TRENDS ENVIRON ANAL 2214-1588 40 SCIE CHEMISTRY, ANALYTICAL;ENVIRONMENTAL SCIENCES 2023 11.1 1.4 0.24 2025-06-25 5 6 Environmental monitoring; Environmental pollutants; High resolution mass spectrometry; Molecular markers; Crude oil; Petroleum hydrocarbon degradation ELECTROSPRAY-IONIZATION; NAPHTHENIC ACIDS; CRUDE-OIL; AROMATIC-HYDROCARBONS; INTERFACIAL MATERIAL; ORGANIC-ACIDS; WATER; BIODEGRADATION; TOXICITY; TOXICOKINETICS Crude oil; Environmental monitoring; Environmental pollutants; High resolution mass spectrometry; Molecular markers; Petroleum hydrocarbon degradation English 2023 2023-12 10.1016/j.teac.2023.e00212 바로가기 바로가기 바로가기 바로가기
Article; Proceedings Paper Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke: The OPTIMAL-BP Randomized Clinical Trial Importance Optimal blood pressure (BP) control after successful reperfusion with endovascular thrombectomy (EVT) for patients with acute ischemic stroke is unclear. Objective To determine whether intensive BP management during the first 24 hours after successful reperfusion leads to better clinical outcomes than conventional BP management in patients who underwent EVT. Design, Setting, and Participants Multicenter, randomized, open-label trial with a blinded end-point evaluation, conducted across 19 stroke centers in South Korea from June 2020 to November 2022 (final follow-up, March 8, 2023). It included 306 patients with large vessel occlusion acute ischemic stroke treated with EVT and with a modified Thrombolysis in Cerebral Infarction score of 2b or greater (partial or complete reperfusion). Interventions Participants were randomly assigned to receive intensive BP management (systolic BP target <140 mm Hg; n=155) or conventional management (systolic BP target 140-180 mm Hg; n=150) for 24 hours after enrollment. Main Outcomes and MeasuresThe primary outcome was functional independence at 3 months (modified Rankin Scale score of 0-2). The primary safety outcomes were symptomatic intracerebral hemorrhage within 36 hours and death related to the index stroke within 3 months. Results The trial was terminated early based on the recommendation of the data and safety monitoring board, which noted safety concerns. Among 306 randomized patients, 305 were confirmed eligible and 302 (99.0%) completed the trial (mean age, 73.0 years; 122 women [40.4%]). The intensive management group had a lower proportion achieving functional independence (39.4%) than the conventional management group (54.4%), with a significant risk difference (-15.1% [95% CI, -26.2% to -3.9%]) and adjusted odds ratio (0.56 [95% CI, 0.33-0.96]; P=.03). Rates of symptomatic intracerebral hemorrhage were 9.0% in the intensive group and 8.1% in the conventional group (risk difference, 1.0% [95% CI, -5.3% to 7.3%]; adjusted odds ratio, 1.10 [95% CI, 0.48-2.53]; P=.82). Death related to the index stroke within 3 months occurred in 7.7% of the intensive group and 5.4% of the conventional group (risk difference, 2.3% [95% CI, -3.3% to 7.9%]; adjusted odds ratio, 1.73 [95% CI, 0.61-4.92]; P=.31). Conclusions and Relevance Among patients who achieved successful reperfusion with EVT for acute ischemic stroke with large vessel occlusion, intensive BP management for 24 hours led to a lower likelihood of functional independence at 3 months compared with conventional BP management. These results suggest that intensive BP management should be avoided after successful EVT in acute ischemic stroke. Trial Registration ClinicalTrials.gov Identifier: NCT04205305 Nam, Hyo Suk; Kim, Young Dae; Heo, JoonNyung; Lee, Hyungwoo; Jung, Jae Wook; Choi, Jin Kyo; Lee, Il Hyung; Lim, In Hwan; Hong, Soon-Ho; Baik, Minyoul; Kim, Byung Moon; Kim, Dong Joon; Shin, Na-Young; Cho, Bang-Hoon; Ahn, Seong Hwan; Park, Hyungjong; Sohn, Sung-Il; Hong, Jeong-Ho; Song, Tae-Jin; Chang, Yoonkyung; Kim, Gyu Sik; Seo, Kwon-Duk; Lee, Kijeong; Chang, Jun Young; Seo, Jung Hwa; Lee, Sukyoon; Baek, Jang-Hyun; Cho, Han-Jin; Shin, Dong Hoon; Kim, Jinkwon; Yoo, Joonsang; Lee, Kyung-Yul; Jung, Yo Han; Hwang, Yang-Ha; Kim, Chi Kyung; Kim, Jae Guk; Lee, Chan Joo; Park, Sungha; Lee, Hye Sun; Kwon, Sun U.; Bang, Oh Young; Anderson, Craig S.; Heo, Ji Hoe Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Radiol, Coll Med, Seoul, South Korea; Korea Univ, Dept Neurol, Anam Hosp, Seoul, South Korea; Coll Med, Seoul, South Korea; Chosun Univ, Dept Neurol, Sch Med, Gwangju, South Korea; Keimyung Univ, Brain Res Inst, Dept Neurol, Sch Med, Daegu, South Korea; Ewha Womans Univ, Coll Med, Dept Neurol, Seoul Hosp, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Neurol, Mokdong Hosp, Seoul, South Korea; Ilsan Hosp, Dept Neurol, Natl Hlth Insurance Serv, Goyang, South Korea; Univ Ulsan, Coll Med, Dept Neurol, Asan Med Ctr, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Neurol, Coll Med, Busan, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Neurol, Sch Med, Seoul, South Korea; Pusan Natl Univ, Dept Neurol, Sch Med, Busan, South Korea; Gachon Univ, Dept Neurol, Gil Med Ctr, Incheon, South Korea; Yonsei Univ, Dept Neurol, Severance Hosp, Coll Med, Yongin, South Korea; Yonsei Univ, Dept Neurol, Gangnam Severance Hosp, Coll Med, Yongin, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Korea Univ, Guro Hosp, Dept Neurol, Seoul, South Korea; Eulji Univ, Sch Med, Dept Neurol, Daejeon Eulji Med Ctr, Daejeon, South Korea; Yonsei Univ, Dept Internal Med, Div Cardiol, Severance Hosp,Coll Med, Seoul, South Korea; Yonsei Univ, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, Coll Med, Div Cardiol,Severance Hosp, Seoul, South Korea; Yonsei Univ, Dept Res Affairs, Coll Med, Biostat Collaborat Unit, Seoul, South Korea; Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul, South Korea; Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia ; Park, Hyungjong/AAI-5361-2020; Lee, HS/AAD-6757-2019; Lee, Il-Hyung/E-9712-2011; Kim, Jinkwon/N-1878-2018; Lee, Hye Sun/J-2154-2015; Seo, Jung/N-2344-2017; LEE, HYUN/ABC-6119-2021; Kim, Jinkwon/AAR-6729-2021; Seo, Kwonduk/HLG-9100-2023; Hong, Jeong-Ho/T-8099-2018; Heo, JoonNyung/ABI-5389-2020; Lee, Kyung-Yeol/B-9978-2011; Anderson, Craig/F-9026-2013; kim, deog young/Q-8498-2019; CHIA, YOOK CHIN/B-8379-2010; Kim, Dong/AAH-2257-2021 58719143100; 56153946300; 57219861395; 57209973874; 57217003257; 57215910153; 57394223800; 57214234925; 58312729300; 57197951986; 49861594200; 55508933800; 56363572300; 55171752400; 57200401172; 57199865406; 36479287000; 55931654800; 55507164200; 56525550900; 58431244000; 57219304565; 58995258200; 56346807100; 55471870500; 57217310224; 56066538700; 57211361916; 57222389564; 37090736900; 55261162200; 57306378900; 57217582769; 7402311308; 56701057800; 56720623400; 56812485300; 8556278400; 57208650357; 7402624264; 7006620221; 14824521200; 34869576000 hsnam@yuhs.ac; JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION JAMA-J AM MED ASSOC 0098-7484 1538-3598 330 9 SCIE MEDICINE, GENERAL & INTERNAL 2023 63.5 1.4 20.69 2025-06-25 95 92 INDIVIDUAL PATIENT DATA; IMPORTANT DIFFERENCE; BRAIN EDEMA; THERAPY; ASSOCIATION; GUIDELINES; MANAGEMENT; OUTCOMES; SCORE Aged; Blood Pressure; Cerebral Hemorrhage; Female; Humans; Ischemic Stroke; Stroke; Thrombectomy; infusion fluid; inotropic agent; nicardipine; tissue plasminogen activator; acute ischemic stroke; adult; aged; attributable risk; blood pressure monitoring; blood pressure regulation; blood vessel occlusion; brain hemorrhage; clinical evaluation; clinical outcome; computer assisted tomography; Conference Paper; confidence interval; controlled study; crossover procedure; early intervention; female; follow up; Functional Independence Measure; human; hypertension; hypotension; major clinical study; male; modified thrombolysis in cerebral infarction scale; mortality rate; multicenter study; nuclear magnetic resonance imaging; odds ratio; patient safety; percutaneous thrombectomy; randomized controlled trial; Rankin scale; reperfusion; South Korea; systolic blood pressure; blood pressure; brain hemorrhage; cerebrovascular accident; clinical trial; ischemic stroke; thrombectomy English 2023 2023-09-05 10.1001/jama.2023.14590 바로가기 바로가기 바로가기 바로가기
Article On Multi-Robot Data Collection and Offloading for Space-Aerial-Surface Computing This article introduces a novel computing architecture, called space-aerial-surface computing (SASC), for intelligent data collection and offloading via multiple collaborative robots in massive Internet of Things (IoT) sensor networks. The effectiveness of the proposed architecture is justified, and a number of key issues relevant to the proposed architecture are discussed, including data-similarity-aware node selection and clustering, collaborative trajectory planning strategies, the collaboration of heterogeneous robots, and aerial computing-integrated data offloading schemes. Mei, Haoran; Peng, Limei Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea Mei, Haoran/HKF-6510-2023 57208655106; 7201574271 IEEE WIRELESS COMMUNICATIONS IEEE WIREL COMMUN 1536-1284 1558-0687 30 2 SCIE COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS 2023 10.9 1.4 0.35 2025-06-25 3 3 Trajectory planning; 5G mobile communication; Collaboration; Computer architecture; Data collection; Robot sensing systems; Internet of Things AIR Antennas; Collaborative robots; Computer architecture; Data acquisition; Intelligent robots; Internet of things; Network architecture; Sensor networks; Collaborative robots; Computing architecture; Data collection; Data-similarity; Intelligent data; Key Issues; Multirobots; Proposed architectures; Sensors network; Surface computing; Robot programming English 2023 2023-04 10.1109/mwc.005.2200400 바로가기 바로가기 바로가기 바로가기
Meeting Abstract A Single-Arm, Open-Label, Multicenter Study to Assess Molecular Response of P1101 Therapy in Patients with Polycythemia Vera and Elevated Hematocrit: Results from 12-Month Core Study Lee, Sung-Eun; Yoon, Sung-Soo; Yang, Deok-Hwan; Lee, Gyeong Won; Yoon, Seug Yun; Sohn, Sang Kyun; Shin, Ho-Jin; Bae, Sung Hwa; Choi, Chul Won; Choi, Eun-Ji; Cheong, June-Won; Bang, Soo-Mee; Park, Joon Seong; Oh, Sukjoong; Park, Yong; Park, Young Hoon Catholic Univ Korea, Leukemia Res Inst, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Hwasun Hosp, Dept Internal Med, Gwangju, Jeollanam Do, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Coll Med, Dept Internal Med, Jinju, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol, Daegu, South Korea; Pusan Natl Univ Hosp, Busan, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Med Ctr, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Ajou Univ, Sch Med, Dept Hematol Oncol, Suwon, South Korea; Hanyang Univ, Med Ctr, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Mokdong Hosp, Seoul, South Korea Park, Jung Hoon/CZZ-0090-2022; Hyun-Jung, Kim/E-8074-2011; Lee, SangHun/GPW-6306-2022 BLOOD BLOOD 0006-4971 1528-0020 142 SCIE HEMATOLOGY 2023 21.1 1.5 3 English 2023 2023-11-02 10.1182/blood-2023-184431 바로가기 바로가기 바로가기
페이지 이동: