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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Improving the thermoelectric performance of Ti-doped NbFeSb by substitutional doping of the Sb atoms with the isoelectric and heavy Bi atoms | The inherently low figure of merit (ZT) is the main impediment to the commercialization of half-Heusler thermoelectric materials in energy applications. Herein, we demonstrate the effectiveness of substituting Bi on the Sb site in the promising Nb0.8Ti0.2FeSb half-Heusler thermoelectric material to achieve much needed incremental performance improvement. P-Type Nb0.80Ti0.20FeSb1-xBix (x = 0-0.07) samples are prepared by arc melting, hot pressing and annealing. After microstructural analysis, a solubility limit of similar to 2.4%Bi is determined on the Sb site. It is found that the dissolved Bi atoms not only cause significant phonon scattering, leading to a 12% decrease in thermal conductivity, but also increase the density of states effective mass, leading to an increase in the Seebeck coefficient and thus a 21% increase in the power factor in the sample x = 0.03 compared to the sample x = 0.00 at 973 K. Above the Bi-solubility limit, concomitant Sb vacancies are considered and shown to donate holes that strongly decrease the Seebeck coefficient and disproportionately increase the electronic thermal conductivity, leading to worse thermoelectric performance in samples x >= 0.05. Consequently, the effectiveness of this strategy is realized in sample x = 0.03, where the synergistic benefit of suppressed thermal conductivity and increased power factor yields the best ZT of similar to 1.2 at 973 K, which is similar to 36% higher than that of sample x = 0.00. Moreover, the microstrains introduced by Bi-doping lead to increased microhardness, which is desirable for improving the machinability of parts and increasing wear resistance in application. | Kahiu, Joseph Ngugi; Kihoi, Samuel Kimani; Lee, Ho Seong | Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea | Kihoi, Samuel Kimani/IUM-8515-2023 | 57222096169; 57208396874; 55706810400 | hs.lee@knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 9 | 36 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 8.067 | 14.6 | 1.03 | 2025-07-30 | 22 | 23 | LOW THERMAL-CONDUCTIVITY; BOUNDARY-SCATTERING; POWER-FACTOR; ENHANCEMENT; MOBILITY; SYSTEM | Atoms; Electric power factor; Iron; Iron compounds; Niobium compounds; Seebeck coefficient; Solubility; Thermal conductivity; Thermoelectric equipment; Titanium compounds; Wear resistance; Commercialisation; Energy applications; Half-heusler; Isoelectric; Power factors; Solubility limits; Thermo-Electric materials; Thermoelectric material; Thermoelectric performance; Ti doped; Hot pressing | English | 2021 | 2021-09-28 | 10.1039/d1tc02896k | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Quantitative Precipitation Estimates Using Machine Learning Approaches with Operational Dual-Polarization Radar Data | Traditional radar-based rainfall estimation is typically done by known functional relationships between the rainfall intensity (R) and radar measurables, such as R-Z(h), R-(Z(h), Z(DR)), etc. One of the biggest advantages of machine learning algorithms is the applicability to a non-linear relationship between a dependent variable and independent variables without any predefined relationships. We explored the potential use of two supervised machine learning methods (regression tree and random forest) in rainfall estimation using dual-polarization radar variables. The regression tree does not require normalization and scaling of data; however, this method is quite unstable since each split depends on the parent split. Since the random forest is an ensemble method of regression trees, it has less variability in prediction compared with regression trees, but consumes more computer resources. We considered several different configurations for machine learning algorithms with different sets of dependent and independent variables. The random forest model was appropriately tuned. In the test of variable importance, the specific differential phase (differential reflectivity) was the most important variable to predict the rainfall rate (residual that is the difference between the true rainfall rate and the one estimated from the R-Z relationship). The models were evaluated by 10-fold cross-validation. The best model was the random forest model using a residual with the non-classified training set. The results indicated that the machine learning algorithms outperformed the traditional R-Z relationship. Then, we applied the best machine learning model to an S-band dual-polarization radar (Mt. Myeonbong) and validated the result with ground rain gauges. The results of the application to radar data showed that the estimates of the residuals had spatial variability. The stratiform and weak rain areas had positive residuals while convective areas had negative residuals, indicating that the spatial error structure driven by the R-Z relationship was well captured by the model. The rainfall rates of all pixels over the study area were adjusted with the estimated residuals. The rainfall rates adjusted by residual showed excellent agreement with the rain gauge, especially at high rainfall rates. | Shin, Kyuhee; Song, Joon Jin; Bang, Wonbae; Lee, GyuWon | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Ctr Atmospher REmote Sensing CARE, Daegu 41566, South Korea; Baylor Univ, Dept Stat Sci, Waco, TX 76798 USA | ; Shin, Kyuhee/LMO-2829-2024 | 57222003871; 14062434200; 57190066856; 7404852271 | kyuhee@knu.ac.kr;Joon_Song@baylor.edu;wonbaebang@knu.ac.kr;gyuwon@knu.ac.kr; | REMOTE SENSING | REMOTE SENS-BASEL | 2072-4292 | 13 | 4 | SCIE | ENVIRONMENTAL SCIENCES;GEOSCIENCES, MULTIDISCIPLINARY;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2021 | 5.349 | 14.6 | 2.07 | 2025-07-30 | 20 | 28 | machine learning; rainfall estimation; polarimetric radar; R– Z relationship | DROP SIZE DISTRIBUTIONS; RAINFALL ESTIMATION; POLARIMETRIC RADAR; BAND RADAR; VARIABILITY; DISDROMETER; ERRORS; GAUGE | Machine learning; Polarimetric radar; R-Z relationship; Rainfall estimation | Decision trees; Forestry; Polarization; Radar; Rain; Rain gages; Random forests; Supervised learning; 10-fold cross-validation; Differential reflectivity; Dual polarization radars; Machine learning approaches; Machine learning models; Non-linear relationships; Specific differential phase; Supervised machine learning; Learning systems | English | 2021 | 2021-02 | 10.3390/rs13040694 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Revision of WDM7 Microphysics Scheme and Evaluation for Precipitating Convection over the Korean Peninsula | The Weather Research and Forecasting (WRF) Double-Moment 7-Class (WDM7) cloud microphysics scheme was developed to parameterize cloud and precipitation processes explicitly for mesoscale phenomena in the Korean Integrated Model system. However, the WDM7 scheme has not been evaluated for any precipitating convection system over the Korean peninsula. This study modified WDM7 and evaluated simulated convection during summer and winter. The suggested modifications included the integration of the new fall velocity-diameter relationship of raindrops and mass-weighted terminal velocity of solid-phase precipitable hydrometeors (the latter is for representing mixed-phase particles). The mass-weighted terminal velocity for snow and graupel has been suggested by Dudhia et al. (2008) to allow for a more realistic representation of partially rimed particles. The WDM7 scheme having an additional hail category does not apply this terminal velocity only for hail. Additionally, the impact of enhanced collision-coalescence (C-C) efficiency was investigated. An experiment with enhanced C-C efficiency overall improved the precipitation skill scores, such as probability of detection, equitable threat score, and spatial pattern correlation, compared with those of the control experiment for the summer and winter cases. With application of the new mass-weighted terminal velocity of solid-phase hydrometeors, the hail mixing ratio at the surface was considerably reduced, and rain shafts slowed down low-level winds for the winter convective system. Consequently, the simulated hydrometeors were consistent with observations retrieved via remote sensing. The fall velocity-diameter relationship of raindrops further reduced the cloud ice amount. The proposed modifications in our study improved the simulated precipitation and hydrometeor profiles, especially for the selected winter convection case. | Jang, Sungbin; Lim, Kyo-Sun Sunny; Ko, Jeongsu; Kim, Kwonil; Lee, GyuWon; Cho, Su-Jeong; Ahn, Kwang-Deuk; Lee, Yong-Hee | Kyungpook Natl Univ, Ctr Atmospher Remote Sensing CARE, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Korea Meteorol Adm, Numer Modeling Ctr, Numer Data Applicat Div, Seoul 07062, South Korea | Lim, Kyo-Sun/I-3811-2012; Kim, Kwonil/HTN-0103-2023 | 57282609900; 57211926026; 57282452500; 57191964318; 7404852271; 57283076200; 57189992426; 47962282400 | jsb2718@knu.ac.kr;kyosunlim@knu.ac.kr;wjdtnxx@naver.com;kwonil@knu.ac.kr;gyuwon@knu.ac.kr;qhtjr3721@korea.kr;stratus12@korea.kr;gonos2004@korea.kr; | REMOTE SENSING | REMOTE SENS-BASEL | 2072-4292 | 13 | 19 | SCIE | ENVIRONMENTAL SCIENCES;GEOSCIENCES, MULTIDISCIPLINARY;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2021 | 5.349 | 14.6 | 0.64 | 2025-07-30 | 8 | 8 | WDM7; collision-coalescence efficiency; mass-weighted terminal velocity; fall velocity; hydrometeor type | OPTICAL DISDROMETER; TERMINAL VELOCITY; CLOUD; PARAMETERIZATION; CLASSIFICATION; IMPROVEMENTS; SIMULATIONS; IMPACTS; WEATHER; SYSTEM | Collision-coalescence efficiency; Fall velocity; Hydrometeor type; Mass-weighted terminal velocity; WDM7 | Clouds; Coalescence; Drops; Precipitation (meteorology); Remote sensing; Velocity; Weather forecasting; (WRF) double-moment 7-class; Collision-coalescence efficiency; Fall velocities; Hydrometeor type; Mass-weighted terminal velocity; Microphysics; Solid phasis; Solid-phase; Terminal velocity; Weather research and forecasting; Efficiency | English | 2021 | 2021-10 | 10.3390/rs13193860 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Vertical Structure of Ice Clouds and Vertical Air Motion from Vertically Pointing Cloud Radar Measurements | The vertical structure of ice clouds and vertical air motion (V-air) were investigated using vertically pointing Ka-band cloud radar. The distributions of reflectivity (Z), Doppler velocity (V-D), and spectrum width (SW) were analyzed for three ice cloud types, namely, cirrus, anvil, and stratiform clouds. The radar parameters of the cirrus clouds showed narrower distributions than those of the stratiform and anvil clouds. In the vertical structures, the rapid growth of Z and V-D occurred in the layer between 8 and 12 km (roughly a layer of -40 & DEG;C to -20 & DEG;C) for all ice clouds. The prominent feature in the stratiform clouds was an elongated "S " shape in the V-D near 7-7.5 km (at approximately -16 & DEG;C to -13 & DEG;C) due to a significant decrease in an absolute value of V-D. The mean terminal fall velocity (V-t) and V-air in the ice clouds were estimated using pre-determined V-t-Z relationships (V-t = aZ(b)) and the observed V-D. Although the cirrus clouds demonstrated wide distributions in coefficients a and exponents b depending on cloud heights, they showed a smaller change in Z and V-t values compared to that of the other cloud types. The anvil clouds had a larger exponent than that of the stratiform clouds, indicating that the ice particle density of anvil clouds increases at a faster rate compared with the density of stratiform clouds for the same Z increment. The significant positive V-air appeared at the top of all ice clouds in range up to 0.5 m s(-1), and the anvil clouds showed the deepest layer of upward motion. The stratiform and anvil clouds showed a dramatic increase in vertical air motion in the layer of 6-8 km as shown by the rapid decrease of V-D. This likely caused increase of supersaturation above. A periodic positive V-air linked with a significant reduction in V-D appeared at the height of 7-8 km (approximately -15 & DEG;C) dominantly in the stratiform clouds. This layer exhibited a bi-modal power spectrum produced by pre-existing larger ice particles and newly formed numerous smaller ice particles. This result raised a question on the origins of smaller ice particles such as new nucleation due to increased supersaturation by upward motion below or the seeder-feeder effect. In addition, the retrieved V-air with high-resolution data well represented a Kelvin-Helmholtz wave development. | Ye, Bo-Young; Lee, GyuWon | Pusan Natl Univ, Inst Environm Studies, Busan 46241, South Korea; Kyungpook Natl Univ, Ctr Atmospher Remote Sensing CARE, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | 56727476700; 7404852271 | boyoungye@pusan.ac.kr;gyuwon@knu.ac.kr; | REMOTE SENSING | REMOTE SENS-BASEL | 2072-4292 | 13 | 21 | SCIE | ENVIRONMENTAL SCIENCES;GEOSCIENCES, MULTIDISCIPLINARY;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2021 | 5.349 | 14.6 | 0.24 | 2025-07-30 | 5 | 5 | ice clouds; vertical structure; vertical air motion; terminal velocity; cloud radar; V-t-Z relationship; bi-modal power spectrum | DOPPLER RADAR; CIRRUS CLOUDS; PART I; MICROPHYSICS SCHEME; WATER-CONTENT; CLIMATOLOGY; LIDAR; SIZE | Cloud radar; Ice clouds; Terminal velocity; V<sub>t</sub> –Z relationship, bi-modal power spectrum; Vertical air motion; Vertical structure | Air; Clouds; Ice; Radar; Radar measurement; Velocity; Air motion; Cloud radar; Ice clouds; Ice particles; Power-spectra; Stratiform clouds; Terminal velocity; Velocity –Z relationship, bi-modal power spectrum; Vertical air motion; Vertical structures; Power spectrum | English | 2021 | 2021-11 | 10.3390/rs13214349 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress | Background: Cisplatin (cis-diamminedichloroplatinum II) is widely used for the treatment of cancer, but its cellular toxicity, especially in the form of oxidative stress, limits its use in multiple organs including the lungs. As a cellular organelle, cilia play an important role in cellular function and can be damaged by oxidative stress. However, the effect of cisplatin-induced lung toxicity on cilia has not yet been defined. Herein, we investigated the association of cilia and oxidative stress with cisplatin-induced lung damage. Methods: Mice were administered with cisplatin. Some mice were treated with 2-(2,2,6,6-Tetramethylpiperidin-1oxyl-4-ylamino)-2-oxoethyl) triphenylphosphonium chloride (Mito-TEMPO, a mitochondria-specific antioxidant) before the administration of cisplatin. Disruption of cilia was evaluated by the detection of ciliary proteins and fragments in the bronchoalveolar lavage fluid (BALF). Results: Cisplatin caused the thickening of interalveolar septa, infiltration of immune cells into the interalveolar septa, and increased protein concentration and total cell number in the BALF. Cisplatin also increased ciliary fragments and proteins in the BALF. In the lungs, cisplatin increased the production of hydrogen peroxide, lipid peroxidation, and apoptosis, while decreasing manganese superoxide dismutase, isocitrate dehydrogenase 2, and catalase expression. Treatment with Mito-TEMPO prevented cisplatin-induced lung damage, ciliary fragmentation, oxidative stress, and apoptosis. Conclusion: By increasing oxidative stress in the lung, cisplatin induces lung cell damage, disruption of cilia, and release of disrupted cilia into the BALF. This suggests that cisplatin-induced lung damage can damage the cilia, manifesting as increased ciliary proteins in the BALF. | Han, Yong Kwon; Kim, Ji Su; Jang, GiBong; Park, Kwon Moo | Kyungpook Natl Univ, Sch Med, Dept Anat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57226292650; 57226288568; 57260433300; 8785448200 | kmpark@knu.ac.kr; | FREE RADICAL BIOLOGY AND MEDICINE | FREE RADICAL BIO MED | 0891-5849 | 1873-4596 | 177 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENDOCRINOLOGY & METABOLISM | 2021 | 8.101 | 14.7 | 1.9 | 2025-07-30 | 26 | 27 | Cisplatin; Lung damage; Cilia; Oxidative stress; Apoptosis | INDUCED NEPHROTOXICITY; MOLECULAR-MECHANISMS; CANCER-CHEMOTHERAPY; INDUCED TOXICITY; MITOCHONDRIAL; INJURY; SUPPLEMENTATION; DYSFUNCTION; APOPTOSIS | Apoptosis; Cilia; Cisplatin; Lung damage; Oxidative stress | Animals; Antioxidants; Cilia; Cisplatin; Lung; Mice; Oxidative Stress; alpha tubulin; Arl13B protein; catalase; cell protein; cisplatin; hydrogen peroxide; isocitrate dehydrogenase 2; manganese superoxide dismutase; protein Bax; protein bcl xl; unclassified drug; antioxidant; cisplatin; animal experiment; animal model; apoptosis; Article; bronchoalveolar lavage fluid; cell count; cell disruption; cell infiltration; cilium; controlled study; disease association; drug safety; immunocompetent cell; lipid peroxidation; lung alveolus cell; lung injury; male; mouse; nonhuman; oxidation reduction state; oxidative stress; pathogenesis; protein expression level; protein secretion; animal; lung; metabolism; oxidative stress | English | 2021 | 2021-12 | 10.1016/j.freeradbiomed.2021.10.032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of computer literacy on the working time of the dental CAD software program | Purpose: The purpose of this study was to compare the correlation between the teaming effect of dental computer-aided design (CAD) software and computer literacy in the clinical and preclinical experience groups of computer-aided design and computer-aided manufacturing (CAD/CAM). Methods: A total of 28 participants were recruited, including 14 dental students and 14 dental technicians. Their working time was evaluated using a custom abutment design with two dental CAD software program (exocad Chntill and Deltanine). The working time of custom abutment design was measured 3 times. A survey was conducted to evaluate the computer literacy. For statistical analysis. Mann-Whitney U test was used to analyze the difference between the clinical and preclinical experience groups and the correlation between computer literacy and reduction in working time was confirmed by Spearman's Rank correlation analysis (alpha=.05). Results: The median working time showed the clinical experience group had faster than the preclinical experience group (P<.001). On the other hand, the reduction in working time was higher in the preclinical experience group (P=.002). Only preclinical experience group had a significant positive correlation between the computer literacy and reduction in working time (P<.001). Conclusions: Basic computer skills are required for first-time users to achieve an excellent learning effect of dental CAD software program. | Son, KeunBaDa; Lee, Kyu-Bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea | SON, Keunbada/AAG-8089-2019; Son, Keunbada/AAG-8089-2019 | 57202916520; 15925571200 | kblee@knu.ac.kr; | JOURNAL OF PROSTHODONTIC RESEARCH | J PROSTHODONT RES | 1883-1958 | 2212-4632 | 65 | 2 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 4.338 | 14.7 | 1.12 | 2025-07-30 | 5 | 5 | Dental CAD/CAM; Dental CAD software; Learning effect; Computer literacy | Computer literacy; Dental CAD software; Dental CAD/CAM; Learning effect | Computer Literacy; Computer-Aided Design; Dental Prosthesis Design; Humans; Software; adult; article; clinical article; computer aided design/computer aided manufacturing; computer literacy; correlation analysis; dental student; dental technician; female; human; human experiment; learning; male; preclinical study; rank sum test; skill; software; working time; computer aided design; human computer interaction; prosthesis design; software | English | 2021 | 2021 | 10.2186/jpr.jpr_d_20_00030 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Macrophage peroxiredoxin 5 deficiency promotes lung cancer progression via ROS-dependent M2-like polarization | Strategies for cancer treatment have traditionally focused on suppressing cancer cell behavior, but many recent studies have demonstrated that regulating the tumor microenvironment (TME) can also inhibit disease progression. Macrophages are major TME components, and the direction of phenotype polarization is known to regulate tumor behavior, with M2-like polarization promoting progression. It is also known that reactive oxygen species (ROS) in macrophages drive M2 polarization, and M2 polarization promote lung cancer progression. Lung cancer patients with lower expression of the antioxidant enzyme peroxiredoxin 5 (Prx5) demonstrate poorer survival. This study revealed that Prx5 deficiency in macrophages induced M2 macrophage polarization by lung cancer. We report that injection of lung cancer cells produced larger tumors in Prx5-deficit mice than wild-type mice independent of cancer cell Prx5 expression. Through co-culture with lung cancer cell lines, Prx5deficient macrophages exhibited M2 polarization, and reduced expression levels of the M1-associated inflammatory factors iNOS, TNF alpha, and Il-1 beta. Moreover, these Prx5-deficient macrophages promoted the proliferation and migration of co-cultured lung cancer cells. Conversely, suppression of ROS generation by N-acetyl cysteine (NAC) inhibited the M2-like polarization of Prx5-deficient macrophages, increased expression levels of inflammatory factors, inhibited the proliferation and migration of co-cultured lung cancer cells, and suppressed tumor growth in mice. These findings suggest that blocking the M2 polarization of macrophages may promote lung cancer regression. | Seong, Jung Bae; Kim, Bokyung; Kim, Soyoon; Kim, Mi Hye; Park, Young-Ho; Lee, Youngjeon; Lee, Hong Jun; Hong, Chang-Won; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr, Cheongju, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr FARRC, Cheongju, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju, Chungbuk, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju, Chungbuk, South Korea; Res Inst eBiogen Inc, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | Hong, Chang-Won/L-1272-2015; Lee, Youngjeon/LZH-8969-2025; lee, wj/JNR-4926-2023 | 57202134219; 57205869587; 57292105000; 57193994930; 56246852400; 57199022088; 35215736300; 55567018400; 57210068061 | lee1@knu.ac.kr; | FREE RADICAL BIOLOGY AND MEDICINE | FREE RADICAL BIO MED | 0891-5849 | 1873-4596 | 176 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENDOCRINOLOGY & METABOLISM | 2021 | 8.101 | 14.7 | 1.58 | 2025-07-30 | 29 | 27 | Peroxiredoxin 5; Lung cancer; Tumor microenvironment; Macrophage polarization; ROS | EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-ASSOCIATED MACROPHAGES; OXIDATIVE STRESS; EXPRESSION; MICROENVIRONMENT; ANGIOGENESIS; ACTIVATION; MARKER; CELLS; SOX2 | Lung cancer; Macrophage polarization; Peroxiredoxin 5; ROS; Tumor microenvironment | Animals; Cell Line, Tumor; Humans; Lung Neoplasms; Macrophage Activation; Macrophages; Mice; Peroxiredoxins; Reactive Oxygen Species; Tumor Microenvironment; acetylcysteine; inducible nitric oxide synthase; interleukin 1beta; peroxiredoxin 5; reactive oxygen metabolite; tumor necrosis factor; peroxiredoxin; reactive oxygen metabolite; animal cell; animal experiment; animal model; antineoplastic activity; Article; cancer cell culture; cancer growth; cancer inhibition; cancer regression; carcinogenesis; cell migration; cell proliferation; controlled study; down regulation; gene expression regulation; human; human cell; lung cancer; lung cancer cell line; macrophage; macrophage polarization; male; mouse; nonhuman; peroxiredoxin 5 deficiency; phenotype; polarization; protein deficiency; tumor promotion; wild type; animal; genetics; lung tumor; macrophage activation; tumor cell line; tumor microenvironment | English | 2021 | 2021-11-20 | 10.1016/j.freeradbiomed.2021.10.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Study on the incremental sheet forming of CFRP sheet | Due to the increasing demand, carbon fiber reinforced plastics (CFRP) have become more and more important in many fields. In this study, a hybrid incremental sheet-forming technique for carbon fiber reinforced thermosets (CFRTS) was developed and applied. In this technique, a layer of CFRP sheet was placed under another layer of mild steel sheet called the dummy sheet. Various experiments were conducted, and the results show that this forming strategy can be applied to CFRP sheets having single-or multi-layer prepregs. In addition, the mesoscale model simulation using ABAQUS/Explicit was performed for the incremental sheet forming (ISF) process of the CFRP sheet, and the effect of orientation of fiber on the forming process was discussed. The FE simulation results for the ISF of the CFRP sheet was able to predict the deformation shape and shear angle of the CFRP sheet accurately compared to the experiment. | Xiao, Xiao; Kim, Jin-Jae; Oh, Seok-Hwan; Kim, Young-Suk | Kyungpook Natl Univ, Grad Sch, Daegu 41566, South Korea; LG Display Co, Paju 10845, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Oh, Seokhwan/MXJ-9041-2025; Kim, Sang-Hoon/AAA-2248-2020 | 57195394085; 57209555877; 57188660863; 36065820800 | caekim@knu.ac.kr; | COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING | COMPOS PART A-APPL S | 1359-835X | 1878-5840 | 141 | SCIE | ENGINEERING, MANUFACTURING;MATERIALS SCIENCE, COMPOSITES | 2021 | 9.463 | 14.7 | 1.16 | 2025-07-30 | 19 | 20 | Carbon fiber reinforced plastic; Incremental sheet forming; Finite element method; Mesoscale | SHELL FINITE-ELEMENT; MECHANICAL-BEHAVIOR; BIAS-EXTENSION; COMPOSITE; DEFORMATION; SIMULATION; MODEL; MESO | Carbon fiber reinforced plastic; Finite element method; Incremental sheet forming; Mesoscale | Graphite fibers; Abaqus/explicit; Carbon fiber reinforced; Carbon fiber reinforced plastics (CFRP); CFRP sheet; FE-simulation; Incremental sheet forming; Mesoscale model simulation; Shear angles; Carbon fiber reinforced plastics | English | 2021 | 2021-02 | 10.1016/j.compositesa.2020.106209 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-σ protein | Proline rich Akt substrate (PRAS40) is a component of mammalian target of rapamycin complex 1 (mTORC1) and activated mTORC1 plays important roles for cellular survival in response to oxidative stress. However, the roles of PRAS40 in dopaminergic neuronal cell death have not yet been examined. Here, we examined the roles of Tat-PRAS40 in MPP+- and MPTP-induced dopaminergic neuronal cell death. Our results showed that Tat-PRAS40 effectively transduced into SH-SY5Y cells and inhibited DNA damage, ROS generation, and apoptotic signaling in MPP+-induced SH-SY5Y cells. Further, these protective mechanisms of Tat-PRAS40 protein display through phosphorylation of Tat-PRAS40, Akt and direct interaction with 14-3-3 sigma protein, but not via the mTOR-dependent signaling pathway. In a Parkinson's disease animal model, Tat-PRAS40 transduced into dopaminergic neurons in mouse brain and significantly protected against dopaminergic cell death by phosphorylation of Tat-PRAS40, Akt and interaction with 14-3-3 sigma protein. In this study, we demonstrated for the first time that Tat-PRAS40 directly protects against dopaminergic neuronal cell death. These results indicate that Tat-PRAS40 may provide a useful therapeutic agent against oxidative stress-induced dopaminergic neuronal cell death, which causes diseases such as PD. | Eum, Won Sik; Kim, Dae Won; Yeo, Eun Ji; Yeo, Hyeon Ji; Choi, Yeon Joo; Cha, Hyun Ju; Park, Jinseu; Han, Kyu Hyung; Kim, Duk-Soo; Yu, Yeon Hee; Cho, Sung-Woo; Kwon, Oh-Shin; Cho, Yong-Jun; Shin, Min Jea; Choi, Soo Young | Hallym Univ, Dept Biomed Sci, Chunchon 24252, South Korea; Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 24252, South Korea; Kangneung Wonju Natl Univ, Coll Dent, Res Inst Oral Sci, Dept Biochem & Mol Biol, Kangnung 25457, South Korea; Soonchunhyang Univ, Coll Med, Dept Anat, Cheonan 31538, South Korea; Soonchunhyang Univ, Coll Med, BK21 FOUR Project, Cheonan 31538, South Korea; Univ Ulsan, Dept Biochem & Mol Biol, Seoul 05505, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Taegu 41566, South Korea; Hallym Univ, Med Ctr, Dept Neurosurg, Chunchon 24253, South Korea | Choi, Yeon/S-7189-2019; YU, YEONHEE/IQR-5952-2023 | 6602752494; 56194913400; 56406995100; 55894879100; 56406707500; 56428537100; 35277816700; 7402963265; 23089792500; 56427192400; 57190428583; 7402195859; 55277889800; 35485651200; 56912545700 | wehome3@hallym.ac.kr;sychoi@hallym.ac.kr; | FREE RADICAL BIOLOGY AND MEDICINE | FREE RADICAL BIO MED | 0891-5849 | 1873-4596 | 172 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENDOCRINOLOGY & METABOLISM | 2021 | 8.101 | 14.7 | 0.79 | 2025-07-30 | 8 | 11 | Tat-PRAS40; Dopaminergic neurons; Oxidative stress; Parkinson's disease; Protein therapy | RICH AKT SUBSTRATE; PARKINSONS-DISEASE; MAMMALIAN TARGET; TUBEROUS SCLEROSIS; OXIDATIVE STRESS; FREE-RADICALS; MTOR; PRAS40; STROKE; BRAIN | Dopaminergic neurons; Oxidative stress; Parkinson's disease; Protein therapy; Tat-PRAS40 | Animals; Apoptosis; Cell Death; Dopaminergic Neurons; Mice; Oxidative Stress; Reactive Oxygen Species; 1 methyl 4 phenylpyridinium; 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine; antiparkinson agent; mammalian target of rapamycin; protein kinase B; reactive oxygen metabolite; stratifin; Tat proline rich Akt substrate 40; Tat protein; unclassified drug; reactive oxygen metabolite; animal experiment; animal model; animal tissue; Article; concentration (parameter); controlled study; DNA damage; dopaminergic nerve cell; drug inhibition; genetic transduction; human; human cell; male; mouse; MPP+-induced neurotoxicity; MPTP-induced parkinsonism; mTOR signaling; neuroapoptosis; neuroprotection; nonhuman; oxidative stress; Parkinson disease; protein function; protein phosphorylation; protein protein interaction; SH-SY5Y cell line; animal; apoptosis; cell death; oxidative stress | English | 2021 | 2021-08-20 | 10.1016/j.freeradbiomed.2021.06.026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical course of COVID-19 patients treated with ECMO: A multicenter study in Daegu, South Korea | Background: The COVID-19 pandemic has caused an epidemic of critical patients, some of whom have been treated with extracorporeal membrane oxygenation (ECMO). This purpose of study is to describe the clinical course of COVID-19 patients treated with ECMO. Methods: A multicentered study of critical patients with COVID-19 treated at six hospitals in Daegu was conducted between January and April 2020. Results: Among the 80 patients receiving mechanical ventilation support, 19 (24%) were treated with ECMO included (median age 63.0 years). Eight of the 19 patients (42%) were weaned off ECMO (9.8 days, IQR 7.0-13.7). Among them, four patients were also weaned off mechanical ventilation (33.4 days, IQR 29.3 - 35.7), three were still receiving mechanical ventilation (50.9 days), and one expired after ECMO weaning. According to the univariate analysis, the factor that was associated with successful ECMO weaning was vitamin B12 treatment (p = 0.028). Conclusions: During the COVID-19 epidemic, ECMO weaning and mortality rates were 42% and 58%, respectively. (C) 2020 Elsevier Inc. All rights reserved. | Jang, Woo Sung; Kim, JaeBum; Baek, Jonghyun; Jung, Hanna; Jang, Jae Seok; Park, Jae Seok; Oh, Tak-Hyuk; Jang, Se Yong; Kim, Yun Seok; Kwon, Yong Shik | Keimyung Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Dongsan Hosp, Daegu, South Korea; Keimyung Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Daegu Dongsan Hosp, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Med Ctr, Daegu, South Korea; Kyungpook Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Kyungpook Natl Univ Hosp, Daegu, South Korea; Daegu Catholic Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Med Ctr, Daegu, South Korea; Keimyung Univ, Coll Med, Dept Internal Med, Div Pulmonol,Daegu Dongsan Hosp, Daegu, South Korea; Kyungpook Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Chilgok Hosp, Daegu, South Korea; Keimyung Univ, Coll Med, Dept Internal Med, Div Pulmonol,Dongsan Hosp, Daegu, South Korea | Kim, Hyung Joon/ABD-3143-2020; Jung, Hanna/Y-4165-2019 | 36948706600; 59678969500; 57204158298; 56467570700; 55561415300; 8866846500; 56467700700; 57207977889; 24338526600; 57203804743 | whiteuri09@gmail.com; | HEART & LUNG | HEART LUNG | 0147-9563 | 1527-3288 | 50 | 1 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;NURSING;RESPIRATORY SYSTEM | 2021 | 3.149 | 14.8 | 0.88 | 2025-07-30 | 8 | 11 | COVID-19; ECMO; ARDS | EXTRACORPOREAL MEMBRANE-OXYGENATION; LUNG INJURY; MORTALITY; SEPSIS | ARDS; COVID-19; ECMO | COVID-19; Extracorporeal Membrane Oxygenation; Humans; Middle Aged; Pandemics; Respiration, Artificial; SARS-CoV-2; angiotensin receptor antagonist; antibiotic agent; antivirus agent; ascorbic acid; cobicistat plus darunavir; cyanocobalamin; dipeptidyl carboxypeptidase inhibitor; hydroxychloroquine; immunoglobulin; lopinavir plus ritonavir; steroid; vasoactive agent; acute heart infarction; acute kidney failure; adult; adult respiratory distress syndrome; aged; antibiotic therapy; antihypertensive therapy; antiviral therapy; Article; artificial ventilation; brain damage; brain hypoxia; brain injury; clinical article; conservative treatment; continuous renal replacement therapy; controlled study; coronavirus disease 2019; critically ill patient; death; disease course; disease severity assessment; disseminated intravascular clotting; extracorporeal oxygenation; female; heart injury; hospital; hospital mortality; human; hypertension; immunotherapy; lung hemorrhage; male; mesenteric ischemia; mortality rate; multiple organ failure; pneumothorax; priority journal; retrospective study; seizure; septic shock; South Korea; steroid therapy; vasoactive inotropic score; veno-arterial ECMO; veno-venous ECMO; ventilator weaning; clinical trial; middle aged; multicenter study; pandemic | English | 2021 | 2021 (JAN-FEB) | 10.1016/j.hrtlng.2020.10.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Laparoscopic Multivisceral Resection With Fluorescence-Guided Para-Aortic Lymph Node Dissection for Advanced T4b Colon Cancer | Kim, Hye Jin; Song, Seung Ho; Choi, Gyu-Seog; Park, Jun Seok; Park, Soo Yeun | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, Daegu, South Korea | ; Kim, Hye/W-1059-2019; Park, Joonhong/AAZ-9885-2020 | 57204567554; 57221771693; 8058759100; 35226761100; 40561578300 | kyuschoi@mail.knu.ac.kr; | DISEASES OF THE COLON & RECTUM | DIS COLON RECTUM | 0012-3706 | 1530-0358 | 64 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 4.657 | 14.8 | 0.11 | 2025-07-30 | 0 | 1 | Advanced colon cancer; Laparoscopy; Multivisceral resection; Para-aortic lymph node dissection; Preoperative chemotherapy | Advanced colon cancer; Laparoscopy; Multivisceral resection; Para-aortic lymph node dissection; Preoperative chemotherapy | Aorta; Colectomy; Colonic Neoplasms; Humans; Laparoscopy; Lymph Node Excision; Neoplasm Invasiveness; Neoplasm Staging; Optical Imaging; Spectroscopy, Near-Infrared; Surgery, Computer-Assisted; indocyanine green; advanced cancer; cancer staging; cancer surgery; colon cancer; Conference Paper; fluorescence; human; laparoscopy; lymph node dissection; neoplasm; preoperative chemotherapy; surgery; aorta; case report; colon resection; colon tumor; computer assisted surgery; diagnostic imaging; fluorescence imaging; laparoscopy; lymph node dissection; near infrared spectroscopy; pathology; procedures; tumor invasion | English | 2021 | 2021-02 | 10.1097/dcr.0000000000001902 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prognostic Value of Venous Invasion Detected by Elastin Stain May Surpass Lymph Node Status in Colon Cancer | BACKGROUND: Venous invasion is a poor prognostic factor in colon cancer but is often underreported with significant variability. OBJECTIVES: We aimed to determine the impact of an elastin stain on venous invasion detection in colon cancer and evaluate the value of venous invasion in predicting disease recurrence in combination with lymph node status and other prognostic factors. DESIGN: This is a retrospective analysis of a prospectively collected database. SETTING: This study was conducted at a tertiary cancer center. PATIENTS: A total of 418 patients who underwent curative resection for stage I to III colon cancer and routinely adopted an elastin stain were evaluated. MAIN OUTCOME MEASURES: Venous invasion detection rate after adopting elastin stain, prognostic factors influencing disease recurrences by multivariate Cox regression models, and survival were measured. The zones of lymph node metastasis were defined as LNZ1, LNZ2, and LNZ3, corresponding to metastases in the pericolic, intermediate, and apical nodes. RESULTS: Venous invasion detection rate increased from 11.3% to 35.4% compared with the previous period in which only hematoxylin and eosin stain was performed. Cox regression analysis showed venous invasion (HR, 3.856; 95% CI, 1.249-11.910; p = 0.019) and lymph node metastases (HR, 3.156; 95% CI, 1.094-9.108; p = 0.034) in all stages and LNZ 2, 3 (HR, 2.649; 95% CI, 1.244-5.640; p = 0.012) in stage III to be significantly associated with poor disease-free survival. When stratifying all patients by these 3 factors, patients with stage III [LNZ1/venous invasion (-)] had disease-free survival comparable with stage I, but significantly better disease-free survival than those with stage II [venous invasion (+)] (p = 0.018). Patients with stage II [venous invasion (+)] had better disease-free survival by using adjuvant chemotherapy (p < 0.001). LIMITATIONS: This study was limited by its retrospective design. CONCLUSION: Elastin stain contributed to a considerable increase in venous invasion detection. Venous invasion can be a powerful predictor of poor disease-free survival beyond lymph node metastases when limited to the pericolic area and is useful for deciding the use of adjuvant chemotherapy in stage II colon cancer. | Kim, Hye Jin; Choi, Gyu-Seog; Seo, An Na; Park, Jun Seok; Park, Soo Yeun; Cho, Seung Hyun; Yoon, Ghilsuk | Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Radiol, Sch Med, Daegu, South Korea | Park, Joonhong/AAZ-9885-2020; Kim, Hye/W-1059-2019 | 57204567554; 8058759100; 55804153700; 35226761100; 40561578300; 55686242700; 57204691355 | kyuschoi@mail.knu.ac.kr; | DISEASES OF THE COLON & RECTUM | DIS COLON RECTUM | 0012-3706 | 1530-0358 | 64 | 8 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 4.657 | 14.8 | 0.49 | 2025-07-30 | 6 | 6 | Adjuvant chemotherapy; Colon cancer; Elastin stain; Lymph node metastasis; Survival; Venous invasion | LOW ANTERIOR RESECTION; LOW RECTAL-CANCER; COLORECTAL ANASTOMOTIC STENOSIS; RISK-FACTORS; INTERSPHINCTERIC RESECTION; DEFUNCTIONING STOMA; LEAKAGE; STRICTURE; IMPACT; COMPLICATIONS | Adjuvant chemotherapy; Colon cancer; Elastin stain; Lymph node metastasis; Survival; Venous invasion | Aged; Biomarkers, Tumor; Blood Vessels; Colonic Neoplasms; Disease-Free Survival; Elastin; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Retrospective Studies; Staining and Labeling; elastin; tumor marker; aged; blood vessel; colon tumor; diagnosis; disease free survival; female; human; lymph node metastasis; male; middle aged; mortality; pathology; prognosis; retrospective study; staining; tumor invasion | English | 2021 | 2021-08 | 10.1097/dcr.0000000000001968 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Robot Surgery Shows Similar Long-term Oncologic Outcomes as Laparoscopic Surgery for Mid/Lower Rectal Cancer but Is Beneficial to ypT3/4 After Preoperative Chemoradiation | BACKGROUND: The long-term oncologic efficacy of robotic surgery for patients with rectal cancer is unknown. OBJECTIVE: The aim of the study was to investigate survival outcomes of robotic total mesorectal excision for mid/low rectal cancer compared with those of laparoscopic surgery. DESIGN: We performed a single-center retrospective analysis. SETTING: The data of a tertiary academic institution was reviewed. PATIENTS: A total of 705 patients underwent laparoscopic (n = 415) or robotic (n = 118) low anterior resection for stage I to III mid/low rectal cancer. A total of 118 patients in each group were selected from the original data set by using propensity score matching. MAIN OUTCOME MEASURES: The main outcomes were 5-year disease-free survival, distant recurrence, and local recurrence. RESULTS: The 2 groups were balanced in terms of basic characteristics, perioperative treatment, and pathological stage. The 5-year disease-free survival rate was 80.5% in the laparoscopic group and 87.6% in the robotic group (p = 0.118). The 5-year distant recurrence rate and local recurrence rate were 19.0% and 4.2% in the laparoscopic group and 10.0% and 3.7% in the robotic group (p = 0.048 and p = 0.846). In a subgroup of patients who received preoperative chemoradiation and had ypT3/4 tumors, the 5-year distant recurrence and local recurrence rates were 44.8% and 5.0% in the laparoscopic group and 9.8% and 9.8% in the robotic group (p = 0.014 and p = 0.597). LIMITATIONS: The retrospective nature of the study, potential selection bias with distinct demographics between the groups, and relatively small number of cases are limitations. CONCLUSIONS: Robotic surgery for mid/low rectal cancer shows similar long-term oncologic outcomes with laparoscopic surgery but is beneficial to a certain group of patients with advanced rectal cancer with poor response to neoadjuvant chemoradiation. Additional studies are required to confirm our results. | Park, Soo Yeun; Lee, Sung Min; Park, Jun Seok; Kim, Hye Jin; Choi, Gyu-Seog | Kyungpook Natl Univ, Chilgok Hosp, Dept Surg, Colorectal Canc Ctr,Sch Med, Daegu, South Korea | Kim, Hye/W-1059-2019; Park, Joonhong/AAZ-9885-2020 | 40561578300; 55236751200; 35226761100; 57204567554; 8058759100 | kyuschoi@mail.knu.ac.kr; | DISEASES OF THE COLON & RECTUM | DIS COLON RECTUM | 0012-3706 | 1530-0358 | 64 | 7 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 4.657 | 14.8 | 1.76 | 2025-07-30 | 24 | 21 | Rectal cancer; Recurrence; Robotic surgery; Survival | TOTAL MESORECTAL EXCISION; ASSISTED RESECTION; INTERSPHINCTERIC RESECTION; PATHOLOGICAL OUTCOMES; OPEN-LABEL; SURVIVAL; RADIOTHERAPY; CHEMORADIOTHERAPY; METASTASIS; RECURRENCE | Rectal cancer; Recurrence; Robotic surgery; Survival | Aged; Chemoradiotherapy; Disease-Free Survival; Female; Humans; Laparoscopy; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Outcome Assessment, Health Care; Preoperative Care; Proctectomy; Propensity Score; Rectal Neoplasms; Retrospective Studies; Robotic Surgical Procedures; aged; cancer staging; chemoradiotherapy; comparative study; disease free survival; epidemiology; female; human; laparoscopy; male; middle aged; pathology; preoperative care; procedures; propensity score; rectum resection; rectum tumor; retrospective study; robot assisted surgery; tumor recurrence | English | 2021 | 2021-07 | 10.1097/dcr.0000000000001978 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Single-Port Robotic Low Anterior Resection With Lateral Pelvic Node Dissection in Locally Advanced Rectal Cancer | Kim, Hye Jin; Choi, Gyu-Seog | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, Daegu, South Korea | Kim, Hye/W-1059-2019 | 57204567554; 8058759100 | kyuschoi@mail.knu.ac.kr; | DISEASES OF THE COLON & RECTUM | DIS COLON RECTUM | 0012-3706 | 1530-0358 | 64 | 12 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 4.657 | 14.8 | 0.1 | 2025-07-30 | 3 | 2 | Locally advanced rectal cancer; Robotic surgery; Single-port robot; Single-port robotic lateral pelvic lymph node dissection; Single-port robotic low anterior resection | Locally advanced rectal cancer; Robotic surgery; Single-port robot; Single-port robotic lateral pelvic lymph node dissection; Single-port robotic low anterior resection | Dissection; Humans; Ligation; Lymph Node Excision; Lymph Nodes; Male; Mesenteric Artery, Inferior; Middle Aged; Pelvis; Proctectomy; Rectal Neoplasms; Robotic Surgical Procedures; Severity of Illness Index; Treatment Outcome; case report; dissection; human; inferior mesenteric artery; ligation; lymph node; lymph node dissection; male; middle aged; pathology; pelvis; procedures; rectum resection; rectum tumor; robot assisted surgery; severity of illness index; treatment outcome | English | 2021 | 2021-12 | 10.1097/dcr.0000000000002170 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus-related hepatocellular carcinoma | Background/aims: Whether entecavir (ETV) or tenofovir disoproxil fumarate (TDF) affords the better prognosis after curative treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear. We compared recurrence and death rates between patients taking ETV and those taking TDF. Methods: Between 2013 and 2017, patients with HBV-related HCC who had undergone hepatic resection (n=421) or radiofrequency ablation (n=305) as first-line anti-HCC treatment in three institutes were consecutively enrolled. All patients received ETV or TDF as a first-line antiviral. The cumulative probabilities of recurrence and death were assessed. We adjusted for viral factors, including the HBV-DNA load, and tumor and demographic factors. Results: During the study period (median 46.6 [interquartile range 25.3-58.9] months), 227 patients experienced recurrence and 53 died. In the ETV (n=405) and TDF (n=321) groups, the annual incidences of recurrence (10.61 and 11.21 per 100 person-years, respectively; P=727) and death (2.28 and 1.79 per 100 person-years, respectively; P=277) were similar, with adjusted hazard ratios (aHRs) of 0.932 (P=0.622) and 0.667 (P=0.193), respectively. When stratified by treatment modality and the timing of antiviral therapy commencement, the values were similar (all P>0.05). Inverse probability of treatment weighting (IPTW) analyses yielded results that were similar in the two groups in terms of recurrence (aHR=1.038, P=0.963) and death (aHR=0.799, P=0.431). Furthermore, the early (= 2 years) recurrence risks were not statistically different in the two groups (both P=0.400), as confirmed by IPTW analysis (P=0.502 and P=0.377, respectively). Conclusions: The prognoses in terms of recurrence and death after curative treatment of HBV-related HCC were not statistically different between the ETV and TDF groups. Further validation studies are needed. | Lee, Ji Hyun; Kim, Beom Kyung; Park, Soo Young; Tak, Won Young; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Sinn, Dong Hyun; Kim, Seung Up | Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Coll Med, 81 Irwon Ro, Seoul 06351, South Korea | Kim, Kyung/I-5501-2015; Kim, Sun/L-4239-2013; Ahn, Sang Hoon/AFM-2603-2022; SANG-HOON, AHN/AAV-2600-2020; Park, Jun/H-7127-2019; Sinn, Dong/JAC-4247-2023 | 57268971500; 35302925200; 57191674344; 7004074582; 47861376300; 56119929100; 7401989551; 23493891100; 54933821200 | dh.sinn@samsung.com;ksukorea@yuhs.ac; | EUROPEAN JOURNAL OF INTERNAL MEDICINE | EUR J INTERN MED | 0953-6205 | 1879-0828 | 89 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 7.749 | 14.8 | 2.56 | 2025-07-30 | 29 | 31 | Entecavir; Tenofovir; Hepatocellular carcinoma; Curative; Treatment; Prognosis | ANTIVIRAL THERAPY; HBV GENOTYPES; RISK; RESECTION; ANALOGS | Curative; Entecavir; Hepatocellular carcinoma; Prognosis; Tenofovir; Treatment | Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Tenofovir; Treatment Outcome; alanine aminotransferase; alpha fetoprotein; decarboxyprothrombin; entecavir; hepatitis B(e) antigen; serum albumin; tenofovir disoproxil; virus DNA; antivirus agent; entecavir; guanine; tenofovir; adult; alanine aminotransferase level; albumin blood level; alcohol liver disease; alpha fetoprotein blood level; antiviral therapy; Article; cancer diagnosis; cancer mortality; cancer prognosis; cancer recurrence; cancer size; cancer surgery; cancer survival; cohort analysis; controlled study; diabetes mellitus; drug efficacy; female; follow up; hepatitis B; Hepatitis B virus; human; hypertension; liver cell carcinoma; liver cirrhosis; liver resection; major clinical study; male; middle aged; mortality rate; multicenter study; nonhuman; protein blood level; radiofrequency ablation; recurrence free survival; recurrence risk; recurrent disease; recurrent infection; tumor ablation; tumor number; tumor volume; virus load; chronic hepatitis B; complication; Hepatitis B virus; liver cell carcinoma; liver tumor; prognosis; retrospective study; treatment outcome; tumor recurrence | English | 2021 | 2021-07 | 10.1016/j.ejim.2021.02.019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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