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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Nontargeted Metabolomics by High-Resolution Mass Spectrometry to Study the In Vitro Metabolism of a Dual Inverse Agonist of Estrogen-Related Receptors β and γ, DN203368 DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor beta/gamma (ERR beta/gamma). ERR gamma is an orphan nuclear receptor that plays an important role in development and homeostasis and holds potential as a novel therapeutic target in metabolic diseases such as diabetes mellitus, obesity, and cancer. ERR beta is also one of the orphan nuclear receptors critical for many biological processes, such as development. We investigated the in vitro metabolism of DN203368 by conventional and metabolomic approaches using high-resolution mass spectrometry. The compound (100 mu M) was incubated with rat and human liver microsomes in the presence of NADPH. In the metabolomic approach, the m/z value and retention time information obtained from the sample and heat-inactivated control group were statistically evaluated using principal component analysis and orthogonal partial least-squares discriminant analysis. Significant features responsible for group separation were then identified using tandem mass spectra. Seven metabolites of DN203368 were identified in rat liver microsomes and the metabolic pathways include hydroxylation (M1-3), N-oxidation (M4), N-deisopropylation (M5), N,N-dealkylation (M6), and oxidation and dehydrogenation (M7). Only five metabolites (M2, M3, and M5-M7) were detected in human liver microsomes. In the conventional approach using extracted ion monitoring for values of mass increase or decrease by known metabolic reactions, only five metabolites (M1-M5) were found in rat liver microsomes, whereas three metabolites (M2, M3, and M5) were found in human liver microsomes. This study revealed that nontargeted metabolomics combined with high-resolution mass spectrometry and multivariate analysis could be a more efficient tool for drug metabolite identification than the conventional approach. These results might also be useful for understanding the pharmacokinetics and metabolism of DN203368 in animals and humans. Kim, Sin-Eun; Ji, Seung-Bae; Kim, Euihyeon; Jeong, Minseon; Kim, Jina; Lee, Gyung-Min; Seo, Hyung-Ju; Bae, Subin; Jeong, Yeojin; Lee, Sangkyu; Kim, Sunghwan; Lee, Taeho; Cho, Sung Jin; Liu, Kwang-Hyeon Kyungpook Natl Univ, Coll Pharm, BK21 FOUR KNU Community Based Intelligent Novel D, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea ; Kim, Sunghwan/HKN-9812-2023 57217828200; 57217827900; 57224532558; 59841337200; 56949261900; 57217829865; 57204496397; 57224532908; 57224538974; 57209046767; 57203772967; 57204032003; 58735369700; 55768214700 hjkopsty@gmail.com;wltmdqo2377@naver.com;uihyeon1112@naver.com;dha66@dgmif.re.kr;jina@dgmif.re.kr;lgm00179@naver.com;hlhl103@naver.com;bsb960908@naver.com;duwls9902@naver.com;sangkyu@knu.ac.kr;sunghwank@knu.ac.kr;tlee@knu.ac.kr;sjcho@kist.re.kr;dstlkh@knu.ac.kr; PHARMACEUTICS PHARMACEUTICS 1999-4923 13 6 SCIE PHARMACOLOGY & PHARMACY 2021 6.525 13.8 0.09 2025-07-30 2 2 estrogen-related receptor gamma; inverse agonist; liquid chromatography-tandem mass spectrometry; metabolite identification; metabolomics MS-BASED METABOLOMICS; ERR-GAMMA; TAMOXIFEN; RAT; BIOTRANSFORMATION; IDENTIFICATION; EXPRESSION; REGULATOR; MOUSE; VIVO Estrogen-related receptor γ; Inverse agonist; Liquid chromatography–tandem mass spectrometry; Metabolite identification; Metabolomics 3 [1 [4 (4 isopropylpiperazine 1 yl)phenyl] 3 methyl 2 phenylbut 1 en 1 yl]phenol; 3 [3 methyl 2 phenyl 1 [4 (piperazin 1 yl)phenyl]but 1 en 1 yl]phenol; 4 [4 [1 (3 hydroxyphenyl) 3 methyl 2 phenylbut 1 en 1 yl]phenyl] 1 isopropylpiperazine 1 oxide; dn 203368; estrogen receptor; estrogen receptor beta; estrogen receptor gamma; steroid hormone receptor stimulating agent; unclassified drug; animal cell; animal experiment; Article; chemical reaction; controlled study; dealkylation; dehydrogenation; deisopropylation; drug metabolism; drug oxidation; drug structure; drug transformation; human; human cell; hydroxylation; in vitro study; ion monitoring; liver microsome; mass spectrometry; metabolomics; mouse; nonhuman; principal component analysis; retention time English 2021 2021-06 10.3390/pharmaceutics13060776 바로가기 바로가기 바로가기 바로가기
Article Ordered LiNi0.5Mn1.5O4 Cathode in Bis(fluorosulfonyl)imide-Based Ionic Liquid Electrolyte: Importance of the Cathode-Electrolyte Interphase The high-voltage (4.7 V vs Li+/Li) spinel lithium nickel manganese oxide (LiNi0.5Mn1.5O4, LNMO) is a promising candidate for the next generation of lithium-ion batteries due to its high energy density, low cost, and low environmental impact. However, poor cycling performance at high cutoff potentials limits its commercialization. Herein, hollow-structured LNMO is synergistically paired with an ionic liquid electrolyte, 1 M lithium bis(fluorosulfonyl)imide (LiFSI) in N-propyl-N-methylpyrrolidinium bis( fluorosulfonyl)imide (Pyr(1,3)FSI), to achieve stable cycling performance and improve the rate capability. The optimized cathode-electrolyte system exhibits extended cycling performance (>85% capacity retention after 300 cycles) and high rate performance (106.2 mAh g(-1) at 5C) even at an elevated temperature of 65 degrees C. X-ray photoelectron spectroscopy and spatially resolved X-ray fluorescence analyses confirm the formation of a robust, LiF-rich cathode-electrolyte interphase. This study presents a comprehensive design strategy to improve the electrochemical performance of high-voltage cathode materials. Lee, Hyeon Jeong; Brown, Zachary; Zhao, Ying; Fawdon, Jack; Song, Weixin; Lee, Ji Hoon; Ihli, Johannes; Pasta, Mauro Univ Oxford, Dept Mat, Oxford OX1 3PH, England; Tongji Univ, Dept Aerosp Engn & Appl Mech, Shanghai 200092, Peoples R China; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Paul Scherrer Inst, CH-5232 Villigen, Switzerland ; Zhao, Ying/AAI-4406-2020; Ihli, Johannes/G-1767-2015; Lee, Ji Hoon/T-4913-2017; Song, Weixin/C-6722-2012; Lee, Ji/AAU-7285-2021; Pasta, Mauro/B-8164-2012 56711412600; 56266372200; 56895412200; 57204219801; 55498690000; 55689885200; 55625772100; 24503276200 mauro.pasta@materials.ox.ac.uk; CHEMISTRY OF MATERIALS CHEM MATER 0897-4756 1520-5002 33 4 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY 2021 10.508 13.8 1.4 2025-07-30 28 26 LONG-CYCLE LIFE; ELECTROCHEMICAL PROPERTIES; LITHIUM; SPINEL; BATTERIES; TEMPERATURE; PERFORMANCE; STABILITY; OXIDATION; LAYER Cathodes; Electrolytes; Environmental impact; Fluorescence; Iodine compounds; Ionic liquids; Lithium compounds; Lithium-ion batteries; Manganese oxide; Nickel oxide; Sulfur compounds; X ray photoelectron spectroscopy; Bis(fluorosulfonyl)imide; Comprehensive designs; Electrochemical performance; High energy densities; High-rate performance; Ionic liquid electrolytes; Lithium nickel manganese oxides; X ray fluorescence analysis; Fluorine compounds English 2021 2021-02-23 10.1021/acs.chemmater.0c04014 바로가기 바로가기 바로가기 바로가기
Article Patients' and Families' Experiences Regarding Disclosure of Patient Safety Incidents In South Korea, disclosure of patients' safety incidents is not common in health care settings. Thus, this study identified patients' and families' experiences regarding disclosure of patient safety incidents. Data were collected through in-depth individual interviews from May 25, 2020, to June 23, 2020, and analyzed using Colaizzi's phenomenological method. The participants consisted of 15 patients and their families who had experienced patient safety incidents in hospitals. It is essential to form a base of mutual understanding to enable disclosure and promote follow-up management systems that can ethically and responsibly handle patient safety incidents. Concrete protocols and policies need to be developed to protect patients and their families from physical/psychological injury and the stress experienced due to patient safety incidents. The patients and their families desired changes to improve protocols for proper disclosure, help health care professionals adopt an ethical and mature attitude, and develop professional health care policies regarding patients' safety incidents. Kim, Yujeong; Lee, Eunmi Kyungpook Natl Univ, Daegu, South Korea; Hoseo Univ, Asan, South Korea Lee, Eunmi/AAS-2561-2020 57200941945; 57202264064 sweetbear2@hanmail.net; QUALITATIVE HEALTH RESEARCH QUAL HEALTH RES 1049-7323 1552-7557 31 13 SSCI INFORMATION SCIENCE & LIBRARY SCIENCE;SOCIAL SCIENCES, BIOMEDICAL;SOCIAL SCIENCES, INTERDISCIPLINARY 2021 4.233 13.8 0.78 2025-07-30 7 9 safety incidents; patient safety; disclosure; qualitative research; qualitative; South Korea MORAL SENSITIVITY; MEDICAL ERRORS disclosure; patient safety; qualitative; qualitative research; safety incidents; South Korea Disclosure; Health Personnel; Hospitals; Humans; Patient Safety; Republic of Korea; health care personnel; hospital; human; interpersonal communication; patient safety; South Korea English 2021 2021-11 10.1177/10497323211037634 바로가기 바로가기 바로가기 바로가기
Editorial Material Pharmacokinetic Drug-Drug Interactions and Herb-Drug Interactions Choi, Min-Koo; Song, Im-Sook Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Vessel Organ Interact Res Ctr VOICE, Res Inst Pharmaceut Sci,Coll Pharm, Daegu 41566, South Korea 8695781400; 7201564500 minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; PHARMACEUTICS PHARMACEUTICS 1999-4923 13 5 SCIE PHARMACOLOGY & PHARMACY 2021 6.525 13.8 3.97 2025-07-30 9 10 ABC transporter subfamily B; alcohol; amfebutamone; berberine; beroline; beta adrenergic receptor blocking agent; breast cancer resistance protein; caffeine; calcitriol; cisplatin; clopidogrel; codeine; creatine kinase; creatinine; cytochrome P450; cytochrome P450 2B; cytochrome P450 2C; cytochrome P450 2C19; cytochrome P450 2D6; cytochrome P450 3A4; demethyleneberberine; demethylenethalifendine; dextromethorphan; diclofenac; digoxin; drug metabolizing enzyme; dutasteride; fenofibrate; flavonoid; fluoxetine; furosemide; glucuronide; glucuronosyltransferase; grape pomace extract; histamine H1 receptor antagonist; ketoconazole; metformin; methotrexate; methylenedioxybenzene; mulberry extract; nifedipine; norfluoxetine; omeprazole; organic anion transporter; organic cation transporter; paracetamol; pitavastatin; plant extract; probenecid; solute carrier organic anion transporter 1B1; sorafenib; terpenoid; thalifendine; tolbutamide; tramadol; tricyclic antidepressant agent; unclassified drug; urea; valsartan; aging; antidiabetic activity; area under the curve; biological model; clinical study; cognitive defect; comparative study; creatinine blood level; differentiated thyroid cancer; disease severity; drug absorption; drug accumulation; drug blood level; drug efficacy; drug elimination; drug exposure; drug fatality; drug metabolism; drug potentiation; drug protein binding; drug safety; drug structure; drug uptake; Editorial; elimination half-life; enterohepatic circulation; enzyme activity; enzyme inhibition; enzyme mechanism; herbal medicine; histopathology; hospital admission; hospital discharge; human; in vitro study; in vivo study; intrinsic clearance; keratinocyte; kidney function; kidney injury; Korean (people); liver cell; liver cell carcinoma; liver metabolism; liver microsome; maximum plasma concentration; monotherapy; mortality; nephrotoxicity; nonhuman; pharmacodynamic parameters; pharmacokinetic parameters; phase 1 clinical trial (topic); phytochemistry; plant leaf; polypharmacy; postoperative period; prediction; preoperative period; prescription; proof of concept; protein binding; protein expression; randomized controlled trial (topic); side effect; small intestine absorption; steady state; stomach absorption; streptozotocin-induced diabetes mellitus; therapy effect; thorax surgery; thrombocyte aggregation; treatment outcome; United States; urea blood level; volunteer English 2021 2021-05 10.3390/pharmaceutics13050610 바로가기 바로가기 바로가기 바로가기
Article Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis Prostate and breast cancer are the current leading causes of new cancer cases in males and females, respectively. Phosphatidylserine (PS) is an essential lipid that mediates macrophage efferocytosis and is dysregulated in tumors. Therefore, developing therapies that selectively restore PS may be a potential therapeutic approach for carcinogenesis. Among the nanomedicine strategies for delivering PS, biocompatible gold nanoparticles (AuNPs) have an extensive track record in biomedical applications. In this study, we synthesized biomimetic phosphatidylserine-caped gold nanoparticles (PS-AuNPs) and tested their anticancer potential in breast and prostate cancer cells in vitro. We found that both cell lines exhibited changes in cell morphology indicative of apoptosis. After evaluating for histone-associated DNA fragments, a hallmark of apoptosis, we found significant increases in DNA fragmentation upon PS-AuNP treatment compared to the control treatment. These findings demonstrate the use of phosphatidylserine coupled with gold nanoparticles as a potential treatment for prostate and breast cancer. To the best of our knowledge, this is the first time that a phosphatidylserine-capped AuNP has been examined for its therapeutic potential in cancer therapy. Radaic, Allan; Joo, Nam E.; Jeong, Soo-Hwan; Yoo, Seong-, II; Kotov, Nicholas; Kapila, Yvonne L. Univ Calif San Francisco UCSF, Sch Dent, Orofacial Sci Dept, San Francisco, CA 94143 USA; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Polymer Engn, Busan 608737, South Korea; Univ Michigan, Coll Engn, Dept Chem Engn, Ann Arbor, MI 48109 USA Kotov, Nicholas/AAZ-4204-2021; Kapila, Yvonne/AAG-5418-2021; , SooHwanJeong/JOJ-6732-2023; Radaic, Allan/J-5354-2018 55839010900; 6603884597; 7402425359; 24475949500; 22135180200; 6603814821 allan.radaic@ucsf.edu;nejoo9136@gmail.com;shjeong@knu.ac.kr;siyoo@pknu.ac.kr;kotov@umich.edu;yvonne.kapila@ucsf.edu; PHARMACEUTICS PHARMACEUTICS 1999-4923 13 7 SCIE PHARMACOLOGY & PHARMACY 2021 6.525 13.8 0.92 2025-07-30 15 14 gold nanoparticles; phosphatidylserine; PS-AuNP; breast cancer; prostate cancer; apoptosis PHAGOCYTOSIS; MEMBRANES; LINES; HEAD Apoptosis; Breast cancer; Gold nanoparticles; Phosphatidylserine; Prostate cancer; PS-AuNP DNA; gold nanoparticle; phosphatidylserine; antineoplastic activity; apoptosis; Article; breast cancer cell line; cell structure; controlled study; DNA fragmentation; drug formulation; drug synthesis; human; human cell; in vitro study; nanomedicine; proof of concept; prostate cancer cell line English 2021 2021-07 10.3390/pharmaceutics13071094 바로가기 바로가기 바로가기 바로가기
Article Stellar interferometry for gravitational waves We propose a new method to detect gravitational waves, based on spatial coherence interferometry with stellar light, as opposed to the conventional temporal coherence interferometry with laser sources. The proposed method detects gravitational waves by using two coherent beams of light from a single distant star measured at separate space-based detectors with a long baseline. This method can be applied to either the amplitude or intensity interferometry. This experiment allows for the search of gravitational waves in the lower frequency range of 10(-6) to 10(-4) Hz. In this work, we present the detection sensitivity of the proposed stellar interferometer by taking the detector response and shot and acceleration noises into account. Furthermore, the proposed experimental setup is capable of searching for primordial black holes and studying the size of the target neutron star, which are also discussed in the paper. Park, I. H.; Choi, K-Y; Hwang, J.; Jung, S.; Kim, D. H.; Kim, M. H.; Lee, C-H; Lee, K. H.; Oh, S. H.; Park, M-G; Park, S. C.; Pozanenko, A.; Rho, C. D.; Vedenkin, N.; Won, E. Sungkyunkwan Univ SKKU, Dept Phys, 2066 Seobu Ro, Suwon 16419, South Korea; Seoul Natl Univ, Ctr Theoret Phys, Dept Phys & Astron, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Dept Phys & Astron, Astron Program, 1 Gwanak Ro, Seoul 08826, South Korea; Pusan Natl Univ, Dept Phys, 2 Busandaehak Ro 63Beon Gil, Busan 46241, South Korea; Natl Inst Math Sci, Div Fundamental Res Publ Agenda, 70 Yuseong Daero 1689 Beon Gil, Daejeon 34047, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, 80 Daehak Ro, Daegu 41566, South Korea; Yonsei Univ, Dept Phys, 50 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, IPAP, 50 Yonsei Ro, Seoul 03722, South Korea; Russian Acad Sci IKI, Space Res Inst, 84-32 Profsoyuznaya Str, Moscow 117997, Russia; Natl Res Univ, Higher Sch Econ, Myasnitskaya 20, Moscow 101000, Russia; Moscow Inst Phys & Technol MIPT, 9 Inst Skiy,Pereulok St, Dolgoprudnyi 141701, Russia; Univ Seoul, Nat Sci Res Inst, 163 Seoulsiripdaero, Seoul 02504, South Korea; Korea Univ, Dept Phys, 145 Anam Ro, Seoul 02841, South Korea ; Park, Hae/AAM-2956-2021; Jung, Sunghoon/GLS-8779-2022; Choi, Ki-Young/H-3305-2012; Oh, Sang-Hwan/KIL-5347-2024; Won, Eunil/S-7182-2019; Pozanenko, Alexei/ABA-9307-2021 56419230500; 21735854300; 8287965300; 24780929300; 57221129747; 57839652900; 57196256122; 59613766600; 55570137900; 7404490321; 55177359000; 6508296997; 57194577088; 21733877200; 35274124300 ilparksk@ku.edu;kiyoungchoi@skku.edu;jungseek@skku.edu;sunghoonj@snu.ac.kr;kil313@yahoo.com;vader0210@gmail.com;clee@pusan.ac.kr;lkh6670@naver.com;shoh@nims.re.kr;mgp@knu.ac.kr;sc.oark@yonsei.ac.kr;apozanen@iki.rssi.ru;cdr397@uos.ac.kr;vnn.space@gmail.com;eunilwon@korea.ac.kr; JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS J COSMOL ASTROPART P 1475-7516 11 SCIE ASTRONOMY & ASTROPHYSICS;PHYSICS, PARTICLES & FIELDS 2021 7.28 13.8 0.54 2025-07-30 13 9 gravitational wave detectors; gravitational waves / experiments BLACK-HOLE Experiments; Gravitational wave detectors; Gravitational waves English 2021 2021-11 10.1088/1475-7516/2021/11/008 바로가기 바로가기 바로가기 바로가기
Article Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes Eudesmin, fargesin, epimagnolin A, magnolin, and yangambin are tetrahydrofurofuranoid lignans with various pharmacological activities found in Magnoliae Flos. The inhibition potencies of eudesmin, fargesin, epimagnolin A, magnolin, and yangambin on six major human uridine 5 '-diphospho-glucuronosyltransferase (UGT) activities in human liver microsomes were evaluated using liquid chromatography-tandem mass spectrometry and cocktail substrates. Eudesmin, fargesin, epimagnolin A, magnolin, and yangambin inhibited UGT1A1 and UGT1A3 activities, but showed negligible inhibition of UGT1A4, UGT16, UGT1A9, and UGT2B7 activities at 200 mu M in pooled human liver microsomes. Moreover, eudesmin, fargesin, epimagnolin A, magnolin, and yangambin noncompetitively inhibited UGT1A1-catalyzed SN38 glucuronidation with K-i values of 25.7, 25.3, 3.6, 26.0, and 17.1 mu M, respectively, based on kinetic analysis of UGT1A1 inhibition in pooled human liver microsomes. Conversely, the aforementioned tetrahydrofurofuranoid lignans competitively inhibited UGT1A3-catalyzed chenodeoxycholic acid 24-acyl-glucuronidation with 39.8, 24.3, 15.1, 37.6, and 66.8 mu M, respectively in pooled human liver microsomes. These in vitro results suggest the necessity of evaluating whether the five tetrahydrofurofuranoid lignans can cause drug-drug interactions with UGT1A1 and UGT1A3 substrates in vivo. Park, Ria; Park, Eun Jeong; Cho, Yong-Yeon; Lee, Joo Young; Kang, Han Chang; Song, Im-Sook; Lee, Hye Suk Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea Kang, Han/I-5999-2019; Cho, Yong-Yeon/AAD-4263-2020 57215577826; 58333586800; 55472207900; 57215684977; 36150873700; 7201564500; 35316111800 hyacinthy7@catholic.ac.kr;enddl0818@catholic.ac.kr;yongyeon@catholic.ac.kr;joolee@catholic.ac.kr;hckang@catholic.ac.kr;isssong@knu.ac.kr;sianalee@catholic.ac.kr; PHARMACEUTICS PHARMACEUTICS 1999-4923 13 2 SCIE PHARMACOLOGY & PHARMACY 2021 6.525 13.8 1.01 2025-07-30 9 13 eudesmin; fargesin; epimagnolin A; magnolin; yangambin; human liver microsomes; UDP-glucuronosyltransferase Epimagnolin A; Eudesmin; Fargesin; Human liver microsomes; Magnolin; UDP-glucuronosyltransferase; Yangambin epimagnolin A; eudesmin; fargesin; glucuronosyltransferase 1A1; glucuronosyltransferase 1A3; glucuronosyltransferase 1A4; glucuronosyltransferase 1A9; glucuronosyltransferase 2B7; lignan derivative; liver protective agent; magnolin; tetrahydrofurofuranoid; unclassified drug; yangambin; Article; cell protection; controlled study; drug potency; enzyme activity; enzyme inhibition; enzyme kinetics; glucuronidation; human; human cell; IC50; in vitro study; liquid chromatography; liver microsome; liver protection; tandem mass spectrometry English 2021 2021-02 10.3390/pharmaceutics13020187 바로가기 바로가기 바로가기 바로가기
Article Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers Pharmacometabolomics is a useful tool to identify biomarkers that can assess and predict response after drug administration. The primary purpose of pharmacometabolomics is to better understand the mechanisms and pathways of a drug by searching endogenous metabolites that have significantly changed after drug administration. DA-9701, a prokinetic agent, consists of Pharbitis seed and Corydalis tube extract and it is known to improve the gastrointestinal motility. Although the overall mechanism of action of DA-9701 remains unclear, its active ingredients, corydaline and chlorogenic acid, act as a 5-HT3 and D2 receptor antagonist and 5-HT4 receptor agonist. To determine the significant metabolites after the administration of DA-9701, a qualitative analysis was carried out using ultra-high performance liquid chromatography coupled with orbitrap mass spectrometer followed by a multivariate analysis. Seven candidates were selected and a statistical analysis of fold change was performed over time. Our study concluded that all the seven selected metabolites were commonly involved in lipid metabolism and purine metabolism. Jeong, Hyeon-Cheol; Park, Jung Eun; Seo, Yohan; Kim, Min-Gul; Shin, Kwang-Hee Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu 41566, South Korea; New Drug Dev Ctr, Daegu 41061, South Korea; Jeonbuk Natl Univ Hosp, Ctr Clin Pharmacol, Jeonju 54907, South Korea; Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Sch Med, Dept Pharmacol, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Jeonju 54907, South Korea 57196346934; 57223093866; 57223098219; 38260938400; 35216279300 houkiboshi01@knu.ac.kr;parkje6605@dgmif.re.kr;seoyo123@knu.ac.kr;mgkim@jbnu.ac.kr;kshin@knu.ac.kr; PHARMACEUTICS PHARMACEUTICS 1999-4923 13 4 SCIE PHARMACOLOGY & PHARMACY 2021 6.525 13.8 0.18 2025-07-30 2 2 DA-9701; prokinetic agents; natural product extracts; metabolomics; HRMS DA-9701; HRMS; Metabolomics; Natural product extracts; Prokinetic agents chlorogenic acid; corydaline; Corydalis yanhusuo root extract; da 9701; natural product; Pharbitis nil seed extract; plant extract; prokinetic agent; unclassified drug; adult; Article; chemical composition; controlled study; Corydalis yanhusuo; drug mechanism; gastrointestinal motility; human; human experiment; Ipomoea nil; lipid metabolism; metabolic fingerprinting; metabolite; normal human; pharmacometabolomics; purine metabolism; qualitative analysis; ultra performance liquid chromatography; urinalysis English 2021 2021-04 10.3390/pharmaceutics13040522 바로가기 바로가기 바로가기 바로가기
Article Naked-eye detection of Hg(II) ions by visible light-induced polymerization initiated by a Hg(II)-selective photoredox catalyst We developed a novel strategy for signal amplification using a visible light-induced photopolymerization, initiated by a selective turn-on photoredox catalyst. As photoredox catalysts, fluorescein derivatives are able to initiate photopolymerization and rapidly form a polymeric hydrogel in the presence of oxygen under visible light. Moreover, they exhibit selective chromogenic and fluorogenic responses to transition metal ions in the visible region of light. In this work, we employed fluorescein hydrazide as a switchable photoredox catalyst for the generation of a colorimetric readout of Hg(II) ions via the visible light-induced photopolymerization of N-vinylpyrrolidone and poly(ethylene glycol) diacrylate under aerobic conditions. Compared to ultraviolet-visible (UV-Vis) spectroscopy, this photopolymerization-based signal amplification yielded about 20 times higher sensitivity and enabled the naked-eye detection of Hg(II) ions with concentrations down to 0.1 mu M. Kim, Hyungwook; Jung, Young Jae; Lee, Jungkyu K. Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea 57211604325; 57211604984; 8312040000 jkl@knu.ac.kr; POLYMER CHEMISTRY POLYM CHEM-UK 1759-9954 1759-9962 12 7 SCIE POLYMER SCIENCE 2021 5.364 13.9 0.58 2025-07-30 8 8 DRIVEN; FLUORESCENT; SYSTEMS Catalysts; Eye protection; Light; Metal ions; Photopolymerization; Polyethylene glycols; Signal processing; Transition metal compounds; Transition metals; Aerobic condition; N vinylpyrrolidone; Naked-eye detection; Novel strategies; Polyethylene glycol diacrylate; Polymeric hydrogels; Signal amplifications; Visible light induced; Mercury compounds English 2021 2021-02-21 10.1039/d0py01616k 바로가기 바로가기 바로가기 바로가기
Article The effect of diet, exercise, and lifestyle intervention on childhood obesity: A network meta-analysis Background & aims: Trials investigating the efficacy of different interventions for overweight children are limited and controversial. Therefore, the aim of this study is to perform a network meta-analysis on the efficacy of various interventions for children with obesity (an average age of 6-12 years old). Methods: We obtained the data of trials reporting pre-post obesity relevant outcomes (e.g. BMI, BMI zscore, percent body fat, or percent overweight) from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid), PubMed, and Web of Science databases (completed before February 25, 2019) and included at least one pair of direct comparison groups. The mean difference of outcomes and their associated 95% CI were used to determine the efficacy. The P-score was calculated to illustrate the rank probability of various treatments for different outcomes using a network meta-analysis. Our metaanalysis included 24 studies that evaluated the interventions for childhood obesity. Results: All 24 trials had no high risk of bias. Interventions such as exercise without parents (E w/o P); diet with parents (D w/P); and diet, exercise, and lifestyle with parents (D+E+L w/P) were significantly effective for children with obesity when compared with no intervention. Conclusions: E w/o P exhibited the highest P-score, with the D w/P and D+E+L w/P ranks having P-scores of 0.7486 and 0.5464, respectively. Moreover, the results indicate that E w/o P, D w/P, and D+E+L w/P were significantly effective treatments for children with obesity when compared with no intervention. (c) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. Bae, Ji-Hyun; Lee, Hyorim Keimyung Univ, Food Sci & Nutr, Daegu, South Korea; Kyungpook Natl Univ, Home Econ Educ, Daegu, South Korea 8213707300; 57220022890 jhb@kmu.ac.kr;rimchild@knu.ac.kr; CLINICAL NUTRITION CLIN NUTR 0261-5614 1532-1983 40 5 SCIE NUTRITION & DIETETICS 2021 7.643 13.9 0.97 2025-07-30 18 17 Childhood obesity; Network meta-analysis; Diet; Exercise; Lifestyle intervention PREVENTION PROGRAMS; OVERWEIGHT; CHILDREN Childhood obesity; Diet; Exercise; Lifestyle intervention; Network meta-analysis Child; Diet; Exercise; Humans; Life Style; Pediatric Obesity; Article; body fat; body mass; child; childhood obesity; clinical effectiveness; dietary intake; exercise; human; intervention study; lifestyle; meta analysis; obesity; risk factor; treatment outcome; childhood obesity; diet; procedures English 2021 2021-05 10.1016/j.clnu.2020.11.006 바로가기 바로가기 바로가기 바로가기
Article Discharge transition experienced by older Korean women after hip fracture surgery: a qualitative study Background This study aimed to explore older Korean women's discharge transition experiences after hip fracture surgery. Methods This was a descriptive qualitative study. Face-to-face interviews following hip fracture surgery were conducted on 12 women aged 65-87 years. Data were collected 1 to 2 days before discharge and again 4 weeks after discharge following hip fracture surgery, and were analyzed using qualitative content analysis. Results Four main themes were identified: (1) challenge of discharge transition: unprepared discharge, transfer into other care settings, and eagerness for recovery; (2) physical and psychological distress against recovery: frail physical state and psychological difficulties; (3) dependent compliance: absolute trust in healthcare providers, indispensable support from the family, and passive participation in care; and (4) walking for things they took for granted: hope of walking and poor walking ability. Conclusions After their hip fracture surgeries, older women hoped to be able to walk and perform simple daily chores they previously took for granted. Considering the physical and psychological frailty of older women undergoing hip surgery, systematic nursing interventions including collaboration and coordination with other healthcare professionals and settings are necessary to ensure the quality of continuous care during their post-surgery discharge transition. Encouraging partial weight bearing and initiating intervention to reduce fear of falling at the earliest possible time are essential to attain a stable discharge transition. Additionally, older women should be invited to participate in their care, and family involvement should be encouraged during the discharge transition period in South Korea. Ko, Young Ji; Lee, Ju Hee; Baek, Seung-Hoon Daegu Haany Univ, Dept Nursing, Daegu, South Korea; Yonsei Univ, Coll Nursing, Seoul, South Korea; Kyungpook Natl Univ, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Daegu, South Korea 57209233650; 57190119637; 56232924900 yjko@dhu.ac.kr; BMC NURSING BMC NURS 1472-6955 20 1 SCIE;SSCI NURSING 2021 3.189 14.0 1.09 2025-07-30 8 9 Hip fracture; Qualitative research; Nursing; Frail elderly; Patient discharge; Phase transition FUNCTIONAL RECOVERY; PATIENTS PERCEPTION; CARE; MANAGEMENT; PEOPLE; FAMILY; REHABILITATION; SARCOPENIA; READINESS; SUPPORT Frail elderly; Hip fracture; Nursing; Patient discharge; Phase transition; Qualitative research English 2021 2021-06-28 10.1186/s12912-021-00637-9 바로가기 바로가기 바로가기 바로가기
Article Partly clustering solutions of nonlinear Schrodinger systems with mixed interactions In this paper, we prove a partly clustering phenomenon for nonlinear Schrodinger systems with large mixed couplings of attractive and repulsive forces, which arise from the models in Bose-Einstein condensates and nonlinear optics. More precisely, we consider a system with three components where the interaction between the first two components and the third component is repulsive, and the interaction between the first two components is attractive. Recent studies [10-13] in this case show that for large interaction forces, the first two components are localized in a region with a small energy and the third component is close to a solution of a single equation. Especially, the results in the works [12,13] say that the region of localization for a (locally) least energy vector solution on a ball in the class of radially symmetric functions is the origin or the whole boundary depending on the space dimension 1 <= n <= 3. In this paper we construct a new type of solutions with a region of localization different from the origin or the whole boundary. In fact, we show that there exist radially symmetric positive vector solutions with clustering multi-bumps for the first two components near the maximum point of r(n-1)U(3), where U is the limit of the third component and the maximum point is the only critical point different from the origin and the boundary. (C) 2021 Elsevier Inc. All rights reserved. Byeon, Jaeyoung; Lee, Youngae; Moon, Sang-Hyuck Korea Adv Inst Sci & Technol, Dept Math Sci, 291 Daehak Ro, Daejeon 34141, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Math Educ, Daegu, South Korea; Natl Taiwan Univ, Natl Ctr Theoret Sci, Taipei 106, Taiwan Lee, Youngae/GPG-2128-2022; Byeon, Jaeyoung/B-4528-2013 55801175700; 58239646700; 57208259387 byeon@kaist.ac.kr;youngaelee@knu.ac.kr;shmoon@ncts.ntu.edu.tw; JOURNAL OF FUNCTIONAL ANALYSIS J FUNCT ANAL 0022-1236 1096-0783 280 12 SCIE MATHEMATICS 2021 1.891 14.0 1.08 2025-07-30 6 6 Nonlinear Schrodinger systems; Mixed interactions; Multiple scaling LINEARLY COUPLED SYSTEMS; POSITIVE SOLUTIONS; BOUND-STATES; GROUND-STATES; PATTERN-FORMATION; STANDING WAVES; EQUATIONS; EXISTENCE; UNIQUENESS; SYMMETRY Mixed interactions; Multiple scaling; Nonlinear Schrödinger systems English 2021 2021-06-15 10.1016/j.jfa.2021.108987 바로가기 바로가기 바로가기 바로가기
Article Photoelectrochemical H2 evolution on WO3/BiVO4 enabled by single-crystalline TiO2 overlayer modulations Tungsten oxide/bismuth vanadate (WO3/BiVO4) has emerged as a promising photoanode material for photoelectrochemical (PEC) water splitting owing to its facilitated charge separation state differing significantly from single phase materials. Practical implementation of WO3/BiVO4 is often limited by poor stability arising from the leaching of V5+ from BiVO4 during PEC operations. Herein, we demonstrate that the synthesis of a tungsten oxide/bismuth vanadate/titanium oxide (WO3/BiVO4/TiO2) heterostructure onto a fluorine-doped tin oxide-coated glass substrate through a combined simple hydrothermal-spin coating strategy will advance PEC performance while slowing water oxidation kinetics and improving photostability. We show that surface postmodification with a nanometer-thick layer of (1 0 1) monofacet-selective single-crystalline TiO2 provides stable photocurrent density, up to 1.04 mA cm(-2) at 1.23 V (compared to a reversible hydrogen electrode in 0.5 M Na2SO4), with excellent quantum efficiency (45% at 460 nm) and long-term photostability (24 h). Interestingly, crystalline TiO2 activation layers behave differently from previous TiO2 amorphous layers, blocking surface defects while improving corrosion resistance, photostability, and the electron transfer process. These results indicate a approximate to 2.5 times enhancement in photoelectrocatalytic activity related to referenced WO3/BiVO4 photoanodes, encouraging the use of single-crystalline TiO2 modulations to develop a range of materials for PEC/photocatalytic applications. Park, Eunoak; Patil, Santosh S.; Lee, Hyeonkwon; Kumbhar, Vijay S.; Lee, Kiyoung Inha Univ, Dept Chem & Chem Engn, Incheon 22212, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, 80 Daehak Ro, Daegu, South Korea; Yamaguchi Univ, Grad Sch Sci & Technol Innovat, Appl Chem, Yamaguchi, Japan Lee, Kiyoung/J-8680-2013 57267047800; 57212424760; 57208133419; 55331146700; 57219211501 vijay1712phy@gmail.com;kiyoung@inha.ac.kr; NANOSCALE NANOSCALE 2040-3364 2040-3372 13 40 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED 2021 8.307 14.0 0.85 2025-07-30 25 24 HETEROJUNCTION PHOTOANODE; PHOTOCATALYTIC ACTIVITY; BISMUTH VANADATE; WATER OXIDATION; FABRICATION; MORPHOLOGY; ELECTRODEPOSITION; NANOSTRUCTURES; BIVO4 Bismuth compounds; Corrosion resistance; Hydrothermal synthesis; Modulation; Nanocomposites; Sodium sulfate; Spin glass; Substrates; Surface defects; Tin oxides; Titanium dioxide; Bismuth vanadates; Charge-separation; H 2 evolution; Overlayers; Photo-stability; Photoanode materials; Photoelectrochemical water splitting; Photoelectrochemicals; Single-crystalline; Single-phase materials; Tungsten compounds English 2021 2021-10-21 10.1039/d1nr04763a 바로가기 바로가기 바로가기 바로가기
Article Quantification of Upper Limb Isometric Force Control Abilities for Evaluating Upper Limb Functions Among Prosthetic Users Force control abilities are essential to interact with objects in our environments. However, there is a lack of evaluation tools and methods to test the force control abilities of the upper limb in evaluating the upper limb functions of prosthetic users. This study aimed to quantify upper limb isometric force control abilities in healthy individuals and prosthetic users using a custom-built handle with a 6-axis force/torque sensor and visual cue, namely an Upper Limb End-effector type Force control test device (ULEF). Feasibilities of the test device were demonstrated through experiments by holding the ULEF with an intact hand among healthy subjects and transradial and wrist amputees with a myoelectric powered prosthetic hand, the bebionic hand. Compared to the healthy individuals, the prosthetic user group demonstrated poor isometric force control abilities in terms of higher control instability during the lateral direction task (p<0.05). Significantly higher variability in force-generating rates was also found in all task directions in the prosthetic user group (p<0.05). Compared to the healthy group, the prosthetic user group showed significant small peak biceps activities during the posterior task (p<0.05) and anterior task (p<0.05). Quantification of isometric upper limb force control abilities can potentially be beneficial to develop evaluation and research tools for investigating mechanisms underlying force control abilities of prosthetic users and provide guidelines for targeted isometric force control training and prosthesis development. Lee, Jae Hyung; Oh, Ye Eun; Lee, Hyun Joo; Kim, Keehoon; Lee, Song Joo Korea Inst Sci & Technol, Seoul 02792, South Korea; Ctr Human Ctr Interact Coexistence, Seoul 02792, South Korea; Kyungbook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, Daegu 41944, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Mech Engn, Pohang 37673, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Bion, Seoul 02792, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea 57209644220; 57203662623; 58838750100; 59475350100; 58632737600 songjoolee@kist.re.kr; IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING IEEE T NEUR SYS REH 1534-4320 1558-0210 29 SCIE ENGINEERING, BIOMEDICAL;REHABILITATION 2021 4.528 14.0 0.5 2025-07-30 3 6 Prosthetic users; force control abilities; upper limb function I-LIMB; HAND; DESIGN force control abilities; Prosthetic users; upper limb function Amputees; Artificial Limbs; Hand; Humans; Upper Extremity; Wrist Joint; Artificial limbs; Function evaluation; Job analysis; Force; Force control ability; Isometric force; Prosthetic hands; Prosthetic user; Task analysis; Upper limbs; Upper-limb function; User groups; Wrist; activity of daily living assessment; Article; biceps brachii muscle; clinical article; control system; controlled study; feasibility study; flexion contracture; force; hand movement; human; isometric exercise; joint instability; muscle contraction; normal human; overall response rate; peripheral nervous system; quantitative analysis; torque; upper limb; amputee; hand; limb prosthesis; upper limb; wrist; Force control English 2021 2021 10.1109/tnsre.2021.3133539 바로가기 바로가기 바로가기 바로가기
Article Topographically designed hybrid nanostructures via nanotransfer printing and block copolymer self-assembly Nanotransfer printing (nTP) has attracted much attention due to its high pattern resolution, simple process, and low processing cost for useful nanofabrication. Here, we introduce a thermally assisted nTP (T-nTP) process for the effective fabrication of various periodic three-dimensional (3D) nanosheets, such as concavo-convex lines, spine lines, square domes, and complex multi-line patterns. The T-nTP method allows continuous nanoscale 3D patterns with functionality to be transferred onto both rigid and flexible substrates by heat without any collapse of uniform convex nanostructures with nanochannels. We also show the pattern formation of multi-layered hybrid structures consisting of two or more materials by T-nTP. Furthermore, the formation of silicon oxide nanodots (0D) within a printed metallic nanowave structure (3D) can be achieved by the combined method of T-nTP and the self-assembly of poly(styrene-b-dimethylsiloxane) (PS-b-PDMS) block copolymers. Moreover, we demonstrate how to obtain well-defined oxide-metal hybrid nanostructures (0D-in-3D) through the spontaneous accommodation of PDMS spheres in the confined spaces of an Au-wave nanotemplate. This approach is applicable during the nanofabrication of various high-resolution devices with complex geometrical nanopatterns. Park, Tae Wan; Jung, Hyunsung; Park, Jinyoung; Ahn, Yong-Sik; Hong, Suck Won; Lee, Junghoon; Lee, Jong-Heun; Park, Woon Ik Korea Inst Ceram Engn & Technol KICET, Elect Convergence Mat Div, 101 Soho Ro, Jinju 52851, South Korea; Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Pukyoung Natl Univ PKNU, Dept Mat Sci & Engn, 45 Yongso Ro, Busan 48513, South Korea; Pusan Natl Univ, Dept Opt & Mechatron Engn, Dept Cognomechatron Engn, Coll Nanosci & Nanotechnol, Busan 46241, South Korea; Pukyoung Natl Univ PKNU, Dept Met Engn, 45 Yongso Ro, Busan 48513, South Korea Ahn, Yong-Sik/F-5192-2016; PARK, JUN-YOUNG/P-5981-2015; Park, Woon/C-4583-2011; Lee, Jong-Heun/E-3923-2012 57189896587; 36169909800; 57286293400; 8589965400; 57252820400; 56100706800; 26643283000; 53980463200 jongheun@korea.ac.kr;thane0428@pknu.ac.kr; NANOSCALE NANOSCALE 2040-3364 2040-3372 13 25 SCIE CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED 2021 8.307 14.0 0.34 2025-07-30 7 6 LITHOGRAPHY; FABRICATION; PATTERNS Hybrid materials; Microchannels; Nanostructures; Self assembly; Silicon compounds; Silicon oxides; Styrene; Block copolymer self-assembly; Hybrid nanostructures; Nanotransfer printing; Nanotransfer printing (nTP); Pattern resolution; Poly(styrene-b-dimethylsiloxane); Rigid and flexible substrates; Threedimensional (3-d); Block copolymers English 2021 2021-07-07 10.1039/d1nr02358f 바로가기 바로가기 바로가기 바로가기
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