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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Meeting Abstract ⓘ Investigating the Roles of Orexinergic System in Methamphetamine-induced Addiction ⓘ ⓘ Lee, Chan; Bae, Hui; Jang, Jung-Hee; Park, Gyu ⓘ Keimyung Univ, Daegu, South Korea; Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.09577 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ MAP kinases-Regulated Proteins in Downstream Signaling Pathways of Vasopressin V2 Receptor in Kidney Collecting Duct ⓘ ⓘ Jang, Hyo-Ju; Jung, Hyun; Choi, Hyo-Jung; Park, Eui-Jung; Park, Hye-Jeong; Kwon, Tae-Hwan ⓘ Kyungpook Natl Univ, Sch Med, Daegu, South Korea ⓘ Park, Hye/C-1648-2013 ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.03844 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Nrf2-Activating Phytochemicals, Sulforaphane and Licochalcone A, Stimulate Cell Growth-Regulating Kinases in HCT116 Human Colorectal Cancer Cells ⓘ ⓘ Jang, Chan; Oh, Jisun; Kim, Jong-Sang ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol BK21PLUS, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 2 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.05106 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Role of ppGpp-regulated efflux genes in Acinetobacter baumannii ⓘ Objectives: Treatment of infections caused by Acinetobacter baumannii nosocomial strains has become increasingly problematic owing to their resistance to antibiotics. ppGpp is a secondary messenger involved in growth control and various stress responses in bacteria. The mechanism for inhibition of antibiotic resistance via ppGpp is still unidentified in various pathogenic bacteria including A. baumannii. Here, we investigated the effects of ppGpp on efflux pump (EP)-related genes in A. baumannii. Methods: ppGpp-deficient and -complementary strains were constructed by conjugation and we confirmed (p)ppGpp measurements by thin-layer chromatography. We observed that the ppGpp-deficient strain (Delta A1S₀₅₇₉) showed abnormal stretching patterns by transmission electron microscopy analysis. The MICs of antimicrobial agents for the WT A. baumannii (ATCC 17978), ppGpp-deficient and complementary strains were determined by the Etest and broth dilution assay methods. The expression levels of EP-related genes were determined by quantitative RT-PCR. Results: We observed morphological differences between a ppGpp-deficient strain (Delta A1S₀₅₇₉) and the WT strain. Dramatic reductions of MICs in the ppGpp-deficient strain compared with the WT were observed for gentamicin (2.6-fold), tetracycline (3.9-fold), erythromycin (4-fold) and trimethoprim (>4-fold). Expression of the EP-related genes abeB (2.8-fold), tet(A) (2.3-fold), adeB (10.0-fold), adeI (9.9-fold), adeJ (11.8-fold) and adeK (14.4-fold) was also decreased in the ppGpp-deficient strain. Conclusions: This study demonstrates that ppGpp regulates EP-related gene expression in A. baumannii, affecting antibiotic susceptibility. To date, treatment for MDR A. baumannii has had no new antimicrobial agents, so the A1S₀₅₇₉ gene could be a novel therapeutic target for rational drug design by affecting ppGpp production. ⓘ Jung, Hye-Won; Kim, Kyeongmin; Islam, M. Maidul; Lee, Je Chul; Shin, Minsang ⓘ Kyungpook Natl Univ, Dept Microbiol, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea ⓘ Islam, Md. Maidul/AAX-1696-2021 ⓘ 57216604654; 57216604095; 57216605059; 25930392000; 7401536650 ⓘ shinms@knu.ac.kr; ⓘ JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY ⓘ J ANTIMICROB CHEMOTH ⓘ 0305-7453 1460-2091 75 5 SCIE INFECTIOUS DISEASES;MICROBIOLOGY;PHARMACOLOGY & PHARMACY ⓘ 2020 5.79 14.5 1.64 2025-06-25 ⓘ 28 28 ⓘ CELL-DIVISION; (P)PPGPP; RESISTANCE; PHYSIOLOGY ⓘ ⓘ Acinetobacter baumannii; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Guanosine Tetraphosphate; Membrane Transport Proteins; Microbial Sensitivity Tests; aztreonam; cefotaxime; cefoxitin; ceftazidime; chloramphenicol; ciprofloxacin; colistin; erythromycin; gentamicin; imipenem; levofloxacin; meropenem; nalidixic acid; tetracycline; trimethoprim; tigecycline; antiinfective agent; bacterial protein; carrier protein; guanosine 3' diphosphate 5' diphosphate; abeB gene; Acinetobacter baumannii; adeB gene; adeI gene; adeJ gene; adeK gene; antibiotic resistance; antibiotic sensitivity; Article; bacterial gene; bacterial mutation; bacterial strain; bacterium conjugation; bacterium culture; broth dilution; controlled study; epsilometer test; gene control; gene expression level; gene function; gene mutation; Gram staining; minimum inhibitory concentration; morphological trait; nonhuman; ppGpp gene; real time polymerase chain reaction; tetA gene; thin layer chromatography; transmission electron microscopy; antibiotic sensitivity; gene deletion; gene expression; phenotype; polymerase chain reaction; trimethoprim resistance; genetics; metabolism; microbial sensitivity test; multidrug resistance ⓘ English 2020 2020-05 10.1093/jac/dkaa014 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Screening assay using an epigenetic modulator library identifies I10 that promotes melanin synthesis in B16/F10 melanoma cells ⓘ ⓘ Hwang, Yun; Boo, Yong ⓘ Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.09957 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling ⓘ Background: As the number of allergic disease increases, studies to identify new treatments take on new urgency. Epigallocatechin gallate (EGCG), a major component of green tea, has been shown to possess a wide range of pharmacological properties, including anti-inflammation and anti-viral infection. In previous study, gallic acid (GA), a part of EGCG, has shown anti-allergic inflammatory effect. To improve on preliminary evidence that GA has allergy mitigating effect, we designed SG-SP1 based on GA, and aimed to assess the effects of SG-SP1 on mast cell-mediated allergic inflammation using various animal and in vitro models. Methods: For in vitro experiments, various types of IgE-stimulated mast cells (RBL-2H3: mast cell-like basophilic leukemia cells, and primary cultured peritoneal and bone marrow-derived mast cells) were used to determine the role of SG-SP1 (0.1-1 nM). Immunoglobulin (Ig) E-induced passive cutaneous anaphylaxis and ovalbumin-induced systemic anaphylaxis, standard animal models for immediate-type hypersensitivity were also used. Results: For in vitro, SG-SP1 reduced degranulation of mast cells by down-regulating intracellular calcium levels in a concentration-dependent manner. SG-SP1 decreased expression and secretion of inflammatory cytokines in activated mast cells. This suppressive effect was associated with inhibition of the phosphorylation of Lyn, Syk and Akt, and the nuclear translocation of nuclear factor-kappa B. Due to the strong inhibitory effect of SG-SP1 on Lyn, the known upstream signaling to Fc epsilon RI-dependent pathway, we confirmed the direct binding of SG-SP1 to Fc epsilon RI, a high affinity IgE receptor by surface plasmon resonance experiment. Oral administration of SG-SP1 hindered allergic symptoms of both anaphylaxis models evidenced by reduction of hypothermia, serum IgE, ear thickness, and tissue pigmentation. This inhibition was mediated by the reductions in serum histamine and interleukin-4. Conclusions: We determined that SG-SP1 directly interacts with Fc epsilon RI and propose SG-SP1 as a therapeutic candidate for mast cell-mediated allergic inflammatory disorders via inhibition of Fc epsilon RI signaling. ⓘ Kim, Min-Jong; Je, In-Gyu; Song, Jaeyoung; Fei, Xiang; Lee, Soyoung; Yang, Huiseon; Kang, Wonku; Jang, Yong Hyun; Seo, Seung-Yong; Kim, Sang-Hyun ⓘ Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu, South Korea; ILDONG Pharmaceut Co Ltd, Res Labs, Hwaseong, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea; Gachon Univ, Coll Pharm, Incheon, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea ⓘ Fei, Xiang/Z-1378-2019; Fei, Xiang/D-6670-2014 ⓘ 57192888932; 56009260600; 56184911300; 56091158600; 8537269200; 57214937777; 7202401591; 57016046400; 7202469894; 57210450420 ⓘ yhjang@knu.ac.kr;syseo@gachon.ac.kr;shkim72@knu.ac.kr; ⓘ FRONTIERS IN IMMUNOLOGY ⓘ FRONT IMMUNOL ⓘ 1664-3224 11 SCIE IMMUNOLOGY ⓘ 2020 7.561 14.5 0.68 2025-06-25 ⓘ 17 18 SG-SP1; gallic acid; mast cells; allergic inflammation; Fc epsilon RI ⓘ NF-KAPPA-B; HISTAMINE-RELEASE; ASTHMA; ANAPHYLAXIS; CALCIUM; MICE; IMMUNOTHERAPY; MANAGEMENT; EFFECTOR; ANTIGEN ⓘ allergic inflammation; FcεRI; gallic acid; mast cells; SG-SP1 ⓘ Anaphylaxis; Animals; Anti-Inflammatory Agents; Calcium; Calcium Signaling; Cell Degranulation; Cell Survival; Cells, Cultured; Gallic Acid; Immunoglobulin E; Inflammation; Male; Mast Cells; Mice; Mice, Inbred ICR; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Sprague-Dawley; Receptors, IgE; antiallergic agent; antiinflammatory agent; fc epsilon receptor i; Fc receptor; gallic acid; histamine; immunoglobulin E; immunoglobulin E receptor; immunoglobulin enhancer binding protein; interleukin 4; ovalbumin; protein kinase B; protein kinase Lyn; protein kinase Syk; sg sp1; unclassified drug; antiinflammatory agent; calcium; gallic acid; immunoglobulin E; immunoglobulin E receptor; ovalbumin; animal cell; animal experiment; Article; bone marrow derived mast cell; calcium cell level; concentration response; cytokine release; down regulation; drug design; drug mechanism; ear thickness; female; histamine blood level; hypothermia; immediate type hypersensitivity; in vitro study; male; mast cell; mast cell degranulation; nonhuman; passive skin anaphylaxis; peritoneum mast cell; primary culture; protein phosphorylation; rat; RBL-2H3 cell line; signal transduction; surface plasmon resonance; systemic anaphylaxis; anaphylaxis; animal; calcium signaling; cell culture; cell survival; degranulation; drug effect; immunology; inflammation; Institute for Cancer Research mouse; mast cell; metabolism; mouse; Sprague Dawley rat ⓘ English 2020 2020-01-28 10.3389/fimmu.2020.00050 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ TGFBI inhibits endothelial angiogenesis stimulated by adopocyte conditioned medium ⓘ ⓘ Lee, Seul; Nam, Ju-Ock ⓘ Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.08957 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ The Efficacy of Ultrasonic Bone Scalpel for Unilateral Cervical Open-Door Laminoplasty: A Randomized Controlled Trial ⓘ BACKGROUND: In cervical open-door laminoplasty for cervical myelopathy, a high-speed rotatory drill and rongeurs are used to make unicortical troughs and bicortical openings in the laminae. The lamina is reflected at the trough to enlarge the spinal canal, followed by bone healing on the hinge side to stabilize laminoplasty. The ultrasonic bone scalpel (UBS) has been used due to theoretical advantages including a better hinge union rate, less soft tissue trauma, less neurological injury, and shorter operative time. OBJECTIVE: To assess the superiority of UBS for hinge union compared to the drill through randomized controlled trial. METHODS: In 190 randomly allocated cervical myelopathy patients, the trough and opening at the lamina were made using either the drill (n = 95) or UBS (n = 95) during 2015 to 2018. The primary outcome was the hinge union rate on 6-mo postoperative computed tomography. Secondary outcomes included the hinge union rate at 12 mo, the operative time, intraoperative/postoperative bleeding, neurological injury, complications, and clinical outcomes over a 24-mo follow-up. RESULTS: Hinge union in all laminae was achieved in 60.0% (drill) and 43.9% (UBS) of patients at 6 mo (intention-to-treat analysis; P = .02; odds ratio, 2.1) and in 91.9% (drill) and 86.5% (UBS) at 12 mo. Dural injury only occurred in the drill group (2.1%), and the UBS group showed significantly less intraoperative bleeding (P < .01). The other secondary outcomes did not differ between groups. CONCLUSION: The hinge union rate was inferior in the UBS group at 6 mo postoperatively, but UBS was efficacious in reducing dural injuries and bleeding. ⓘ Kim, Chi Heon; Chung, Chun Kee; Choi, Yunhee; Kuo, Calvin C.; Lee, Urim; Yang, Seung Heon; Lee, Chang-Hyun; Jung, Jong-Myung; Hwang, Sung Hwan; Kim, Dong Hwan; Yoon, Joon Ho; Paik, Seoi; Lee, Hwa Jin; Jung, Sunhyang; Park, Sung; Kim, Kyoung-Tae; Park, Hee-Pyoung ⓘ Seoul Natl Univ Hosp, Dept Neurosurg, Seoul, South Korea; Seoul Natl Univ, Dept Neurosurg, Coll Med, 101 Daehak Ro, Seoul 110744, South Korea; Seoul Natl Univ Hosp, Dept Brain & Cognit Sci, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurosurg, Human Brain Funct Lab, Seoul, South Korea; Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Div Med Stat, Seoul, South Korea; Kaiser Permanente, Reg Spine Surg Dept, Oakland, CA USA; Seoul Natl Univ, Dept Neurosurg, Bundang Hosp, Kyung Gi, South Korea; Seoul Natl Univ Hosp, Dept Nursing, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Neurosurg, Boramae Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Anesthesiol & Pain Med, Seoul, South Korea; Seoul Natl Univ, Dept Anesthesiol & Pain Med, Coll Med, Seoul, South Korea ⓘ Choi, You-Jung/AFR-4193-2022; Kim, Chi/J-6536-2019; Chung, Chun/J-5650-2012; Paik, Soonmyung/LZH-8806-2025; Park, Hee/J-5500-2012; Lee, Chang-Hoon/AAC-7650-2021 ⓘ 35145892000; 7403613043; 7404777879; 7404480701; 57202114795; 56440402100; 56942572100; 55261473000; 57202116893; 58839372700; 57208619680; 59573493700; 57216890190; 57216890540; 45261436700; 57201369790; 15758312400 ⓘ chungc@snu.ac.kr; ⓘ NEUROSURGERY ⓘ NEUROSURGERY ⓘ 0148-396X 1524-4040 86 6 SCIE CLINICAL NEUROLOGY;SURGERY ⓘ 2020 4.654 14.5 1.04 2025-06-25 ⓘ 19 20 Cervical vertebra; Laminoplasty; Laminectomy; Spinal cord compression; Spinal fusion; Surgery; Ultrasonic osteotome ⓘ HEAT-GENERATION; HINGE FRACTURE; IN-VITRO; SURGERY; IRRIGATION; CLOSURE; CURETTE; DEVICE; RISK; PIEZOSURGERY ⓘ Cervical vertebra; Laminectomy; Laminoplasty; Spinal cord compression; Spinal fusion; Surgery; Ultrasonic osteotome ⓘ Adult; Aged; Cervical Vertebrae; Female; Humans; Laminoplasty; Male; Middle Aged; Retrospective Studies; Spinal Cord Diseases; Tomography, X-Ray Computed; Treatment Outcome; Ultrasonic Therapy; adult; Article; brain injury; cervical myelopathy; cervical open door laminoplasty; clinical outcome; computer assisted tomography; controlled study; European Quality of Life 5 Dimensions questionnaire; female; human; Japanese Orthopaedic Association score; laminoplasty; major clinical study; male; middle aged; Neck Disability Index; open surgery; operation duration; outcome assessment; postoperative care; postoperative hemorrhage; priority journal; randomized controlled trial; surgical technique; aged; cervical vertebra; devices; diagnostic imaging; laminoplasty; procedures; retrospective study; spinal cord disease; treatment outcome; ultrasound therapy; x-ray computed tomography ⓘ English 2020 2020-06 10.1093/neuros/nyz301 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Novel Tyrosine Kinase Inhibitor Can Augment Radioactive Iodine Uptake Through Endogenous Sodium/Iodide Symporter Expression in Anaplastic Thyroid Cancer ⓘ Background: Radioactive iodine (RAI) therapy is an important strategy in the treatment of thyroid cancer. However, anaplastic thyroid cancer (ATC), a rare malignancy, exhibits severe dedifferentiation characteristics along with a lack of sodium iodide symporter (NIS) expression and function. Therefore, RAI therapy is ineffective and contributes toward poor prognosis of these patients. Recently, small-molecule tyrosine kinase inhibitors (TKIs) have been used to treat thyroid cancer patients for restoring NIS expression and function and RAI uptake capacity. However, most results reported thus far are associated with differentiated thyroid cancer. In this study, we identified a new TKI and investigated its effects on cell redifferentiation, NIS function, and RAI therapy in ATC. Methods: We identified a new TKI, "5-(5-{4H, 5H,6H-cyclopenta[b]thiophen-2-yl}-1,3,4-oxadiazol-2-yl)-1-methyl-1,2-dihydropyridin-2-one" (CTOM-DHP), using a high-throughput screening system. CTOM-DHP was exposed to 8505C ATC cells at different concentrations and time points. Concentrations of 12.5 and 25 mu M and an incubation time of 72 hours were chosen as the conditions for subsequent NIS promoter assays and NIS mRNA and protein expression experiments. In addition, we examined factors related to iodide metabolism after CTOM-DHP treatment as well as the signaling pathways mediating the effects of CTOM-DHP on endogenous NIS expression. RAI uptake and I-131 cytotoxicity effects caused by CTOM-DHP pretreatment were also evaluated in vitro and in vivo. Results: Promoter assays as well as mRNA and protein expression analyses confirmed that NIS expression was augmented by treatment of 8505C ATC cells with CTOM-DHP. Moreover, CTOM-DHP treatment robustly increased the expression of other thyroid-specific proteins and thyroid transcription factors related to iodide metabolism. Enhancement of NIS function was demonstrated by an increase in I-125 uptake and I-131 cytotoxicity. Increased endogenous NIS expression was associated with the inhibition of PI3K/Akt and MAPK signaling pathways. In vivo results also demonstrated an increase in NIS promoter activity and RAI avidity in response to CTOM-DHP treatment. Furthermore, I-131-mediated therapeutic effects preferentially improved in a tumor xenograft mice model. Conclusions: CTOM-DHP, a new TKI identified in this study, enhances endogenous NIS expression and thereby is a promising compound for restoring RAI avidity in ATC. ⓘ Oh, Ji Min; Baek, Se Hwan; Gangadaran, Prakash; Hong, Chae Moon; Rajendran, Ramya Lakshmi; Lee, Ho Won; Zhu, Liya; Gopal, Arunnehru; Kalimuthu, Senthilkumar; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol ⓘ Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Gukchaebosang Ro 680, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea ⓘ ; Lee, Jaetae/ABF-3980-2020; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021; lee, sangwoo/KUD-1906-2024 ⓘ 57190370462; 57194785139; 54393130400; 37050876700; 57195318729; 35337240700; 57190870383; 57203278478; 54794141400; 36164032500; 57196249819; 7601451907; 7202791511 ⓘ abc2000@knu.ac.kr; ⓘ THYROID ⓘ THYROID ⓘ 1050-7256 1557-9077 30 4 SCIE ENDOCRINOLOGY & METABOLISM ⓘ 2020 6.568 14.7 1.67 2025-06-25 ⓘ 22 23 anaplastic thyroid cancer; sodium iodide symporter; tyrosine kinase inhibitor; radioactive iodine therapy; cytotoxicity ⓘ RADIOIODINE UPTAKE; TSH RECEPTOR; GENE; CARCINOMA; THERAPY; BRAF; REDIFFERENTIATION; PEROXIDASE; TUMORS; PAX-8 ⓘ anaplastic thyroid cancer; cytotoxicity; radioactive iodine therapy; sodium iodide symporter; tyrosine kinase inhibitor ⓘ Cell Line, Tumor; Cell Survival; Humans; Iodine Radioisotopes; Protein Kinase Inhibitors; Symporters; Thyroid Carcinoma, Anaplastic; Thyroid Gland; Thyroid Neoplasms; 5 [5 [4h, 5h,6h cyclopenta[b]thiophen 2 yl] 1,3,4 oxadiazol 2 yl) 1 methyl 1,2 dihydropyridin 2 one; histone H2AX; iodine 125; messenger RNA; mitogen activated protein kinase; phosphatidylinositol 3 kinase; protein kinase B; protein tyrosine kinase inhibitor; sodium iodide i 131; sodium iodide symporter; unclassified drug; cotransporter; protein kinase inhibitor; radioactive iodine; sodium iodide symporter; 8505C cell line; anaplastic thyroid carcinoma; animal experiment; animal model; animal tissue; Article; autoradiography; bioluminescence; cancer combination chemotherapy; cancer tissue; cell differentiation; cell viability; controlled study; cytotoxicity; DNA damage; enhancer region; female; high throughput screening; immunofluorescence; immunofluorescence microscopy; immunohistochemistry; in vitro study; in vivo study; mouse; mouse model; nonhuman; priority journal; promoter region; protein expression; quantitative analysis; real time reverse transcription polymerase chain reaction; signal transduction; tumor volume; tumor xenograft; Western blotting; cell survival; drug effect; human; metabolism; pathology; thyroid carcinoma; thyroid gland; thyroid tumor; tumor cell line ⓘ English 2020 2020-04-01 10.1089/thy.2018.0626 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Aberrant electronic and structural alterations in pressure tuned perovskite NaOsO3 ⓘ The perovskite NaOsO3 has a metal-insulator transition at temperature 410 K, which is delicate, intriguing, and provokes a lot of debate on its nature. Our combined electrical resistance, Raman, and synchrotron x-ray diffraction experiments show that the insulating ground state in this osmate endures under high pressure up to at least 35 GPa. In this pressure range, compression reveals hidden hysteretic resistance properties with a transient metallic state near 200 K, manifested three electronic character anomalies (at 1.7, 9.0, and 25.5 GPa), and a structural transition to the singular polar phase (at similar to 18 GPa). We distinguish NaOsO3 from the regular crystallographic behavior of perovskites, though the electrical specificities resemble iridates and nickelates. The theoretical first-principle band structure and lattice dynamics calculations demonstrate that the magnetically itinerant Lifshitz-type mechanism with spin-orbit and spin-phonon interactions is responsible for these pressure-induced changes. Our findings provide another new playground for the emergence of new states in 5dmaterials by using high-pressure methods. ⓘ Sereika, Raimundas; Liu, Peitao; Kim, Bongjae; Kim, Sooran; Zhang, Jianbo; Chen, Bijuan; Yamaura, Kazunari; Park, Changyong; Franchini, Cesare; Ding, Yang; Mao, Ho-kwang ⓘ Ctr High Pressure Sci & Technol Adv Res, Beijing 100094, Peoples R China; Vytautas Magnus Univ, K Donelaicio 58, LT-44248 Kaunas, Lithuania; Univ Vienna, Fac Phys, Sensengasse 8, A-1090 Vienna, Austria; Univ Vienna, Ctr Computat Mat Sci, Sensengasse 8, A-1090 Vienna, Austria; Kunsan Natl Univ, Dept Phys, Gunsan 54150, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea; Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan; Argonne Natl Lab, Xray Sci Div, HPCAT, Lemont, IL 60439 USA; Univ Bologna, Dipartimento Fis & Astron, I-40127 Bologna, Italy ⓘ Zhang, Jianbo/AAW-4090-2021; YAMAURA, Kazunari/AEW-0565-2022; Franchini, Cesare/B-2084-2009; Sereika, Raimundas/AAA-6235-2019; Liu, Peitao/AAA-9994-2019; YAMAURA, KAZUNARI/AEW-0565-2022; Park, Changyong/A-8544-2008 ⓘ 21740323500; 55917639400; 55650566000; 55146733200; 54899092600; 56182281000; 7004349948; 55728013600; 7004508444; 36107702600; 57203333869 ⓘ raimundas.sereika@hpstar.ac.cn;cesare.franchini@univie.ac.at;yang.ding@hpstar.ac.cn; ⓘ NPJ QUANTUM MATERIALS ⓘ NPJ QUANTUM MATER ⓘ 2397-4648 5 1 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER;QUANTUM SCIENCE & TECHNOLOGY ⓘ 2020 7.032 14.7 0.33 2025-06-25 ⓘ 7 7 ⓘ PHASE-TRANSITION; PROGRAM; OXIDES ⓘ ⓘ ⓘ English 2020 2020-09-16 10.1038/s41535-020-00269-3 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Aspergillus nigerboosted heat stress tolerance in sunflower and soybean via regulating their metabolic and antioxidant system ⓘ Plants can be severely affected by heat stress due to rapid environmental changes. Use of endophytic fungi is a new tool to protect crops from the environmental stresses. Here we claim a potent endophyte isolated fromSonchus asperL. The aim was to explore the stress adaptive mechanism of sunflower and soybean mediated byAspergillus niger(SonchL-7) under high temperature. Inoculation withA. nigerboosted plant height, biomass and chlorophyl contents, while significantly curtailed the concentration of lipid peroxidation and reactive oxygen species (ROS) under thermal stress at 40 degrees C. Moreover, the ROS-scavenging activities, like ascorbic acid oxidase (AAO), catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD) and peroxidase (POD) were augmented. Also, proline and phenolics were enhanced in the tested crops, while ABA concentration was significantly reduced. These positive results suggested thatA. nigercan be used as a heat-stress ameliorative tool for crops in the future. ⓘ Ismail; Hamayun, Muhammad; Hussain, Anwar; Iqbal, Amjad; Khan, Sumera Afzal; Lee, In-Jung ⓘ Abdul Wali Khan Univ Mardan, Dept Bot, Mardan 23200, Pakistan; Abdul Wali Khan Univ Mardan, Dept Food Sci & Technol, Mardan, Pakistan; Univ Peshawar, Ctr Biotechnol & Microbiol, Mardan, Pakistan; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea ⓘ Iqbal, Amjad/E-2010-2014; Hamayun, Muhammad/B-1694-2010; Hussain, Anwar/N-1605-2019; Khan, Abdul/H-5910-2011; Lee, In-Jung/GLS-0432-2022 ⓘ 57205183198; 59297330100; 35621772200; 10142205100; 9636646900; 16425830900 ⓘ hamayun@awkum.edu.pk;ijlee@knu.ac.kr; ⓘ JOURNAL OF PLANT INTERACTIONS ⓘ J PLANT INTERACT ⓘ 1742-9145 1742-9153 15 1 SCIE PLANT SCIENCES ⓘ 2020 4.208 14.7 3 2025-06-25 ⓘ 27 50 Climate change; endophytic fungi; Aspergillus Niger; Sonchus asperL; antioxidants; thermal stress ⓘ RAPID-DETERMINATION; SALINITY TOLERANCE; PLANT-GROWTH; ACID; PROLINE; ARABIDOPSIS; ACCUMULATION; GIBBERELLINS; CATALASE; ROLES ⓘ antioxidants; Aspergillus Niger; Climate change; endophytic fungi; Sonchus asper L; thermal stress ⓘ ⓘ English 2020 2020-01-01 10.1080/17429145.2020.1771444 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Clinical outcomes and response predictors of vedolizumab treatment for anti-TNF-failed patients with IBD in Korea: A prospective multicenter cohort study ⓘ ⓘ Kim, J.; Yoon, H.; Lee, K. M.; Jung, S. A.; Park, D. I.; Choi, C. H.; Kim, E. S.; Jung, Y.; Eun, C. S.; Kim, T. O.; Kang, S. B.; Kim, Y. S.; Seo, G. S.; Lee, C. K.; Im, J. P.; Park, S. J.; Byeon, J. S.; Myung, S. J.; Yang, S. K.; Ye, B. D. ⓘ Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Internal Med, Suwon, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Gastroenterol,Sch Med, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Soonchunhyang Univ, Coll Med, Dept Med, Div Gastroenterol, Cheonan, South Korea; Hanyang Univ, Guri Hosp, Dept Internal Med, Guri, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Daejeon, South Korea; Inje Univ, Coll Med, Seoul Paik Hosp, Dept Internal Med, Seoul, South Korea; Wonkwang Univ, Sch Med, Dept Internal Med, Iksan, South Korea; Kyung Hee Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Severance Hosp, Seoul, South Korea ⓘ Kim, Joo/JAZ-0897-2023; Myung, Sun-Jung/J-5464-2012; Kim, Jung Oh/JDC-5061-2023; Kwak, Sang Gyu/AAG-4341-2021; Lee, Chang/AAI-1012-2020; Ye, Byong/AAF-4955-2020; Kim, Eun-young/AAI-8613-2020; Yoon, Hyuk/AAT-4978-2020 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 14 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2020 9.071 14.7 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-01 ⓘ 바로가기 바로가기
○ ○ Article ⓘ Development of a Squaraine-Based Molecular Probe for Dual-Modal in Vivo Fluorescence and Photoacoustic Imaging ⓘ Dual-modular imaging approaches combining near-infrared (NIR) fluorescence (FLI) and photoacoustic imaging (PAI) require suitable contrast agents to produce dual-modular signals. Although nanoparticles have been used to develop PAI agents, small molecule-based imaging agents have not been extensively studied, highlighting the need to design new fluorophores with an enhanced multifunctional ability. Thus, in this study, we designed a novel squaraine (SQ)-based dye and reported its rational preparation and conjugation with a cancer targeting peptide. Specifically, benzoindole-derived SQ (BSQ) showed strong absorption and fluorescence properties at above 650 nm under aqueous conditions, with a maximum absorption and emission at 665 and 680 nm, respectively. Moreover, PA signal scanning experiments revealed a maximum signal intensity in the range 680-700 nm. BSQ was also conjugated with cyclic arginine-glycine-aspartic acid (cRGD) to improve its active targeting ability for the alpha(v)beta(3) integrin, which is overexpressed in various cancer and angiogenic cells. A series of in vitro, in vivo, and ex vivo FLI studies showed that the cRGD conjugated BSQ (BSQ-RGD(2)) successfully stained and targeted alpha(v)beta(3) integrin-overexpressing tumor cells and xenografts, which were clearly visualized by FLI and PAI. Therefore, BSQ-RGD(2) can successfully be applied to dual-modular imaging of the specific biomarker in living animals. ⓘ Park, Yong Dae; Park, Jam-Eon; Kim, Hyeon Sik; Choi, Seung-Hyeon; Park, Jung Eun; Jeon, Jongho; Park, Seung-Hwan ⓘ Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 56212, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr, Jeongeup 56212, South Korea; Korea Photon Technol Inst, Med Photon Res Ctr, Gwang Ju 61007, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Appl Chem, Daegu 41566, South Korea ⓘ ⓘ 16425858100; 57205247060; 55446279600; 57205250433; 57210160353; 35082028100; 35074781200 ⓘ jeonj@knu.ac.kr;biopark@kribb.re.kr; ⓘ BIOCONJUGATE CHEMISTRY ⓘ BIOCONJUGATE CHEM ⓘ 1043-1802 1520-4812 31 11 SCIE BIOCHEMICAL RESEARCH METHODS;BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, ORGANIC ⓘ 2020 4.774 14.7 0.63 2025-06-25 ⓘ 12 12 ⓘ ⓘ ⓘ Animals; Cyclobutanes; Heterografts; Humans; Integrin alphaVbeta3; Mice; Mice, Inbred BALB C; Molecular Probes; Neoplasms; Optical Imaging; Peptides, Cyclic; Phenols; Photoacoustic Techniques; Solubility; Spectroscopy, Near-Infrared; Amino acids; Diseases; Fluorescence imaging; Infrared devices; arginylglycylaspartic acid; benzoindole derived squaraine cyclic arginine glycine aspartic acid peptide conjugate; cyclopeptide; fluorescent dye; isoflurane; ketamine; unclassified drug; vitronectin receptor; xylazine; cyclic arginine-glycine-aspartic acid peptide; cyclobutane derivative; cyclopeptide; phenol derivative; squaraine; vitronectin receptor; Fluorescence imaging; Imaging agent; In-vivo; Integrins; Modulars; Molecular Probes; Near-infrared fluorescence; Photo-acoustic imaging; Squaraines; Vivo fluorescence; animal experiment; animal model; animal tissue; Article; cancer cell; controlled study; data analysis software; drug absorption; drug conjugation; drug design; drug protein binding; drug synthesis; drug targeting; ex vivo study; fluorescence imaging; gene overexpression; human; human cell; in vitro study; in vivo study; male; malignant neoplasm; molecular probe; mouse; multimodal imaging; nonhuman; photoacoustics; tumor xenograft; animal; Bagg albino mouse; chemistry; fluorescence imaging; metabolism; molecular probe; near infrared spectroscopy; neoplasm; photoacoustics; procedures; solubility; xenograft; Photoacoustic effect ⓘ English 2020 2020-11-18 10.1021/acs.bioconjchem.0c00533 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Difference between paediatric Crohn's disease and ulcerative colitis at diagnosis in Korea: results from a multicentre, registry-based, retrospective cohort study ⓘ ⓘ Choe, B. H.; Kang, B.; Suh, H. R.; Kim, E. S.; Park, J. H.; Kim, M. J.; Choe, Y. H.; Kim, S.; Koh, H.; Lee, Y. J.; Park, J. H.; Ryoo, E. ⓘ Kyungpook Natl Univ, Childrens Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Dept Pediat, Samsung Med Ctr, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Pediat, Severance Hosp, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Pediat, Childrens Hosp, Yangsan, South Korea; Gachon Univ, Gil Med Ctr, Coll Med, Dept Pediat, Incheon, South Korea ⓘ Choe, Byung-Ho/KSM-6251-2024; Park, Jun/HPH-3570-2023; 康, 奔/JMQ-0812-2023 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 14 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2020 9.071 14.7 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-01 ⓘ 바로가기 바로가기
○ Meeting Abstract ⓘ Dynamics of intestinal inflammation and microbial dysbiosis in pregnant women with IBD and their infants ⓘ ⓘ Tarassishin, L.; Kim, E.; Eisele, C.; Barre, A.; Thjomoe, A.; Mork, E.; Dubinsky, M.; Stone, J.; Nair, N.; Debebe, A.; Hawkins, K.; Rendon, A.; Sabino, J.; Torres, J.; Colombel, J. F.; Peter, I.; Hu, J. ⓘ Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Cochin Univ Hosp, Gastroenterol Div, Paris, France; Calpro AS, Lysaker, Norway; Icahn Sch Med Mt Sinai, Div Pediat Gastroenterol & Hepatol, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA; Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium; Hosp Beatriz Angelo, Gastroenterol Div, Loures, Portugal; Icahn Sch Med Mt Sinai, Dept Med, Div Gastroenterol, New York, NY 10029 USA ⓘ ; Sabino, João/L-1093-2019 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 14 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2020 9.071 14.7 ⓘ 1 ⓘ ⓘ ⓘ ⓘ English 2020 2020-01 ⓘ 바로가기 바로가기
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