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○ Meeting Abstract ⓘ Lower glucose level associated with increased risk for post-dural puncture headache ⓘ ⓘ Hwang, J. ⓘ Kyungpook Natl Univ, Neurol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ EUROPEAN JOURNAL OF NEUROLOGY ⓘ EUR J NEUROL ⓘ 1351-5101 1468-1331 27 SCIE CLINICAL NEUROLOGY;NEUROSCIENCES ⓘ 2020 6.089 14.2 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-05 ⓘ 바로가기 바로가기
○ ○ Article ⓘ Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women ⓘ We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women. ⓘ Wong, Jason Y. Y.; Zhang, Han; Hsiung, Chao A.; Shiraishi, Kouya; Yu, Kai; Matsuo, Keitaro; Wong, Maria Pik; Hong, Yun-Chul; Wang, Jiucun; Seow, Wei Jie; Wang, Zhaoming; Song, Minsun; Kim, Hee Nam; Chang, I-Shou; Chatterjee, Nilanjan; Hu, Wei; Wu, Chen; Mitsudomi, Tetsuya; Zheng, Wei; Kim, Jin Hee; Seow, Adeline; Caporaso, Neil E.; Shin, Min-Ho; Chung, Lap Ping; An, She-Juan; Wang, Ping; Yang, Yang; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu-Chao; Kim, Young Tae; Cai, Qiuyin; Yin, Zhihua; Kim, Young-Chul; Bassig, Bryan A.; Chang, Jiang; Ho, James Chung N.; Ji, Bu-Tian; Daigo, Yataro; Ito, Hidemi; Momozawa, Yukihide; Ashikawa, Kyota; Kamatani, Yoichiro; Honda, Takayuki; Hosgood, H. Dean; Sakamoto, Hiromi; Kunitoh, Hideo; Tsuta, Koji; Watanabe, Shun-Ichi; Kubo, Michiaki; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Tsuboi, Masahiro; Goto, Koichi; Shi, Jianxin; Song, Lei; Hua, Xing; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Shimizu, Kimihiro; Tanaka, Kazumi; Wei, Fusheng; Matsuda, Fumihiko; Su, Jian; Kim, Yeul Hong; Oh, In-Jae; Song, Fengju; Su, Wu-Chou; Chen, Yu-Min; Chang, Gee-Chen; Chen, Kuan-Yu; Huang, Ming-Shyan; Chien, Li-Hsin; Xiang, Yong-Bing; Park, Jae Yong; Kweon, Sun-Seog; Chen, Chien-Jen; Lee, Kyoung-Mu; Blechter, Batel; Li, Haixin; Gao, Yu-Tang; Qian, Biyun; Lu, Daru; Liu, Jianjun; Jeon, Hyo-Sung; Hsiao, Chin-Fu; Sung, Jae Sook; Tsai, Ying-Huang; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Wang, Wen-Chang; Chung, Charles C.; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Berndt, Sonja, I; Wu, Wei; Pang, Herbert; Li, Yuqing; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, C. H.; Zhu, Meng; Chen, Chung-Hsing; Yang, Tsung-Ying; Xu, Jun; Guan, Peng; Tan, Wen; Wang, Chih-Liang; Hsin, Michael; Sit, Ko-Yung; Chen, Ying; Choi, Yi Young; Hung, Jen-Yu; Kim, Jun Suk; Yoon, Ho Il; Lin, Chien-Chung; Park, In Kyu; Xu, Ping; Wang, Yuzhuo; He, Qincheng; Perng, Reury-Perng; Chen, Chih-Yi; Vermeulen, Roel; Wu, Junjie; Lim, Wei-Yen; Chen, Kun-Chieh; Li, Yao-Jen; Li, Jihua; Chen, Hongyan; Yu, Chong-Jen; Jin, Li; Chen, Tzu-Yu; Jiang, Shih-Sheng; Liu, Jie; Yamaji, Taiki; Hicks, Belynda; Wyatt, Kathleen; Li, Shengchao A.; Dai, Juncheng; Ma, Hongxia; Jin, Guangfu; Song, Bao; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yangwu; Cui, Ping; Iwasaki, Motoki; Shimazu, Taichi; Tsugane, Shoichiro; Zhu, Junjie; Yang, Kaiyun; Jiang, Gening; Fei, Ke; Wu, Guoping; Lin, Hsien-Chin; Chen, Hui-Ling; Fang, Yao-Huei; Tsai, Fang-Yu; Hsieh, Wan-Shan; Yu, Jinming; Stevens, Victoria L.; Laird-Offringa, Ite A.; Marconett, Crystal N.; Rieswijk, Linda; Chao, Ann; Yang, Pan-Chyr; Shu, Xiao-Ou; Wu, Tangchun; Wu, Y. L.; Lin, Dongxin; Chen, Kexin; Zhou, Baosen; Huang, Yun-Chao; Kohno, Takashi; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing ⓘ NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA; Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan; Natl Canc Ctr, Div Genome Biol, Res Inst, Tokyo, Japan; Aichi Canc Ctr, Div Canc Epidemiol & Prevent, Res Inst, Nagoya, Aichi, Japan; Nagoya Univ, Dept Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan; Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Peoples R China; Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea; Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China; Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China; Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore; Leidos Biomed Res Inc, Canc Genom Res Lab, Gaithersburg, MD USA; St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA; Sookmyung Womens Univ, Dept Stat, Seoul, South Korea; Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju, South Korea; Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan; Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA; Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China; Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China; Kinki Univ, Div Thorac Surg, Sch Med, Sayama, Osaka, Japan; Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA; Vanderbilt Ingram Canc Ctr, Nashville, TN USA; Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea; Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangdong Lung Canc Inst, Guangzhou, Peoples R China; Guangdong Acad Med Sci, Guangdong Gen Hosp, Canc Ctr, Guangzhou, Peoples R China; Tianjin Med Univ, Natl Clin Res Ctr Canc, Dept Radiotherapy, Key Lab Canc Prevent & Therapy,Canc Inst & Hosp, Tianjin, Peoples R China; Shanghai Pulm Hosp, Shanghai, Peoples R China; Tianjin Med Univ, Dept Epidemiol & Biostat, Canc Inst & Hosp, Tianjin, Peoples R China; Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Cent Hosp, Nagoya, Aichi, Japan; Seoul Natl Univ, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Coll Med, Seoul, South Korea; China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China; Chonnam Natl Univ, Hwasun Eup, Lung & Esophageal Canc Clin, Hwasun Eup, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam Rd, Hong Kong, Peoples R China; Shiga Univ Med Sci, Dept Med Oncol, Otsu, Shiga, Japan; Shiga Univ Med Sci, Canc Ctr, Otsu, Shiga, Japan; Univ Tokyo, Res Hosp, Ctr Antibody & Vaccine Therapy, Inst Med Sci, Tokyo, Japan; Aichi Canc Ctr, Div Canc Informat & Control, Res Inst, Nagoya, Aichi, Japan; Nagoya Univ, Dept Descript Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan; RIKEN, Lab Genotyping Dev, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan; RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan; Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA; Natl Canc Ctr, Div Genet, Res Inst, Tokyo, Japan; Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan; Kansai Med Univ, Dept Pathol & Lab Med, Osaka, Japan; Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan; Kanagawa Canc Ctr, Mol Pathol & Genet Div, Res Inst, Yokohama, Kanagawa, Japan; Kanagawa Canc Ctr, Dept Thorac Surg, Yokohama, Kanagawa, Japan; Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr EPOC, Div Translat Res, Chiba, Japan; Natl Canc Ctr Hosp East, Dept Thorac Surg, Chiba, Japan; Natl Canc Ctr Hosp East, Dept Thorac Oncol, Chiba, Japan; Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Genom Med, Osaka, Japan; Akita Univ, Grad Sch Med, Dept Cellular & Organ Pathol, Akita, Japan; Akita Univ, Grad Sch Med, Dept Thorac Surg, Akita, Japan; Gunma Univ Hosp, Dept Integrat, Ctr Gen Surg, Gunma, Japan; China Natl Environm Monitoring Ctr, Beijing, Peoples R China; Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan; Korea Univ, Coll Med, Dept Internal Med, Div Oncol Hematol,Anam Hosp, Seoul, South Korea; Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan; Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan; Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan; Natl Yang Ming Univ, Fac Med, Sch Med, Taipei, Taiwan; Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan; Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan; Natl Taiwan Univ, Coll Med, Taipei, Taiwan; I Shou Univ, E Da Canc Hosp, Sch Med, Dept Internal Med, Kaohsiung, Taiwan; Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst,Sch Med, State Key Lab Oncogene & Related Genes, Shanghai, Peoples R China; Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Dept Epidemiol,Sch Med, Shanghai, Peoples R China; Kyungpook Natl Univ, Lung Canc Ctr, Med Ctr, Daegu, South Korea; Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun Eup, South Korea; Acad Sinica, Genom Res Ctr, Taipei, Taiwan; Korea Natl Open Univ, Dept Environm Hlth, Seoul, South Korea; Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China; Genome Inst Singapore, Dept Human Genet, Singapore, Singapore; Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China; Kyungpook Natl Univ, Canc Res Ctr, Med Ctr, Daegu, South Korea; Chiayi Chang Gung Mem Hosp, Div Pulm & Crit Care Med, Chiayi, Taiwan; Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Peoples R China; Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan, Peoples R China; Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China; Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan; Univ Hong Kong, Sch BioMed Sci, Hong Kong, Peoples R China; Canc Prevent Inst Calif, Fremont, CA USA; Catholic Univ Korea, Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea; Huazhong Univ Sci & Technol, Union Hosp, Canc Ctr, Dept Oncol, Wuhan, Peoples R China; Univ Hong Kong, Li Ka Shing LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China; Univ Liaoning Prov, Key Lab Canc Etiol & Intervent, Shenyang, Peoples R China; Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan; Univ Hong Kong, Queen Mary Hosp, Dept Cardiothorac Surg, Hong Kong, Peoples R China; Univ Hong Kong, Dept Med, Hong Kong, Peoples R China; Korea Univ, Coll Med, Dept Internal Med, Div Med Oncol,Guro Hosp, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Wuhan Iron & Steel Corp, Dept Oncol, Staff Worker Hosp, Wuhan, Peoples R China; Taipei Vet Gen Hosp, Chest Dept, Taipei, Taiwan; Chung Shan Med Univ, Inst Med, Taichung, Taiwan; Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan; Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands; Agcy Integrated Care, Singapore, Singapore; Qujing Ctr Dis Control & Prevent, Sanjiangdadao, Qujing, Peoples R China; Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan; Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Oncol, Jinan, Peoples R China; Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan; Kunming Med Univ, Yunnan Canc Hosp, Yunnan Canc Ctr, Dept Thorac Surg,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China; Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA; Univ Southern Calif, Norris Comprehens Canc Ctr, Keck Sch Med, Dept Surg,Dept Biochem & Mol Med, Los Angeles, CA 90007 USA; Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci Div, Berkeley, CA 94720 USA; NCI, Ctr Global Hlth, Bethesda, MD 20892 USA; Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China ⓘ Park, MK/GVU-0647-2022; Shimazu, Taichi/A-4470-2015; Yoon, Ho/J-5567-2012; Ho, James/C-4308-2009; Lee, Hyo-Suk/J-5618-2012; Chang, Yu-Chan/W-3582-2019; Wang, Jiucun/J-8744-2012; Kweon, Sun-Seog/AAZ-4732-2021; Yi-Wen, Chen/G-7275-2016; Kim, Jin/AET-7817-2022; Wang, Zhaoming/R-5527-2018; Kim, Young/J-2744-2012; Chen, Hongyan/R-8238-2019; Hsiao, Chin-Fu/E-3993-2010; An, Shejuan/A-9573-2014; Chen, Chien-Jen/N-4723-2019; Kang, Chang-Hyun/J-5364-2012; Hung, Jen-Yu/D-4522-2009; Kim, Min Chul/IYJ-9897-2023; Vermeulen, Roel/F-8037-2011; Tsugane, Shoichiro/A-2424-2015; Wu, Yi-Long/C-3396-2008; Su, Jian/KEE-9971-2024; Shiraishi, Kouya/MFZ-9526-2025; Chen, Huanyang/C-6323-2009; Kim, Tae-You/J-2750-2012; Chanock, Stephen/AGL-9345-2022; Yu, Kai/HOF-9693-2023; Guan, Peng/GWM-9170-2022; jin, li/IWU-4648-2023; shen, hong/HTQ-6147-2023; Song, MIN-SUN/LTD-5990-2024; Chang, Hui/AGD-4270-2022; Hong, Yun-Chul/J-5725-2012; Lilly, Christa/R-6644-2017; Rieswijk, Linda/AAJ-3190-2020; Li, Xinyong/AAX-4388-2020; CHEN, SI/GZL-4800-2022; Mao, Lin/IST-9013-2023; Li, Yuqing/AAR-9383-2021; Honda, Takayuki/W-3442-2019; Cheng, Ying/LSL-5582-2024; xu, ping/KSM-3277-2024; Shu, Xiao'Ou/KPA-5613-2024; Berndt, Sonja/J-8423-2016; Liu, Jianjun/AAK-4989-2020; TOUZE, Emmanuel/HKO-8647-2023; Dai, Juncheng/HMO-9370-2023; zhu, junjie/JDV-8211-2023; Yeager, Meredith/AAA-5322-2020; Oh, In-Jae/AAG-5919-2020; YANG, PAN-CHYR/E-5426-2016; jiang, jun/GWC-9329-2022; Chung, Lap/C-4258-2009; Chang, I-Shou/D-2084-2010; Jiang, Shih/C-6187-2011; LIN, HUI-CHEN/AAA-8973-2021; Li, Xingchuan/JFB-4764-2023; wang, chih-liang/GSD-6038-2022; Tao, Cheng-an/H-4232-2014; Kohno, Takashi/M-8823-2013; Carrot-Zhang, Jian/K-8618-2019; Zheng, Wei/O-3351-2013; Matsuo, Keitaro/H-6758-2019; Chen, Kexin/ISV-0772-2023; Goto, Akiteru/P-5775-2014; Lu, Jiaying/U-7673-2017; Zhang, Xuchao/P-9009-2015; Chen, Hongyu/Q-3709-2018; Rieswijk, Linda/T-3989-2017; Cheng, wen chien/KCK-1394-2024; Sung, Jae/AAA-3882-2021; YATABE, Yasushi/J-6461-2014; Offringa, Ite/R-4101-2019; Wang, Yangyang/GXH-5679-2022 ⓘ 19336599300; 55846804300; 57202456495; 7202509586; 7403385290; 7401602814; 7403907887; 7403393231; 57221357827; 55511075900; 35346086300; 56723259300; 7410134504; 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7102702769; 7403932080; 55630916600; 7404815278; 55569782000; 55520003300; 57216428242; 7401906866; 23976179000; 7201820330; 57218362875; 7006047196; 34572851700; 23970641100 ⓘ jason.wong@nih.gov; ⓘ GENOMICS ⓘ GENOMICS ⓘ 0888-7543 1089-8646 112 2 SCIE BIOTECHNOLOGY & APPLIED MICROBIOLOGY;GENETICS & HEREDITY ⓘ 2020 5.736 14.2 0.89 2025-06-25 ⓘ 17 14 Tuberculosis; Lung cancer; Lung adenocarcinoma; Mendelian randomization; Pathway analysis ⓘ CANCER SUSCEPTIBILITY LOCI; PULMONARY TUBERCULOSIS; RISK; DISEASE; VARIANTS; SMOKERS; APOPTOSIS; MEN ⓘ Lung adenocarcinoma; Lung cancer; Mendelian randomization; Pathway analysis; Tuberculosis ⓘ Adenocarcinoma of Lung; Asian Continental Ancestry Group; Female; Genome-Wide Association Study; Humans; Lung Neoplasms; Mendelian Randomization Analysis; Non-Smokers; Tuberculosis, Pulmonary; HLA DQA1 antigen; adult; Article; controlled study; DLG2 gene; East Asian; female; FHAD1 gene; gene; genetic association; genetic susceptibility; genetic variability; genome-wide association study; HLA DQA1 gene; human; LRRC69 gene; lung adenocarcinoma; major clinical study; MEIS2 gene; Mendelian randomization analysis; never smoker; observational study; pathway analysis; priority journal; single nucleotide polymorphism; statistical analysis; tuberculosis; ZFPM2 gene; Asian continental ancestry group; genetics; lung adenocarcinoma; lung tuberculosis; lung tumor ⓘ English 2020 2020-03 10.1016/j.ygeno.2019.07.008 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ectopic expression of miRNA172 in tomato (Solanum lycopersicum) reveals novel function in fruit development through regulation of an AP2 transcription factor ⓘ Background MicroRNAs (miRNAs) are short non-coding RNAs that can influence gene expression via diverse mechanisms. Tomato is a fruit widely consumed for its flavor, culinary attributes, and high nutritional quality. Tomato fruit are climacteric and fleshy, and their ripening is regulated by endogenous and exogenous signals operating through a coordinated genetic network. Much research has been conducted on mechanisms of tomato fruit ripening, but the roles of miRNA-regulated repression/expression of specific regulatory genes are not well documented. Results In this study, we demonstrate that miR172 specifically targets fourSlAP2transcription factor genes in tomato. Among them,SlAP2awas repressed by the overexpression ofSlmiR172, manifesting in altered flower morphology, development and accelerated ripening.miR172over-expression lines specifically repressedSlAP2a, enhancing ethylene biosynthesis, fruit color and additional ripening characteristics. Most previously described ripening-regulatory genes, includingRIN-MADS,NR,TAGL1andLeHB-1were not influenced by miR172 whileCNRshowed altered expression. Conclusions Tomato fruit ripening is directly influenced by miR172 targeting of theAPETALA2transcription factor,SlAP2a, with minimal influence over additional known ripening-regulatory genes. miR172a-guidedSlAP2aexpression provides insight into another layer of genetic control of ripening and a target for modifying the quality and nutritional value of tomato and possibly other fleshy fruit crops. ⓘ Chung, Mi-Young; Nath, Ujjal Kumar; Vrebalov, Julia; Gapper, Nigel; Lee, Je Min; Lee, Do-Jin; Kim, Chang Kil; Giovannoni, James ⓘ Sunchon Natl Univ, Dept Agr Educ, Sunchon, South Korea; Bangladesh Agr Univ, Dept Genet & Plant Breeding, Mymensingh 2202, Bangladesh; Cornell Univ, Boyce Thompson Inst Plant Res, Tower Rd, Ithaca, NY 14853 USA; Kyungpook Natl Univ, Dept Hort, Daegu, South Korea; USDA ARS, Robert W Holley Ctr Agr & Hlth, Ithaca, NY 14853 USA ⓘ Lee, Je/AAE-7496-2020; Giovannoni, James J./LTE-4376-2024; Lee, Je Min/F-9797-2014 ⓘ 24821361600; 56460413300; 6602559984; 9737390500; 8885729900; 7406659787; 7409880701; 7003348202 ⓘ ckkim@knu.ac.kr;jjg33@cornell.edu; ⓘ BMC PLANT BIOLOGY ⓘ BMC PLANT BIOL ⓘ 1471-2229 20 1 SCIE PLANT SCIENCES ⓘ 2020 4.215 14.3 2.54 2025-06-25 ⓘ 45 48 Tomato; SlAP2a; miR172; Fruit ripening; Ethylene ⓘ FLORAL ORGAN IDENTITY; MADS-BOX GENE; SMALL RNAS; CONSERVED MICRORNAS; NEGATIVE REGULATOR; RIPENING MUTANTS; PLANT MICRORNAS; ABC MODEL; ARABIDOPSIS; IDENTIFICATION ⓘ Ethylene; Fruit ripening; miR172; SlAP2a; Tomato ⓘ Ectopic Gene Expression; Fruit; Gene Regulatory Networks; Homeodomain Proteins; Lycopersicon esculentum; MicroRNAs; Plant Proteins; homeodomain protein; microRNA; plant protein; ectopic expression; fruit; gene regulatory network; genetics; growth, development and aging; metabolism; tomato ⓘ English 2020 2020-06-19 10.1186/s12870-020-02489-y ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Silicon-induced thermotolerance in Solanum lycopersicum L. via activation of antioxidant system, heat shock proteins, and endogenous phytohormones ⓘ BackgroundAbiotic stresses (e.g., heat or limited water and nutrient availability) limit crop production worldwide. With the progression of climate change, the severity and variation of these stresses are expected to increase. Exogenous silicon (Si) has shown beneficial effects on plant growth; however, its role in combating the negative effects of heat stress and their underlying molecular dynamics are not fully understood.ResultsExogenous Si significantly mitigated the adverse impact of heat stress by improving tomato plant biomass, photosynthetic pigments, and relative water content. Si induced stress tolerance by decreasing the concentrations of superoxide anions and malondialdehyde, as well as mitigating oxidative stress by increasing the gene expression for antioxidant enzymes (peroxidases, catalases, ascorbate peroxidases, superoxide dismutases, and glutathione reductases) under stress conditions. This was attributed to increased Si uptake in the shoots via the upregulation of low silicon (SlLsi1 and SlLsi2) gene expression under heat stress. Interestingly, Si stimulated the expression and transcript accumulation of heat shock proteins by upregulating heat transcription factors (Hsfs) such as SlHsfA1a-b, SlHsfA2-A3, and SlHsfA7 in tomato plants under heat stress. On the other hand, defense and stress signaling-related endogenous phytohormones (salicylic acid [SA]/abscisic acid [ABA]) exhibited a decrease in their concentration and biosynthesis following Si application. Additionally, the mRNA and gene expression levels for SA (SlR1b1, SlPR-P2, SlICS, and SlPAL) and ABA (SlNCEDI) were downregulated after exposure to stress conditions.ConclusionSi treatment resulted in greater tolerance to abiotic stress conditions, exhibiting higher plant growth dynamics and molecular physiology by regulating the antioxidant defense system, SA/ABA signaling, and Hsfs during heat stress. ⓘ Khan, Adil; Khan, Abdul Latif; Imran, Muhammad; Asaf, Sajjad; Kim, Yoon-Ha; Bilal, Saqib; Numan, Muhammad; Al-Harrasi, Ahmed; Al-Rawahi, Ahmed; Lee, In-Jung ⓘ Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea ⓘ Asaf, Sajjad/ABA-3647-2021; Khan, Abdul/H-5910-2011; Numan, Muhammad/AAB-5344-2022; Ul-Hamid, Anwar/B-7297-2015; Imran, Muhammad/AFL-6590-2022; Lee, In-Jung/GLS-0432-2022; Khan, Adil/AAC-5160-2022 ⓘ 57200917937; 26639372800; 58282433800; 56595059900; 57224866763; 57031617400; 59012967300; 6506093146; 7801308442; 16425830900 ⓘ latifepm78@yahoo.co.uk; ⓘ BMC PLANT BIOLOGY ⓘ BMC PLANT BIOL ⓘ 1471-2229 20 1 SCIE PLANT SCIENCES ⓘ 2020 4.215 14.3 5.56 2025-06-25 ⓘ 59 88 Solanum lycopersicum L; Silicon; Heat stress; Antioxidant; Heat shock protein ⓘ STRESS TRANSCRIPTION FACTOR; ALLEVIATES SALT STRESS; BACILLUS-AMYLOLIQUEFACIENS RWL-1; LIPID-PEROXIDATION; EXOGENOUS SILICON; DROUGHT TOLERANCE; ENZYME-ACTIVITIES; ABIOTIC STRESS; TOMATO PLANTS; CHLOROPHYLL FLUORESCENCE ⓘ Antioxidant; Heat shock protein; Heat stress; Silicon; Solanum lycopersicum L ⓘ Abscisic Acid; Antioxidants; Chlorophyll; Heat-Shock Proteins; Lycopersicon esculentum; Plant Growth Regulators; Plant Proteins; Real-Time Polymerase Chain Reaction; Silicon; Thermotolerance; abscisic acid; antioxidant; chlorophyll; heat shock protein; phytohormone; plant protein; silicon; drug effect; heat tolerance; metabolism; physiology; real time polymerase chain reaction; tomato ⓘ English 2020 2020-06-03 10.1186/s12870-020-02456-7 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling ⓘ Background: The prevalence of cardiovascular diseases (CVDs) is increasing at a high rate, and the available treatment options, sometimes, have complications which necessitates the need to develop safer and efficacious approaches. Ethnomedicinal applications reportedly reduce CVD risk. Ulmus parvifolia Jacq. (Ulmaceae) commonly known as Chinese Elm or Lacebark Elm, is native to China, Japan, and Korea. It exhibits anti-inflammatory, antiviral, and anticancer properties, but its anti-platelet properties have not yet been elucidated. Purpose: To investigate the pharmacological anti-platelet and anti-thrombotic effects of U. parvifolia bark extract. Study Design and Methods: Human and rat washed platelets were prepared; light transmission aggregometry and scanning electron microscopy was performed to assess platelet aggregation and the change in platelet shape, respectively. Intracellular calcium mobilization, ATP release, and thromboxane-B2 production were also measured. Integrin alpha(IIb)beta(3) activation was analyzed in terms of fibrinogen binding, fibronectin adhesion, and clot retraction. The expression of MAPK, Src, and PI3K/Akt pathway proteins was examined. Cyclic nucleotide signaling pathway was evaluated via cAMP elevation and VASP phosphorylation. Anti-thrombotic activity of the extract was evaluated in vivo using an arteriovenous shunt rat model, whereas its effect on hemostasis in mice was assessed via bleeding time assay. Results: U. parvifolia extract significantly inhibited human and rat platelet aggregation in a dose-dependent manner along with inhibition of calcium mobilization, dense granule secretion, and TxB2 production. Integrin alpha(IIb)beta(3) mediated inside-out and outside-in signaling events, as evidenced by the inhibition of fibrinogen binding, fibronectin adhesion, and clot retraction. The extract significantly reduced phosphorylation of Src, MAPK (ERK, JNK, and p38(MAPK)), and PI3K/Akt pathway proteins. Cyclic-AMP levels were elevated in U. parvifolia-treated platelets, while PKA alpha beta gamma and VASP(ser157) phosphorylation was enhanced. U. parvifolia reduced thrombus weight in rats and moderately increased bleeding time in mice. Conclusion: U. parvifolia modulates platelet responses and inhibit thrombus formation by regulating integrin alpha(IIb)beta(3) mediated inside-out and outside-in signaling events and cAMP signaling pathway. ⓘ Irfan, Muhammad; Kwon, Hyuk-Woo; Lee, Dong-Ha; Shin, Jung-Hae; Yuk, Heung Joo; Kim, Dong-Seon; Hong, Seung-Bok; Kim, Sung-Dae; Rhee, Man Hee ⓘ Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu, South Korea; Far East Univ, Dept Biomed Lab Sci, Eumseong, South Korea; Namseoul Univ, Mol Diagnost Res Inst, Dept Biomed Lab Sci, Cheonan, South Korea; Korea Inst Oriental Med, Herbal Med Res Div, Daejeon, South Korea; Chungbuk Hlth & Sci Univ, Dept Clin Lab Sci, Chungbuk, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan, South Korea ⓘ Yuk, Heung/T-5882-2019; Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021 ⓘ 35069404400; 55200547400; 57208891222; 56244056800; 36969874600; 56947571300; 9237099500; 55156746000; 57211035357 ⓘ sdkim@dirams.co.kr;rheemh@knu.ac.kr; ⓘ FRONTIERS IN PHARMACOLOGY ⓘ FRONT PHARMACOL ⓘ 1663-9812 11 SCIE PHARMACOLOGY & PHARMACY ⓘ 2020 5.811 14.3 0.89 2025-06-25 ⓘ 11 11 U. parvifolia; ethnomedicine; platelet; integrin alpha(IIb)beta(3); cyclic-AMP; VASP(ser157) ⓘ VASODILATOR-STIMULATED PHOSPHOPROTEIN; GREEN TEA CATECHINS; CARDIOVASCULAR-DISEASE; PROTEIN-KINASE; ANTIPLATELET; PHOSPHORYLATION; GINSENOSIDES; ACTIVATION; MECHANISMS; RESISTANCE ⓘ cyclic-AMP; ethnomedicine; integrin α<sub>IIb</sub>β<sub>3</sub>; platelet; U. parvifolia; VASP<sup>ser157</sup> ⓘ 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide; adenosine triphosphate; alphaIIbbeta3 integrin; anticoagulant agent; beta3 integrin; cyclic AMP; cyclic AMP dependent protein kinase; cyclic nucleotide; fibrinogen; fibronectin; mitogen activated protein kinase; mitogen activated protein kinase p38; phosphatidylinositol 3 kinase; plant extract; protein kinase A alpha; protein kinase A beta; protein kinase A gamma; protein kinase B; protein tyrosine kinase; stress activated protein kinase; thromboxane B2; Ulmus parvifolia extract; unclassified drug; vasodilator stimulated phosphoprotein; animal experiment; antithrombotic activity; Article; assay; bleeding time assay; blood clot retraction; calcium cell level; calcium mobilization; controlled study; elm; enzyme activation; enzyme inhibition; enzyme regulation; enzyme synthesis; hemostasis; human; in vivo study; light; light transmission aggregometry; male; nonhuman; Pi3K/Akt signaling; protein binding; protein expression; protein phosphorylation; protein secretion; rat; scanning electron microscopy; signal transduction; thrombocyte aggregation; thrombocyte function; traditional medicine; Ulmus parvifolia ⓘ English 2020 2020-05-19 10.3389/fphar.2020.00698 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The synthesis of tire grade ZnO from top submerged lance (TSL) furnace flue dust generated in Cu recycling industries ⓘ TSL flue dust is a waste residue, rich in Zn, generating from the pyrometallurgical process of Cu recycling and constitutes a potential raw material for ZnO production. In order to valorize this waste by introducing a novel process, its selective impurity removal by integrating different commercially viable hydrometallurgical technologies was investigated on both laboratory and pilot scale. Special attention was given to determine the usability of the wastewater originated from the Cu recycling industry as a leaching agent. An average of 83% of Zn could be extracted from the TSL flue dust by employing the wastewater leaching with maximum selectivity. Purification of the leached solution was carried out by subsequently subjecting into cementation, oxidation-precipitation, 2-step neutralization, re-pulping, and drying steps, respectively. Recoverability of the Cu value of the flue dust by controlling cementation time and identification of Mn as the cause of the product color issue were remarkable approaches obtained from the purification process. Commercially salable ZnO (tire grade, purity > 99.0%) could be synthesized as the final product by employing this novel process after the verification of technical and economic feasibility. ⓘ Wijenayake, Janaka Jayamini; Sohn, Ho-Sang ⓘ LS Nikko Copper Inc, Ulsan 44997, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Met Engn, Daegu 41566, South Korea ⓘ ⓘ 57203843664; 7201426373 ⓘ sohn@knu.ac.kr; ⓘ HYDROMETALLURGY ⓘ HYDROMETALLURGY ⓘ 0304-386X 1879-1158 198 SCIE METALLURGY & METALLURGICAL ENGINEERING ⓘ 2020 4.156 14.4 0.46 2025-06-25 ⓘ 4 6 TSL flue dust; Wastewater leaching; Tire grade ZnO; Hydrometallurgy ⓘ ZINC; CEMENTATION; RECOVERY; REMOVAL ⓘ Hydrometallurgy; Tire grade ZnO; TSL flue dust; Wastewater leaching ⓘ Cementing (shafts); Dust; Flues; Fly ash; II-VI semiconductors; Leaching; Oxide minerals; Purification; Pyrometallurgy; Recycling; Removal; Wastewater reclamation; Zinc oxide; Economic feasibilities; Hydrometallurgical technology; Impurity removal; Leaching agents; Maximum selectivity; Purification process; Pyro-metallurgical process; Recycling industry; Copper ⓘ English 2020 2020-12 10.1016/j.hydromet.2020.105466 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas peel suppresses microglia-associated neuroinflammation in vitro ⓘ ⓘ Yun, Hyun; Lim, Ji; Oh, Jisun; Kim, Jong-Sang ⓘ Sch Food Sci & Biotechnol BK21PLUS, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.07060 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ A simple metastatic brain cancer model using human embryonic stem cell-derived cerebral organoids ⓘ Every year, hundreds of thousands of people die because of metastatic brain cancer. Most metastatic cancer research uses 2D cell culture or animal models, but they have a few limitations, such as difficulty reproducing human tissue structures. This study developed a simple 3D in vitro model to better replicate brain metastasis using human cancer cells and human embryonic stem cell-derived cerebral organoids (metastatic brain cancer cerebral organoid [MBCCO]). The MBCCO model successfully reproduced metastatic cancer processes, including cell adhesion, proliferation, and migration, in addition to cell-cell interactions. Using the MBCCO model, we demonstrated that lung-specific X protein (LUNX) plays an important role in cell proliferation and migration or invasion. We also observed astrocyte accumulation around and their interaction with cancer cells through connexin 43 in the MBCCO model. We analyzed whether the MBCCO model can be used to screen drugs by measuring the effects of gefitinib, a well-known anticancer agent. We also examined the toxicity of gefitinib using normal cerebral organoids (COs). Therefore, the MBCCO model is a powerful tool for modeling human metastatic brain cancer in vitro and can also be used to screen drugs. ⓘ Choe, Mu Seog; Kim, Joong Sun; Yeo, Han Cheol; Bae, Chang Min; Han, Ho Jae; Baek, Kyungmin; Chang, Woochul; Lim, Kyung Seob; Yun, Seung Pil; Shin, In-Sik; Lee, Min Young ⓘ Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Vessel Organ Interact Res Ctr MRC, Daegu, South Korea; Korea Inst Oriental Med, K Herb Res Ctr, Daejeon, South Korea; Seoul Natl Univ, Dept Vet Physiol, Coll Vet Med, Seoul, South Korea; Daegu Haany Univ, Dept Cardiovasc & Neurol Dis, Coll Oriental Med, Daegu, South Korea; Pusan Natl Univ, Dept Biol Educ, Coll Educ, Busan, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Cheongju, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Pharmacol, Jinju, South Korea; Chonnam Natl Univ, Dept Vet Pharmacol, Coll Vet Med, BK21 Project Team, Gwangju, South Korea ⓘ Han, Ho/M-1476-2016; shin, i/JCE-1227-2023 ⓘ 57202926165; 7601371367; 57202931191; 57211800962; 7401968982; 56421484100; 12797539700; 36470521900; 25951635400; 35202055600; 15119890400 ⓘ vetmedic@knu.ac.kr; ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 12 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 1.23 2025-06-25 ⓘ 25 25 brain metastasis; lung cancer; MBCCO model ⓘ EXTRACELLULAR-MATRIX; LUNG-CANCER; 3RD-DIMENSION; CULTURE; GAP ⓘ brain metastasis; lung cancer; MBCCO model ⓘ A549 Cells; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Adhesion; Cell Communication; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; HEK293 Cells; Human Embryonic Stem Cells; Humans; Neurons; Organoids; caspase 3; connexin 43; DCX protein; doublecortin; eomesodermin; gefitinib; glial fibrillary acidic protein; ionized calcium binding adaptor molecule 1; lung specific X protein; microtubule associated protein 2; nerve cell adhesion molecule; neuron specific class III beta tubulin 1; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; protein; protein Bax; protein bcl 2; transcription factor PAX6; transcription factor Sox2; unclassified drug; antineoplastic agent; Article; astrocyte; brain cancer; brain metastasis; cancer model; cell adhesion; cell interaction; cell invasion; cell migration; cell proliferation; cerebral organoid; concentration response; controlled study; down regulation; embryo; gap junction; gene function; human; human cell; human embryonic stem cell; priority journal; protein cleavage; protein expression; tumor growth; tumor microenvironment; Western blotting; A-549 cell line; brain; brain tumor; cell communication; cell line; cell motion; drug effect; HEK293 cell line; human embryonic stem cell; nerve cell; organoid; pathology; physiology; tumor cell line ⓘ English 2020 2020-12 10.1096/fj.202000372r ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Anti-inflammatory Effect of Hydrolyzed Jujube Ethanolic Extract ⓘ ⓘ Kim, Yoonsu; Oh, Jisun; Kim, Jong-Sang ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol BK21PLUS, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.07063 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Attenuation of Scopolamine-Induced Learning and Memory Impairment by Ceriporia lacerata Mycelial Culture in C57BL/6 Mouse Model ⓘ ⓘ Lee, Sujin; Yun, Hyun; Oh, Jisun; Kim, Jong-Sang ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol BK21PLUS, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 4 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.07055 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Discovery and Quantitative Analysis of Nuclear Factor Erythroid 2-Related Factor (Nrf2) Activators in Maca (Lepidium meyenii) Using the Synthetic Macamides ⓘ ⓘ Hahn, Dongyup; Lee, Mijeong; Jeong, Hyeyoon; Kim, Jaewon; Kim, Minyoul ⓘ Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.09103 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Effects of [6]-Gingerol on β-amyloid-induced Cognitive Impairment in Mice ⓘ ⓘ Bae, Hui; Mun, Seul; Jang, Jung-Hee; Park, Gyu ⓘ Kyungpook Natl Univ, Daegu, South Korea; Keimyung Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.09101 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Ethanol Extract of Euonymus alatus Leaf Prevents Scopolamine-Induced Learning and Memory Impairment in Mice ⓘ ⓘ Woo, Yunju; Lim, Ji; Oh, Jisun; Kim, Jong-Sang ⓘ Kyungpook Natl Univ, BK21Plus Program, Sch Food Sci & Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-04 10.1096/fasebj.2020.34.s1.07305 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Exosomes co-expressing AQP5-targeting miRNAs and IL-4 receptor-binding peptide inhibit the migration of human breast cancer cells ⓘ Aquaporin-5 (AQP5) plays a role in breast cancer cell migration. This study aimed to identify AQP5-targeting miRNAs and examine their effects on breast cancer cell migration through exosome-mediated delivery. Bioinformatic analyses identified miR-1226-3p, miR-19a-3p, and miR-19b-3p as putative regulators of AQP5 mRNA. Immunoblotting revealed a decrease of AQP5 protein abundance when each of these miRNAs was transfected into human breast cancer MDA-MB-231 cells. Quantitative real-time PCR demonstrated the reduction of AQP5 mRNA expression by the transfection of miR-1226-3p and a luciferase reporter assay revealed the reduction of AQP5 translation after the transfection of miR-19b-3p in MDA-MB-231 cells. Consistently, the transfection of each miRNA impeded cell migration. Pathway enrichment analyses showed that these three miRNAs regulate target genes, which were predominantly enriched in the gap junction pathway. For the efficient delivery of AQP5-targeting miRNAs to breast cancer cells, exosomes expressing both miRNAs and a peptide targeting interleukin-4 receptor, which is highly expressed in breast cancer cells, were bioengineered and their inhibitory effects on AQP5 protein expression and cell migration were demonstrated in MDA-MB-231 cells. Taken together, AQP5-regulating miRNAs are identified, which could be exploited for the inhibition of breast cancer cell migration via the exosome-mediated delivery. ⓘ Park, Eui-Jung; Jung, Hyun Jun; Choi, Hyo-Jung; Jang, Hyo-Ju; Park, Hye-Jeong; Nejsum, Lene N.; Kwon, Tae-Hwan ⓘ Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Dongin Dong 101, Taegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Dept Biomed Sci, Sch Med, Taegu, South Korea; Johns Hopkins Univ, Sch Med, Dept Med, Div Nephrol, Baltimore, MD 21205 USA; Aarhus Univ, Dept Clin Med, Aarhus, Denmark ⓘ ; Jung, Hyun Jun/LKM-4480-2024; Park, Hye/C-1648-2013; PARK, EUIJUNG/LMO-3130-2024; Kwon, Tae-Hwan/ABA-1981-2020 ⓘ 50961544700; 36985354100; 56296381300; 57214330719; 57213039714; 57203420013; 7202206089 ⓘ thkwon@knu.ac.kr; ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 2 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 2.66 2025-06-25 ⓘ 48 49 aquaporin-5; breast cancer; cell migration; exosome; miRNA ⓘ INTERLEUKIN-4 RECEPTOR; TARGETED DELIVERY; AQUAPORIN-5; KIDNEY; SUPPRESSION; BIOGENESIS; SURVIVAL; GROWTH; SIRNA; AQP5 ⓘ aquaporin-5; breast cancer; cell migration; exosome; miRNA ⓘ Aquaporin 5; Breast Neoplasms; Cell Movement; Exosomes; Female; HEK293 Cells; Humans; Interleukin-4 Receptor alpha Subunit; MCF-7 Cells; MicroRNAs; Oligopeptides; aquaporin 5; binding protein; interleukin 4 receptor; interleukin 4 receptor binding peptide; messenger RNA; microRNA; microRNA 1226 3p; microRNA 19a 3p; microRNA 19b 3p; unclassified drug; AQP5 protein, human; aquaporin 5; IL4R protein, human; interleukin 4 receptor alpha; microRNA; oligopeptide; antineoplastic activity; Article; bioengineering; bioinformatics; breast cancer; cancer cell; cell migration; controlled study; embryo; exosome; gap junction; gene delivery system; genetic transfection; human; human cell; immunoblotting; intracellular signaling; luciferase assay; MCF-7 cell line; MDA-MB-231 cell line; migration inhibition; mRNA expression level; priority journal; protein expression; real time polymerase chain reaction; receptor binding; breast tumor; cell motion; exosome; female; genetics; HEK293 cell line; metabolism ⓘ English 2020 2020-02 10.1096/fj.201902434r ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions ⓘ Mitochondrial quality control maintains mitochondrial function by regulating mitochondrial dynamics and mitophagy. Despite the identification of mitochondrial quality control factors, little is known about the crucial regulators coordinating both mitochondrial fission and mitophagy. Through a cell-based functional screening assay, FK506 binding protein 8 (FKBP8) was identified to target microtubule-associated protein 1 light chain 3 (LC3) to the mitochondria and to change mitochondrial morphology. Microscopy analysis revealed that the formation of tubular and enlarged mitochondria was observed in FKBP8 knockdown HeLa cells and the cortex of Fkbp8 heterozygote-knockout mouse embryos. Under iron depletion-induced stress, FKBP8 was recruited to the site of mitochondrial division through budding and colocalized with LC3. FKBP8 was also found to be required for mitochondrial fragmentation and mitophagy under hypoxic stress. Conversely, FKBP8 overexpression induced mitochondrial fragmentation in HeLa cells, human fibroblasts and mouse embryo fibroblasts (MEFs), and this fragmentation occurred in Drp1 knockout MEF cells, FIP200 knockout HeLa cells and BNIP3/NIX double knockout HeLa cells, but not in Opa1 knockout MEFs. Interestingly, we found an LIR motif-like sequence (LIRL), as well as an LIR motif, at the N-terminus of FKBP8 and LIRL was essential for both inducing mitochondrial fragmentation and binding of FKBP8 to OPA1. Together, we suggest that FKBP8 plays an essential role in mitochondrial fragmentation through LIRL during mitophagy and this activity of FKBP8 together with LIR is required for mitophagy under stress conditions. ⓘ Yoo, Seung-Min; Yamashita, Shun-ichi; Kim, Hyunjoo; Na, DoHyeong; Lee, Haneul; Kim, Seo Jin; Cho, Dong-Hyung; Kanki, Tomotake; Jung, Yong-Keun ⓘ Seoul Natl Univ, Sch Biol Sci, 1 Gwanak Ro, Seoul 08826, South Korea; Niigata Univ, Grad Sch Med & Dent Sci, Dept Cellular Physiol, Niigata, Japan; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea ⓘ Lee, Jae/AAF-5113-2021; KIM, JIN/I-6927-2019; Kanki, Tomotake/H-7250-2012; Kim, Hyeonjin/M-3761-2019; Choi, Hye Rin/JDV-9065-2023 ⓘ 55837364400; 55417344100; 57212140284; 57214332757; 57204322071; 57214334032; 35093684400; 7006704933; 35358575000 ⓘ ykjung@snu.ac.kr; ⓘ FASEB JOURNAL ⓘ FASEB J ⓘ 0892-6638 1530-6860 34 2 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY ⓘ 2020 5.192 14.5 2.04 2025-06-25 ⓘ 57 57 FKBP8; mitochondria fission; mitophagy; OPA1; stress ⓘ AUTOPHAGOSOME FORMATION; CELL-DEATH; FISSION; DEGRADATION; PROTEIN; REQUIRES; PARKIN; DRP1; OPA1; RECRUITMENT ⓘ FKBP8; mitochondria fission; mitophagy; OPA1; stress ⓘ Animals; Fibroblasts; HEK293 Cells; HeLa Cells; Humans; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Dynamics; Stress, Physiological; Tacrolimus Binding Proteins; complementary DNA; fk 506 binding protein; fk 506 binding protein 8; microtubule associated protein; microtubule associated protein 1 light chain 3; protein; protein BNip3; protein drp1; protein nix; unclassified drug; fk 506 binding protein; FKBP8 protein, human; Fkbp8 protein, mouse; light chain 3, human; MAP1LC3 protein, mouse; microtubule associated protein; amino acid sequence; amino terminal sequence; animal cell; animal experiment; animal model; animal tissue; Article; cell hypoxia; cell stress; controlled study; embryo; female; fibroblast; HeLa cell line; heterozygote; human; human cell; iron depletion; ischemia; knockout mouse; LIR motif like sequence; mitochondrion; mitophagy; mouse; nonhuman; priority journal; protein binding; protein motif; protein protein interaction; screening; transmission electron microscopy; animal; genetics; HEK293 cell line; metabolism; mitochondrial dynamics; mitochondrion; physiological stress ⓘ English 2020 2020-02 10.1096/fj.201901735r ⓘ 바로가기 바로가기 바로가기 바로가기
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