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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Achieving Boosted Thermoelectric Power Factor of MoS2 through Selective Charged-Impurity-Free Doping ⓘ Ultrathin two-dimensional (2D) transition metal dichalcogenides (TMDs) exhibit unique band structures, allowing promising thermoelectric properties. Achieving a high power factor (PF) for thermoelectric generators (TEGs) requires optimizing both the Seebeck coefficient (S) and electrical conductivity (sigma). Conventional surface charge-transfer doping can be a solution to enhance sigma by introducing additional electrons. However, residual organic dopants act as charged impurities, degrading charge transport and lowering PF due to the intensified trade-off between carrier concentration and S. We propose a charged-impurity-free diffusion doping method for CVD-grown molybdenum disulfide (MoS2) to enhance PF. By depositing organic dopants on the contact region and enabling electron diffusion into the channel via carrier concentration gradients, sigma is improved while maintaining high S. This approach achieves a record-high PF of 1698 mu W/mK2 for CVD-grown TMDs. Our strategy offers a promising pathway to enhance thermoelectric performance, not limited by the exacerbated trade-off relationship observed in conventional doping methods. ⓘ Moon, Sooyeon; Yang, Jiwoo; Kwon, Deok Hwang; Cho, Daeheum; Kim, Jae-Keun; Shim, Jae Won; Kim, Heesuk; Lee, Takhee; Jang, Hyejin; Cho, Kyungjune; Chung, Seungjun ⓘ Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 08826, South Korea; Korea Univ, Sch Elect & Engn, Seoul 02841, South Korea; Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea; Korea Inst Sci & Technol, Ctr Energy Mat Res, Seoul 02792, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Max Planck Inst Microstruct Phys, D-06120 Halle, Saale, Germany; Korea Inst Sci & Technol, Elect & Hybrid Mat Res Ctr, Seoul 02792, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; Seoul Natl Univ, Inst Appl Phys, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Adv Mat, Seoul 08826, South Korea; Korea Inst Sci & Technol, Convergence Res Ctr Solut Electromagnet Interferen, Seoul 02792, South Korea ⓘ Kim, JaeKeun/KIE-2691-2024; Lee, Takhee/AAR-9632-2021; Jang, Hyejin/AFS-7402-2022 ⓘ 58084756200; 59300218500; 35976301400; 55263218400; 56800044700; 7201856264; 56166293500; 55731236400; 56992017200; 56956109300; 24069715700 ⓘ hjang@snu.ac.kr; kcho@kist.re.kr; seungjun@korea.ac.kr; ⓘ NANO LETTERS ⓘ NANO LETT ⓘ 1530-6984 1530-6992 25 25 SCIE CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2024 9.1 12.0 ⓘ 0 0 thermoelectric; 2D transition metal dichalcogenides; diffusion; charged-impurity-free doping; Seebeckcoefficient ⓘ THIN-FILMS; RANGE ⓘ 2D transition metal dichalcogenides; charged-impurity-free doping; diffusion; Seebeck coefficient; thermoelectric ⓘ Carrier concentration; Carrier transport; Doping (additives); Electric power factor; Electronic equipment; Impurities; Molybdenum compounds; Sulfur compounds; Thermoelectric equipment; Thermoelectric power; Charged impurity; Charged-impurity-free doping; Highpower-factor; MoS 2; Organic dopants; Seebeck; Thermoelectric; Transition metal dichalcogenides (TMD); Two-dimensional; Two-dimensional transition metal dichalcogenide; Diffusion; Economic and social effects; Seebeck coefficient ⓘ English 2025 2025-06-12 10.1021/acs.nanolett.5c01649 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Dose-Dependent Physiological Response to Transient Bioaccumulation of Tetracycline in Kimchi Cabbage (Brassica campestris L.) ⓘ Background/Objectives: Globally, antibiotic contamination has become an emerging issue in agricultural lands. The presence of antibiotic residues in farmlands, especially through the application of manure fertilizers containing veterinary antibiotics, e.g., tetracycline (TC), can cause severe toxicity, which inhibits crop growth and performance, subsequently threatening human health via consumption of contaminated products. This study was conducted to evaluate the phytotoxicity of TC on Kimchi cabbage (Brassica campestris L.) during seed germination, seedling, and vegetative growth stages, along with its physiological responses and bioaccumulation under TC stress. Methods: The responses of cabbage plants to TC stress were assessed through a germination test and a pot experiment, conducted for three days and six weeks, respectively, under different doses of TC (0, 5, 10, 25, and 50 mg/L). Results: As a result of the germination test, higher TC doses (25 and 50 mg/L) tended to delay seed germination, but all treatments achieved a 100% germination percentage by Day 3 after sowing. Eight days after sowing, the length of shoots and roots of seedlings exhibited a TC dose-dependent decline, specifically under 50 mg TC/L, showing a considerable decrease of 24% and 77%, respectively, compared to control. Similar results were observed in the plants transitioning from the seedling to vegetative stages in the pot experiment. Four and six weeks after sowing, the 50 mg TC/L dose showed the strongest phytotoxicity in cabbage plants with physiological parameters, such as the maximum photosystem II quantum yield (Fv/Fm), pigment content (chlorophyll and carotenoid), biomass, and leaf number, significantly reduced by 26 to 60% compared to control. Interestingly, at lower TC doses (5 and 10 mg/L), a hormesis effect was observed in the phenotype and biomass of the plants. In addition, the degree of TC accumulation in the plants was highly dose-dependent at Week 4 and Week 6, but a temporal decline in TC accumulation was noted between these time points in all TC treatments. This phenomenon might affect the value of the bio-concentration factor (BCF) as an indicator of the plant's tendency to uptake TC. That is, in Week 6, the dose-dependent reduction in BCF for TC in the plants was likely attributed to a dilution effect caused by plant biomass increase or a degradation mechanism within the plant. Conclusions: Overall, our findings suggest that tetracycline toxicity induces seed germination delay and influences seedling elongation and photosynthetic functions, ultimately impairing crop growth and performance. Also, the antibiotic dynamics related to accumulation and degradation in plants were identified. These results will not only suggest the toxicity threshold of TC for cabbage but also provide insights into effective soil management strategies for food production safety and agroecosystem sustainability in antibiotic-contaminated soils. ⓘ Chohra, Hadjer; Lee, Keum-Ah; Choe, Hyeonji; Cho, Ju Young; Kantharaj, Vimalraj; Cheong, Mi Sun; Kim, Young-Nam; Lee, Yong Bok ⓘ Gyeongsang Natl Univ, Div Appl Life Sci BK21 Four, Jinju 52828, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea; Kyungpook Natl Univ, Dept Crop Sci, Sangju 37224, South Korea ⓘ Kantharaj, Vimalraj/ITT-7462-2023; Kim, Young-Nam/J-7674-2016 ⓘ 57218376479; 57474839200; 57218370687; 58202402300; 57218372621; 59919229400; 56768489300; 59919420000 ⓘ chohra.hadjer@gnu.ac.kr; lka830815@gmail.com; youngnam.kim@knu.ac.kr; yblee@gnu.ac.kr; ⓘ ANTIBIOTICS-BASEL ⓘ ANTIBIOTICS-BASEL ⓘ 2079-6382 14 5 SCIE INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY ⓘ 2024 4.6 12.0 0 2025-06-11 ⓘ 0 0 veterinary antibiotic; phytotoxicity; tetracycline accumulation; crop performance; food safety ⓘ PERFORMANCE LIQUID-CHROMATOGRAPHY; VETERINARY ANTIBIOTICS; SEED-GERMINATION; SOIL; DEGRADATION; TOXICITY; GROWTH; RESIDUES; REMOVAL; LACCASE ⓘ crop performance; food safety; phytotoxicity; tetracycline accumulation; veterinary antibiotic ⓘ antibiotic resistance; Article; bioaccumulation; biomass; controlled study; electric conductivity; germination; high performance liquid chromatography; kimchi; liquid chromatography-mass spectrometry; microbial community; nonhuman; oilseed turnip; phenotype; physiological stress; physiology; phytotoxicity; relative humidity; seedling ⓘ English 2025 2025-05-13 10.3390/antibiotics14050501 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature-induced periodontitis in mice ⓘ BackgroundBacterial-induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.MethodsIn the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature-induced periodontitis in mice.ResultsGossypetin significantly reduced the differentiation of osteoclasts from mouse BMM precursors in the presence of the receptor activator of nuclear factor kappa B ligand (RANKL). In vitro, gossypetin inhibited critical signaling events downstream of RANKL including the auto-amplification of nuclear factor of activated T-cells, cytoplasmic 1, Ca2+ oscillations, and the generation of reactive oxygen species. In a mouse ligature-induced periodontitis model, the administration of gossypetin significantly reduced osteoclastogenesis and alveolar bone resorption. Furthermore, gossypetin prevented the ligature-induced increase in macrophages and T cells and reduced the production of tumor necrosis factor-alpha and interleukin-6.ConclusionTaken together, these results show anti-osteoclastogenic and anti-inflammatory effects of gossypetin, suggesting the potential use of this natural compound in periodontitis. ⓘ Seok, Jiwon; Kim, Myoung Ok; Kim, Sung-Hyun; Ryu, Ka-Young; Kim, Jae-Young; Lee, Heon-Jin; Kim, Yong-Gun; Lee, Youngkyun ⓘ Kyungpook Natl Univ, Sch Dent, Dept Biochem, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Coll Ecol & Environm Sci, Sangju, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Microbiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu 41940, South Korea ⓘ Kim, Yong-Gun/JPQ-3309-2023; Kim, Ji-Youn/A-5779-2017 ⓘ 58555739200; 8934745900; 59103241900; 57394631700; 56812734700; 36462383000; 55622694400; 36062942200 ⓘ ylee@knu.ac.kr; ⓘ JOURNAL OF PERIODONTOLOGY ⓘ J PERIODONTOL ⓘ 0022-3492 1943-3670 96 2 SCIE DENTISTRY, ORAL SURGERY & MEDICINE ⓘ 2024 3.8 12.0 0 2025-05-07 ⓘ 0 0 bone resorption; calcium; inflammation; osteoclasts; periodontitis ⓘ DISEASES; SEX; DIFFERENTIATION; RISK ⓘ bone resorption; calcium; inflammation; osteoclasts; periodontitis ⓘ Alveolar Bone Loss; Animals; Cell Differentiation; Disease Models, Animal; Flavonoids; Interleukin-6; Ligation; Macrophages; Male; Mice; Mice, Inbred C57BL; Osteoclasts; Periodontitis; RANK Ligand; Reactive Oxygen Species; acid phosphatase tartrate resistant isoenzyme; bromethol; calcium ion; cathepsin K; gossypetin; interleukin 6; osteoclast differentiation factor; reactive oxygen metabolite; tumor necrosis factor; flavonoid; gossypetin; interleukin 6; osteoclast differentiation factor; reactive oxygen metabolite; alveolar bone; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; bone marrow; bone volume fraction; chemoluminescence; controlled study; enzyme activity; fluorescence microscopy; gene expression; high performance liquid chromatography; histology; immunohistochemistry; in vitro study; in vivo study; inflammation; macrophage; male; micro-computed tomography; mouse; mRNA expression level; nonhuman; osteoclast; osteoclastogenesis; osteolysis; periodontitis; polyacrylamide gel electrophoresis; protein expression; real time polymerase chain reaction; T lymphocyte activation; Western blotting; alveolar bone loss; animal; C57BL mouse; cell differentiation; disease model; drug effect; drug therapy; ligation; metabolism; osteoclast; prevention and control ⓘ English 2025 2025-02 10.1002/jper.23-0541 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ H2S gas sensing properties of ZnO-SnO2 branch-stem nanowires grown on a copper foil ⓘ ZnO-SnO2 branch-stem nanowires were fabricated on a Cu foil using a chemical vapor deposition system through a two-step process. Firstly, SnO2 NWs were synthesized directly on a Cu foil substrate by evaporating SnO powder as a source material. Then, the as-synthesized SnO2 NWs were used as templates for the growth of ZnO-SnO2 branch-stem NWs. The effect of growth time on the growth of the SnO2 NWs on the Cu foil was studied. The gas sensing properties of the SnO2 NW and ZnO-SnO2 branch-stem NW devices were studied using various toxic gases at different temperatures. Both devices exhibited high sensitivity, high selectivity, fast response and recovery times, and stability toward H2S gas. Compared to the pristine SnO2 NW device, the ZnO-SnO2 branch-stem NW device exhibited higher sensitivity and faster response rate toward H2S. Finally, the gas sensing mechanism was also discussed. ⓘ Hung, Pham Tien; Thao, Dang Thi Huong; Hung, Nguyen Manh; Hoang, Nguyen Van; Hoat, Phung Dinh; Thin, Pham Van; Lee, Joon-Hyung; Heo, Young-Woo ⓘ Le Quy Don Tech Univ, Dept Phys, 236 Hoang Quoc Viet St, Hanoi 10000, Vietnam; Le Quy Don Tech Univ, Dept Mat Sci & Engn, 236 Hoang Quoc Viet St, Hanoi 10000, Vietnam; Kyungpook Natl Univ KNU, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Adv Mat Res Inst, Daegu 41566, South Korea ⓘ ; Hung, pham/ABF-3792-2021; Van Hoang, Nguyen/ABF-5601-2021; Hung, Nguyen/IUQ-1379-2023; Pham, Thin/ABG-1950-2021 ⓘ 57194216208; 57052998000; 57215027921; 57384227000; 57209732166; 59320804300; 57204923460; 7004298542 ⓘ ywheo@knu.ac.kr; ⓘ SCRIPTA MATERIALIA ⓘ SCRIPTA MATER ⓘ 1359-6462 1872-8456 255 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY ⓘ 2024 5.6 12.0 2.5 2025-05-07 ⓘ 2 2 ZnO-SnO2 branch-stem nanowire; H2S gas sensing; CVD method ⓘ SNO2 NANOWIRES; SENSORS; NANOFIBERS; FILM; FUNCTIONALIZATION; PERFORMANCES; CRYSTALLINE; SURFACE ⓘ CVD method; H<sub>2</sub>S gas sensing; ZnO–SnO<sub>2</sub> branch–stem nanowire ⓘ Chemical sensors; Gas sensing electrodes; Germanium compounds; Layered semiconductors; Nanowires; Photodissociation; Photoionization; Plasma enhanced chemical vapor deposition; Selenium compounds; Silicon compounds; Cu foil; CVD method; Gas sensing; Gas sensing properties; H2S gas sensing; High sensitivity; SnO 2; Synthesised; ZnO/SnO; ZnO–SnO2 branch–stem nanowire; Gas detectors ⓘ English 2025 2025-01-15 10.1016/j.scriptamat.2024.116372 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Pharmacodynamic Profiling of Amoxicillin: Targeting Multidrug-Resistant Gram-Positive Pathogens Staphylococcus aureus and Staphylococcus pseudintermedius in Canine Clinical Isolates ⓘ The rising threat of antimicrobial resistance (AMR) is a global concern in both human and veterinary medicine, with multidrug-resistant (MDR) pathogens such as Staphylococcus aureus and Staphylococcus pseudintermedius presenting significant challenges. Background/Objectives: This study evaluates the effectiveness of amoxicillin against these MDR pathogens in canine isolates using pharmacokinetic and pharmacodynamic parameters. Methods: Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and mutation prevention concentration (MPC) were assessed. Additionally, time-kill assays and post-antibiotic effect (PAE) assessments were performed. Epidemiological cutoff (ECOFF) values were established for both species to guide therapy. Results: S. aureus had a higher resistance rate (35.89%) than S. pseudintermedius (15.27%), with MIC50 values of 0.50 mu g/mL and 0.25 mu g/mL, respectively. The MPC analysis revealed that S. pseudintermedius required higher antibiotic concentrations (16.11 mu g/mL) to prevent mutations compared to S. aureus (2.20 mu g/mL). Time-kill assays indicated that higher amoxicillin dosages caused faster bacterial reduction. The PAE analysis showed extended post-treatment bacterial suppression at elevated doses, particularly against S. aureus. Conclusions: Species-specific amoxicillin dosing strategies are necessary due to differing resistance and susceptibility profiles between S. aureus and S. pseudintermedius. High-dose amoxicillin therapy is recommended to achieve optimal therapeutic outcomes for resistant SA, while slightly adjusted dosing can manage S. pseudintermedius infections. These findings provide essential insights for veterinary antimicrobial stewardship, underscoring the need for tailored therapeutic approaches to minimize AMR development while ensuring effective infection control. ⓘ Sayem, Syed Al Jawad; Lee, Ga-Yeong; Abbas, Muhammad Aleem; Park, Seung-Chun; Lee, Seung-Jin ⓘ Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea ⓘ ; Abbas, Muhammad Aleem/GLT-8362-2022; Park, Seung-Chun/AAV-3388-2021 ⓘ 57221340236; 58413330500; 57216531374; 7501832396; 58689440900 ⓘ aljawadsayem@knu.ac.kr; yeong1129@knu.ac.kr; syedaleemabbas77@gmail.com; parksch@knu.ac.kr; lee.seungjin@kitox.re.kr; ⓘ ANTIBIOTICS-BASEL ⓘ ANTIBIOTICS-BASEL ⓘ 2079-6382 14 1 SCIE INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY ⓘ 2024 4.6 12.0 0 2025-05-07 ⓘ 0 0 amoxicillin; Staphylococcus aureus; Staphylococcus pseudintermedius; minimal inhibitory concentration; time-kill assay; post-antibiotic effect ⓘ PETS; DOGS ⓘ amoxicillin; minimal inhibitory concentration; post-antibiotic effect; Staphylococcus aureus; Staphylococcus pseudintermedius; time-kill assay ⓘ amoxicillin; antimicrobial stewardship; Article; bacterial count; bacterial growth; bacterial load; bacterial suppression; bactericidal activity; bacterium culture; bacterium isolation; broth dilution; Canis; clinical effectiveness; clinical evaluation; colony forming unit; controlled study; disease severity assessment; epidemiological cutoff value; gene mutation; incubation time; limit of detection; linear regression analysis; logarithmic growth phase; MIC50; MIC90; minimum bactericidal concentration; minimum inhibitory concentration; multidrug resistant bacterium; mutation prevention concentration; nonhuman; pharmacodynamics; post antibiotic effect assessment; Staphylococcus aureus; Staphylococcus pseudintermedius; time dependent manner; time kill assay; two fold serial dilution ⓘ English 2025 2025-01 10.3390/antibiotics14010099 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Rapid Therapeutic Drug Monitoring of Voriconazole Based on High-Performance Liquid Chromatography: A Single-Center Pilot Study in Outpatients ⓘ Background/Objectives: Voriconazole (VRCZ) use requires accurate monitoring to avoid suboptimal drug levels and adverse effects. In addition, the appearance of resistant fungal strains is a problem that needs attention. Blood concentration measurement is the monitoring technique of choice; however, it is slow, limiting its clinical application. This study aimed to evaluate the clinical utility of rapid therapeutic drug monitoring (TDM) for VRCZ using high-performance liquid chromatography with ultraviolet detection (HPLC-UV) compared to conventional outsourced liquid chromatography–tandem mass spectrometry (LC-MS/MS) testing in outpatient care. Methods: VRCZ blood concentrations were measured using HPLC-UV and LC-MS/MS. Reporting times, accuracy, and clinical outcomes were assessed for outpatients receiving VRCZ treatment. Safety was monitored for renal, hepatic, and visual toxicities. Results: HPLC-UV significantly reduced reporting times (0.433 h vs. 74.3 h, p < 0.001), and Deming’s regression analyses showed a strong correlation with LC-MS/MS results (Pearson’s r = 0.988). Bland–Altman analysis showed an average difference of 0.025 μg/mL between HPLC-UV and LC-MS/MS. Prospective monitoring of three outpatients revealed no adverse events, enabling safe and effective VRCZ dosing. Conclusions: Rapid VRCZ TDM using HPLC-UV is a cost-effective and feasible approach for outpatient care, significantly improving reporting times and patient safety. Further studies and cross-facility collaboration are needed to expand its application. © 2025 by the authors. ⓘ Morikawa, Satoru; Yagi, Yusuke; Okazaki, Moemi; Yanagisawa, Narika; Ishida, Tomoaki; Jobu, Kohei; Maruyama, Takumi; Kato, Takahiro; Matsushita, Miyuki; Arakawa, Yu; Yamagishi, Yuka; Hamada, Yukihiro ⓘ Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea, Department of Chromatography Sales, Hitachi High-Tech Analysis Corporation, Tokyo, 105-6409, Japan; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea, Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, 783-8505, Japan; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea, Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, 783-8505, Japan; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea, Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, 783-8505, Japan; Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-0001, Japan; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea; Department of Chromatography Sales, Hitachi High-Tech Analysis Corporation, Tokyo, 105-6409, Japan; Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, 783-8505, Japan, Department of Clinical Infectious Diseases, Kochi Medical School, Kochi University, Kochi, 780-8072, Japan; Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, 783-8505, Japan, Department of Clinical Infectious Diseases, Kochi Medical School, Kochi University, Kochi, 780-8072, Japan; Department of Crop Science, Kyungpook National University, Sangju, 37224, South Korea ⓘ ⓘ 57208165526; 56178204900; 57203894311; 57210265572; 57204858954; 35753541900; 57462484700; 59919229300; 58166299900; 57220715148; 24779048500; 12760211300 ⓘ y.yamagishi@mac.com; ⓘ Antibiotics ⓘ ANTIBIOTICS-BASEL ⓘ 2079-6382 2079-6382 14 5 SCIE INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY ⓘ 2024 4.6 12.0 0 2025-06-11 ⓘ 0 ⓘ ⓘ adverse events; high-performance liquid chromatography; outpatient care; rapid therapeutic drug monitoring; voriconazole ⓘ alanine aminotransferase; alkaline phosphatase; voriconazole; adult; Article; blood level; blood sampling; chronic necrotizing pulmonary aspergillosis; clinical article; cost effectiveness analysis; drug monitoring; female; high performance liquid chromatography; human; liquid chromatography-mass spectrometry; male; middle aged; ophthalmologist; outpatient care; pilot study; quality control; visual impairment ⓘ English Final 2025 10.3390/antibiotics14050474 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Estimation of Optimal and Maximum Standardized Ileal Digestible Methionine Requirements Based on Performance for Male Broilers Aged 0 to 21 Days ⓘ Two experiments were conducted with Ross 308 male broiler chickens to determine the standardized ileal digestible (SID) methionine (Met) requirement for maximum weight gain during the starter (0 to 10 days) and grower (10 to 21 days) phases. A total of 720 and 288 birds were allocated to Experiments 1 and 2, respectively, and assigned six dietary treatments in a randomized complete block design. The experimental diets were formulated with corn, soybean meal, and synthetic amino acids to achieve varying SID Met levels (3.8 to 5.8 g/kg in experiment 1 and 3.0 to 5.5 g/kg in experiment 2), with increments of 0.4 and 0.5 g/kg. Weight gain, feed intake, and the gain-to-feed ratio (G:F) increased quadratically (p < 0.05) as dietary SID Met increased. The SID Met requirements for maximum weight gain and G:F in the starter phase were 5.1 g/kg (79.5 mg/d) and 5.3 g/kg (89.8 mg/d), while in the grower phase, they were 5.5 g/kg (343.0 mg/d) and 5.4 g/kg (330.3 mg/d), respectively. These findings, divided into two growth phases, provide guidelines to facilitate the optimal and maximum performance of young male broilers, and this may facilitate the selection of appropriate values for formulating broiler feed. These findings also highlight the importance of Met supplementation strategies for improving performance. ⓘ An, Su-Hyun; Kong, Changsu ⓘ Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea; Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea ⓘ ; 안, 수현/JFK-5079-2023 ⓘ 57216974969; 36027521600 ⓘ woobi89@gmail.com; changsukong@knu.ac.kr; ⓘ ANIMALS ⓘ ANIMALS-BASEL ⓘ 2076-2615 15 2 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 0 2025-05-07 ⓘ 1 1 amino acid requirement; methionine; standardized ileal digestible; broiler ⓘ AMINO-ACID REQUIREMENT; PLUS CYSTINE; LYSINE REQUIREMENT; PERIOD 3; GROWTH; CHICKS; DIETS; APPARENT ⓘ amino acid requirement; broiler; methionine; standardized ileal digestible ⓘ amino acid; cysteine; folic acid; lysine; methionine; threonine; valine; animal experiment; Article; artificial ventilation; body weight; body weight gain; broiler; chemical analysis; diet supplementation; digestion; food intake; gain to feed ratio; Gallus gallus; growth rate; ileum; male; nonhuman; practice guideline; relative humidity; soybean; soybean meal; thermoregulation ⓘ English 2025 2025-01 10.3390/ani15020278 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Genomic analysis of pESI-like megaplasmid in Salmonella Infantis from the poultry industry in Korea ⓘ The plasmid of emerging Salmonella Infantis (pESI) and pESI-like plasmids have been reported as a major cause of the dissemination of S. Infantis worldwide, and these plasmids have also been reported in Korea. In this study, eight pESI or pESI-like plasmids, including two pESI-like plasmids of S. Infantis from the poultry industry in Korea, harbored yersiniabactin operon, toxin/antitoxin systems, and fimbria clusters. Interestingly, various resistance genes were identified in the pESI-like plasmids but not in the pESI plasmid. In particular, dfrA14, which confers resistance to trimethoprim, was harbored in one copy in seven pESI or pESI-like plasmids, but the pM6-2-F5 plasmid harbored two copies. Additionally, the copy number of insertion sequence 26 in seven pESIlike plasmids was higher than in the pESI plasmid. In this study, 40 S. Infantis strains carrying the pESI or pESIlike plasmids from various countries, including two strains in Korea, were classified into two clusters, with the plasmids identified as IncI1 ST71 in cluster I and IncI1 ST209 in cluster II. The 16 strains representing IncI1 ST71 harbored blaCTX-M-65, whereas the 8 strains representing IncI1 ST209 harbored blaCTX-M-1. Our study provides valuable information on the pESI-like plasmid in S. Infantis from the poultry industry worldwide. ⓘ Kim, Min Beom; Lee, Young Ju ⓘ Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Daegu 41556, South Korea ⓘ ⓘ 58891566600; 59819261400 ⓘ minbum5935@gmail.com; youngju@knu.ac.kr; ⓘ VETERINARY MICROBIOLOGY ⓘ VET MICROBIOL ⓘ 0378-1135 1873-2542 307 SCIE MICROBIOLOGY;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 N/A ⓘ 0 0 PESI-like plasmid; Poultry industry; Whole genome sequencing; Antimicrobial resistance ⓘ ⓘ Antimicrobial resistance; PESI-like plasmid; Poultry industry; S. Infantis; Whole genome sequencing ⓘ ampicillin; cefazolin; cefotaxime; ceftriaxone; cefuroxime; chloramphenicol; genomic DNA; gentamicin; nalidixic acid; tetracycline; trimethoprim; yersiniabactin; antibiotic resistome; Article; bacterial gene; bacterial strain; blaCTX M 1 gene; blaCTX M 65 gene; controlled study; dfrA14 gene; fimbria; gene insertion sequence; nonhuman; operon; plasmid; poultry; Salmonella enterica serovar Infantis; South Korea; toxin-antitoxin system; trimethoprim resistance; whole genome sequencing ⓘ English 2025 2025-08 10.1016/j.vetmic.2025.110576 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Molecular Epidemiology of Coxiella burnetii in Boer Goats and Their Farm Environment in South Korea with a One Health Approach ⓘ Q fever, caused by Coxiella burnetii, is a zoonotic disease that poses significant risks to both livestock productivity and human health. This is the first molecular and epidemiological study of C. burnetii infections on a Boer goat farm in South Korea, encompassing clinical cases in animals and humans, as well as environmental contamination. The investigation was initiated following abortion cases at a farm that co-raised Boer goats and cattle. Samples-including vaginal swabs, aborted fetuses, blood, tissues, feces, dust, and soil-were tested using PCR, confirming C. burnetii infection from multiple sources. Genotyping through Multiple Locus Variable Number Tandem Repeat Analysis and Multispacer Sequence Typing revealed molecular epidemiological links between farm-detected strains and those previously identified in human cases from South Korea, France, and the UK, suggesting possible zoonotic transmission. C. burnetii was also found in dust, soil, feces, and in farmworkers, indicating ongoing environmental and occupational exposure. These findings emphasize the role of environmental contamination in disease persistence and the need for improved biosecurity and coordinated surveillance. This study supports a One Health approach and offers meaningful implications for public health policy, particularly in establishing effective strategies for monitoring and controlling Q fever in livestock farms and surrounding communities. ⓘ Lee, You-Jeong; Kim, Beoul; Kang, Yong-Myung; Kwak, Dongmi; Seo, Min-Goo ⓘ Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, 80 Daehak Ro,Buk Gu, Daegu 41566, South Korea ⓘ Seo, Min-Goo/NQF-4335-2025 ⓘ 59343760600; 59343608800; 59702372200; 7007148758; 58950739700 ⓘ wowgirlsgood@naver.com; kbjjhnm@naver.com; kamaboy88@knu.ac.kr; dmkwak@knu.ac.kr; koreasmg@knu.ac.kr; ⓘ ANIMALS ⓘ ANIMALS-BASEL ⓘ 2076-2615 15 10 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 N/A ⓘ 0 0 boer goat; Coxiella burnetii; clinical case; environmental contamination; one health ⓘ Q-FEVER; INFECTION; SHEEP ⓘ boer goat; clinical case; Coxiella burnetii; environmental contamination; one health ⓘ adult; aged; Article; biosecurity; Brucella abortus; Campylobacter jejuni; Coxiella burnetii; DNA extraction; DNA sequencing; dust; female; genotype; genotyping; health care policy; human; Listeria encephalitis; livestock; One Health; phylogeny; Q fever; Salmonella enterica serovar Dublin; South Korea; Toxoplasma gondii; zoonosis; zoonotic transmission ⓘ English 2025 2025-05-21 10.3390/ani15101498 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Nationwide Geographical and Temporal Distribution of Tick-Borne Diseases in Korean Water Deer (Hydropotes inermis argyropus) ⓘ Ticks are major vectors of numerous pathogens, and their public health significance is increasing due to climate change and the expanding involvement of wildlife hosts. In Korea, the Korean water deer (KWD, Hydropotes inermis argyropus) is widely distributed and considered a key wild host for ticks, potentially serving as a reservoir for diverse tick-borne diseases (TBDs). To examine the geographical and temporal distribution of TBDs in this species, 1035 spleen samples were collected from KWDs across 12 regions between April and November 2023. Overall, 93.6% (969) of samples were positive for at least one pathogen. Five Anaplasma species were identified: A. phagocytophilum, A. phagocytophilum-like A (APLA), APLB, A. bovis, and A. capra. In addition, Borrelia theileri and three Theileria species-T. capreoli, T. cervi, and T. luwenshuni-were detected. Notably, this study presents the first global detection of APLA, APLB, and B. theileri in KWDs. Statistically significant regional and seasonal differences in prevalence were observed, with higher detection rates in northern regions and during autumn, suggesting that environmental and ecological factors influence transmission dynamics. These findings highlight the role of KWD as a reservoir host for multiple TBDs and underscore the importance of wildlife-based surveillance for assessing zoonotic disease risks. ⓘ Kim, Beoul; Chae, Su-Jin; Lee, You-Jeong; Shin, Haksub; Kwak, Sunmin; Jeong, Hyesung; Lee, Suwoong; Kwak, Dongmi; Seo, Min-Goo ⓘ Kyungpook Natl Univ, Coll Vet Med, Inst Vet Biomed Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, 80 Daehak Ro, Daegu 41566, South Korea; Natl Inst Wildlife Dis Control & Prevent, Wildlife Dis Res Team, 1 Songam Gil, Gwangju 62407, South Korea ⓘ Seo, Min-Goo/NQF-4335-2025 ⓘ 59343608800; 35744581100; 59343760600; 59919496900; 59920227100; 57213935791; 59415517000; 7007148758; 58950739700 ⓘ kbjjhnm@naver.com; chsj1215@korea.kr; wowgirlsgood@naver.com; tgs00089@korea.kr; sunmin3416@naver.com; halley@korea.kr; hoffman@korea.kr; dmkwak@knu.ac.kr; koreasmg@knu.ac.kr; ⓘ ANIMALS ⓘ ANIMALS-BASEL ⓘ 2076-2615 15 10 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 0 2025-06-11 ⓘ 0 0 tick-borne diseases; Korean water deer; Anaplasma spp.; Borrelia spp.; Theileria spp. ⓘ CERVUS-NIPPON-YESOENSIS; ANAPLASMA-PHAGOCYTOPHILUM; MOLECULAR-DETECTION; INFECTION; THEILERIA; BOVIS; HOKKAIDO; CATTLE; SPP.; IDENTIFICATION ⓘ Anaplasmaspp; Borreliaspp; Korean water deer; Theileriaspp; tick-borne diseases ⓘ accuracy; algorithm; Anaplasma phagocytophilum; animal experiment; animal tissue; Article; Borrelia; Borrelia theileri; density; disease control; dynamics; gene expression; nonhuman; phylogenetic tree; phylogeny; public health; real time polymerase chain reaction; tick borne disease; transmission dynamics; water deer; zoonosis ⓘ English 2025 2025-05-21 10.3390/ani15101499 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Tension-sensitive HOX gene expression in fibroblasts for differential scar formation ⓘ BackgroundScar formation is a common end-point of the wound healing process, but its mechanisms, particularly in relation to abnormal scars such as hypertrophic scars and keloids, remain not fully understood. This study unveils a novel mechanistic insight into scar formation by examining the differential expression of Homeobox (HOX) genes in response to mechanical forces in fibroblasts derived from normal skin, hypertrophic scars, and keloids.MethodsWe isolated fibroblasts from different scar types and conducted RNA sequencing (RNA-Seq) to identify differential gene expression patterns among the fibroblasts. Computational modeling provided insight into tension alterations following injury, and these findings were complemented by in vitro experiments where fibroblasts were subjected to exogenous tensile stress to investigate the link between mechanical tension and cellular behavior.ResultsOur study revealed differential HOX gene expression among fibroblasts derived from normal skin, hypertrophic scars, and keloids. Computational simulations predicted injury-induced tension reduction in the skin, and in vitro experiments revealed a negative correlation between tension and fibroblast proliferation. Importantly, we discovered that applying mechanical tension to fibroblasts can modulate HOX gene expression, suggesting a pivotal role of mechanical cues in scar formation and wound healing.ConclusionThis study proposes a model wherein successful wound healing and scar formation are critically dependent on maintaining tensional homeostasis in the skin, mediated by tension-sensitive HOX genes. Our findings highlight the potential of targeting mechanotransduction pathways and tension-sensitive HOX gene expression as therapeutic strategies for abnormal scar prevention and treatment, offering a new perspective on the complex process of scar formation. ⓘ Kang, Minwoo; Ko, Ung Hyun; Oh, Eun Jung; Kim, Hyun Mi; Chung, Ho Yun; Shin, Jennifer H. ⓘ Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, CMRI, Daegu, South Korea ⓘ Kang, Min-woo/AAJ-5405-2020; 오, 은정/GSO-2090-2022 ⓘ 58037994600; 55588876700; 35746789300; 57261065200; 7404007181; 7402724017 ⓘ j_shin@kaist.ac.kr; ⓘ JOURNAL OF TRANSLATIONAL MEDICINE ⓘ J TRANSL MED ⓘ 1479-5876 23 1 SCIE MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2024 7.5 12.1 0 2025-05-07 ⓘ 0 0 Scar formation; Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Tensional homeostasis; HOX genes; Postnatal morphogenesis ⓘ HYPERTROPHIC SCARS; COLLAGEN PRODUCTION; DERMAL FIBROBLASTS; CYCLIC STRETCH; WOUND REPAIR; RISK-FACTORS; SKIN; CELL; KELOIDS; PROLIFERATION ⓘ HOX genes; Hypertrophic scar; Keloid; Postnatal morphogenesis; Scar formation; Tension; Tension change; Tensional homeostasis; Wound healing ⓘ Cell Proliferation; Cicatrix; Cicatrix, Hypertrophic; Computer Simulation; Fibroblasts; Gene Expression Regulation; Genes, Homeobox; Homeodomain Proteins; Humans; Keloid; Skin; Stress, Mechanical; Wound Healing; alpha smooth muscle actin; collagen type I alpha 1 chain; Hox protein; Ki 67 antigen; transcription factor HoxA9; homeodomain protein; Article; cell isolation; differential gene expression; fibroblast; finite element analysis; gene expression; gene ontology; homeobox; Hox gene; human; human cell; human tissue; hypertrophic scar; keloid; mechanotransduction; morphogenesis; RNA sequencing; scar formation; scar tissue; wound healing; cell proliferation; computer simulation; gene expression regulation; genetics; homeobox; keloid; mechanical stress; metabolism; pathology; scar; skin ⓘ English 2025 2025-02-10 10.1186/s12967-025-06191-1 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The Effect of Poppy Oil on Egg Production and Calcium Metabolism in Japanese Quail ⓘ Consumers tend to favor natural dietary supplements to improve their health. However, vendors rarely cite scientific evidence to justify these claims. In the case of poppy oil, it is often mentioned as having a positive effect on Ca metabolism-related disorders, but no proof has been provided. Therefore, the aim of our trial was to test the possible effect of poppy oil on calcium metabolism using Japanese quail layers as a model animal. A total of 120 four-week-old quail were divided into three dietary treatments (four cages per treatment, with ten birds in each cage): a control group (using sunflower oil as the energy source in the diet), 0.5%, and 1% poppy oil supplementation (replacing sunflower oil). Egg production, eggshell thickness, eggshell strength, and egg yolk color were investigated. Ca retention was determined using the acid-insoluble ash method. At the end of the experiment, two birds per cage were sacrificed, and uterus and jejunum samples were collected for gene expression analyses. Poppy oil supplementation improved egg production in terms of intensity, egg weight, and eggmass production. The thickness and eggshell strength decreased when 1% poppy oil was fed to the animals, while Ca retention improved. Poppy oil supplementation increased the expression of Ca transporter genes (CALB1, SLC8A1, and SLC26A9) in the uterus and ITPR1 in the jejunum. Our results indicate a possible effect of poppy oil on Ca metabolism. Further studies are needed to identify the active compound and to understand the mode of action. ⓘ Szabo, Csaba; Ozsvath, Xenia; Csernus, Brigitta; Gulyas, Gabriella; Horvath, Marta; Czegledi, Levente; Olah, Janos; Rizqoh, Nafiatur; Achille, Gabriele; Posta, Janos ⓘ Univ Debrecen, Fac Agr & Food Sci & Environm Management, Dept Anim Nutr & Physiol, H-4032 Debrecen, Hungary; Univ Debrecen, Fac Agr & Food Sci & Environm Management, Dept Anim Husb, H-4032 Debrecen, Hungary; Univ Debrecen, Fac Sci & Technol, Dept Evolutionary Zool & Human Biol, H-4032 Debrecen, Hungary; Univ Debrecen, Inst Agr Res & Educ Farm, Kismacs Expt Stn Anim Husb, H-4032 Debrecen, Hungary; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Univ Macerata, Lab Protistol & Biol Educ, I-62100 Macerata, Italy ⓘ Czeglédi, Levente/AFV-9121-2022; Gulyás, Gabriella/ISU-5458-2023; Csernus, Brigitta/HMP-7624-2023 ⓘ 55702519363; 57215092637; 57215085806; 56708326400; 57200882993; 6503953869; 57195638472; 59904310100; 58030285000; 16234781900 ⓘ szabo.csaba@agr.unideb.hu; xenia.ozsvath@gmail.com; csernusb@science.unideb.hu; gulyas@agr.unideb.hu; mhorvath@agr.unideb.hu; czegledi@agr.unideb.hu; olahja@agr.unideb.hu; nafiatur.rizqoh279@gmail.com; g.achille@unimc.it; postaj@agr.unideb.hu; ⓘ ANIMALS ⓘ ANIMALS-BASEL ⓘ 2076-2615 15 9 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 0 2025-06-11 ⓘ 0 0 poppy oil; egg production; egg quality; calcium; Japanese quail ⓘ FATTY-ACID-COMPOSITION; QUALITY PARAMETERS; LAYING HENS; SEED; PERFORMANCE; PHOSPHORUS; JAPONICA; PROFILE; YOLK ⓘ calcium; egg production; egg quality; Japanese quail; poppy oil ⓘ edible oil; poppy oil; sunflower oil; unclassified drug; animal experiment; animal tissue; Article; CALB1 gene; calcium metabolism; controlled study; egg production; egg weight; eggshell strength; eggshell thickness; gene; gene expression; japanese ouail; mRNA expression level; nonhuman; quail; SLC26A9 gene; SLC8A1 gene ⓘ English 2025 2025-05-07 10.3390/ani15091348 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The Effects of Human-Horse Interactions on Oxytocin and Cortisol Levels in Humans and Horses ⓘ Therapeutic programs involving human-horse interactions are gaining popularity as a means of enhancing human well-being. Understanding the physiological responses of both humans and horses during these interactions is essential for evaluating the effectiveness of such programs. This study examined the effects of specific interactive activities on both humans and horses by monitoring changes in oxytocin and cortisol levels. Six participants and six horses took part in the study. The participants engaged in three distinct activities, each lasting 15 min: (1) resting alone without the horse (resting), (2) standing near the horse without physical contact (standing), and (3) gently rubbing the horse's neck and withers (rubbing). Saliva samples from the participants and blood samples from the horses were collected at three time points for each activity: T0 (before the activity), T1 (at the end of the activity), and T2 (15 min after the activity ended). The results indicated that oxytocin levels significantly increased in horses at T2 following both the standing and rubbing activities, while cortisol levels remained unchanged in both humans and horses across all activities. These findings suggest that human-horse interactions, particularly standing and rubbing, may foster social bonding in horses without eliciting a stress response in either species. ⓘ Jung, Youngwook; Yoon, Minjung ⓘ Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea ⓘ ⓘ 57219279028; 22137296500 ⓘ wook02070@gmail.com; mjyoonemail@gmail.com; ⓘ ANIMALS ⓘ ANIMALS-BASEL ⓘ 2076-2615 15 7 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES ⓘ 2024 2.7 12.1 0 2025-05-07 ⓘ 0 0 human; equine; social interaction; stress response; saliva oxytocin; plasma oxytocin; saliva cortisol; plasma cortisol ⓘ ANIMAL-ASSISTED THERAPY; HEART-RATE-VARIABILITY; DOG-HUMAN; STRESS; RESPONSES; DISORDER; EXERCISE; BEHAVIOR; SYSTEM ⓘ equine; human; plasma cortisol; plasma oxytocin; saliva cortisol; saliva oxytocin; social interaction; stress response ⓘ edetic acid; hydrocortisone; oxytocin; adult; animal experiment; Article; blood sampling; centrifugation; conditioning (psychology); enzyme linked immunosorbent assay; female; horse; human; male; nonhuman; physiological stress; saliva; wellbeing ⓘ English 2025 2025-03-21 10.3390/ani15070905 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ High-resolution mass spectrometry characterization of secondary organic aerosol formation: Comparative effects of NH3 on biotic and abiotic precursors ⓘ This study explores the role of ammonia (NH3) in the formation of nitrogen-containing secondary organic aerosol (SOA) using smog chamber experiments. Reactive organic gases, including toluene, m-xylene, ethylbenzene, alpha-pinene, and isoprene, were analyzed under NH3-present and NH3-absent conditions. High resolution mass spectrometry revealed that toluene, m-xylene, ethylbenzene and isoprene exhibited higher signal-to-noise (S/N) ratios and an increased abundance of nitrogen-containing oxygenated compounds in the presence of NH3. Conversely, alpha-PIN demonstrated high S/N ratios in both conditions, though CHON formation increased with NH3, emphasizing its role in nitrogen incorporation into SOA. The study also identified low-volatility, highly oxidized compounds with double-bond equivalent values exceeding 5, along with oligomeric structures that contribute to particulate matter growth. Mechanistic analysis showed that CHON compounds are formed through photooxidation pathways involving hydroxyl radical reactions, oxidation, nitration, and hydrolysis, consistent with mass spectrometry data. These findings underscore the critical role of NH3 in modifying SOA composition and highlight its potential implications for atmospheric particulate matter formation and air quality. ⓘ Park, Geondo; Lee, Seong Weon; Ali, Ahsan; Dao, Pham Duy Quang; Cho, Chan Sik; Lim, Ho-Jin; Kim, Sunghwan ⓘ Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Vietnam Acad Sci & Technol, Inst Appl Mat Sci, Ho Chi Minh City 700000, Vietnam ⓘ ⓘ 57932478900; 57737643600; 58155521500; 57224992193; 7403100019; 56883100200; 57203772967 ⓘ sunghwank@knu.ac.kr; ⓘ ENVIRONMENTAL POLLUTION ⓘ ENVIRON POLLUT ⓘ 0269-7491 1873-6424 380 SCIE ENVIRONMENTAL SCIENCES ⓘ 2024 7.3 12.2 0 2025-06-11 ⓘ 0 0 Secondary organic aerosol (SOA); Ammonia (NH 3 ); High resolution mass spectrometry; Oligomer; Volatility; Photooxidation pathway ⓘ PARTICLE FORMATION; OLIGOMER FORMATION; PHOTOOXIDATION; OZONOLYSIS; SO2; CHEMISTRY; KINETICS; SULFUR; NOX; ORGANOSULFATES ⓘ Ammonia (NH<sub>3</sub>); High resolution mass spectrometry; Oligomer; Photooxidation pathway; Secondary organic aerosol (SOA); Volatility ⓘ Aerosols; Air Pollutants; Ammonia; Benzene Derivatives; Bicyclic Monoterpenes; Butadienes; Environmental Monitoring; Hemiterpenes; Mass Spectrometry; Pentanes; Xylenes; Ammonia; acetonitrile; ammonia; cresol; dichloromethane; hydroxyl radical; nitrogen; oxygen radical; xylene; 1,3 butadiene derivative; alpha-pinene; benzene derivative; bicyclic monoterpenoid; ethylbenzene; hemiterpene; isoprene; pentane; xylene; Ammonia (NH3); Condition; High resolution mass spectrometry; High signal-to-noise ratio; m-Xylene; NH 3; Organic aerosol; Photooxidation pathway; Secondary organic aerosol; Volatility; abiotic factor; aerosol formation; ammonia; biotic factor; comparative study; mass spectrometry; photooxidation; polymer; aerosol; air quality; amidation; Article; atmosphere; controlled study; electrospray mass spectrometry; enthalpy; flow rate; lipid peroxidation; mass spectrometry; nitration; nonhuman; oxidation; particulate matter; photooxidation; reduction (chemistry); secondary organic aerosol; signal noise ratio; solvent extraction; sulfonation; thermodynamics; volatility based chromatography; aerosol; air pollutant; chemistry; comparative study; environmental monitoring; mass spectrometry; Photooxidation ⓘ English 2025 2025-09-01 10.1016/j.envpol.2025.126526 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Piecewise physics-informed neural networks for surrogate modelling of non-smooth system in elasticity problems using domain decomposition ⓘ To interpret physical phenomena, traditional mesh-based methods, such as finite element method, have proven effective for engineering problems. However, as system complexity increases, whether due to larger scales, finer resolutions, or intricate geometries, these methods face significant limitations in term of computational cost and time. Complex problems, particularly those involving irregular boundaries or nonlinear behaviour, require finer meshes and greater computational power, making real-time analysis difficult. This challenge is especially relevant in agricultural systems, which are subject to high uncertainty and constantly changing environmental conditions. In this study, we proposed a method referred to as piecewise physics-informed neural networks (PINNs) to solve non-smooth problems in structural mechanics using neural networks by decomposing the computational domain. To quantitatively evaluate the performance of this method, three representative structural mechanics problems with non-smooth characteristics are employed. Results demonstrated that the piece- wise PINNs provided more accurate solutions compared to conventional PINNs on these benchmark problems. Additionally, we developed a surrogate model for the non-smooth problems using piecewise PINNs without any labelled data and compared it with a model trained using deep neural networks. The proposed model outperformed the deep neural network model in cases of plane-stress problem. The results also showed that the surrogate model trained with piecewise PINNs exhibited an advantage in terms of execution time over the finite element analysis software. ⓘ Jeong, Youngjoon; Lee, Sangik; Lee, Jong-hyuk; Choi, Won ⓘ Seoul Natl Univ, Grad Sch Data Sci, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Coll Agr & Life Sci, Dept Landscape Architecture & Rural Syst Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Landscape Architecture & Rural Syst Engn, Integrated Major Global Smart Farm,Coll Agr & Life, 1 Gwanak Ro, Seoul 08826, South Korea ⓘ Lee, Sangik/JFS-3290-2023; Lee, Jong-Hyuk/HTQ-9685-2023 ⓘ 57218213405; 57218215209; 57221623269; 54412025900 ⓘ fembem@snu.ac.kr; ⓘ BIOSYSTEMS ENGINEERING ⓘ BIOSYST ENG ⓘ 1537-5110 1537-5129 251 SCIE AGRICULTURAL ENGINEERING;AGRICULTURE, MULTIDISCIPLINARY ⓘ 2024 5.3 12.2 0 2025-05-07 ⓘ 0 1 Surrogate modelling; Physics-informed neural networks; Domain decomposition; Structural mechanics; Interface problems ⓘ DEEP LEARNING FRAMEWORK ⓘ Domain decomposition; Interface problems; Physics-informed neural networks; Structural mechanics; Surrogate modelling ⓘ Pressure vessels; Domain decompositions; Elasticity problems; Interface problems; Neural-networks; Nonsmooth systems; Physic-informed neural network; Physical phenomena; Piece-wise; Structural mechanics; Surrogate modeling; Mesh generation ⓘ English 2025 2025-03 10.1016/j.biosystemseng.2025.01.017 ⓘ 바로가기 바로가기 바로가기 바로가기
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