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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | T-DXd vs TPC in patients with HER2-low unresectable and/or metastatic BC in Asian subgroup: Results of DESTINY-Breast04 | Tsurutani, Junji; Modi, Shanu; Sohn, Joo Hyuk; Tokunaga, Eriko; Niikura, Naoki; Park, Yeon Hee; Lee, Keun Seok; Chae, Yee Soo; Wang, Xiaojia; Li, Wei; Im, Seock-Ah; Xu, Binghe; Lu, Yen-Shen; Gambhire, Dhiraj; Nishijima, Soichiro; Nishiyama, Yuji; Sugihara, Masahiro | Showa Univ, Adv Canc Translat Res Inst, Tokyo, Japan; Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA; Yonsei Canc Ctr, Seoul, South Korea; Natl Hosp Org Kyushu Canc Ctr, Fukuoka, Japan; Tokai Univ, Hiratsuka, Kanagawa, Japan; Samsung Med Ctr, Seoul, South Korea; Natl Canc Ctr, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou, Peoples R China; Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China; 1st Hosp Jilin Univ, Changchun, Peoples R China; Seoul Natl Univ Hosp, Seoul, South Korea; CAMS, Canc Inst & Hosp, Beijing, Peoples R China; Natl Taiwan Univ Hosp, Taipei, Taiwan; Daiichi Sankyo Inc, Basking Ridge, NJ USA; Daiichi Sankyo Co Ltd, Tokyo, Japan; Kanagawa Canc Ctr, Yokohama, Kanagawa, Japan | Shen, Yuchen/AAO-4015-2020; Nishijima, Soichiro/KVA-8556-2024; Im, Seock-Ah/J-5620-2012 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 34 | SCIE | ONCOLOGY | 2023 | 56.7 | 1.1 | 0 | English | 2023 | 2023-11 | 10.1016/j.annonc.2023.09.106 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | The expression of proteins associated with iron metabolism in the human placenta complicated with preeclampsia | Kim, Haemin; Kim, Hyo-shin; Kim, Hyun Mi; Kim, Mi Ju; Cha, Hyun-Hwa; Seong, Won Joon | Kyungpook Natl Univ Hosp, Daegu, Taegu Jikhalsi, South Korea | Kim, Soo/P-7880-2016; Kim, Mi Ju/HGU-8470-2022; Kim, Young-Il/ISS-7678-2023 | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | AM J OBSTET GYNECOL | 0002-9378 | 1097-6868 | 228 | 1 | SCIE | OBSTETRICS & GYNECOLOGY | 2023 | 8.7 | 1.1 | 0 | English | 2023 | 2023-01 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng | Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective method, called the ginpolin protocol, to separate gintonin-enriched fraction (GEF), ginseng polysaccharide fraction (GPF), and crude ginseng saponin fraction (cGSF).Methods: Dried ginseng (1 kg) was extracted using 70% ethanol (EtOH). The extract was water frac-tionated to obtain a water-insoluble precipitate (GEF). The upper layer after GEF separation was precipitated with 80% EtOH for GPF preparation, and the remaining upper layer was vacuum dried to obtain cGSF.Results: The yields of GEF, GPF, and cGSF were 14.8, 54.2, and 185.3 g, respectively, from 333 g EtOH extract. We quantified the active ingredients of 3 fractions: L-arginine, galacturonic acid, ginsenosides, glucuronic acid, lysophosphatidic acid (LPA), phosphatidic acid (PA), and polyphenols. The order of the LPA, PA, and polyphenol content was GEF > cGSF > GPF. The order of L-arginine and galacturonic acid was GPF >> GEF = cGSF. Interestingly, GEF contained a high amount of ginsenoside Rb1, whereas cGSF contained more ginsenoside Rg1. GEF and cGSF, but not GPF, induced intracellular [Ca2 thorn ]i transient with antiplatelet activity. The order of antioxidant activity was GPF > GEF = cGSF. Immunological activities (related to nitric oxide production, phagocytosis, and IL-6 and TNF-a release) were, in order, GPF > GEF = cGSF. The neuroprotective ability (against reactive oxygen species) order was GEF > cGSP > GPF.Conclusion: We developed a novel ginpolin protocol to isolate 3 fractions in batches and determined that each fraction has distinct biological effects.(c) 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lee, Rami; Cho, Han -Sung; Kim, Ji -Hun; Cho, Hee -Jung; Choi, Sun-Hye; Hwang, Sung -Hee; Rhim, Hyewon; Cho, Ik-Hyun; Rhee, Man -Hee; Kim, Do-Geun; Kim, Hyoung-Chun; Nah, Seung-Yeol | Konkuk Univ, Coll Vet Med, Dept Physiol, Ginsentol Res Lab, Seoul, South Korea; Sangji Univ, Coll Hlth Sci, Dept Pharmaceut Engn, Wonju, South Korea; Korea Inst Sci & Technol, Ctr Neurosci, Seoul, South Korea; Kyung Hee Univ, Grad Sch, Dept Convergence Med Sci, Dept Sci Korean Med, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Lab Physiol & Cell Signalling, Daegu, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu, South Korea; Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon, South Korea; Konkuk Univ, Coll Vet Med, Dept Physiol, Ginsentol Res Lab, Seoul 05029, South Korea | Cho, Young Hye/AEJ-4099-2022; Cho, Ik-Hyun/A-9348-2014; Rhee, Man/O-5705-2016 | 57034602100; 57222196783; 57989216500; 57206270423; 22133433200; 57034594000; 7006154214; 7102561903; 57211035357; 55797863700; 36065569300; 7005224178 | rmlee12@konkuk.ac.kr;newlove0202@nate.com;bioskjh@naver.com;ouddi80@naver.com;vettman@naver.com;sunghhwang@sangji.ac.kr;hrhim@kist.re.kr;ihcho@khu.ac.kr;rheemh@knu.ac.kr;kimvet0911@kbri.re.kr;kimhc@kangwon.ac.kr;synah@konkuk.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 47 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2023 | 6.8 | 1.2 | 0.59 | 2025-06-25 | 4 | 3 | Ginseng; Ginsenoside; Gintonin; Ginseng polysaccharide; Batch separation | COLORIMETRIC METHOD; ACTIVATION; SAPONINS; PATHWAY; GROWTH | Batch separation; Ginseng; Ginseng polysaccharide; Ginsenoside; Gintonin | alcohol; arginine; calcium ion; galacturonic acid; ginsenoside; ginsenoside Rb 1; gintonin; glucuronic acid; interleukin 6; lysophosphatidic acid; nitric oxide; phosphatidic acid; polyphenol; polysaccharide; saponin; tumor necrosis factor; unclassified drug; animal cell; animal experiment; antioxidant activity; antiplatelet activity; Article; chemical composition; controlled study; cytokine release; drug isolation; extraction; fractionation; ginseng; intracellular space; nonhuman; phagocytosis; precipitation; rat; thrombocyte aggregation | English | 2023 | 2023-05 | 10.1016/j.jgr.2022.10.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets | Background and objective: The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) and ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, and Ro. Among these compounds, Rk3 (G-Rk3) from Panax ginseng needs to be further explored in order to reveal the mechanisms of action during inhibition. Methodology: Our study focused to investigate the action of G-Rk3 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin aIIbb3 using flow cytometry, intracellular calcium mobilization, dense granule secretion, and thromboxane B2 secretion. In addition, we checked the regulation of phosphorylation on PI3K/MAPK pathway, and thrombin-induced clot retraction was also observed in platelets rich plasma. Key Results: G-Rk3 significantly increased amounts of cyclic adenosine monophosphate (cAMP) and led to significant phosphorylation of cAMP-dependent kinase substrates vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP3R). In the presence of G-Rk3, dense tubular system Ca2 thorn was inhibited, and platelet activity was lowered by inactivating the integrin aIIb/b3 and reducing the binding of fibrinogen. Furthermore, the effect of G-Rk3 extended to the inhibition of MAPK and PI3K/Akt phosphorylation resulting in the reduced secretion of intracellular granules and reduced production of TXA2. Lastly, G-Rk3 inhibited platelet aggregation and thrombus formation via fibrin clot. Conclusions and implications: These results suggest that when dealing with cardiovascular diseases brought upon by faulty aggregation among platelets or through the formation of a thrombus, the G-Rk3 compound can play a role as an effective prophylactic or therapeutic agent. (c) 2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Kwon, Hyuk-Woo; Shin, Jung-Hae; Rhee, Man Hee; Park, Chang-Eun; Lee, Dong-Ha | Far East Univ, Dept Biomed Lab Sci, Eumseong, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu, South Korea; Namseoul Univ, Dept Biomed Lab Sci, Cheonan, South Korea; Namseoul Univ, Mol Diagnost Res Inst, Cheonan, South Korea; Namseoul Univ, Dept Biomed Lab Sci, Cheonan 31020, South Korea | ; Park, Chang-Eun/AEW-4266-2022; Rhee, Man/O-5705-2016 | 55200547400; 56244056800; 57211035357; 57190954987; 57208891222 | dhlee@nsu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 47 | 6 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2023 | 6.8 | 1.2 | 2.37 | 2025-06-25 | 11 | 12 | platelet aggregation; cyclic nucleotide; intracellular Ca 2 thorn; granule secretion | STIMULATED PHOSPHOPROTEIN VASP; CYTOSOLIC PHOSPHOLIPASE A(2); ACTIVATED PROTEIN-KINASES; THROMBUS FORMATION; IN-VITRO; PHOSPHORYLATION; RECEPTOR; PHOSPHODIESTERASES; AGGREGATION; RELEASE | cyclic nucleotide; G-Rk3; granule secretion; intracellular Ca<sup>2+</sup>; platelet aggregation; ` | adenosine triphosphate; anticoagulant agent; calcium; cyclic AMP; cyclic GMP; fibrinogen; ginsenoside; ginsenoside Rk3; inositol 1,4,5 trisphosphate receptor; integrin; integrin alpha2bbeta3; Janus kinase; mitogen activated protein kinase; mitogen activated protein kinase 14; phosphatidylinositol 3 kinase; protein kinase B; serotonin; thrombin; thromboxane B2; unclassified drug; vasodilator stimulated phosphoprotein; antithrombotic activity; Article; blood clotting; calcium cell level; calcium mobilization; controlled study; drug cytotoxicity; enzyme phosphorylation; flow cytometry; human; human cell; MAPK signaling; Pi3K/Akt signaling; serotonin release; thrombocyte; thrombocyte activation; thrombocyte aggregation; Western blotting | English | 2023 | 2023-11 | 10.1016/j.jgr.2023.04.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium | Background: The incidence and clinical importance of nonalcoholic fatty liver disease (NAFLD) has emerged. However, effective therapeutic strategies for NAFLD have yet to be found. Panax ginseng (P. ginseng) is a traditional herb in Eastern Asia with therapeutic effects in many chronic disorders. However, the precise effects of ginseng extract on NAFLD are currently unknown. In present study, the therapeutic effects of Rg3-enriched red ginseng extract (Rg3-RGE) on the progression of NAFLD were explored. Methods: Twelve-week-old C57BL/6 male mice were fed a chow or western diet supplemented with high sugar water solution with or without Rg3-RGE. Histopathology, immunohistochemistry, immunofluorescence, serum biochemistry, western blot analysis, and quantitative RT-PCR were used for in vivo experiment. Conditionally immortalized human glomerular endothelial cell (CiGEnC) and primary liver sinusoidal endothelial cells (LSECs) were used for in vitro experiments.Results: Eight weeks of Rg3-RGE treatment significantly attenuated the inflammatory lesions of NAFLD. Furthermore, Rg3-RGE inhibited the inflammatory infiltrate in liver parenchyma and the expression of adhesive molecules to LSECs. Moreover, the Rg3-RGE exhibited similar patterns on the in vitro assays.Conclusion: The results demonstrate that Rg3-RGE treatment ameliorates NAFLD progression by inhibiting chemotaxis activities in LSECs.(c) 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lee, Seoung-Woo; Baek, Su-Min; Lee, Young-Jin; Kim, Tae-Un; Yim, Jae-Hyuk; Son, Jun-Hyeok; Kim, Hee-Yeon; Kang, Kyung-Ku; Kim, Jong Hun; Rhee, Man Hee; Park, Sang-Joon; Choi, Seong-Kyoon; Park, Jin-Kyu | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Core Prot Resources Ctr, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu, South Korea; Sungshin Womens Univ, Dept Food Sci & Biotechnol, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Histol, Daegu, South Korea; Daegu Gyeongbuk Sci & Technol DGIST, Core Prot Resources Ctr, Daegu 42988, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea | ; Rhee, Man/O-5705-2016 | 57218827581; 57207938426; 57491815500; 57214091908; 57221330255; 57490826800; 58368914700; 57215079376; 57196169639; 57211035357; 7501825941; 55505432500; 35213723500 | cskbest@dgist.ac.kr;jinkyu820@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 47 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2023 | 6.8 | 1.2 | 1.19 | 2025-06-25 | 6 | 6 | chemotaxis; ginsenoside; liver sinusoidal endothelium; NAFLD; VCAM-1 | CELLS; INJURY; PATHOGENESIS; ROLES; MODEL | chemotaxis; ginsenoside; liver sinusoidal endothelium; NAFLD; VCAM-1 | CD68 antigen; ginseng extract; ginsenoside Rg 3; intercellular adhesion molecule 1; vascular cell adhesion molecule 1; animal experiment; animal model; animal tissue; Article; body weight gain; cell adhesion; chow diet; comparative study; controlled study; endothelium cell; fatty liver; fluorescence activated cell sorting; ginseng; histopathology; human; human cell; immunoblotting; immunofluorescence assay; immunohistochemistry; in vitro study; in vivo study; inflammatory cell; Kupffer cell; liver parenchyma; liver sinusoidal endothelial cell; liver sinusoidal endothelium; liver weight; M1 macrophage; M2 macrophage; male; mouse; nonalcoholic fatty liver; nonhuman; protein expression; real time polymerase chain reaction; upregulation; vascular endothelium; Western blotting; Western diet | English | 2023 | 2023-05 | 10.1016/j.jgr.2022.10.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | In silico investigation of Panax ginseng lead compounds against COVID-19 associated platelet activation and thromboembolism | Hypercoagulability is frequently observed in patients with severe coronavirus disease-2019 (COVID-19). Platelets are a favorable target for effectively treating hypercoagulability in COVID-19 patients as platelet hyperactivity has also been observed. It is difficult to develop a treatment for COVID-19 that will be effective against all variants and the use of antivirals may not be fully effective against COVID-19 as activated platelets have been detected in patients with COVID-19. Therefore, patients with less severe side effects often turn toward natural remedies. Numerous phytochemicals are being investigated for their potential to treat a variety of illnesses, including cancer and bacterial and viral infections. Natural products have been used to alleviate COVID-19 symptoms. Panax ginseng has potential for managing cardiovascular diseases and could be a treatment for COVID-19 by targeting the coagulation cascade and platelet activation. Using molecular docking, we analyzed the interactions of bioactive chemicals in P. ginseng with important proteins and receptors involved in platelet activation. Furthermore, the SwissADME online tool was used to calculate the pharmacokinetics and drug-likeness properties of the lead compounds of P. ginseng. Dianthramine, deoxyharrtingtonine, and suchilactone were determined to have favorable pharmacokinetic profiles. (c) 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Quah, Yixian; Lee, Yuan Yee; Lee, Seung-Jin; Kim, Sung Dae; Rhee, Man Hee; Park, Seung-Chun | Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea | ; Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016; Lee, Jun Young/CAI-2335-2022; Yixian, Quah/ABE-7629-2021; Park, Seung-Chun/AAV-3388-2021 | 55886933200; 57203798815; 58689440900; 55156746000; 57211035357; 7501832396 | rheemh@knu.ac.kr;parksch@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 47 | 2 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2023 | 6.8 | 1.2 | 0.79 | 2025-06-25 | 6 | 4 | Panax ginseng; hypercoagulability; platelet aggregation; COVID-19; molecular docking | CD40 LIGAND; BIOAVAILABILITY; SELECTIN; INSIGHTS | COVID-19; hypercoagulability; molecular docking; Panax ginseng; platelet aggregation | alexandrin; amino acid; aposiopolamine; arachidonic acid; CD40 antigen; CD40 ligand; celabenzine; chrysanthemaxanthin; deoxyharringtonine; deoxyharrtingtonine; dianthramine; diop; frutinone a; ginseng extract; ginsenoside Rg 1; ginsenoside rg5; ginsenoside Rh 2; ginsenoside rh4; girinimbin; gomisin; inermin; kaempferol; malkangunin; natural product; P selectin glycoprotein ligand 1; PADGEM protein; panaxadiol; protopine; sitosterol; stigmasterol; suchilactone; thrombin receptor; thrombocyte receptor; unclassified drug; von Willebrand factor; Article; blood brain barrier; cardiovascular disease; chemical analysis; chemical reaction; computer model; coronavirus disease 2019; drug absorption; drug distribution; drug elimination; drug metabolism; ginseng; human; hypercoagulability; intestine absorption; molecular docking; pharmacokinetic parameters; thrombocyte activation; thrombocyte aggregation; thromboembolism; treatment indication | English | 2023 | 2023-03 | 10.1016/j.jgr.2022.09.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | MOF-derived C, N-In2O3 with GdFeO3 Z-scheme heterostructure for the photocatalytic removal of tetracycline | Metal oxides derived from metal-organic frameworks have received considerable attention for water treatment. Herein, MIL-68 (In)-derived rod-like carbon (C) and nitrogen (N) codoped In2O3-modified GdFeO3 (CN-InO/GdF) Z-scheme heterostructures were rationally constructed through simple pyrolysis and a wet-chemical route. The synthesized CN-InO/GdF catalysts were characterized using several physicochemical techniques. Moreover, the obtained CN-InO/GdF exhibited excellent photocatalytic performance toward tetracycline (TC) degradation. Impressively, the optimized CN-InO/GdF-3 heterostructure catalyst displayed a boosted TC removal efficiency of 99.06% within 60 min of irradiation, which was 7.1 and 9.7 times higher than those of bare CN-InO and GdFeO3, respectively. The remarkably enhanced photoactivity of CN-InO/GdF was principally attributed to the synergistically combined interfaces hindering the recombination of photoinduced carriers, and the maintained redox capacity via Z-scheme spatial charge transfer. Finally, the tentative degradation mechanism was determined on the basis of density functional theory calculations and intermediates analysis. This work elucidated the design of highly efficient catalysts for various applications. | Saravanakumar, Karunamoorthy; Jagan, Govindan; Lee, Jongho; Park, Chang Min | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ British Columbia, Dept Civil Engn, Vancouver, BC V6T 1Z4, Canada | Park, Chang Min/CAA-8506-2022; Karunamoorthy, Saravanakumar/Q-2005-2016 | 57223020778; 57885044400; 56741009200; 57209588953 | cmpark@knu.ac.kr; | NPJ CLEAN WATER | NPJ CLEAN WATER | 2059-7037 | 6 | 1 | SCIE | ENGINEERING, CHEMICAL;ENVIRONMENTAL SCIENCES;WATER RESOURCES | 2023 | 10.5 | 1.2 | 2.78 | 2025-06-25 | 23 | 24 | DEGRADATION; OXIDATION | Catalysts; Charge transfer; Degradation; Density functional theory; Gadolinium compounds; Iron compounds; Water treatment; Co-doped; Metal-oxide; Metalorganic frameworks (MOFs); Photo-catalytic removal; Photocatalytic performance; Physicochemical techniques; Simple++; Synthesised; Wet chemical route; ]+ catalyst; irradiation; metal; oxide; performance assessment; photodegradation; pollutant removal; water treatment; Indium compounds | English | 2023 | 2023-11-01 | 10.1038/s41545-023-00288-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Optimal allyl isothiocyanate concentration on Botrytis cinerea during the postharvest storage of blackberries and mechanism of blackberry color changes at high concentration of allyl isothiocyanate | Botrytis cinerea is one of the most important postharvest pathogens causing economical loss in blackberry. To control B. cinerea effectively with safe agent, optimal allyl isothiocyanate (AITC) concentration was determined. Freshly harvested blackberries were placed in a plastic container and treated with AITC at 0, 0.5, 1, 2, 5, and 10 mu L L-1 for 12 h at 4 degrees C, and then stored for 14 d at 4 degrees C and 80 % relative humidity. The B. cinerea incidence of AITC-treated blackberry samples after storage was lower than that of the control. Treatment with AITC at concentrations >= 5 mu L L-1 resulted in a decrease in the total anthocyanin and phenolic contents, antioxidant activity, and surface color. The sucrose, glucose, and fructose levels decreased after treatment with 10 mu L L-1 AITC, suggesting changed energy metabolism. Higher AITC concentrations (5 and 10 mu L L-1) resulted in decreased levels of monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol. By contrast, lysophosphatidylethanolamine (LPE) and lysophosphatidylcholine (LPC) increased in the fruit treated with 5 and 10 mu L L-1 AITC, indicating cell membranes damage related phospolipids. In summary, 2 mu L L-1 AITC was the optimal concentration for blackberry treatment to reduce B. cinerea contamination and extend the fruit shelf-life. In addition, red color of blackberry correlated with LPC and phatidylcholine, which can serve good indicator of reduced cell membrane integrity. This is the first report of metabolomics-based study on controlling B. cinerea during blackberry postharvest storage using AITC. | Park, DoSu; Park, So-Young; Liu, Kwang-Hyeon; Ku, Kang-Mo | Washington State Univ, Tree Fruit Res & Extens Ctr, Dept Hort, Wenatchee, WA 98801 USA; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Korea Univ, Dept Plant Biotechnol, Seoul 02841, South Korea; Kyungpook Natl Univ, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea; Coll Life Sci & Biotechnol, Dept Plant Biotechnol, 145 Anam Ro, Seoul 02841, South Korea | Ku, Kang-Mo/JPL-8941-2023 | 59627743200; 57211630074; 55768214700; 58729600300 | dstlkh@knu.ac.kr;ku_km@korea.ac.kr; | POSTHARVEST BIOLOGY AND TECHNOLOGY | POSTHARVEST BIOL TEC | 0925-5214 | 1873-2356 | 199 | SCIE | AGRONOMY;FOOD SCIENCE & TECHNOLOGY;HORTICULTURE | 2023 | 6.4 | 1.2 | 1.56 | 2025-06-25 | 9 | 9 | Anthocyanin; Allyl isothiocyanate; Mold; Membrane; Postharvest | ANTIOXIDANT ENZYMES; FOOD COLORANTS; ANTHOCYANINS; DEGRADATION; STRAWBERRIES; CAPACITY; ETHYLENE; PATHWAY; FRUIT | Allyl isothiocyanate; Anthocyanin; Membrane; Mold; Postharvest | English | 2023 | 2023-05 | 10.1016/j.postharvbio.2023.112292 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | PAIP 2020: Microsatellite instability prediction in colorectal cancer | Microsatellite instability (MSI) refers to alterations in the length of simple repetitive genomic sequences. MSI status serves as a prognostic and predictive factor in colorectal cancer. The MSI-high status is a good prognostic factor in stage II/III cancer, and predicts a lack of benefit to adjuvant fluorouracil chemotherapy in stage II cancer but a good response to immunotherapy in stage IV cancer. Therefore, determining MSI status in patients with colorectal cancer is important for identifying the appropriate treatment protocol. In the Pathology Artificial Intelligence Platform (PAIP) 2020 challenge, artificial intelligence researchers were invited to predict MSI status based on colorectal cancer slide images. Participants were required to perform two tasks. The primary task was to classify a given slide image as belonging to either the MSI-high or the microsatellite-stable group. The second task was tumor area segmentation to avoid ties with the main task. A total of 210 of the 495 participants enrolled in the challenge downloaded the images, and 23 teams submitted their final results. Seven teams from the top 10 participants agreed to disclose their algorithms, most of which were convolutional neural network-based deep learning models, such as EfficientNet and UNet. The top-ranked system achieved the highest F1 score (0.9231). This paper summarizes the various methods used in the PAIP 2020 challenge. This paper supports the effectiveness of digital pathology for identifying the relationship between colorectal cancer and the MSI characteristics. | Kim, Kyungmo; Lee, Kyoungbun; Cho, Sungduk; Kang, Dong Un; Park, Seongkeun; Kang, Yunsook; Kim, Hyunjeong; Choe, Gheeyoung; Moon, Kyung Chul; Lee, Kyu Sang; Park, Jeong Hwan; Hong, Choyeon; Nateghi, Ramin; Pourakpour, Fattaneh; Wang, Xiyue; Yang, Sen; Jahromi, Seyed Alireza Fatemi; Khani, Aliasghar; Kim, Hwa-Rang; Choi, Doo-Hyun; Han, Chang Hee; Kwak, Jin Tae; Zhang, Fan; Han, Bing; Ho, David Joon; Kang, Gyeong Hoon; Chun, Se Young; Jeong, Won-Ki; Park, Peom; Choi, Jinwook | Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 110799, South Korea; Seoul Natl Univ Hosp, Dept Pathol, Seoul, South Korea; Korea Univ, Coll Informat, Dept Comp Sci & Engn, Seoul, South Korea; Seoul Natl Univ, Dept Elect & Comp Engn, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Biomed Engn, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Pathol, Seoul, South Korea; Seoul Natl Univ, SMG SNU Boramae Med Ctr, Coll Med, Dept Pathol, Seoul, South Korea; Shiraz Univ Technol, Elect & Elect Engn Dept, Shiraz, Iran; Natl Brain Mapping Lab, Iranian Brain Mapping Biobank, Tehran, Iran; Sichuan Univ, Coll Comp Sci, Chengdu, Peoples R China; Sichuan Univ, Coll Biomed Engn, Chengdu, Peoples R China; Tencent AI Lab, Shenzhen, Peoples R China; Sharif Univ Technol, Dept Comp Engn, Tehran, Iran; Kyungpook Natl Univ, Grad Sch Elect & Elect Engn, Daegu, South Korea; Sejong Univ, Dept Comp Sci & Engn, Seoul, South Korea; Korea Univ, Sch Elect Engn, Seoul, South Korea; Canon Med Syst China Co Ltd, Res & Dev Ctr, Beijing, Peoples R China; Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY USA; Seoul Natl Univ, Coll Med, Canc Res Inst, Lab Epigenet, Seoul, South Korea; Seoul Natl Univ, INMC, Dept Elect & Comp Engn, Seoul, South Korea; HuminTec, Suwon, South Korea; Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul, South Korea; 103 Daehak Ro, Seoul 03080, South Korea | ; Chun, Young/B-6653-2013; Kim, Soo-Hyun/D-1577-2019; Jeong, Won-Ki/F-8171-2011; Han, Xiao/GQZ-6090-2022; Kang, DongUn/LFU-8722-2024; Park, Hee-Kyung/IQU-9118-2023; Kim, Hyeong-U/AAV-2668-2021 | 57200261167; 50461719000; 57222723326; 57216372553; 8987790500; 57222726444; 57191719203; 7006443829; 16025039700; 57189704116; 55025989300; 57219472918; 56568166300; 57188869153; 57192120072; 57208099556; 57222162976; 59576456900; 57221832146; 7401642881; 57219469748; 58324535700; 58603726500; 58595350200; 57194464530; 57049735100; 55419135100; 8268624200; 16234086200; 56582817600 | jinchoi@snu.ac.kr;ghkang@snu.ac.kr;ppark@ajou.ac.kr;sychun@snu.ac.kr;wkjeong@korea.ac.kr; | MEDICAL IMAGE ANALYSIS | MED IMAGE ANAL | 1361-8415 | 1361-8423 | 89 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 10.7 | 1.2 | 0.82 | 2025-06-25 | 11 | 11 | Colon cancer; MSI; Digital pathology; Segmentation | MISMATCH REPAIR DEFICIENCY; BRAF MUTATION; MEDICINE; TUMORS | Colon cancer; Digital pathology; MSI; Segmentation | Artificial Intelligence; Colorectal Neoplasms; Fluorouracil; Humans; Microsatellite Instability; Prognosis; Chemotherapy; Classification (of information); Deep learning; Diseases; DNA sequences; Neural networks; fluorouracil; Colon cancer; Digital pathologies; Fluorouracil; Genomic sequence; Microsatellite instability; Predictive factors; Primary task; Prognostic factors; Segmentation; Simple++; algorithm; artificial intelligence; cancer diagnosis; cancer patient; clinical protocol; colorectal cancer; convolutional neural network; data accuracy; deep learning; human; image analysis; image segmentation; microsatellite instability; prediction; Short Survey; treatment outcome; tumor classification; tumor localization; colorectal tumor; genetics; pathology; prognosis; Pathology | English | 2023 | 2023-10 | 10.1016/j.media.2023.102886 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Performance Assessment of Four Grid-Connected Solar Photovoltaic Technologies under Similar Environmental Conditions in Nigeria | This research presents the performance of four grid-connected solar photovoltaic (PV) systems installed at the Adamawa State College of Health Technology, Mubi, Adamawa, Nigeria. The system consists of 3.5 kWp each of four different PV technologies. The mis and psi cells manufactured by China Sunergy and Conergy comprised 14 modules with a power capacity of 250 watts. The asi produced by Moser Baer consists of 10 modules, each having 350 watts, and the CIS manufactured by Solar Frontier has 20 modules, each having 175 watts. The PV was observed and recorded data from January 2022 to December 2022. The system performance was analyzed using eleven evaluation criteria. Based on the technical assessment of the systems for this location, the asi solar PV has the best annual performance. It demonstrated the most favorable performance ratio (PR) and capacity factor (CF) of 90.7% and 27.6%, respectively, when considering energy output, system yields, performance ratio, and capacity ratio. On the other hand, the msi system, manufactured by China Sunergy, exhibited significant efficiencies at both the panel and system levels, with values of 14.3% and 13.7%, respectively. This system stood out for its minimal overall losses, recorded at 7.78 hours, demonstrating superior efficiency and lower overall losses than the other systems under study. This study is critical because the result will provide valuable information to researchers in identifying the appropriate PV systems suitable for Nigeria. In addition, it will assist PV installers and manufacturers with updated information on the PV system with the best performance. | Owolabi, Abdulhameed Babatunde; Yakub, Abdulfatai Olatunji; Luqman, Raji; Same, Noel Ngando; Suh, Dongjun | Kyungpook Natl Univ, Reg Leading Res Ctr Smart Energy Syst, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Sangju 37224, South Korea; Fed Polytech Mubi, Sch Engn, Dept Mech Engn, Mubi, Adamawa State, Nigeria; Fed Polytech Mubi, Ctr Entrepreneurship Dev, Mubi, Adamawa State, Nigeria | 57192210107; 57894905100; 58479611100; 57895613600; 36613529600 | owolabiabdulhameed@gmail.com;yakubabdulfatai1@gmail.com;rajiluqman2020@gmail.com;samenoel1@gmail.com;dongjunsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENERGY RESEARCH | INT J ENERG RES | 0363-907X | 1099-114X | 2023 | SCIE | ENERGY & FUELS;NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 4.3 | 1.2 | 0.23 | 2025-06-25 | 3 | 3 | PV SYSTEM; INTERNATIONAL AIRPORT; MODULE TECHNOLOGIES; CLIMATIC CONDITIONS; POWER-PLANT; REGION; OPTIMIZATION; EFFICIENCY; VIABILITY; DRY | Environmental technology; Solar panels; Solar power generation; Environmental conditions; Grid-connected; Nigeria; Performance; Performance assessment; Performance ratio; Photovoltaic systems; Photovoltaics; Solar photovoltaic system; Solar photovoltaic technology; Solar concentrators | English | 2023 | 2023-09-30 | 10.1155/2023/9458440 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Meeting Abstract | Predictive model for one-session success rate of shock wave lithotripsy using linear calculus density | Kim, G. K.; Bang, S.; Kim, D.; Jun, D. Y.; Jeong, J. Y.; Moon, Y. J.; Kang, D. H.; Jeong, W. S.; Jung, H. D.; Cho, K. S.; Choi, Y. D.; Lee, J. Y. | Yonsei Univ, Dept Urol Urol Sci Inst, Severance Hosp, Coll Med, Seoul, South Korea; Yonsei Univ, Urol Sci Inst, Gangnam Severance Hosp, Dept Urol,Coll Med, Seoul, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Urol, Goyang, South Korea; Kyungpook Natl Univ Hosp, Dept Urol, Daegu, South Korea; Inha Univ, Dept Urol, Coll Med, Incheon, South Korea; Chosun Univ, Dept Urol, Coll Med, Gwangju, South Korea; Inje Univ Ilsan Paik Hosp, Inje Univ Coll Med, Dept Urol, Goyang, South Korea | Kim, Young-Il/ISS-7678-2023; Kim, Kyu/AAJ-7213-2020 | EUROPEAN UROLOGY | EUR UROL | 0302-2838 | 1873-7560 | 83 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 25.3 | 1.2 | 0 | English | 2023 | 2023-02 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Review | Recent Progress of Potassium Metal Anodes: How to Regulate the Growth of Dendrite | Potassium- (K-) based batteries with K metal anodes have been regarded as a substitute for lithium- (Li-) and sodium- (Na-) based batteries. In this review, motivations for K metal anodes with various advantages over Li and Na metals are presented at the beginning. Nevertheless, the practical applications of K metal anodes are still impeded by various challenges originating from their highly reactive nature. Then, major challenges of K metal are introduced in comparison with those of Li and Na metals, including unstable SEI, dendrite growth, low melting point, and gas generation. These issues become more severe in K metal due to its different physical and chemical properties compared with Li and Na metals. Consequently, this leads to varying electrochemical behaviors. In particular, the mechanism of K dendrite growths is different from that of Li and Na. Subsequently, approaches with an emphasis on the suppression of dendrites are described, falling into two categories: direct and indirect engineering on electrodes. Direct engineering is K metallic electrode designs by utilizing a host framework, alloy electrode, and interface modification. Notably, the most crucial aspect considered in direct engineering is the potassiophilicity of the host and interface, which contributes to the uniform deposition of K. The section on indirect engineering addresses the suppression of dendrite growth through separators and liquid/solid electrolytes. Finally, future perspectives and research directions toward the suppression of K dendrites are provided. | Baek, Seunghwi; Jung, Taeksoo; Jie, Sunghyun; Kim, Myeongjin; Lee, Byeongyong | Pusan Natl Univ, Sch Mech Engn, Busan, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu, South Korea | 58452165900; 58024828300; 58024039400; 55541419000; 57189871331 | sunghwi97@pusan.ac.kr;jts5333@pusan.ac.kr;jsh981021@pusan.ac.kr;myeongjinkim@knu.ac.kr;blee1015@pusan.ac.kr; | INTERNATIONAL JOURNAL OF ENERGY RESEARCH | INT J ENERG RES | 0363-907X | 1099-114X | 2023 | SCIE | ENERGY & FUELS;NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 4.3 | 1.2 | 0.23 | 2025-06-25 | 9 | 6 | ELECTROLYTE INTERPHASE SEI; LITHIUM-ION BATTERIES; HIGH-ENERGY-DENSITY; LONG CYCLE LIFE; ROOM-TEMPERATURE; K-ION; INTERCALATION COMPOUND; HIGH-VOLTAGE; LOW-COST; NA-K | Anodes; Lithium; Lithium batteries; Phase interfaces; Alloy electrodes; Dendrite growth; Electrochemical behaviors; Electrode design; Gas generation; Low melting point; Metal anodes; Metallic electrodes; Physical and chemical properties; Recent progress; Potassium | English | 2023 | 2023-12-14 | 10.1155/2023/6680001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Sorption Behavior of Radionuclides on Engineered and Natural Barriers and Prediction of Sorption Distribution Coefficients Using Support Vector Regression | A low- and intermediate-level radioactive waste repository contains various types of radionuclides and organic complexing agents. Their chemical interaction within the repository can lead to the formation of radionuclide-ligand complexes, influencing the limited retention behaviors of radionuclides. This study focuses on the sorption behavior of radionuclides on both engineered (concrete) and natural barriers (sedimentary rock and granite), as well as the prediction of sorption distribution coefficients (Kd) using support vector regression. Batch studies were conducted to determine the Kd values for three radionuclides (99Tc, 137Cs, and 238U) under different conditions, including pH, temperature, and the presence of organic ligands (such as ethylenediaminetetraacetic acid, nitrilotriacetic acid, and isosaccharinic acid). The Kd values for 238U exhibited a sharp decrease with increasing concentrations of organic ligands. In contrast, the Kd values for 99Tc showed only a slight reduction at higher organic ligand concentrations. Meanwhile, the Kd values for 137Cs remained relatively unchanged, regardless of the type and initial concentration of organic ligands. This suggests a high level of retention for 137Cs in the rock samples. The support vector regression model with a radial basis kernel function proved effective in predicting the Kd values under different experimental conditions. This enhancement in predicting accuracy contributes valuable insights into understanding the sorption processes involved in radionuclide behavior. Overall, this study advances our knowledge of radionuclide behavior on both engineered and natural barriers while providing a reliable prediction tool for estimating sorption distribution coefficients. | Lim, Youngsu; Oh, Gi-Taek; Kim, Bolam; Kim, Jinseob; Park, Juhui; Lee, Seongju; Choi, Seho; Jang, Jiseon; Kang, Myunggoo; Ha, Jaechul; Cho, Chun-Hyung; Lee, Min-Woo; Lee, Dae Sung | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Keimyung Univ, Dept Chem Engn, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Korea Radioact Waste Agcy, LILW Technol Team, 19 Chunghyochun Gil, Gyeongju Si 38062, Gyeongsangbug D, South Korea; Korea Radioact Waste Agcy, HLW Technol Dev Inst, 174 Gajeong Ro, Daejeon 34129, South Korea | 57207112603; 57641036600; 57208922438; 58168881100; 58170152500; 58169251700; 59863081100; 56611137400; 57254598100; 57221775357; 57220796131; 58770990800; 55568524907 | rnrn224@knu.ac.kr;dhrlxor5904@naver.com;bolam4783@knu.ac.kr;wlstjq0810@knu.ac.kr;wngml988@knu.ac.kr;cne1171@knu.ac.kr;seho0405@korad.or.kr;jsjang@korad.or.kr;kkang09@korad.or.kr;jcha@korad.or.kr;skycho@korad.or.kr;mwlee@kmu.ac.kr;daesung@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENERGY RESEARCH | INT J ENERG RES | 0363-907X | 1099-114X | 2023 | SCIE | ENERGY & FUELS;NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 4.3 | 1.2 | 0.45 | 2025-06-25 | 3 | 4 | ISOSACCHARINIC ACID; ADSORPTION; SVR; DEGRADATION; REPOSITORY; MIGRATION; DISPOSAL; CONCRETE; GRANITE; IODIDE | Complexation; Ethylenediaminetetraacetic acid; Forecasting; Ligands; Regression analysis; Sedimentary rocks; Sorption; 137Cs; Chemical interactions; Complexing agents; Distribution coefficient; Ligand complexes; Organic ligands; Organics; Radioactive waste repository; Sorption behaviors; Support vector regressions; Radioisotopes | English | 2023 | 2023-12-06 | 10.1155/2023/4760998 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Spent Tea Leaves and Coffee Grounds as Potential Biocathode for Improved Microbial Electrosynthesis Performance | Microbial electrosynthesis (MES) has emerged as a sustainable energy platform capable of simultaneous wastewater treatment and valuable chemical production. The performance of MES, like other bioelectrochemical systems, largely depends on its electrode (cathode), providing the platform for microbial growth as well as electron transfer. However, most of the electrodes are expensive, and their nonrenewable characteristics, cost, and poisoning nature are major bottlenecks in MES commercialization. Thus, several efforts have been made to explore the potential of waste carbon-based electrodes to reduce carbon footprints as well as electrode manufacturing costs. In this study, the feasibility of using spent tea leaves (STL) and spent coffee grounds (SCG) as MES biocathode was tested. Different bioelectrochemical tests suggested improved MES performance with STL and SCG biocathode along with reduced electrode resistance and improved current density. A 1.5- and 2.0-fold increase in cyclic voltammetry (CV) current output was observed for SCG and STL, respectively, with substantial mediator peaks of high intensity indicating enhanced electrocatalytic activity. Enrichment of some fermentative and exoelectrogenic microbial classes such as Clostridia, Bacteroidia, and Deltaproteobacteria led to a 1.3- and 1.4-fold increase in butyrate production for SCG and STL cathode, respectively. These results demonstrate the potential of STL and SCG as MES cathode for improved energy and chemical production. | Tahir, Khurram; Ali, Abdul Samee; Kim, Bolam; Lim, Youngsu; Lee, Dae Sung | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak ro, Daegu 41566, South Korea | Tahir, Khurram/KFS-5321-2024 | 57207114377; 58073888400; 57208922438; 57207112603; 55568524907 | khurram_tahir@knu.ac.kr;abdulsami7358@gmail.com;bolam4783@knu.ac.kr;rnrn224@knu.ac.kr;daesung@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENERGY RESEARCH | INT J ENERG RES | 0363-907X | 1099-114X | 2023 | SCIE | ENERGY & FUELS;NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 4.3 | 1.2 | 0.34 | 2025-06-25 | 1 | 3 | ANODE MATERIAL; ELECTRODE | Carbon footprint; Costs; Cyclic voltammetry; Gene expression; Organic carbon; Wastewater treatment; Bio-electrochemical; Biocathodes; Chemical production; Coffee grounds; Microbial growth; Performance; Spent coffee grounds; Spent tea leaves; Sustainable energy; Valuable chemicals; Cathodes | English | 2023 | 2023-02-24 | 10.1155/2023/1318365 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Systemic and molecular analysis dissect the red ginseng induction of apoptosis and autophagy in HCC as mediated with AMPK | Background: Hepatocellular carcinoma (HCC) has a high incidence and is one of the highest mortality cancers when advanced stage is proceeded. However, Anti-cancer drugs available for treatment are limited and new anti-cancer drugs and new ways to treat them are minimal. We examined that the effects and possibility of Red Ginseng (RG, Panax ginseng Meyer) as new anti-cancer drug on HCC by combining network pharmacology and molecular biology.Materials and Methods: Network pharmacological analysis was employed to investigate the systems -level mechanism of RG focusing on HCC. Cytotoxicity of RG was determined by MTT analysis, which were also stained by annexin V/PI staining for apoptosis and acridine orange for autophagy. For the analyze mechanism of RG, we extracted protein and subjected to immunoblotting for apoptosis or autophagy related proteins.Results: We constructed compound-target network of RG and identified potential pathways related to HCC. RG inhibited growth of HCC through acceleration of cytotoxicity and reduction of wound healing ability of HCC. RG also increased apoptosis and autophagy through AMPK induction. In addition, its ingredients, 20S-PPD (protopanaxadiol) and 20S-PPT (protopanaxatriol), also induced AMPK mediated apoptosis and autophagy.Conclusion: RG effectively inhibited growth of HCC cells inducing apoptosis and autophagy via ATG/ AMPK in HCC cells. Overall, our study suggests possibility as new anti-cancer drug on HCC by proof for the mechanism of the anti-cancer action of RG.(c) 2023 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Kim, Young Woo; Bak, Seon Been; Lee, Won-Yung; Bae, Su Jin; Lee, Eun Hye; Yang, Ju-Hye; Kim, Kwang Youn; Song, Chang Hyun; Kim, Sang Chan; Yun, Un-Jung; Park, Kwang Il | Dongguk Univ, Sch Korean Med, Gyeongju, South Korea; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Korea Inst Oriental Med, Korean Med KM Applicat Ctr, Daegu, South Korea; Daegu Haany Univ, Coll Korean Med, MRC Ctr, Gyongsan, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Physiol, Jinju, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Physiol, Jinju 52828, South Korea; Dongguk Univ, Sch Korean Med, Gyeongju 38066, South Korea; Daegu Haany Univ, Coll Korean Med, MRC Ctr, Gyeonsan 38610, South Korea | Kim, Sang Chan/IUQ-5763-2023; Yang, Ju-Hye/GNH-6607-2022 | 55699527800; 57455566300; 57207303603; 57437662600; 57189661699; 57061012700; 58076309300; 24403187800; 8960688000; 6603356818; 55722171100 | sckim@dhu.ac.kr;yun2546@gmail.com;kipark@gnu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 47 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2023 | 6.8 | 1.2 | 0.59 | 2025-06-25 | 4 | 4 | Red ginseng; Apoptosis; HCC; AMPK; Network pharmacology | EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; CANCER-CELLS; LUNG-CANCER; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY; PANAX-GINSENG; DEATH; LIVER; RG3 | AMPK; Apoptosis; HCC; Network pharmacology; Red ginseng | acridine orange; autophagy related protein; hydroxymethylglutaryl coenzyme A reductase kinase; lipocortin 5; protopanaxadiol; acceleration; AMPK signaling; apoptosis; Article; autophagy (cellular); cancer growth; cell culture; cell survival; cell viability; cell viability assay; controlled study; cytotoxicity; gene set enrichment analysis; ginseng; Huh-7 cell line; human; human cell; immunoblotting; KEGG; liver cell carcinoma; molecular biology; MTT assay; nonhuman; signal transduction; systems pharmacology; Western blotting; wound healing; wound healing assay | English | 2023 | 2023-05 | 10.1016/j.jgr.2023.02.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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