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| ○ | ○ | Article | Combined UV-B and methyl jasmonate treatments enhance postharvest pigmentation of ?Fuji? apples | The red color of postharvest apples is an important quality factor. Mixed colors cause a decrease in consumer purchase, even if other quality factors between apples are similar. The purpose of this study was to determine how well UV-B and surface colorant treatments (MeJA: methyl jasmonate; EP: ethephon) induce color changes in mixed-color apples after harvest. Partially less-pigmented apples were developed by artificial sun-blocking, and they were harvested during the regular harvest period. The harvested apples were irradiated with UV-B with/ without colorants. UV-B irradiation alone or combined with EP increased cyanidin-3-O-galactoside (idaein) content in the less-pigmented skin to 50% of the level found in naturally pigmented skin. On the other hand, irradiation with UV-B and MeJA for 48 h had synergistic effects on idaein accumulation that produced almost 100% of the level found in naturally pigmented skin. Genes of the anthocyanin pathway, such as MdUFGT and MdDFR, were synergistically overexpressed in the treatment group that received UV-B irradiation and MeJA together. MdDFR2 was overexpressed to a level similar to MdDFR1 at 24 h and was higher at 48 h. The expression of other flavonoid biosynthetic genes, MdMYB10, MdCHS, MdCHI, MdF3H, MdFLS, MdLDOX, and MdUFGT, was induced by 24 h of UV-B irradiation, regardless of colorant treatment. The quercetin glycosides, except for quercetin-3-O-rutinoside, increased significantly when UV-B and colorant treatments were applied. These results suggest that short-term combination treatment with UV-B and MeJA is an efficient method for improving postharvest apple coloration. | Ryu, Jung-A; Duan, Shucheng; Gil, Chan Saem; Jeong, Ho Young; Lee, Chanhui; Kang, In-Kyu; Eom, Seok Hyun | Gyeongsangbuk do Agr Res & Extens Serv, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Smart Farm Sci, Yongin 17104, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Plant & Environm New Resources, Yongin 17104, South Korea | 57216744726; 57221500551; 57195527066; 57207963667; 23005580300; 56577308800; 15836623800 | kangik@knu.ac.kr;se43@khu.ac.kr; | POSTHARVEST BIOLOGY AND TECHNOLOGY | POSTHARVEST BIOL TEC | 0925-5214 | 1873-2356 | 190 | SCIE | AGRONOMY;FOOD SCIENCE & TECHNOLOGY;HORTICULTURE | 2022 | 7 | 1.7 | 1.42 | 2025-06-25 | 13 | 14 | Anthocyanin; Fruit color; Pigmentation; Quercetin glycosides; Ultraviolet-B | CHLOROGENIC ACID LEVELS; CRIPPS PINK APPLE; ANTHOCYANIN ACCUMULATION; FRUIT MATURATION; LIGHT; ETHYLENE; GENES; SKIN; RED; EXPRESSION | Anthocyanin; Fruit color; Pigmentation; Quercetin glycosides; Ultraviolet-B | English | 2022 | 2022-08 | 10.1016/j.postharvbio.2022.111938 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Molecularly imprinted polymer-based electrochemical impedimetric sensors on screen-printed carbon electrodes for the detection of trace cytokine IL-1β | In this study, protein-imprinted sensors were electrochemically fabricated on screen-printed carbon electrodes (SPCEs) for the cytokine interleukin-1 beta (IL-1 beta) detection. A double layer comprising poly(o-phenylenediamine) and poly(chromotrope 2R) with a template (i.e., IL-1 beta biomacromolecules) was formed through the cyclic vol-tammetry (CV) technique to modify the molecularly imprinted polymer (MIP) films on the SPCEs. The elec-trochemical sensing properties were investigated via CV and electrochemical impedance spectroscopy to confirm the imprinting effect on the MIP films. The results show that the MIP sensor has a highly sensitive response in the trace IL-1 beta solution (a few pg/mL) with a limit of detection of 0.23 pg/mL and a limit of quantification of 0.78 pg/mL. Furthermore, the MIP sensor showed high selectivity for IL-1 beta adsorption compared to other proteins. In summary, based on binary double layers, the impedance sensing platforms of electropolymerized MIP films show potential application in the practical detection of macromolecular proteins. | Choi, Doo Young; Yang, Jin Chul; Hong, Suck Won; Park, Jinyoung | Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Pusan Natl Univ, Dept Opt & Mechatron Engn, Dept Cogno Mechatron Engn, Coll Nanosci & Nanotechnol, Busan 46241, South Korea | ; PARK, JUN-YOUNG/P-5981-2015 | 57286747400; 56381794400; 57252820400; 57286293400 | jinpark@knu.ac.kr; | BIOSENSORS & BIOELECTRONICS | BIOSENS BIOELECTRON | 0956-5663 | 1873-4235 | 204 | SCIE | BIOPHYSICS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 12.6 | 1.7 | 3.31 | 2025-06-25 | 36 | 38 | Protein imprinting; Interleukin-1 beta; Cytokine; Electropolymerization; Differential pulse voltammetry; Impedimetric analysis | CURRENT STATE; SALIVA; SERUM; INTERLEUKIN-1-BETA; TECHNOLOGY; PLATFORM; ACID | Cytokine; Differential pulse voltammetry; Electropolymerization; Impedimetric analysis; Interleukin-1β; Protein imprinting | Biosensing Techniques; Carbon; Cytokines; Electrochemical Techniques; Electrodes; Interleukin-1beta; Limit of Detection; Molecular Imprinting; Molecularly Imprinted Polymers; Carbon; Cyclic voltammetry; Electrochemical electrodes; Electrochemical impedance spectroscopy; Polymer films; Proteins; interleukin 1beta; molecularly imprinted polymer; phenylenediamine derivative; phosphate buffered saline; poly(2 phenylenediamine); poly(chromotrope 2R); unclassified drug; carbon; cytokine; interleukin 1beta; molecularly imprinted polymer; Cytokines; Differential pulse voltammetry; Double layers; Electropolymerisation; Impedimetric analyse; Interleukin 1β; Molecularly imprinted polymer films; Molecularly imprinted polymer-sensor; Protein imprinting; Screen-printed carbon electrodes; adsorption; Article; controlled study; cyclic voltammetry; differential pulse voltammetry; electrochemical analysis; electrochemistry; electropolymerization; human; impedance spectroscopy; impedimetric analysis; limit of detection; limit of quantitation; macromolecule; male; molecular imprinting; polymerization; protein analysis; serum; chemistry; electrode; genetic procedures; molecular imprinting; procedures; Electropolymerization | English | 2022 | 2022-05-15 | 10.1016/j.bios.2022.114073 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Osteoarthritis year in review 2022: biology | The field of osteoarthritis (OA) biology is rapidly evolving and brilliant progress has been made this year as well. Landmark studies of OA biology published in 2021 and early 2022 were selected through PubMed search by personal opinion. These papers were classified by their molecular mechanisms, and it was largely divided into the intracellular signaling mechanisms and the inter-compartment interaction in chondrocyte homeostasis and OA progression. The intracellular signaling mechanisms involving OA progression included (1) Piezo1/transient receptor potential channels of the vanilloid subtype ( TRPV) 4-mediated calcium signaling, (2) mechanical load-F-box and WD repeat domain containing 7 (FBXW7) in chondrocyte senescence, (3) mechanical loading-primary cilia-hedgehog signaling, (4) low grade inflammation by toll-like receptor (TLR)-CD14-lipopolysaccharide-binding protein (LBP) complex and inhibitor of NF-kB kinase (IKK) beta-nuclear factor kappa B (NF-kappa B) signaling, (5) selenium pathway and reactive oxygen species (ROS) production, (6) G protein-coupled receptor ( GPCR) and cyclic adenosine monophosphate (cAMP) signaling, (7) peroxisome proliferator-activated receptor alpha (PPAR alpha)-acyl-CoA thioesterase 12 (ACOT12)-mediated de novo lipogenesis and (8) hypoxia-disruptor of telomeric silencing 1-like (DOT1L)-H3-lysine 79 (H3K79) methylation pathway. The studies on inter-compartment or intercellular interaction in OA progression included the following subjects; (1) the anabolic role of lubricin, glycoprotein from superficial zone cells, (2) osteoclast-chondrocyte interaction via exosomal miRNA and sphingosine 1-phosphate (S1P), (3) senescent fibroblast-like synoviocyte and chondrocyte interaction, (4) synovial macrophage and chondrocyte interaction through Flightless I, (5) alpha V integrinmediated transforming growth factor beta (TGF beta) activation by mechanical loading, and (6) osteocytic TGFb in subchondral bone thickening. Despite the disastrous Covid-19 pandemic, many outstanding studies have expanded the boundary of OA biology. They provide both critical insight into the pathophysiology as well as clues for the treatment of OA. (c) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. | Han, S. | Kyungpook Natl Univ, Res Inst Aging & Metab, Lab Arthrit & Cartilage Biol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Han, Seungwoo/R-5326-2019 | 55246807000 | kiefedr@knu.ac.kr; | OSTEOARTHRITIS AND CARTILAGE | OSTEOARTHR CARTILAGE | 1063-4584 | 1522-9653 | 30 | 12 | SCIE | ORTHOPEDICS;RHEUMATOLOGY | 2022 | 7 | 1.7 | 3.91 | 2025-06-25 | 63 | 68 | Osteoarthritis; Chondrocytes; Biology; Review | WIDE DNA METHYLATION; LUBRICIN; CILIA | Biology; Chondrocytes; Osteoarthritis; Review | Biology; Chondrocytes; COVID-19; Hedgehog Proteins; Humans; Ion Channels; NF-kappa B; Osteoarthritis; Pandemics; Thiolester Hydrolases; Transforming Growth Factor beta; ADAMTS protein; alpha5 integrin; CD14 antigen; collagenase 3; cyclic AMP; cyclic AMP dependent protein kinase; F box/WD repeat containing protein 7; G protein coupled receptor; glutathione peroxidase 1; glycogen synthase kinase 3beta; hydroxymethylglutaryl coenzyme A reductase kinase; hypoxia inducible factor 1alpha; I kappa B kinase beta; interleukin 1alpha; interleukin 1beta; lipopolysaccharide binding protein; microRNA; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase kinase 7; palmitoyl coenzyme A hydrolase; peroxisome proliferator activated receptor alpha; reactive oxygen metabolite; sclerostin; selenium; Smad2 protein; sphingosine 1 phosphate; stress activated protein kinase; toll like receptor; transcription factor Sox9; transforming growth factor beta; vanilloid receptor 4; zinc transporter 8; ACOT12 protein, human; immunoglobulin enhancer binding protein; ion channel; PIEZO1 protein, human; sonic hedgehog protein; thiol ester hydrolase; transforming growth factor beta; apoptosis; calcium signaling; cAMP signaling; chondrocyte; DNA methylation; endotoxemia; extracellular matrix; fibroblast; hedgehog signaling; homeostasis; human; hypoxia; intracellular signaling; lipogenesis; mechanical stress; medial meniscus; NF kB signaling; osteoarthritis; osteosclerosis; phosphorylation; Review; subchondral bone; synoviocyte; systematic review; TLR signaling; biology; metabolism; pandemic | English | 2022 | 2022-12 | 10.1016/j.joca.2022.09.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Recent advances in urea-formaldehyde resins: converting crystalline thermosetting polymers back to amorphous ones | Since their first synthesis in 1884, thermosetting and amorphous urea-formaldehyde (UF) resins have mainly been used as wood adhesives yet are known to be responsible for the release of formaldehyde, which contaminates indoor air and causes sick building syndrome. An easy and efficient way of reducing formaldehyde emissions is to synthesize UF resins with a low formaldehyde-to-urea (F/U) molar ratio (similar to 1.0). However, low molar ratio UF resins become crystalline polymers, as they form hydrogen bonds between linear molecules in the cured state, which inhibits the formation of a proper cross-linked structure and results in poor adhesion strength. Herein, recent advances in converting crystalline UF resins back to amorphous polymers through the blocking of hydrogen bonds are described, which consequently increases their cohesion, leading to a simultaneous improvement in their adhesion properties and formaldehyde emissions. | Wibowo, Eko Setio; Park, Byung-Dae; Causin, Valerio | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu, South Korea; Univ Padua, Departimento Sci Chim, Padua, Italy | Wibowo, Eko/AAL-5888-2021; Park, Byung-Dae/ABB-1934-2020; Causin, Valerio/ABB-2444-2021 | 57214910272; 7402834820; 6602309019 | byungdae@knu.ac.kr; | POLYMER REVIEWS | POLYM REV | 1558-3724 | 1558-3716 | 62 | 4 | SCIE | POLYMER SCIENCE | 2022 | 13.1 | 1.7 | 1.02 | 2025-06-25 | 32 | 38 | UF resins; formaldehyde emissions; hydrogen bonds; crystalline; amorphous | CHEMICAL-SHIFT; SOLID-STATE; MOLE RATIO; MELAMINE-FORMALDEHYDE; NMR; EMISSION; ADHESIVES; C-13; MECHANISM; ACID | amorphous; crystalline; formaldehyde emissions; hydrogen bonds; UF resins | Adhesives; Formaldehyde; Hydrogen Bonds; Metabolism; Polyureas; Adhesives; Crosslinking; Formaldehyde; Hydrogen bonds; Indoor air pollution; Intelligent buildings; Molar ratio; Resins; Urea; Urea formaldehyde resins; Crosslinked structures; Crystalline polymers; Formaldehyde emission; Indoor air; Linear molecules; Molar ratio; Sick building syndrome; Thermosetting polymers; Urea-formaldehyde resin; Wood adhesives; Metabolism | English | 2022 | 2022-10-02 | 10.1080/15583724.2021.2014520 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficient stacking of glucose/oxygen microfluidic biofuel cells using a single-streamflow | The stacking of microfluidic enzymatic biofuel cells (EBFCs) is a lucrative approach to achieve the targeted power requirements of microelectronic devices. Co-laminar flow based microfluidic EBFCs favour easy and costeffective microfabrication owing to membrane-less architecture. However, stacking of these unit cells in large number is inefficient due to cross-mixing issues, especially in the cells located downstream of the stack. In this article, we present two-dimensional stacking of four single-streamflow-based EBFCs in a cascade-style serpentine-shaped microfluidic channel. A novel attribute of the device is the identical fuel utilisation in all cells due to mixed single electrolyte stream, which results in stable connection efficiencies. In addition, a novel composite material was used as an air-breathing biocathode implementing the cathodic enzyme covalently immobilised onto carboxyl multiwalled carbon nanotubes (MWCNTs). Negatively charged carboxyl MWCNTs were conformally attached to the highly porous structure of Toray carbon paper (TCP) using positively charged polyethyleneimine (PEI) by electrostatic layer-by-layer (LBL) deposition. At the bioanode, the enzyme and mediator were immobilised on the MWCNTs by a cross-linking method. The experimental results showed that enzyme immobilisation increased proportionally with the number of PEI/MWCNTs bilayers on TCP. When the bioelectrode was analysed individually with five layers of MWCNTs via cyclic voltammetry (CV), the catalytic performance was increased by 4.4-fold. Moreover, the unit cells in the microfluidic stacking device were connected in various configurations i.e., all in series, all in parallel, and series/parallel combined configuration. The connection efficiencies obtained for all the configurations were stable, thereby validating the potential of stacking single-stream microfluidic EBFCs in large number to satisfy the power requirements of small-scale electronic devices. | Khan, Haroon; Tanveer, Muhammad; Dang Dinh Nguyen; Ullah, Asad; Shin, Min Chul; Kwak, Moon Kyu; Park, Cheol Woo; Kim, Gyu Man | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Univ Engn & Technol, Dept Mech Engn, Mardan 23200, Khyber Pakhtunk, Pakistan | Shin, Min/AAU-6206-2021; Tanveer, MuhammadShahbaz/LUY-0421-2024; ULLAH, ASAD/HME-1580-2023; Kwak, Moon/AGQ-6058-2022 | 14521310700; 23486949200; 57917198100; 57226132377; 57216174671; 57203947984; 7408416474; 55664733000 | gyuman.kim@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 271 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2022 | 10.4 | 1.8 | 0.74 | 2025-06-25 | 9 | 10 | Microfluidic; Glucose/ Oxygen biofuel cell; Single streamflow; Stacking | IMPROVED FUEL UTILIZATION; PERFORMANCE; DEHYDROGENASE; ELECTRODES; FEATURES; DESIGN | Glucose/ Oxygen biofuel cell; Microfluidic; Single streamflow; Stacking | Biofuels; Cells; Cost effectiveness; Cyclic voltammetry; Cytology; Efficiency; Electrolytes; Enzymatic fuel cells; Enzymes; Fluidic devices; Glucose; Laminar flow; Microelectronics; Multiwalled carbon nanotubes (MWCN); Serpentine; Shear stress; Carbon paper; Carboxyl multi-walled carbon nanotubes; Cell/B.E; Glucose/ oxygen biofuel cell; Multi-walled-carbon-nanotubes; Poly(ethyleneimine); Power requirement; Single streamflow; Stackings; Unit cells; Microfluidics | English | 2022 | 2022-11-01 | 10.1016/j.enconman.2022.116270 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inhibition of factor Xa activity, platelet aggregation, and experimentally induced thrombosis by Sparstolonin B | Background:: Sparstolonin B (SsnB) is an isocumarin compound extracted from medicinal plants such as Spar-ganium stoloniferum and Scirpus yagara with well documented anti-inflammatory activity. Here we examined if SsnB also possesses antithrombotic activity and the underlying mechanisms. Methods:: Anti-thrombotic effects of SsnB were determined by measuring in vitro/ex vivo/in vivo clotting times, platelet aggregation assay, production and activity of factor Xa, nitric oxide, and expressions of relative proteins. Results: : Treatment with SsnB prolonged the clotting time of human platelet-poor serum at concentrations comparable to the clinical anticoagulant rivaroxaban (as a positive control) and inhibited human platelet ag-gregation induced by adenosine diphosphate (ADP) or the thromboxane A2 analog U46619. SsnB also inhibited U46619-induced and ADP-induced phosphorylation of phospholipase C (PLC)gamma 2/protein kinase C (PKC) and intracellular calcium mobilization, both of which are required for platelet aggregation. In addition, SsnB inhibited expression of the cell adhesion factors P-selectin and PAC-1. SsnB increased production of the vaso-dilator nitric oxide and suppressed secretion of the vasoconstrictor endothelin-1 from ADP-or U46619-treated human umbilical vein endothelial cells. Further, SsnB reduced coagulation factor Xa (FXa) catalytic activity and production by endothelial cells as well as FXa-induced platelet aggregation. Conclusion:: Finally, SsnB injection reduced thrombus formation time, number, size, and related mortality in mouse models of thromboembolism. SsnB is a promising antithrombotic agent targeting both FXa and platelet aggregation pathways, which can overcome the side effects of existing antithrombotic agents. | Kim, Nayeon; Jeon, CheLynn; Kim, Chaeyeong; Ryu, Soo Ho; Lee, Wonhwa; Bae, Jong-Sup | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea | Bae, Jong-Sup/AAU-9724-2020; Lee, Wonhwa/GLQ-6506-2022 | 57226179942; 57452007000; 57418696700; 57418127000; 50161632800; 16021543200 | Wonhwalee@skku.edu;baejs@knu.ac.kr; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 99 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2022 | 7.9 | 1.8 | 0.6 | 2025-06-25 | 6 | 6 | Sparstolonin B; FXa; Platelet aggregation; Thrombosis | LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; PROFIBRINOLYTIC ACTIVITIES; NITRIC-OXIDE; IN-VITRO; ANTI-IIA; ANTIPLATELET; RIVAROXABAN; COAGULATION; POTENT; ANTAGONIST | FXa; Platelet aggregation; Sparstolonin B; Thrombosis | adenosine diphosphate; anticoagulant agent; blood clotting factor 10a; blood clotting factor 10a inhibitor; calcium; chromogenic substrate; collagen; coumarin derivative; cyclic GMP; dual specificity phosphatase 2; endothelin 1; epinephrine; nitric oxide; PADGEM protein; phospholipase C gamma2; protein kinase C; rivaroxaban; sparstolonin B; thromboxane A2; unclassified drug; animal experiment; animal model; antithrombotic activity; artery thrombosis; Article; blood clotting time; calcium cell level; catalysis; cell viability assay; controlled study; enzyme activation; enzyme phosphorylation; ex vivo study; fluorescence; health care; human; human cell; human tissue; in vitro study; in vivo study; microvascular thrombosis; mouse; nonhuman; platelet aggregation assay; protein expression; pulmonary thrombosis; thrombocyte; thrombocyte aggregation; thrombocyte poor plasma; thrombocyte rich plasma; thrombosis; umbilical vein endothelial cell; Western blotting | English | 2022 | 2022-05 | 10.1016/j.phymed.2022.153987 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Moringa oleifera mitigates ethanol-induced oxidative stress, fatty degeneration and hepatic steatosis by promoting Nrf2 in mice | Background: Moringa oleifera (M. oleifera) is cultivated throughout the world and it is known by numerous regional names and is consumed as medication for various diseases such as hypertension, diabetes, HIV and is potential source of nutrients and natural antioxidants making it among the most useful trees. Methods: We evaluated the therapeutic potential of M. oleifera on ethanol-induced fatty liver. The mice were treated with 30% ethanol (EtOH) alone or in combination with different concentration of M. oleifera extracts (100, 200 and 400 mg/kg). We performed biochemical estimation for the serum of important liver damage markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglyceride (TG). We performed histopathological analysis from the liver tissues of different mice groups. We also performed ELISA assay, western blotting analysis and SPECT imaging to obtain our results. Results: The results for serum (AST, p < 0.0001), (ALT, p < 0.0006) and triglyceride (TG, p < 0.0003) were found to be significantly reduced in all doses of M. oleifera extract treatment groups in comparison with the ethanol group. H&E staining analysis and scoring revealed a significant reduction in lipid droplet accumulation and a significant reduction of liver steatosis (p < 0.0001), lobular inflammation (p < 0.0013), ballooning (p < 0.0004) and immunohistochemistry for TNF-alpha. M. oleifera also ameliorated ethanol-induced oxidative stress evaluated through MDA (p < 0.0001), H2DCFDA, JC-1 staining and a significant down-regulation of CYP2E1 enzyme (p < 0.0001) in the 200 and 400 mg/kg groups in comparison with EtOH groups. M. oleifera extract also boosted the antioxidant response evaluated through total GSH assay (p < 0.0001) and nuclear translocation of Nrf2. Furthermore, we performed SPECT imaging and evaluated the liver uptake value (LUV) to assess the extent of liver damage. LUV was observed to be lower in the ethanol group, whereas LUV was higher in control and M. olifera treated groups. Conclusion: In summary, from this experiment we conclude that M. oleifera extract has the potential to ameliorate ethanol-induced liver damage. | Kim, Chang Geon; Chang, Sukkum Ngullie; Park, Seon Min; Hwang, Buyng Su; Kang, Sung-A; Kim, Kil Soo; Park, Jae Gyu | Pohang Technopk Fdn, Adv Bio Convergence Ctr ABCC, Pohang 37668, Gyeongbuk, South Korea; Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea; Daegu Univ, Dept Biotechnol, Gyongsan 38453, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Toxicol, Daegu 41566, South Korea; Nakdonggang Natl Inst Biol Resources, Sangju 37242, South Korea | Chang, Sukkum Ngullie/AAD-5352-2022; Hwang, Buyng/AAP-6681-2020; Park, Mi-Kyung/J-9643-2017; Kim, Seung/N-5248-2019; Chang, Sukkum/AAD-5352-2022 | 57222869611; 57190228238; 57221694051; 35484054800; 57553553500; 35272034300; 57190427098 | kskim728mail@knu.ac.kr;jaegpark@gmail.com; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 100 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2022 | 7.9 | 1.8 | 2.9 | 2025-06-25 | 23 | 24 | Moringa oleifera; Ethanol-induced fatty liver; Lipid droplets; SPECT; CT imaging; Technetium-99 m ( 99m Tc) | Lipid droplets, SPECT/CT imaging; Moringa oleifera, Ethanol-induced fatty liver; Technetium-99 m (<sup>99m</sup>Tc) | Animals; Antioxidants; Ethanol; Fatty Liver; GA-Binding Protein Transcription Factor; Liver; Mice; Moringa oleifera; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Triglycerides; alanine aminotransferase; alcohol; aspartate aminotransferase; astragalin; cytochrome P450 2E1; eosin; fat droplet; glutathione; hematoxylin; kaempferol 3 o acetyl glucoside; malonaldehyde; Moringa oleifera extract; multiflorin B; plant medicinal product; quercetin 3 (6'' malonyl) glucoside; quercetin 3 o beta dextro glucoside; transcription factor Nrf2; triacylglycerol; unclassified drug; vitexin; alcohol; antioxidant; GA binding protein; plant extract; transcription factor Nrf2; triacylglycerol; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; bioaccumulation; biochemical analysis; concentration (parameter); controlled study; down regulation; enzyme linked immunosorbent assay; fatty liver; histopathology; immunohistochemistry; liver fatty degeneration; liver tissue; male; Moringa oleifera; mouse; nonhuman; oxidative stress; reduction (chemistry); single photon emission computed tomography; triacylglycerol blood level; Western blotting; animal; liver; metabolism; oxidative stress | English | 2022 | 2022-06 | 10.1016/j.phymed.2022.154037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | No-vacuum Mono-Tube Compound Parabolic Collector Receiver for Linear Fresnel Concentrator: Numerical and Experimental Approach for Dynamic Behavior Assessment | The present paper aims to develop a novel simplified transient model to investigate the dynamic behavior of a no -vacuum mono-tube receiver equipped with a compound parabolic collector. Considering the intermittency of solar radiation, predicting receiver thermal behavior is critical for linear Fresnel concentrator design and operation. From this standpoint, this research focuses on determining whether or not the steady-state assumption influences the receiver's performance. Unlike the current models accounting for all the receiver components, the proposed model considers the absorber tube as the primary node and focuses on the heat transfer fluid temperature distribution. The remaining components form an equivalent thermal resistance through which heat loss occurs. The global heat losses are then characterized using an experimental receiver prototype with tube diameter of 70 mm, an aperture of 500 mm, and a secondary reflector. The overall receiver heat loss coefficient was determined at different absorber temperatures ranging between 60 and around 265 ?. The heat loss coefficients measured varied from 4.7 to 8.5 W/m(2) K. The model computes receiver performance using the measured overall heat loss coefficient based on real solar data. The receiver response at steady and transient states has been conducted and discussed according to several design parameters, including the heat transfer fluid nature and mass flow rate, the receiver length, and the absorber tube thickness. For the same working conditions, synthetic oils fluid allows achieving higher efficiencies whereas molten salts enable reaching higher outlet temperatures. For the metal wall thicknesses ranging between 2 and 3 mm and the fluid outlet temperature varying between 250 and 300 ?, the receiver thermal efficiency during the day remains relatively close to 75 %. The impact of the absorber tube thermal inertia has been investigated by analyzing the dynamic behavior under various close-to-real-world scenarios. Results have shown that the steady-state assumption does not influence if the metal wall tube thickness is lower than 3 mm. | Baba, Yousra Filali; Al Mers, Ahmed; Tauseef-ur-Rehman, Tauseef; Ajdad, Hamid; Bouatem, Abdelfattah; Faik, Abdessamad; Idrissi, Badr Bououlid | Mohammed VI Polytech Univ UM6P, Lot 660,Hay Moulay Rachid, Ben Guerir 43150, Morocco; Abdelmalek Essaadi Univ, Phys Syst Design PSD Lab, FS, Tetouan 93000, Morocco; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Moulay Ismail Univ, Ecole Natl Super Arts & Metiers Meknes, Dept Energy, 3ER Team, BP 15290 El Mansour, Meknes 50500, Morocco | ; Faik, Abdessamad/K-4737-2015; Rehman, Tauseef-ur/AAE-3086-2022 | 57194346885; 14029854300; 57807760800; 56241874100; 55810076500; 19337071200; 56085916700 | yousra.filalibaba@um6p.ma; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 268 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2022 | 10.4 | 1.8 | 0.66 | 2025-06-25 | 8 | 9 | Thermal performances; linear Fresnel concentrator; no -vacuum mono -tube compound parabolic; collector receiver; simplified model; experimental characterization; heat loss; inertia term | HEAT-LOSS; COATINGS | experimental characterization; heat loss; inertia term; linear Fresnel concentrator; no-vacuum mono-tube compound parabolic collector receiver; simplified model; Thermal performances | Collector efficiency; Concentration (process); Heat resistance; Heat transfer; Tubes (components); Absorber tubes; Dynamic behaviors; Experimental characterization; Inertia terms; Linear fresnel; Linear fresnel concentrator; No-vacuum mono-tube compound parabolic collector receiver; Parabolic collector; Simplified model; Thermal Performance; Heat losses | English | 2022 | 2022-09-15 | 10.1016/j.enconman.2022.115986 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Paper-based microfluidic fuel cells and their applications: A prospective review | Since they firstly appeared in 2014, paper-based microfluidic fuel cells (PMFC) have received great attention in the past few years, mainly being used for sensors, wearable devices, point-of-care testing and diagnostics. This fuel cell technology exploits the intrinsic characteristics of paper substrate and microfluidic flows of reactant streams eliminating the need for external pumps and conventional membranes. PMFCs operate in a co-laminar flow configuration, and the absence of convective mixing across the liquid-liquid interface of two streams forms a distinct diffusive mixing region, which acts as a pseudo-membrane. The hydrophilicity and porosity of paper substrate allows reactants to flow by capillarity with the assistance of an absorbent pad. Ions can be transported across the channel through the mixing region to reach the other side of the channel and complete ionic conduction. To date, several fuels have been utilised in PMFCs, such as formate, hydrogen, formic acid, hydrogen peroxide, hydrocarbons, borohydride, hydrazine, and biofuels, each of which has specific advantages and disadvantages. This review article summarises the growth of PMFC technology, from its invention in 2014 until the present, with emphasis on fundamentals, fabrication methods, unit cell performance with various fuels, performance achievements, design considerations, and scale-up options. The applications and main challenges associated with the current status of the technology are provided along with future perspectives. Investigations in recent years have shown that PMFCs developed with different fuels enhance power density from several mu Wcm(-2) to several mWcm(-2) and that stacking multiple individual cells increases the working voltage. Moreover, enzymatic and microbial PMFCs show great potential to be used as wearable devices, sensors and in lab-on-chip devices. | Tanveer, Muhammad; Ambreen, Tehmina; Khan, Haroon; Kim, Gyu Man; Park, Cheol Woo | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Bukgu Daegu 41566, South Korea | Tanveer, MuhammadShahbaz/LUY-0421-2024 | 23486949200; 57195420431; 14521310700; 55664733000; 7408416474 | chwoopark@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 264 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2022 | 10.4 | 1.8 | 1.07 | 2025-06-25 | 41 | 47 | Paper-based microfluidic fuel cell; Fabric-based fuel cell; Screen-printed electrode; Point-of-care-testing; Assays; Lab-on-chip; Air-breathing; Mixing region; Depletion region | BIOFUEL CELL; HYDROGEN-PEROXIDE; PERFORMANCE ANALYSIS; FLUIDIC BATTERIES; POWER SOURCE; FLOW CELLS; ENERGY; STORAGE; GLUCOSE; ELECTRICITY | Air-breathing; Assays; Depletion region; Fabric-based fuel cell; Lab-on-chip; Mixing region; Paper-based microfluidic fuel cell; Point-of-care-testing; Screen-printed electrode | Biofuels; Laminar flow; Microfluidics; Nitrogen compounds; Paper; Phase interfaces; Air breathing; Depletion region; Fabric-based fuel cell; Lab-on-chips; Microfluidic fuel cell; Mixing region; Paper-based microfluidic fuel cell; Paper-based microfluidics; Point-of-care testing; Screen printed electrodes; Mixing | English | 2022 | 2022-07-15 | 10.1016/j.enconman.2022.115732 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Petasites japonicus extract exerts anti-malarial effects by inhibiting platelet activation | Background: New antimalarial agents are needed to combat emerging resistance to the currently available drugs. In the pathology of cerebral malaria, platelets play a central role by binding infected and uninfected red cells and the endothelium. Since Petasites japonicus extract was reported as an effective inhibitor of platelet activation, we examined the antimalarial activities of the P. japonicus extract. Purpose: This study aimed to evaluate the impact of P. japonicus extract prepared from whole plants on malarial infection. Methods: The P. japonicus extract were characterized by high-performance liquid chromatography (HPLC) profiling. Antimalarial activity of the P. japonicus ethanolic extract was evaluated in vitro using chloroquinesensitive (3D7) and chloroquine-resistant (Dd2) P. berghei strains. Also, the in vivo activity of the extract was evaluated in P. berghei-infected mice via oral administration followed by a four-day suppressive test to measure the hematological parameters. In addition, platelet activation signaling induced by the P. japonicus extract in P. berghei infection was evaluated. Results: : In HPLC study, catechin, rutin, liquiritin, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid were identified in P. japonicus extract. Exposure to the P. japonicus extract significantly inhibited both CQ-sensitive (3D7) and resistant (Dd2) strains of P. falciparum with IC50 values of 8.48 +/- 1.70 and 7.83 +/- 6.44 mu g/ml, respectively. Administration of the P. japonicus extract also resulted in potent antimalarial activities in P. berghei-infected mice with no associated toxicity. The treatment also improved the hematologic parameters. In addition, the survived mice from P. berghei infection exhibited the inhibition of collagen-induced platelet aggregation by attenuated glycopmtein VI (GPVI) downstream signaling. Conclusion: : P. japonicus extracts promote antimalarial effects both in vitro and in vivo. In addition, the effects appear to be induced by the inhibition of collagen-induced platelet activation related to attenuated GPVI downstream signaling. Further studies to identify and characterize the antimalarial compounds in P. japonicus will promote the development of new drugs. | Yun, Hae Soo; Dinzouna-Boutamba, Sylvatrie-Danne; Lee, Sanghyun; Moon, Zin; Kwak, Dongmi; Chung, Dong-Il; Hong, Yeonchul; Rhee, Man Hee; Goo, Youn-Kyoung | Kyungpook Natl Univ, Sch Med, Dept Parasitol & Trop Med, Daegu 41944, South Korea; Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Dept Precis Med, Div Bio Bigdata, Cheongju 28159, Chungbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Parasitol Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu 41566, South Korea | Rhee, Man/O-5705-2016 | 57194170243; 56299947300; 56272461500; 57223389298; 7007148758; 13310373300; 7403392847; 57211035357; 22937863200 | kuku1819@knu.ac.kr; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 102 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2022 | 7.9 | 1.8 | 0.24 | 2025-06-25 | 1 | 2 | Petasites japonicus; Plasmodium falciparum; Plasmodium berghei; Antimalarial effect; Platelet activation | CEREBRAL MALARIA; PLASMODIUM-FALCIPARUM; IN-VIVO; BRAIN; ADHESION; PROTECTS; MICE | Antimalarial effect; Petasites japonicus; Plasmodium berghei; Plasmodium falciparum; Platelet activation | Animals; Antimalarials; Chloroquine; Mice; Petasites; Plant Extracts; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; 3,4 di 2 caffeoylquinic acid; 3,5 di 2 caffeoylquinic acid; 4,5 di 2 caffeoylquinic acid; antimalarial agent; artemisinin; catechin; chloroquine; liquiritin; Petasites japonicus extract; plant extract; quinic acid; rutoside; unclassified drug; antimalarial agent; chloroquine; plant extract; animal cell; animal experiment; animal model; antimalarial activity; Article; clinical evaluation; controlled study; downstream processing; drug synthesis; female; hematological parameters; high performance liquid chromatography; IC50; in vitro study; malaria; mouse; nonhuman; Petasites; Petasites japonicus; Plasmodium berghei; Plasmodium berghei infection; Plasmodium falciparum; platelet reactivity; signal transduction; thrombocyte activation; thrombocyte aggregation; animal; chemistry; thrombocyte activation | English | 2022 | 2022-07-20 | 10.1016/j.phymed.2022.154167 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preliminary design and assessment of concentrated solar power plant using supercritical carbon dioxide Brayton cycles | In pursuit of efficient renewable electricity generation at a utility scale, concentrating solar power using receiver tower and heliostat field is one of the most prominent technologies due to its high achievable temperatures and environmental impact reduction. To increase the operating performance of this technology, innovative approaches have been focused on the heliostat field, thermal energy storage, and the integrated power cycle. Brayton cycles using supercritical carbon dioxide have emerged as an alternative to the traditional Rankine cycle for their compactness and superior performance even at extreme climate temperatures. In this work, a suite of code is developed to calculate expressively influencing parameters of the central receiver system, such as the exhaustive design of heliostat field pattern, characteristics angles, optical efficiency, and thermal energy storage, coupled with two Brayton cycle configurations. The seasonal effect on the performance of solar power plants is presented at different climatic conditions in terms of net power generation and cycle efficiency using the daily meteorological data. The year-round performance is assessed by statistically distributing the historical air temperature data into four categories. The proposed systems operate continually for 24 h with heat transfer fluid following a sinusoidal curved movement between the solar receiver and storage tanks. The findings demonstrate that the efficiency of the coupled system is higher with recompression cycle configuration while the fluctuation range is 39% to 45%. The computed mean net power output is 37.17 MW and 39.04 MW using regenerative and recompression cycles, respectively. The developed exhaustive methodology and computed results are of significance for future employment of supercritical carbon dioxide Brayton cycle for concentrated solar power plants. | Khatoon, Saboora; Kim, Man-Hoe | Kyungpook Natl Univ, Sch Mech Engn & IEDT, Daegu 41566, South Korea | 57197833125; 55686310000 | s.khatoon@knu.ac.kr;manhoe.kim@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 252 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2022 | 10.4 | 1.8 | 3.6 | 2025-06-25 | 45 | 49 | Supercritical carbon dioxide; Brayton cycle; Concentrated solar power; Heliostat field; Seasonal variation | HELIOSTAT FIELD LAYOUT; CO2; OPTIMIZATION; ENERGY | Brayton cycle; Concentrated solar power; Heliostat field; Seasonal variation; Supercritical carbon dioxide | Brayton cycle; Carbon dioxide; Digital storage; Environmental impact; Environmental technology; Heat storage; Heat transfer; Meteorology; Solar energy; Solar power plants; Thermal energy; Concentrated solar power; Heliostat field; Performance; Preliminary assessment; Preliminary design; Recompression cycles; Renewable electricity; Seasonal variation; Supercritical carbondioxides; Thermal energy storage; Supercritical fluid extraction | English | 2022 | 2022-01-15 | 10.1016/j.enconman.2021.115066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Multi-task vision transformer using low-level chest X-ray feature corpus for COVID-19 diagnosis and severity quantification | Developing a robust algorithm to diagnose and quantify the severity of the novel coronavirus disease 2019 (COVID-19) using Chest X-ray (CXR) requires a large number of well-curated COVID-19 datasets, which is difficult to collect under the global COVID-19 pandemic. On the other hand, CXR data with other findings are abundant. This situation is ideally suited for the Vision Transformer (ViT) architecture, where a lot of unlabeled data can be used through structural modeling by the self-attention mechanism. However, the use of existing ViT may not be optimal, as the feature embedding by direct patch flattening or ResNet backbone in the standard ViT is not intended for CXR. To address this problem, here we propose a novel Multi-task ViT that leverages low-level CXR feature corpus obtained from a backbone network that extracts common CXR findings. Specifically, the backbone network is first trained with large public datasets to detect common abnormal findings such as consolidation, opacity, edema, etc. Then, the embedded features from the backbone network are used as corpora for a versatile Transformer model for both the diagnosis and the severity quantification of COVID-19. We evaluate our model on various external test datasets from totally different institutions to evaluate the generalization capability. The experimental results confirm that our model can achieve state-of-the-art performance in both diagnosis and severity quantification tasks with outstanding generalization capability, which are sine qua non of widespread deployment. (c) 2021 Elsevier B.V. All rights reserved. | Park, Sangjoon; Kim, Gwanghyun; Oh, Yujin; Seo, Joon Beom; Lee, Sang Min; Kim, Jin Hwan; Moon, Sungjun; Lim, Jae-Kwang; Ye, Jong Chul | Korea Adv Inst Sci & Technol KAIST, Daejeon, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Daejeon, South Korea; Yeungnam Univ, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Oh, Yujin/ABG-2034-2020; Ye, Jong/C-1623-2011; Seo, Joon/AAQ-5445-2021 | 57211828373; 57222871620; 57218407478; 55512425800; 57203597198; 55910532600; 57189891980; 55515341400; 7403237499 | jong.ye@kaist.ac.kr; | MEDICAL IMAGE ANALYSIS | MED IMAGE ANAL | 1361-8415 | 1361-8423 | 75 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 10.9 | 1.9 | 8.5 | 2025-06-25 | 70 | 87 | Coronavirus disease-19; Chest X-ray; Vision transformer; Multi-task learning | Chest X-ray; Coronavirus disease-19; Multi-task learning; Vision transformer | COVID-19; COVID-19 Testing; Humans; Pandemics; SARS-CoV-2; X-Rays; Diagnosis; Large dataset; Back-bone network; Chest X-ray; Coronavirus disease-19; Coronaviruses; Generalization capability; Multi tasks; Robust algorithm; Unlabeled data; Vision transformer; X ray data; adult; Article; controlled study; coronavirus disease 2019; diagnostic accuracy; diagnostic test accuracy study; disease severity; feature extraction algorithm; female; ground glass opacity; human; lung consolidation; lung edema; major clinical study; male; middle aged; multitask vision transformer; quantitative analysis; sensitivity and specificity; thorax radiography; pandemic; X ray; Coronavirus | English | 2022 | 2022-01 | 10.1016/j.media.2021.102299 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Outcomes by baseline liver function in patients with unresectable hepatocellular carcinoma treated with tremelimumab and durvalumab in the phase 3 HIMALAYA study | Vogel, A.; Chan, S.; Furuse, J.; Tak, W.; Masi, G.; Varela, M.; Kim, J.; Tanasanvimon, S.; Reig, M.; Dayyani, F.; Makowsky, M.; Marcovitz, M.; Negro, A.; Abou-Alfa, G. | Med Hsch, Hannover, Germany; Chinese Univ Hong Kong, Sir Yue Kong Pao Ctr Canc, Hong Kong, Peoples R China; Kyorin Univ, Fac Med, Mitaka, Tokyo, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Univ Pisa, Azienda Osped Univ Pisana, Unit Med Oncol, Dept Translat Res & New Technol Med & Surg, Pisa, Italy; Univ Oviedo, Hosp Univ Cent Asturias, Oviedo, Spain; Seoul Natl Univ, Bundang Hosp, Coll Med, Seongnam, South Korea; Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Bangkok, Thailand; Barcelona Univ, Hosp Clin Barcelona, Barcelona Clin Liver Canc BCLC, Barcelona, Spain; Univ Calif Irvine, Irvine, CA USA; AstraZeneca, Gaithersburg, MD USA; Cornell Univ, Mem Sloan Kettering Canc Ctr, Weill Med Coll, New York, NY 10021 USA | Reig, Maria/ABB-5414-2021; Vogel, Arndt/A-8437-2012 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 33 | SCIE | ONCOLOGY | 2022 | 50.5 | 1.9 | 6 | English | 2022 | 2022-06 | 10.1016/j.annonc.2022.04.446 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | Phase 2 study of pembrolizumab-based combination therapy in patients with microsatellite instability-high or mismatch repair-deficient stage IV colorectal cancer | Andre, T.; Sposetti, C.; Gumus, M.; Ahn, J. Bae; Wyrwicz, L.; Kwiatkowski, M.; Kim, J.; Yalcin, S.; Sendur, M.; Odeleye-Ajakaye, A.; Leconte, P.; Fogelman, D.; Kim, T. | Hop St Antoine, Paris, France; Univ Milan, Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy; Istanbul Medeniyet Univ, Goztepe Prof Dr Suleyman Yalcin City Hosp, Istanbul, Turkey; Yonsei Univ Hlth Syst, Severance Hosp, Seoul, South Korea; Maria Sklodowska Curie Natl Res Inst Oncol, Warsaw, Poland; Szpital Wojewodzki Mikolaja Kopernika Koszalini, Koszalin, Poland; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Hacettepe Univ, Ankara, Turkey; Ankara Yildirim Beyazit Univ, Fac Med, Ankara, Turkey; Ankara City Hosp, Ankara, Turkey; Merck & Co Inc, Kenilworth, NJ USA; MSD France, Paris, Puteaux, France; Univ Ulsan, Med Ctr, Coll Med, Seoul, South Korea | Sposetti, Caterina/LFT-4451-2024; Sendur, Mehmet/H-7555-2014; André, Thierry/N-8830-2017; Kim, Dong-Wan/J-5391-2012 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 33 | SCIE | ONCOLOGY | 2022 | 50.5 | 1.9 | 0 | English | 2022 | 2022-06 | 10.1016/j.annonc.2022.04.118 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | Sequential afatinib and osimertinib in Asians with EGFRm plus NSCLC: combined analysis of two non-interventional studies | Miura, Satoru; Jung, Hyun Ae; Lee, Shin Yup; Lee, Seung Hyeun; Lee, Min Ki; Lee, Yong Chul; Hochmair, Maximilian J.; Yang, Cheng-Ta; Maerten, Angela; Yang, James Chih-Hsin; Popat, Sanjay | Niigata Canc Ctr Hosp, Dept Internal Med, Niigata, Japan; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyung Hee Univ, Sch Med, Med Ctr, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Chonbuk Natl Univ, Biomed Res Inst, Chonbuk Natl Univ Hosp, Dept Internal Med,Res Inst Clin Med, Jeonju, South Korea; Karl Landsteiner Inst Lung Res & Pulm Oncol, Dept Resp & Crit Care Med, Vienna, Austria; Chang Gung Mem Hosp, Dept Thorac Med, Taoyuan, Taiwan; Boehringer Ingelheim Int GmbH, Ingelheim, Germany; Natl Taiwan Univ, Dept Med Oncol, Ctr Canc, Taipei, Taiwan; Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan; Royal Marsden Natl Hlth Serv Fdn Trust, Lung Unit, London, England; Inst Canc Res, London, England | Yang, James/W-1587-2019; Park, Keunchil/ABD-5852-2021; LEE, Ji-Sun Lee/HTO-6715-2023; Popat, Sanjay/AAO-1634-2021; Schuler, Markus/AAI-6535-2020 | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 33 | SCIE | ONCOLOGY | 2022 | 50.5 | 1.9 | 0 | English | 2022 | 2022-07 | 10.1016/j.annonc.2022.05.177 | 바로가기 | 바로가기 | 바로가기 |
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