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| ○ | ○ | Article | Ginsenoside F2 induces cellular toxicity to glioblastoma through the impairment of mitochondrial function | Background: Glioblastoma (GBM) is the most aggressive tumor residing within the central nervous system, with extremely poor prognosis. Although the cytotoxic effects of ginsenoside F2 (GF2) on GBM were previously suggested, the precise anti-GBM mechanism of GF2 remains unclear. The aim of this study was to explore the anti-cancer molecular mechanism of GF2 toward human GBM. Methods: GF2-driven cellular toxicity was confirmed in two different GBM cells, U373 and Hs683. To test mitochondrial impairment driven by GF2, we examined the mitochondrial membrane potential, OCR, and ATP production. An intracellular redox imbalance was identified by measuring the relative ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), glutaredoxin (GLRX) mRNA expression, intracellular NAD+ level, and AMPK phosphorylation status. Results: GF2 increased the percentage of cleaved caspase 3-positive cells and gamma H2AX signal intensities, confirming that GF2 shows the cytotoxicity against GBM. GO enrichment analysis suggested that the mitochondrial function could be negatively influenced by GF2. GF2 reduced the mitochondrial membrane potential, basal mitochondrial respiratory rate, and ATP production capacity. Our results showed that GF2 downregulated the relative GSH/GSSG, intracellular NAD+ level, and GLRX expression, suggesting that GF2 may alter the intracellular redox balance that led to mitochondrial impairment. Conclusion: GF2 reduces mitochondrial membrane potential, inhibits cellular oxygen consumption, activates AMPK signaling, and induces cell death. Our study examined the potential vulnerability of mitochondrial activity in GBM, and this may hold therapeutic promise. | Kim, Tae-Jun; Kim, Hyeon Ji; Kang, Mingyu; Cho, Jin-Hwa; Kim, Yu Gyung; Lee, Sang Min; Byun, Jin-Seok; Kim, Do-Yeon | Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Brain Sci & Engn Inst, Dept Pharmacol, Daegu 41940, South Korea | Kim, Hee/AAU-6368-2021; Kim, Yong-Tae/HQZ-0240-2023; Kim, Do-Yeon/AET-3021-2022; Kim, Young-Bo/AAR-8052-2021 | 57200911346; 57216816929; 57204540968; 24167566000; 57221687604; 57213176293; 55430621800; 57203012542 | jsbyun@knu.ac.kr;dykim82@knu.ac.kr; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 83 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2021 | 6.656 | 1.7 | 1.21 | 2025-07-30 | 13 | 16 | Glioblastoma; Ginsenoside F2; Mitochondria | SUPEROXIDE-DISMUTASE; APOPTOSIS; PATHWAY; F-2 | Ginsenoside F2; Glioblastoma; Mitochondria | Antineoplastic Agents, Phytogenic; Caspase 3; Cell Death; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Ginsenosides; Glioblastoma; Glutaredoxins; Glutathione; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; antineoplastic agent; caspase 3; ginsenoside; ginsenoside f2; glutaredoxin; glutathione disulfide; histone H2AX; immunoglobulin enhancer binding protein; messenger RNA; nicotinamide adenine dinucleotide; unclassified drug; antineoplastic agent; CASP3 protein, human; caspase 3; ginsenoside; ginsenoside F2; GLRX protein, human; glutaredoxin; glutathione; AMPK signaling; antineoplastic activity; Article; cytotoxicity; disorders of mitochondrial functions; down regulation; drug mechanism; drug megadose; gene expression; glioblastoma; glioblastoma cell line; Hs 683 cell line; human; human cell; mitochondrial membrane potential; mitochondrial respiration; oxidation reduction potential; priority journal; protein expression; protein phosphorylation; cell death; drug effect; gene expression regulation; genetics; glioblastoma; metabolism; mitochondrion; oxidation reduction reaction; pathology; tumor cell line | English | 2021 | 2021-03 | 10.1016/j.phymed.2021.153483 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis | Accelerated glycolysis is the main metabolic change observed in cancer, but the underlying molecular mechanisms and their role in cancer progression remain poorly understood. Here, we show that the deletion of the long noncoding RNA (lncRNA) Neat1 in MMTV-PyVT mice profoundly impairs tumor initiation, growth, and metastasis, specifically switching off the penultimate step of glycolysis. Mechanistically, NEAT1 directly binds and forms a scaffold bridge for the assembly of PGK1/PGAM1/ENO1 complexes and thereby promotes substrate channeling for high and efficient glycolysis. Notably, NEAT1 is upregulated in cancer patients and correlates with high levels of these complexes, and genetic and pharmacological blockade of penultimate glycolysis ablates NEAT1-dependent tumorigenesis. Finally, we demonstrate that Pinin mediates glucose stimulated nuclear export of NEAT1, through which it exerts isoform-specific and paraspeckle-independent functions. These findings establish a direct role for NEAT1 in regulating tumor metabolism, provide new insights into the Warburg effect, and identify potential targets for therapy. | Park, Mi Kyung; Zhang, Li; Min, Kyung-Won; Cho, Jung-Hyun; Yeh, Chih-Chen; Moon, Hyesu; Hormaechea-Agulla, Daniel; Mun, Hyejin; Ko, Seungbeom; Lee, Ji Won; Jathar, Sonali; Smith, Aubrey S.; Yao, Yixin; Giang, Nguyen Thu; Ha Vu, Hong; Yan, Victoria C.; Bridges, Mary C.; Kourtidis, Antonis; Muller, Florian; Chang, Jeong Ho; Song, Su Jung; Nakagawa, Shinichi; Hirose, Tetsuro; Yoon, Je-Hyun; Song, Min Sup | Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA; Med Univ South Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA; Gangneung Wonju Natl Univ, Coll Nat Sci, Dept Biol, Gangneung Si 25457, Gangwon Do, South Korea; Soonchunhyang Univ, Soonchunhyang Inst Medi Bio Sci, Cheonan Si 31151, Chungcheongnam, South Korea; Natl Ctr Cell Sci, Lab IncRNA Biol, Pune 411007, Maharashtra, India; Kyungpook Natl Univ, Dept Biol Educ, Daegu 41566, South Korea; Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77030 USA; Med Univ South Carolina, Dept Regenerat Med & Cell Biol, Charleston, SC 29425 USA; Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan; Osaka Univ, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan | ; CHEN, YUFEI/KRO-7149-2024; Lee, Jeeyun/I-7171-2015; Park, Mi-Kyung/J-9643-2017; Nakagawa, Shinichi/I-4192-2014; Cyan, Victoria/HGU-5980-2022 | 57193155495; 57250043300; 54417697400; 56650401200; 57360730800; 57201528943; 55964196900; 57216672802; 57212308322; 57221527784; 57195409824; 57195929866; 8955381400; 57360149700; 57222482871; 57203805547; 56754801300; 8672063000; 7402078338; 57203598905; 12786504900; 7402703498; 7402601984; 55318967100; 35328061300 | yoonje@musc.edu;msong1@mdanderson.org; | CELL METABOLISM | CELL METAB | 1550-4131 | 1932-7420 | 33 | 12 | SCIE | CELL BIOLOGY;ENDOCRINOLOGY & METABOLISM | 2021 | 31.373 | 1.7 | 7.64 | 2025-07-30 | 131 | 134 | LONG NONCODING RNAS; LOCALIZATION; PARASPECKLES; REVEALS; PROGRESSION; ACTIVATION; EXPRESSION; PREDICTION; ISOFORM; TUMORS | aerobic glycolysis; breast cancer; ENO1; long noncoding RNA; NEAT1; PGAM1; PGK1; Pinin; tumor metabolism; Warburg effect | Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Mice; MicroRNAs; RNA, Long Noncoding; long noncoding RNA neat1; long untranslated RNA; unclassified drug; long untranslated RNA; microRNA; adult; animal experiment; animal model; Article; binding affinity; breast cancer; breast tumor; cancer growth; cancer patient; carcinogenesis; controlled study; correlation analysis; female; glycolysis; metabolism; metastasis in breast; mouse; nonhuman; nuclear export; tumor metabolism; upregulation; Warburg effect; animal; breast tumor; cell proliferation; gene expression regulation; genetics; human; metabolism; tumor cell line | English | 2021 | 2021-12-07 | 10.1016/j.cmet.2021.11.011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Protective effects of Phlomis umbrosa extract on a monosodium iodoacetate induced osteoarthritis model and prediction of molecular mechanisms using transcriptomics | Background: Phlomis umbrosa Turczaninow root has been traditionally used to treat fractures, rheumatoid arthritis, and arthralgia. However, the effects and mechanisms of P. umbrosa on osteoarthritis (OA) remain poorly understood and a functional genomic approach has not been investigated. Aim: The purpose of this study was to investigate the effects and mechanisms of P. umbrosa extract (PUE) on OA using transcriptomic analysis. Methods: We performed joint diameter measurements, micro computed tomography, and histopathological analysis of monosodium iodoacetate (MIA)-induced OA rats treated with PUE (200 mg/kg) for 3 weeks. Gene expression profiling in articular cartilage tissue was then performed using RNA sequencing (RNA-seq) followed by signaling pathway analysis of regulatory genes. Results: PUE treatment improved OA based on decreased joint diameter, increased joint morphological parameters, and histopathological features. Many genes involved in multiple signal transduction pathway and collagen activation in OA were differentially regulated by PUE. These included genes related to Wnt/p-catenin, OA pathway, and sonic hedgehog signaling activity. Furthermore, PUE treatment downregulated cartilage damage factors (MMP-9, MMP-13, ADAMTs4, and ADMATs5) and upregulated chondrogenesis (COL2A1 and SOX-9) by regulating the transcription factors SOX-9, Ctnnbl, and Epasl. Conclusion: Based on the results of gene expression profiling, this study highlighted the molecular mechanisms underlying the effects of PUE in MIA-induced OA rats. The findings provide novel insight into the mechanisms by which PUE treatment-induced gene expression changes may influence OA disease progression. Taken together, the results suggest that PUE may be used as a source of therapeutic agents for OA. | Chun, Jin Mi; Lee, A. Yeong; Nam, Jae Yong; Lee, Min Young; Choe, Mu Seog; Lim, Kyung Seob; Kim, Chul; Kim, Joong-Sun | Korea Inst Oriental Med, Herbal Med Resources Res Ctr, 111 Geonjae Ro, Naju 58245, Jeollanam Do, South Korea; Sookmyung Womens Univ, Dept Life Syst, Seoul, South Korea; Insilicogen Corp, Bioinformat Grp, R&D Ctr, Yongin, South Korea; Kyungpook Natl Univ, Coll Pharm, Dept Mol Physiol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Cheongju, Chungbuk, South Korea; Korea Inst Oriental Med, Future Med Div, Daejeon, South Korea | Lee, Hye/D-9081-2016; Lee, A Yeong/ABP-3962-2022 | 8146963000; 7405631098; 57220811305; 15119890400; 57202926165; 36470521900; 56014161800; 7601371367 | chulnice@kiom.re.kr;centraline@kiom.re.kr; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 81 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2021 | 6.656 | 1.7 | 1.51 | 2025-07-30 | 19 | 20 | Phlomis umbrosa extract (PUE); Osteoarthritis (OA); monosodium iodoacetate (MIA)-induced rat; RNA sequencing (RNAseq) | EXPRESSION; CARTILAGE; PAIN; REGULATOR; STRINGTIE; JOINT; SOX9 | monosodium iodoacetate (MIA)-induced rat; Osteoarthritis (OA); Phlomis umbrosa extract (PUE); RNA sequencing (RNA-seq) | Animals; Cartilage, Articular; Chondrogenesis; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Iodoacetates; Joints; Male; Osteoarthritis; Phlomis; Plant Extracts; Rats, Sprague-Dawley; X-Ray Microtomography; aggrecanase 1; antirheumatic agent; beta catenin; collagen type 2; collagenase 3; hypoxia inducible factor 2alpha; iodoacetic acid; Phlomis umbrosa extract; plant extract; sonic hedgehog protein; transcription factor Sox9; unclassified drug; Wnt protein; iodoacetic acid; plant extract; animal experiment; animal model; animal tissue; Article; articular cartilage; chondrogenesis; controlled study; drug effect; drug mechanism; enzyme activity; gene expression profiling; histopathology; male; micro-computed tomography; nonhuman; osteoarthritis; Phlomis; Phlomis umbrosa; priority journal; rat; regulator gene; RNA sequencing; signal transduction; transcriptomics; animal; chemistry; disease model; drug effect; gene expression regulation; genetics; joint; osteoarthritis; pathology; Phlomis; Sprague Dawley rat | English | 2021 | 2021-01 | 10.1016/j.phymed.2020.153429 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Quercitrin inhibits platelet activation in arterial thrombosis | Background: The ingestion of flavonoids has been reported to be associated with reduced cardiovascular disease risk. Quercitrin is a common flavonoid in nature, and it exhibits antioxidant properties. Although the process of thrombogenesis is intimately related to cardiovascular disease risk, it is unclear whether quercitrin plays a role in thrombogenesis. Purpose: The aim of this study was to examine the antiplatelet effect of quercitrin in platelet activation. Methods: Platelet aggregation, granule secretion, calcium mobilization, and integrin activation were used to assess the antiplatelet activity of quercitrin. Antithrombotic effect was determined in mouse using ferric chloride (FeCl3)-induced arterial thrombus formation in vivo and thrombus formation on collagen-coated surfaces under arteriolar shear in vitro. Transection tail bleeding time was used to evaluate whether quercitrin inhibited primary hemostasis. Results: Quercitrin significantly impaired collagen-related peptide-induced platelet aggregation, granule secretion, reactive oxygen species generation, and intracellular calcium mobilization. Outside-in signaling of allbp3 integrin was significantly inhibited by quercitrin in a concentration-dependent manner. The inhibitory effect of quercitrin resulted from inhibition of the glycoprotein VI-mediated platelet signal transduction during cell activation. Further, the antioxidant effect is derived from decreased phosphorylation of components of the TNF receptor-associated factor 4/p47(phox)/Hic5 axis signalosome. Oral administration of quercitrin efficiently blocked FeCl3-induced arterial thrombus formation in vivo and thrombus formation on collagen-coated surfaces under arteriolar shear in vitro, without prolonging bleeding time. Studies using a mouse model of ischemia/reperfusion-induced stroke indicated that treatment with quercitrin reduced the infarct volume in stroke. Conclusions: Our results demonstrated that quercitrin could be an effective therapeutic agent for the treatment of thrombotic diseases. | Oh, Tae Woo; Do, Hyun Ju; Jeon, Jae-Han; Kim, Kyungho | Korea Inst Oriental Med, Korean Med Applicat Ctr, 70 Cheomdanro Dong Gu, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea | 37047501300; 46461128400; 36910340400; 58612234300 | jk6012@kiom.re.kr; | PHYTOMEDICINE | PHYTOMEDICINE | 0944-7113 | 1618-095X | 80 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2021 | 6.656 | 1.7 | 3.63 | 2025-07-30 | 37 | 41 | Platelet; Thrombosis; Quercitrin; Flavonoids; Glycoprotein VI | SUPEROXIDE ANION; GLYCOPROTEIN-VI; ROS PRODUCTION; COLLAGEN; QUERCETIN; FLAVONOIDS; RELEASE; PATHWAY; DISEASE; LIPOPOLYSACCHARIDE | Flavonoids; Glycoprotein VI; Platelet; Quercitrin; Thrombosis | Adenosine Triphosphate; Animals; Arteries; Calcium; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemostasis; Humans; Male; Mice, Inbred C57BL; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Quercetin; Reperfusion Injury; Thrombosis; adenosine triphosphate; alpha2 integrin; antioxidant; collagen; ferric chloride; fibrinogen; glycoprotein VI; integrin; integrin alpha2beta3; PADGEM protein; protein tyrosine kinase; quercitrin; reactive oxygen metabolite; tumor necrosis factor receptor associated factor 4; unclassified drug; adenosine triphosphate; antithrombocytic agent; calcium; fibrinogen receptor; fibrinolytic agent; platelet membrane glycoprotein VI; quercetin; quercitrin; animal cell; animal experiment; animal model; antiplatelet activity; antithrombotic activity; artery thrombosis; Article; bleeding time; blood clotting; brain infarction size; calcium cell level; calcium mobilization; cell activation; cerebral ischemia reperfusion injury; cerebrovascular accident; controlled study; enzyme phosphorylation; flow cytometry; focal adhesion; hemostasis; human; human cell; male; mouse; nonhuman; pathogenesis; priority journal; signal transduction; tail bleeding time; thrombocyte activation; thrombocyte aggregation; animal; artery; C57BL mouse; dose response; drug effect; metabolism; phosphorylation; reperfusion injury; thrombocyte activation; thrombocyte aggregation; thrombosis | English | 2021 | 2021-01 | 10.1016/j.phymed.2020.153363 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CFD aided design and analysis of a precooler with zigzag channels for supercritical CO2 power cycle | Printed circuit heat exchangers (PCHEs) with zigzag channel geometry have frequently been investigated under recuperator conditions (0.7 < Pr < 2.2) of the supercritical carbon dioxide Brayton Cycle (sCO2 -BC). However, the characteristics of the zigzag channel under precooler conditions (1 < Pr < 20) of sCO2 -BC are still unclear. For this reason, a 3D Reynolds Averaged Navier?Stokes (RANS) model is developed and validated to scrutinize the impact of various parameters on the design of precooler of sCO2 -BC using zigzag channels. To ensure the accuracy of the numerical model, sharp variations in the thermo-physical properties of carbon dioxide are incorporated by providing high-resolution real gas property (RGP) tables to the solver. Additionally, a new data reduction method is devised and implemented to account for the adverse variations in carbon dioxide?s thermophysical properties. Obtained results suggest that choosing smaller design point values for channel mass flow rates of CO2 reduce the pressure losses significantly; however, the consequent temperature profiles can draw the undesirable pinch point location inside the heat exchanger. Although pinch points can be avoided for precooler using higher channel mass flow rates, such designs are incredibly compact and exhibit poor hydraulic performance. Furthermore, it was found that pressure losses at the cold side were significantly higher in comparison with the hot side. However, it is shown that the hydraulic performance of the cold side can be improved substantially using sandwiched channel configuration without compromising the thermal characteristics of the precooler. | Saeed, Muhammed; Awais, Ahmad Ali; Berrouk, Abdallah S. | Khalifa Univ Sci & Technol, Mech Engn Dept, POB 127788, Abu Dhabi, U Arab Emirates; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Khalifa Univ Sci & Technol, Ctr Catalysis & Separat CeCas, POB 127788, Abu Dhabi, U Arab Emirates | ; Saeed, Muhammad/R-4401-2019 | 56513270400; 57218293222; 15750216900 | muhammed.saeed1@ku.ac.ae; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 236 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2021 | 11.533 | 1.8 | 4.07 | 2025-07-30 | 66 | 68 | Brayton Cycle; Precooler design; Zigzag channel; Printed circuit heat exchanger | CIRCUIT HEAT-EXCHANGER; PERFORMANCE; FLOW | Brayton Cycle; Precooler design; Printed circuit heat exchanger; Zigzag channel | Brayton cycle; Carbon dioxide; Computational fluid dynamics; Mass transfer; Printed circuits; Supercritical fluid extraction; Thermodynamic properties; Brayton; Condition; Hydraulic performance; Mass-flow rate; Pinch points; Pre-cooler; Precooler design; Pressure loss; Printed circuit heat exchangers; Zigzag channel; Heat exchangers | English | 2021 | 2021-05-15 | 10.1016/j.enconman.2021.114029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Letter | Characterization of asthma and risk factors for delayed SARS-CoV-2 clearance in adult COVID-19 inpatients in Daegu | Kim, Sujeong; Jung, Chang-Gyu; Lee, Ji Yeon; Kim, Gunwoo; Choi, Sae Won; Jin, Hyun Jung; Park, Han-Ki | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Div Allergy & Clin Immunol, Dept Internal Med,Sch Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Div Allergy & Clin Immunol, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Div Infect Dis, Daegu, South Korea; Fatima Hosp, Dept Internal Med, Div Allergy & Rheumatol, Daegu, South Korea; Seoul Natl Univ Hosp, Off Hosp Informat, Seoul, South Korea; Yeungnam Univ, Sch Med, Dept Internal Med, 170 Hyeonchung Ro, Daegu 42415, South Korea | Park, Han-Ki/AAY-3102-2020; Jin, Hyunjung/MHR-8031-2025; Kim, Ju-Hyoung/N-1450-2019 | 36666447400; 57191478350; 57216774221; 57206754090; 56124321400; 36157127500; 57218664064 | jhj0619@yu.ac.kr;haan33@gmail.com; | ALLERGY | ALLERGY | 0105-4538 | 1398-9995 | 76 | 3 | SCIE | ALLERGY;IMMUNOLOGY | 2021 | 14.71 | 1.8 | 2.29 | 2025-07-30 | 14 | 17 | asthma; COVID-19; negative conversion; prevalence; risk factor; SARS-CoV-2 | asthma; COVID-19; negative conversion; prevalence; risk factor; SARS-CoV-2 | Adult; Age Factors; Aged; Asthma; COVID-19; Female; Humans; Male; Middle Aged; Risk Factors; SARS-CoV-2; Time Factors; Virus Shedding; Young Adult; C reactive protein; hemoglobin; hypertensive agent; inotropic agent; oxygen; adult; age; aged; asthma; autoimmune disease; chronic kidney failure; chronic obstructive lung disease; clinical feature; clinical outcome; controlled study; coronavirus disease 2019; COVID-19 nucleic acid testing; dementia; diabetes mellitus; disease severity; dyspnea; extracorporeal oxygenation; female; headache; hemoglobin blood level; hospital patient; human; hypertension; infection risk; Letter; major clinical study; male; malignant neoplasm; mental disease; middle aged; mortality rate; mortality risk; nausea and vomiting; obesity; oxygen therapy; prevalence; priority journal; protein blood level; rash; real time reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; sex difference; South Korea; viral clearance; asthma; complication; isolation and purification; mortality; risk factor; time factor; virology; virus shedding; young adult | English | 2021 | 2021-03 | 10.1111/all.14609 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Combination treatment of copanlisib and gemcitabine in relapsed refractory PTCL (COSMOS): an open-label phase I/II trial | Background: Current treatment options for peripheral T-cell lymphomas (PTCLs) in the relapsed/refractory setting are limited and demonstrate modest response rates with rare achievement of complete response (CR). Patients and methods: This phase I/II study (NCT03052933) investigated the safety and efficacy of copanlisib, a phosphatidylinositol 3-kinase-alpha/-delta inhibitor, in combination with gemcitabine in 28 patients with relapsed/refractory PTCL. Patients received escalating doses of intravenous copanlisib on days 1, 8, and 15, administered concomitantly with fixed-dose gemcitabine (1000 mg/m(2) on days 1 and 8) in 28-day cycles. Results: Dose-limiting toxicity was not observed in the dose-escalation phase and 60 mg copanlisib was selected for phase II evaluation. Twenty-five patients were enrolled in phase II of the study. Frequent grade >= 3 adverse events (AEs) included transient hyperglycemia (57%), neutropenia (45%), thrombocytopenia, (37%), and transient hypertension (19%). However, AEs were manageable, and none were fatal. The overall response rate was 72% with a CR rate of 32%. Median duration of response was 8.2 months, progression-free survival was 6.9 months, and median overall survival was not reached. Combination treatment produced a greater CR rate in patients with angioimmunoblastic T-cell lymphoma than those with PTCL-not otherwise specified (55.6% versus 15.4%, respectively, P = 0.074) and progression-free survival was significantly longer (13.0 versus 5.1 months, respectively, P = 0.024). In an exploratory gene mutation analysis of 24 tumor samples, TSC2 mutation was present in 25% of patients and occurred exclusively in responders. Conclusion: The combination of copanlisib and gemcitabine is a safe and effective treatment option in relapsed/ refractory PTCLs and represents an important new option for therapy in this rare group of patients. | Yhim, H-Y; Kim, T.; Kim, S. J.; Shin, H-J; Koh, Y.; Kim, J. S.; Park, J.; Park, G. S.; Kim, W. S.; Moon, J. H.; Yang, D-H | Jeonbuk Natl Univ, Med Sch, Dept Internal Med, Jeonju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju, South Korea; Chonnam Natl Univ, Dept Med Sci, Med Sch, Jeollanam Do, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; Catholic Univ Korea, Coll Med, Dept Pathol, Seoul St Marys Hosp, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, 130 Dongdeok Ro, Daegu 41944, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeollanam Do, South Korea | KIM, JIN/I-6927-2019; Kim, HJ/HHT-1389-2022; Jung, SeungHyun/HTS-1049-2023 | 35785270600; 56427191400; 36521373300; 16239868400; 56450114900; 55032033600; 35277336100; 8406567900; 57977785900; 56568642700; 8701758000 | jhmoon@knu.ac.kr;drydb1685@hotmail.com;drydh1685@hotmail.com; | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 32 | 4 | SCIE | ONCOLOGY | 2021 | 51.769 | 1.8 | 1.13 | 2025-07-30 | 22 | 22 | copanlisib; gemcitabine; peripheral T-cell lymphoma; relapsed or refractory; phase I/II trial | PERIPHERAL T-CELL; LYMPHOMA; INHIBITION; CARCINOMA; CISPLATIN; 3-KINASE; PATHWAY; PI3K; AKT | copanlisib; gemcitabine; peripheral T-cell lymphoma; phase I/II trial; relapsed or refractory | Deoxycytidine; Humans; Lymphoma, T-Cell, Peripheral; Neoplasm Recurrence, Local; Pyrimidines; Quinazolines; Treatment Outcome; antihypertensive agent; antineoplastic agent; copanlisib; cotrimoxazole; gemcitabine; insulin; tuberin; copanlisib; deoxycytidine; gemcitabine; pyrimidine derivative; quinazoline derivative; adult; aged; angioimmunoblastic t cell lymphoma; Article; cancer combination chemotherapy; cancer patient; cancer recurrence; clinical article; drug dose escalation; drug dose reduction; drug efficacy; drug megadose; drug safety; drug withdrawal; fatigue; female; gene mutation; herpes zoster; human; human tissue; hyperglycemia; hypertension; infection; male; maximum tolerated dose; multicenter study; multiple cycle treatment; mutational analysis; neutropenia; open study; overall survival; peripheral T cell lymphoma; phase 1 clinical trial; phase 2 clinical trial; progression free survival; survival time; thrombocytopenia; treatment response; TSC2 gene; virus pneumonia; clinical trial; drug therapy; peripheral T cell lymphoma; treatment outcome; tumor recurrence | English | 2021 | 2021-04 | 10.1016/j.annonc.2020.12.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | eAssociation between nonalcoholic fatty liver disease and the incidence of asthma in adults: results from the korean national health insurance service-national sample cohort (NHIS-NSC) database | Roh, J.; Lee, H.; Bae, Y.; Park, C. S.; Kim, H.; Yoon, S. | Chungnam Natl Univ, Sejong Hosp, Sejong, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Asan Med Ctr, Asan Inst Life Sci, Hlth Innovat Bigdata Ctr, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Busan, South Korea; Chungnam Natl Univ, Sejong Hosp, Sejong, South Korea | ALLERGY | ALLERGY | 0105-4538 | 1398-9995 | 76 | SCIE | ALLERGY;IMMUNOLOGY | 2021 | 14.71 | 1.8 | 0 | English | 2021 | 2021-11 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | ○ | Article | Modeling and analysis of air-cooled heat exchanger integrated with supercritical carbon dioxide recompression Brayton cycle | This paper investigates the thermal performance of the recompression supercritical carbon dioxide power cycle integrated with a direct air-cooled heat exchanger. The desirable attributes for economical concentrated solar power plants are their integration ability with thermal energy storage and to accommodate dry cooling. The expressively influencing parameters such as compressor inlet temperature, pressure, and split mass fraction have been investigated for cycle maximum efficiency under arid climatic conditions. The cooling process of supercritical carbon dioxide, unlike steam condensation, is sensible heat transfer with the non-linear variation of thermophysical properties. Effective, efficient, and affordable heat exchanger technology is crucial for the deployment of supercritical carbon dioxide Brayton power cycles in concentrated solar power plants. A MATLAB code has been developed for an air-cooled heat exchanger with multi-pass sub heat exchanger approach to overcome the inevitable temperature variations at the extreme end of the gas cooler. A two dimensional discretization methodology is used to model the heat exchanger to accommodate the rapidly varying isobaric heat capacity in the critical temperature region. The heat transfer and pressure drop performance are calculated using empirical correlations for the Nusselt number and friction factor for each sub-heat exchanger. With the increased contact time of cooling and process fluid, the desired gas cooler outlet temperature of 33.5 degrees C is achieved by rejecting 823.76 kW, 359.5 kW, and 219.46 kW amount of heat from each sub-heat exchanger, respectively. The results of this work are of significance for the design of the air-cooled heat exchanger for the supercritical carbon dioxide power generation system. | Khatoon, Saboora; Ishaque, Shehryar; Kim, Man-Hoe | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, IEDT, Daegu 41566, South Korea | 57197833125; 57212480549; 55686310000 | manhoe.kim@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 232 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2021 | 11.533 | 1.8 | 1.74 | 2025-07-30 | 31 | 30 | Supercritical carbon dioxide; recompression Brayton cycle; Air-cooled heat exchanger; Heat transfer; Pressure drop | POWER-GENERATION; CO2; PERFORMANCE; SYSTEM | Air-cooled heat exchanger; Heat transfer; Pressure drop; recompression Brayton cycle; Supercritical carbon dioxide | Brayton cycle; Carbon dioxide; Carbon dioxide process; Cooling systems; Heat storage; Heat transfer performance; MATLAB; Solar power plants; Specific heat; Steam condensers; Supercritical fluid extraction; Temperature; Air-cooled heat exchanger; Concentrated solar power; Critical temperature region; Heat exchanger technology; Heat transfer and pressure drop; Isobaric heat capacity; Power generation systems; Supercritical carbon dioxides; Heat exchangers | English | 2021 | 2021-03-15 | 10.1016/j.enconman.2021.113895 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Sequential afatinib (afa) and osimertinib (osi) in patients (pts) with advanced EGFR mutation-positive (EGFRm plus ) NSCLC who acquire the T790M resistance mutation: A non-interventional cohort study (UpSwinG) | Popat, S.; Jung, H. A.; Lee, S. Yup; Hochmair, M. J.; Lee, S. H.; Escriu, C.; Lee, M. K.; Migliorino, M. R.; Lee, Y. C.; Girard, N.; Daoud, H.; Maerten, A.; Miura, S. | Royal Marsden Natl Hlth Serv Fdn Trust, Lung Unit, London, England; Inst Canc Res, London, England; Sungkyunkwan Univ, Div Hematol Oncol, Dept Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Karl Landsteiner Inst Lung Res & Pulm Oncol, Dept Resp & Crit Care Med, Vienna, Austria; Kyung Hee Univ, Med Ctr, Div Pulm & Crit Care Med, Dept Internal Med,Sch Med, Seoul, South Korea; Clatterbridge Canc Ctr, Thorac Med Oncol, Bebington, Wirral, Merseyside, England; Pusan Natl Univ, Dept Internal Med, Sch Med, Busan, South Korea; San Camillo Forlanini Hosp, Pulm Oncol Unit, Rome, Italy; Chonbuk Natl Univ, Res Inst Clin Med, Chonbuk Natl Univ Hosp, Dept Internal Med,Med Sch,Biomed Res Inst, Jeonju, South Korea; Inst Curie, Inst Thorax Curie Montsouris, Thorac Surg, Paris, France; Boehringer Ingelheim Int GmbH, Clin Trials, Ingelheim, Germany; Boehringer Ingelheim Int GmbH, TA Oncol Med, Ingelheim, Germany; Niigata Canc Ctr Hosp, Dept Internal Med, Niigata, Japan | ANNALS OF ONCOLOGY | ANN ONCOL | 0923-7534 | 1569-8041 | 32 | SCIE | ONCOLOGY | 2021 | 51.769 | 1.8 | 1 | English | 2021 | 2021 | 10.1016/j.annonc.2021.08.1828 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | The clinical burden in systemic corticosteroid-independent asthmatics with high blood eosinophil counts: COREA cohort in Korea | Kim, M.; Jo, E.; Kim, S.; Kim, M.; Jung, J.; Kim, J.; Moon, J.; Kwon, J. W.; Lee, J.; Park, C.; Shin, Y. S.; Jin, H. J.; Kim, S.; Cho, Y.; Park, J.; Cho, S.; Kim, T.; Park, H. | Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Coll Med, Anyang, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Guri, South Korea; Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; Yonsei Univ, Div Allergy & Immunol, Dept Internal Med, Coll Med, Chunchon, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Yonsei Univ, Div Allergy & Immunol, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Univ Ulsan, Dept Allergy & Clin Immunol, Asan Med Ctr, Coll Med, Seoul, South Korea | Kim, Hye/AAF-7609-2020; Jin, Hyunjung/MHR-8031-2025; Kim, Sara/F-2951-2013; Lee, Jae-Hyun/ABE-3803-2020; Lee, Jinseok/ACF-1247-2022 | ALLERGY | ALLERGY | 0105-4538 | 1398-9995 | 76 | SCIE | ALLERGY;IMMUNOLOGY | 2021 | 14.71 | 1.8 | 0 | English | 2021 | 2021-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Comparative study of tensile and high-cycle fatigue properties of extruded AZ91 and AZ91-0.3Ca-0.2Y alloys | Mg-Al-Zn-Ca-Y alloys with excellent ignition and corrosion resistances-termed SEN alloys (where the letters "S," "E," and "N" stand for stainless, environmentally friendly, and non-flammable, respectively)- have been developed recently. In this study, the microstructure, tensile properties, and high-cycle fatigue properties of an extruded Mg-9.0Al-0.8Zn-0.1Mn-0.3Ca-0.2Y (SEN9) alloy are investigated and compared with those of a commercial Mg-9.0Al-0.8Zn-0.1Mn (AZ91) alloy extruded under the same conditions. Both the extruded SEN9 alloy and the extruded AZ91 alloy have a fully recrystallized structure comprising equiaxed grains, but the former has a smaller average grain size owing to the promoted dynamic recrystallization during extrusion. The extruded AZ91 alloy contains coarse Mg17Al12 discontinuous precipitate (DP) bands parallel to the extrusion direction, which are formed during its cool down after extrusion. In contrast, the extruded SEN9 alloy contains relatively fine undissolved Al2Ca, Al8Mn4Y, and Al2Y second-phase particles, which are formed during the solidification stage of the casting process. The tensile strength of the extruded SEN9 alloy, which has finer grains and more abundant particles, is slightly higher than that of the extruded AZ91 alloy. However, the difference in their strengths is relatively small because the stronger solid-solution hardening and precipitation hardening effects in the extruded AZ91 alloy offset the stronger grain-boundary hardening and dispersion hardening effects in the extruded SEN9 alloy to some extent. The tensile elongation of the extruded AZ91 alloy is significantly lower than that of the extruded SEN9 alloy because the large cracks formed in the DP bands in the former cause its premature fracture. Although the extruded SEN9 alloy has higher tensile properties than the extruded AZ91 alloy, the high-cycle fatigue life and fatigue strength of the former are shorter and lower, respectively, than those of the latter. The DP bands in the extruded AZ91 alloy do not act as fatigue crack initiation sites, and therefore, fatigue cracks initiate on the specimen surface at all stress amplitude levels. In contrast, in most of the fatigue-fractured specimens of the extruded SEN9 alloy, fatigue cracks initiate on the undissolved Al2Ca and Al2Y particles present on the surface or subsurface of the specimens because of the high local stress concentration on the particles during cyclic loading. This particle-initiated fatigue fracture eventually decreases the high-cycle fatigue resistance of the extruded SEN9 alloy. (C) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals. | Kim, Ye Jin; Kim, Young Min; Hong, Seong-Gu; Kim, Dae Woong; Lee, Chong Soo; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Implementat Res Div, Chang Won 51508, South Korea; Korea Res Inst Stand & Sci, Div Ind Metrol, Daejeon 34113, South Korea; Korea Res Inst Stand & Sci, Energy Infra Mat Measure Team, Daejeon 34113, South Korea; Pohang Univ Sci & Technol, Grad Inst Ferrous Technol, Pohang 37673, South Korea | Park, Sung-Hyuk/AAE-6726-2022; Kim, Young Min/HCH-5414-2022; Lee, Chong Soo/D-4431-2011 | 59052467200; 58795669000; 35324234600; 57293041500; 26028614900; 54786002500 | sh.park@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 93 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 10.32 | 1.9 | 1.81 | 2025-07-30 | 12 | 27 | Mg-Al-Zn-Ca-Y alloy; Extrusion; Tensile properties; High-cycle fatigue; Crack source | MECHANICAL-PROPERTIES; MAGNESIUM ALLOY; CORROSION-RESISTANCE; MICROSTRUCTURAL EVOLUTION; GRAIN-SIZE; BEHAVIOR; PRECIPITATION; TEMPERATURE; EXTRUSION; MICRO | Crack source; Extrusion; High-cycle fatigue; Mg–Al–Zn–Ca–Y alloy; Tensile properties | Age hardening; Aluminum alloys; Aluminum corrosion; Binary alloys; Calcium alloys; Corrosion resistance; Cracks; Dispersion hardening; Dynamic recrystallization; Extrusion; Fatigue crack propagation; Fracture; Grain boundaries; Magnesium alloys; Manganese alloys; Precipitation (chemical); Stress analysis; Tensile strength; Ternary alloys; Textures; Comparative studies; Discontinuous precipitates; Fatigue crack initiation; Grain boundary hardening; High cycle fatigue properties; Local stress concentration; Second phase particles; Solid solution hardening; Fatigue of materials | English | 2021 | 2021-12-10 | 10.1016/j.jmst.2021.03.039 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Development of a New Risk Stratification System for Patients with Newly Diagnosed Multiple Myeloma Using R-ISS and 18F-FDG PET/CT | Cho, Hee Jeong; Kim, Juhyung; Lee, Jung Min; Baek, Dong Won, Sr.; Jung, Sung-Hoon; Yoon, Sang Eun; Park, Sung-Soo; Kim, Do Young; Shin, Ho-Jin; Mun, Yeung-Chul; Yi, Jun Ho; Kim, Hyo Jung; Kim, Da Jung; Lee, Ho Sup; Bae, Sung Hwa; Sohn, Sang Kyun; Min, Chang-Ki; Kim, Kihyun; Lee, Je-Jung; Lee, Yoo Jin; Jo, Jae-Cheol; Moon, Joon Ho | Kyungpook Natl Univ Hosp, Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Hematol Oncol, Daegu, South Korea; Chonnam Natl Univ Hwasun Hosp, Hwasun, South Korea; Sungkyunkwan Univ, Div Hematol Oncol, Dept Internal Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Cathol Hematol Hosp, Dept Hematol,Coll Med, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst, Dept Hematol Oncol,Sch Med, Busan, South Korea; Busan Natl Univ Hosp, Busan, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Ewha Womans Univ, Dept Hematol, Seoul, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea; Hallym Univ Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea; Kosin Univ, Gosper Hosp, Pusan, South Korea; Kosin Univ, Div Hematol Oncol, Dept Internal Med, Gospel Hosp, Busan, South Korea; Daegu Catholic Univ, Dept Hematol Oncol, Med Ctr, Daegu, South Korea; Daegu Catholic Nivers Med Ctr, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; Seoul St Marys Hosp, Seoul, South Korea; Sungkyunkwan Univ, Div Hematol Oncol, Dept Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; Chonnam Natl Univ, Dept Hematol Oncol, Hwasun Hosp, Gwangju, Jeollanam Do, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea | Yi, Jun Ho/GXZ-8144-2022; Lee, Jung-Min/L-8227-2016; Lee, Jong-Seok/J-5603-2012; Kim, Kihyun/D-5175-2013; Jo, Jae-Cheol/CAE-9453-2022; Hyun-Jung, Kim/E-8074-2011; Kim, Jwa/AAH-9915-2021; Lee, Jung-Hye/F-6974-2013; Kim, Hyo/AAQ-3152-2020; KIM, JIN/I-6927-2019 | BLOOD | BLOOD | 0006-4971 | 1528-0020 | 138 | SCIE | HEMATOLOGY | 2021 | 25.669 | 1.9 | 0 | English | 2021 | 2021-11-23 | 10.1182/blood-2021-152008 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Article | Effects of initial texture on deformation behavior during cold rolling and static recrystallization during subsequent annealing of AZ31 alloy | This study demonstrates that the initial texture of Mg alloy significantly affects the microstructure developed during cold rolling and the recrystallization behavior during subsequent annealing. In a sample with a texture oriented toward the normal direction (ND sample), thick and large-sized shear bands are intensively formed during cold rolling and the deformation is strongly localized along these bands. In contrast, in a sample with a texture oriented toward the transverse direction (TD sample), many {10-12} twins are formed at the early stage of cold rolling, and then, numerous small-sized shear bands are formed in these twins. Results of nanoindentation tests reveal that the cold-rolled ND sample has internal strain energy that is substantially concentrated along the shear bands, whereas the cold-rolled TD sample has a large amount of internal strain energy that is homogeneously distributed throughout the material; this latter behavior is strongly related to the extensive {10-12} twinning and the resultant microstructural variations in the TD sample. During subsequent annealing, recrystallization occurs locally along the shear bands in the ND sample, which leads to the formation of a bimodal grain structure comprising fine recrystallized grains and coarse unrecrystallized grains. In contrast, during subsequent annealing of the TD sample, static recrystallization occurs homogeneously throughout the material, which results in the formation of a uniform grain structure that mostly comprises equiaxed recrystallized grains. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. | Lee, Sang Won; Han, Gukin; Jun, Tea-Sung; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Incheon Natl Univ, Dept Mech Engn, Incheon 22012, South Korea | ; Park, Sung-Hyuk/AAE-6726-2022; Lee, Sangwon/AAJ-7850-2020 | 57201375104; 57209738284; 56890702300; 54786002500 | sh.park@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 66 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 10.32 | 1.9 | 2.86 | 2025-07-30 | 46 | 44 | Magnesium alloy; Cold rolling; Initial texture; Twinning; Static recrystallization | MAGNESIUM ALLOYS; MG; MICROSTRUCTURE; DUCTILITY; EVOLUTION; SOLUTE | Cold rolling; Initial texture; Magnesium alloy; Static recrystallization; Twinning | Annealing; Cold rolling; Deformation; Grain size and shape; Magnesium alloys; Metal cladding; Shear bands; Strain energy; Textures; Bi-modal grain structure; Deformation behavior; Internal strains; Microstructural variation; Nanoindentation tests; Normal direction; Recrystallized grains; Static recrystallization; Recrystallization (metallurgy) | English | 2021 | 2021-03-10 | 10.1016/j.jmst.2020.04.074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Enhanced thermoelectric composite performance from mesoporous carbon additives in a commercial Bi0.5Sb1.5Te3 matrix | Composites were prepared, through hot pressing, using carbon materials with different pore size distributions as additives for commercial Bi0.5Sb1.5Te3 thermoelectric material (BST, p-type). Thermoelectric properties of the composites were measured in a temperature range of 298-473 K. Thermal conductivity of the composites, especially lattice thermal conductivity, was effectively decreased due to the mesoporous properties of the incorporated carbon additives. The electrical conductivity of the composites slightly decreased due to the electron scattering at the interface between the carbon material and the commercial BST matrix. The composite with 0.2 vol.% mesoporous carbon powder (36% mesoporosity) exhibited a figure of merit value approximately 10.7% higher than that of commercial BST without additives. This behavior resulted in 116% improved output power in the composite block-based single element compared with a bare BST thermoelectric block. The enhanced figure of merit was attributed to the effective reduction of lattice thermal conductivity by acoustic phonons scattering at the interface between the BST matrix and the mesoporous carbon as well as at the pore surfaces within the mesoporous carbon. By utilizing mesoporous carbon materials used in this study, the shortcomings and economic difficulties of the composite process with low dimensional carbon additives (carbon nanotubes, graphene, and nanodiamond) can be overcome for extensive practical applications. Mesoporous carbon powder with a tailored porosity distribution revealed the validity of bulk-type carbon additives to enhance the figure of merit of commercial thermoelectric materials. (C) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals. | Kim, Seong-Tae; Park, Jong Min; Park, Kwi-Il; Chun, Sang-Eun; Lee, Ho Seong; Choi, Pyuck-Pa; Yi, Seonghoon | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Mat Sci & Engn, 291 Daehak Ro, Daejeon 34141, South Korea | ; Yi, Seonghoon/HGC-6912-2022; Park, Kwiil/LKN-9445-2024 | 57224143373; 59074019700; 35280874200; 36801080300; 55706810400; 8085506500; 14008383000 | yish@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 1941-1162 | 94 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 10.32 | 1.9 | 1.36 | 2025-07-30 | 19 | 21 | Thermoelectric material; Bi0.5Sb1.5Te3; Mesoporous carbon; Lattice thermal conductivity; Figure of merit | BISMUTH TELLURIDE; THERMAL-CONDUCTIVITY; POWER GENERATION; NANOCOMPOSITES; ALLOYS; FIGURE; MERIT | Bi<sub>0.5</sub>Sb<sub>1.5</sub>Te<sub>3</sub>; Figure of merit; Lattice thermal conductivity; Mesoporous carbon; Thermoelectric material | Antimony compounds; Bismuth compounds; Crystal lattices; Electron scattering; Hot pressing; Mesoporous materials; Nanodiamonds; Pore size; Tellurium compounds; Thermal conductivity; Thermoelectric equipment; Thermoelectricity; Different pore sizes; Electrical conductivity; Lattice thermal conductivity; Mesoporous carbon materials; Porosity distributions; Thermo-Electric materials; Thermoelectric composite; Thermoelectric properties; Additives | English | 2021 | 2021-12-20 | 10.1016/j.jmst.2021.02.072 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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