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○ ○ Article ⓘ A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant disorder ⓘ Genes that are primarily expressed in cochlear glia-like supporting cells (GLSs) have not been clearly associated with progressive deafness. Herein, we present a deafness locus mapped to chromosome 3p25.1 and an auditory neuropathy spectrum disorder (ANSD) gene, TMEM43, mainly expressed in GLSs. We identify p.(Arg372Ter) of TMEM43 by linkage analysis and exome sequencing in two large Asian families segregating ANSD, which is characterized by inability to discriminate speech despite preserved sensitivity to sound. The knock-in mouse with the p.(Arg372Ter) variant recapitulates a progressive hearing loss with histological abnormalities in GLSs. Mechanistically, TMEM43 interacts with the Connexin26 and Connexin30 gap junction channels, disrupting the passive conductance current in GLSs in a dominant-negative fashion when the p.(Arg372Ter) variant is introduced. Based on these mechanistic insights, cochlear implant was performed on three subjects, and speech discrimination was successfully restored. Our study highlights a pathological role of cochlear GLSs by identifying a deafness gene and its causal relationship with ANSD. ⓘ Jang, Minwoo Wendy; Oh, Doo-Yi; Yi, Eunyoung; Liu, Xuezhong; Ling, Jie; Kim, Nayoung; Sharma, Kushal; Kim, Tai Young; Lee, Seungmin; Kim, Ah-Reum; Kim, Min Young; Kim, Min-A; Lee, Mingyu; Han, Jin-Hee; Han, Jae Joon; Park, Hye-Rim; Kim, Bong Jik; Lee, Sang-Yeon; Woo, Dong Ho; Oh, Jayoung; Oh, Soo-Jin; Du, Tingting; Koo, Ja-Won; Seung-Ha Oh; Shin, Hyun-Woo; Seong, Moon-Woo; Lee, Kyu-Yup; Kim, Un-Kyung; Shin, Jung Bum; Sang, Shushan; Cai, Xinzhang; Mei, Lingyun; He, Chufeng; Blanton, Susan H.; Chen, Zheng-Yi; Chen, Hongsheng; Liu, Xianlin; Nourbakhsh, Aida; Huang, Zaohua; Kang, Kwon-Woo; Park, Woong-Yang; Feng, Yong; Lee, C. Justin; Choi, Byung Yoon ⓘ Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea; Inst for Basic Sci Korea, Ctr Cognit & Social, Daejeon 34141, South Korea; Seoul Natl Univ, Dept Otorhinolaryngol, Bundang Hosp, Seongnam 13620, South Korea; Mokpo Natl Univ, Coll Pharm, Muan 58554, South Korea; Mokpo Natl Univ, Nat Med Res Inst, Muan 58554, South Korea; Univ Miami, Dept Otolaryngol, Miller Sch Med, Miami, FL 33136 USA; Univ Miami, Dept Otolaryngol, Dr John T Macdonald Fdn, Dept Human Genet,Hussman Inst Human Genom, Miami, FL 33136 USA; Cent South Univ, Xiangya Hosp, Dept Otolaryngol, Changsha 410008, Hunan, Peoples R China; Cent South Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha 410008, Hunan, Peoples R China; Samsung Med Ctr, Samsung Genome Inst, Seoul 06351, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Creat BioRes Grp, BK21 Plus Project, Sch Life Sci, Daegu 41566, South Korea; Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Dept Otorhinolaryngol, Seoul 03080, South Korea; Korea Inst Toxicol, Jeonbuk Dept Inhalat Res, Res Ctr Anim Model, Jeongeup 56212, South Korea; Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea; Univ Virginia, Dept Neurosci, Charlottesville, VA 22908 USA; Seoul Natl Univ Hosp, Dept Lab Med, Seoul 03080, South Korea; Kyungpook Natl Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Daegu 41944, South Korea; Harvard Med Sch, Dept Otol & Laryngol, Boston, MA 02114 USA; Eaton Peabody Lab, Boston, MA 02114 USA; Univ South China, Affiliated Changsha Cent Hosp, Dept Otolaryngol, Changsha 410004, Hunan, Peoples R China ⓘ ; Li, yulin/AGZ-5611-2022; Liu, Xianlin/LWI-4402-2024; Yi, Eunyoung/J-3173-2015; Kim, Yong-Tae/E-4148-2012; Lee, Doh Young/GLR-9586-2022; Du, Ting-Ting/KGL-0112-2024; Blanton, Susan/ABF-1323-2021; Kim, Jwa/AAH-9915-2021; Lee, C./AAC-1663-2019; ­, 한재준(의과대학 의학과)/AAT-6350-2020; KIM, JONG-IL/D-1019-2011; Ling, Jie/JJF-9995-2023; Woo, Dong Ho/ABY-9593-2022; CAI, XINZHANG/GQZ-3111-2022 ⓘ 57209227497; 56956292300; 14064203300; 26642875300; 57201300116; 59890743700; 57209161792; 56754397800; 57213176193; 55389709100; 57203466591; 56901535200; 56742453700; 57191830077; 58400089700; 57198436332; 36811908900; 56732157500; 7103062814; 57207250302; 56565876800; 57207573010; 19134860200; 56582818600; 55934512200; 12242712000; 22135779500; 7102248968; 7402724393; 55944745000; 22233352900; 14058487000; 14037285600; 7004956280; 57209865740; 36672677300; 57215138634; 57216441083; 37099770900; 57224187500; 7402229389; 55547104967; 7410148866; 57529370900 ⓘ fengyong_hn@hotmail.com;cjl@ibs.re.kr;choiby2010@gmail.com; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 1091-6490 118 22 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 1.24 2025-07-30 ⓘ 24 27 auditory neuropathy spectrum disorder; cochlea; glia-like supporting cells; connexins ⓘ AUDITORY NEUROPATHY; GAP-JUNCTIONS; HEARING IMPAIRMENT; SUPPORTING CELLS; HAIR-CELLS; MUTATIONS; DEAFNESS; DIFFERENTIATION; GUIDELINES; MECHANISM ⓘ Auditory neuropathy spectrum disorder; Cochlea; Connexins; Glia-like supporting cells ⓘ Animals; Cochlear Implantation; Codon, Nonsense; Connexins; Female; Genes, Dominant; Hearing Loss, Central; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Pedigree; Speech Perception; connexin 26; connexin 30; membrane protein; transmembrane protein 43; unclassified drug; gap junction protein; membrane protein; TMEM43 protein, human; adolescent; animal experiment; animal model; animal tissue; Article; auditory neuropathy spectrum disorder; autosomal dominant disorder; cell membrane; chromosome 3p; clinical article; controlled study; female; gene expression; gene locus; glia like supporting cell; hearing impairment; human; linkage analysis; mouse; nerve cell; nonhuman; nonsense mutation; protein localization; protein protein interaction; protein stability; speech discrimination; TMEM43 gene; vestibulocochlear nerve disease; whole exome sequencing; animal; C57BL mouse; cochlear implantation; dominant gene; genetics; hearing impairment; male; metabolism; pathophysiology; pedigree; speech perception; stop codon ⓘ English 2021 2021-06-01 10.1073/pnas.2019681118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Raf-like kinase is required for smoke-induced seed dormancy in Arabidopsis thaliana ⓘ Plants sense and integrate diverse stimuli to determine the timing for germination. A smoke compound, 3,4,5-trimethylfuran-2(5H)-one (trimethylbutenolide, TMB), has been identified to inhibit the seed germination of higher plants. To understand the mode of action, we examined various physiological and molecular aspects of the TMB-dependent inhibition of seed germination in Arabidopsis thaliana. The results indicated that the effect of TMB is due to the enhanced physiological dormancy, which is modulated by other dormancy regulatory cues such as after-ripening, stratification, and ABA/GA signaling. In addition, gene expression profiling showed that TMB caused genome-wide transcriptional changes, altering the expression of a series of dormancy-related genes. Based on the TMB-responsive physiological contexts in Arabidopsis, we performed mutant screening to isolate genetic components that underpin the TMB-induced seed dormancy. As a result, the TMB-RESISTANT1 (TES1) gene in Arabidopsis, encoding a B2 group Raf-like kinase, was identified. Phenotypic analysis of the tes1 mutant implicated that TES1 has a critical role in the TMB-responsive gene expression and the inhibition of seed germination. Taken together, we propose that plants have been equipped with a TMB sensory pathway through which the TMB induces the seed dormancy in a TES1-dependent way. ⓘ Lee, Inhye; Kim, Eunsun; Choi, Soobin; Kim, Dayoung; Hong, Wangyu; Choi, Jungki; Choi, Hyunmo; Kim, Jimin; Sable, Ganesh A.; Markkandan, Kesavan; Lim, Dongyeol; Park, Soon Ki; Kim, Soo Young; Lee, Sumin; Soh, Moon-Soo ⓘ Sejong Univ, Div Integrat Biosci & Biotechnol, Seoul 05006, South Korea; Sejong Univ, Dept Chem, Seoul 05006, South Korea; One Co Ltd, Bucheon Si 14585, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Chonnam Natl Univ, Dept Biotechnol, Gwangju 61186, South Korea; Chonnam Natl Univ, Kumho Life Sci Lab, Gwangju 61186, South Korea; Natl Inst Forest Sci, Forest Biomat Res Ctr, Jinju 52817, South Korea ⓘ ; Sable, Ganesh/GPC-4967-2022; Kim, Dahee/IAM-6955-2023; Sable, Ganesh A./GPC-4967-2022; Kim, Young/T-8521-2019 ⓘ 55653811300; 57206695906; 57207359969; 57203190431; 57222718696; 57203180714; 24474125300; 57222718876; 56768016700; 57190292801; 42262033800; 8055974900; 57218341521; 53981570100; 7004615614 ⓘ smlee55@sejong.ac.kr;soh@sejong.ac.kr; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 118 14 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 0.16 2025-07-30 ⓘ 6 7 smoke compound; seed dormancy; germination; Raf-like kinase; Arabidopsis ⓘ ⓘ Arabidopsis; Germination; Raf-like kinase; Seed dormancy; Smoke compound ⓘ Arabidopsis; Drug Resistance; Furans; Germination; Plant Dormancy; Seeds; Smoke; 3,4,5 trimethylfuran 2(5h) one; Raf protein; toxic substance; unclassified drug; 3,4,5-trimethylfuran-2(5H)-one; furan derivative; ABA gene; Arabidopsis thaliana; Article; controlled study; GA gene; gene expression profiling; gene isolation; genetic analysis; genetic transcription; germination; nonhuman; pilot study; plant development; plant gene; priority journal; seed dormancy; signal transduction; smoke; TMB RESISTANT1 gene; Arabidopsis; dormancy; drug effect; drug resistance; metabolism; plant seed; smoke ⓘ English 2021 2021-04-06 10.1073/pnas.2020636118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Orbit topology analyzed from π phase shift of magnetic quantum oscillations in three-dimensional Dirac semimetal ⓘ With the emergence of Dirac fermion physics in the field of condensed matter, magnetic quantum oscillations (MQOs) have been used to discern the topology of orbits in Dirac materials. However, many previous researchers have relied on the single-orbit Lifshitz- Kosevich (LK) formula, which overlooks the significant effect of degenerate orbits on MQOs. Since the single-orbit LK formula is valid for massless Dirac semimetals with small cyclotron masses, it is imperative to generalize the method applicable to a wide range of Dirac semimetals, whether massless or massive. This report demonstrates how spin-degenerate orbits affect the phases in MQOs of three-dimensional massive Dirac semimetal, NbSb2. With varying the direction of the magnetic field, an abrupt pi phase shift is observed due to the interference between the spin-degenerate orbits. We investigate the effect of cyclotron mass on the pi phase shift and verify its close relation to the phase from the Zeeman coupling. We find that the pi phase shift occurs when the cyclotron mass is half of the electron mass, indicating the effective spin gyromagnetic ratio as gs = 2. Our approach is not only useful for analyzing MQOs of massless Dirac semimetals with a small cyclotron mass but also can be used for MQOs in massive Dirac materials with degenerate orbits, especially in topological materials with a sufficiently large cyclotron mass. Furthermore, this method provides a useful way to estimate the precise gs value of the material. ⓘ Lee, Sang-Eon; Oh, Myeong-Jun; Ji, Sanghyun; Kim, Jinsu; Jun, Jin-Hyeon; Kang, Woun; Jo, Younjung; Jung, Myung-Hwa ⓘ Sogang Univ, Dept Phys, Seoul 04107, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Ewha Womans Univ, Dept Phys, Seoul 03760, South Korea ⓘ Jo, Myunglae/AAE-4499-2022; kim, jinsu/JEP-4929-2023 ⓘ 57223100388; 57193517449; 57216373546; 57191683580; 57216871100; 7202402145; 13502586500; 8695574600 ⓘ jophy@knu.ac.kr;mhjung@sogang.ac.kr; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 118 29 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 0.22 2025-07-30 ⓘ 6 4 topological semimetal  magnetic quantum oscillation  orbit topology  spin-degenerate system ⓘ MAGNETORESISTANCE; INSULATOR; ELECTRONS; SURFACE; BI2SE3 ⓘ Topological semimetal | magnetic quantum oscillation | orbit topology | spin-degenerate system ⓘ metal; Article; channel gating; crystal structure; density functional theory; electron spin resonance; Fourier analysis; impedance; magnetic field; mathematical analysis; orbit; oscillation; physical phase; quantum mechanics; time series analysis; X ray diffraction ⓘ English 2021 2021-07-20 10.1073/pnas.2023027118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury ⓘ Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in phosphate and vitamin D homeostasis. In acute kidney injury (AKI) patients, high-circulating FGF23 levels are associated with disease progression and mortality. However, the organ and cell type of FGF23 production in AKI and the molecular mechanism of its excessive production are still unidentified. For insight, we investigated folic acid (FA)-induced AKI in mice. Interestingly, simultaneous with FGF23, orphan nuclear receptor ERR-gamma expression is increased in the liver of FA-treated mice, and ectopic overexpression of ERR-gamma was sufficient to induce hepatic FGF23 production. In patients and in mice, AKI is accompanied by up-regulated systemic IL-6, which was previously identified as an upstream regulator of ERR-gamma expression in the liver. Administration of IL-6 neutralizing antibody to FAtreated mice or of recombinant IL-6 to healthy mice confirms IL-6 as an upstream regulator of hepatic ERR-gamma-mediated FGF23 production. A significant (P < 0.001) interconnection between high IL-6 and FGF23 levels as a predictor of AKI in patients that underwent cardiac surgery was also found, suggesting the clinical relevance of the finding. Finally, liver-specific depletion of ERR-gamma or treatment with an inverse ERR-gamma agonist decreased hepatic FGF23 expression and plasma FGF23 levels in mice with FA-induced AKI. Thus, inverse agonist of ERR-gamma may represent a therapeutic strategy to reduce adverse plasma FGF23 levels in AKI. ⓘ Radhakrishnan, Kamalakannan; Kim, Yong-Hoon; Jung, Yoon Seok; Kim, Don-Kyu; Na, Soon-Young; Lim, Daejin; Kim, Dong Hun; Kim, Jina; Kim, Hyung-Seok; Choy, Hyon E.; Cho, Sung Jin; Lee, In-Kyu; Ayvaz, Samil; Nittka, Stefanie; Fliser, Danilo; Schunk, Stefan J.; Speer, Thimoteus; Dooley, Steven; Lee, Chul-Ho; Choi, Hueng-Sik ⓘ Chonnam Natl Univ, Sch Biol Sci & Technol, Gwangju 61186, South Korea; Korea Res Inst Biosci & Biotechnol, Lab Anim Resource Ctr, Daejeon 34141, South Korea; Univ Sci & Technol, Dept Funct Genom, Sch Biosci, Korea Res Inst Biosci & Biotechnol, Daejeon 34141, South Korea; Chonnam Natl Univ, Dept Mol Biotechnol, Gwangju 61186, South Korea; Chonnam Natl Univ, Med Sch, Dept Microbiol, Gwangju 61468, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41404, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Chonnam Natl Univ, Dept Forens Med, Med Sch, Gwangju 61468, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Heidelberg Univ, Med Fac Mannheim, Dept Med 2, D-68167 Mannheim, Germany; Heidelberg Univ, Med Fac Mannheim, Inst Clin Chem, D-68167 Mannheim, Germany; Saarland Univ, Dept Internal Med Nephrol & Hypertens 4, D-66421 Homburg, Germany ⓘ ; Lee, Chul-Ho/MBV-8603-2025; Jung, Yoon/B-8512-2011; Dooley, Steven/T-6491-2018; Lee, In-Kyu/AAR-6374-2021; Radhakrishnan, Kamalakannan/HNP-0477-2023 ⓘ 57217673988; 57210989406; 57203348590; 37081358700; 7102024265; 55634007200; 57223020477; 56949261900; 57218341796; 7006232598; 58735369700; 59060573600; 57222998291; 57210776023; 7005165997; 57204505793; 36097022700; 35402441200; 56223516500; 7404338771 ⓘ steven.dooley@medma.uni-heidelberg.de;chullee@kribb.re.kr;hsc@chonnam.ac.kr;steven.dooley@medma.uniheidelberg.de; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 118 16 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 1.3 2025-07-30 ⓘ 26 25 acute kidney injury; ERR-gamma; FGF23; interleukin 6; orphan nuclear receptor ⓘ GROWTH-FACTOR 23; VITAMIN-D; INVERSE AGONIST; EXPRESSION; PHOSPHATE; PHOSPHORYLATION; INFLAMMATION; INHIBITION; FGF-23; ORGAN ⓘ Acute kidney injury; ERR-γ; FGF23; Interleukin 6; Orphan nuclear receptor ⓘ Acute Kidney Injury; Animals; Disease Models, Animal; Fibroblast Growth Factor-23; Folic Acid; Interleukin-6; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Receptors, Estrogen; Transcriptional Activation; fibroblast growth factor 23; folic acid; interleukin 6; neutralizing antibody; orphan nuclear receptor; protein estrogen related receptor gamma; unclassified drug; Esrrg protein, mouse; estrogen receptor; Fgf23 protein, mouse; folic acid; interleukin 6; orphan nuclear receptor; acute kidney failure; animal cell; animal experiment; animal tissue; Article; clinical feature; cohort analysis; controlled study; DNA synthesis; gene expression; gene overexpression; gluconeogenesis; heart surgery; human; immunohistochemistry; in vivo study; male; molecular cloning; mouse; nonhuman; prediction; priority journal; protein blood level; protein depletion; protein expression; protein function; protein secretion; real time polymerase chain reaction; RNA extraction; upregulation; Western blotting; acute kidney failure; animal; C57BL mouse; disease model; genetics; kidney; liver; metabolism; pathophysiology; transcription initiation ⓘ English 2021 2021-04-20 10.1073/pnas.2022841118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Quadruple ultrasound, photoacoustic, optical coherence, and fluorescence fusion imaging with a transparent ultrasound transducer ⓘ Ultrasound and optical imagers are used widely in a variety of biological and medical applications. In particular, multimodal implementations combining light and sound have been actively investigated to improve imaging quality. However, the integration of optical sensors with opaque ultrasound transducers suffers from low signal-to-noise ratios, high complexity, and bulky form factors, significantly limiting its applications. Here, we demonstrate a quadruple fusion imaging system using a spherically focused transparent ultrasound transducer that enables seamless integration of ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging. As a first application, we comprehensively monitored multiparametric responses to chemical and suture injuries in rats' eyes in vivo, such as corneal neovascularization, structural changes, cataracts, and inflammation. As a second application, we successfully performed multimodal imaging of tumors in vivo, visualizing melanomas without using labels and visualizing 4T1 mammary carcinomas using PEGylated gold nanorods. We strongly believe that the seamlessly integrated multimodal system can be used not only in ophthalmology and oncology but also in other healthcare applications with broad impact and interest. ⓘ Park, Jeongwoo; Park, Byullee; Kim, Tae Yeong; Jung, Sungjin; Choi, Woo June; Ahn, Joongho; Yoon, Dong Hee; Kim, Jeongho; Jeon, Seungwan; Lee, Donghyun; Yong, Uijung; Jang, Jinah; Kim, Won Jong; Kim, Hong Kyun; Jeong, Unyong; Kim, Hyung Ham; Kim, Chulhong ⓘ Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Med Device Innovat Ctr, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Dept Creat IT Engn, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang 37673, South Korea; Chung Ang Univ, Sch Elect & Elect Engn, Seoul 06974, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Dept Chem, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Dept Elect Engn, Pohang 37673, South Korea ⓘ ; Park, Byullee/ITU-4262-2023; Park, Jeongwoo/LIC-1971-2024; Kim, Chang-Hoon/D-7205-2016; Yong, Uijung/NPJ-0657-2025; Jang, Jinah/AGE-7920-2022 ⓘ 57205588351; 57200376082; 57204738205; 57211573322; 24070138500; 57194204029; 57201671265; 57219385573; 57188856394; 59695409100; 57216159817; 55212064400; 7405810991; 57218260940; 6603678987; 14829036600; 57202234822 ⓘ okeye@knu.ac.kr;ujeong@postech.ac.kr;david.kim@postech.ac.kr;chulhong@postech.edu; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 1091-6490 118 11 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 8.05 2025-07-30 ⓘ 140 174 transparent ultrasound transducer; optical imaging; ultrasound imaging; multimodal imaging ⓘ HIGH-RESOLUTION; TOMOGRAPHY; MICROSCOPY; ANGIOGRAPHY; SYSTEM; TRENDS ⓘ Multimodal imaging; Optical imaging; Transparent ultrasound transducer; Ultrasound imaging ⓘ gold nanorod; metal oxide; platelet endothelial cell adhesion molecule 1; silver nanoparticle; animal experiment; animal model; anterior eye segment; Article; B scan; breast carcinoma; cataract; central corneal thickness; contrast enhancement; controlled study; cornea edema; cornea neovascularization; drug accumulation; echography; excitation contraction coupling; eye inflammation; eye injury; eye melanoma; eye surgery; eye tumor; fluorescence imaging; frequency modulation; image analysis; image processing; impedance; in vivo study; molecular imaging; mouse; nonhuman; optical coherence tomography; photoacoustics; piezoelectricity; quadruple echography; rat; sensitivity and specificity; signal noise ratio; suture technique; three-dimensional imaging ⓘ English 2021 2021-03-16 10.1073/pnas.1920879118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin-2 and pyruvate dehydrogenase kinase-2 axis in the dorsal root ganglion ⓘ Diabetic peripheral neuropathy (DPN) is a common complication of uncontrolled diabetes. The pathogenesis of DPN is associated with chronic inflammation in dorsal root ganglion (DRG), eventually causing structural and functional changes. Studies on DPN have primarily focused on neuronal component, and there is limited knowledge about the role of satellite glial cells (SGCs), although they completely enclose neuronal soma in DRG. Lipocalin-2 (LCN2) is a pro-inflammatory acute-phase protein found in high levels in diverse neuroinflammatory and metabolic disorders. In diabetic DRG, the expression of LCN2 was increased exclusively in the SGCs. This upregulation of LCN2 in SGCs correlated with increased inflammatory responses in DRG and sciatic nerve. Furthermore, diabetes-induced inflammation and morphological changes in DRG, as well as sciatic nerve, were attenuated in Lcn2 knockout (KO) mice. Lcn2 gene ablation also ameliorated neuropathy phenotype as determined by nerve conduction velocity and intraepidermal nerve fiber density. Mechanistically, studies using specific gene KO mice, adenovirus-mediated gene overexpression strategy, and primary cultures of DRG SGCs and neurons have demonstrated that LCN2 enhances the expression of mitochondrial gate-keeping regulator pyruvate dehydrogenase kinase-2 (PDK2) through PPAR beta/delta, thereby inhibiting pyruvate dehydrogenase activity and increasing production of glycolytic end product lactic acid in DRG SGCs and neurons of diabetic mice. Collectively, our findings reveal a crucial role of glial LCN2-PPAR beta/delta-PDK2-lactic acid axis in progression of DPN. Our results establish a link between pro-inflammatory LCN2 and glycolytic PDK2 in DRG SGCs and neurons and propose a novel glia-based mechanism and drug target for therapy of DPN. Main Points Diabetes upregulates LCN2 in satellite glia, which in turn increases pyruvate dehydrogenase kinase-2 (PDK2) expression and lactic acid production in dorsal root ganglia (DRG). Glial LCN2-PDK2-lactic acid axis in DRG plays a crucial role in the pathogenesis of diabetic neuropathy. ⓘ Bhusal, Anup; Rahman, Md Habibur; Lee, Won-Ha; Lee, In-Kyu; Suk, Kyoungho ⓘ Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Creat BioRes Grp, Brain Korea 21 Plus, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea ⓘ Lee, In-Kyu/AAR-6374-2021; Rahman, Md Habibur/HMD-4572-2023 ⓘ 57200274141; 59607139800; 57205609794; 36071537600; 7005114595 ⓘ ksuk@knu.ac.kr; ⓘ GLIA ⓘ GLIA ⓘ 0894-1491 1098-1136 69 4 SCIE NEUROSCIENCES ⓘ 2021 8.073 11.5 1.77 2025-07-30 ⓘ 26 25 diabetes; dorsal root ganglion; lipocalin&#8208; 2; neuropathy; pyruvate dehydrogenase kinase; satellite glial cells ⓘ NECROSIS-FACTOR-ALPHA; SENSING ION CHANNELS; ASTROCYTE-DERIVED LIPOCALIN-2; NERVE-FIBER QUANTIFICATION; GENE-EXPRESSION; TNF-ALPHA; SENSORY NEUROPATHY; INSULIN-RESISTANCE; TRIGEMINAL GANGLIA; CELL-PROLIFERATION ⓘ diabetes; dorsal root ganglion; lipocalin-2; neuropathy; pyruvate dehydrogenase kinase; satellite glial cells ⓘ Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Inflammation; Lactic Acid; Lipocalin-2; Mice; Mice, Knockout; NAD; Neuroglia; PPAR-beta; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; glucose; insulin glargine; lactic acid; messenger RNA; myelin; neutrophil gelatinase associated lipocalin; peroxisome proliferator activated receptor delta; protein S 100; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 2; tumor necrosis factor; lactic acid; neutrophil gelatinase associated lipocalin; nicotinamide adenine dinucleotide; peroxisome proliferator activated receptor delta; acidification; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; diabetic neuropathy; diabetogenesis; enzyme activity; fluorescence intensity; gene overexpression; glucose blood level; hyperglycemia; immunohistochemistry; immunoreactivity; inflammation; male; mouse; MTT assay; myelination; nerve conduction velocity; nerve fiber; nervous system inflammation; nonhuman; pH; primary culture; priority journal; protein expression; satellite glial cell; Schwann cell; sciatic nerve; spinal ganglion; upregulation; von Frey test; Western blotting; animal; experimental diabetes mellitus; genetics; glia; knockout mouse; spinal ganglion ⓘ English 2021 2021-04 10.1002/glia.23942 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages ⓘ Expression and function of odorant receptors (ORs), which account for more than 50% of G protein-coupled receptors, are being increasingly reported in nonolfactory sites. However, ORs that can be targeted by drugs to treat diseases remain poorly identified. Tumorderived lactate plays a crucial role in multiple signaling pathways leading to generation of tumor-associated macrophages (TAMs). In this study, we hypothesized that the macrophage OR Olfr78 functions as a lactate sensor and shapes the macrophage-tumor axis. Using Olfr78+/+ and Olfr78-/- bone marrow-derived macrophages with or without exogenous Olfr78 expression, we demonstrated that Olfr78 sensed tumor-derived lactate, whichwas themain factor in tumor-conditioned media responsible for generation of protumoral M2-TAMs. Olfr78 functioned together with Gpr132 to mediate lactate-induced generation of protumoral M2-TAMs. In addition, syngeneic Olfr78-deficient mice exhibited reduced tumor progression and metastasis together with an increased anti- versus protumoral immune cell population. We propose that the Olfr78-lactate interaction is a therapeutic target to reduce and prevent tumor progression and metastasis. © 2021 National Academy of Sciences. All rights reserved. ⓘ Vadevoo, Sri Murugan Poongkavithai; Gunassekaran, Gowri Rangaswamy; Lee, ChaeEun; Lee, NaHye; Lee, Jiyoun; Chae, Sehyun; Park, Jae-Yong; Koo, JaeHyung; Lee, Byungheon ⓘ Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University (KNU), Daegu, 41944, South Korea, BK21 FOUR KNU Convergence Education Program, Department of Biomedical Science, School of Medicine, KNU, Daegu, 41944, South Korea, CMRI, School of Medicine, KNU, Daegu, 41944, South Korea; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University (KNU), Daegu, 41944, South Korea, BK21 FOUR KNU Convergence Education Program, Department of Biomedical Science, School of Medicine, KNU, Daegu, 41944, South Korea, CMRI, School of Medicine, KNU, Daegu, 41944, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea, New Biology Research Center, DGIST, Daegu, 42988, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea, New Biology Research Center, DGIST, Daegu, 42988, South Korea; BK21 FOUR R&E Center for Learning Health Systems, School of Biosystem and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, South Korea; Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, 41062, South Korea; BK21 FOUR R&E Center for Learning Health Systems, School of Biosystem and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, 02841, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea, New Biology Research Center, DGIST, Daegu, 42988, South Korea; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University (KNU), Daegu, 41944, South Korea, BK21 FOUR KNU Convergence Education Program, Department of Biomedical Science, School of Medicine, KNU, Daegu, 41944, South Korea, CMRI, School of Medicine, KNU, Daegu, 41944, South Korea ⓘ ⓘ 56663280000; 36028043400; 57205608214; 56437850400; 57255852300; 55305469400; 57206479071; 8610443800; 16304374900 ⓘ leebh@knu.ac.kr;jkoo001@dgist.ac.kr; ⓘ Proceedings of the National Academy of Sciences of the United States of America ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 1091-6490 118 37 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 3.78 2025-07-30 ⓘ 88 ⓘ ⓘ GPCR; Lactate; Olfr78; OR51E2; TAMs ⓘ Animals; Cell Cycle Proteins; Cell Line, Tumor; Female; Humans; Lactic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Phenotype; Receptors, G-Protein-Coupled; Receptors, Odorant; Signal Transduction; Tumor Microenvironment; Tumor-Associated Macrophages; acetic acid; arginase; beta 2 adrenergic receptor; CD11b antigen; CD163 antigen; CD86 antigen; chaperone; G protein coupled receptor; G protein coupled receptor 132; gamma interferon; glucocorticoid receptor; interleukin 10; interleukin 12; interleukin 12p40; interleukin 4; lactate dehydrogenase; lactic acid; lipopolysaccharide; luciferase; mannose receptor; nitric oxide synthase; oxamic acid; phorbol 13 acetate 12 myristate; receptor type tyrosine protein phosphatase C; small interfering RNA; transforming growth factor beta; unclassified drug; cell cycle protein; G protein coupled receptor; G2A receptor; lactic acid; Olfr78 protein, mouse; 4T1 cell line; A-549 cell line; animal cell; animal experiment; animal model; antineoplastic activity; Article; B16-F10 cell line; bioluminescence resonance energy transfer; bone marrow derived macrophage; cancer transplantation; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; cell proliferation; chemoreceptor; coimmunoprecipitation; confocal microscopy; controlled study; EC50; enzyme linked immunosorbent assay; female; flow cytometry; fluorescence activated cell sorting; gene expression; glioblastoma; human; human cell; immunofluorescence; immunohistochemistry; invasive breast cancer; Lewis lung carcinoma cell line; luciferase assay; lung adenocarcinoma; M1 macrophage; M2 macrophage; M2 tumor-associated macrophage; male; MCF-7 cell line; MDA-MB-231 cell line; mouse; myeloid-derived suppressor cell; nonhuman; nucleotide sequence; olfactory receptor; olfactory receptor 78; olfactory receptor family 51 subfamily E member 2; protein expression; protein isolation; real time polymerase chain reaction; regulatory T lymphocyte; THP-1 cell line; tumor growth; Western blotting; animal; C57BL mouse; macrophage; metabolism; olfactory receptor; phenotype; physiology; signal transduction; tumor cell line; tumor microenvironment ⓘ English Final 2021 10.1073/pnas.2102434118 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Unexpected nascent atmospheric emissions of three ozone-depleting hydrochlorofluorocarbons ⓘ Global and regional atmospheric measurements and modeling can play key roles in discovering and quantifying unexpected nascent emissions of environmentally important substances. We focus here on three hydrochlorofluorocarbons (HCFCs) that are restricted by the Montreal Protocol because of their roles in stratospheric ozone depletion. Based on measurements of archived air samples and on in situ measurements at stations of the Advanced Global Atmospheric Gases Experiment (AGAGE) network, we report global abundances, trends, and regional enhancements for HCFC-132b (CH2ClCCIF2), which is newly discovered in the atmosphere, and updated results for HCFC-133a (CH2ClCF3) and HCFC-31 (CH2ClF). No purposeful end-use is known for any of these compounds. We find that HCFC-132b appeared in the atmosphere 20 y ago and that its global emissions increased to 1.1 Gg.y(-1) by 2019. Regional top-down emission estimates for East Asia, based on high-frequency measurements for 2016-2019, account for similar to 95% of the global HCFC-132b emissions and for similar to 80% of the global HCFC-133a emissions of 2.3 Gg.y(-1) during this period. Global emissions of HCFC-31 for the same period are 0.71 Gg.y(-1). Small European emissions of HCFC-132b and HCFC-133a, found in southeastern France, ceased in early 2017 when a fluorocarbon production facility in that area closed. Although unreported emissive end-uses cannot be ruled out, all three compounds are most likely emitted as intermediate by-products in chemical production pathways. Identification of harmful emissions to the atmosphere at an early stage can guide the effective development of global and regional environmental policy. ⓘ Vollmer, Martin K.; Muhle, Jens; Henne, Stephan; Young, Dickon; Rigby, Matthew; Mitrevski, Blagoj; Park, Sunyoung; Lunder, Chris R.; Rhee, Tae Siek; Harth, Christina M.; Hill, Matthias; Langenfelds, Ray L.; Guillevic, Myriam; Schlauri, Paul M.; Hermansen, Ove; Arduini, Jgor; Wang, Ray H. J.; Salameh, Peter K.; Maione, Michela; Krummel, Paul B.; Reimann, Stefan; O'Doherty, Simon; Simmonds, Peter G.; Fraser, Paul J.; Prinn, Ronald G.; Weiss, Ray F.; Steele, L. Paul ⓘ Empa, Swiss Fed Labs Mat Sci & Technol, Lab Air Pollut & Environm Technol, CH-8600 Dubendorf, Switzerland; Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA; Univ Bristol, Sch Chem, Atmospher Chem Res Grp, Bristol BS8 1TL, Avon, England; CSIRO, Climate Sci Ctr, CSIRO Oceans & Atmosphere, Aspendale, Vic 3195, Australia; Kyungpook Natl Univ, Dept Oceanog, Daegu 41566, South Korea; Norwegian Inst Air Res, Monitoring & Instrumentat Technol Dept, N-2007 Kjeller, Norway; Korea Polar Res Inst, Div Ocean Sci, Incheon 21990, South Korea; Univ Urbino, Dept Pure & Appl Sci, I-61029 Urbino, Italy; Italian Natl Res Council, Inst Atmospher Sci & Climate, I-40129 Bologna, Italy; Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA; MIT, Ctr Global Change Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA ⓘ Mitrevski, Blagoj/JAT-7514-2023; Muhle, Jens/GPX-3244-2022; arduini, jgor/N-2798-2016; Steele, Paul/B-3185-2009; Langenfelds, Raymond/B-5381-2012; Reimann, Stefan/A-2327-2009; Young, Dickon/AFO-7065-2022; Henne, Stephan/A-3467-2009; Langenfelds, Ray/B-5381-2012; Fraser, Paul/D-1755-2012; Rigby, Matthew/A-5555-2012; Krummel, Paul/A-4293-2013 ⓘ 56668474200; 55917306500; 6602332157; 22837436400; 38762109000; 8640621400; 57085459500; 15835085000; 14060858300; 8878471400; 35579918200; 6602828441; 57198499831; 57215866560; 23485571500; 7801467546; 35345968200; 6602378882; 7005182425; 6602579613; 7006466341; 6603729725; 7102204006; 7202782061; 7005942405; 7404027402; 7102165442 ⓘ Martin.Vollmer@empa.ch; ⓘ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ⓘ P NATL ACAD SCI USA ⓘ 0027-8424 118 5 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 12.779 11.5 0.81 2025-07-30 ⓘ 19 17 Montreal Protocol; atmospheric composition; ozone depletion ⓘ GLOBAL EMISSIONS; 1ST OBSERVATIONS; INCREASE; TRENDS; HALOCARBONS; HISTORIES; CCL2F2; GASES; CCL3F ⓘ Atmospheric composition; Montreal Protocol; Ozone depletion ⓘ 1,2 dichloro 1,1 difluoroethane; 2 chloro 1,1,1 trifluoroethane; chlorofluorohydrocarbon; chlorofluoromethane; unclassified drug; air sampling; Article; Asia; carbon footprint; controlled study; environmental policy; France; geographic distribution; industrialization; measurement; ozone depletion; priority journal; stratosphere ⓘ English 2021 2021-02-02 10.1073/pnas.2010914118 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Adaptive single input sliding mode control for hybrid-synchronization of uncertain hyperchaotic Lu systems ⓘ This paper addresses the problem of hybrid synchronization for hyperchaotic Lu systems without and with uncertain parameters via a single input sliding mode controller (SMC). Based on the SMC approach, the proposed controller not only minimizes the influence of uncertainty but also enhances the robustness of the system. The uncertain parameters are estimated by using new adaptation laws which ensure the uncertain parameters convergence to their original value. A hybrid synchronization scheme is useful to maintain the vastly secured and secrecy in the area of secure communication by using the control theory approach. The proposed hybrid synchronization results are providing a superiority of forming a chaotic secure communication scheme. Finally, a numerical example is provided to demonstrate the validity of the theoretical analysis. (c) 2021 The Franklin Institute. Published by Elsevier Ltd. All rights reserved. ⓘ Singh, Satnesh; Han, Seungyong; Lee, S. M. ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, Cyber Phys Syst & Control Lab, Daehak Ro 80, Daegu, South Korea ⓘ ; Singh, Satnesh/AAE-2301-2020; Lee, Sangmoon/C-4502-2018 ⓘ 57217110503; 57200991395; 59510733500 ⓘ moony@knu.ac.kr; ⓘ JOURNAL OF THE FRANKLIN INSTITUTE ⓘ J FRANKLIN I ⓘ 0016-0032 1879-2693 358 15 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS ⓘ 2021 4.246 11.6 0.62 2025-07-30 ⓘ 7 10 ⓘ SECURE CHAOTIC COMMUNICATION; ANTI-SYNCHRONIZATION; FEEDBACK ⓘ ⓘ Adaptive control systems; Controllers; Numerical methods; Secure communication; Synchronization; Uncertainty analysis; Adaptation law; Hybrid synchronizations; Hyperchaotic; Lu's systems; Parameter convergence; Single input; Sliding mode controller; Sliding-mode control; Uncertain parameters; Uncertainty; Sliding mode control ⓘ English 2021 2021-10 10.1016/j.jfranklin.2021.07.037 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Affine matched parameterization approach to sampled-data stabilization criteria for T-S fuzzy systems with variable sampling ⓘ This paper presents new parameterized sampled-data stabilization criteria using affine transformed membership functions for T-S fuzzy systems. To deal with the sampled control input having aperiodic sampling intervals, the proposed method adopts new looped functionals, and employs a modified free weighting matrix inequality. A relaxed condition for the controller design is derived by formulating the constraint conditions of the membership functions in the proposed controller with affinely matched weighting parameter vectors. Based on a newly devised lemma for handling affinely matched vectors, the stabilization and guaranteed cost performance criteria are given in terms of linear matrix inequalities (LMIs). The superiority of the presented method is demonstrated via significantly improved results in numerical examples. (C) 2021 The Franklin Institute. Published by Elsevier Ltd. All rights reserved. ⓘ Jin, Yongsik; Kwon, W.; Lee, S. M. ⓘ Elect & Telecommun Res Inst ETRI, Med IT Convergence Res Sect, Daegu 42994, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daehak Ro 80, Daegu, South Korea; Elect & Telecommun Res Inst ETRI, Smart Mobil Res Sect, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Cyber Phys Syst & Control Lab, Daehak Ro 80, Daegu, South Korea ⓘ Lee, Seunghoon/AAR-6570-2020; Jin, Yongsik/AAH-6959-2021; Lee, Sangmoon/C-4502-2018 ⓘ 57020309300; 57212541649; 59510733500 ⓘ moony@knu.ac.kr; ⓘ JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS ⓘ J FRANKLIN I ⓘ 0016-0032 1879-2693 358 7 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS ⓘ 2021 4.246 11.6 0.93 2025-07-30 ⓘ 13 14 ⓘ H-INFINITY CONTROL; STABILITY ANALYSIS; RELAXED STABILITY; UNCERTAIN GRADES; CHAOTIC SYSTEMS; MODEL; DESIGN; SUBJECT; MATRIX ⓘ ⓘ Fuzzy systems; Linear matrix inequalities; Numerical methods; Parameterization; Robustness (control systems); Stabilization; Control inputs; Free-weighting matrices; Looped-functionals; Memberships function; Parameterized; Sampled data stabilization; Sampling interval; Stabilization criteria; T S fuzzy system; Variable sampling; Membership functions ⓘ English 2021 2021-05 10.1016/j.jfranklin.2021.02.023 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Cilostazol versus aspirin in ischemic stroke with cerebral microbleeds versus prior intracerebral hemorrhage ⓘ Background: In PreventIon of CArdiovascular Events in Ischaemic Stroke Patients with High Risk of Cerebral HaemOrrhage (PICASSO), cilostazol versus aspirin was comparable for the end points of cerebral hemorrhage and major vascular events. However, underlying hemorrhage-prone lesions could modify the treatment effect. Aims: We explored whether the safety and efficacy of cilostazol versus aspirin would differ between hemorrhage-prone lesions (multiple cerebral microbleeds vs. prior intracerebral hemorrhage). Methods: In this post hoc analysis of PICASSO, we divided patients into the cerebral microbleeds and prior intracerebral hemorrhage subgroups. The primary safety end point was the first occurrence of cerebral hemorrhage. The primary efficacy end point was the composite of stroke, myocardial infarction, or vascular death. Results: Of 1512 patients, 903 (59.7%) had multiple cerebral microbleeds and 609 (40.3%) had prior intracerebral hemorrhage. The cerebral hemorrhage risk was lower with cilostazol versus aspirin (0.12%/year vs. 1.49%/year; hazard ratio, 0.08 [95% confidence interval 0.01-0.60];p = 0.015) in the cerebral microbleeds subgroup, but was not different (1.26%/year vs. 0.79%/year; hazards ratio 1.60 [0.52-4.90];p = 0.408) in the prior intracerebral hemorrhage subgroup. The interaction of treatment-by-subgroup was significant (p(interaction) = 0.011). For the composite of major vascular events, there was a trend toward a lower risk with cilostazol versus aspirin (3.56%/year vs. 5.53%/year; hazards ratio 0.64 [0.41-1.01];p = 0.056) in the cerebral microbleeds subgroup, but was comparable (5.21%/year vs. 5.05%/year; hazards ratio 1.03 [0.63-1.67];p = 0.913) in the prior intracerebral hemorrhage subgroup without a significant treatment-by-subgroup interaction (p(interaction) = 0.165). Conclusions: Cilostazol versus aspirin might be a better option in ischemic stroke with multiple cerebral microbleeds, ut confirmatory trials are needed. ⓘ Park, Hong-Kyun; Lee, Ji Sung; Kim, Bum Joon; Park, Jong-Ho; Kim, Yong-Jae; Yu, Sungwook; Hwang, Yang-Ha; Rha, Joung-Ho; Heo, Sung Hyuk; Ahn, Seong Hwan; Seo, Woo-Keun; Park, Jong-Moo; Lee, Ju-Hun; Kwon, Jee-Hyun; Sohn, Sung-Il; Jung, Jin-Man; Kwon, Sun U.; Hong, Keun-Sik ⓘ Inje Univ, Dept Neurol, Ilsan Paik Hosp, Goyang, South Korea; Univ Ulsan, Clin Res Ctr, Asan Med Ctr, Asan Inst Life Sci,Coll Med, Seoul, South Korea; Kyung Hee Univ, Dept Neurol, Med Ctr, Seoul, South Korea; Hanyang Univ, Myungji Hosp, Dept Neurol, Coll Med, Goyang, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Dept Neurol, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Inha Univ Hosp, Dept Neurol, Incheon, South Korea; Chosun Univ, Dept Neurol, Sch Med & Hosp, Gwangju, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Neurol, Seoul, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Neurol, Seoul, South Korea; Ulsan Univ, Ulsan Univ Hosp, Dept Neurol, Ulsan, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Daegu, South Korea; Korea Univ, Ansan Hosp, Dept Neurol, Seoul, South Korea; Ulsan Univ, Asan Med Ctr, Dept Neurol, Seoul, South Korea ⓘ Kim, Dong/AAH-2257-2021; Jung, Jin-Man/LJL-8037-2024; Kim, Yong-Jae/JQW-5758-2023; HWANG, Yang-Ha/F-3068-2013; Heo, Sung/P-3529-2019 ⓘ 58205849100; 57212925539; 57214661365; 55716977200; 55865497600; 56144716300; 7402311308; 6701393879; 18835720200; 57200401172; 22981667600; 8407334400; 36243671200; 26661940800; 36479287000; 15755814800; 7402624264; 7402515553 ⓘ sukwon@amc.seoul.kr;nrhks@paik.ac.kr; ⓘ INTERNATIONAL JOURNAL OF STROKE ⓘ INT J STROKE ⓘ 1747-4930 1747-4949 16 9 SCIE CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE ⓘ 2021 6.948 11.6 1.38 2025-07-30 ⓘ 20 16 Cilostazol; aspirin; cerebral microbleed; intracerebral hemorrhage; ischemic stroke ⓘ HIGH-RISK; CARDIOVASCULAR EVENTS; PREVENTION; BENEFIT; METAANALYSIS; PICASSO ⓘ aspirin; cerebral microbleed; Cilostazol; intracerebral hemorrhage; ischemic stroke ⓘ Aspirin; Brain Ischemia; Cerebral Hemorrhage; Cilostazol; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Stroke; Treatment Outcome; acetylsalicylic acid; cilostazol; acetylsalicylic acid; antithrombocytic agent; cilostazol; adult; aged; all cause mortality; Article; brain hemorrhage; cardiovascular risk; cerebrovascular accident; comparative study; controlled study; diastolic blood pressure; double blind procedure; drug efficacy; drug safety; female; heart infarction; human; ischemic stroke; major clinical study; male; post hoc analysis; randomized controlled trial; systolic blood pressure; brain hemorrhage; brain ischemia; cerebrovascular accident; complication; treatment outcome ⓘ English 2021 2021-12 10.1177/1747493020941273 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Global impact of COVID-19 on stroke care ⓘ Background The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March-31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, -19.7 to -18.7), 11.5% (95%CI, -12.6 to -10.6), and 12.7% (95%CI, -13.6 to -11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (-20.5%) had greater declines in mechanical thrombectomy volumes than mid- (-10.1%) and low-volume (-8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes. ⓘ Nogueira, Raul G.; Abdalkader, Mohamad; Qureshi, Muhammed M.; Frankel, Michael R.; Mansour, Ossama Yassin; Yamagami, Hiroshi; Qiu, Zhongming; Farhoudi, Mehdi; Siegler, James E.; Yaghi, Shadi; Raz, Eytan; Sakai, Nobuyuki; Ohara, Nobuyuki; Piotin, Michel; Mechtouff, Laura; Eker, Omer; Chalumeau, Vanessa; Kleinig, Timothy J.; Pop, Raoul; Liu, Jianmin; Winters, Hugh S.; Shang, Xianjin; Rodriguez Vasquez, Alejandro; Blasco, Jordi; Arenillas, Juan F.; Martinez-Galdamez, Mario; Brehm, Alex; Psychogios, Marios-Nikos; Lylyk, Pedro; Haussen, Diogo C.; Al-Bayati, Alhamza R.; Mohammaden, Mahmoud H.; Fonseca, Luisa; Luis Silva, M.; Montalverne, Francisco; Renieri, Leonardo; Mangiafico, Salvatore; Fischer, Urs; Gralla, Jan; Frei, Donald; Chugh, Chandril; Mehta, Brijesh P.; Nagel, Simon; Mohlenbruch, Markus; Ortega-Gutierrez, Santiago; Farooqui, Mudassir; Hassan, Ameer E.; Taylor, Allan; Lapergue, Bertrand; Consoli, Arturo; Campbell, Bruce C. V.; Sharma, Malveeka; Walker, Melanie; Van Horn, Noel; Fiehler, Jens; Huy Thang Nguyen; Nguyen, Quoc T.; Watanabe, Daisuke; Zhang, Hao; Le, Huynh V.; Nguyen, Viet Q.; Shah, Ruchir; Devlin, Thomas; Khandelwal, Priyank; Linfante, Italo; Izzath, Wazim; Lavados, Pablo M.; Olavarria, Veronica V.; Silva, Gisele Sampaio; de Carvalho Sousa, Anna Verena; Kirmani, Jawad; Bendszus, Martin; Amano, Tatsuo; Yamamoto, Ryoo; Doijiri, Ryosuke; Tokuda, Naoki; Yamada, Takehiro; Terasaki, Tadashi; Yazawa, Yukako; Morris, Jane G.; Griffin, Emma; Thornton, John; Lavoie, Pascale; Matouk, Charles; Hill, Michael D.; Demchuk, Andrew M.; Killer-Oberpfalzer, Monika; Nahab, Fadi; Altschul, Dorothea; Ramos-Pachon, Anna; Perez de la Ossa, Natalia; Kikano, Raghid; Boisseau, William; Walker, Gregory; Cordina, Steve M.; Puri, Ajit; Kuhn, Anna Luisa; Gandhi, Dheeraj; Ramakrishnan, Pankajavalli; Novakovic-White, Roberta; Chebl, Alex; Kargiotis, Odysseas; Czap, Alexandra; Zha, Alicia; Masoud, Hesham E.; Lopez, Carlos; Ozretic, David; Al-Mufti, Fawaz; Zie, Wenjie; Duan, Zhenhui; Yuan, Zhengzhou; Huang, Wenguo; Hao, Yonggang; Luo, Jun; Kalousek, Vladimir; Bourcier, Romain; Guile, Romain; Hetts, Steven; Al-Jehani, Hosam M.; AlHazzani, Adel; Sadeghi-Hokmabadi, Elyar; Teleb, Mohamed; Payne, Jeremy; Lee, Jin Soo; Hong, Ji Man; Sohn, Sung-Il; Hwang, Yang-ha; Shin, Dong Hoon; Roh, Hong Gee; Edgell, Randy; Khatri, Rakesh; Smith, Ainsley; Malik, Amer; Liebeskind, David; Herial, Nabeel; Jabbour, Pascal; Magalhaes, Pedro; Ozdemir, Atilla Ozcan; Aykac, Ozlem; Uwatoko, Takeshi; Dembo, Tomohisa; Shimizu, Hisao; Sugiura, Yuri; Miyashita, Fumio; Fukuda, Hiroki; Miyake, Kosuke; Shimbo, Junsuke; Sugimura, Yusuke; Beer-Furlan, Andre; Joshi, Krishna; Catanese, Luciana; Abud, Daniel Giansante; Pontes Neto, Octavio; Mehrpour, Masoud; Al Hashmi, Amal; Saqqur, Mahar; Mostafa, Abdulrahman; Fifi, Johanna T.; Hussain, Syed; John, Seby; Gupta, Rishi; Sivan-Hoffmann, Rotem; Reznik, Anna; Sani, Achmad Fidaus; Geyik, Serdar; Akil, Es Comma Ref; Churojana, Anchalee; Ghoreishi, Abdoreza; Saadatnia, Mohammad; Sharifipour, Ehsan; Ma, Alice; Faulder, Ken; Wu, Teddy; Leung, Lester; Malek, Adel; Voetsch, Barbara; Wakhloo, Ajay; Rivera, Rodrigo; Barrientos Iman, Danny Moises; Pikula, Aleksandra; Lioutas, Vasileios-Arsenios; Thomalla, Gotz; Birnbaum, Lee; Machi, Paolo; Bernava, Gianmarco; McDermott, Mollie; Kleindorfer, Dawn; Wong, Ken; Patterson, Mary S.; Fiorot, Jose Antonio; Huded, Vikram; Mack, William; Tenser, Matthew; Eskey, Clifford; Multani, Sumeet; Kelly, Michael; Janardhan, Vallabh; Cornett, Oriana; Singh, Varsha; Murayama, Yuichi; Mokin, Maxim; Yang, Pengfei; Zhang, Xiaoxi; Yin, Congguo; Han, Hongxing; Peng, Ya; Chen, Wenhuo; Crosa, Roberto; Frudit, Michel Eli; Pandian, Jeyaraj D.; Kulkarni, Anirudh; Yagita, Yoshiki; Takenobu, Yohei; Matsumaru, Yuji; Yamada, Satoshi; Kono, Ryuhei; Kanamaru, Takuya; Yamazaki, Hidekazu; Sakaguchi, Manabu; Todo, Kenichi; Yamamoto, Nobuaki; Sonoda, Kazutaka; Yoshida, Tomoko; Hashimoto, Hiroyuki; Nakahara, Ichiro; Cora, Elena; Volders, David; Ducroux, Celina; Shoamanesh, Ashkan; Ospel, Johanna; Kaliaev, Artem; Ahmed, Saima; Rashid, Umair; Rebello, Leticia C.; Pereira, Vitor Mendes; Fahed, Robert; Chen, Michael; Sheth, Sunil A.; Palaiodimou, Lina; Tsivgoulis, Georgios; Chandra, Ronil; Koyfman, Feliks; Leung, Thomas; Khosravani, Houman; Dharmadhikari, Sushrut; Frisullo, Giovanni; Calabresi, Paolo; Tsiskaridze, Alexander; Lobjanidze, Nino; Grigoryan, Mikayel; Czlonkowska, Anna; de Sousa, Diana Aguiar; Demeestere, Jelle; Liang, Conrad; Sangha, Navdeep; Lutsep, Helmi L.; Ayo-Martin, Oscar; Cruz-Culebras, Antonio; Tran, Anh D.; Young, Chang Y.; Cordonnier, Charlotte; Caparros, Francois; Alonso De Lecinana, Maria; Fuentes, Blanca; Yavagal, Dileep; Jovin, Tudor; Spelle, Laurent; Moret, Jacques; Khatri, Pooja; Zaidat, Osama; Raymond, Jean; Martins, Sheila; Thanh Nguyen ⓘ Emory Univ, Grady Mem Hosp, Neurol, Atlanta, GA 30322 USA; Boston Univ, Sch Med, Boston Med Ctr, Radiol, Boston, MA 02118 USA; Boston Univ, Sch Med, Boston Med Ctr, Radiol,Radiat Oncol, Boston, MA 02118 USA; Emory Univ, Grady Mem Hosp, Neurol, Atlanta, GA 30322 USA; Alexandria Univ, Alexandria Univ Hosp, Stroke & Neurointervent Div, Dept Neurol, Alexandria, Egypt; Osaka Natl Hosp, Natl Hosp Org, Stroke Neurol, Osaka, Japan; Army Med Univ, Xinqiao Hosp, Neurol, Chongqing, Peoples R China; Tabriz Univ, Tabriz, Iran; Cooper Univ Hosp, Cooper Neurol Inst, Neurol, Camden, NJ USA; NYU, Sch Med, Neurol, Radiol, New York, NY USA; NYU, Sch Med, Radiol, Neurol, New York, NY USA; Kobe City Med Ctr Gen Hosp, Neurosurg, Kobe, Hyogo, Japan; Kobe City Med Ctr Gen Hosp, Neurol, Kobe, Hyogo, Japan; Fdn Ophtalmol Adolphe Rothschild, Paris, France; Hosp Civils Lyon, Neurol, Lyon, France; Hosp Civils Lyon, Neuroradiol, Lyon, France; Hop Bicetre, Paris, France; Royal Adelaide Hosp, Adelaide, SA, Australia; Hop Univ Strasbourg, Strasbourg, France; Changhai Hosp, Shanghai, Peoples R China; Royal Prince Alfred Hosp, Sydney, NSW, Australia; Wannan Med Coll, Yijishan Hosp, Wuhu, Peoples R China; Hosp Clin Barcelona, Neurol, Barcelona, Spain; Hosp Clin Barcelona, Intervent Neuroradiol, Barcelona, Spain; Hosp Clin Univ, Neurol, Valladolid, Spain; Hosp Clin Univ, Intervent Neuroradiol, Valladolid, Spain; Univ Hosp Basel, Basel, Switzerland; Clin Sagrada Familia, Buenos Aires, DF, Argentina; Emory Univ, Grady Mem Hosp, Neurol, Atlanta, GA 30322 USA; Ctr Hosp Univ Sao Joao, Stroke, Porto, Portugal; Ctr Hosp Univ Sao Joao, Neuroradiol, Porto, Portugal; Hosp Geral de Fortaleza, Fortaleza, Ceara, Brazil; Careggi Univ Hosp, Florence, Italy; Univ Hosp Bern, Neurol, Bern, Switzerland; Univ Hosp Bern, Intervent Neuroradiol, Bern, Switzerland; Swedish Med Ctr, Englewood, CO 80110 USA; MAX Superspecialty Hosp, New Delhi, India; Mem Neurosci Inst, Aventura, FL USA; Univ Hosp Heidelberg, Neurol, Heidelberg, Germany; Univ Hosp Heidelberg, Neuroradiol, Heidelberg, Germany; Univ Iowa, Neurol, Iowa City, IA 52242 USA; Valley Baptist Med Ctr, Neurosci, Harlingen, TX USA; Univ Cape Town, Neurosurg, Cape Town, South Africa; Hop Foch, Neurol, Suresnes, France; Hop Foch, Intervent Neuroradiol, Suresnes, France; Royal Melbourne Hosp, Melbourne, Vic, Australia; Univ Washington, Neurol, Seattle, WA 98195 USA; Univ Washington, Neurosurg, Seattle, WA 98195 USA; Univ Klinikum Hamburg Eppendorf, Intervent Neuroradiol, Hamburg, Germany; Peoples 115 Hosp, Ho Chi Minh City, Vietnam; IMS Tokyo Katsushika Gen Hosp, Tokyo, Japan; Affiliated Hangzhou First Peoples Hosp, Hangzhou, Zhejiang, Peoples R China; Hue Cent Hosp, Hue, Vietnam; Erlanger Med Ctr, Chattanooga, TN USA; Rutgers State Univ, Piscataway, NJ USA; Miami Cardiac & Vasc Inst, Miami, FL USA; Nottingham Univ Hosp, Nottingham, England; Univ Desarrollo, Clin Alemana, Concepcion, Chile; Univ Fed Sao Paulo, Hosp Israelita Albert Einstein, Sao Paulo, Brazil; Hosp Israelita Albert Einstein, Sao Paulo, Brazil; Hackensack Meridian Hlth, Hackensack, NJ USA; Univ Hosp Heidelberg, Neuroradiol, Heidelberg, Germany; Kyorin Univ, Japan 64 Yokohama Brain & Spine Ctr, Hachioji, Tokyo, Japan; Iwate Cent Prefectural Hosp, Morioka, Iwate, Japan; Japanese Red Cross Kyoto Daiichi Hosp, Kyoto, Japan; Kyoto Second Red Cross Hosp, Kyoto, Japan; Japanese Red Cross Kumamoto Hosp, Kumamoto, Japan; Kohnan Hosp, Sendai, Miyagi, Japan; Maine Med Ctr, Neurol, Portland, ME USA; Beaumont Hosp, Dublin, Ireland; Hop Enfants Jesus, Quebec City, PQ, Canada; Yale New Haven Hosp, 20 York St, New Haven, CT 06504 USA; Univ Calgary, Neurol, Calgary, AB, Canada; Univ Hosp Salzburg, Salzburg, Austria; Emory Univ, Sch Med, Atlanta, GA 30322 USA; Valley Hosp, Ridgewood, NJ USA; Univ Hosp Germans Trias & Pujol, Barcelona, Spain; Lau Med Ctr, Beirut, Lebanon; CHU Montreal, Montreal, PQ, Canada; Univ Ottawa, Ottawa, ON, Canada; Univ S Alabama, Mobile, AL USA; Univ Massachusetts, Med Ctr, Amherst, MA 01003 USA; Univ Maryland, College Pk, MD 20742 USA; Riverside Reg Med Ctr, Newport News, VA USA; UT Southwestern, Dallas, TX USA; Henry Ford Hlth Syst, Detroit, MI USA; Metropolitan Hosp, Piraeus, Greece; UTHlth McGovern Med Sch, Houston, TX USA; SUNY Upstate Med Univ Hosp, Syracuse, NY USA; Univ Hosp Ctr Zagreb, Zagreb, Croatia; Westchester Med Ctr, Valhalla, NY USA; Army Med Univ, Xinqiao Hosp, Xian, Shaanxi, Peoples R China; Wuhan 1 Hosp, Wuhan, Hubei, Peoples R China; Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China; Maoming Tradit Chinese Med Hosp, Maoming, Peoples R China; Shaw Shaw Hosp, Hangzhou, Zhejiang, Peoples R China; Mianyang 404 Hosp, Mianyang, Sichuan, Peoples R China; Univ Clin Hosp Ctr Sestre Milosrdnice, Zagreb, Croatia; CHU Nantes, Nantes, France; Univ Calif San Francisco, San Francisco, CA 94143 USA; King Fahad Hosp Univ, Thuwal, Saudi Arabia; King Saud Univ, Riyadh, Saudi Arabia; Tabriz Univ, Tabriz, Iran; Banner Desert Med Ctr, Mesa, AZ USA; Ajou Univ Hosp, Suwon, South Korea; Kyemyung Univ, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Gachon Univ, Gil Hosp, Seongnam, South Korea; Konkuk Univ Hosp, Seoul, South Korea; St Louis Univ, St Louis, MO 63103 USA; Texas Tech Univ, Lubbock, TX 79409 USA; Cooper Univ Hosp, Camden, NJ USA; Univ Miami, Coral Gables, FL 33124 USA; Univ Calif Los Angeles, Los Angeles, CA USA; Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA; Hosp Sao Jose, Rio De Janeiro, Brazil; Eskisehir Osmangazi Univ, Eskisehir, Turkey; Saga Ken Med Ctr Koseikan, Saga, Japan; Saitama Med Ctr, Saitama, Japan; Nara City Hosp, Nara, Japan; Toyonaka City Hosp, Toyonaka, Osaka, Japan; Kagoshima City Hosp, Kagoshima, Japan; Japanese Red Cross Matsue Hosp, Matsue, Shimane, Japan; Shiroyama Hosp, Ota, Japan; Niigata City Gen Hosp, Niigata, Japan; Sugimura Hosp, Kumamoto, Japan; Rush Univ, Med Ctr, Chicago, IL 60612 USA; McMaster Univ, Neurol, Hamilton, ON, Canada; Ribeira Preto Med Sch, Intervent Neuroradiol, Ribeirao Preto, Brazil; Ribeira Preto Med Sch, Neurosci, Ribeirao Preto, Brazil; Shahid Beheshti Univ, Tehran, Iran; Minist Hlth, Khoula Hosp, Muscat, Oman; Hamad Med Corp, Doha, Qatar; Egypt Hamad Med Corp, Alexandria Univ Hosp, Alexandria, Qatar; Mt Sinai Hlth Syst, New York, NY USA; Cleveland Clin Abu Dhabi, Abu Dhabi, U Arab Emirates; WellStar Hlth, Marietta, GA USA; Rambam Hlth Care, Haifa, Israel; Gen Hosp Dr Soetomo, Surabaya, Indonesia; Istanbul Aydin Univ, Istanbul, Turkey; Siriraj Hosp, Bangkok, Thailand; Zanjan Univ, Zanjan, Iran; Isfahan Univ, Esfahan, Iran; Qom Univ, Qom, Iran; Royal North Shore Hosp, St Leonards, NSW, Australia; Christchurch Hosp, Christchurch, New Zealand; Tufts Med Ctr, Neurol, Boston, MA 02111 USA; Tufts Med Ctr, Neurosurg, Boston, MA 02111 USA; Beth Israel Lahey Hlth, Neurol, Boston, MA USA; Beth Israel Lahey Hlth, Intervent Neuroradiol, Boston, MA USA; Inst Neurocirugia Dr Asengo, Neuroradiol, Providencia, Chile; Natl Inst Neurol Sci Lima, Lima, Peru; Univ Toronto, Toronto, ON, Canada; Beth Israel Lahey Hlth, Neurol, Boston, MA USA; Univ Klinikum Hamburg Eppendorf, Neurol, Hamburg, Germany; Univ Texas Hlth San Antonio, San Antonio, TX USA; Univ Hosp Geneva, Geneva, Switzerland; Univ Michigan, Ann Arbor, MI 48109 USA; Royal London Hosp, London, England; Bon Secours Mercy Hlth, Cincinnati, OH USA; Hosp Estadual Cent, Campinas, SP, Brazil; NH Mazumdar Shaw Med Ctr, Bengaluru, Karnataka, India; Univ Southern Calif, Los Angeles, CA 90007 USA; Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA; Bayhealth Med Ctr, Neurol, Delaware, OH USA; Univ Saskatchewan, Neurosurg, Saskatoon, SK, Canada; Med City Plano Texas, Plano, TX USA; St Josephs Univ, Med Ctr, Philadelphia, PA 19131 USA; Jikei Univ, Sch Med, Tokyo, Japan; Univ S Florida, Tampa, FL 33620 USA; Changhai Hosp, Shanghai, Peoples R China; Hangzhou First Peoples Hosp, Hangzhou, Zhejiang, Peoples R China; Linyi City People Hosp, Linyi, Shandong, Peoples R China; First Peoples Hosp, Shanghai, Peoples R China; Zhangzhou Municipal Hosp, Zhangzhou, Peoples R China; Ctr Endovasc Neurol Med, Montevideo, Uruguay; Univ Fed Sao Paulo, Sao Paulo, Brazil; Christian Med Coll & Hosp, Vellore, Tamil Nadu, India; Kawasaki Med Sch, Kawasaki, Kanagawa, Japan; Osaka Red Cross Hosp, Osaka, Japan; Univ Tsukuba, Tsukuba, Ibaraki, Japan; Saiseikai Cent Hosp, Tokyo, Japan; Kinikyochuo Hosp, Sapporo, Hokkaido, Japan; NTT Med Ctr, Tokyo, Japan; Yokohama Shintoshi Neurosurg Hosp, Yokohama, Kanagawa, Japan; Osaka Gen Med Ctr, Osaka, Japan; Osaka Univ, Grad Sch Med, Osaka, Japan; Univ Tokushima, Grad Sch Biomed Sci, Tokushima, Japan; Saiseikai Fukuoka Gen Hosp, Fukuoka, Fukuoka, Japan; Tane Gen Hosp, Osaka, Japan; Osaka Rosai Hosp, Osaka, Japan; Fujita Hlth Univ, Sch Med, Toyoake, Aichi, Japan; Dalhousie Univ, Halifax, NS, Canada; CHU Montreal, Montreal, PQ, Canada; McMaster Univ, Hamilton, ON, Canada; Univ Calgary, Calgary, AB, Canada; Boston Med Ctr, Radiol, Boston, MA USA; Lahore Gen Hosp, Lahore, Pakistan; Hosp Brasilia, Brasilia, DF, Brazil; Univ Toronto, Toronto, ON, Canada; Univ Ottawa, Ottawa, ON, Canada; Rush Univ, Med Ctr, Chicago, IL 60612 USA; UTHlth McGovern Med Sch, Houston, TX USA; Natl & Kapodistrian Univ Athens, Athens, Greece; Monash Med Ctr, Clayton, Vic, Australia; New York Presbyterian Queens, New York, NY USA; Prince Wales Hosp, Hong Kong, Peoples R China; Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada; Baptist Hlth, Little Rock, AR USA; Fdn Policlin Univ A Gemelli, Rome, Italy; Ivane Javakhishvili Tbilisi State Univ, Tbilisi, Georgia; Adventist Hlth Glendale, Glendale, CA USA; Inst Psychiat & Neurol, Warsaw, Poland; Hosp Santa Maria, Santa Maria, RS, Portugal; Leuven Univ Hosp, Leuven, Belgium; Kaiser Permanente, Neurointervent Radiol, Oklahoma City, OK USA; Kaiser Permanente, Neurol, Oklahoma City, CA USA; Univ Oregon, Eugene, OR 97403 USA; Complejo Hosp Univ Albacete, Albacete, Spain; Hosp Univ Ramon & Cajal, Unidad Ictus, Madrid, Spain; Hue Cent Hosp, Hue, Vietnam; Asan Med Ctr, Seoul, South Korea; CHU Lille, Lille, France; La Paz Univ Hosp, Madrid, Spain; Univ Miami, Coral Gables, FL 33124 USA; Cooper Univ Hosp, Camden, NJ USA; Hop Bicetre, Paris, France; Univ Cincinnati, Cincinnati, OH 45221 USA; Bon Secours Mercy Hlth, Toledo, OH USA; CHU Montreal, Montreal, PQ, Canada; Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil; Boston Med Ctr, Radiol, Neurol, Boston, MA USA ⓘ Alhazzani, Adel/AAK-1166-2021; Yaghi, Shadi/Q-8258-2019; Nagel, Simon/AAB-9266-2022; Nakahara, Ichiro/G-3259-2010; renieri, leonardo/AAC-3202-2019; ma, alice/GMW-6710-2022; Qian, Zhong/E-8884-2016; Yamada, Satohi/HHY-9909-2022; mansour, ossama/F-4592-2010; Frisullo, Giovanni/ABC-7406-2021; Martins, Sheila/L-1616-2016; Arenillas, Juan/AAE-1142-2020; Al-Mufti, Fawaz/AAZ-3360-2020; Chandra, Ronil/GPK-0357-2022; AYKAC, OZLEM/D-7439-2018; Silva, Gisele/H-3082-2013; Campbell, Bruce/J-1220-2019; Khatri, Pooja/HDN-0359-2022; Shang, Xianjin/KUD-9843-2024; Khosravani, Houman/JDX-0634-2023; Thomalla, Götz/HPB-8558-2023; Perez de la Ossa, Natalia/MDS-8962-2025; Lavados, Pablo/E-9918-2016; Farooqui, Mudassir/K-8382-2019; Ospel, Johanna/AAK-9939-2020; HWANG, Yang-Ha/F-3068-2013; Pontes-Neto, Octavio/G-4294-2012; Hong, Ji Man/AAE-2686-2022; Palaiodimou, Lina/AFT-5092-2022; Nguyen, Thanh/ABH-4370-2020; Ramos-Pachon, Anna/HHD-1443-2022; Fischer, Urs/HJH-5619-2023; Chen, Wenhuo/MCJ-4295-2025; van Horn, Noel/AAW-5274-2020; Jovin, Tudor/HDM-4330-2022; Nogueira, Raul/LSI-7118-2024; FIOROT, JOSE/KVB-4732-2024; Jovin, Tudor G./HDM-4330-2022; Ozretic, David/MVU-8038-2025; Raz, Eytan/I-5738-2012; Demchuk, Andrew/E-1103-2012; Liebeskind, David/B-1991-2008; Liu, Jianmin/KEI-9744-2024; Monteiro, Rodrigo/HLQ-7233-2023; Hokmabadi, Elyar/L-8926-2017; AHMAD, SAIMA/W-6053-2019; Kühn, Anna/T-5656-2019; bourcier, romain/T-1900-2019; Pandian, Jeyaraj/AAV-5591-2020; mansour, ossama/AFW-1918-2022; Aguiar de Sousa, Diana/J-4105-2013; Hill, Michael/C-9073-2012; Ayo-Martin, Oscar/Q-8541-2017; McDermott, Mollie/AAZ-2358-2021; Berthezene, yves/I-5689-2014; Kleinig, Timothy/AFP-4371-2022; EKER, Omer/H-1930-2019; Chen, Michael/AFN-1941-2022; Kargiotis, Odysseas/MHR-2954-2025; Cordonnier, Charlotte/O-3258-2017; yan, pengfei/E-4784-2016; Alonso de Leciñana, María/C-1464-2017; Sharifipour, Ehsan/M-3282-2016; Pop, Raoul/S-9431-2019; Psychogios, Marios/AFO-4629-2022; Abud, Daniel/K-3431-2014; Janardhan, Vallabh/ABG-3655-2020; Zhang, Xiaoxi/E-1848-2016; Al-Bayati, Alhamza/AAE-7366-2022; de Sousa, Diana/J-4105-2013; Tsivgoulis, Georgios/AAD-5360-2020; Rashid, Umair/LTZ-0527-2024; Mohammaden, Mahmoud/JOK-3317-2023; Shoamanesh, Ashkan/AAS-4682-2021; Calabresi, Paolo/G-8496-2011; Fuentes, Blanca/I-2114-2019; Monteiro, Rodrigo/JFB-4965-2023; Cordina, Steve/HQZ-5341-2023; Sadeghi Hokmabadi, Elyar/L-8926-2017; Malik, Amer/MTB-3558-2025; Matouk, Charles/AAF-7694-2019; Bernava, Gianmarco/ABE-9898-2020; Leung, Thomas/AAU-6475-2021 ⓘ 7102312928; 55881763400; 8548530400; 34568584900; 57220957071; 57205587120; 56157900900; 16444178800; 50562171400; 35110011900; 25625697600; 7402599201; 24341815100; 7004034603; 15623714500; 54385144100; 57200589721; 6506309674; 56184864800; 55036523700; 56009044200; 57075761700; 57225901089; 36784668700; 6603818028; 22938521100; 57203579641; 35307908200; 57247366400; 6506368654; 57189253346; 57211113680; 13607991700; 57225892339; 57193008033; 55193594900; 7004591793; 7202827469; 8409278100; 57224848932; 55351485100; 56218838000; 7102442106; 36197095300; 15825552300; 55202982300; 22034299200; 55385621000; 57193801440; 36443469000; 55337345500; 59275701700; 12241866700; 57210287621; 6603941230; 59157884600; 57649699300; 9842905600; 57037274000; 57951161100; 57222612312; 56091847600; 7006511071; 55871559000; 6603765911; 56177955000; 57188955599; 57204794060; 6506246802; 57225914274; 6602103028; 7006493496; 56567420100; 49562076600; 55447757800; 56754778700; 55807506200; 7102734680; 36667798600; 57208308641; 57208162936; 7402781684; 26321173500; 57212015173; 57026858200; 7006058585; 50361646800; 23467107900; 54681659800; 57208051341; 16417915700; 36664845500; 56998798300; 57194597207; 25721760900; 36196954400; 24314518100; 7006507485; 35574701900; 57224596884; 6602998231; 23967924400; 14420928200; 56320919700; 55945516600; 59052158700; 23989438600; 55613258300; 57225917010; 57197757783; 57194555734; 57211059860; 57678453000; 57216861368; 6506067821; 55146834600; 26633792400; 6603414433; 26039004200; 27867493700; 57225906238; 57204776921; 57222612943; 55963063300; 55729426200; 36479287000; 7402311308; 57669539100; 7005464560; 18233648200; 15136197300; 57222389306; 36624108100; 7004045734; 8445287500; 6603362601; 57188813149; 7006505099; 55842783800; 6602811372; 6603924510; 55230250200; 57020969500; 7003393586; 57201123835; 58853378200; 13605737000; 57210912841; 55754189600; 56084736000; 55618227600; 8279325600; 6504114792; 6507117068; 57218292422; 6506811778; 57226237248; 26030324900; 23974114000; 50561590100; 7501320049; 49962369200; 57221498496; 36017479800; 10440514200; 24343222400; 6602878524; 55830736500; 16234564400; 55241642300; 57216830107; 57205255355; 55476672700; 55892406100; 7102609136; 6603154545; 7006598784; 23670826200; 57191824728; 26431127400; 36114439100; 55879893600; 8610181200; 58100395400; 57204801011; 57200611175; 8239856900; 57206274344; 57209810951; 23566448400; 28567803000; 57197750439; 36656283200; 6602883463; 57222612641; 57208477068; 6603348714; 23995055900; 57222615616; 7202793879; 55448264000; 59662781300; 57190011227; 55612387700; 56687997100; 57226501187; 23990283300; 21933926500; 6506654215; 6701618847; 57222612328; 6603680444; 37004063500; 7004471031; 56479704700; 56770898600; 55181579900; 56459470300; 7202607994; 22954718500; 55603107000; 57204285011; 59826114100; 58867787100; 7005735970; 57203660115; 35772822400; 57041338900; 21934879100; 57207827276; 57215413957; 57225914216; 57208999995; 56176975000; 23668416800; 55427850700; 7406352802; 13403148800; 57203713084; 6701335522; 7401681775; 37064591600; 13605607300; 6506074665; 55550975200; 6507175376; 7102418853; 6506060152; 57201071662; 7003646969; 7102938849; 55781226000; 54781237100; 56927323900; 40661717000; 6701771290; 14038603900; 24479295200; 57225767203; 57225899635; 18436376100; 56905436600; 6505870273; 58876472400; 6507566063; 7102837475; 6603746195; 55411735800; 14013780800; 6701330053; 57210520194; 36084814200; 59709574500 ⓘ thanh.nguyen@bmc.org; ⓘ INTERNATIONAL JOURNAL OF STROKE ⓘ INT J STROKE ⓘ 1747-4930 1747-4949 16 5 SCIE CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE ⓘ 2021 6.948 11.6 9.72 2025-07-30 ⓘ 94 112 COVID-19; stroke care; acute ischemic stroke; mechanical thrombectomy; intracranial hemorrhage; epidemiology ⓘ ⓘ acute ischemic stroke; COVID-19; epidemiology; intracranial hemorrhage; mechanical thrombectomy; stroke care ⓘ COVID-19; Cross-Sectional Studies; Global Health; Hospitalization; Hospitals, High-Volume; Hospitals, Low-Volume; Humans; Intracranial Hemorrhages; Registries; Retrospective Studies; Stroke; Thrombectomy; Time Factors; acute ischemic stroke; Article; bleeding; brain hemorrhage; brain ischemia; cerebrovascular accident; controlled study; coronavirus disease 2019; hospitalization; human; ICD-10; major clinical study; mechanical thrombectomy; observational study; outcome assessment; pandemic; retrospective study; seasonal variation; stroke unit; thrombectomy; brain hemorrhage; cerebrovascular accident; clinical trial; cross-sectional study; global health; high volume hospital; low volume hospital; multicenter study; register; time factor ⓘ English 2021 2021-07 10.1177/1747493021991652 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Model matching inclusion for input/state asynchronous sequential machines with constraint on the length of control input sequences ⓘ In this paper, the model matching inclusion problem for input/state asynchronous sequential machines (ASMs) is studied in the framework of corrective control. The considered ASM receives the external input with various frequencies which hinder full use of inherent reachability of the machine. We elucidate the existence condition and design procedure for a state feedback corrective controller that makes the closed-loop system have the largest behavior contained by a given reference model. To demonstrate the practicality of the proposed control scheme, experimental studies on an asynchronous error detection and correction (EDAC) module are conducted by implementing the controller and machine on the field-programmable gate array (FPGA) system. (C) 2020 The Franklin Institute. Published by Elsevier Ltd. All rights reserved. ⓘ Yang, Jung-Min; Lee, Dong-Eun; Kwak, Seong Woo ⓘ Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehakro, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Control & Instrumentat Engn, 45 Yongsoro, Busan 48513, South Korea ⓘ ⓘ 57208450551; 56605563300; 59816855300 ⓘ jmyang@ee.knu.ac.kr;dolee@knu.ac.kr;ksw@pknu.ac.kr; ⓘ JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS ⓘ J FRANKLIN I ⓘ 0016-0032 1879-2693 358 2 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS ⓘ 2021 4.246 11.6 0 2025-07-30 ⓘ 0 0 ⓘ INPUT/OUTPUT CONTROL; SUPERVISORY CONTROL; FAULT-TOLERANCE; SYSTEMS; DELAY ⓘ ⓘ Closed loop systems; Controllers; Electric machine theory; Field programmable gate arrays (FPGA); Sequential machines; State feedback; Asynchronous sequential machines; Control schemes; Corrective control; Design procedure; Error detection and correction; Existence conditions; Inclusion problem; Reference modeling; Electric machine control ⓘ English 2021 2021-01 10.1016/j.jfranklin.2020.11.024 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Robust corrective control against a class of actuator attacks in input/state asynchronous sequential machines ⓘ A robust corrective control scheme is proposed for input/state asynchronous sequential machines (ASMs) vulnerable to an attacker that is able to switch actuator commands. We first present mathematical descriptions of the outcome of actuator attacks in the dynamics of ASMs, and the diagnosis procedure of each attack using the state bursts. We then address the existence condition and design algorithm for a corrective controller that overcomes any actuator attack in an asynchronous mechanism. Potential reachability of the controlled ASM is fully utilized to surmount temporary corruption of actuator commands. An illustrative example is provided to show the proposed concept and methodology. (C) 2020 The Franklin Institute. Published by Elsevier Ltd. All rights reserved. ⓘ Yang, Jung-Min; Lee, Dong-Eun ⓘ Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehakro, Daegu 41566, South Korea ⓘ ⓘ 57208450551; 56605563300 ⓘ jmyang@ee.knu.ac.kr;dolee@knu.ac.kr; ⓘ JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS ⓘ J FRANKLIN I ⓘ 0016-0032 1879-2693 358 2 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS ⓘ 2021 4.246 11.6 0.46 2025-07-30 ⓘ 5 6 ⓘ DISCRETE-EVENT SYSTEMS; FAULT-TOLERANT CONTROL; SUPERVISORY CONTROL; INPUT/OUTPUT CONTROL; SENSOR; DIAGNOSIS; RECOVERY ⓘ ⓘ Actuators; Sequential machines; Asynchronous sequential machines; Corrective control; Diagnosis procedure; Existence conditions; Mathematical descriptions; Reachability; Electric machine control ⓘ English 2021 2021-01 10.1016/j.jfranklin.2020.12.004 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ State feedback corrective control with a self-repair scheme against transient faults ⓘ This paper presents corrective control of input/state asynchronous sequential machines (ASMs) against transient faults occurring in both ASM and corrective controller. Since not only the ASM but also the controller undergoes unauthorized state transitions as a result of the fault, the ASM is vulnerable to direct damage by transient faults as well as indirect one propagated from the controller under the fault. We address the existence condition and design procedure for a state feedback corrective controller which achieves self-repair against any transient fault, while diagnosing and overcoming those faults infiltrating into the considered ASM. Hardware experiments on field-programmable gate array (FPGA) are provided to validate the applicability of the proposed methodology. (c) 2021 The Franklin Institute. Published by Elsevier Ltd. All rights reserved. ⓘ Yang, Jung-Min; Kwak, Seong Woo ⓘ Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Control & Instrumentat Engn, 45 Yongsoro, Busan 48513, South Korea ⓘ ⓘ 57208450551; 59816855300 ⓘ jmyang@ee.knu.ac.kr;ksw@pknu.ac.kr; ⓘ JOURNAL OF THE FRANKLIN INSTITUTE ⓘ J FRANKLIN I ⓘ 0016-0032 1879-2693 358 16 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS ⓘ 2021 4.246 11.6 0.31 2025-07-30 ⓘ 4 4 ⓘ ASYNCHRONOUS SEQUENTIAL-MACHINES; INPUT/OUTPUT CONTROL; TOLERANCE; DESIGN ⓘ ⓘ Field programmable gate arrays (FPGA); Sequential machines; State feedback; Asynchronous sequential machines; Corrective control; Design procedure; Existence conditions; Hardware experiment; Input state; Repair schemes; Self repair; State transitions; Transient faults; Controllers ⓘ English 2021 2021-10 10.1016/j.jfranklin.2021.09.003 ⓘ 바로가기 바로가기 바로가기 바로가기
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