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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Outer membrane vesicles produced byBurkholderia cepaciacultured with subinhibitory concentrations of ceftazidime enhance pro-inflammatory responses | Burkholderia cepacia is an opportunistic pathogen that infects patients with debilitating underlying diseases. This study investigated the production of outer membrane vesicles (OMVs) byB. cepaciacultured with sub-minimum inhibitory concentrations (MICs) of antibiotics and examined their pathogenic roles bothin vitroandin vivo. B. cepaciaATCC 25416 produced more OMVs under antibiotic stress conditions than controls. OMVs isolated fromB. cepaciacultured in Luria-Bertani (LB) broth (OMVs/LB) induced cytotoxicity and the expression of pro-inflammatory cytokine genes in A549 cells in a dose-dependent manner. Host cell cytotoxicity and pro-inflammatory responses were significantly higher in A549 cells treated withB. cepaciaOMVs cultured with 1/4 MIC of ceftazidime (OMVs/CAZ) than in the cells treated with OMVs/LB, OMVs cultured with 1/4 MIC of trimethoprim/sulfamethoxazole (OMVs/SXT), or OMVs cultured with 1/4 MIC of meropenem. Intratracheal injection ofB. cepaciaOMVs also induced histopathologyin vivoin mouse lungs. Expressions ofIL-1 beta andTNF-alpha genes were significantly up-regulatedin the lungs of mice treated with OMVs/CAZ compared to mice administered other OMVs; the expression of theGRO-alpha gene, however, was significantly up-regulated in OMVs/SXT. In conclusion, OMVs produced byB. cepaciaunder different antibiotic stress conditions induce different host responses that may contribute to the pathogenesis ofB. cepacia. | Kim, Se Yeon; Kim, Mi Hyun; Son, Joo Hee; Kim, Seung Il; Yun, Sung Ho; Kim, Kyeongmin; Kim, Shukho; Shin, Minsang; Lee, Je Chul | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Korea Basic Sci Inst, Drug & Dis Target Team, Ochang, South Korea; Univ Sci & Technol UST, Dept Bioanalyt Sci, Daejeon, South Korea | Kim, Jae-hyung/J-8504-2012; Kim, Tae/B-9921-2013; Kim, Shukho/AGG-1087-2022 | 57209346647; 57203466774; 57201721443; 57206876176; 36828356500; 57216604095; 24341187900; 7401536650; 25930392000 | leejc@knu.ac.kr; | VIRULENCE | VIRULENCE | 2150-5594 | 2150-5608 | 11 | 1 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY | 2020 | 5.882 | 12.4 | 0.47 | 2025-06-25 | 8 | 10 | Burkholderia cepacia; antibiotics; outer membrane vesicle; cytotoxicity; inflammatory response | BURKHOLDERIA-CEPACIA COMPLEX; PSEUDOMONAS-CEPACIA; CYSTIC-FIBROSIS; CIPROFLOXACIN; COLONIZATION; ASSOCIATION; INDUCTION; MEROPENEM; INFECTION; VIRULENCE | antibiotics; Burkholderia cepacia; cytotoxicity; inflammatory response; outer membrane vesicle | A549 Cells; Animals; Anti-Bacterial Agents; Bacterial Outer Membrane; Burkholderia cepacia; Ceftazidime; Female; Humans; Inflammation; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Secretory Vesicles; ceftazidime; interleukin 1beta; monocyte chemotactic protein; sulfamethoxazole; trimethoprim; tumor necrosis factor; antiinfective agent; ceftazidime; animal experiment; animal model; antibiotic sensitivity; Article; Burkholderia cepacia; cell viability assay; controlled study; cytotoxicity; female; gene expression; histopathology; human; human cell; immune response; inflammation; membrane vesicle; minimum inhibitory concentration; mouse; nonhuman; pathogenesis; polyacrylamide gel electrophoresis; real time polymerase chain reaction; RNA isolation; upregulation; A-549 cell line; animal; bacterial outer membrane; Bagg albino mouse; Burkholderia cepacia; drug effect; immunology; microbial sensitivity test; pathogenicity; secretory vesicle | English | 2020 | 2020-01-01 | 10.1080/21505594.2020.1802193 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | A PROSPECTIVE, MULTI-CENTER, COMPARATIVE STUDY TO EVALUATE A NEW NEEDLE (CLEARTIP™) IN EUS-TS FOR PANCREATIC SOLID LESIONS | Cho, Chang-Min; Cho, Jae Hee; Hyun, Jong Jin; Woo, Sang Myung; Lee, Dong Wook; Choi, Jun-Ho; Lee, Kwang Hyuck; Lee, Sang Hyub; Song, Tae Jun; Park, Chang-Hwan; Cho, Eunae; Kim, Seong-Hun; Park, Se Woo; Kim, Tae Hyeon | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Internal Med, Gachon, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Natl Canc Ctr, Ctr Liver & Pancreatobiliary Canc, Goyang, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Internal Med, Cheonan, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Liver Res Inst, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Chonbuk Natl Univ, Med Sch & Hosp, Dept Internal Med, Jeonju, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Dongtan, South Korea; Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea | Kim, TaeHyeon/JOK-7558-2023; Cho, Jae Hee/AAL-8192-2020; Song, Taejun/JVZ-2733-2024; LEE, KYUNG-HAN/HPD-9299-2023 | GASTROINTESTINAL ENDOSCOPY | GASTROINTEST ENDOSC | 0016-5107 | 1097-6779 | 91 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 9.427 | 12.5 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | ARTIFICIAL INTELLIGENCE, TRAINED WITH A ROUGH BINARY CLASSIFICATION, CAN SELECT SIGNIFICANT IMAGES OF CAPSULE ENDOSCOPY | Park, Junseok; Hwang, Youngbae; Lim, Yun Jeong; Nam, Ji Hyung; Oh, Dong Jun; Song, Hyun Joo; Kim, Ki Bae; Kim, Su Hwan; Jung, Min Kyu | Soonchunhyang Univ, Coll Med, Dept Internal Med, Digest Dis Ctr,Inst Digest Res, Seoul, South Korea; Chungbuk Natl Univ, Dept Elect Engn, Cheongju, Chungchungbuk D, South Korea; Dongguk Univ, Ilsan Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Goyang, Gyeonggi Do, South Korea; Jeju Natl Univ, Sch Med, Dept Internal Med, Jeju, Jeju, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, Chungchungbuk D, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, Kyungsangbuk Do, South Korea | KANG, MIN KYU/ACI-8824-2022; KIM, SUHWAN/GSE-0120-2022; Song, hyunjoo/GWC-1292-2022; Kim, Ki Bae/KYQ-0127-2024; Park, Junseok/ABS-0095-2022 | GASTROINTESTINAL ENDOSCOPY | GASTROINTEST ENDOSC | 0016-5107 | 1097-6779 | 91 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 9.427 | 12.5 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Letter | Crucial role of temporary airborne infection isolation rooms in an intensive care unit: containing the COVID-19 outbreak in South Korea | Lee, Shin Yup; Choi, Sun Ha; Park, Ji Eun; Hwang, Soyoon; Kwon, Ki Tae | Kyungpook Natl Univ, Chilgok Hosp, Div Pulm & Crit Care Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Infect Dis, 807 Hokuk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Infect Control, Chilgok Hosp, Daegu, South Korea | Hwang, Soyoon/HHM-5762-2022; Choi, Sun Ha/HPD-7234-2023; Kim, Hanjin/KYP-2633-2024 | 49863712700; 57199723585; 57195437358; 57203160675; 9733850500 | ktkwon@knu.ac.kr; | CRITICAL CARE | CRIT CARE | 1364-8535 | 1466-609X | 24 | 1 | SCIE | CRITICAL CARE MEDICINE | 2020 | 9.097 | 12.5 | 1.14 | 2025-06-25 | 17 | 20 | Air Microbiology; Coronavirus Infections; Cross Infection; Disease Outbreaks; Humans; Infection Control; Intensive Care Units; Pandemics; Patient Isolation; Patients' Rooms; Pneumonia, Viral; Republic of Korea; airborne infection; artificial ventilation; coronavirus disease 2019; critically ill patient; health care personnel; human; intensive care unit; isolation facility; Letter; Middle East respiratory syndrome coronavirus; pneumonia; priority journal; South Korea; tertiary health care; university hospital; Coronavirus infection; cross infection; epidemic; health care facility; infection control; microbiology; pandemic; patient isolation; procedures; South Korea; virus pneumonia | English | 2020 | 2020-05-18 | 10.1186/s13054-020-02944-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Effectiveness of various shapes of Al2O3 nanoparticles on the MHD convective heat transportation in porous medium CVFEM modelling | The influences of Al2O3 nanoparticles with various shapes on thermal characteristics of nanofluid within a permeable space concerning magnetic force have been simulated by means of CVFEM. To form the final PDEs, radiation term has been incorporated. Impacts of magnetic force, radiation constraint, Rayleigh number and shape factor on nanomaterial behaviour have been analysed. Results demonstrate that the higher values of shape factor lead to augmented convective heat transfer. By augmenting the magnetic strength, conductive heat transfer can be predominant than that of the convection. | Vo, Dat D.; Hedayat, Mohammadali; Ambreen, Tehmina; Shehzad, Sabir A.; Sheikholeslami, M.; Shafee, Ahmad; Truong Khang Nguyen | Ton Duc Thang Univ, Div Computat Phys, Inst Computat Sci, Ho Chi Minh City, Vietnam; Ton Duc Thang Univ, Fac Elect & Elect Engn, Ho Chi Minh City, Vietnam; Texas A&M Univ, J Mike Walker Dept Mech Engn 66, College Stn, TX USA; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan; Babol Noshirvani Univ Technol, Dept Mech Engn, Babol Sar, Iran; Babol Noshirvani Univ Technol, Renewable Energy Syst & Nanofluid Applicat Heat T, Babol Sar, Iran; Publ Author Appl Educ & Training, Appl Sci Dept, Coll Technol Studies, Shuwaikh, Kuwait | ; Nguyen, Truong Khang/G-4686-2015; Shehzad, Sabir/J-3885-2014; Sheikholeslami, Mohsen/G-9034-2015; Barzinjy, Azeez/W-6517-2019; Hedayat, Mohammadali/AAA-5994-2019 | 57188559369; 57208982121; 57195420431; 42262831200; 54880733100; 57202423343; 55318932000 | voduydat@tdtu.edu.vn;sabirali@cuisahiwal.edu.pk; | JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | J THERM ANAL CALORIM | 1388-6150 | 1588-2926 | 139 | 2 | SCIE | CHEMISTRY, ANALYTICAL;CHEMISTRY, PHYSICAL;THERMODYNAMICS | 2020 | 4.626 | 12.5 | 3.68 | 2025-06-25 | 41 | 45 | MHD; Nanoparticle's shape; Darcy law; Radiation; Nanofluid; CVFEM | MAGNETOHYDRODYNAMIC NATURAL-CONVECTION; MAGNETIC-FIELD; ENTROPY GENERATION; FORCED-CONVECTION; HYDROCARBON MIXTURES; PCM SOLIDIFICATION; MIXED CONVECTION; WATER NANOFLUID; CAVITY; FLOW | CVFEM; Darcy law; MHD; Nanofluid; Nanoparticle’s shape; Radiation | Alumina; Aluminum oxide; Flow of fluids; Heat convection; Magnetohydrodynamics; Nanofluidics; Nanomagnetics; Porous materials; Convective heat; CVFEM; Darcy law; Heat transportation; Magnetic force; Nanofluids; Nanoparticle’s shape; Porous medium; S shape; Shapes factors; Nanoparticles | English | 2020 | 2020-01 | 10.1007/s10973-019-08501-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | IS FLUOROSCOPY USEFUL FOR GUIDING CROHN'S DISEASE-RELATED STRICTURE DILATION? | Lee, Hyun Seok; Chiorean, Michael V.; Boden, Elisa K.; Lord, James D.; Irani, Shayan S.; Kozarek, Richard A.; Larsen, Michael C.; Ross, Andrew S. | Virginia Mason Med Ctr, Gastroenterol, Seattle, WA 98101 USA; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Boden, Elisa/IVV-0165-2023; Kozarek, Richard/AAF-2695-2020; Chiorean, Michael/AAZ-5305-2021 | GASTROINTESTINAL ENDOSCOPY | GASTROINTEST ENDOSC | 0016-5107 | 1097-6779 | 91 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 9.427 | 12.5 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | New staining method using methionyl-tRNA synthetase 1 for of bile duct cancer | Background and Aims: Identifying malignant biliary strictures using endobiliary brushing cytology specimens is important for treatment decision-making and prognosis prediction. The sensitivity of brushing cytology specimens based on Papanicolaou (Pap) staining is low, which hampers accurate diagnosis of indeterminate strictures. Here, we assessed the diagnostic value of immunohistochemical (IHC) and immunofluorescence (IF) staining for methionyl-tRNA synthetase 1 (MARS1). Methods: Endobiliary brushing cytology specimens were obtained during ERCP from 80 patients with an extrahepatic biliary stricture. Pap and MARS1 IF staining were performed on liquid-based cytology slides derived from these specimens. Sections of bile duct adenocarcinoma and normal bile duct tissue were obtained from 45 patients who underwent surgery for malignant biliary stricture, and MARS1 levels were evaluated by IHC staining. Results: MARS1 IF staining was applied to brushing cytology specimens, and the results showed strong signals in malignant biliary structures but not in the negative for malignancy specimens. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 70.4%, 96.2%, 97.4%, 56.8%, and 78.8%, respectively, for conventional Pap staining and 98.1%, 96.1%, 98.1%, 96.2%, and 97.5%, respectively, for MARS1 IF (P <.0001). When IHC staining was used, MARS1 was detected in 45 bile duct adenocarcinoma sections but not in 15 normal bile duct sections. Moreover, MARS1 mRNA and protein levels were significantly higher in bile duct adenocarcinoma sections according to polymerase chain reaction and Western blot, respectively. Conclusions: The high sensitivity and accuracy of MARS1 IF staining enabled detection of malignancy in patients with indeterminate biliary stricture. Further prospective studies are needed to validate our findings. | Jang, Sung Ill; Kwon, Nam Hoon; Lim, Beom Jin; Nahm, Ji Hae; Park, Joon Seong; Kang, Chang Moo; Park, So Ra; Lee, Su Yun; Kang, Beom Sik; Kim, Sunghoon; Lee, Dong Ki | Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea; Yonsei Univ, Coll Med, Gangnam Severance Hosp, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Surg, Severance Hosp, Seoul, South Korea; Seoul Natl Univ, Med Bioconvergence Res Ctr, Suwon, Gyeonggi Do, South Korea; Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Coll Pharm, Grad Sch Convergence Sci & Technol, Suwon, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Daegu, South Korea | ; Kim, Sunghoon/AAE-8314-2020 | 43761242600; 7003389795; 7201983912; 57193822237; 56610435600; 34968209400; 57215092000; 57218300945; 35082104200; 7601582514; 26029189500 | dklee@yuhs.ac; | GASTROINTESTINAL ENDOSCOPY | GASTROINTEST ENDOSC | 0016-5107 | 1097-6779 | 92 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 9.427 | 12.5 | 0.77 | 2025-06-25 | 14 | 15 | IN-SITU HYBRIDIZATION; INDETERMINATE BILIARY STRICTURES; SINGLE-OPERATOR CHOLANGIOSCOPY; ENDOBILIARY BRUSH CYTOLOGY; PANCREATICOBILIARY MALIGNANCY; PERORAL CHOLANGIOSCOPY; DIAGNOSIS; CHOLANGIOCARCINOMA; OVEREXPRESSION; SENSITIVITY | Bile Duct Neoplasms; Bile Ducts; Bile Ducts, Intrahepatic; Cholangiopancreatography, Endoscopic Retrograde; Humans; Methionine-tRNA Ligase; Prospective Studies; Sensitivity and Specificity; Staining and Labeling; enzyme antibody; methionine transfer RNA ligase; methionyl trna synthetase 1 antibody; unclassified drug; adenocarcinoma; adult; aged; Article; bile duct cancer; brushing cytology; cancer cytodiagnosis; cholestasis; clinical article; controlled study; cytology; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; endoscopic retrograde cholangiopancreatography; female; human; human tissue; immunofluorescence; immunohistochemistry; male; Papanicolaou test; predictive value; priority journal; prospective study; sensitivity and specificity; bile duct; intrahepatic bile duct; staining | English | 2020 | 2020-08 | 10.1016/j.gie.2019.12.017 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | On analysis of Blasius and Rayleigh-Stokes hybrid nanofluid flow under aligned magnetic field | The main focus in this work is to explore the features of laminar Blasius and Rayleigh-Stokes flow with ohmic heating under suspension of hybrid nanofluids. The mathematical model is converted into pair of self-similarity equations by applying appropriate transformations. The reduced similarity equivalences are then exploited numerically by Runge-Kutta-Fehlberg fourth-fifth-order scheme. To know the better description of problem, the flow and energy transport features are explored for distinct values of different factors. The present study concludes that the thermal conductivity of hybrid nanofluid is higher than that of a regular nanofluid in the presence of specified factors. | Kumar, K. Ganesh; Lokesh, H. J.; Shehzad, Sabir A.; Ambreen, Tehmina | SJM Inst Technol, Dept Math, Chitradurga 577502, Karnataka, India; COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; K, Ganesh/AAP-6051-2020; Shehzad, Sabir/J-3885-2014 | 57194870990; 57209512401; 42262831200; 57195420431 | ali_qau70@yahoo.com; | JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | J THERM ANAL CALORIM | 1388-6150 | 1588-2926 | 139 | 3 | SCIE | CHEMISTRY, ANALYTICAL;CHEMISTRY, PHYSICAL;THERMODYNAMICS | 2020 | 4.626 | 12.5 | 1.98 | 2025-06-25 | 29 | 30 | Blasius-Rayleigh-Stokes flow; Hybrid nanofluid; MHD; Ohmic heating; Numerical solutions | UNSTEADY BOUNDARY-LAYERS; THERMAL-CONDUCTIVITY; ROTATING FLOW; HEAT-TRANSFER; ENHANCEMENT; SURFACE; FLUID; MAGNETOHYDRODYNAMICS; SIMULATION; CONVECTION | Blasius–Rayleigh–Stokes flow; Hybrid nanofluid; MHD; Numerical solutions; Ohmic heating | Mathematical transformations; Nanofluidics; Suspensions (fluids); Blasius; Blasiu–rayleigh–stoke flow; Hybrid nanofluid; Magnetic-field; Nanofluid flow; Numerical solution; Rayleigh; Runge-kutta-fehlberg; Self-similarities; Stokes flows; Magnetohydrodynamics | English | 2020 | 2020-02 | 10.1007/s10973-019-08576-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Rgx365, a Rare Protopanaxatriol-Type Ginsenoside Fraction from Black Ginseng, Suppresses Inflammatory Gene iNOS via the Iinhibition of p-STAT-1 and NF-κB | Black ginseng (BG), which is ginseng that has been steamed and dried nine times, and its main protopanaxatriol-type ginsenosides Rg4, Rg6, Rh4, and Rg2 have been reported to exhibit various forms of biological activity, including antiseptic, antidiabetic, wound-healing, immune-stimulatory, and anti-oxidant activity. The aim of the this study was to examine the effects of Rgx365 (a rare protopanaxatriol-type ginsenoside fraction; Rg2, Rg4, Rg6, Rh1, and Rh4) on heme oxygenise-1 (HO-1) induction and on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-)2 in lipopolysaccharide (LPS)-activated human pulmonary artery endothelial cells (HPAECs). Rgx365 was tested to determine its effect on iNOS protein expression and inflammatory markers (interleukin [IL]-1 beta and tumor necrosis factor [TNF]-alpha) in the lung tissue of LPS-treated mice. The results showed that Rgx365 induced the expression of HO-1, reduced LPS-activated NF-kappa B-luciferase activity, and inhibited iNOS/NO and COX-2/PGE2, which contributed to the inhibition of STAT-1 phosphorylation. In particular, Rgx365 induced the translocation of Nrf2 from the cytosol to the nucleus by increasing Nrf2-ARE activity and decreased IL-1 beta production in LPS-activated HPAECs. This reduction in iNOS/NO expression due to Rgx365 was reversed by siHO-1 RNA transfection. In LPS-treated mice, Rgx365 significantly reduced lung tissue iNOS protein levels and TNF-alpha levels in the bronchoalveolar lavage fluid. In conclusion, these findings indicate that Rgx365 has a critical anti-inflammatory effect due to its ability to regulate iNOS via the inhibition of p-STAT-1 and NF-kappa B, and thus it may be suitable for the treatment of inflammatory disease. | Jeong, So Yeon; Kim, Ji-Eun; Song, Gyu-Yong; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, BK21 Plus KNU Multiom Based Creat Drug Res Team, Coll Pharm, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejon 34134, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 58443839300; 55812501900; 7402253074; 16021543200 | gysong@cnu.ac.kr;baejs@knu.ac.kr; | AMERICAN JOURNAL OF CHINESE MEDICINE | AM J CHINESE MED | 0192-415X | 1793-6853 | 48 | 5 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE;MEDICINE, GENERAL & INTERNAL | 2020 | 4.667 | 12.5 | 0.7 | 2025-06-25 | 6 | 7 | Rgx365; Endothelium; iNOS; p-STAT-1 | CARBON-MONOXIDE; INDUCED SEPSIS; RELEASE; COX-2; MODEL | Endothelium; iNOS; p-STAT-1; Rgx 3 6 5 | Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Gene Expression; Ginsenosides; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Interleukin-1beta; Luciferases; Male; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Panax; Phosphorylation; Phytotherapy; STAT1 Transcription Factor; beta actin; complementary DNA; cyclooxygenase 2; ginsenoside; ginsenoside Rgx 365; heme oxygenase 1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; lamin B; lipopolysaccharide; luciferase; prostaglandin E2; reactive oxygen metabolite; STAT1 protein; transcription factor Nrf2; tumor necrosis factor; unclassified drug; antiinflammatory agent; autacoid; cyclooxygenase 2; ginsenoside; heme oxygenase 1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; luciferase; STAT1 protein; STAT1 protein, human; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; bronchoalveolar lavage fluid; controlled study; cytosol; defense mechanism; drug effect; endothelial cell line; enzyme inhibition; ginseng; human; human cell; human pulmonary artery endothelial cell; luciferase assay; lung injury; lung lavage; lung parenchyma; male; mouse; nonhuman; protein expression; protein phosphorylation; proton transport; umbilical vein endothelial cell; animal; C57BL mouse; chemistry; drug effect; gene expression; genetics; inflammation; isolation and purification; metabolism; Panax; phosphorylation; phytotherapy | English | 2020 | 2020 | 10.1142/s0192415x20500536 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | THE PREVALENCE, NATURAL COURSE, AND CLINICAL PRACTICE OF UPPER GASTROINTESTINAL SUBEPITHELIAL TUMORS IN KOREA | Choe, Younghee; Cho, Yu Kyung; Kim, Gwang Ha; Kim, Ji Hyun; Kim, Tae Hyeon; Kim, Eun Soo; Choi, Eun Kwang; Choi, Jun-Ho; Kim, Seong-Hun; Kim, Do Hoon | Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Pusan Natl Univ Hosp, Busan, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Jeju Natl Univ, Sch Med, Jeju, South Korea; Dankook Univ, Coll Med, Cheonan, South Korea; Chonbuk Natl Univ Hosp, Jeonju, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea | Kim, Gwang Ha/ABF-3932-2021; Kim, TaeHyeon/JOK-7558-2023; Kim, Soon Hee/GXF-6736-2022 | GASTROINTESTINAL ENDOSCOPY | GASTROINTEST ENDOSC | 0016-5107 | 1097-6779 | 91 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 9.427 | 12.5 | 2 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Climate-driven constraints in sustaining future wheat yield and water productivity | Conceptualising wheat growth, yield and water productivity (WP) relationships with future climate change is necessary for sustainable agriculture and food security. This study assessed the climate change influences on wheat yield and WP with and without CO2 enrichment under semi-arid conditions. Statically bias-corrected climate change projections were coupled with AquaCrop model v5.0 to predict the wheat growth-span, yield and WP variations in Punjab, Pakistan. Acute wheat seasonal warming, characterised by sharp T-min increase than T-max, and substantial rainfall drops lead to short growth-spans and prompt ample yield reductions. However, CO2 enrichment promises to offset the negative wheat yield trends. Higher wheat yield vulnerability was detected for the late-season climate warming during the grain-filling stage. Wheat yield reduction and the limited influence of beneficial CO2-enrichment caused the future WP to decline consistently. CO2 enrichment featured a noteworthy mitigation role in sustaining and improving future wheat yield and WP. In conclusion, CO2 enrichment could impart some beneficial influences to wheat yield and WP, but would not fully eliminate the negative impacts of future climate warming under semi-arid conditions of Punjab, Pakistan. The reliability of such estimates demands a further in-depth examination of crop yield responses to carbon-temperature-water interactions under various field management conditions. | Ahmad, Mirza Junaid; Iqbal, Muhammad Anjum; Choi, Kyung Sook | Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Leibniz Ctr Agr Landscape Res, Inst Landscape Syst Anal, Muncheberg, Germany; Kyungpook Natl Univ, Inst Agr Sci & Technol, Dept Agr Civil Engn, Daegu, South Korea | Ahmad, Mirza/AAD-5982-2020 | 57201479907; 58592873000; 54392662900 | ks.choi@knu.ac.kr; | AGRICULTURAL WATER MANAGEMENT | AGR WATER MANAGE | 0378-3774 | 1873-2283 | 231 | SCIE | AGRONOMY;WATER RESOURCES | 2020 | 4.516 | 12.6 | 1.73 | 2025-06-25 | 24 | 23 | Climate change; Wheat yield; Water productivity; Semiarid condition | FAO CROP MODEL; BIAS-CORRECTION; AQUACROP MODEL; WINTER-WHEAT; CHANGE IMPACT; PERFORMANCE ASSESSMENT; IRRIGATION TECHNIQUES; USE EFFICIENCY; RIVER-BASINS; INDUS BASIN | Climate change; Semiarid condition; Water productivity; Wheat yield | Triticum aestivum; Agriculture; Carbon dioxide; Climate models; Food supply; Productivity; Climate change projections; Field management; Seasonal warming; Semi-arid conditions; Sustainable agriculture; Water interactions; Water productivity; Wheat yield; Climate change | English | 2020 | 2020-03-31 | 10.1016/j.agwat.2019.105991 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Compact vari-focal augmented reality display based on ultrathin, polarization-insensitive, and adaptive liquid crystal lens | Despite the recent advances in augmented reality (AR), which has shown the potential to significantly impact on our daily lives by offering a new way to manipulate and interact with virtual information, minimizing visual discomfort due to the vergence-accommodation conflict remains a challenge. Emerging AR technologies often exploit focus-tunable optics to address this problem. Although they demonstrated improved depth perception by enabling proper focus cues, a bulky form factor of focus-tunable optics prevents their use in the form of a pair of eyeglasses. Here, we propose a novel optical configuration for a compact vari-focal AR display which deliberately utilizes the zeroth and first diffraction orders of the LC lens to produce two foci: one for a real object and the other for a virtual object with addressable focal planes. The prototype AR glasses can adjust the accommodation distance of the virtual image, mitigating the vergence-accommodation conflict without substantially compromising the form factor or image quality. In addition, we describe the design, fabrication, and characterization of an ultrathin, polarization-insensitive focus-tunable liquid crystal (LC) diffractive lens with a large aperture, a low weight, and a low operating voltage. We show that the polarization dependence of the lens, which is an inherent optical property of LC lenses, can be insensitive using the trilayer birefringent materials and by aligning the optical axes of each birefringent material at a specific angle. The polarization insensitivity eliminates the need for a polarizer, thus further reducing the form factor of the optical system. This novel approach offers significantly reduced complexity for designing AR glasses with addressable focal planes. These technologies for ultrathin lens and AR display show promising potential for developing compact optical systems in various applications. | Kumar, Mareddi Bharath; Kang, Daekyung; Jung, Jihoon; Park, Hongsik; Hahn, Joonku; Choi, Muhan; Bae, Jin-Hyuk; Kim, Hyunmin; Park, Jonghoo | Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; DGIST, Compan Diagnost & Med Technol Res Grp, Daegu 42988, South Korea | Kim, Hyunmin/D-2875-2011; Mareddi, Bharathkumar/HSA-7535-2023 | 57190606826; 57211869035; 56467575400; 35366976200; 10142501600; 7402093793; 35326180700; 57192552925; 57196408322 | jonghoopark@knu.ac.kr; | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 128 | SCIE | OPTICS | 2020 | 4.836 | 12.6 | 2.68 | 2025-06-25 | 39 | 40 | Augmented reality; Vergence-accommodation conflict; Focus tunable lens; Polarization-insensitive; See-through near-eye display | HEAD-MOUNTED DISPLAY; FRESNEL LENS; DISTANCE PERCEPTION; STEREO; CUES | Augmented reality; Focus tunable lens; Polarization-insensitive; See-through near-eye display; Vergence-accommodation conflict | Approximation theory; Augmented reality; Birefringence; Depth perception; Focusing; Glass; Liquid crystals; Optical systems; Polarization; Birefringent materials; Inherent optical properties; Optical configurations; Polarization dependence; Polarization insensitivity; Polarization-insensitive; Tunable lens; Vergences; Optical instrument lenses | English | 2020 | 2020-05 | 10.1016/j.optlaseng.2020.106006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of multi-dimensional thread geometry using depth-resolved swept-source optical coherence tomography for assessment of dental implant fabrication | The geometrical characteristics of dental implants, such as thread depth and width, facing angle, pitch, and surface roughness, are important to assess their stability and osseointegration after implant surgery. Herein, we demonstrate the potential use of depth-resolved swept-source optical coherence tomography (SS-OCT) to assess the structural quality of widely used dental implants. The implemented SS-OCT system was centered at a wavelength of 1300 nm with a 100 nm full-width at half-maximum. Four dental implants with different structural formations fabricated using either titanium or ceramic were visualized. Qualitative assessments were performed using boundary flattening with an amplitude-profiling algorithm to emphasize and compare the thread depths, surface roughness, and inner structures of the experimental samples. Cross-sectional and volumetric OCT data clearly revealed the depth, width, and pitch of the dental implants, and especially, the quantitative assessment of axial and lateral thread depth unobtainable using conventional inspection methods was successfully conducted. The depth of thread was measured using a depth-directional intensity profile. In conclusion, the high-resolution SS-OCT system could be utilized to improve the quality assurance of dental implant products through multi-plane assessment. | Lee, Jaeyul; Han, Sangyeob; Hwang, Junho; Park, Sungjo; Jeon, Deokmin; Kim, Kanghae; Wijesinghe, Ruchire Eranga; Lee, Kyu-Bok; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Laser Applicat Ctr, Inst Adv Convergence Technol, 70 Dongnar Ro, Daegu 41061, South Korea; Kyungil Univ, Coll Engn, Dept Biomed Engn, 50 Gamasil Gil, Gyongsan 38428, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, A3DI, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, 2177 Dalgubeol Daero, Daegu 41940, South Korea | Wijesinghe, Ruchire/K-3797-2016; Lee, Junsoo/IUO-9627-2023 | 57188689420; 57193695305; 57204783286; 7501826338; 57204570554; 57188689605; 56018152300; 15925571200; 24171094000; 7601373350 | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 127 | SCIE | OPTICS | 2020 | 4.836 | 12.6 | 0.49 | 2025-06-25 | 6 | 7 | Swept-source optical coherence tomography; Thread geometry; Dental implant; Ceramic; Titanium | RAY PHOTOELECTRON-SPECTROSCOPY; ELECTRON-MICROSCOPY; OSSEOINTEGRATION; ROUGHNESS; DOMAIN; BONE; TOPOGRAPHY; SURFACES | Ceramic; Dental implant; Swept-source optical coherence tomography; Thread geometry; Titanium | Ceramic Prosthetics; Dental prostheses; Fabrication; Geometry; Metal implants; Quality assurance; Surface roughness; Titanium; Tomography; Ceramic; Conventional inspection methods; Geometrical characteristics; Qualitative assessments; Quantitative assessments; Structural formation; Structural qualities; Swept source optical coherence tomographies; Optical tomography | English | 2020 | 2020-04 | 10.1016/j.optlaseng.2019.105951 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Additivity of Ileal Amino Acid Digestibility in Diets Containing Corn, Soybean Meal, and Corn Distillers Dried Grains with Solubles for Male Broilers | Simple Summary There is limited information on the additivity on ileal digestibility of amino acids (AAs) in poultry diets containing corn distillers dried grains with solubles. The aim of this study was to test additivity of two types of ileal digestibility of AAs in mixed diets containing corn, soybean meal, and corn distillers dried grains with solubles in male Ross 308 broiler chickens. The apparent ileal digestibility of some amino acids in feed ingredients used in the study was not additive in mixed diets, whereas the standardized ileal digestibility of most amino acids was additive. Based on the results, standardized ileal digestibility values are more additive in poultry diets containing various feed ingredients compared with apparent ileal digestibility values. The aim was to test additivity of apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of amino acids (AAs) in mixed diets for Ross 308 broiler chickens. Two hundred and eighty-eight, 20-d-old male broiler chickens were assigned to one of six diets, with six birds per cage using a randomized complete block design. The diets consisted of a nitrogen-free diet, three diets containing corn, soybean meal (SBM), and corn distillers dried grains with solubles (CDDGS) as the sole source of nitrogen, respectively, and two mixed diets containing corn, SBM or CDDGS. Chromic oxide was added to the diets as an indigestible index. On day 24, birds were euthanized for ileal digesta collection. Relative proportion of the basal endogenous loss of AAs to total ileal outflow of AAs in corn was greater (p< 0.05) than that of SBM and CDDGS. For the corn-SBM and corn-SBM-CDDGS mixed diets, the AID of AAs differed (p< 0.05) from the predicted values. No difference was observed between the measured and predicted SID of AA. In conclusion, the SID of AAs is more additive in mixed diets containing corn, SBM, or CDDGS compared to AID values. | An, Su Hyun; Sung, Jung Yeol; Kang, Hwan-Ku; Kong, Changsu | Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Konkuk Univ, Monogastr Anim Feed Res Inst, Seoul 05029, South Korea; RDA, Natl Inst Anim Sci, Inst Poultry Sci, Pyeongchang 25340, South Korea | ; 안, 수현/JFK-5079-2023 | 57216974969; 57209716557; 24166849700; 36027521600 | woobi89@gmail.com;jungyeolsung@gmail.com;magic100@korea.kr;changsukong@knu.ac.kr; | ANIMALS | ANIMALS-BASEL | 2076-2615 | 10 | 6 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES | 2020 | 2.752 | 12.7 | 1.36 | 2025-06-25 | 18 | 16 | additivity; amino acids; ileal digestibility; feed ingredients; broiler | FEED INGREDIENTS; CHICKENS; FEEDSTUFFS; APPARENT; ENERGY; SWINE | Additivity; Amino acids; Broiler; Feed ingredients; Ileal digestibility | arginine; glycine; histidine; leucine; phenylalanine; amino acid composition; animal experiment; Article; broiler; chemical analysis; controlled study; diet therapy; digestion; maize; male; nonhuman; predictive value; protein degradation; soybean; soybean meal | English | 2020 | 2020-06 | 10.3390/ani10060933 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Emergence of Third-Generation Cephalosporin-Resistant Morganella morganii in a Captive Breeding Dolphin in South Korea | Simple Summary The emergence of antimicrobial resistance (AMR) has become an important consideration in animal health, including marine mammals, and several potential zoonotic AMR bacterial strains have been isolated from wild cetacean species. Although the emergence of AMR bacteria can be assumed to be much more plausible in captive than in free-ranging cetaceans owing to their frequent contact with humans and antibiotic treatments, the spread and its impacts of AMR bacteria in captive animals have not been adequately investigated yet. Here in this study, we present evidence on the presence of multidrug-resistant potential zoonotic bacteria which caused fatal infection in a captive dolphin bred at a dolphinarium in South Korea. The emergence of antimicrobial resistant (AMR) strains of Morganella morganii is increasingly being recognized. Recently, we reported a fatal M. morganii infection in a captive bottlenose dolphin (Tursiops truncatus) bred at a dolphinarium in South Korea. According to our subsequent investigations, the isolated M. morganii strain KC-Tt-01 exhibited extensive resistance to third-generation cephalosporins which have not been reported in animals. Therefore, in the present study, the genome of strain KC-Tt-01 was sequenced, and putative virulence and AMR genes were investigated. The strain had virulence and AMR genes similar to those of other M. morganii strains, including a strain that causes human sepsis. An amino-acid substitution detected at the 86th residue (Arg to Cys) of the protein encoded by ampR might explain the extended resistance to third-generation cephalosporins. These results indicate that the AMR M. morganii strain isolated from the captive dolphin has the potential to cause fatal zoonotic infections with antibiotic treatment failure due to extended drug resistance, and therefore, the management of antibiotic use and monitoring of the emergence of AMR bacteria are urgently needed in captive cetaceans for their health and conservation. | Park, Seon Young; Lee, Kyunglee; Cho, Yuna; Lim, Se Ra; Kwon, Hyemin; Han, Jee Eun; Kim, Ji Hyung | Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon 34141, South Korea; Chungnam Natl Univ, Coll Agr & Life Sci, Div Anim & Dairy Sci, Daejeon 34134, South Korea; Natl Inst Fisheries Sci, Cetacean Res Inst, Ulsan 44780, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Aquat Biomed, Daegu 41566, South Korea | Kim, Ji Hyung/B-7321-2011 | 57208480038; 56305609800; 57202705850; 57200415399; 57219719164; 57214671240; 57225000204 | lovesun139@kribb.re.kr;moby19@korea.kr;tnvlfldj@gmail.com;dlatpfk13@kribb.re.kr;hena0922@kribb.re.kr;jehan@knu.ac.kr;kzh81@kribb.re.kr; | ANIMALS | ANIMALS-BASEL | 2076-2615 | 10 | 11 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES | 2020 | 2.752 | 12.7 | 1.7 | 2025-06-25 | 15 | 17 | marine mammal health; cetacean; antimicrobial resistance; ampR; zoonotic infection | MOLECULAR CHARACTERIZATION; BETA-LACTAMASE; ISOLATE | AmpR; Antimicrobial resistance; Cetacean; Marine mammal health; Zoonotic infection | amoxicillin; amoxicillin plus clavulanic acid; ampicillin; aztreonam; cefalotin; cefazolin; cefotaxime; cefoxitin; ceftazidime; cefuroxime; cephalosporin; ciprofloxacin; cotrimoxazole; erythromycin; gentamicin; imipenem; piperacillin plus tazobactam; polymyxin B; amino acid substitution; antibiotic resistance; Article; breeding; bronchopneumonia; Cetacea; disk diffusion; female; gene sequence; human; marine mammal; minimum inhibitory concentration; Morganella morganii; nonhuman; nucleotide sequence; phenotype; phylogenetic tree; Proteus mirabilis; sepsis; South Korea; toothed whale; virulence; zoonosis | English | 2020 | 2020-11 | 10.3390/ani10112052 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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