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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Up- or Downregulation of Melanin Synthesis Using Amino Acids, Peptides, and Their Analogs | Harmonious synthesis and distribution of melanin in the skin contribute to the expression of beauty and the maintenance of health. When skin pigmentary disorders occur because of internal or external factors or, when there is a need to artificially increase or reduce the pigmentation level of the skin for aesthetic or therapeutic purposes, various pharmacological therapies are applied but the results are not always satisfactory. Studies have been conducted to improve the efficacy and safety of these treatment strategies. In this review, we present the latest studies regarding peptides and related compounds that may be useful in artificially increasing or reducing skin melanin levels. Certain analogs of alpha-melanocyte stimulating hormone (MSH) and oligopeptides with the sequences derived from the hormone were shown to promote melanin synthesis in cells and in vivo models. Various amino acids, peptides, their analogs, and their hybrid compounds with other chemical moieties were shown to inhibit tyrosinase (TYR) catalytic activity or downregulate TYR gene expression. Certain peptides were shown to inhibit melanosome biogenesis or induce autophagy, leading to decreased pigmentation. In vivo and clinical evidence are available for some compounds, including [Nle(4)-(D)-Phe(7)]-alpha-MSH, glutathione disulfide, and glycinamide hydrochloride. For many other compounds, additional studies are required to verify their efficacy and safety in vivo and in clinical trials. The accumulating information regarding pro- and antimelanogenic activity of peptides and related compounds will lead to the development of novel drugs for the treatment of skin pigmentary disorders. | Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 8 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2020 | 6.081 | 11.8 | 0.79 | 2025-06-25 | 28 | 31 | pigmentation; melanin; peptide; amino acid; tyrosinase; inhibitor; melanocortin 1 receptor; agonist; antagonist; melanogenesis; melanosome biogenesis; autophagy | MELANOCYTE-STIMULATING HORMONE; P-COUMARIC ACID; SHORT-SEQUENCE OLIGOPEPTIDES; INHIBITORY CYCLIC-PEPTIDES; ALPHA-MELANOTROPIN; L-TYROSINE; BETA-LACTOGLOBULIN; CONCENTRATING HORMONE; BIOLOGICAL-ACTIVITIES; SIGNALING PATHWAYS | Agonist; Amino acid; Antagonist; Autophagy; Inhibitor; Melanin; Melanocortin 1 receptor; Melanogenesis; Melanosome biogenesis; Peptide; Pigmentation; Tyrosinase | English | 2020 | 2020-09 | 10.3390/biomedicines8090322 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Coordinated static control of asynchronous sequential machines | This paper considers static corrective control of asynchronous sequential machines (ASMs). While static corrective controllers are more efficient than dynamics ones as their implementation needs no memory elements, they have restrictive existence conditions in association with transient states. To alleviate this drawback, we propose a framework of coordinated static control for ASMs. A number of single static controllers are designed to achieve local objectives and the coordinator selects the active controller among them based on the external input and state feedback so that the overall behavior of the closed-loop system matches that of a reference model. Compared with previous static controllers, the existence condition is much improved with mild degradation of design complexity. (C) 2019 Elsevier Ltd. All rights reserved. | Yang, Jung-Min | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea | 57208450551 | jmyang@ee.knu.ac.kr; | AUTOMATICA | AUTOMATICA | 0005-1098 | 1873-2836 | 113 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 5.944 | 11.9 | 0.07 | 2025-06-25 | 1 | 1 | Asynchronous sequential machines (ASMs); Static control; Coordinated control; Model matching | OUTPUT-FEEDBACK CONTROL | Asynchronous sequential machines (ASMs); Coordinated control; Model matching; Static control | Closed loop systems; Controllers; Sequential machines; State feedback; Asynchronous sequential machines; Co-ordinated control; Corrective control; Existence conditions; Model matching; Reference modeling; Static control; Static controllers; Electric machine control | English | 2020 | 2020-03 | 10.1016/j.automatica.2019.108795 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Electrospun poly(vinyl alcohol)/silver nanoparticle/carbon nanotube multi-composite nanofiber mat: Fabrication, characterization and evaluation of thermal, mechanical and antibacterial properties | Multi-composite nanofiber mats composed of poly(vinyl alcohol), silver nanoparticle and carbon nanotube were fabricated by electrospinning method. Transmission electron microscopy and X-ray diffraction investigations supported the coexistence of silver nanoparticle, carbon nanotube and poly(vinyl alcohol) matrix in which silver nanoparticle and carbon nanotube were well distributed. The study showed that the thermal stability was enhanced by silver nanoparticle and carbon nanotube each, while carbon nanotube also increased tensile strength of the multi-composite. It was also found that the fabricated poly(vinyl alcohol)/silver nanoparticle composite nanofiber mat demonstrated antibacterial activity, which was intensified due to inclusion of carbon nanotube. | Islam, Md Shahidul; Naz, Ashrafun Nazneen; Alam, Md Nur; Das, Ajoy Kumar; Yeum, Jeong Hyun | McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; Shahabuddin Med Coll, Dept Microbiol, Dhaka 1212, Bangladesh; Lakehead Univ, Biorefining Res Inst, 1294 Balmoral St, Thunder Bay, ON P7B 5Z5, Canada; Univ Dhaka, Dept Appl Chem & Chem Engn, Dhaka 1000, Bangladesh; Kyungpook Natl Univ, Dept Adv Organ Mat Sci & Engn, Daegu 702701, South Korea | Das, Ajoy/E-9728-2012; Islam, Md Shahidul/ABC-8944-2021 | 59811577500; 57214822720; 57190659349; 57198696172; 6602257098 | shahidul@du.ac.bd; | COLLOID AND INTERFACE SCIENCE COMMUNICATIONS | COLLOID INTERFAC SCI | 2215-0382 | 35 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, COATINGS & FILMS;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 4.914 | 11.9 | 1.46 | 2025-06-25 | 30 | 32 | Multi-composite; Thermal stability; Mechanical property; Antibacterial activity; Electrospun nanofiber mat; Silver nanoparticle; Carbon nanotube | LIQUID MARBLES; GRAPHENE OXIDE; PARTICLES | Antibacterial activity; Carbon nanotube; Electrospun nanofiber mat; Mechanical property; Multi-composite; Silver nanoparticle; Thermal stability | English | 2020 | 2020-03 | 10.1016/j.colcom.2020.100247 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Fault tolerant control of asynchronous sequential machines with transient faults in non-fundamental mode | This paper addresses fault tolerant corrective control of asynchronous sequential machines (ASMs) against transient faults causing unauthorized state transitions. While the prior work considers only those kinds of faults that comply with fundamental mode operations, the constraint is relaxed in this study. Hence the transient faults may occur not only in fundamental mode, or when the machine stays at a stable state, but also in non-fundamental mode, or when the machine passes through transient states. The condition for overcoming transient faults occurring in non-fundamental mode turns out to be stricter than the case of fundamental mode. A novel scheme of corrective control is presented to make the closed-loop system immune against any fault occurrence in non-fundamental mode. An illustrative example is provided to demonstrate the synthesis procedure of the proposed corrective controller. (C) 2019 Elsevier Ltd. All rights reserved. | Yang, Jung-Min | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea | 57208450551 | jmyang@ee.knu.ac.kr; | AUTOMATICA | AUTOMATICA | 0005-1098 | 1873-2836 | 112 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 5.944 | 11.9 | 0.21 | 2025-06-25 | 3 | 4 | Asynchronous sequential machines (ASMs); Corrective control; Fault tolerance; Non-fundamental mode | FRAMEWORK | Asynchronous sequential machines (ASMs); Corrective control; Fault tolerance; Non-fundamental mode | Closed loop systems; Fault tolerance; Sequential machines; Asynchronous sequential machines; Corrective control; Fault tolerant control; Fundamental modes; State transitions; Synthesis procedure; Transient faults; Transient state; Electric machine control | English | 2020 | 2020-02 | 10.1016/j.automatica.2019.108663 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Heated tobacco products: Cigarette complements, not substitutes (vol 204, 107576, 2019) | Hwang, Jun Hyun; Ryu, Dong Hee; Park, Soon-Woo | Catholic Univ Daegu, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Reg Canc Ctr, Dept Prevent Med, Daegu, South Korea | 36129337200; 57204067251; 14021980900 | parksw@cu.ac.kr; | DRUG AND ALCOHOL DEPENDENCE | DRUG ALCOHOL DEPEN | 0376-8716 | 1879-0046 | 208 | SCIE;SSCI | PSYCHIATRY;SUBSTANCE ABUSE | 2020 | 4.492 | 11.9 | 0 | 2025-06-25 | 1 | 0 | erratum | English | 2020 | 2020-03-01 | 10.1016/j.drugalcdep.2020.107872 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Ideal ratios of standardized ileal digestible methionine, threonine, and tryptophan relative to lysine for male broilers at the age of 1 to 10 days | The objective of this study was to develop ideal amino acid (AA) ratios based on the standardized ileal digestible (SID) lysine, methionine (in the presence of 4.3 g SID cysteine/kg), threonine, and tryptophan requirements, for 10-day-old male broiler chickens. Three experiments were conducted using Ross 308 male chicks fed diets based on corn, soybean meal, and additional graded crystalline AA with 228 g/kg of crude protein. Each diet contained the same amount of basal diets including corn, soybean meal, corn starch, and soybean oil, and graded AA were substituted at the expense of L-glutamic acid in order to keep all diets isonitrogenous. A total of 720 birds were allocated to 6 treatment groups, with 15 birds per cage and 8 cages per treatment using a randomized complete block design. Body weight and group feed intake were measured on day 10. The dietary SID AA levels in each experiment ranged from 2.9 to 6.9 g of methionine/kg, with increments of 0.8 g/kg (Exp. 1), 4.5-8.5 g of threonine/kg, with increments of 0.8 g/kg (Exp. 2), and 1.1-2.1 g of tryptophan/kg, with increments of 0.2 g/kg (Exp. 3), respectively. The methionine requirement was conducted in the presence of 4.5 g total cysteine/kg diet which was 4.3 g/kg diet in SID cysteine. Average daily gain and gain to feed ratio showed linear and quadratic relations to increasing levels of SID methionine, threonine, and tryptophan, respectively (P < 0.01). The SID requirements for broiler chicks at the age of 1-10 days were determined using 12.4 g/kg of SID lysine concentrations in the dietary treatments. The requirement for average daily gain and gain to feed ratios were 3.85 and 3.84 g/kg for SID methionine when the diet contained 4.3 g SID cysteine/kg diet (thus, total sulfur AA requirements were 8.15 and 8.14 g/kg, respectively), 7.11 and 7.38 g/kg for SID threonine, and 1.58 and 1.36 g/kg for SID tryptophan, respectively. By using the upper limit of the broken-line requirement, the ideal SID AA to lysine ratios of 10-day-old broiler chickens were 0.31, 0.60, and 0.13 for methionine (in the presence of 4.3 SID cysteine/kg diet), threonine, and tryptophan, respectively. | Lee, Jinyoung; Sung, Youn Kyoung; Kong, Changsu | Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada; Easy Bio Inc, Seoul 06253, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea | 57201793739; 57206497419; 36027521600 | changsukong@knu.ac.kr; | ANIMAL FEED SCIENCE AND TECHNOLOGY | ANIM FEED SCI TECH | 0377-8401 | 1873-2216 | 262 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | 2020 | 3.247 | 11.9 | 0.78 | 2025-06-25 | 5 | 6 | Amino acids; Broiler; Ideal protein; Requirement; Standardized ileal digestibility | AMINO-ACID REQUIREMENT; NUTRITIONAL-REQUIREMENTS; PERIOD 3; CHICKENS; TEMPERATURE; ISOLEUCINE; ARGININE; LEVEL | Amino acids; Broiler; Ideal protein; Requirement; Standardized ileal digestibility | English | 2020 | 2020-04 | 10.1016/j.anifeedsci.2020.114427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Loss-of-function of EBP50 is a new cause of hereditary peripheral neuropathy: EBP50 functions in peripheral nerve system | Finding causative genetic mutations is important in the diagnosis and treatment of hereditary peripheral neuropathies. This study was conducted to find new genes involved in the pathophysiology of hereditary peripheral neuropathy. We identified a new mutation in the EBP50 gene, which is co-segregated with neuropathic phenotypes, including motor and sensory deficit in a family with Charcot-Marie-Tooth disease. EBP50 is known to be important for the formation of microvilli in epithelial cells, and the discovery of this gene mutation allowed us to study the function of EBP50 in the nervous system. EBP50 was strongly expressed in the nodal and paranodal regions of sciatic nerve fibers, where Schwann cell microvilli contact the axolemma, and at the growth tips of primary Schwann cells. In addition, EBP50 expression was decreased in mouse models of peripheral neuropathy. Knockout mice were used to study EBP50 function in the peripheral nervous system. Interestingly motor function deficit and abnormal histology of nerve fibers were observed in EBP50(+/-) heterozygous mice at 12 months of age, but not 3 months. in vitro studies using Schwann cells showed that NRG1-induced AKT activation and migration were significantly reduced in cells overexpressing the I325V mutant of EBP50 or cells with knocked-down EBP50 expression. In conclusion, we show for the first time that loss of function due to EBP50 gene deficiency or mutation can cause peripheral neuropathy. | Song, Gyun Jee; Gupta, Deepak Prasad; Rahman, Md Habibur; Park, Hwan Tae; Al Ghouleh, Imad; Bisello, Alessandro; Lee, Maan-Gee; Park, Jae-Yong; Park, Hyun Ho; Jun, Jin Hyun; Chung, Ki Wha; Choi, Byung-Ok; Suk, Kyoungho | Catholic Kwandong Univ, Int St Marys Hosp, Inst Biomed Convergence, Dept Med Sci, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Dept Pharmacol,Brain Sci & Engn Inst, Daegu, South Korea; Dong A Univ, Coll Med, Dept Mol Neurosci, Busan, South Korea; Univ Pittsburgh, Sch Med, Dept Med, Div Cardiol, Pittsburgh, PA 15213 USA; Univ Pittsburgh, Med Ctr, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA; Korea Univ, Coll Hlth Sci, Sch Biosyst & Biomed Sci, Seoul, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Eulji Univ, Dept Senior Healthcare, BK21 Plus Program,Coll Hlth Sci, Grad Sch Eulji Univ,Dept Biomed Lab Sci, Seongnam, South Korea; Kongju Natl Univ, Dept Biol Sci, Gongju, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea | park, hyun/D-2627-2011; Rahman, Md Habibur/HMD-4572-2023 | 7402253055; 57209821796; 59607139800; 12754817400; 36914825700; 6603843489; 7409123157; 57206479071; 7601569577; 7202753073; 8152647000; 7402755390; 7005114595 | gyunjeesong@gmail.com;bochoi77@hanmail.net;ksuk@knu.ac.kr; | GLIA | GLIA | 0894-1491 | 1098-1136 | 68 | 9 | SCIE | NEUROSCIENCES | 2020 | 7.452 | 11.9 | 0.37 | 2025-06-25 | 7 | 6 | Charcot-Marie-Tooth disease; EBP50; ezrin-radixin-moesin-binding phosphoprotein; hereditary peripheral neuropathy; mutation; Schwann cells | MARIE-TOOTH DISEASE; MYELIN SHEATH; PROTEIN; EZRIN; RADIXIN; MOESIN; NHERF-1; PHOSPHORYLATION; INTERNALIZATION; PHOSPHOPROTEIN | Charcot–Marie–Tooth disease; EBP50; ezrin–radixin–moesin-binding phosphoprotein; hereditary peripheral neuropathy; mutation; Schwann cells | Animals; Charcot-Marie-Tooth Disease; Mice; Mice, Knockout; Mutation; Peripheral Nerves; Peripheral Nervous System; ebp50 protein; neu differentiation factor; scaffold protein; unclassified drug; adult; Akt signaling; animal cell; animal experiment; animal model; animal tissue; Article; cell migration; cellular distribution; clinical feature; controlled study; gene expression; gene function; genetic disorder; hereditary motor sensory neuropathy; human; loss of function mutation; major clinical study; male; microvillus; middle aged; missense mutation; motor performance; mouse; nerve cell growth; nerve fiber; nerve fiber membrane; nonhuman; pathogenesis; peripheral nervous system; peripheral neuropathy; phenotype; point mutation; priority journal; protein localization; Schwann cell; sciatic nerve; animal; genetics; hereditary motor sensory neuropathy; knockout mouse; mutation; peripheral nerve | English | 2020 | 2020-09 | 10.1002/glia.23805 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Model matching of input state asynchronous sequential machines with actuator saturation and bounded delays | This paper presents model matching of input/state asynchronous sequential machines (ASMs) in which the corrective controller has the restriction of actuator saturation. As this restriction gives rise to a decrease in the length of control input sequences, a tighter existence condition is needed to achieve the control goal. We also propose the delayed model matching problem in association with actuator saturation, where the stable-state behavior of the closed-loop system is made equivalent with that of a reference model within a finite delay. The delay-bound controllability condition is analyzed and the design procedure for an appropriate model matching controller is addressed in the framework of corrective control theory. An illustrative example is provided to demonstrate the proposed notions and controller synthesis. (C) 2020 Elsevier Ltd. All rights reserved. | Yang, Jung-Min; Lee, Dong-Eun | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Engn Environm & Energy, 80 Daehakro, Daegu 41566, South Korea | 57208450551; 56605563300 | jmyang@ee.knu.ac.kr;dolee@knu.ac.kr; | AUTOMATICA | AUTOMATICA | 0005-1098 | 1873-2836 | 120 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 5.944 | 11.9 | 0.29 | 2025-06-25 | 4 | 4 | Asynchronous sequential machines (ASMs); Corrective control; Model matching; Actuator saturation; Bounded delay | FAULT-TOLERANT CONTROL; SYSTEMS | Actuator saturation; Asynchronous sequential machines (ASMs); Bounded delay; Corrective control; Model matching | Actuators; Closed loop systems; Controllability; Controllers; Sequential machines; Actuator saturations; Appropriate models; Asynchronous sequential machines; Controllability condition; Controller synthesis; Corrective control; Existence conditions; Reference modeling; Electric machine theory | English | 2020 | 2020-10 | 10.1016/j.automatica.2020.109134 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat | Proprioceptive signals from body muscles have historically been considered to project to the rostrodorsal shell of the ventrobasal thalamic complex [the ventral posterolateral nucleus (VPL) and ventral posteromedial nucleus (VPM)]. However, we have recently found that proprioception from rat jaw-closing muscle spindles (JCMSs) is conveyed via the supratrigeminal nucleus to the caudo-ventromedial edge of the VPM, but not to the rostrodorsal shell of the VPM. Therefore, proprioception from other body muscles may also project to thalamic regions other than the rostrodorsal shell of the VPL. We thus examined the thalamic projection from the rat external cuneate nucleus (ECu), which receives proprioceptive inputs from forelimb and neck muscles. After injection of anterograde tracer into the ECu, axon terminals were contralaterally labeled in the ventromedial part (VPLvm) of the VPL, but not in the rostrodorsal shell of the VPL. After anterograde tracer injection into the cuneate nucleus (Cu), axon terminals were widely labeled in the contralateral VPL including the VPLvm. In the VPLvm, we electrophysiologically confirmed the proprioceptive inputs responsive to electrical stimulation of the ECu or median nerve and to the pressure of forelimb/neck muscles or wrist flexion. After retrograde tracer injection into the VPLvm, neurons were contralaterally labeled in the ECu and Cu. After retrograde tracer injection into the VPL where no such proprioceptive inputs were recorded, no ECu neurons were labeled. These findings indicate that proprioception from forelimb/neck muscle spindles and JCMSs is somatotopically transmitted to the ventromedial floor of the ventrobasal thalamic complex, but not to its rostrodorsal shell. | Uemura, Yume; Haque, Tahsinul; Sato, Fumihiko; Tsutsumi, Yumi; Ohara, Haruka; Oka, Ayaka; Furuta, Takahiro; Bae, Yong Chul; Yamashiro, Takashi; Tachibana, Yoshihisa; Yoshida, Atsushi | Osaka Univ, Dept Oral Anat & Neurobiol, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan; Osaka Univ, Grad Sch Dent, Dept Orthodont & Dentofacial Orthoped, Suita, Osaka 5650871, Japan; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 700412, South Korea; Kobe Univ, Div Syst Neurosci, Grad Sch Med, Chuo Ku, 7-5-1 Kusunoki, Kobe, Hyogo 6500017, Japan; King Saud Univ, Coll Dent, Dept Oral Med & Diagnost Sci, Riyadh 11545, Saudi Arabia | ; Yamashiro, Takashi/S-6010-2019; Haque, Tahsinul/KUC-7054-2024; Haque, Md/KUC-7054-2024 | 57196148796; 26537402900; 37112998700; 57196150893; 55894067000; 36114737500; 7201372674; 56377838800; 55416765600; 47461520500; 55757780066 | yoshi@med.kobe-u.ac.jp;yoshida@dent.osaka-u.ac.jp; | BRAIN STRUCTURE & FUNCTION | BRAIN STRUCT FUNCT | 1863-2653 | 1863-2661 | 225 | 7 | SCIE | ANATOMY & MORPHOLOGY;NEUROSCIENCES | 2020 | 3.27 | 11.9 | 1 | 2025-06-25 | 14 | 14 | Deep sensation; Muscle sensation; Dorsal column nuclei; VPL | DORSAL COLUMN NUCLEI; LOW-THRESHOLD MUSCLE; I ACTIVATED CELLS; SOMATOTOPIC ORGANIZATION; CEREBRAL-CORTEX; SOMATOSENSORY CORTEX; AFFERENT-PROJECTIONS; BRAIN-STEM; NEURONS; MAIN | Deep sensation; Dorsal column nuclei; Muscle sensation; VPL | Animals; Electric Stimulation; Forelimb; Male; Medulla Oblongata; Muscle Spindles; Neck Muscles; Neural Pathways; Neurons; Proprioception; Rats; Rats, Wistar; Thalamus; biotinylated dextranamine; cholera toxin B subunit; fluorogold; tracer; unclassified drug; animal cell; animal tissue; Article; axon; cuneate nucleus; electrophysiological procedures; electrophysiology; electrostimulation; evoked response; forelimb; male; median nerve; muscle spindle; neck muscle; nerve cell; nerve ending; nonhuman; priority journal; proprioception; rat; thalamus; thalamus nucleus; thalamus ventral nucleus; wrist; animal; forelimb; medulla oblongata; neck muscle; nerve tract; physiology; thalamus; Wistar rat | English | 2020 | 2020-09 | 10.1007/s00429-020-02118-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | 1,7-Bis(4-hydroxyphenyl)-4-hepten-3-one from Betula platyphylla induces apoptosis by suppressing autophagy flux and activating the p38 pathway in lung cancer cells | Betula platyphylla (BP) is frequently administered in the treatment of various human diseases, including cancers. This study was undertaken to investigate the pharmacological function of the active components in BP and the underlying mechanism of its chemotherapeutic effects in human lung cancer cells. We observed that BP extracts and 1,7-bis(4-hydroxyphenyl)-4-hepten-3-one (BE1), one of the components of BP, effectively decreased the cell viability of several lung cancer cell lines. BE1-treated cells exhibited apoptosis induction and cell cycle arrest at the G2/M phase. Further examination demonstrated that BE1 treatment resulted in suppression of autophagy, as evidenced by increased protein expression levels of both LC3 II and p62/SQSTM1. Interestingly, the pharmacological induction of autophagy with rapamycin remarkably reduced the BE1-induced apoptosis, indicating that apoptosis induced by BE1 was associated with autophagy inhibition. Our data also demonstrated that BE1 exposure activated the p38 pathway resulting in regulation of the pro-apoptotic activity. Taken together, we believe that BE1 is a potential anticancer agent for human lung cancer, which exerts its effect by enhancing apoptosis via regulating autophagy and the p38 pathway. | Jung, Hyun Jin; Song, Kyung-Sik; Son, Youn Kyoung; Seong, Je Kyung; Kim, Sun Yeou; Oh, Seung Hyun | Seoul Natl Univ, Coll Vet Med, Korea Mouse Phenotyping Ctr, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu, South Korea; Natl Inst Biol Resources, Biol & Genet Resources Assessment Div, Incheon, South Korea; Gachon Univ, Coll Pharm, 191 Hambangmoe Ro, Incheon 21936, South Korea | ; Oh, Seung/AAN-6744-2021 | 57207380797; 13310139000; 8903186200; 7004962796; 57183261700; 57207182566 | eyeball@gachon.ac.kr; | PHYTOTHERAPY RESEARCH | PHYTOTHER RES | 0951-418X | 1099-1573 | 34 | 1 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 5.882 | 12.1 | 0.7 | 2025-06-25 | 11 | 10 | 1; 7-Bis(4-hydroxyphenyl)-4-hepten-3-one; apoptosis; autophagy; Betula platyphylla; p38 | DIARYLHEPTANOIDS; CISPLATIN; INDUCTION; STRESS; ARREST; BARK | 1,7-Bis(4-hydroxyphenyl)-4-hepten-3-one; apoptosis; autophagy; Betula platyphylla; p38 | Apoptosis; Autophagy; Betula; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Transfection; 1,7 bis(4 hydroxyphenyl) 4 hepten 3 one; antineoplastic agent; Betula platyphylla extract; LC3 II protein; mitogen activated protein kinase p38; peptides and proteins; plant extract; sequestosome 1; unclassified drug; antineoplastic activity; antiproliferative activity; apoptosis; Article; autophagy; Betula platyphylla; cell viability; controlled study; cytosol; cytotoxicity; enzyme activation; enzyme inhibition; fluorescence microscopy; G2 phase cell cycle checkpoint; human; human cell; MTT assay; protein expression; RNA interference; traditional medicine; autophagy; birch; cell proliferation; chemistry; genetic transfection; lung tumor; tumor cell line | English | 2020 | 2020-01 | 10.1002/ptr.6506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Beneficial effect of fursultiamine on choroidal neovascularization: A potential blockade on metabolic reprogramming in inflammatory retinal pigment epithelium | Park, Dong Ho; Kim, Juhee; Do, Ji Yeon; Kim, Mi-Jin; Yanai, Ryoji; Lee, In-Kyu; Park, Sungmi | Kyungpook Natl Univ Hosp, Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Yamaguchi Univ, Dept Ophthalmol, Grad Sch Med, Yamaguchi, Japan | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | INVEST OPHTH VIS SCI | 0146-0404 | 1552-5783 | 61 | 7 | SCIE | OPHTHALMOLOGY | 2020 | 4.799 | 12.1 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Clinical-Pathologic Characteristics and Long-term Outcomes of Left Flexure Colonic Cancer: A Retrospective Analysis of an International Multicenter Cohort | BACKGROUND: Colorectal cancer seldom presents at the splenic flexure. Small series on left flexure tumors reported a high occurrence of negative prognostic factors called into question as causes of poor prognosis. However, because of the small number of cases, no definite conclusions can be drawn. OBJECTIVE: The aim of this study was to compare clinical-pathologic characteristics and short- and long-term outcomes of left flexure tumors with other colonic locations. DESIGN: This was a retrospective analysis of consecutive patients who underwent surgery for tumors at the splenic flexure. Each tumor was paired in a 1 to 1 fashion with a right-sided and sigmoid tumor. SETTINGS: The study was conducted in 10 international centers. PATIENTS: A total of 641 patients with left flexure tumors were included in the study. MAIN OUTCOME MEASURES: Overall survival and cancer-specific survival were measured. RESULTS: Left flexure tumors presented more frequently with stenosis (30.5%; p < 0.001), with lesions infiltrating beyond the serosa (21.9%; p = 0.001) and with a high rate of mucinous histology (8.8%; p = 0.001). Looking at long-term prognosis, no differences were observed among the 3 groups, both considering overall and cancer-specific survival. However, left flexure tumors recurred more frequently as peritoneal carcinomatosis (20.6%; p < 0.001). LIMITATIONS: This study was limited because of its retrospective nature. CONCLUSIONS: Although left flexure tumors display several negative prognostic factors, they are not characterized by a worse prognosis compared with other colon cancer locations. See Video Abstract at http://links.lww.com/DCR/B395. | Pedrazzani, Corrado; Turri, Giulia; Park, Soo Yeun; Hida, Koya; Fukui, Yudai; Crippa, Jacopo; Ferrari, Giovanni; Origi, Matteo; Spolverato, Gaya; Zuin, Matteo; Bae, Sung Uk; Baek, Seong Kyu; Costanzi, Andrea; Maggioni, Dario; Son, Gyung Mo; Scala, Andrea; Rockall, Timothy; Guglielmi, Alfredo; Choi, Gyu Seog; Larson, David W. | Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Div Gen & Hepatobiliary Surg, Verona, Italy; Kyungpook Natl Univ, Med Ctr, Colorectal Canc Ctr, Sch Med, Daegu, South Korea; Kyoto Univ, Dept Surg, Grad Sch Med, Kyoto, Japan; Mayo Clin, Div Colon & Rectal Surg, Dept Surg, Rochester, MN USA; ASST Grande Osped Metropolitano Niguarda, Dept Gen Surg, Niguarda Hosp, Milan, Italy; Univ Padua, Dept Surg Oncol & Gastroenterol, Surg Clin Sect 1, Padua, Italy; Keimyung Univ, Sch Med, Dept Surg, Div Colorectal Surg, Daegu, South Korea; Dongsan Med Ctr, Daegu, South Korea; ASST Lecco, Gen Surg Unit, San Leopoldo Mandic Hosp Merate, Lecce, Italy; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Surg, Yangsan, South Korea; Royal Surrey Natl Hlth Serv Fdn Trust, Dept Colorectal & Minimal Access Surg, Guildford, Surrey, England | ; Spolverato, Gaya/M-1965-2017; Ferrari, Giovanni/AAK-1893-2020; Bae, Sung/W-1915-2019; Crippa, Jacopo/AAC-5116-2019; 손, 경모/HZJ-3181-2023; Costanzi, Andrea/AAA-2395-2021; Turri, Giulia/AAA-8971-2021 | 6602542489; 57203867916; 40561578300; 16301465700; 56581181500; 56559681900; 57217432305; 56097135900; 41862392700; 57215969229; 55748167300; 25930840200; 23024248800; 23025096100; 35741980300; 57200971399; 6701736878; 7004542428; 8058759100; 8148482100 | corrado.pedrazzani@univr.it; | DISEASES OF THE COLON & RECTUM | DIS COLON RECTUM | 0012-3706 | 1530-0358 | 63 | 12 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2020 | 4.785 | 12.1 | 0.42 | 2025-06-25 | 9 | 8 | Colon cancer; Left flexure; Prognosis; Splenic flexure; Surgical treatment | EXTENDED RIGHT COLECTOMY; SPLENIC FLEXURE; SURGICAL-TREATMENT; COLORECTAL-CANCER; CLINICOPATHOLOGICAL CHARACTERISTICS; LAPAROSCOPIC RESECTION; CLASICC TRIAL; CARCINOMA; SURVIVAL; SURGERY | Colon cancer; Left flexure; Prognosis; Splenic flexure; Surgical treatment | Aged; Colon, Transverse; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Peritoneal Neoplasms; Prognosis; Retrospective Studies; Survival Analysis; aged; cancer staging; clinical trial; colon tumor; comparative study; female; human; male; middle aged; multicenter study; pathology; peritoneum tumor; procedures; prognosis; retrospective study; surgery; survival analysis; transverse colon; tumor recurrence | English | 2020 | 2020-12 | 10.1097/dcr.0000000000001785 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Diversity, Pathogenicity, and Fungicide Sensitivity of Colletotrichum Species Associated with Apple Anthracnose in South Korea | Apple fruits with anthracnose symptoms were collected from commercial apple orchards in different regions of the Republic of Korea, and isolations were made on potato dextrose agar to isolate the causal agents. The fungal isolates were identified based on their morphological characteristics, growth rates, and multigene sequences. Nine isolates were identified via phylogenetic analysis: three Colletotrichum fructicola, two C. fioriniae, one C. gloeosporioides sensu stricto (s.s.), two C. nymphaeae, and one C. siamense isolates. The pathogenicity of the Colletotrichum isolates was tested using detached apple fruits under laboratory conditions. This study also reidentified six Colletotrichum isolates responsible for apple anthracnose, which were deposited in the Korean Agricultural Culture Collection. Among the six isolates, three were identified as C. siamense (deposited as C. gloeosporioides s.s.), and three were C. nymphaeae (deposited as C. acutatum s.s.). All the Colletotrichum species identified in this study were highly sensitive to tebuconazole in terms of inhibition of mycelial growth (EC50 value of 0.12 to 2.1 mu g/ml). | Kim, Chi Hyun; Hassan, Oliul; Chang, Taehyun | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Ecol & Environm Syst, Sangju 37224, Gyeongbuk, South Korea | Hassan, Oliul/AEB-6678-2022; Chang, Taehyun/S-1364-2019 | 57204929862; 12762464400; 55301101700 | thchang@knu.ac.kr; | PLANT DISEASE | PLANT DIS | 0191-2917 | 1943-7692 | 104 | 11 | SCIE | PLANT SCIENCES | 2020 | 4.438 | 12.1 | 1.29 | 2025-06-25 | 27 | 27 | Colletotrichum species; anthracnose; fungicide sensitivity | 1ST REPORT; BITTER ROT; MOLECULAR CHARACTERIZATION; GLOEOSPORIOIDES COMPLEX; PRIMER SETS; FRUCTICOLA; NYMPHAEAE; IDENTIFICATION; FIORINIAE; DISEASE | Anthracnose; Colletotrichum Species; Fungicide Sensitivity | Colletotrichum; Fungicides, Industrial; Malus; Phylogeny; Plant Diseases; Republic of Korea; Virulence; fungicide; Colletotrichum; genetics; Malus; phylogeny; plant disease; South Korea; virulence | English | 2020 | 2020-11 | 10.1094/pdis-01-20-0050-re | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Fingerprint matching of beyond-WIMP dark matter: neural network approach | Improving observation of galactic-scale structure provide important clues to dark matter properties. While weakly interacting massive particles (WIMPs) provide cold dark matter on galactic scales, beyond-WIMP candidates suppress the galactic-scale structure formation. Nevertheless, directly constraining microscopic model parameters from observations involves an interdisciplinary and time-consuming procedure. In practice, some parametrizations of the linear matter power spectrum are introduced. The particle physics community calculates the linear matter power spectrum for a given model parameter set, while the astrophysics community places the constraint on the power spectrum parameters. If maps between the model parameters and the power spectrum parameters and maps between the power spectrum parameters and the likelihood (or observables) are shared among the two communities, they are very useful for both communities, e.g., making a constraint plot of the model parameter space. As suggested in the literature, however, it is necessary to introduce multiple parameters to precisely describe the linear matter power spectrum in a wide range of beyond-WIMP models. It challenges us to express and share the non-linear maps between multiple parameters. In this work, we propose utilizing the neural network technique to this end. The neural network technique is known to automatically express and efficiently share non-linear maps, although it is not as simple as analytic fitting formulas if available. To demonstrate how to work with a concrete example, we consider a simplified model of light feebly interacting massive particles and simple observables for galactic-scale structure. We also reveal the obtained neural networks through the arXiv website. | Bae, Kyu Jung; Jinno, Ryusuke; Kamada, Ayuki; Yanagi, Keisuke | Inst for Basic Sci Korea, Ctr Theoret Phys Universe, Daejeon 34126, South Korea; DESY, D-22607 Hamburg, Germany; Univ Tokyo, Dept Phys, Bunkyo Ku, Tokyo 1130033, Japan; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | 56050180300; 55237781600; 55555303000; 57189843874 | kyujung.bae@knu.ac.kr;ryusuke.jinno@desy.de;akamada@ibs.re.kr;yanagi@hep-th.phys.s.u-tokyo.ac.jp; | JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS | J COSMOL ASTROPART P | 1475-7516 | 3 | SCIE | ASTRONOMY & ASTROPHYSICS;PHYSICS, PARTICLES & FIELDS | 2020 | 5.839 | 12.1 | 0.13 | 2025-06-25 | 3 | 2 | cosmology of theories beyond the SM; dark matter theory; dwarfs galaxies; Lyman alpha forest | LARGE-SCALE STRUCTURE; LYMAN-ALPHA FOREST; DWARF GALAXIES; LAMBDA-CDM; TOO BIG; HYDRODYNAMICAL SIMULATIONS; RADIATION INTERACTIONS; DENSITY-FLUCTUATIONS; STERILE NEUTRINOS; VELOCITY FUNCTION | English | 2020 | 2020-03 | 10.1088/1475-7516/2020/03/042 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | News Item | First Report of Anthracnose of Peach (Prunus persica) Caused by Colletotrichum fructicola in Korea | Lee, Dae Min; Hassan, Oliul; Kim, Chi Hyun; Chang, Taehyun | Kyungpook Natl Univ, Dept Ecol & Environm Syst, Coll Ecol & Environm Sci, Sangju 37224, Gyeongsangbuk D, South Korea | Hassan, Oliul/AEB-6678-2022; Chang, Taehyun/S-1364-2019 | 57216852407; 12762464400; 57204929862; 55301101700 | PLANT DISEASE | PLANT DIS | 0191-2917 | 1943-7692 | 104 | 5 | SCIE | PLANT SCIENCES | 2020 | 4.438 | 12.1 | 0.96 | 2025-06-25 | 6 | 6 | anthracnose; Prunus persica; Colletotrichum fructicola | English | 2020 | 2020-05 | 10.1094/pdis-08-19-1646-pdn | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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