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○ | ○ | Article | Zoonotic potential of Enterocytozoon bieneusi in pre-weaned Korean native calves | BackgroundEnterocytozoon bieneusi is the most common microsporidian species infecting humans and various animals worldwide. To date, there has been limited information on the prevalence of infection and genotypes of E. bieneusi in cattle in the Republic of Korea. Therefore, this study investigated the prevalence and genotypes of E. bieneusi circulating in pre-weaned Korean native calves and determined the age pattern of E. bieneusi infection and the relationship between E. bieneusi infection and diarrhea.MethodsThe prevalence of E. bieneusi infection in pre-weaned Korean native calves was screened by polymerase chain reaction. PCR-positive products were sequenced to determine the genotype of E. bieneusi. A Chi-square analysis was used to compare the association between diarrhea and the infection rate of E. bieneusi in each age range or for all ages.ResultsPCR and sequencing analysis revealed an overall prevalence (16.9%, 53/314) of E. bieneusi in pre-weaned calves. The prevalence of E. bieneusi was highest in September (36.2%), followed by March (28.3%). Enterocytozoon bieneusi infection was associated with diarrhea in calves (chi (2) = 5.82, P = 0.016). Our results also indicated that E. bieneusi infection was significantly associated with calf age (chi (2) = 11.61, P = 0.003), and the prevalence of E. bieneusi infection was significantly higher in calves aged 21-40 days-old (odds ratio: 2.90, 95% confidence interval: 1.54-5.45; P = 0.001) than in those aged 1-20 days-old. Interestingly, the association between E. bieneusi infection and diarrhea was observed only in calves aged 1-20 days-old (chi (2) = 5.82, P = 0.010). We identified three known genotypes, BEB4 (n = 12), BEB8 (n = 21) and J (n = 16), and three novel genotypes, BEB8-like (n = 21), KCALF1 (n = 1) and KCALF2 (n = 1). The genotype BEB8 was the most prevalent among all age groups. All genotypes identified in this study exhibited zoonotic potential.ConclusionsTo our knowledge, this is the first report of the genotype BEB4 in pre-weaned Korean native calves. Zoonotic E. bieneusi infection was prevalent in pre-weaned calves, indicating that cattle may play an important role as a reservoir host for E. bieneusi transmission to humans. | Hwang, Sunwoo; Shin, Seung-Uk; Kim, SuHee; Ryu, Ji-Hyoung; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Gyeongsang Natl Univ Hosp, Jinju 52727, South Korea; Anim & Plant Quarantine Agcy, Foreign Anim Dis Div, Gimcheon 39660, South Korea | 57217125669; 56967385500; 36614279700; 57201116268; 7403949556; 58950742600 | kschoi3@knu.ac.kr; | PARASITES & VECTORS | PARASITE VECTOR | 1756-3305 | 13 | 1 | SCIE | PARASITOLOGY;TROPICAL MEDICINE | 2020 | 3.876 | 10.9 | 1.49 | 2025-06-25 | 14 | 15 | Enterocytozoon bieneusi; Pre-weaned Korean native calf; Genotype; Zoonotic infection | DAIRY-CATTLE; MOLECULAR CHARACTERIZATION; GIARDIA-DUODENALIS; MICROSPORIDIOSIS; INFECTION; GENOTYPES; CRYPTOSPORIDIUM; NORTHEAST; SEQUENCE; CHINA | Enterocytozoon bieneusi; Genotype; Pre-weaned Korean native calf; Zoonotic infection | Age Factors; Animals; Cattle; Diarrhea; Disease Reservoirs; Enterocytozoon; Farms; Genotype; Humans; Microsporidiosis; Prevalence; Republic of Korea; Weaning; Zoonoses; age; Article; calf (bovine); diarrhea; disease association; Enterocytozoon bieneusi; Enterocytozoon infection; fungus transmission; genotype; infection rate; Korea; nonhuman; odds ratio; polymerase chain reaction; prevalence; sequence analysis; zoonosis; agricultural land; animal; bovine; disease carrier; Enterocytozoon; genetics; human; microbiology; microsporidiosis; South Korea; veterinary medicine; weaning; zoonosis | English | 2020 | 2020-06-10 | 10.1186/s13071-020-04175-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Crepuscular Rays from the Highly Inclined Active Galactic Nucleus in IC 5063* | On Earth near sunset, the Sun may cast "crepuscular rays" such that clouds near the horizon obscure the origin of light scattered in bright rays. In principle, active galactic nuclei (AGN) should be able to produce similar effects. Using new Hubble Space Telescope (HST) near-infrared and optical observations, we show that the active galaxy IC 5063 contains broad radial rays extending to greater than or similar to 11 kpc from the nucleus. We argue that the bright rays may arise from dusty scattering of continuum emission from the active nucleus, while the dark rays are due to shadowing near the nucleus, possibly by a warped torus. We also consider alternative AGN-related and stellar origins for the extended light. | Maksym, W. Peter; Schmidt, Judy; Keel, William C.; Fabbiano, Giuseppina; Fischer, Travis C.; Bland-Hawthorn, Joss; Barth, Aaron J.; Elvis, Martin; Oosterloo, Tom; Ho, Luis C.; Kim, Minjin; Hwang, Hyunmo; Mayer, Evan | Harvard & Smithsonian, Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA; Univ Maryland, Astrophys Source Code Lib, 4254 Stadium Dr, College Pk, MD 20742 USA; Univ Alabama, Dept Phys & Astron, Box 870324, Tuscaloosa, AL 35487 USA; Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA; Univ Sydney, Sch Phys, Sydney Inst Astron, Sydney, NSW, Australia; ARC Ctr Excellence All Sky Astrophys 3D, Perth, WA, Australia; Univ Calif Irvine, Dept Phys & Astron, 4129 Frederick Reines Hall, Irvine, CA 92697 USA; Netherlands Inst Radio Astron, ASTRON, Postbus 2, NL-7990 AA Dwingeloo, Netherlands; Univ Groningen, Kapteyn Astron Inst, Postbus 800, NL-9700 AV Groningen, Netherlands; Peking Univ, Kavli Inst Astron & Astrophys, Beijing 100871, Peoples R China; Peking Univ, Sch Phys, Dept Astron, Beijing 100871, Peoples R China; Kyungpook Natl Univ, Coll Nat Sci, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | ; Bland-Hawthorn, Joss/ABE-7646-2020; Oosterloo, Tom/GVU-4543-2022; Kim, Minjin/AAU-9910-2020 | 36615411900; 57190494883; 7005237646; 7005599650; 55414625800; 56253801100; 36088948300; 7006076869; 7003594300; 35229428100; 56898213300; 57219487345; 57219488206 | walter.maksym@cfa.harvard.edu; | ASTROPHYSICAL JOURNAL LETTERS | ASTROPHYS J LETT | 2041-8205 | 2041-8213 | 902 | 1 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 7.413 | 11.0 | 0.07 | 2025-06-25 | 8 | 3 | AGN host galaxies; Interstellar dust; Interstellar scattering; Galaxy mergers; Galaxy winds; Galaxy classification systems | FILAMENT FORMATION; ELLIPTIC GALAXIES; EMISSION; CLOUDS; RADIO | English | 2020 | 2020-10 | 10.3847/2041-8213/abb9b6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production | Evidence has mounted that insulin can be synthesized in various brain regions, including the hypothalamus. However, the distribution and functions of insulin-expressing cells in the hypothalamus remain elusive. Herein, we show that in the mouse hypothalamus, the perikarya of insulin-positive neurons are located in the paraventricular nucleus (PVN) and their axons project to the median eminence; these findings define parvocellular neurosecretory PVN insulin neurons. Contrary to corticotropin-releasing hormone expression, insulin expression in the PVN was inhibited by restraint stress (RS) in both adult and young mice. Acute RS-induced inhibition of PVN insulin expression in adult mice decreased both pituitary growth hormone (Gh) mRNA level and serum GH concentration, which were attenuated by overexpression of PVN insulin. Notably, PVN insulin knockdown or chronic RS in young mice hindered normal growth via the downregulation of GH gene expression and secretion, whereas PVN insulin overexpression in young mice prevented chronic RS-induced growth retardation by elevating GH production. Our results suggest that in both normal and stressful conditions, insulin synthesized in the parvocellular PVN neurons plays an important role in the regulation of pituitary GH production and body length, unveiling a physiological function of brain-derived insulin. | Lee, Jaemeun; Kim, Kyungchan; Cho, Jae Hyun; Bae, Jin Young; O'Leary, Timothy P.; Johnson, James D.; Bae, Yong Chul; Kim, Eun-Kyoung | Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, 333 Techno Jungang Daero, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Anat & Neurobiol, Daegu, South Korea; Univ British Columbia, Inst Life Sci, Dept Cellular & Physiol Sci, Diabet Res Grp,Fac Med, Vancouver, BC, Canada; Daegu Gyeongbuk Inst Sci & Technol, Neurometabol Res Ctr, Daegu, South Korea | ; Johnson, James/B-3919-2008; Lee, C./AAC-1663-2019 | 56497377600; 57188967897; 57191845644; 55268279500; 57188657716; 14121618900; 56377838800; 35073782800 | ekkim@dgist.ac.kr; | JCI INSIGHT | JCI INSIGHT | 2379-3708 | 5 | 16 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 8.315 | 11.1 | 1.03 | 2025-06-25 | 23 | 23 | CORTICOTROPIN-RELEASING HORMONE; MEDIAN-EMINENCE; MESSENGER-RNA; GENE-EXPRESSION; STRESS-RESPONSE; GH RESPONSE; RAT; SECRETION; BRAIN; NEURONS | Animals; Corticotropin-Releasing Hormone; Gene Expression Regulation; Growth Hormone; Insulin; Male; Median Eminence; Mice, Inbred C57BL; Mice, Knockout; Neurons; Paraventricular Hypothalamic Nucleus; Somatostatin; Stress, Physiological; corticotropin releasing factor; growth hormone; insulin; messenger RNA; corticotropin releasing factor; growth hormone; Ins2 protein, mouse; insulin; somatostatin; adult; animal cell; animal experiment; animal tissue; Article; axon; body height; brain nerve cell; controlled study; down regulation; gene expression; growth hormone blood level; growth retardation; hormone release; hormone synthesis; hypothalamic paraventricular nucleus; immobilization stress; infant; insulin synthesis; male; mouse; neurosecretory cell; newborn; nonhuman; perikaryon; protein expression; young adult; animal; biosynthesis; C57BL mouse; gene expression regulation; genetics; hypothalamic paraventricular nucleus; knockout mouse; median eminence; metabolism; nerve cell; physiological stress | English | 2020 | 2020-08-20 | 10.1172/jci.insight.135412 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
○ | ○ | Article | The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L | Mitophagy is a degradative pathway that mediates the degradation of the entire mitochondria, and defects in this process are implicated in many diseases including cancer. In mammals, mitophagy is mediated by BNIP3L (also known as NIX) that is a dual regulator of mitochondrial turnover and programmed cell death pathways. Acute myeloid leukemia (AML) cells with deficiency of BNIP3L are more sensitive to mitochondria-targeting drugs. But small molecular inhibitors for BNIP3L are currently not available. Some immunomodulatory drugs (IMiDs) have been proved by FDA for hematologic malignancies, however, the underlining molecular mechanisms are still elusive, which hindered the applications of BNIP3L inhibition for AML treatment. In this study we carried out MS-based quantitative proteomics analysis to identify the potential neosubstrates of a novel thalidomide derivative CC-885 in A549 cells. In total, we quantified 5029 proteins with 36 downregulated in CRBN+/+ cell after CC-885 administration. Bioinformatic analysis showed that macromitophagy pathway was enriched in the negative pathway after CC-885 treatment. We further found that CC-885 caused both dose- and time-dependent degradation of BNIP3L in CRBN+/+, but not CRBN-/- cell. Thus, our data uncover a novel role of CC-885 in the regulation of mitophagy by targeting BNIP3L for CRL4CRBN E3 ligase-dependent ubiquitination and degradation, suggesting that CC-885 could be used as a selective BNIP3L degradator for the further investigation. Furthermore, we demonstrated that CC-885 could enhance AML cell sensitivity to the mitochondria-targeting drug rotenone, suggesting that combining CC-885 and mitochondria-targeting drugs may be a therapeutic strategy for AML patients. | Hao, Bing-bing; Li, Xiao-jing; Jia, Xing-long; Wang, Yu-xing; Zhai, Lin-hui; Li, Duan-zhuo; Liu, Jie; Zhang, Die; Chen, Yu-lu; Xu, Yong-hu; Lee, Sang-kyu; Xu, Guo-feng; Chen, Xiao-hua; Dang, Yong-jun; Liu, Bin; Tan, Min-jia | Chinese Acad Sci, Shanghai Inst Mat Med, Chem Prote Ctr, Shanghai 201203, Peoples R China; Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; Univ Chinese Acad Sci, Beijing 100049, Peoples R China; Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Key Lab Metab & Mol Med,Minist Educ, Shanghai 200030, Peoples R China; Shanghai Univ, Sch Life Sci, Lab Noncoding RNA & Canc, Shanghai 200444, Peoples R China; Hubei Polytech Univ, Sch Med, Hubei Key Lab Kidney Dis Pathogenesis & Intervent, Huangshi 435003, Hubei, Peoples R China; Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Pediat Urol, 1665 Kongjiang St, Shanghai 200092, Peoples R China; Kyungpook Natl Univ, Coll Pharm, Plus KNU Multiom Based Creat Drug Res Team, BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Key Lab Receptor Res, Shanghai 201203, Peoples R China | Tan, Minjia/C-4491-2014; dang, yongjun/M-6531-2016; liu, Bin/AAP-1252-2020; Xu, Guofeng/I-3063-2016 | 57204628192; 57190879847; 57211355009; 57196951950; 52365505700; 57194266105; 57192066593; 57204308651; 57204333483; 57212593882; 57209046767; 55586638800; 57219379924; 57226041242; 56161089600; 36027735400 | liubin3575630@163.com;mjtan@simm.ac.cn; | ACTA PHARMACOLOGICA SINICA | ACTA PHARMACOL SIN | 1671-4083 | 1745-7254 | 41 | 9 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2020 | 6.15 | 11.1 | 1.88 | 2025-06-25 | 37 | 33 | immunomodulatory drugs (IMiDs); CC-885; BNIP3L; mitophagy; CRBN; acute myeloid leukemia; mitochondria-targeting drugs | LENALIDOMIDE; EXPRESSION; PROMOTES; STRATEGY | acute myeloid leukemia; BNIP3L; CC-885; CRBN; immunomodulatory drugs (IMiDs); mitochondria-targeting drugs; mitophagy | Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Drug Synergism; HEK293 Cells; Humans; Membrane Proteins; Mitophagy; Phenylurea Compounds; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins; Rotenone; Thalidomide; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitination; antineoplastic agent; BNIP3L protein; carbonyl cyanide chlorophenylhydrazone; cc 885; protein; rotenone; thalidomide derivative; unclassified drug; BNIP3L protein, human; carbanilamide derivative; CC-885; CRBN protein, human; membrane protein; oncoprotein; proteasome; rotenone; signal transducing adaptor protein; thalidomide; tumor suppressor protein; ubiquitin protein ligase; A-549 cell line; antineoplastic activity; Article; bioinformatics; controlled study; down regulation; drug screening; drug sensitivity; drug targeting; embryo; female; human; human cell; liquid chromatography-mass spectrometry; malignant neoplasm; mitophagy; protein analysis; protein degradation; proteomics; quantitative analysis; ubiquitination; drug effect; drug potentiation; HEK293 cell line; metabolism; mitophagy; protein degradation; tumor cell line | English | 2020 | 2020-09 | 10.1038/s41401-020-0367-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | A Novel Single-Phase Three-Level Dual-Buck Inverter | This article proposes a new single-phase three-level dual-buck inverter. The topology is derived from a simplified neutral-point clamped inverter that includes fewer active switches. The advantages of the proposed inverter are no shoot-through worries and no reverse recovery issue of the body diode of the power metal-oxide-semiconductor field-effect transistor compared with the conventional inverter; therefore, a high-reliability inverter can be achieved. The operation modes and pulsewidth modulation technique are analyzed in detail. Additionally, a switching scheme is proposed to balance and reduce the direct-current-link capacitance. A 1.4-kW prototype was built and tested to validate the theoretical analysis of the proposed converter. | Lien-The Nguyen; Cha, Honnyong; Bang Le-Huy Nguyen; Kim, Heung-Geun | Kyungpook Natl Univ, Sch Energy Engn, Daegu 1370, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 1370, South Korea | Nguyen, Tien/ABX-3214-2022; Nguyen, Bang/U-6579-2019 | 59454647000; 24450248400; 57211273880; 7410122126 | nguyenthetien93@gmail.com;chahonny@knu.ac.kr;bang.lh.nguyen@gmail.com;hgkim@lam.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 4 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 0.59 | 2025-06-25 | 9 | 11 | Inverters; Capacitors; Switches; Semiconductor diodes; Inductors; MOSFET; Modulation | AC-AC CONVERTERS; MULTILEVEL INVERTER; HIGH-RELIABILITY; NEUTRAL POINT; INDUCTOR | Metal recovery; Metals; MOS devices; Oxide semiconductors; Power MOSFET; Active switches; Conventional inverters; Direct current links; Dual Buck inverters; High reliability; Neutral point clamped inverters; Reverse recovery; Switching scheme; Electric inverters | English | 2020 | 2020-04 | 10.1109/tpel.2019.2932890 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | A Snubberless Solid-State Tap Changer for Permanent Magnet Synchronous Motors | A stator winding tap changer has been studied for a permanent magnet synchronous motor (PMSM) drive for speeds exceeding the base speed range. At low speeds, all stator windings are configured to fulfill the high output torque; at high speeds, a portion of the stator windings are configured to relieve the burden of the stator winding turns, i.e., large inductive impedance, back electromotive force (BEMF), and field-weakening current. The conventional solid-state tap changers for the PMSMs require snubber capacitors and bleeder resistors. The snubber capacitor is necessary for providing an inductor current path during the stator winding tap-change period. However, it induces long transition times and energy losses. In this article, a snubberless solid-state tap changer is proposed for PMSMs. The proposed mechanism is composed of only three-switches for each tap and controls the leakage inductance current by employing an appropriate switching sequence. With the proposed tap changer, the transition period is reduced and energy loss by bleeder resistance is eliminated. The results of a simulation and an experiment are used to validate the proposed scheme. | Im, Seong-Hwan; Gu, Bon-Gwan | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | 57212462415; 50061273700 | imsh9698@naver.com;bggu@knu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 11 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 3.5 | 2025-06-25 | 12 | 17 | Windings; Stator windings; Switches; Permanent magnet motors; Snubbers; Inductance; High-speed drive; switchable winding turns; tap changer; winding changeover | SCHEME | High-speed drive; switchable winding turns; tap changer; winding changeover | Energy dissipation; Stators; Synchronous motors; Winding; Back electromotive force; Inductor currents; Leakage inductance; Permanent Magnet Synchronous Motor; Permanent magnet synchronous motor drives; Snubber capacitors; Switching sequence; Transition period; Permanent magnets | English | 2020 | 2020-11 | 10.1109/tpel.2020.2988933 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Automatic segmentation of mitochondria and endolysosomes in volumetric electron microscopy data | Automatic segmentation of intracellular compartments is a powerful technique, which provides quantitative data about presence, spatial distribution, structure and consequently the function of cells. With the recent development of high throughput volumetric data acquisition techniques in electron microscopy (EM), manual segmentation is becoming a major bottleneck of the process. To aid the cell research, we propose a technique for automatic segmentation of mitochondria and endolysosomes obtained from urinary bladder urothelial cells by the dual beam EM technique. We present a novel publicly available volumetric EM dataset - the first of urothelial cells, evaluate several state-of-the-art segmentation methods on the new dataset and present a novel segmentation pipeline, which is based on supervised deep learning and includes mechanisms that reduce the impact of dependencies in the input data, artefacts and annotation errors. We show that our approach outperforms the compared methods on the proposed dataset. | Mekuc, Manca Zerovnik; Bohak, Ciril; Hudoklin, Samo; Kim, Byeong Hak; Romih, Rok; Kim, Min Young; Marolt, Matija | Univ Ljubljana, Fac Comp & Informat Sci, Vecna Pot 113, Ljubljana 1000, Slovenia; Univ Ljubljana, Fac Med, Inst Cell Biol, Vrazov Trg 2, Ljubljana 1000, Slovenia; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Ctr Neurosurg Robot Syst, Daegu 41566, South Korea; Hanwha Syst Corp, Optron Team, 1gongdan Ro, Gumi 39376, South Korea | 57215543576; 55582372100; 15730731600; 56406686400; 6602144223; 56739349100; 6603601816 | manca.zerovnik-mekuc@fri.uni-lj.si;ciril.bohak@fri.uni-lj.si;samo.hudoklin@mf.uni-lj.si;byeonghak81.kim@hanwha.com;rok.romih@mf.uni-lj.si;minykim@knu.ac.kr;matija.marolt@fri.uni-lj.si; | COMPUTERS IN BIOLOGY AND MEDICINE | COMPUT BIOL MED | 0010-4825 | 1879-0534 | 119 | SCIE | BIOLOGY;COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;MATHEMATICAL & COMPUTATIONAL BIOLOGY | 2020 | 4.589 | 11.2 | 1.42 | 2025-06-25 | 33 | 40 | Intracellular compartments; Segmentation; Volumetric electron microscopy data; Mitochondria; Endosomes; Lysosomes; Endolysosomes; Urothelium; Deep learning | 3D; UROTHELIUM | Deep learning; Endolysosomes; Endosomes; Intracellular compartments; Lysosomes; Mitochondria; Segmentation; Urothelium; Volumetric electron microscopy data | Cytology; Data acquisition; Electron microscopes; Electron microscopy; Image segmentation; Mitochondria; Volumetric analysis; Endolysosomes; Endosomes; Intracellular compartments; Lysosomes; Urothelium; Volumetric electron microscopy data; article; artifact; deep learning; electron microscopy; endosome; human cell; lysosome; mitochondrion; pipeline; urothelium; Deep learning | English | 2020 | 2020-04 | 10.1016/j.compbiomed.2020.103693 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Coupled-Inductor Buck-Boost Inverter With Reduced Current Ripple | This article presents novel buck-boost inverter using coupled inductors and half-cycle phase-shifted modulation. The effective switching frequency of the input inductors is twice the actual switching frequency of semiconductor switches. In addition, the number of voltage levels of the input inductors is increased and the voltage magnitude is decreased. As a result, the input inductors are designed much smaller and the current ripples of both the input inductors and the dc voltage source are decreased. To reduce the number of inductors, input inductors are incorporated in the leakage inductance of the coupled inductors. Moreover, part of the circuit can be bypassed to improve the efficiency of the proposed inverter. The clamping switches decrease the power loss of circulating current and improve the peak efficiency to 97.2%. Besides, the proposed inverter has no shoot-through. Furthermore, mosfets can be used without reverse-recovery issues and associated loss. As a proof of concept, the experimental results of the proposed single-phase 500-W prototype inverter with 100-200 V input voltage and 110 Vrms output voltage at 50 kHz are provided. | Khan, Ashraf Ali; Eberle, Wilson; Wang, Liwei; Akbar, Fazal; Khan, Usman Ali; Lu, Yun W.; Agamy, Mohammad | Univ British Columbia, Sch Engn, Okanagan, BC V1V 1V7, Canada; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Yonsei Univ, Dept Elect & Elect Engn, Seoul 03722, South Korea; SUNY Albany, Dept Elect & Comp Engn, Albany, NY 12222 USA | ; akbar, fazal/AAU-7197-2020; Khan, Ashraf/IXW-6751-2023 | 56341377400; 7003503379; 57092318000; 57194409251; 57206383294; 57211499760; 6508315042 | khan.ashraf@ubc.ca;wilson.eberle@ubc.ca;liwei.wang@ubc.ca;fazalakbar923@gmail.com;usman_705@ymail.com;waynelu.lu@gmail.com;magamy@albany.edu; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 8 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 0.97 | 2025-06-25 | 18 | 21 | Inductors; Inverters; Switching frequency; Clamps; Switches; Inductance; MOSFET; Boost inverter; coupled inductor; effective switching frequency; efficiency; input inductor; pulsewidth modulation (PWM) voltage levels; reliability | FREQUENCY CURRENT RIPPLE; ENERGY-STORAGE SYSTEM; HIGH-RELIABILITY; CONVERTER; DESIGN | Boost inverter; coupled inductor; effective switching frequency; efficiency; input inductor; pulsewidth modulation (PWM) voltage levels; reliability | Efficiency; Electric inverters; Switching frequency; Buck boost inverter; Circulating current; Coupled inductor; DC voltage sources; Leakage inductance; Proof of concept; Reverse recovery; Voltage magnitude; Electric inductors | English | 2020 | 2020-08 | 10.1109/tpel.2019.2962668 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Reactive Power Elimination for High Conversion-Ratio Bidirectional Resonant Converter | This article presents a reactive power elimination method for high conversion-ratio bidirectional resonant converter with ripple-free current at the low voltage side. When transferring power in the backward mode operation, the converter with heavy loads suffers from significant reverse current that generates reactive power. By adjusting the right amount of phase of the pulsewidth modulation signals, we can eliminate the reverse current and the corresponding reactive power. We derive the voltage gain, calculate the right amount of phase, and identify the load threshold, above which the reverse current appears. We use a 600W converter prototype to demonstrate the performance of the proposed converter. | Seok, Hwasoo; Junyent-Ferre, Adria; Cha, Honnyong; Kim, Minsung | Pohang Univ Sci & Technol POSTECH, Dept Creat IT Engn, Pohang 37673, South Korea; Imperial Coll London, Dept Elect & Elect Engn, South Kensington Campus, London SW7 2BT, England; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Dongguk Univ, Div Elect & Elect Engn, Seoul 04620, South Korea | 57194412580; 24767805700; 24450248400; 57201445330 | aeinla@postech.ac.kr;adria.junyent-ferre@imperial.ac.uk;chahonny@knu.ac.kr;mkim@dongguk.edu; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 4 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 0.37 | 2025-06-25 | 7 | 7 | Pulse width modulation; RLC circuits; Switches; Zero voltage switching; Inductors; Capacitors; Reactive power; Bidirectional operation; high step-up; down; modulation technique; phase shift; reverse current; reactive power; zero current ripple | DC-DC CONVERTER; RIPPLE | Bidirectional operation; high step-up/down; modulation technique; phase shift; reactive power; reverse current; zero current ripple | Modulation; Phase shift; Reactive power; Bidirectional operation; High step-ups; Modulation techniques; Reverse currents; Zero currents; Power converters | English | 2020 | 2020-04 | 10.1109/tpel.2019.2937109 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Single-Phase Split-Inductor Differential Boost Inverters | In this paper, two single-phase single-stage split-inductor buck-boost inverters are proposed: type-I and II. The proposed type-I is unity power factor inverter, while the proposed type-II inverter is suitable for any power factor. Both topologies remove the shoot-through problem. Furthermore, the reverse recovery issues for all switches are eliminated; therefore, MOSFETs are used to obtain higher efficiencies. The proposed inverters operated at higher switching frequencies confer the additional benefit of smaller passive components. The current stresses of the two switches in the proposed type-I and II inverters are lower of the conventional boost inverter. The dead time can be eliminated at both the high and line switching frequencies. In addition, the inductor conduction loss is minimized to improve efficiency. Moreover, the voltage stresses of the two switches in the type-I inverter can be much lower of its counterpart boost inverter. Most importantly, unlike the conventional high-reliability inverters, the magnetic volume of the proposed high-reliability type-I and II inverters is same of its counterpart boost inverter. The experimental results obtained for 500 W, 110 Vrms, 60 Hz hardware prototypes verify the analysis. | Khan, Ashraf Ali; Lu, Yun Wi; Eberle, Wilson; Wang, Liwei; Khan, Usman Ali; Cha, Honnyong | Univ British Columbia, Sch Engn, Kelowna, BC V1V 1V7, Canada; Yonsei Univ, Dept Elect & Elect Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | ; Khan, Ashraf/IXW-6751-2023 | 56341377400; 57211499760; 7003503379; 57092318000; 57206383294; 24450248400 | khan.ashraf@ubc.ca;waynelu.lu@gmail.com;wilson.eberle@ubc.ca;liwei.wang@ubc.ca;usman_705@ymail.com;Honnyong.cha@knu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 1 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 1.86 | 2025-06-25 | 25 | 32 | Buck-boost inverter; efficiency; lowcurrent stress; low-voltage stress; magnetic volume; reliability; single stage; split inductor | AC-AC CONVERTERS; DUAL-BUCK INVERTER; TRANSFORMERLESS INVERTER; HIGH-RELIABILITY; POWER LOSS | Buck-boost inverter; efficiency; low current stress; low-voltage stress; magnetic volume; reliability; single stage; split inductor | Efficiency; Electric inductors; Electric power factor; Reliability; Buck boost inverter; Low currents; Low voltages; Magnetic volume; Single stage; split inductor; Electric inverters | English | 2020 | 2020-01 | 10.1109/tpel.2019.2913750 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Single-Stage Bidirectional Buck-Boost Inverters Using a Single Inductor and Eliminating the Common-Mode Leakage Current | This paper presents novel single-phase single-stage buck-boost inverters. The proposed inverters provide buck-boost operation for a wide variation of the input dc voltage. In addition, the proposed inverters are bidirectional and provide reactive power. Further, they require only one inductor. The proposed inverters also eliminate the common-mode leakage current by connecting the output neutral to the midpoint of input capacitors or directly to input voltage sources. Therefore, they are well suitable for photovoltaic applications. Although six switches are required, two switches are working at line frequency, resulting in negligible switching loss. Of the four remaining switches, only two are switching at high frequency at a time. The circuit operations are demonstrated through the analysis of the proposed inverters. A 120 Vrms/60 Hz/400 W hardware prototype was constructed and tested. The experimental results verified the theoretical analysis. | Khan, Ashraf Ali; Lu, Yun W.; Eberle, Wilson; Wang, Liwei; Khan, Usman Ali; Agamy, Mohammad; Cha, Honnyong | Univ British Columbia, Sch Engn, Okanagan, BC V1V 1V7, Canada; Yonsei Univ, Dept Elect & Elect Engn, Seoul 03722, South Korea; SUNY Albany, Dept Elect & Comp Engn, Albany, NY 12222 USA; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | ; Khan, Ashraf/IXW-6751-2023 | 56341377400; 57211499760; 7003503379; 57092318000; 57206383294; 6508315042; 24450248400 | khan.ashraf@ubc.ca;waynelu.lu@gmail.com;wilson.eberle@ubc.ca;liwei.wang@ubc.ca;usman_705@ymail.com;magamy@albany.edu;Honnyong.Cha@knu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 35 | 2 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2020 | 6.153 | 11.2 | 1.93 | 2025-06-25 | 33 | 44 | Bidirectional; buck-boost inverter; common-mode; leakage current (CMLC); single inductor; single stage | TRANSFORMERLESS INVERTER; HIGH-RELIABILITY; CONVERTER; DESIGN | Bidirectional; buck-boost inverter; common-mode leakage current (CMLC); single inductor; single stage | Electric inductors; Leakage currents; Time switches; Bidirectional; Buck boost inverter; Common-mode leakage currents; single inductor; Single stage; Electric inverters | English | 2020 | 2020-02 | 10.1109/tpel.2019.2918349 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Effects of surface laminate type and recycled fiber content on properties of three-layer medium density fiberboard | High global production of medium-density fiberboard (MDF) in recent years could generate an equal quantity of waste MDF at the end of its service life, requiring recycling of waste MDF instead of landfilling or incineration. This study investigated effects of the addition of recycled fiber (RF) obtained from surface laminated MDFs with three different materials to the properties of three-layer recycled MDF (rMDF). Three types of surface laminates such as low-pressure laminate, polyethylene terephthalate, and polyester coating were hammer milled, and then went through a patent-pending fiber recovery system to obtain the resultant RFs that were added to the core layer of rMDF. These RFs at three contents (10, 20, and 30%) were blended with 12% of urea-formaldehyde (UF) resin prior to hot-pressing. Statistical analysis showed that the best internal bonding strength, modulus of rupture, and modulus of elasticity of rMDF panels were obtained for LPL-rMDF with a 20% RF content. Thickness swelling, water absorption, and formaldehyde emission of rMDF were reduced by increasing the RF content. These findings suggest that a minimum RF content of 20% can be replaced with virgin fibers for the rMDF manufacture, indicating the feasibility of recycling waste laminated MDF into three-layer rMDF. | Hong, Min-Kug; Lubis, Muhammad Adly Rahandi; Park, Byung-Dae; Sohn, Chang Hyun; Roh, Jeongkwan | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea; Gyungnam Natl Univ Sci & Technol, Dept Interior Mat Sci & Engn, Jinju, South Korea | Park, Byung-Dae/ABB-1934-2020; Lubis, Muhammad/K-2440-2019 | 57193121511; 57192278476; 7402834820; 36806852600; 56973409600 | byungdae@knu.ac.kr; | WOOD MATERIAL SCIENCE & ENGINEERING | WOOD MATER SCI ENG | 1748-0272 | 1748-0280 | 15 | 3 | SCIE | MATERIALS SCIENCE, PAPER & WOOD | 2020 | 2.553 | 11.4 | 1.1 | 2025-06-25 | 23 | 32 | Surface laminate materials; recycled fiber content; recycling; three-layer rMDF; panel properties | FORMALDEHYDE; MELAMINE; PARTICLEBOARD; TABLEWARE; RELEASE; RESIN | panel properties; recycled fiber content; recycling; Surface laminate materials; three-layer rMDF | Formaldehyde; Hot Pressing; Lamination; Plastic Containers; Recycling; Swelling; Formaldehyde; Hot pressing; Laminating; Plastic bottles; Recycling; Swelling; Urea; Urea formaldehyde resins; Waste incineration; Water absorption; Formaldehyde emission; Laminate materials; Medium density fiberboards; panel properties; Recycled fibers; Recycling of wastes; Thickness swelling; Three-layer; Fibers | English | 2020 | 2020-05-03 | 10.1080/17480272.2018.1528479 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Adaptive Robust Game-Theoretic Decision Making Strategy for Autonomous Vehicles in Highway | In a typical traffic scenario, autonomous vehicles are required to share the road with other road participants, e.g., human driven vehicles, pedestrians, etc. To successfully navigate the traffic, an adaptive robust level-k framework can be used by the autonomous agents to categorize the agents based on their depth of strategic thought and act accordingly. However, mismatch between the vehicle dynamics and its predictions, and improper classification of the agents can lead to undesirable behavior or collision. Robust approaches can handle the uncertainties, however, might result in a conservative behavior of the autonomous vehicle. This paper proposes an adaptive robust decision making strategy for autonomous vehicles to handle model mismatches in the prediction model while utilizing the confidence of the driver behavior to obtain less conservative actions. The effectiveness of the proposed approach is validated for a lane change maneuver in a highway driving scenario. | Sankar, Gokul S.; Han, Kyoungseok | Traxen Inc, Plymouth, MI 48170 USA; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea | 55326286700; 56465294700 | gokul.gowri@traxen.ai;kyoungsh@knu.ac.kr; | IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY | IEEE T VEH TECHNOL | 0018-9545 | 1939-9359 | 69 | 12 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS;TRANSPORTATION SCIENCE & TECHNOLOGY | 2020 | 5.978 | 11.5 | 1.97 | 2025-06-25 | 41 | 49 | Adaptive robust control; autonomous vehicles; game theory; level-k reasoning | MODEL-PREDICTIVE CONTROL; CONTROLLER | Adaptive robust control; autonomous vehicles; game theory; level-k reasoning | Autonomous agents; Behavioral research; Decision making; Game theory; Predictive analytics; Road vehicles; Roads and streets; Decision-making strategies; Driver behavior; Game-theoretic; Lane change maneuvers; Prediction model; Robust approaches; Robust decisions; Vehicle dynamics; Autonomous vehicles | English | 2020 | 2020-12 | 10.1109/tvt.2020.3041152 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | CO2 adsorption at low pressure over polymers-loaded mesoporous metal organic framework PCN-777: effect of basic site and porosity on adsorption | Selective capture of CO2 from offgas is highly important for our sustainability, including mitigating global warming. Here, we investigated the CO2 and N-2 adsorption under low pressure by using a mesoporous Zr-based metal organic framework PCN-777 with or without modification with polymers like polyethyleneimine (PEI) and polystyrene (PS). The polymers were applied in this study in order to reduce the pore size of PCN-777 (P777) and to introduce basic sites when PEI was used. PCN-777 s loaded with both the PEI and PS were effective in CO2 adsorption because of reduced pore size; and PEI@PCN-777 s were highly effective in CO2 capture owing to basic sites on PEI. For example, the best adsorbent (among the studied PCN-777-based adsorbents), PEI(20%)@P777, showed around 2.3 and 5.7 times of adsorption capacity (at 0.15 atm) and selectivity (CO2/N-2), respectively, as much as those of the pristine P777. Moreover, this MOF is recyclable and has the recommended heat of adsorption when adsorbed CO2 is not much. Therefore, it might be suggested that mesoporous MOFs, not suitable for CO2 capture under low pressure (because of too big pore), can be modified facilely for effective CO2 adsorption (especially under low pressure of 1 atm or less) by loading polymers with basicity onto the mesoporous MOFs. | Park, Jong Min; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Jhung, Sung/AAO-6683-2021 | 57193995796; 6701659467 | sung@knu.ac.kr; | JOURNAL OF CO2 UTILIZATION | J CO2 UTIL | 2212-9820 | 2212-9839 | 42 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2020 | 7.132 | 11.5 | 0.79 | 2025-06-25 | 18 | 22 | dsorption; carbon dioxide; metal organic frameworks; PCN-777; porosity | CARBON-DIOXIDE; PROMISING ADSORBENT; POROUS CARBON; LOW-COST; CAPTURE; POLYETHYLENEIMINE; SURFACE; SEPARATION; CONVERSION; MEMBRANES | adsorption; carbon dioxide; metal organic frameworks; PCN-777; porosity | Adsorption; Carbon dioxide; Global warming; Mesoporous materials; Metal-Organic Frameworks; Organometallics; Pore size; Adsorption capacities; CO2 adsorption; Heat of adsorption; Low pressures; Mesoporous metal; Mesoporous MOFs; N2 adsorption; Polyethyleneimine; Organic polymers | English | 2020 | 2020-12 | 10.1016/j.jcou.2020.101332 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Deep Artificial Noise: Deep Learning-Based Precoding Optimization for Artificial Noise Scheme | In this work, we consider a secure precoding optimization problem for the artificial noise (AN) scheme in multiple-input single-output (MISO) wiretap channels. In previous researches (Lin et al., 2013), it was proved that the generalized AN scheme which allows some portion of AN signal to be injected to the legitimate receiver's channel is the optimal precoding scheme for MISO wiretap channels. However, the optimality is valid only under some ideal assumptions such as perfect channel estimation and spatially uncorrelated channels. To break through this limitation, in this paper, we propose a novel deep neural network (DNN)-based secure precoding scheme, called the deep AN scheme. To the best of the authors' knowledge, the deep AN scheme is the first secure precoding scheme which exploits a DNN to jointly design and optimize the precoders for the information signal and the AN signal. From the numerical experiments, it is demonstrated that the proposed deep AN scheme outperforms the generalized AN scheme under various practical wireless environments. | Yun, Sangseok; Kang, Jae-Mo; Kim, Il-Min; Ha, Jeongseok | Queens Univ, Dept Elect & Comp Engn, Kingston, ON K7L 3N6, Canada; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, Sch Elect Engn, Daejeon 34141, South Korea | 56115729600; 56024930400; 36040390300; 7202102842 | sangseok.yun@queensu.ca;jmkang@knu.ac.kr;ilmin.kim@queensu.ca;jsha@kaist.edu; | IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY | IEEE T VEH TECHNOL | 0018-9545 | 1939-9359 | 69 | 3 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS;TRANSPORTATION SCIENCE & TECHNOLOGY | 2020 | 5.978 | 11.5 | 1.75 | 2025-06-25 | 22 | 26 | Artificial noise; deep learning; deep neural network; physical layer security; precoding | SECRECY RATE | Artificial noise; deep learning; deep neural network; physical layer security; precoding | Deep neural networks; Multilayer neural networks; Network layers; Network security; Signal receivers; Artificial noise; MISO wiretap channels; Multiple input single outputs; Numerical experiments; Optimization problems; Physical layer security; Precoding; Wireless environment; Deep learning | English | 2020 | 2020-03 | 10.1109/tvt.2020.2965959 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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