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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Editorial Material PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation Bhusal, Anup; Lee, Won-Ha; Suk, Kyoungho Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea ksuk@knu.ac.kr; NEURAL REGENERATION RESEARCH NEURAL REGEN RES 1673-5374 1876-7958 20 7 SCIE CELL BIOLOGY;NEUROSCIENCES 2024 6.7 9.4 0 INNATE English 2025 2025-07 10.4103/nrr.nrr-d-24-00424 바로가기 바로가기 바로가기
Review Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson's disease A critical unaddressed problem in Parkinson's disease is the lack of therapy that slows or hampers neurodegeneration. While medications effectively manage symptoms, they offer no long-term benefit because they fail to address the underlying neuronal loss. This highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current approaches. Recent clinical trials using gene therapy have demonstrated the safety of various vector delivery systems, dosages, and transgenes expressed in the central nervous system, signifying tangible and substantial progress in applying gene therapy as a promising Parkinson's disease treatment. Intriguingly, at diagnosis, many dopamine neurons remain in the substantia nigra, offering a potential window for recovery and survival. We propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future research. Moreover, innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson's disease. In this review, we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum, offering a novel approach to addressing Parkinson's disease at its core. Sharma, Chanchal; Kim, Sehwan; Eo, Hyemi; Kim, Sang Ryong Kyungpook Natl Univ, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea 57193577728; 57193232250; 59672214100; 56486163800 srk75@knu.ac.kr; NEURAL REGENERATION RESEARCH NEURAL REGEN RES 1673-5374 1876-7958 20 10 SCIE CELL BIOLOGY;NEUROSCIENCES 2024 6.7 9.4 0 2025-05-07 0 0 adeno-associated virus; gene therapy; neuroprotection; neurorestoration; neurotrophic factor; nigrostriatal dopamine pathway; pro-survival protein TRANSDUCTION; MECHANISMS adeno-associated virus; gene therapy; neuroprotection; neurorestoration; neurotrophic factor; nigrostriatal dopamine pathway; pro-survival protein dopamine; neurotrophic factor; Adeno associated virus; corpus striatum; diagnosis; dopaminergic nerve cell; drug therapy; gene targeting; gene therapy; human; nerve cell; nerve degeneration; neuroprotection; nonhuman; Parkinson disease; quality of life; review; substantia nigra; therapy; transgene English 2025 2025-10 10.4103/nrr.nrr-d-24-00724 바로가기 바로가기 바로가기 바로가기
Editorial Material Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus Kim, Jae-Hong; Afridi, Ruqayya; Jang, Il-Sung; Lee, Maan Gee; Suk, Kyoungho Kyungpook Natl Univ, Sch Med, Brain Korea 21 Four KNU Convergence Educ Program B, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea ksuk@knu.ac.kr; NEURAL REGENERATION RESEARCH NEURAL REGEN RES 1673-5374 1876-7958 20 4 SCIE CELL BIOLOGY;NEUROSCIENCES 2024 6.7 9.4 2 WAKEFULNESS; RECEPTOR; NEURONS; GLIA English 2025 2025-04 10.4103/nrr.nrr-d-24-00064 바로가기 바로가기 바로가기
Editorial Material Uncovering optogenetic and chemogenetic induction of cognitive deficits: Efficient techniques for manipulating and observing specific neural activities Suk, Kyoungho Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea ksuk@knu.ac.kr; NEURAL REGENERATION RESEARCH NEURAL REGEN RES 1673-5374 1876-7958 21 1 SCIE CELL BIOLOGY;NEUROSCIENCES 2024 6.7 9.4 0 ASTROCYTES English 2026 2026-01 10.4103/nrr.nrr-d-24-00903 바로가기 바로가기 바로가기
Article Fatigue in hematological cancer changes across chemotherapy trajectory within the context of IL-6, not hemoglobin level: evidence from growth curve modeling PurposeThe present study aimed to examine (a) how fatigue severity changes during the course of chemotherapy in patients with hematologic cancer and (b) whether cytokines (IL-1 alpha, IL-1 beta, IL-6) are associated with fatigue change after controlling for demographic and clinical factors (e.g., hemoglobin/hematocrit, medications, comorbid conditions).MethodsThis observational cohort study used data from 148 hematological cancer patients four times: prior to chemotherapy, on the last day of chemotherapy, 1 week after the chemotherapy completion, and 1 month after baseline assessment. Latent growth curve modeling was used to examine the longitudinal association of fatigue severity with cytokines and hemoglobin.ResultsA quadratic growth curve model fit the data well, indicating model tenability, and explained a large amount of variance in fatigue across measurement time points. Fatigue slightly increased toward the end of chemotherapy and decreased with time after chemotherapy completion. The influence of IL-6 on fatigue was significant at all time points except at the last assessment occasion (i.e., 1 month after the baseline assessment). The influence of IL-6 on fatigue was independent (unique) from the impact of hemoglobin level. Age and chemotherapy given for the first line of treatment significantly influenced the rate of fatigue change over time. Age also influenced the change pattern's shape.ConclusionsFatigue severity changes across the course of chemotherapy within the context of IL-6 activity, not the hemoglobin level. The influence of IL-6 may be limited during and shortly after chemotherapy. These findings inform the development of new symptom management strategies. Kim, Hee-Ju; Moon, Joon Ho; Raykov, Tenko Catholic Univ Korea, Coll Nursing, 222 Banpo Daero, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Michigan State Univ, Measurement & Quantitat Methods, E Lansing, MI USA 36072412200; 56568642700; 7007171074 heeju0906@gmail.com; SUPPORTIVE CARE IN CANCER SUPPORT CARE CANCER 0941-4355 1433-7339 33 3 SCIE HEALTH CARE SCIENCES & SERVICES;ONCOLOGY;REHABILITATION 2024 3 9.5 0 2025-05-07 0 0 Fatigue; Cancer; Oncology; Cytokines; Hemoglobin; Latent growth curve model QUALITY-OF-LIFE; NECROSIS-FACTOR-ALPHA; BREAST-CANCER; SYMPTOM BURDEN; MULTIPLE-MYELOMA; INFLAMMATORY MARKERS; MONOCLONAL-ANTIBODY; GENE POLYMORPHISMS; SLEEP DISTURBANCE; CYTOKINE LEVELS Cancer; Cytokines; Fatigue; Hemoglobin; Latent growth curve model; Oncology Adult; Aged; Antineoplastic Agents; Cohort Studies; Fatigue; Female; Hematologic Neoplasms; Hemoglobins; Humans; Interleukin-6; Longitudinal Studies; Male; Middle Aged; Severity of Illness Index; anthracycline; cytarabine; cytokine; growth factor; hemoglobin; interleukin 1alpha; interleukin 1beta; interleukin 6; steroid; antineoplastic agent; hemoglobin; IL6 protein, human; interleukin 6; adult; aged; Article; blood transfusion; cancer patient; cohort analysis; correlation analysis; disease severity; fatigue; female; growth curve; hematocrit; hemoglobin blood level; high school; human; induction chemotherapy; line of treatment; longitudinal study; major clinical study; male; malignant neoplasm; multiple cycle treatment; observational study; phase 3 clinical trial; predictor variable; statistically significant result; third-line treatment; blood; complication; drug therapy; etiology; hematologic disease; middle aged; severity of illness index English 2025 2025-03 10.1007/s00520-025-09237-8 바로가기 바로가기 바로가기 바로가기
Article Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking Background/Objectives: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized. Therefore, this study aims to investigate the in vivo metabolism of donepezil using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) based on a molecular networking (MN) approach integrated with a non-targeted metabolomics approach. Methods: After the oral administration of donepezil (30 mg/kg) in rats, urine, feces, and liver samples were collected for LC-HRMS analysis. Chromatographic and spectrometric data were processed through MN and multivariate data analysis to identify the in vivo metabolites of donepezil. Results: A total of 50 metabolites were characterized, including 23 newly identified metabolites. Donepezil was biotransformed by O-demethylation, N-debenzylation, and hydroxylation, and these metabolites are further conjugated with glucuronic acid and sulfurous acid. N-Desbenzyldonepezil (M4), didesmethyldonepezil (M5), and N-desbenzyldonepezil (M4) were identified as the most abundant metabolites in urine, feces, and liver samples, respectively. Conclusions: The metabolic characteristics of donepezil in rats were comparable to those in humans, indicating that a rat is a reliable model for studying donepezil metabolism. This study indicates that a MN approach combined with a metabolomics approach is a reliable tool to identify unknown metabolites of drugs and drug candidates. Park, Eun-Ji; Kim, Eui-Hyeon; Kim, Ki-Young; Jeon, Ji-Hyeon; Song, Im-Sook; Park, So-Young; Liu, Kwang-Hyeon Kyungpook Natl Univ, Coll Pharm, BK21 KNU Based Intelligent Novel Drug Discovery Ed, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea 57203611956; 57224532558; 58032476400; 57204685946; 7201564500; 57211630074; 55768214700 roseej98@naver.com; uihyeon1112@naver.com; neanic12@naver.com; kei7016@naver.com; isssong@knu.ac.kr; soyoung1021@knu.ac.kr; dstlkh@knu.ac.kr; PHARMACEUTICS PHARMACEUTICS 1999-4923 17 1 SCIE PHARMACOLOGY & PHARMACY 2024 5.5 9.5 0 2025-05-07 0 0 donepezil; mass spectrometry; metabolism; molecular networking; nontargeted metabolomics IN-VITRO METABOLISM; LIVER donepezil; mass spectrometry; metabolism; molecular networking; nontargeted metabolomics donepezil; liver extract; animal experiment; animal tissue; Article; chemical structure; debenzylation; demethylation; dihydroxylation; Donepezil Metabolism; drug metabolism; hydroxylation; limit of quantitation; liquid chromatography-mass spectrometry; male; mass spectrometry; metabolite; metabolomics; Molecular Networking; network analysis; Non-Targeted Metabolomics; nonhuman; rat; time of flight mass spectrometry English 2025 2025-01 10.3390/pharmaceutics17010115 바로가기 바로가기 바로가기 바로가기
Article Precision mechanical manufacturing and product appearance VR design based on environmental thermal energy control With the global emphasis on environmental protection and sustainable development, the precision machinery manufacturing industry is facing increasingly severe energy consumption and environmental challenges. This study aims to improve the energy efficiency of precision mechanical manufacturing through environmental thermal control technology, and optimize product appearance design by combining virtual reality (VR) technology. A production energy consumption monitoring system based on environmental thermal energy control was proposed through demand analysis of energy consumption in precision machinery manufacturing enterprises. Through system structure and functional design, a manufacturing workshop environmental thermal energy control model was constructed, and system testing experiments were conducted to verify its effectiveness and feasibility. In terms of product appearance VR design, this study explores the interactive design factors of low-carbon manufacturing, analyzes the environmental issues in the product design process, and proposes a VR visualization design scheme for low-energy process planning. Further construction of a product production energy consumption control model aimed at achieving comprehensive energy consumption monitoring throughout the product lifecycle. The research results indicate that the use of environmental thermal control technology and VR design methods can significantly improve the energy efficiency of precision mechanical manufacturing, reduce energy consumption during the product design phase, and enhance the environmental characteristics of the product. This study provides new ideas and methods for precision machinery manufacturing enterprises in environmental protection and sustainable development, promoting technological progress in the industry. Guo, Wei; Liu, Yiming; Li, Yifan Kyungpook Natl Univ, Coll Arts, Daegu 41566, South Korea; Hanyang Univ, Coll Design, Seoul 15588, Gyeonggi Do, South Korea 59468353300; 59468297700; 59468404400 liyifan19940304@163.com; THERMAL SCIENCE AND ENGINEERING PROGRESS THERM SCI ENG PROG 2451-9049 57 SCIE ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS 2024 5.4 9.6 0 2025-05-07 0 0 Environmental thermal energy control; Precision machinery manufacturing; Product appearance; VR Design Environmental thermal energy control; Precision machinery manufacturing; Product appearance; VR Design Energy; Energy-consumption; Environmental thermal energy control; Machinery manufacturing; Mechanical manufacturing; Precision machinery; Precision machinery manufacturing; Product appearance; Thermal; Virtual reality design; Smart manufacturing English 2025 2025-01 10.1016/j.tsep.2024.103124 바로가기 바로가기 바로가기 바로가기
Review A comprehensive review on plant protein-based food packaging: Beyond petroleum-based polymers In the era of biodegradable packaging, protein-based biopolymers have emerged as a sustainable alternative to petroleum-based polymers due to their unique properties. Despite significant advances in this field, a comprehensive analysis of recent technological innovations with commercial viability assessments remains lacking. This review addressed this gap by systematically examining recent lab development in plant protein-based packaging, including sources, fabrication methods, real-time applications, commercial challenges, and their relationship to food packaging applications. Through analysis of recent studies, 2020-2025, we identify recent research trends that have focused on enhancing the properties of biodegradable polymers by incorporating antimicrobial, insecticidal, and antifungal agents, thereby creating active systems to prolong the shelf life of foods. Furthermore, our critical evaluation of advancements in fabrication techniques such as 3D printing, electrospinning, copolymerization, casting, molding, extrusion, and coating has enabled the production of protein-based packaging with diverse shapes and properties. This review uniquely bridges the gap between laboratory innovations and commercial applications by examining current trends in sources, functions, applications, and future commercial challenges associated with plant protein-based packaging. By understanding the potential of these biopolymers, we can contribute to the development of sustainable and innovative packaging solutions within the food industries, offering a roadmap for both researchers and industry stakeholders. Pawde, Subhash V.; Kaewprachu, Pimonpan; Kingwascharapong, Passakorn; Sai-Ut, Samart; Karbowiak, Thomas; Jung, Young Hoon; Rawdkuen, Saroat Mae Fah Luang Univ, Sch Agroind, Unit Innovat Food Packaging & Biomat, Chiang Rai 57100, Thailand; Chiang Mai Univ, Fac Agroind, Samut Sakhon 74000, Thailand; Kasetsart Univ, Fac Fisheries, Dept Fishery Prod, Bangkok 10900, Thailand; Burapha Univ, Fac Sci, Dept Food Sci, Chon Buri 20131, Thailand; Univ Bourgogne Franche Comte, Inst Agro, UMR PAM A02 102, 1 Esplanade Erasme, F-21000 Dijon, France; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea KAEWPRACHU, PIMONPAN/AAK-2605-2020; Jung, YoungHoon/LCE-3750-2024; Pawde, Subhash/ISU-4317-2023; Sai-Ut, Samart/NIS-9008-2025 57219053304; 56520356300; 56708865400; 24438322400; 9333012100; 55550063700; 7801639883 saroat@mfu.ac.th; CURRENT RESEARCH IN FOOD SCIENCE CURR RES FOOD SCI 2665-9271 10 SCIE FOOD SCIENCE & TECHNOLOGY 2024 7 9.7 N/A 0 0 Plant proteins; Food packaging; Sustainability; Commercial challenges; Biopolymer EDIBLE FILMS; FUNCTIONAL-PROPERTIES; PHYSICAL-PROPERTIES; WASTE; SOY; VALORISATION; FABRICATION; COATINGS; CHITOSAN; ZEIN Biopolymer; Commercial challenges; Food packaging; Plant proteins; Sustainability antifungal agent; biopolymer; insecticide; plant protein; polymer; antimicrobial activity; electrospinning; food industry; food packaging; nonhuman; packaging; petroleum; pharmaceutics; polymerization; review; shelf life; three dimensional printing English 2025 2025 10.1016/j.crfs.2025.101104 바로가기 바로가기 바로가기 바로가기
Article Techno-functional of peanut flour substituting on hybrid chicken meatball physico-chemical and nutritional qualities Consumer demand for healthy and sustainable food has driven the development of alternative meat products. This study investigated the effects of substituting peanut flour for chicken meat in meat balls. The hybrid chicken meat balls (HCM) were prepared by replacing chicken breast with 0, 25, 50, and 75 % peanut flour. Proximate composition, physico-chemical properties, textural quality, and protein patterns of HCM were determined. The protein (18.15-20.78 %), fat (0.13-18.71%), fiber (0.56-1.82 %), and ash (1.53-2.32 %) content increased with an increase in peanut flour. The highest cooking yield (99.16 %) was observed at 75 % peanut flour HCM, resulting in the highest juiciness (14.92 %). Texture profile analysis suggested that sample 25 % peanut flour HCM exhibited the most promising textural attributes and higher flour contents resulted in a decline in most textural attributes. HCM with 25 % peanut flour displayed a dense and continuous protein network, whereas 50 and 75 % peanut flour HCM had a looser, more porous structure. The amino acid profile of 25 % peanut flour HCM showed a significant presence of essential amino acids. The study concludes that substituting 25 % peanut flour improves protein and fiber content while maintaining desirable textural attributes, suggesting that peanut flour is a promising and sustainable option for meat ball production. Son, Soklin; Hun, Sreymom; Mazumder, Md Anisur Rahman; Grossmann, Lutz; Kingwascharapong, Passakorn; Sai-ut, Samart; Chaikham, Pittaya; Jung, Young Hoon; Rawdkuen, Saroat Mae Fah Luang Univ, Sch Agroind, Innovat Food Sci & Technol Program, Chiang Rai 57100, Thailand; Royal Univ Phnom Penh Univ, Fac Engn, Bioengn Program, Phnom Penh, Cambodia; Bangladesh Agr Univ, Dept Food Technol & Rural Ind, Mymensingh 2202, Bangladesh; Univ Massachusetts Amherst, Dept Food Sci, 102 Holdsworth Way, Amherst, MA 01003 USA; Kasetsart Univ, Fac Fisheries, Dept Fishery Prod, Bangkok 10900, Thailand; Burapha Univ, Fac Sci, Dept Food Sci, Chon Buri 20131, Thailand; Phranakhon Si Ayutthaya Rajabhat Univ, Div Food Sci & Technol Management, Phranakhon Si Ayutthaya 13000, Thailand; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Mae Fah Luang Univ, Sch Agroind, Unit Innovat Food Packaging & Biomat, Chiang Rai 57100, Thailand Mazumder, Anisur/JBS-0028-2023; Chaikham, Pittaya/JFS-5345-2023; Sai-Ut, Samart/NIS-9008-2025; Jung, YoungHoon/LCE-3750-2024 59753429200; 59753978900; 57189377359; 56497811400; 56708865400; 24438322400; 55207276400; 55550063700; 7801639883 saroat@mfu.ac.th; CURRENT RESEARCH IN FOOD SCIENCE CURR RES FOOD SCI 2665-9271 10 SCIE FOOD SCIENCE & TECHNOLOGY 2024 7 9.7 0 2025-05-07 0 0 Chicken; Hybrid; Meat ball; Nutrition; Plant-based; Peanut SOY PROTEIN; FIBER; ALTERNATIVES; TEMPERATURE; FORMULATION; EXTRUSION; SAUSAGE; PATTIES; FAT; EGG Chicken; Hybrid; Meat ball; Nutrition; Peanut; Plant-based essential amino acid; fat; protein; Article; ash; chicken meat; controlled study; cooking; dietary fiber; food composition; food texture; hybrid chicken meatball; juiciness; mushroom; nutritional value; peanut meal; physical chemistry; polyacrylamide gel electrophoresis English 2025 2025 10.1016/j.crfs.2025.101057 바로가기 바로가기 바로가기 바로가기
Short survey Rethinking cholesterol: the role of lipophilic pollutants [No abstract available] Lee, Duk-Hee; Jacobs, David R.; Lind, P. Monica; Lind, Lars Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu, 700-422, South Korea; Jr., Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States; Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden 57211851121; 57200715827; 7102202987; 26643471200 lee_dh@knu.ac.kr; European Journal of Preventive Cardiology EUR J PREV CARDIOL 2047-4873 2047-4881 32 4 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS 2024 7.5 9.8 0 2025-05-07 0 cholesterol; high density lipoprotein cholesterol; lipoprotein; low density lipoprotein cholesterol; cholesterol; adipose tissue; air pollution; cardiovascular disease; cardiovascular risk factor; human; lipophilicity; persistent organic pollutant; pollutant; risk factor; Short Survey; article English Final 2025 10.1093/eurjpc/zwae350 바로가기 바로가기 바로가기
Article The Effects of Data Restriction Policies and Institutions on Digital Financial Service and Trade Data have become an important factor of production, and their cross-border flows are critical to fostering technological innovation and consumer welfare in the digital-based economy, as well as the development of trade in digital services. On the other hand, many countries regulate cross-border data flows for national security and personal privacy. This study examines the effects of cross-border data restriction policies on digital financial services and trade in the presence of cross-country institutional quality variations. Toward that end, we re-measured the data restriction policy indexes of 60 economies between 2005 and 2018. Using the fixed effects model and the panel 2SLS method, evidence shows that strong data restriction policies significantly negatively affect digital financial services and international trade and that institutional quality attenuates this negative effect. These relationships also vary across six digital service industries and countries (developing vs. developed countries and smaller vs. larger trade countries). Our research provides a policy implication: institutional quality needs to be improved adequately in the face of the worldwide trend of strengthening data restriction policies. Zhang, Hongxia; Kim, Heeho; Moon, Sangkil Shandong Normal Univ, Sch Econ, Jinan, Shandong, Peoples R China; Kyungpook Natl Univ, Sch Econ & Trade, Daehak Ro 80, Daegu 41566, South Korea; Univ North Carolina, Belk Coll Business, Mkt, Charlotte, NC USA ; Kim, Heeho/AAO-8809-2021; Moon, Sangkil/AFF-4790-2022 57199714616; 36727893700; 12139851200 kimhh@knu.ac.kr; EMERGING MARKETS FINANCE AND TRADE EMERG MARK FINANC TR 1540-496X 1558-0938 61 9 SSCI BUSINESS;ECONOMICS;INTERNATIONAL RELATIONS 2024 3.1 9.8 0 2025-05-07 1 1 Data flow restrictions; digital trade rules; institutional quality; digital financial service trade; digital technology; F10; F23; F68 FOREIGN DIRECT-INVESTMENT; FDI INFLOWS; QUALITY; ECONOMY; FLOWS Data flow restrictions; digital financial service trade; digital technology; digital trade rules; institutional quality English 2025 2025-07-15 10.1080/1540496x.2025.2467190 바로가기 바로가기 바로가기 바로가기
Article Deep learning for NAD/NADP cofactor prediction and engineering using transformer attention analysis in enzymes Understanding and manipulating the cofactor preferences of NAD(P)-dependent oxidoreductases, the most widely distributed enzyme group in nature, is increasingly crucial in bioengineering. However, large-scale identification of the cofactor preferences and the design of mutants to switch cofactor specificity remain as complex tasks. Here, we introduce DISCODE (Deep learning-based Iterative pipeline to analyze Specificity of COfactors and to Design Enzyme), a novel transformer-based deep learning model to predict NAD(P) cofactor preferences. For model training, a total of 7,132 NAD(P)-dependent enzyme sequences were collected. Leveraging whole-length sequence information, DISCODE classifies the cofactor preferences of NAD(P)dependent oxidoreductase protein sequences without structural or taxonomic limitation. The model showed 97.4% and 97.3% of accuracy and F1 score, respectively. A notable feature of DISCODE is the interpretability of its transformer layers. Analysis of attention layers in the model enables identification of several residues that showed significantly higher attention weights. They were well aligned with structurally important residues that closely interact with NAD(P), facilitating the identification of key residues for determining cofactor specificities. These key residues showed high consistency with verified cofactor switching mutants. Integrated into an enzyme design pipeline, DISCODE coupled with attention analysis, enables a fully automated approach to redesign cofactor specificity. Kim, Jaehyung; Woo, Jihoon; Park, Joon Young; Kim, Kyung-Jin; Kim, Donghyuk Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Ulsan 44919, South Korea; Kyungpook Natl Univ, KNU Inst Microbiol, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea Kim, Kyung-Jin/MVY-3405-2025 58847263800; 58515549300; 57211378045; 55510867400; 55759502300 dkim@unist.ac.kr; METABOLIC ENGINEERING METAB ENG 1096-7176 1096-7184 87 SCIE BIOTECHNOLOGY & APPLIED MICROBIOLOGY 2024 6.8 9.9 3.66 2025-05-07 0 2 NAD(P) specificity; Cofactor switching; Deep learning; Explainable AI; Protein engineering; Synthetic biology COENZYME SPECIFICITY; REDUCTASE; BINDING; CLASSIFICATION; DEHYDROGENASE; PREFERENCE; PHOSPHATE; SUBSTRATE; SEQUENCE Cofactor switching; Deep learning; Explainable AI; NAD(P) specificity; Protein engineering; Synthetic biology Deep Learning; NAD; NADP; Protein Engineering; nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide phosphate; oxidoreductase; Cofactor preferences; Cofactor specificity; Cofactor switching; Cofactors; Deep learning; Explainable AI; NAD(P) specificity; Oxido-reductases; Protein engineering; Synthetic biology; allosterism; amino acid sequence; Article; catalytic efficiency; deep learning; deep neural network; degradation; engineering; entropy; enzyme analysis; Neurospora crassa; prediction; protein engineering; synthetic biology; temperature; genetics; metabolism; procedures; protein engineering; Biochemical engineering English 2025 2025-01 10.1016/j.ymben.2024.11.007 바로가기 바로가기 바로가기 바로가기
Article Enhanced mechanical properties of α-phase LA51 alloy using caliber rolling This study investigates the microstructural evolution and mechanical properties of the Mg-5Li-1Al (LA51, wt.%) alloy, aimed at developing a high strength single-phase Mg-Li alloy. The alloy was successfully produced using caliber rolling (CR) with varying rolling reductions (i.e., 38 %, 65 %, 80 %). The results indicate that CR effectively reduces the grain size from similar to 68.5 mu m to similar to 8.1 mu m. The primary mechanisms of grain refinement include continuous dynamic recrystallization (CDRX), discontinuous dynamic recrystallization (DDRX), and twin-induced recrystallization (TDRX). With an increase in rolling reduction to 80 %, the tensile yield strength (TYS), ultimate tensile strength (UTS), and elongation (El.) of the LA51 alloy reach 265.7 MPa, 324.2 MPa, and 11.9 %, respectively. Furthermore, CR significantly enhances the tensile-compressive asymmetry of LA51 alloy as well. The improved mechanical properties of such alloy are attributed to grain refinement and dislocation strengthening mechanisms. Yu, Hui; Li, Na; Ma, Hanyu; Yu, Wei; He, Zhixin; Xu, Qiong; Cheng, Weili; Park, Sung Hyuk; Shin, Kwang Seon; Liu, Chao Hebei Univ Technol, Belt & Rd Initiat Adv Mat Int Joint Res Ctr Hebei, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China; PLA AAAAD, Hefei 130022, Peoples R China; Anhui Univ Chinese Med, Sci & Technol Ind Pk, Hefei 230012, Peoples R China; Anhui Jianzhu Univ, Sch Mat & Chem Engn, Hefei 230022, Peoples R China; Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan 030024, Peoples R China; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Seoul Natl Univ, Magnesium Technol Innovat Ctr, Seoul 08826, South Korea hanyu_ma@163.com; yuwei52213@163.com; sk8liuchao@163.com; JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T J MATER RES TECHNOL 2238-7854 2214-0697 36 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING 2024 6.6 9.9 0 Mg-Li alloy; Caliber rolling; Microstructure; Mechanical properties TENSILE PROPERTIES; MG ALLOY; GRAIN-BOUNDARY; CRYSTALLOGRAPHIC TEXTURE; MAGNESIUM ALLOY; LOW-TEMPERATURE; SOLID-SOLUTION; SERRATED FLOW; MICROSTRUCTURE; STRENGTH English 2025 2025 (MAY-JUN) 10.1016/j.jmrt.2025.04.259 바로가기 바로가기 바로가기
Article Enhancing the microstructural homogeneity and mechanical properties of recycled 7xxx series Al extrudates via grain refiner addition This study presents a recycling method for 7xxx series Al chips from milling to produce extruded materials with enhanced mechanical properties. Milling chips were compressed and melted with ingots (1:1 weight ratio) to form billets for extrusion. During casting, an Al-5Ti-1B grain refiner (GR) was added, reducing the average grain size of the cast alloy from several millimeters to approximately 90 mu m. Following extrusion, the GR-free extrudate exhibited an average grain size of 138 mu m, while the GR-containing extrudate demonstrated a finer grain size of 36 mu m. This refined microstructure resulted in enhanced grain boundary strengthening. The GRcontaining extrudate achieved a tensile yield strength (TYS) of 273 MPa, an ultimate tensile strength of 439 MPa, and an elongation of 15.8%, surpassing the TYSs of the GR-free extrudate (243 MPa) and commercial AA7075 extrudate (230 MPa). Three-point bending tests revealed that the GR-containing extrudate displayed a limiting bending depth (LBD) of 9.0 mm and failure bending strain of 42.3%, compared to the LBD of 6.5 mm and failure bending strain of 30.7% of the GR-free extrudate. The improved bendability of the former is attributed to its fine, uniform microstructure and slip-favorable textures formed by GR addition, reducing stress concentrations and improving bending formability. Overall, GR addition to recycled Al alloys effectively enhanced their mechanical properties beyond those of commercial AA7075, despite milling chip addition. This method provides a viable approach for Al chip recycling, offering a sustainable solution to reduce waste and improve resource efficiency in the Al industry. Jin, Sang-Cheol; An, Gun Woong; Kim, Hyung Jun; Yoon, Jae Hoon; Park, Ki Tae; Song, Kyung Hwan; Son, Ki Doc; Lee, Jeong Hun; Park, Sung Hyuk Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, Kyungpook, South Korea; Kyungpook Natl Univ, Grad Sch Mat Sci & Engn, Daegu 41566, South Korea; Samsung Elect, Adv Mecha Grp, Suwon 16677, South Korea; Kyungpook Natl Univ, Sch Dent, Daegu 41940, South Korea 57198914140; 59298471300; 59655575300; 59656100700; 57205567496; 59655838500; 59655838600; 54785958500; 54786002500 sh.park@knu.ac.kr; JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T J MATER RES TECHNOL 2238-7854 2214-0697 35 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING 2024 6.6 9.9 0 2025-05-07 0 0 Aluminum alloy; Milling chip; Recycling; Tensile property; Bendability STRAIN-GRADIENT PLASTICITY; DUCTILE FRACTURE; AL-5TI-1B; RECRYSTALLIZATION; NUCLEATION; GROWTH; FE Aluminum alloy; Bendability; Milling chip; Recycling; Tensile property Aluminum castings; Aluminum refining; Bending (forming); Bending strength; Billets (metal bars); Extrusion; Grain refinement; Milling machines; Stretching; Tensile strength; 7xxx series; Average grain size; Bending strain; Extrudates; Grain refiner; Mechanical; Microstructural homogeneity; Milling chip; Property; Refiner addition; Milling (machining) English 2025 2025 (MAR-APR) 10.1016/j.jmrt.2025.02.220 바로가기 바로가기 바로가기 바로가기
Article Improvement in tensile ductility and aging response of high-speed-extruded Mg-5Bi-3Al alloy via trace Zn addition This study examines the effects of trace Zn addition on the microstructure, tensile properties, and precipitation behavior of a high-speed-extruded Mg-5Bi-3Al (BA53, wt.%) alloy. While this alloy exhibits excellent extrudability and high strength, its low ductility and prolonged aging time to achieve peak hardness limit its commercial viability. To address these limitations, 0.5 wt.% Zn was added to the BA53 alloy to enhance its ductility and reduce its peak-aging time without compromising its strength. Subsequently, BA53 and Mg-5Bi-3Al-0.5Zn (BAZ530) alloys were extruded at 400 degrees C with a die-exit speed of 40 m/min. Microstructural analysis revealed that trace Zn addition had minimal impact on grain size or Mg3Bi2 particle distribution but reduced the maximum texture intensity of the high-speed-extruded alloy. The BAZ530 alloy demonstrated a 38% increase in tensile elongation compared to the BA53 alloy, with no reduction in tensile yield strength, primarily due to the activation of non-basal slip systems. In addition to improving ductility, Zn addition significantly reduced the peak-aging time at 180 degrees C from 128 h for the BA53 alloy to 16 h for the BAZ530 alloy, an eightfold decrease, while achieving comparable peak hardness values. This acceleration is attributed to the substitution of Bi atoms by Zn atoms in the Mg3Bi2 phase, which lowered the formation enthalpy and increased nucleation rates. Overall, our findings demonstrate that trace Zn addition effectively enhances tensile elongation and accelerates precipitation in high-alloyed Mg-Bi-Al alloys. Jin, Sang-Cheol; An, Gun Woong; An, Je Hyeong; Lee, Jeong Hun; Park, Yejun; Choi, Pyuck-Pa; Park, Sung Hyuk Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Dent, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Mat Sci & Engn, Daejeon 34141, South Korea sh.park@knu.ac.kr; JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T J MATER RES TECHNOL 2238-7854 2214-0697 36 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING 2024 6.6 9.9 0 Mg-Bi alloy; High-speed extrusion; Zn addition; Mechanical properties; Age hardening STRAIN-GRADIENT PLASTICITY; MECHANICAL-PROPERTIES; GRAIN-SIZE; DEFORMATION-BEHAVIOR; MICROSTRUCTURE; MG; TEXTURE; BERYLLIUM; EXTRUSION; MODES English 2025 2025 (MAY-JUN) 10.1016/j.jmrt.2025.03.307 바로가기 바로가기 바로가기
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