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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Enantioselective toxicity of (S)-amlodipine towards zebrafish embryos: Abnormal ocular development, cardiac dysfunction, and malformed intersegmental vessels | Amlodipine (AM), widely used for the treatment of hypertension and angina, consists of two enantiomers: (S)-AM and (R)-AM. The extensive use of this medication has raised concerns regarding environmental contamination, but the enantioselective toxicity of AM in aquatic organisms has not been adequately investigated. This study aimed to examine the enantioselective toxicity of AM using zebrafish (Danio rerio) embryos, focusing on acute toxicity and developmental toxicity. Neither enantiomer exhibited acute toxicity at the tested concentrations (0.25-20 mg/L). With respect to ocular development, (R)-AM reduced eye volume at the highest tested concentration. The lens-to-eye volume ratio showed a significant increase in embryos treated with both enantiomers compared to the control. Enantioselective toxicity was evident in cardiac function, as (S)-AM-induced heart dysfunction, despite both enantiomers displaying similar patterns of heart development-related gene expression. Severe defects in ISV formation were observed in both (S)-AM and (R)-AM treatments, indicating that AM exposure may result in abnormal blood vessel formation in other fish. Metabolomic analysis indicated that exposure to either enantiomer led to the upregulation of most metabolic pathways, except for starch and sucrose metabolism. Further research needs to confirm enantioselective toxicity under chronic conditions at environmentally relevant concentrations of AM. | Kim, Chaeeun; Kim, Donghyeon; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | 57200245142; 57780824900; 59896108900 | selpest@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 298 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | 2025-06-11 | 0 | 0 | Enantiomers; Amlodipine; Enantioselective toxicity; Abnormal ocular development; Heart dysfunction | INTRAVENOUS LIPID EMULSION; EYE DEVELOPMENT; AMLODIPINE; PHARMACEUTICALS; KNOCKDOWN; GENE | Abnormal ocular development; Amlodipine; Enantiomers; Enantioselective toxicity; Heart dysfunction | Amlodipine; Animals; Embryo, Nonmammalian; Eye; Heart; Stereoisomerism; Water Pollutants, Chemical; Zebrafish; amlodipine; paraformaldehyde; potassium iodide; starch; sucrose; trizol; amlodipine; concentration (composition); cyprinid; drug; embryo; gene expression; toxicity; abnormal ocular development; adult; angina pectoris; animal experiment; animal model; Article; congenital blood vessel malformation; controlled study; discriminant analysis; embryo; enantiomer; enantioselectivity; eye disease; female; fractional shortening; gas chromatography; gene expression; heart disease; heart function; heart rate; high performance liquid chromatography; hypertension; intersegmental vessel; male; mass spectrometry; metabolism; metabolite; metabolomics; micro-computed tomography; mRNA expression level; nonhuman; principal component analysis; quality control; real time polymerase chain reaction; RNA extraction; software; time of flight mass spectrometry; toxicity; toxicity testing; upregulation; zebra fish; animal; chemistry; drug effect; embryology; eye; heart; nonmammalian embryo; stereoisomerism; water pollutant; zebra fish | English | 2025 | 2025-06-15 | 10.1016/j.ecoenv.2025.118315 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Evaluation of Dynamic Light Scattering as an Effective Quality Control Method for Aggregates in Radiolabeled Antibodies | Radiolabeled antibodies are promising for targeted cancer imaging, but their structural integrity may suffer during bioconjugation and radiolabeling, leading to undetected aggregation. This study evaluates dynamic light scattering (DLS) as a complementary method to size-exclusion high-performance liquid chromatography (SEC-HPLC) for detecting aggregation in radiolabeled antibodies. Trastuzumab was conjugated with a NOTA bifunctional chelator at various ratios, radiolabeled with [64Cu]CuCl2, and analyzed by using DLS and SEC-HPLC before and after purification. DLS revealed significant aggregation during preparation, undetected by SEC-HPLC, and showed reduced aggregates following purification. Tumor-targeting efficacy correlated with intact antibody content, with Pearson’s correlations of 0.71 (PET imaging) and 0.75 (biodistribution) in NIH3T6.7 tumor-bearing mice. The findings suggest DLS as a vital quality control tool, offering enhanced detection of antibody aggregation. By adopting DLS, the bioactivity of radiolabeled antibodies can be better predicted, potentially improving the reliability and effectiveness of these radiopharmaceuticals in clinical settings. © 2024 American Chemical Society. | Nguyen, Huu Bao; Park, Hyun; Lim, Jeong Eun; Nguyen, Thuy Tien; Kim, Hwan Hui; Kim, Kyeongwon; Kim, Jung Young; Lee, Kyo Chul; Yoo, Jeongsoo | Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, 01812, South Korea; Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, 01812, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, 01812, South Korea; Department of Molecular Medicine, Brain Korea 21 Four KNU Convergence Educational, Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea | 59476933500; 56175671100; 57732661800; 59476802200; 59476933600; 59476553200; 7601371677; 42661704100; 8215136400 | yooj@knu.ac.kr; | Journal of Medicinal Chemistry | J MED CHEM | 0022-2623 | 1520-4804 | 68 | 1 | SCIE | CHEMISTRY, MEDICINAL | 2024 | 6.8 | 9.0 | 0 | 2025-05-07 | 0 | Animals; Cell Line, Tumor; Chelating Agents; Chromatography, High Pressure Liquid; Copper Radioisotopes; Dynamic Light Scattering; Female; Humans; Mice; Positron-Emission Tomography; Protein Aggregates; Quality Control; Radiopharmaceuticals; Tissue Distribution; Trastuzumab; copper nota trastuzumab cu 64; protein aggregate; radiopharmaceutical agent; unclassified drug; chelating agent; copper; Copper-64; protein aggregate; radiopharmaceutical agent; trastuzumab; 3T6-Swiss albino cell line; animal experiment; animal model; animal tissue; Article; controlled study; drug conjugation; drug distribution; drug purification; drug targeting; evaluation study; female; high performance liquid chromatography; in vivo study; intermethod comparison; mouse; nonhuman; photon correlation spectroscopy; positron emission tomography; quality control; radiolabeling; size exclusion chromatography; animal; chemistry; human; tissue distribution; tumor cell line | English | Final | 2025 | 10.1021/acs.jmedchem.4c02344 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Low and high-density polyethylene and expanded polystyrene biodegradation by the greater wax moth Galleria mellonella L reveals a key role of the gut microbiome. | Polyethylene (PE) is a ubiquitous pollutant that takes long time to degrade naturally. PE breaks down into persistent micro-or nano-plastics that are even more dangerous for the environment and human health. Here we investigated the ability of the wax worm Galleria mellonella (Lepidoptera, Pyralidae) to degrade two different types of PE and expanded polystyrene (EPS). Results showed a reduction of up to 69 %, 73 %, and 50 % in the weight of LDPE, HDPE, and EPS, respectively. Antibiotic treatments indicated that PE consumption is highly dependent upon an intact population of at least eight different bacteria from the Enterococcus, Pseudomonas, and Bacillus genera identified by 16S rRNA sequencing. Antibiotic treatment reduced the gut bacterial population, negatively affecting larval growth. The PE-only diet severely affected the growth and development of G. mellonella larvae, pupae, and male/female adults. SEM analysis of gut bacteria co-incubated LDPE discs revealed biofilm formation and PE biodegradation by all the bacteria in the culture, supporting the great potential of these bacteria for plastic biodegradation. FTIR analysis of frass after feeding on PE only revealed significantly strong PE biodegradation signals as results showed 33 peaks of strong (S) and medium (M) intensity corresponding to wave numbers with PE biodegradation signatures ranging between 1239.50 cm-1 to 3077.69 cm-1 coding for vinyl hydrocarbons, vinyl ether, vinylene, vinylene trisubst., ketones, ethers, aldehydes, acrylate, diazo ketones and epoxides which is a convincing evidence of PE metabolism. Further research is required to determine the practical implications of wax worm larvae for plastic degradation in the environment. | Kehkashan; Hussain, Adil; Murtaza, Muhammad; Lee, Geum-Jin; Mun, Bong-Gyu; Yun, Byung-Wook | Abdul Wali Khan Univ Mardan, Dept Entomol, Mardan 23200, Khyber Pakhtunk, Pakistan; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Chungbuk Natl Univ, Dept Environm & Biol Chem, Cheongju, South Korea | ; Mun, BongGyu/GYD-6010-2022; Hussain, Dr. Adil/K-6016-2018 | 58150418600; 41961162600; 59696801800; 59362270300; 57147241300; 8245123600 | adilhussain@awkum.edu.pk; bwyun@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 294 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | 2025-05-07 | 0 | 0 | Polyethylene; Biodegradation; Galleria mellonella; Gut microbiome; SEM; FTIR | DIET | Biodegradation; FTIR; Galleria mellonella; Gut microbiome; Polyethylene; SEM | Animals; Bacteria; Biodegradation, Environmental; Environmental Pollutants; Female; Gastrointestinal Microbiome; Larva; Male; Moths; Polyethylene; Polystyrenes; RNA, Ribosomal, 16S; polyethylene; polyethylene terephthalate; polystyrene; polystyrene derivative; RNA 16S; biodegradation; degradation; FTIR spectroscopy; microorganism; moth; plastic waste; scanning electron microscopy; adult; Article; Bacillus; Bacillus velezensis; biodegradation; controlled study; egg laying; Enterococcus; female; fluorescence microscopy; Fourier transform infrared spectroscopy; Galleria mellonella; gene expression; intestine flora; larva; male; microbial community; microbial diversity; microbial identification; microbiome; nonhuman; nucleotide sequence; Pseudomonas; pupa; pupation; RNA sequencing; scanning electron microscopy; animal; bacterium; bioremediation; drug effect; genetics; growth, development and aging; metabolism; microbiology; moth; pollutant | English | 2025 | 2025-04-01 | 10.1016/j.ecoenv.2025.118074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Plumbagin, a natural derivative of 1,4-naphthoquinone, induces cyclopic phenomenon via increased apoptosis and ROS generation in the early stage of zebrafish embryos | Plumbagin (PL; 5-hydroxy-2-methyl-1,4-naphthoquinone) is an analogue of juglone (JG) with additional methylation on carbon 2. It has been found in fungi, insects, and plants, especially Malaysian persimmons, and plants containing PL are globally used as folk medicines. Among 1,4-naphthoquinones tested in this study, PL and JG exhibited high lethality towards zebrafish (Danio rerio) embryos and reduced their hatchability, and induced morphological changes. In addition, zebrafish embryos exposed to 0.13 mu M of PL at 4 h post-fertilization exhibited severely reduced brain differentiation in a PL concentration-dependent manner, resulting in severe cyclopia symptoms, with individuals experiencing cyclopia ultimately dying. The cyclopia induced by PL was more severe than that of the positive controls, ethanol, forskolin, and cyclopamine. Increased apoptosis and reactive oxygen species (ROS) generation were associated with PL-induced cyclopia, and concurrent treatments with ROS-quenching curcuminoids decreased cyclopia. Metabolomic activity in PL-treated embryos was also severely disrupted, and even surviving individuals would likely not retain proper function. Thus, plants should be monitored for the presence of PL, given its strong cyclopia-inducing effects on animals. Due to the high frequency and severity of symptomatic zebrafish embryos in this study, PL's association with holoprosencephaly, specifically cyclopia, is undeniable. | Lim, Yeonju; Kim, Chaeeun; Kim, Donghyeon; Kim, Myoung-Jin; Yu, Ji-Woo; Song, Min-Ho; Kim, Yurim; Son, Junhee; Lee, Ji-Ho; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Nakdonggang Natl Inst Biol Resources, Res Planning & Management Div, Sangju 37242, South Korea; Konkuk Univ, Dept Crop Sci, 120 Neungdong Ro, Seoul 05029, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Dept Biol Environm, Chunchon 24341, South Korea | 59299145900; 57200245142; 57780824900; 57191626729; 57297132700; 57216764409; 57397370800; 59903534000; 56341609900; 59896108900 | selpest@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 302 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | N/A | 0 | 0 | Plumbagin; Cyclopia; Zebrafish embryos; Apoptosis; ROS generation; 1,4-Naphthoquinones | VERATRUM CALIFORNICUM DURAND; TERATOGENIC COMPOUNDS; DITERPENE ESTERS; ALKALOIDS; EUPHORBIACEAE; INHIBITION; TOXICITY; DYNAMICS; IRRITANT; BINDING | 1,4-Naphthoquinones; Apoptosis; Cyclopia; Plumbagin; ROS generation; Zebrafish embryos | alcohol; curcumin; cyclopamine; forskolin; plumbagin; reactive oxygen metabolite; apoptosis; concentration (composition); cyprinid; dose-response relationship; embryonic development; methylation; organic compound; reactive oxygen species; survival; animal experiment; apoptosis; Article; brain differentiation; concentration (parameter); controlled study; cyclopia; cyclopic phenomenon; developmental biology; disease severity; dying; EC50; embryo; female; fertilization; incidence; LC50; male; metabolomics; methylation; micro-computed tomography; nonhuman; physiology; real time reverse transcription polymerase chain reaction; symptom; toxicity testing; zebra fish | English | 2025 | 2025-09-01 | 10.1016/j.ecoenv.2025.118535 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Proteomic evaluation of pathways associated with phosphine-induced mitochondrial dysfunction and resistance mechanisms in Tribolium castaneum against phosphine fumigation: Whole and partial proteome identification | Phosphine (PH3) fumigation is widely used to control insect pests in stored products globally. However, intensive PH3 use has led to the emergence of significant resistance in target insects. To address this issue, this study investigated PH3 resistance mechanisms by conducting both qualitative and quantitative proteomic analyses on the whole proteome of a PH3-resistant Tribolium castaneum strain (AUS-07) using LC-MS/MS. Besides, proteins from both strains were separated in 1D-PAGE, and qualitatively analyzed using LC-MS/MS after in-gel digestion. Differentially expressed proteins (DEPs) with cut-off values (4-fold expression difference and p < 0.05) were selected, and 107 proteins were identified in the AUS-07 strain. Among them, several proteins involved in oxidative phosphorylation were notably upregulated in response to PH3 exposure. Upregulation of Complex I and III in the electron transport chain of the AUS-07 strain may lead to the excessive generation of reactive oxygen species (ROS) in the form of superoxide, which can damage Fe-S cluster-containing proteins such as cytochrome P450s (CYP450s). Upregulation of detoxifying enzymes, such as CYP450s and glutathione S-transferases (GSTs), was observed, likely to repair superoxide-induced damage on CYP450s as well as quenching superoxide. Upregulation of aldose reductases involved in polyol pathways and downregulation of the trehalose transporter were observed, suggesting that PH3-resistance may be linked to diapause-like physiological adaptations, including quiescence. Further studies are essential to quantify polyol levels in the AUS-07 strain and to conduct other molecular analyses to validate the roles of identified DEPs in PH3 resistance. Altogether, our findings suggest a new control strategy to stored product insect pests by other type of fumigant such as ethyl formate with different molecular structure. | Kim, Donghyeon; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | 57780824900; 55890041600 | selpest@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 289 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | 2025-05-07 | 0 | 0 | Whole proteome; LC-MS/MS; PH 3-resistance; Tribolium castaneum; Oxidative Phosphorylation | CYP346 FAMILY GENES; INSECTICIDE RESISTANCE; STORED-PRODUCT; MANAGEMENT; DIAPAUSE | LC-MS/MS; Oxidative Phosphorylation; PH<sub>3</sub>-resistance; Tribolium castaneum; Whole proteome | Animals; Fumigation; Insect Proteins; Insecticide Resistance; Insecticides; Mitochondria; Phosphines; Proteome; Proteomics; Reactive Oxygen Species; Tandem Mass Spectrometry; Tribolium; glutathione transferase; phosphine; reactive oxygen metabolite; insect protein; insecticide; phosphine; phosphine derivative; proteome; reactive oxygen metabolite; fumigant; fumigation; insect; mass spectrometry; mitochondrion; proteomics; Article; bioinformatics; chemical structure; disorders of mitochondrial functions; drug sensitivity; electron transport; fumigation; gene ontology; high performance liquid chromatography; LC50; mass spectrometry; mitochondrial dysfunction; nonhuman; oxidative phosphorylation; principal component analysis; protein analysis; protein expression; proteomics; real time reverse transcription polymerase chain reaction; Tribolium castaneum; upregulation; animal; drug effect; insecticide resistance; metabolism; mitochondrion; proteomics; tandem mass spectrometry; Tribolium | English | 2025 | 2025-01-01 | 10.1016/j.ecoenv.2024.117652 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Stereoisomeric developmental toxicity of orysastrobin and its isomeric metabolite in zebrafish (Danio rerio) embryos: Cardiac abnormal development by orysastrobin | Orysastrobin (OSB), a strobilurin fungicide, inhibits the normal redox reactions of cytochrome bc1 at the Qo site of target phytopathogenic fungal species. Its frequent detection and high concentrations in natural wetlands and rivers have raised concerns regarding its acute toxicity and potential effects on fish. Therefore, this study examined the acute toxicities of OSB and its stereoisomeric metabolite F001 on zebrafish (Danio rerio) embryos, an animal model. OSB and F001 did not induce substantial mortality or inhibit hatching in the treated embryos. However, OSB exhibited acute toxicities, including pericardial and yolk sac edemas, spine curvature, and bleeding, at 5.0 mg/L concentration. In contrast, F001 did not induce such abnormalities in zebrafish embryos within the tested concentration ranges. Additionally, OSB induced abnormal cardiac development and significantly impaired heart function in embryos, likely due to the up-regulation of key heart development genes, such as kcnn6a and amhc. In OSB-treated embryos, a developmental delay in liver formation was observed. OSBinduced reactive oxygen species in zebrafish embryos. Overall, this study underscores the importance of gathering comprehensive toxicological data on OSB and F001 in fish to fully understand their environmental impacts, emphasizing the urgent need for repeated periodic monitoring to mitigate the environmental risks posed in agricultural waters, reservoirs, and other aquatic ecosystems. | Son, Junhee; Kim, Chaeeun; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | 59903534000; 57200245142; 59896108900 | selpest@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 299 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | 2025-06-11 | 0 | 0 | Cardiac development; Stereoselective toxicity; Environmental impact; Gene expression; Orysastrobin; Zebrafish embryo | STROBILURIN FUNGICIDE; AZOXYSTROBIN; FATE; ANTIBIOTICS; RESISTANCE; EXPOSURE | Cardiac development; Environmental impact; Gene expression; Orysastrobin; Stereoselective toxicity; Zebrafish embryo | Animals; Embryo, Nonmammalian; Embryonic Development; Fungicides, Industrial; Heart; Strobilurins; Water Pollutants, Chemical; Zebrafish; acridine orange; carboxylic acid derivative; cytochrome b; fungicide; orysastrobin; reactive oxygen metabolite; unclassified drug; fungicide; strobilurin; embryo; environmental impact; environmental risk; fish; fungicide; gene expression; metabolite; reactive oxygen species; toxicity; toxicology; amhc gene; animal experiment; animal model; aquatic environment; Article; bleeding; controlled study; developmental delay; developmental toxicity; edema; egg yolk; electrospray mass spectrometry; embryo; environmental impact assessment; environmental risk; fluorescence microscopy; fungal strain; gene; gene expression; hatching; heart development; heart function; heart rate; high performance liquid chromatography; kcnn6a gene; limit of detection; metabolite; mortality; multiple reaction monitoring; nonhuman; oxidation reduction reaction; pericardial disease; pericardial edema; phenotype; phytopathogen; real time polymerase chain reaction; rearing; redox signaling; staining; statistical analysis; stereoisomerism; survival rate; toxicological parameters; transgenic fish; upregulation; wetland; yolk sac; zebra fish; animal; chemistry; drug effect; embryo development; embryology; heart; nonmammalian embryo; toxicity; water pollutant | English | 2025 | 2025-07-01 | 10.1016/j.ecoenv.2025.118391 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Stereoselective toxicity of (E)-kresoxim-methyl to zebrafish (Danio rerio) embryos during development and metabolomic approaches using GC-MS/MS | Kresoxim-methyl (KM) is a stereoselective strobilurin fungicide with low toxicity to humans, mammals, and beneficial insects. At the frequent detection of KM in aquatic environments, its stereoisomeric form may cause different acute toxicity for aquatic organisms. The acute toxicities of both stereoisomers, (E)-KM and (Z)-KM, as well as their demethylated metabolite, kresoxim, were evaluated in zebrafish (Danio rerio) embryos. Specifically, the embryos were exposed to the three compounds to assess survival rate, hatchability, and morphological changes. The results showed that embryos exposed to (E)-KM at 0.5 mg/L exhibited various abnormal phenotypes, including yolk swelling and pericardiac edema. In the Tg(cmlc2:EGFP) line, the heart rate was significantly reduced upon exposure to 0.5 mg/L of (E)-KM. Vascular development was assessed using the Tg(fli1a:EGFP) line. (E)-KM induced apoptosis in a dose-dependent manner, leading to highly upregulated expression of il-1β, a biomarker of inflammasome activation. Metabolomic changes in (E)-KM-treated embryos were strongly associated with the downregulation of energy metabolism. Taken together, our findings demonstrate that (E)-KM displays stereoselective toxicity to zebrafish embryos, affecting their early development stages and posing a potential risk to various aquatic organisms. © 2025 The Authors | Son, Junhee; Yu, Ji-Woo; Kim, Chaeeun; Choi, Eun-Song; Lee, Ji-Ho; Lee, Sung-Eun | Department of Integrative Biology, Kyungpook National University, Daegu, 41566, South Korea; Department of Crop Science, College of Sang-Huh Life Science, Konkuk University, Seoul, 05029, South Korea, School of Natural Resources and Environmental Science, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea; Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, South Korea; School of Natural Resources and Environmental Science, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea; School of Natural Resources and Environmental Science, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 24341, South Korea; Department of Integrative Biology, Kyungpook National University, Daegu, 41566, South Korea, Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, South Korea | 59903534000; 57297132700; 57200245142; 59939428800; 56341609900; 59896108900 | selpest@knu.ac.kr; | Ecotoxicology and Environmental Safety | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 302 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | (E)-Kresoxim-methyl; (Z)-Kresoxim-methyl; Apoptosis; Developmental arrest; Metabolomic analysis; Stereoisomers | biological marker; complementary DNA; glyceraldehyde 3 phosphate dehydrogenase; inflammasome; interleukin 1beta; isoleucine; kresoxim methyl; leucine; messenger RNA; pantothenic acid; strobilurin; unclassified drug; valine; apoptosis; cyprinid; embryonic development; fungicide; gas chromatography; mass spectrometry; metabolism; metabolite; toxicity; acute toxicity; adult; angiogenesis; animal experiment; apoptosis; aquatic species; Artemia; Article; baxa gene; body height; brain size; cell maturation; demethylation; detoxification; developmental stage; developmental toxicity; down regulation; EC50; embryo; energy metabolism; female; fluorescence intensity; fluorescence microscopy; gene; gene expression; hatchability; heart edema; heart rate; inflammation; LC50; male; mass fragmentography; metabolite; metabolomics; multiple reaction monitoring; nerve cell differentiation; nonhuman; pericardiac edema; phenotype; real time polymerase chain reaction; respiratory chain; risk factor; RNA extraction; stereoisomerism; stereomicroscopy; stereoselectivity; survival rate; ultrasound; upregulation; zebra fish | English | Final | 2025 | 10.1016/j.ecoenv.2025.118571 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Structural feasibility of segmental prestressed concrete box girders with multi-directional dry joints and unbonded tendons | This study aims to investigate the structural feasibility of segmental prestressed concrete box girders with multidirectional joints, which are positioned in both longitudinal and horizontal directions, along with unbonded tendons. Aimed at enhancing transportability and modular assembly in bridge construction, four box girder specimens, including a conventional segmented girder (CSG) and three multi-directionally segmented girders (MDSG), were fabricated and tested under monotonic loading. Unbonded steel bars and tendons were utilized to facilitate both longitudinal and horizontal assembly of the specimens. Experimental results showed that all specimens failed due to flexural compression, with initial cracks in the bottom flange joints, ultimately leading to concrete crushing in the compression zone. MDSG specimens demonstrated load-deflection responses similar to CSG, with joint openings stabilizing at higher loads. Flexural ductility indices reached up to 24.6 in MDSG specimens, surpassing those of CSG, while post-cracking capacity ratios indicated adequate post-cracking resilience. Tendon stress increments showed deviations of 3 %-32 % from analytical predictions, suggesting the influence of tendon slip and joint opening effects, highlighting the need for improved predictive models. The tensile stress in the tendon followed a quadratic relationship with mid-span deflection, which was incorporated into the moment versus curvature analysis simulation. Despite minor discrepancies in curvature predictions, the multi-layer sectional analysis model accurately estimated ultimate moments, with minimal differences from experimental values across all segmental girders. These findings demonstrate that segmental box girders with multi-directional dry joints and unbonded tendons exhibit high flexural ductility, stable joint behavior, and adequate post-cracking load-carrying capacity, confirming their feasibility for modular bridge construction. | Choi, Jin-Seok; Hong, Se-Hee; Lee, Jin-Yong; Kim, Seong-Kyum; Yoon, Young-Soo | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kumoh Natl Inst Technol, Dept Civil Engn, 61 Daehak Ro, Gumi 39177, Gyeongsangbuk, South Korea | Yoon, Young Soo/LYO-5503-2024; Lee, Jin-Yong/AFL-8422-2022 | 57208750094; 57217686181; 59738571000; 36706342900; 7402126768 | skim@kumoh.ac.kr; ysyoon@korea.ac.kr; | ENGINEERING STRUCTURES | ENG STRUCT | 0141-0296 | 1873-7323 | 335 | SCIE | ENGINEERING, CIVIL | 2024 | 6.4 | 9.0 | 0 | 2025-05-07 | 0 | 0 | Modular bridges; Segmental box girder; Prestressed concrete; Dry joint; Unbonded reinforcement | FIBER-REINFORCED CONCRETE; BEAMS; SHEAR; BEHAVIOR; ULTIMATE; STRENGTH; STRESS; MEMBERS | Dry joint; Modular bridges; Prestressed concrete; Segmental box girder; Unbonded reinforcement | Bars (metal); Concrete beams and girders; Concrete bridges; Concrete buildings; Cracks; Deflection (structures); Prestressed beams and girders; Prestressed concrete; Box girder; Bridge constructions; Dry joints; Modular bridge; Modulars; Pre-stressed; Prestressed concrete box girder; Segmental box girder; Unbonded reinforcement; Unbonded tendons; bridge construction; concrete structure; cracking (fracture); curvature; failure mechanism; flexure; loading test; reinforced concrete; segmentation; structural analysis; Box girder bridges | English | 2025 | 2025-07-15 | 10.1016/j.engstruct.2025.120341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Toxicological effects of microplastic fibers from different disposable face masks on Caenorhabditis elegans | During the COVID-19 pandemic, the widespread use of disposable face masks generated substantial waste, much of which ends up in terrestrial environments. However, the impact of this discarded material on soil ecosystems remains poorly understood. This study investigated the toxicological effects of microplastics derived from three types of disposable face masks (KF94, medical, and particulate respirator) and a polypropylene reference material on the soil nematode Caenorhabditis elegans (C. elegans). Exposure to 0.3 % (w/w, microplastic/soil) microplastics from KF94 masks and particulate respirators significantly reduced offspring numbers. Mass spectrometry (MS)-based metabolomic analysis revealed distinct metabolic alterations in C. elegans exposed to microplastics. Both KF94 masks and particulate respirators commonly disrupted the polyamine biosynthesis pathway but exhibited differing impacts on associated metabolites. High-resolution MS analysis of plastic additives extracted from the masks suggested that these differential metabolic changes could be attributed to various additives, including phthalates known to exhibit reproductive toxicity in C. elegans. These findings highlight the potential risk of plastic additives from disposed face masks disrupting soil ecosystems, raising concerns about their long-term environmental impact on soil health and biodiversity. | Kim, Jonghyun; Kim, Shin Woong; Waldman, Walter W.; Bredendiek, Felix; Son, Seungwoo; Kim, Sunghwan; Parr, Maria K.; Rillig, Matthias C.; Kim, Tae-Young | Gwangju Inst Sci & Technol, Coll Engn, Dept Environm & Energy Engn, Gwangju 61005, South Korea; Free Univ Berlin, Inst Biol, D-14195 Berlin, Germany; Berlin Brandenburg Inst Adv Biodivers Res, D-14195 Berlin, Germany; Univ Fed Sao Carlos, Sci & Technol Ctr Sustainabil, BR-18052780 Sorocaba, SP, Brazil; Free Univ Berlin, Inst Pharm, D-14195 Berlin, Germany; Free Univ Berlin, Dept Biol Chem & Pharm, Core Facil BioSupraMol, D-14195 Berlin, Germany; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Mass Spectrometry Convergence Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea; Korea Inst Toxicol, Ctr Ecotoxicol & Environm Future Res, Jinju 52834, South Korea | Kim, Shin/AAN-2542-2020; Waldman, Walter/F-4941-2010; Rillig, Matthias/AAE-6980-2019 | 57209655105; 59715361000; 59762193000; 57212761257; 57206473214; 57203772967; 57208558509; 7004185813; 57049826900 | rillig@zedat.fu-berlin.de; kimtaeyoung@gist.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 300 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 0 | 2025-06-11 | 0 | 0 | mask; microplastics; Caenorhabditis elegans; metabolomics; plastic additive | OXIDATIVE STRESS; TOXICITY; ADDITIVES; NEMATODES; CHEMICALS | Caenorhabditis elegans; mask; metabolomics; microplastics; plastic additive | Animals; Caenorhabditis elegans; COVID-19; Masks; Microplastics; Soil Pollutants; microplastic; polyamine; polypropylene; microplastic; additive; mass spectrometry; metabolite; nematode; plastic; pollution exposure; toxicology; Article; biodiversity; biosynthesis; Caenorhabditis elegans; false discovery rate; high performance liquid chromatography; liquid chromatography-mass spectrometry; mass spectrometry; metabolite; microbial community; nematode; nonhuman; soil analysis; toxicology; adverse event; animal; coronavirus disease 2019; drug effect; mask; prevention and control; soil pollutant; toxicity | English | 2025 | 2025-07-15 | 10.1016/j.ecoenv.2025.118451 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tunable chemotherapy release using biocompatible fatty acid-modified ethyl cellulose nanofibers | Localized stimuli-responsive delivery systems for chemotherapy drugs have the potential to revolutionize therapeutic outcomes by offering greater selectivity, thereby reducing systemic side effects and bolstering patient benefits. In this work, ethyl cellulose (EC) nanofibers were prepared using electrospinning, encapsulating both doxorubicin HCl (DOX) and Rhodamine B (RhB) as representative hydrophilic chemotherapy and model drugs, respectively, and lauric acid (LA) as a biocompatible phase change material (PCM). In vitro release profiles demonstrated a distinct temperature-dependent release pattern: a noteworthy 27 % increase in release for DOX at pH 7.4 at 40 degrees C compared to 37 degrees C after 96 h Additionally, the release mechanism of DOX showcased pronounced pH sensitivity, evidenced by an increase of 41 % in release after 96 h at pH 4 when the temperature was increased from 37 degrees C to 40 degrees C, combined with a noticeable reduction of burst release. Furthermore, cytotoxicity assay indicated the prolonged efficacy of the DOX-embedded nanofibers, underscoring their therapeutic potential. Advanced analytical techniques, such as DSC, XRD, and FTIR, revealed an amorphous state of the drugs and a harmonious PCM integration. Our EC drug delivery system (DDS) demonstrated potential for targeted, stimuli-responsive DOX release, which could revolutionize its traditional administration, particularly in postsurgical scenarios to prevent tumor recurrence. | Wildy, Michael; Hao, Qiangjun; Wei, Wanying; Nguyen, Duc Huy; Xu, Kai; Schossig, John; Hu, Xiao; Salas-de la Cruz, David; Hyun, Dong Choon; Wang, Zhihong; Lu, Ping | Rowan Univ, Dept Chem & Biochem, Glassboro, NJ 08028 USA; Rowan Univ, Dept Phys & Astron, Glassboro, NJ 08028 USA; Rutgers Univ Camden, Ctr Computat & Integrat Biol, Dept Chem, 315 Penn St, Camden, NJ 08102 USA; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea | ; Duc Huy, Nguyen/B-9849-2017 | 57846873700; 58862783300; 57219923324; 58609181700; 58419841800; 58420501800; 55549803100; 35410228500; 59540398900; 37025271200; 57195511292 | lup@rowan.edu; | CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS | CARBOHYDR POLYM TECH | 2666-8939 | 9 | ESCI | CHEMISTRY, APPLIED;POLYMER SCIENCE | 2024 | 6.5 | 9.0 | 0 | 2025-05-07 | 1 | 1 | Stimuli-responsive delivery; Ethyl cellulose nanofibers; Doxorubicin; Lauric acid; Phase change material; Electrospinning | DRUG-DELIVERY; ELECTROSPUN NANOFIBERS; DOXORUBICIN RELEASE; MATS; POLYLACTIDE; FABRICATION; PH | Doxorubicin; Electrospinning; Ethyl cellulose nanofibers; Lauric acid; Phase change material; Stimuli-responsive delivery | English | 2025 | 2025-03 | 10.1016/j.carpta.2025.100670 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Unveiling the Complexity of Designers' Intention to Use Generative AI in Corporate Product Design: A Grounded Theory and fsQCA | While generative artificial intelligence (Gen AI) is accelerating digital transformation and innovation in corporate product design (CPD), limited research has explored how designers adopt this technology. This study aims to identify the key factors and causal configurations that influence designers' intentions to adopt Gen AI in CPD. This study involved 327 in-service designers as participants, employed semi-structured interviews and a questionnaire to collect data, and applied the grounded theory and fsQCA to analyze the data. The findings indicate the following: (1) Personal innovativeness, AI technological anxiety, perceived usefulness, task-technology fit, perceived risk, social influence, and organizational support are the key factors influencing designers' adoption of Gen AI. (2) None of these factors constitute a necessary condition for designers to adopt Gen AI. (3) High adoption intention results from the interaction of multiple factors, which can be categorized into three driving logics: "task demand-driven", "organizational environment-driven", and "individual characteristics-driven". It is recommended that corporate managers establish an AI training framework, foster a supportive organizational environment, and implement tailored strategies to facilitate the integration of new technologies. This study clarifies the factors influencing designers' adoption of Gen AI in CPD and provides a framework for companies to effectively integrate AI systems into product design. | Li, He; Liu, Yuqing; Guo, Qihan; Shi, Mingxi; Zhang, Peng; Kim, Seongnyeon | Kyungpook Natl Univ, Sch Arts, Daegu 37224, South Korea; Wuhan Univ Technol, Sch Art & Design, Wuhan 430070, Peoples R China | 59347881400; 59754067000; 59170865600; 59170301700; 58247542600; 59753331700 | tayon13@knu.ac.kr; liuyuqing091@gmail.com; 349256@whut.edu.cn; smx0609@knu.ac.kr; 2021327350@knu.ac.kr; kimsn@knu.ac.kr; | SYSTEMS | SYSTEMS-BASEL | 2079-8954 | 13 | 4 | SSCI | SOCIAL SCIENCES, INTERDISCIPLINARY | 2024 | 3.1 | 9.0 | 0 | 2025-05-07 | 0 | 0 | corporate product design; generative AI; adoption intention; grounded theory; fsQCA | MIXED METHODS; INFORMATION-TECHNOLOGY; ACCEPTANCE; ADOPTION; METHODOLOGY; PERSPECTIVE; TELEPHONE; THINKING; MODEL | adoption intention; corporate product design; fsQCA; generative AI; grounded theory | Intellectual property core; Adoption intention; Corporate product design; Corporates; Digital transformation; FsQCA; Generative AI; Grounded theory; Intention to use; Key factors; Organisational; Integrated circuit layout | English | 2025 | 2025-04-09 | 10.3390/systems13040275 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Deep Learning Model Using Stool Pictures for Predicting Endoscopic Mucosal Inflammation in Patients With Ulcerative Colitis | INTRODUCTION:Stool characteristics may change depending on the endoscopic activity of ulcerative colitis (UC). We developed a deep learning model using stool photographs of patients with UC (DLSUC) to predict endoscopic mucosal inflammation.METHODS:This was a prospective multicenter study conducted in 6 tertiary referral hospitals. Patients scheduled to undergo endoscopy for mucosal inflammation monitoring were asked to take photographs of their stool using smartphones within 1 week before the day of endoscopy. DLSUC was developed using 2,161 stool pictures from 306 patients and tested on 1,047 stool images from 126 patients. The UC endoscopic index of severity was used to define endoscopic activity. The performance of DLSUC in endoscopic activity prediction was compared with that of fecal calprotectin (Fcal).RESULTS:The area under the receiver operating characteristic curve (AUC) of DLSUC for predicting endoscopic activity was 0.801 (95% confidence interval [CI] 0.717-0.873), which was not statistically different from the AUC of Fcal (0.837 [95% CI, 0.767-0.899, DeLong P = 0.458]). When rectal-sparing cases (23/126, 18.2%) were excluded, the AUC of DLSUC increased to 0.849 (95% CI, 0.760-0.919). The accuracy, sensitivity, and specificity of DLSUC in predicting endoscopic activity were 0.746, 0.662, and 0.877 in all patients and 0.845, 0.745, and 0.958 in patients without rectal sparing, respectively. Active patients classified by DLSUC were more likely to experience disease relapse during a median 8-month follow-up (log-rank test, P = 0.002).DISCUSSION:DLSUC demonstrated a good discriminating power similar to that of Fcal in predicting endoscopic activity with improved accuracy in patients without rectal sparing. This study implies that stool photographs are a useful monitoring tool for typical UC. | Lee, Jung Won; Woo, Dongwon; Kim, Kyeong Ok; Kim, Eun Soo; Kim, Sung Kook; Lee, Hyun Seok; Kang, Ben; Lee, Yoo Jin; Kim, Jeongseok; Jang, Byung Ik; Kim, Eun Young; Jo, Hyeong Ho; Chung, Yun Jin; Ryu, Hanjun; Park, Soo-Kyung; Park, Dong-Il; Yu, Hosang; Jeong, Sungmoon | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Sch Med, Daegu, South Korea; Mt Sinai Hosp, Zane Cohen Ctr Digest Dis, Toronto, ON, Canada; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Inflammatory Bowel Dis Ctr, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; AICU Corp, Daegu, South Korea | Jo, Hyeong Ho/LFU-2981-2024; Kim, Eun-young/AAI-8613-2020; Kim, Sang/J-5398-2012; Kim, You Sun/B-2881-2015; Kim, Sun/C-2026-2011; 康, 奔/JMQ-0812-2023; Lee, Yoojin/AAB-9799-2022; Lee, Jung Won/KHZ-4320-2024 | 59235675700; 58738349500; 53363798100; 57203086704; 34770060400; 36647886100; 57194823199; 55531365900; 55636277000; 22953491400; 58889004100; 57544016800; 57199411938; 57224354996; 57221712520; 56524839700; 57205199961; 23100090400 | jwlee0966@naver.com; woodongwon23@gmail.com; cello7727@naver.com; dandy813@hanmail.net; knuhkim@gmail.com; mdleehs@hanmail.net; benkang@knu.ac.kr; doctorlyj@naver.com; nobeldoc@gmail.com; jbi@medical.yu.ac.kr; kimey@cu.ac.kr; johh0205@naver.com; gooddr76@gmail.com; usrhj@naver.com; skparkmd@gmail.com; dipark1967@gmail.com; youhs4554@gmail.com; jeongsm@knu.ac.kr; | AMERICAN JOURNAL OF GASTROENTEROLOGY | AM J GASTROENTEROL | 0002-9270 | 1572-0241 | 120 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 7.6 | 9.2 | 0 | 2025-05-07 | 2 | 3 | ulcerative colitis; stool photograph; deep learning; endoscopic activity | C-REACTIVE PROTEIN; FECAL CALPROTECTIN; BOWEL-DISEASE; VALIDATION; SEVERITY; OUTCOMES; INDEX; SCORE | deep learning; endoscopic activity; stool photograph; ulcerative colitis | Adult; Aged; Colitis, Ulcerative; Colonoscopy; Deep Learning; Feces; Female; Humans; Intestinal Mucosa; Leukocyte L1 Antigen Complex; Male; Middle Aged; Photography; Predictive Value of Tests; Prospective Studies; ROC Curve; Severity of Illness Index; albumin; C reactive protein; calgranulin; corticosteroid; hemoglobin; mercaptopurine; tofacitinib; ustekinumab; vedolizumab; calgranulin; adult; algorithm; area under the curve; Article; clinical outcome; colonoscopy; deep learning; diagnostic accuracy; diagnostic test accuracy study; disease activity; disease duration; endoscopist; endoscopy; feces; female; follow up; human; image analysis; imaging; intestine preparation; Kaplan Meier method; major clinical study; male; middle aged; model; mucosa inflammation; photography; predictive value; prevalence; proportional hazards model; prospective study; receiver operating characteristic; rectum hemorrhage; relapse; scoring system; sensitivity and specificity; sigmoidoscopy; tertiary care center; ulcerative colitis; ulcerative colitis endoscopic index of severity; aged; chemistry; clinical trial; colonoscopy; diagnostic imaging; intestine mucosa; multicenter study; pathology; procedures; severity of illness index | English | 2025 | 2025-01 | 10.14309/ajg.0000000000002978 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Estimation and Inference of Quantile Spatially Varying Coefficient Models Over Complicated Domains | This article presents a flexible quantile spatially varying coefficient model (QSVCM) for the regression analysis of spatial data. The proposed model enables researchers to assess the dependence of conditional quantiles of the response variable on covariates while accounting for spatial nonstationarity. Our approach facilitates learning and interpreting heterogeneity in spatial data distributed over complex or irregular domains. We introduce a quantile regression method that uses bivariate penalized splines in triangulation to estimate unknown functional coefficients. We establish the (Formula presented.) convergence of the proposed estimators, demonstrating their optimal convergence rate under certain regularity conditions. An efficient optimization algorithm is developed using the alternating direction method of multipliers (ADMM). We develop wild residual bootstrap-based pointwise confidence intervals for the QSVCM quantile coefficients. Furthermore, we construct reliable conformal prediction intervals for the response variable using the proposed QSVCM. Simulation studies show the remarkable performance of the proposed methods. Lastly, we illustrate the practical applicability of our methods by analyzing the mortality dataset and the supplementary particulate matter (PM) dataset in the United States. Supplementary materials for this article are available online, including a standardized description of the materials available for reproducing the work. © 2025 American Statistical Association. | Kim, Myungjin; Wang, Li; Wang, Huixia Judy | Department of Statistics, KNU G-LAMP Project Group, KNU Institute of Basic Sciences, Kyungpook National University, Daegu, South Korea; Department of Statistics, George Mason University, Fairfax, VA, United States; Department of Statistics, The George Washington University, Washington, DC, United States | 57216929620; 25123309200; 16044332500 | lwang41@gmu.edu; | Journal of the American Statistical Association | J AM STAT ASSOC | 0162-1459 | 1537-274X | SCIE | STATISTICS & PROBABILITY | 2024 | 3 | 9.3 | 0 | Alternating direction method of multiplier; Bivariate penalized spline; Conformal prediction; Nonparametric quantile regression; Triangulation | English | Article in press | 2025 | 10.1080/01621459.2025.2480867 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | Meeting Abstract | IgG Podocyte Dusting in Primary and Secondary Minimal Change Disease and Association with Electron Microscopy Features | Leong, Matthew; Lee, Chen Yu Jamie; Yamashita, Michifumi; Kiyozawa, Daisuke; Han, Man Hoon; Nast, Cynthia | Cedars Sinai Med Ctr, Los Angeles, CA USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea | LABORATORY INVESTIGATION | LAB INVEST | 0023-6837 | 1530-0307 | 105 | 3 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PATHOLOGY | 2024 | 4.2 | 9.4 | 0 | English | 2025 | 2025-03 | 10.1016/j.labinv.2024.103724 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Meeting Abstract | Immunohistochemical Evaluation of Predictive Biomarkers to Targeted Therapies in Poorly Cohesive Carcinoma | Kim, Moonsik; Byun, Jungsup; Lee, Eunyeong; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | LABORATORY INVESTIGATION | LAB INVEST | 0023-6837 | 1530-0307 | 105 | 3 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PATHOLOGY | 2024 | 4.2 | 9.4 | 0 | English | 2025 | 2025-03 | 10.1016/j.labinv.2024.102854 | 바로가기 | 바로가기 | 바로가기 |
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