2021 연구성과 (40 / 281)

※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Designed fabrication of sulfide-rich bi-metallic-assembled MXene layered sheets with dramatically enhanced photocatalytic performance for Rhodamine B removal ⓘ Herein, a two-step hydrothermal treatment was used to synthesize a novel hybrid photocatalyst with sulfide-rich layered double hydroxides intercalated MXene for the degradation of rhodamine B (RhB). The fabricated NiCo2S4 on MXene (denoted as NCS@MX) photocatalyst showed higher catalytic activity and degraded RhB to approximately approximate to 100% within 20 min under visible light irradiation. The optical response and recombination rate used increased the separation efficiency of photoinduced eand h+ by NCS@MX, thus enhancing the photocatalytic degradation of RhB. The (OH)-O-center dot and O-center dot(2)- radicals were non-toxic by-products of the NCS@MX system for the mineralization of organic pollutants. Furthermore, NCS@MX exhibited great photo-stability in five repetitive runs for the degradation of RhB with a minimal drop on catalytic activity. Possible oxidative pathways of RhB and the reaction intermediates were observed by liquid chromatography-mass spectrometry (LC-MS). The pollutant was primarily oxidized into non-toxic products such as H2O, CO2, and few inorganic species. Therefore, NCS@MX is expected to have prospects for applications in wastewater management considering its environmental friendliness, low-cost, and non-toxic by-products production. ⓘ Vigneshwaran, Sivakumar; Park, Chang Min; Meenakshi, Sankaran ⓘ Deemed Univ, Gandhigram Rural Inst, Dept Chem, Dindigul 624302, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Vigneshwaran, Siva kumar/IST-9536-2023; Park, Chang Min/CAA-8506-2022; Vigneshwaran, Sivakumar/AAE-6278-2022; Meenakshi, Sankaran/AAF-5748-2020 ⓘ 57207105576; 57209588953; 58099005900 ⓘ cmpark@knu.ac.kr;sankaranmeenakshi2014@gmail.com; ⓘ SEPARATION AND PURIFICATION TECHNOLOGY ⓘ SEP PURIF TECHNOL ⓘ 1383-5866 1873-3794 258 SCIE ENGINEERING, CHEMICAL ⓘ 2021 9.136 9.4 3.18 2025-07-30 ⓘ 63 67 Photocatalyst; MXene; NiCo2S4; Rhodamine B; Oxidation ⓘ ⓘ MXene; NiCo<sub>2</sub>S<sub>4</sub>; Oxidation; Photocatalyst; Rhodamine B ⓘ Catalyst activity; Cobalt compounds; Fabrication; Liquid chromatography; Mass spectrometry; Nickel compounds; Organic pollutants; Photodegradation; Reaction intermediates; Rhodium compounds; Sulfur compounds; Environmental friendliness; Hydrothermal treatments; Layered double hydroxides; Liquid chromatography-Mass spectrometry; Photo catalytic degradation; Photocatalytic performance; Separation efficiency; Visible-light irradiation; Rhodamine B ⓘ English 2021 2021-03-01 10.1016/j.seppur.2020.118003 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Exogenous Melatonin mediates the regulation of endogenous nitric oxide in Glycine max L. to reduce effects of drought stress ⓘ Drought stress retards plant growth and yield. Melatonin and nitric oxide (NO) have demonstrated their potential role against abiotic stresses; however, the underlying molecular mechanism by which they interact and extend drought stress tolerance has not been fully elucidated. Herein, the current study was performed to establish the optimum beneficial concentration of MT and NO in combating drought stress and later understand its responses at biochemical, and molecular levels. Results showed exogenous MT, and sodium nitroprusside (SNP as NO donor) have counteracted drought-induced growth inhibition of soybean (Glycine max L.) by increasing plant biomass, photosynthesis efficiency and water content and reducing reactive oxygen species accumulation. MT and NO treatments showed reduced lipid peroxidation and improved defense responses via significantly higher antioxidant enzyme activities than control during drought. Surprisingly, endogenous abscisic acid (ABA) contents and gene expression of its synthesis and ABA-responsive proteins and their promoters were significantly decreased in drought by MT + NO. This was coupled with an increase in endogenous MT levels. In endo-NO regulations, S-nitrosoglutathione was increased, but L-NAME (NO inhibitor) and cPTIO (NO scavenger) decreased the S-nitrosothiol (SNO) contents, which was followed by the increased expression of NO-synthesisrelated-genes by MT + NO. Interestingly, MT + NO-induced drought stress tolerance was coupled with increased expression of transcription factors such as GmWRKY27 and GmMYB174. Conclusively, the physiological, antioxidant, and molecular analysis showed that MT triggers downregulated NO accumulation, promoting tolerance against drought stress. ⓘ Imran, Muhammad; Shazad, Raheem; Bilal, Saqib; Imran, Qari Muhammad; Khan, Murtaza; Kang, Sang-Mo; Khan, Abdul Latif; Yun, Byung-Wook; Lee, In-Jung ⓘ Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Univ Haripur, Dept Hort, Haripur 22620, Pakistan; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden ⓘ Imran, Qari Muhammad/ABG-6074-2022; Imran, Muhammad/AFL-6590-2022; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Shahzad, Raheem/JDM-3580-2023; Khan, Abdul/B-1005-2010 ⓘ 58282433800; 57223868849; 57031617400; 55849263700; 57207990116; 56189696900; 26639372800; 8245123600; 16425830900 ⓘ bwyun@knu.ac.kr;ijlee@knu.ac.kr; ⓘ ENVIRONMENTAL AND EXPERIMENTAL BOTANY ⓘ ENVIRON EXP BOT ⓘ 0098-8472 1873-7307 188 SCIE ENVIRONMENTAL SCIENCES;PLANT SCIENCES ⓘ 2021 6.028 9.4 5.13 2025-07-30 ⓘ 52 57 Melatonin; Nitric oxide; Drought stress; Abscisic acid; Transcription factors; Gene expression ⓘ SPHINGOMONAS SP LK11; ABSCISIC-ACID; TRANSCRIPTION FACTORS; OXIDATIVE STRESS; 9-CIS-EPOXYCAROTENOID DIOXYGENASE; ANTIOXIDANT SYSTEMS; ENHANCED TOLERANCE; HYDROGEN-PEROXIDE; ADVENTITIOUS-ROOT; S-NITROSYLATION ⓘ Abscisic acid; Drought stress; Gene expression; Melatonin; Nitric oxide; Transcription factors ⓘ Glycine max; antioxidant; climate effect; crop yield; drought stress; gene expression; growth; induced response; molecular analysis; nitric oxide; pigment; soybean ⓘ English 2021 2021-08 10.1016/j.envexpbot.2021.104511 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Germplasm evaluation of Kenaf (Hibiscus cannabinus) for alternative biomass for cellulosic ethanol production ⓘ Kenaf (Hibiscus cannabinus) is an annual fiber crop grown mainly in India and China. This crop is becoming a new bio-based energy source because of its fast growth rate, excellent CO2 absorption ability, and large productivity per unit area. In this study, we evaluated 10 different cultivars of kenaf for their potential as biomass for cellulosic ethanol production. First, kenaf samples were hydrolyzed using dilute sulfuric acid, which is the most simple and cost-effective pretreatment method. Next, simultaneous saccharification and fermentation (SSF) of the hydrolysates were performed by wild-type and engineered xylose-fermenting yeast strains. The results of compositional analysis of the biomass, the hydrolysates, and the fermented products suggested that ethanol yield and productivity were significantly affected by a type of kenaf cultivars, which was not predictable based on the biomass compositions. Also, the ethanol production was maximized when the xylose fraction was utilized by engineered yeast under the control of pH to avoid acetate inhibition. Considering the sugar compositions and their fermentability, kenaf can be a promising energy-dedicated crop for cellulosic ethanol production. ⓘ Park, Heeyoung; Park, Sang Un; Jang, Byeong-Kwan; Lee, Jeong Jae; Chung, Yong Suk ⓘ Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Chungnam Natl Univ, Dept Crop Sci, Daejeon, South Korea; Chungnam Natl Univ, Dept Anim Sci & Biotechnol, Daejeon 34134, South Korea; Jeju Natl Univ, Dept Plant Resources & Environm, Jeju 63243, South Korea ⓘ Chung, Yong/V-6909-2019; Jang, Byeong Kwan/IQV-9121-2023 ⓘ 57211334915; 57783497100; 57220054462; 55915465100; 36983850100 ⓘ leejeongjae@cnu.ac.kr;yschung@jejunu.ac.kr; ⓘ GLOBAL CHANGE BIOLOGY BIOENERGY ⓘ GCB BIOENERGY ⓘ 1757-1693 1757-1707 13 1 SCIE AGRONOMY;ENERGY & FUELS ⓘ 2021 5.957 9.4 0.75 2025-07-30 ⓘ 13 13 lignocellulosic biomass; Saccharomyces cerevisiae; xylose fermentation ⓘ LIGNOCELLULOSIC BIOMASS; XYLOSE FERMENTATION; ACETIC-ACID; FIBER; COMPOSITES; L. ⓘ lignocellulosic biomass; Saccharomyces cerevisiae; xylose fermentation ⓘ Hibiscus cannabinus; Saccharomyces cerevisiae; Bioethanol; Biomass; Cellulosic ethanol; Cost effectiveness; Crops; Ethanol; Growth rate; Hemp; Productivity; Saccharification; Yeast; Biomass compositions; Compositional analysis; Dilute sulfuric acid; Germplasm evaluation; Hibiscus cannabinus; Pretreatment methods; Simultaneous saccharification and fermentation; Xylose-fermenting yeasts; annual plant; biomass; cellulose; ethanol; fermentation; germplasm; herb; lignin; yeast; Sugar industry ⓘ English 2021 2021-01 10.1111/gcbb.12758 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Photocatalytic degradation of levofloxacin by a novel Sm6WO12/g-C3N4 heterojunction: Performance, mechanism and degradation pathways ⓘ Recent year pharmaceutical pollutants have highly detected in environment, because they do not completely mineralized and remain toxic. Semiconductor photocatalyst materials have well recognized as promising technology for environmental pollutants removal in the presence of visible light. In this work, a novel binary Sm6WO12 modified g-C3N4 nanosheets heterojunction was fabricated via simple facile method. The morphology of the newly prepared g-C3N4 and Sm6WO12 was confirmed as nanosheets and nanorods by using microscopy techniques. The sequence of characterization results verified that the Sm6WO12/g-C3N4 synergistically integrate the excellent properties and successful construction of hetero-structure between the Sm6WO12 and g-C3N4. The Sm6WO12/g-C3N4 nanocomposite heterojunction catalyst shows higher photocatalytic efficiency towards degrading pharmaceutical pollutant levofloxacin compared to individual g-C3N4 and Sm6WO12 photocatalyst. The results indicate that about 90.8% of levofloxacin was degraded after 70 min in the presence of Sm6WO12/g-C3N4 nanocomposite. Through radical trapping experiments, O-2(center dot-) and (OH)-O-center dot were proved to be the leading reactive oxidative species contributing to degradation of levofloxacin. Possible photodegradation pathways were proposed based on the detected intermediate products and transformation products. Furthermore, the synthesized Sm6WO12/g-C3N4 heterojunction demonstrated excellent reusability and stability without of loss of photo catalytic activity. Favorably, this study might provide a deep insight into mechanism and possible degradation pathways of levofloxacin by Sm6WO12 modified g-C3N4 heterojunction photocatalyst. ⓘ Prabavathi, Seenivasan Laskhmi; Saravanakumar, Karunamoorthy; Park, Chang Min; Muthuraj, Velluchamy ⓘ VHN Senthikumara Nadar Coll Autonomous, Dept Chem, Virudunagar 626001, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ; Karunamoorthy, Saravanakumar/Q-2005-2016; Park, Chang Min/CAA-8506-2022; Veluchamy, Muthuraj/AGO-8278-2022 ⓘ 57200601983; 57223020778; 57209588953; 57203214600 ⓘ muthuraj75@gmail.com; ⓘ SEPARATION AND PURIFICATION TECHNOLOGY ⓘ SEP PURIF TECHNOL ⓘ 1383-5866 1873-3794 257 SCIE ENGINEERING, CHEMICAL ⓘ 2021 9.136 9.4 5.13 2025-07-30 ⓘ 113 118 Sm6WO12/g-C3N4 nanocomposite; Levofloxacin; Photocatalysis; Heterojuction formation ⓘ ELECTRO-FENTON PROCESS; COMPOSITE PHOTOCATALYSTS; ANTIBIOTIC LEVOFLOXACIN; HYDROTHERMAL SYNTHESIS; EFFICIENT DEGRADATION; G-C3N4; CONSTRUCTION; NANOCOMPOSITES; IDENTIFICATION; MICROSPHERES ⓘ Heterojuction formation; Levofloxacin; Photocatalysis; Sm<sub>6</sub>WO<sub>12</sub>/g-C<sub>3</sub>N<sub>4</sub> nanocomposite ⓘ Environmental technology; Heterojunctions; Nanocatalysts; Nanocomposites; Nanorods; Nanosheets; Photocatalytic activity; Pollution; Reusability; Environmental pollutants; Microscopy technique; Photo catalytic degradation; Photocatalytic efficiency; Photodegradation pathway; Reactive oxidative species; Semiconductor photocatalyst; Transformation products; Samarium compounds ⓘ English 2021 2021-02-15 10.1016/j.seppur.2020.117985 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An ensemble approach with external archive for multi- and many-objective optimization with adaptive mating mechanism and two-level environmental selection ⓘ Based on mating and environmental selections employed, multi-objective evolutionary algorithms (MOEAs) are classified as Pareto-based, decomposition-based and indicator-based approaches that are associated with their own advantages and disadvantages. To benefit from the advantages of different MOEAs, we propose an ensemble framework (ENMOEA) in which mating and environmental selections of diverse MOEAs are combined. ENMOEA is a single-population competitive ensemble, where resource allocation to individual mating operators is done adaptively. In addition, ENMOEA employs a two-level environmental selection where constituent environmental selection operators are first applied to label solutions as "selected" and "non-selected". Solutions "selected" by most operators are preferred for future evolution. An external archive is employed to facilitate effective usage of function evaluations and achieve a better comprise between convergence and diversity. To demonstrate generality of ENMOEA, we developed two variants: 1) specific case (ENMOEA(5) - combines different Pareto-based MOEAs) and 2) general case (ENMOEA(G) - combines Pareto-based, indicator-based and decomposition-based MOEAs). From simulation results on various test suites (DTLZ, WFG and 16 real-world problems), it is evident that ENMOEA is robust to the parameters of the constituent algorithms. In addition, it is evident that the effectiveness of ensemble improves with the diversity of the constituent algorithms. (C) 2020 Elsevier Inc. All rights reserved. ⓘ Palakonda, Vikas; Mallipeddi, Rammohan; Suganthan, Ponnuthurai Nagaratnam ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu, South Korea; Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore ⓘ Suganthan, Ponnuthurai/A-5023-2011; Mallipeddi, Rammohan/AAL-5306-2020 ⓘ 57193028485; 25639919900; 7003996538 ⓘ vikas.11475@gmail.com;mallipeddi.ram@gmail.com;epnsugan@ntu.edu.sg; ⓘ INFORMATION SCIENCES ⓘ INFORM SCIENCES ⓘ 0020-0255 1872-6291 555 SCIE COMPUTER SCIENCE, INFORMATION SYSTEMS ⓘ 2021 8.233 9.5 1.33 2025-07-30 ⓘ 24 27 Evolutionary computation; Pareto-dominance; Ensemble; Multi-objective optimization; Many-objective optimization ⓘ ⓘ Ensemble; Evolutionary computation; Many-objective optimization; Multi-objective optimization; Pareto-dominance ⓘ Artificial intelligence; Software engineering; Ensemble approaches; Many-objective optimizations; Multi objective evolutionary algorithms; Real-world problem; Selection operators; Evolutionary algorithms ⓘ English 2021 2021-05 10.1016/j.ins.2020.11.040 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Effect of initial microstructure on graphitization behavior of Fe-0.55C-2.3Si steel ⓘ In this study, the effect of the initial microstructure (i.e., ferrite + pearlite or martensite) on the graphitization behavior and microstructural evolution during heat treatment of a hot-rolled medium-carbon, high-silicon steel (Fe-0.55C-2.3Si) is investigated. When a sample consists of ferrite and pearlite, its microstructure gradually changes to ferrite and graphite during heat treatment via the decomposition of pearlite and the formation of graphite particles. In the sample with a martensite microstructure, the phase transformation occurs in the following step: martensite -> ferrite + cementite -> ferrite + graphite. Although the graphitization process of the martensite sample is more complex than that of the ferrite + pearlite sample, the graphitization rate is substantially faster in the former owing to more abundant grain boundaries and triple junctions that act as nucleation sites for graphite. When the initial microstructure changes from ferrite + pearlite to martensite, the graphite completion time significantly reduces from 16 to 2 h at 650 degrees C and from 6 to 0.5 h at 700 degrees C. After complete graphitization, the average size and number density of graphites in the martensite sample are respectively smaller and higher than those in the ferrite + pearlite sample. The rate of hardness decrease (i.e., material softening) during heat treatment is also faster in the martensite sample. These results demonstrate that changing the initial microstructure from ferrite + pearlite to martensite is an effective means to accelerate the graphitization behavior and acquire a graphitized steel with uniformly distributed fine graphite particles. (C) 2021 The Authors. Published by Elsevier B.V. ⓘ Kim, Ye Jin; Park, Sung Hyuk ⓘ Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea ⓘ Park, Sung-Hyuk/AAE-6726-2022 ⓘ 59052467200; 54786002500 ⓘ sh.park@knu.ac.kr; ⓘ JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T ⓘ J MATER RES TECHNOL ⓘ 2238-7854 2214-0697 15 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING ⓘ 2021 6.267 9.5 0.34 2025-07-30 ⓘ 7 8 High-silicon steel; Martensite; Graphitization; Microstructure; Hardness ⓘ LATH MARTENSITE; HEAT-TREATMENT; BORON-NITRIDE; CARBON; KINETICS; FERRITE; CRYSTALLOGRAPHY; SPHEROIDIZATION; TEMPERATURE; NUCLEATION ⓘ Graphitization; Hardness; High-silicon steel; Martensite; Microstructure ⓘ Carbides; Ferrite; Grain boundaries; Graphite; Graphitization; Hardness; Heat treatment; Hot rolling; Microstructure; Pearlite; Pearlitic transformations; Silicon steel; Ferrite-pearlite; Grain boundary junctions; Graphite particles; Graphitization behaviors; Graphitization process; Graphitization rates; High-silicon steel; Hot-rolled; Initial microstructures; Phases transformation; Martensite ⓘ English 2021 2021 (NOV-DEC) 10.1016/j.jmrt.2021.10.071 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Effects of post-heat treatment on microstructure, tensile properties, and bending properties of extruded AZ80 alloy ⓘ This study investigates the effects of post-heat treatments on microstructural characteristics, uniaxial tensile properties, and three-point bending properties of an extruded AZ80 alloy. The as-extruded material (no heat treatment) has a fine recrystallized grain structure containing Mg17Al12 precipitates formed along grain boundaries. During the 10-h 400 degrees C treatment in Ar-SF6 (treatment T4), precipitates fully dissolved into the matrix and grain coarsening occurred with a decrease in the dislocation density. Since the as-extruded material has a higher dislocation density, it exhibited accelerated precipitation behavior during aging; consequently, its peak aging time was shorter than that of the T4 material. The peak-aged, as-extruded material (15-h at 200 degrees C, treatment T5) and peak-aged T4 material (30-h at 200 degrees C, treatment T6), i.e., T5 and T6 materials, respectively, have higher tensile strengths and lower elongations than the as-extruded and T4 materials owing to the presence of more abundant Mg17Al12 precipitates in the former two materials. The tensile yield strengths of the materials are on the order of T5 > T6 > as-extruded > T4. This order is related to the differences in grain size and precipitate amount. The bending yield strengths of the as-extruded, T4, T5, and T6 materials are linearly proportional to their tensile yield strengths and their bending formability linearly increased with the tensile elongation. The relations between the tensile and bending properties of the materials are attributed to the occurrence of macrocracking in the outer region of the bending specimen, where the tensile stress along the longitudinal direction is dominant. (C) 2021 The Author(s). Published by Elsevier B.V. ⓘ Lee, Gyo Myeong; Lee, Jong Un; Park, Sung Hyuk ⓘ Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea ⓘ Park, Sung-Hyuk/AAE-6726-2022 ⓘ 57222810183; 57195056728; 54786002500 ⓘ sh.park@knu.ac.kr; ⓘ JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T ⓘ J MATER RES TECHNOL ⓘ 2238-7854 2214-0697 12 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING ⓘ 2021 6.267 9.5 1.41 2025-07-30 ⓘ 33 33 AZ80 alloy; Heat treatment; Precipitation; Bending; Tensile property ⓘ ROLLED MAGNESIUM ALLOY; AL-ZN ALLOY; MECHANICAL-PROPERTIES; GRAIN-SIZE; YIELD ASYMMETRY; EXTRUSION; BEHAVIOR; PRECIPITATION; DEFORMATION; PRECOMPRESSION ⓘ AZ80 alloy; Bending; Heat treatment; Precipitation; Tensile property ⓘ Aluminum alloys; Bending strength; Binary alloys; Coarsening; Grain boundaries; Grain size and shape; Magnesium alloys; Precipitation (chemical); Tensile strength; Yield stress; As-extruded; As-extruded materials; Az80 alloy; Bending; Bending properties; Peak aged; Post heat-treatment; Post-heat treatment; Property; Tensile yield strength; Heat treatment ⓘ English 2021 2021 (MAY-JUN) 10.1016/j.jmrt.2021.03.046 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ High seebeck coefficient and low thermal conductivity in Bi and In co-doped GeTe thermoelectric material ⓘ Pure GeTe shows inferior thermoelectric performance due to the large carrier concentration caused by the intrinsic high concentration of Ge vacancies. In this study, we report improved thermoelectric performance of Bi and In co-doped GeTe based thermoelectric material where a figure of merit, ZT similar to 1.7 at 623 K was realized through synergetic effect of tuning the carrier concentration, resonant states, and suppression of thermal conduction. In doping induces resonant states in the density of states near the Fermi energy level. Bi sharply reduces lattice thermal conductivity by formation of extensive solid solution point defects. Moreover, Bi and In co-doping decreases the phase transformation temperature to widen the better thermoelectric performance of cubic GeTe at low temperatures. In addition, microstructural characterization showed herringbone structures, high-density of domain boundaries, and twinning. These, together with the point defects, lead to a significantly reduced thermal conductivity. (c) 2021 The Author(s). Published by Elsevier B.V. ⓘ Jeong, Hyerin; Kihoi, Samuel Kimani; Kim, Hyunji; Lee, Ho Seong ⓘ Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ; Kihoi, Samuel Kimani/IUM-8515-2023 ⓘ 57208400603; 57208396874; 57208408040; 55706810400 ⓘ hs.lee@knu.ac.kr; ⓘ JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T ⓘ J MATER RES TECHNOL ⓘ 2238-7854 2214-0697 15 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING ⓘ 2021 6.267 9.5 1.35 2025-07-30 ⓘ 22 23 Thermoelectric; Thermal conductivity; GeTe; Seebeck coefficient; Microstructure; TEM ⓘ BAND CONVERGENCE; PHONON-SCATTERING; PERFORMANCE; FIGURE; MERIT; SB; REALIZATION; ZN ⓘ GeTe; Microstructure; Seebeck coefficient; TEM; Thermal conductivity; Thermoelectric ⓘ Carrier concentration; Germanium compounds; Point defects; Tellurium compounds; Thermal conductivity; Thermoelectric equipment; Transmission electron microscopy; Co-doped; Low thermal conductivity; Resonant state; Synergetic effect; TEM; Thermal conduction; Thermo-Electric materials; Thermoelectric; Thermoelectric material; Thermoelectric performance; Seebeck coefficient ⓘ English 2021 2021 (NOV-DEC) 10.1016/j.jmrt.2021.11.065 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Pr³⁺-doped B2O3-Bi2O3-ZnO-NaF glasses comprising alkali/mixed alkali oxides for potential warm white light generation, blue laser, and E- plus S- plus C-optical bands amplification applications ⓘ For six 1 mol% Pr3+-doped B2O3-Bi2O3-ZnO-NaF glasses consisting of single and mixed alkali oxides, optical absorption and visible and near-infrared (NIR) luminescence traits including visible fluorescence decay times were investigated. Judd-Ofelt (J-O) analysis from absorption spectra was performed to calculate J-O parameters Omega(lambda)(lambda = 2, 4, 6) by including and omitting H-3(4) -> P-3(2) transition. Utilizing Omega(2), Omega(4), and Omega(6) values and refractive indices, radiative transition probabilities (A(R)), branching ratios (beta(R)), and radiative lifetimes for all Pr3+ ion's luminescent levels were estimated. For observed intense blue fluorescence band upon 443 nm optical pumping, various parameters considered in designing visible laser systems were evaluated. Pr3+ : Na + K ions comprising glass possesses large spectroscopic quality factor, high A(R) and beta(R), large stimulated emission cross-section (sigma(em)), high quantum efficiency, large gain bandwidth, and significant optical gain for P-3(0) -> H-3(4) transition for a potential blue lasing action among all samples. Further, Commission Internationale de l'eclairage (CIE) coordinates, correlated color temperature (CCT), color rendering index, and luminous efficiency of radiation were derived from visible luminescence spectra and deduced CIE and CCT values represent the neutral or warm white light region. Upon H-3(4) -> P-3(2) excitation, NIR luminescence spectra show P-3(1) + I-1(6) -> (1)G(4), D-1(2) -> F-3(4), and D-1(2) -> (1)G(4) transitions in which broadband (D-1(2) -> (1)G(4)) at 1.3-1.65 mu m range with effective bandwidth similar to 157 nm was obtained for Pr3+ : Na + K ions constituting glass with high A(R) (1938 s(-1)), moderate beta(R) (26%), and large sigma(em) (2.64 x 10(-20) cm(2)) at 1.472 mu m, and its gain profile covers the E-+S-+C-optical communication bands' range for effective broadband amplification operation. (C) 2021 The Author(s). Published by Elsevier B.V. ⓘ Lakshminarayana, G.; Meza-Rocha, A. N.; Soriano-Romero, O.; Huerta, E. F.; Caldino, U.; Lira, A.; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon ⓘ Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Benemerita Univ Autonoma Puebla, CONACYT, Postgrad Fis Aplicada, Fac Ciencias Fisicomatemat, Av San Claudio & Av 18 Sur, Puebla 72570, Pue, Mexico; Benemerita Univ Autonoma Puebla, Fac Ciencias Fisicomatemat, Postgrad Fis Aplicada, Av San Claudio & Av 18 Sur, Puebla 72570, Pue, Mexico; Univ Autonoma Metropolitana Iztapalapa, Dept Fis, POB 55-534, Mexico City 09340, DF, Mexico; Univ Autonoma Estado Mexico, Fac Ciencias, Dept Fis, Toluca 50000, Mexico; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy, 1370 Sangyeok Dong, Daegu 702701, South Korea; Hanyang Univ, Dept Mech Engn, BK21 FOUR ERICA, ACE Ctr, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea ⓘ LIRA, ALICIA/O-6173-2015; Huerta, Evelyn/GVU-8813-2022; Gandham, Lakshminarayana/AAU-6162-2020; Lira, Alicia/M-4722-2019 ⓘ 57194637883; 37063511900; 57201460286; 36650789500; 56110056100; 6603757680; 56605563300; 56449838900; 55717001200 ⓘ gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; ⓘ JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T ⓘ J MATER RES TECHNOL ⓘ 2238-7854 2214-0697 13 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING ⓘ 2021 6.267 9.5 1.21 2025-07-30 ⓘ 20 22 B2O3-rich glasses; Pr3+; Judd-Ofelt analysis; Luminous efficiency of radiation; Near-infrared emission; E- plus S- plus C optical bands amplifier ⓘ JUDD-OFELT THEORY; UP-CONVERSION LUMINESCENCE; DOPED PHOSPHATE-GLASSES; SPECTROSCOPIC PROPERTIES; PR3+ IONS; EMISSION PROPERTIES; LUMINOUS EFFICACY; TELLURITE GLASSES; ABSORPTION; PHOTOLUMINESCENCE ⓘ B<sub>2</sub>O<sub>3</sub>-rich glasses; E-+S-+C-optical bands amplifier; Judd–Ofelt analysis; Luminous efficiency of radiation; Near-infrared emission; Pr<sup>3+</sup> ⓘ Bismuth compounds; Efficiency; Fluorescence; II-VI semiconductors; Infrared devices; Ions; Light absorption; Quality control; Refractive index; Sodium compounds; Zinc oxide; B$-2$/O$-3$; B2O3-rich glass; Bi$-2$/O$-3$; E-+S-+C-optical band amplifier; Judd-ofelt analysis; Luminoi efficiency of radiation; Near-infrared emissions; Optical-; Pr3+; ZnO; Glass ⓘ English 2021 2021 (JUL-AUG) 10.1016/j.jmrt.2021.06.037 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Spatial Distribution Patterns of Eurasian Otter (Lutra Lutra) in Association with Environmental Factors Unravelled by Machine Learning and Diffusion Kernel Method ⓘ In South Korea, the endangered Eurasian otter (Lutra lutra) populations have been recovered throughout the country. To examine the status of otter populations, we monitored spraint densities at 250 similar to 355 sites annually from 2014 to 2017 in the Nakdong River basin. The diffusion kernel method was applied to both binary and continuous spraint data. Two geographical populations were identified: northern and southern populations. The northern population continuously increased over a broad area from north to south during the study period. In contrast, the southern population narrowly dispersed, limited by its location in an industrial area. The spatial self-organizing map (Geo-SOM) revealed associations between spraint densities and environmental factors by correlating the geographic locations of the sampling sites. Both populations were negatively affected by anthropogenic factors, including proximity to factories and human population density. However, cumulative association of all environmental factors, including landscape, food sources, and anthropogenic factors, were noted in 2016 after which otter populations fully recovered. Population development stabilized while exhibiting an overall high association with environmental factors. The results of the diffusion kernel method and data variation according to the Geo-SOM consistently presented substantial change in population dispersal (i.e. the merge of two subpopulations, and complete associations between spraint and environmental factors). The combination of the diffusion kernel method and Geo-SOM was effective in portraying temporal changes in population states in association with environmental factors based on spraint data in the last phase of full recovery. ⓘ Hong, S.; Chon, T-S; Joo, G. J. ⓘ Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kangwon Natl Univ, Coll Forest & Environm Sci, Dept Forest Environm Protect, Chunchon 25931, South Korea; Ecol & Future Res Assoc, Busan 46228, South Korea; Pusan Natl Univ, Dept Biol Sci, Busan 46241, South Korea ⓘ Hong, Sungwon/K-2809-2019 ⓘ 56431586600; 6701748723; 7006364592 ⓘ tschon.chon@gmail.com;gjjoo@pusan.ac.kr; ⓘ JOURNAL OF ENVIRONMENTAL INFORMATICS ⓘ J ENVIRON INFORM ⓘ 1726-2135 1684-8799 37 2 SCIE ENVIRONMENTAL SCIENCES ⓘ 2021 10.22 9.5 0.53 2025-07-30 ⓘ 10 10 Dispersal; recovery; spraints; habitat preference; conservation; Republic of Korea ⓘ HOME-RANGE; POPULATIONS; DENSITY; CONSERVATION; SIZE; ESTIMATORS; RECOVERY; QUALITY ⓘ Conservation; Dispersal; Habitat preference; Recovery; Republic of Korea; Spraints ⓘ Lutra lutra ⓘ English 2021 2021-06 10.3808/jei.202000443 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Communication and Cooperation Between the Medical Academy, Medical Association, and Local Government: Health Counseling Program After Recovery From Coronavirus Disease 2019 (COVID-19) in Daegu ⓘ We are currently experiencing the disaster of the COVID-19 pandemic. Since the first case of Coronavirus disease 2019 (COVID-19) was confirmed in South Korea on January 20, the number of COVID-19 cases in South Korea has been rapidly increasing until early March due to a local spread in Daegu, which is one of the eight metropolitan cities in South Korea with a population of 2.5 million. As the medical academy has social accountability as professionals, Daegu-Gyeongbuk branch of the Korean Academy of Family Medicine (Daegu-Gyeongbuk branch) developed the health counseling program for discharged COVID-19 patients. The Daegu-Gyeongbuk branch communicated with Daegu Medical Association and Daegu city for this program and incorporated available resources and capabilities as a leader of this program. This newly developed counseling program consists of medical consultations, sending healthcare brochures and medical supplies, and the appraisal at the end of the program. Not only COVID-19 related symptoms but also other psychological problems are also dealt with during consultations. This program started on March 18, and over 1,700 recovered patients have been receiving counseling as of April 28. Communication and cooperation between the medical academy, medical association, and government are essential to overcome the COVID-19 pandemic. Besides, we expect to apply this health counseling program and our model of setting this program cooperating with medical association and government to different infectious pandemic crisis. ⓘ Kim, Yun-A; Lee, Geon Ho; Lee, Keun-Mi; Ko, Hae-Jin; Lee, DongWook; Kim, A-Sol ⓘ Catholic Univ Korea, Dept Family Med, Sch Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Med Ctr, Dept Family Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Family Med, Daegu, South Korea; Dongguk Univ, Sch Med, Dept Family Med, Gyeongju, South Korea ⓘ Lee, Geon Ho/HLG-1707-2023 ⓘ 57205025491; 36104322100; 56101036000; 54393415700; 57263010900; 57203290656 ⓘ totoslee@cu.ac.kr; ⓘ FRONTIERS IN PUBLIC HEALTH ⓘ FRONT PUBLIC HEALTH ⓘ 2296-2565 8 SCIE;SSCI PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH ⓘ 2021 6.461 9.6 0.29 2025-07-30 ⓘ 4 4 COVID-19; medical academia; medical association; local government; consultation ⓘ ⓘ consultation; COVID-19; local government; medical academia; medical association ⓘ Adult; Aged; Aged, 80 and over; Communication; Counseling; COVID-19; Female; Humans; Intersectoral Collaboration; Local Government; Male; Middle Aged; Pandemics; Republic of Korea; SARS-CoV-2; Schools, Medical; Societies, Medical; Survivors; adult; aged; counseling; epidemiology; female; government; human; interpersonal communication; intersectoral collaboration; male; medical school; medical society; middle aged; organization and management; pandemic; psychology; South Korea; survivor; very elderly ⓘ English 2021 2021-01-13 10.3389/fpubh.2020.563757 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Poly(acrylates) showing critical fluorescence change in response to heat ⓘ Poly(acrylate) plastics in which medium to long alkyl chain acrylate monomers and a molecular rotor (MR) are bonded covalently, were prepared and examined to show unique fluorescence (FL) emission behaviors in response to heat. Selected long alkyl chain acrylate monomers and fluorescent MR monomers were UV cured using a little amount of cross-linker to produce emissive plastic films with excellent features: surface brilliance, transparency, mechanical strength, and chemical resistance. The prepared acrylic plastics experienced distinct reversible crystal-to-liquid local phase change of the long alkyl chains under repeated heating and cooling with high absolute enthalpies of fusion. The FL emission was weakened at a narrow temperature range, during heating, while a significant FL enhancement was observed during cooling. ⓘ Jin, Young-Jae; Kim, Heesang; Kwak, Giseop ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Polymer Sci & Engn, Polymer Nanomat Lab, 1370 Sankyuk Dong, Daegu 702701, South Korea; Korea Res Inst Chem Technol KRICT, Reliabil Assessment Ctr Chem Mat, 141 Gajeong Ro, Daejeon 305600, South Korea ⓘ ⓘ 55307815700; 57226091356; 17137322300 ⓘ gkwak@knu.ac.kr; ⓘ DYES AND PIGMENTS ⓘ DYES PIGMENTS ⓘ 0143-7208 1873-3743 194 SCIE CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, TEXTILES ⓘ 2021 5.122 9.6 0 2025-07-30 ⓘ 1 0 Acrylic plastic; Fluorescence; Molecular rotor; Phase change material; Thermo-responsive polymer ⓘ POLYMERS; EMISSION ⓘ Acrylic plastic; Fluorescence; Molecular rotor; Phase change material; Thermo-responsive polymer ⓘ Chains; Cooling; Elastomers; Emission; Fluorescence; Heating; Monomers; Plastics; Acrylic monomers; Crosslinking; Elastomers; Phase change materials; Plastics; Salts; Acrylate monomers; Acrylic plastic; Emission behavior; Fluorescence emission; Long alkyl chains; Molecular rotors; Phase Change; Poly(acrylate); Thermoresponsive polymer; UV cured; Fluorescence ⓘ English 2021 2021-10 10.1016/j.dyepig.2021.109647 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo ⓘ Background Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the regulation mechanism and precise target of this substance remain undiscovered in CRC. In this study, we found that CTD inhibited CRC cell proliferation in vitro and in vivo by targeting AKT. Methods Effects of CTD on colon cancer cell growth in vitro were evaluated in cell proliferation assays, migration and invasion, propidium iodide, and annexin V-staining analyses. Targets of CTD were identified utilizing phosphoprotein-specific antibody array; Costunolide-sepharose conjugated bead pull-down analysis and knockdown techniques. We investigated the underlying mechanisms of CTD by ubiquitination, immunofluorescence staining, and western blot assays. Cell-derived tumour xenografts (CDX) in nude mice and immunohistochemistry were used to assess anti-tumour effects of CTD in vivo. Results CTD suppressed the proliferation, anchorage-independent colony growth and epithelial-mesenchymal transformation (EMT) of CRC cells including HCT-15, HCT-116 and DLD1. Besides, the CTD also triggered cell apoptosis and cell cycle arrest at the G2/M phase. The CTD activates and induces p53 stability by inhibiting MDM2 ubiquitination via the suppression of AKT's phosphorylation in vitro. The CTD suppresses cell growth in a p53-independent fashion manner; p53 activation may contribute to the anticancer activity of CTD via target AKT. Finally, the CTD decreased the volume of CDX tumors without of the body weight loss and reduced the expression of AKT-MDM2-p53 signaling pathway in xenograft tumors. Conclusions Our project has uncovered the mechanism underlying the biological activity of CTD in colon cancer and confirmed the AKT is a directly target of CTD. All of which These results revealed that CTD might be a new AKT inhibitor in colon cancer treatment, and CTD is worthy of further exploration in preclinical and clinical trials. ⓘ Huang, Hai; Park, Song; Zhang, Haibo; Park, Sijun; Kwon, Wookbong; Kim, Enugyung; Zhang, Xiujuan; Jang, Soyoung; Yoon, Duhak; Choi, Seong-Kyoon; Yi, Jun-koo; Kim, Sung-hyun; Dong, Zigang; Lee, Mee-hyun; Ryoo, Zaeyoung; Kim, Myoung Ok ⓘ Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, ITRD, Sangju 37224, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu, South Korea; DGIST, Div Biotechnol, Daegu, South Korea; Fudan Univ, Huashan Hosp, Dept Pulm & Crit Care Med, Shanghai 200040, Peoples R China; Gyeongsangbuk Do Livestock Res Inst, Yeongju, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam, South Korea; China US Henan Hormel Canc Inst, Zhengzhou 450008, Henan, Peoples R China; Dongshin Univ, Coll Korean Med, Naju 58245, Jeollanamdo, South Korea ⓘ RYOO, ZAEYOUNG/AAQ-1573-2020; Yi, Junkoo/JBR-8507-2023; Zhang, Haibo/HLP-9266-2023 ⓘ 57215021952; 57139047900; 57221648126; 54682212300; 57139843600; 57217871658; 57222649821; 57139360300; 7202875754; 55505432500; 56182537200; 59103241900; 57225955964; 58960253600; 16937104900; 8934745900 ⓘ mhyun_lee@hanmail.net;jaewoong64@hanmail.net;ok4325@knu.ac.kr; ⓘ JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH ⓘ J EXP CLIN CANC RES ⓘ 1756-9966 40 1 SCIE ONCOLOGY ⓘ 2021 12.658 9.6 2 2025-07-30 ⓘ 31 33 Colon cancer; Costunolide (CTD); AKT; AKT; MDM2; p53 pathway; Ubiquitination; Xenograft model ⓘ CYCLE PROGRESSION; C-MYC; P53; MDM2; PHOSPHORYLATION; ACTIVATION; PATHWAY; AKT-MDM2-P53; INHIBITION; DEGRADATION ⓘ AKT; AKT/MDM2/p53 pathway; Colon cancer; Costunolide (CTD); Ubiquitination, Xenograft model ⓘ Animals; Apoptosis; Colorectal Neoplasms; Female; Humans; Mice; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Transfection; Xenograft Model Antitumor Assays; costunolide; mouse double minute 2 homolog; protein kinase B; protein p53; costunolide; protein kinase B; sesquiterpene; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; body weight loss; cancer cell culture; cancer growth; cancer prevention; cell invasion; cell migration; cell proliferation; cell proliferation assay; cellular distribution; colon cancer; colorectal cancer cell line; controlled study; DLD-1 cell line; drug effect; drug efficacy; drug mechanism; drug structure; enzyme phosphorylation; epithelial mesenchymal transition; flow cytometry; G2 phase cell cycle checkpoint; HCT 116 cell line; HCT 15 cell line; human; human cell; immunofluorescence; immunohistochemistry; in vitro study; in vivo study; male; mouse; MTT assay; nonhuman; nude mouse; priority journal; propidium iodide assay; protein expression; protein stability; protein targeting; quantitative analysis; real time polymerase chain reaction; RNA extraction; signal transduction; staining; treatment duration; tumor volume; tumor xenograft; ubiquitination; Western blotting; wound healing assay; animal; apoptosis; colorectal tumor; drug screening; female; genetic transfection; genetics; metabolism ⓘ English 2021 2021-03-30 10.1186/s13046-021-01895-w ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer ⓘ Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge. Methods RNA-seq, qPCR, western blot and immunohistochemistry were employed to identify and confirm the high expression of indolethylamine N-methyltransferase (INMT) in CRPC and the clinical relevance. Chip assay was used to identify Histone-Lysine N-Methyltransferase (SMYD3) as a major epigenetic regulator of INMT. LC-MS/MS were used to identify new substrates of INMT methylation in CRPC tissues. Gene knockdown/overexpression, MTT and mouse cancer models were used to examine the role of INMT as well as the anticancer efficacy of INMT inhibitor N,N-dimethyltryptamine (DMT), the SMYD3 inhibitor BCl-12, the selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC), and the newly identified endogenous INMT substrate Bis(7)-tacrine. Results We found that the expression of INMT was highly increased in CRPC and was correlated with poor prognosis of clinical prostate cancer (PCa). INMT promoted PCa castration resistance via detoxification of anticancer metabolites. Knockdown of INMT or treatment with INMT inhibitor N,N-dimethyltryptamine (DMT) significantly suppressed CRPC development. Histone-Lysine N-Methyltransferase SMYD3 was a major epigenetic regulator of INMT expression, treatment with SMYD3 inhibitor BCl-121 suppressed INMT expression and inhibits CRPC development. Importantly, INMT knockdown significantly increased the anticancer effect of the exogenous selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC) as well as the endogenous metabolite Bis(7)-tacrine. Conclusions Our study suggests that INMT drives PCa castration resistance through detoxification of anticancer metabolites, targeting INMT or its regulator SMYD3 or/and its methylation metabolites represents an effective therapeutic avenue for CRPC treatment. ⓘ Zhong, Shangwei; Jeong, Ji-Hak; Huang, Changhao; Chen, Xueyan; Dickinson, Shohreh Iravani; Dhillon, Jasreman; Yang, Li; Luo, Jun-Li ⓘ Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu 41566, South Korea; H Lee Moffitt Canc Ctr & Res Inst, Dept Pathol, 2902 Magnolia Dr, Tampa, FL 33612 USA; Zhengzhou Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Zhengzhou 450052, Henan, Peoples R China ⓘ ⓘ 55639445400; 55913671500; 57190050818; 59784802100; 37030843300; 26024982200; 57213065734; 26327010000 ⓘ yangli0727@zzu.edu.cn;jlluo@scripps.edu; ⓘ JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH ⓘ J EXP CLIN CANC RES ⓘ 1756-9966 40 1 SCIE ONCOLOGY ⓘ 2021 12.658 9.6 0.9 2025-07-30 ⓘ 21 18 INMT; SMYD3; Prostate cancer castration-resistance; DMT; MSA; MSC; Bis(7)-tacrine ⓘ INDOLETHYLAMINE-N-METHYLTRANSFERASE; ANDROGEN DEPRIVATION THERAPY; METABOLITE IDENTIFICATION; METHYLSELENINIC ACID; ANTI-ALZHEIMERS; GENE CLONING; RECEPTOR; SELENIUM; SMYD3; PROGRESSION ⓘ Bis(7)-tacrine; DMT; INMT; MSA; MSC; Prostate cancer castration-resistance; SMYD3 ⓘ Animals; Apoptosis; Cell Proliferation; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Male; Methyltransferases; Mice; Prognosis; Prostatic Neoplasms, Castration-Resistant; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; indolethylamine n methyltransferase; n,n dimethyltryptamine; protein methyltransferase; selenium derivative; unclassified drug; enzyme inhibitor; histone lysine methyltransferase; methyltransferase; SMYD3 protein, human; tryptamine N-methyltransferase; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer prognosis; cancer tissue; castration resistant prostate cancer; chromatin immunoprecipitation sequencing; controlled study; correlational study; gene expression; gene knockdown; immunohistochemistry; liquid chromatography-mass spectrometry; male; mouse; nonhuman; polymerase chain reaction; protein expression; protein targeting; RNA sequence; signal transduction; Western blotting; animal; apoptosis; castration resistant prostate cancer; cell proliferation; DNA methylation; drug effect; drug screening; enzymology; gene expression regulation; genetic epigenesis; genetics; human; metabolism; pathology; prognosis; tumor cell culture ⓘ English 2021 2021-09-29 10.1186/s13046-021-02109-z ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state ⓘ Background: The progression of prostate cancer (PC) to the highly aggressive metastatic castration-resistant prostate cancer (mCRPC) or neuroendocrine prostate cancer (NEPC) is a fatal condition and the underlying molecular mechanisms are poorly understood. Here, we identified the novel transcriptional factor ZNF507 as a key mediator in the progression of PC to an aggressive state. Methods: We analyzed ZNF507 expression in the data from various human PC database and high-grade PC patient samples. By establishment of ZNF507 knockdown and overexpression human PC cell lines, we assessed in vitro PC phenotype changes including cell proliferation, survival, migration and invasion. By performing microarray with ZNF507 knockdown PC cells, we profiled the gene clusters affected by ZNF507 knockdown. Moreover, ZNF507 regulated key signal was evaluated by dual-luciferase reporter and chromatin immunoprecipitation (ChIP) assays. Finally, we performed xenograft and in vivo metastasis assay to confirm the effect of ZNF507 knockdown in PC cells. Results: We found that ZNF507 expression was increased, particularly in the highly graded PC. ZNF507 was also found to be associated with metastatic PC of a high grade. Loss- or gain-of-function-based analysis revealed that ZNF507 promotes the growth, survival, proliferation, and metastatic properties of PC (e.g., epithelial-mesenchymal transition) by upregulating TGF-beta signaling. Profiling of gene clusters affected by ZNF507 knockdown revealed that ZNF507 positively regulated the transcription of TGFBR1, MAP3K8, and FURIN, which in turn promoted the progression of PC to highly metastatic and aggressive state. Conclusions: Our findings suggest that ZNF507 is a novel key regulator of TGF-beta signaling in the progression of malignant PC and could be a promising target for studying the development of advanced metastatic PCs. ⓘ Kwon, Wookbong; Choi, Seong-Kyoon; Kim, Daehwan; Kim, Hyeon-Gyeom; Park, Jin-Kyu; Han, Jee Eun; Cho, Gil-Jae; Yun, Sungho; Yu, Wookyung; Han, Se-Hyeon; Ha, Yun-Sok; Lee, Jun Nyung; Kwon, Tae Gyun; Cho, Dong-Hyung; Yi, Jun-Koo; Kim, Myoung Ok; Ryoo, Zae Young; Park, Song ⓘ DGIST, Core Prot Resources Ctr, Daegu, South Korea; DGIST, Div Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu, South Korea; Hanyang Univ, Sch Media Commun, Wangsimni Ro 222, Seoul, South Korea; SBS Seoul Broadcasting Syst, Dept News Team, Mokdongseo Ro 161, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Gyeongsangbuk do Livestock Res Inst, Yeongju, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, ITRD, Sangju 37224, South Korea ⓘ Yi, Junkoo/JBR-8507-2023; Choi, Hye Rin/JDV-9065-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 ⓘ 57139843600; 55505432500; 57212363780; 57210911747; 35213723500; 57214671240; 7201438083; 57201366734; 56410212300; 57210915063; 35487226400; 16301364600; 15073765400; 35093684400; 56182537200; 8934745900; 16937104900; 57139047900 ⓘ cskbest@dgist.ac.kr;jaewoong64@knu.ac.kr;cristaling@dgist.ac.kr; ⓘ JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH ⓘ J EXP CLIN CANC RES ⓘ 1756-9966 40 1 SCIE ONCOLOGY ⓘ 2021 12.658 9.6 0.76 2025-07-30 ⓘ 13 12 Prostate cancer; Metastasis; mCRPC; ZNF507; TGF-beta signal ⓘ CARCINOMA-CELL LINE; NEUROENDOCRINE DIFFERENTIATION; EXPRESSION; INFLAMMATION; MECHANISMS; LANDSCAPE; GROWTH; TUMORS; FURIN ⓘ mCRPC; Metastasis; Prostate cancer; TGF-β signal; ZNF507 ⓘ Animals; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Disease Susceptibility; DNA-Binding Proteins; Gene Expression; Gene Knockdown Techniques; Heterografts; Humans; Male; MAP Kinase Kinase Kinases; Mice; Models, Biological; Prognosis; Prostatic Neoplasms; Proto-Oncogene Proteins; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta; furin; stress activated protein kinase 1; transcription factor; transcription factor ZNF507; transforming growth factor beta receptor 1; unclassified drug; biological marker; DNA binding protein; MAP3K8 protein, human; mitogen activated protein kinase kinase kinase; oncoprotein; TGFBR1 protein, human; transforming growth factor beta; 22Rv1 cell line; animal experiment; animal model; animal tissue; Article; cancer grading; cancer growth; cell invasion; cell migration; cell proliferation; cell survival; chromatin immunoprecipitation; controlled study; data base; disease association; enzyme activation; epithelial mesenchymal transition; FURIN gene; gain of function mutation; gene cluster; gene expression; gene function; gene knockdown; gene overexpression; in vitro study; in vivo study; loss of function mutation; luciferase assay; MAP3K8 gene; metastasis; metastatic castration resistant prostate cancer; microarray analysis; mouse; nonhuman; PC-3 [Human prostate carcinoma] cell line; PC-3M cell line; phenotype; prostate cancer; RWPE-1 cell line; TGF beta signaling; TGFBR1 gene; transcription regulation; tumor xenograft; upregulation; animal; apoptosis; biological model; cell motion; disease exacerbation; disease predisposition; genetics; human; male; metabolism; pathology; prognosis; prostate tumor; signal transduction; tumor cell line; xenograft ⓘ English 2021 2021-09-18 10.1186/s13046-021-02094-3 ⓘ 바로가기 바로가기 바로가기 바로가기
페이지 이동: