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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases | Cardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorders; however, sometimes, side effects and complications caused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been reported to reduce the impact of thrombotic conditions and improve cardiovascular health by antiplatelet mechanisms. This review provides (1) a comprehensive insight into the available pharmacological options from ginseng and ginsenosides (saponin and nonsaponin fractions) for platelet-originated cardiovascular disorders; (2) a discussion on the impact of specific functional groups on the modulation of platelet functions and how structural modifications among ginsenosides affect platelet activation, which may further provide a basis for drug design, optimization, and the development of ginsenoside scaffolds as pharmacological antiplatelet agents; (3) an insight into the synergistic effects of ginsenosides on platelet functions; and (4) a perspective on future research and the development of ginseng and ginsenosides as super nutraceuticals. (C) 2019 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Irfan, Muhammad; Kim, Minki; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Lab Vet Physiol & Cell Signaling, 80 Daehakro, Daegu 41566, South Korea | Irfan, Muhammad/AAY-1961-2021; Rhee, Man/O-5705-2016 | 35069404400; 57199747297; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 1 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 2.29 | 2025-06-25 | 63 | 65 | Antiplatelet; Ginsenosides; Nutraceutical; Structural modification; Synergism | INHIBITS PLATELET ACTIVATION; RED GINSENG; PANAX-GINSENG; THROMBOXANE A(2); TOTAL SAPONIN; THROMBUS FORMATION; GLYCOPROTEIN IIB/IIIA; PHOSPHORYLATION; MECHANISMS; HEMOSTASIS | Antiplatelet; Ginsenosides; Nutraceutical; Structural modification; Synergism | antithrombocytic agent; cyclic AMP; ginseng extract; ginsenoside; ginsenoside Rg 1; ginsenoside Rg 2; ginsenoside Rg 3; ginsenoside Rg 5; ginsenoside Rg 6; ginsenoside rh 1; ginsenoside Rh 2; ginsenoside rh 4; ginsenoside rk1; ginsenoside rk3; ginsenoside rs3; ginsenoside rs4; ginsenoside rs5; integrin; mitogen activated protein kinase; mitogen activated protein kinase p38; stress activated protein kinase; unclassified drug; vasodilator stimulated phosphoprotein; antiplatelet activity; cardiovascular disease; drug potentiation; ginseng; human; hydrogenation; nonhuman; pharmacological parameters; priority journal; protein phosphorylation; protein secretion; Review; thrombocyte activation; thrombocyte aggregation; thrombocyte function; upregulation | English | 2020 | 2020-01 | 10.1016/j.jgr.2019.05.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | BREAKDOWN OF THE EXTRACELLULAR MATRIX RECAPITULATES OSTEOARTHRITIC PHENOTYPES IN 3D-HYDROGEL MODEL: THE VALIDATION OF IN VITRO CELL CULTURE MODEL OF OSTEOARTHRITIS | Jung, Y. -K.; Shin, D.; Parke, D.; Kim, J.; Han, S. | Gyeongsang Natl Univ Hosp, Biomed Res Inst, Jinju, South Korea; Daegu Fatima Hosp, Daegu, South Korea; Chungnam Natl Univ Hosp, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea | OSTEOARTHRITIS AND CARTILAGE | OSTEOARTHR CARTILAGE | 1063-4584 | 1522-9653 | 28 | SCIE | ORTHOPEDICS;RHEUMATOLOGY | 2020 | 6.576 | 1.8 | 1 | English | 2020 | 2020-04 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | Meeting Abstract | Clinical aspects of severe cutaneous adverse reactions caused by beta-lactam antibiotics: A study from the Korea SCAR Registry | Shim, J.; Kim, M.; Nam, Y.; Kang, H.; Kang, D. Y.; Koh, Y.; Kim, S.; Kim, S.; Park, J.; Park, H.; Ye, Y.; Park, S. J.; Cho, Y. | Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Busan, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Drug Safety Monitoring Ctr, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Sch Med, Gwangju, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; Chonbuk Natl Univ, Dept Internal Med, Sch Med, Jeonju, South Korea | Kim, Hye/AAF-7609-2020; Kim, Sara/F-2951-2013 | ALLERGY | ALLERGY | 0105-4538 | 1398-9995 | 75 | SCIE | ALLERGY;IMMUNOLOGY | 2020 | 13.146 | 1.8 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | ENDOGENOUSLY EXPRESSED CXC CHEMOKINE RECEPTOR TYPE 7 IS INVOLVED IN INFLAMMATION OF CHONDROCYTE FROM MICE | Kim, G.; Han, M. -S.; Nam, E.; Shin, D.; Cho, H. -J.; Lee, E. -J.; Jang, J. -A.; Park, H. -R. | Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Daegu Fatima Hosp, Fatima Res Inst, Lab Arthrit & Bone Biol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Internal Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Orthopaed, Daegu, South Korea | Han, Moonsu/KXR-2750-2024 | OSTEOARTHRITIS AND CARTILAGE | OSTEOARTHR CARTILAGE | 1063-4584 | 1522-9653 | 28 | SCIE | ORTHOPEDICS;RHEUMATOLOGY | 2020 | 6.576 | 1.8 | 1 | English | 2020 | 2020-04 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells | Background: Recently, beneficial roles of ginsenoside F2 (GF2), a minor constituent of Panax ginseng, have been demonstrated in diverse inflammatory diseases. However, its roles in alcoholic liver inflammation and injury have not been clearly understood. Here, we investigated the underlying mechanism by which GF2 ameliorated alcoholic liver injury. Methods: To induce alcoholic liver injury, C57BL/6J wild type (WT) or interleukin (IL)-10 knockout (KO) mice were orally administered with ethanol (3 g/kg) or ethanol-containing GF2 (50 mg/kg) for 2 wk. Liver injury and infiltration of macrophages and neutrophils were evaluated by serum biochemistry and immunohistochemistry, respectively. The changes of hepatic immune cells were assessed by flow cytometry and polymerase chain reaction analysis. In vitro differentiation of naive T cells was performed. Results: GF2 treatment significantly attenuated alcoholic liver injury, in which infiltrations of inflammatory macrophages and neutrophils were decreased. Moreover, the frequencies of Foxp(3+) regulatory T cells (Tregs) increased but IL-17-producing T (Th17) cells decreased in GF2-treated mice compared to controls. Furthermore, the mRNA expression of IL-10 and Foxp3 was significantly increased, whereas IL-17 mRNA expression was suppressed in GF2-treated mice. However, these beneficial roles of GF2 were not observed in GF2-treated IL-10 KO mice, suggesting a critical role of IL-10. Similarly, GF2 treatment suppressed differentiation of naive T cells into Th17 cells by inhibiting ROR gamma t expression and stimulating Foxp3 expression. Conclusion: The present study suggests that GF2 treatment attenuates alcoholic liver injury by increasing IL-10 expression and Tregs and decreasing IL-17 expression and Th17 cells. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Kim, Myung-Ho; Kim, Hee-Hoon; Jeong, Jong-Min; Shim, Young-Ri; Lee, Jun-Hee; Kim, Ye Eun; Ryu, Tom; Yang, Keungmo; Kim, Kyu-Rae; Jeon, Byeong-Min; Kim, Sun Chang; Jung, Jae-Kwang; Choi, Jae-Kap; Lee, Young-Sun; Byun, Jin-Seok; Jeong, Won-Il | Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Liver Res, Daejeon 34141, South Korea; Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea; Korea Adv Inst Sci & Technol, Intelligent Synthet Biol Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea | JEONG, WON IL/B-6615-2011; Lee, Young-Sun/ABI-6420-2020; Shim, Young-Ri/MXL-1653-2025; Jeong, Jong-Min/ISS-5030-2023; Kim, Sun/C-2026-2011 | 57189845483; 57204146198; 56336320800; 57191615394; 57203144429; 57205639506; 59837721700; 57211494507; 57216726647; 57207818683; 8242246500; 55970994400; 7501395602; 13407433000; 55430621800; 8983219500 | jsbyun@knu.ac.kr;wijeong@kaist.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 6 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 1.65 | 2025-06-25 | 23 | 27 | Interleukin-10; Interleukin-17; Macrophage; Neutrophil; Panax ginseng | PANAX-GINSENG; DIFFERENTIATION; MECHANISMS; INFLAMMATION; ACTIVATION; DISEASES; PATHWAY; FOXP3; RG1 | Interleukin-10; Interleukin-17; Macrophage; Neutrophil; Panax ginseng | alanine aminotransferase; alcohol; antiinflammatory agent; aspartate aminotransferase; cholesterol; ginsenoside; ginsenoside f2; interleukin 10; liver protective agent; transcription factor FOXP3; triacylglycerol; unclassified drug; alanine aminotransferase blood level; alcohol consumption; alcohol liver cirrhosis; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; aspartate aminotransferase blood level; binge drinking; blood biochemistry; CD4+ T lymphocyte; cholesterol blood level; controlled study; drug mechanism; drug megadose; flow cytometry; immunocompetent cell; immunohistochemistry; liver protection; lymphocyte differentiation; macrophage; male; mouse; mRNA expression level; neutrophil; neutrophil chemotaxis; nonhuman; optimal drug dose; polymerase chain reaction; priority journal; regulatory T lymphocyte; Th17 cell; triacylglycerol blood level | English | 2020 | 2020-11 | 10.1016/j.jgr.2020.03.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses Ched phenotypic variation in CT26 colon cancer cells | This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1 beta. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR-and LPS-treated J774A.1 macrophages. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Baik, Ji Sue; Seo, You Na; Yi, Joo Mi; Rhee, Man Hee; Park, Moon-Taek; Kim, Sung Dae | Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 46033, South Korea; Inje Univ, Coll Med, Dept Microbiol & Immunol, Busan, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu, South Korea | Rhee, Man/O-5705-2016 | 55193419800; 57201334908; 56611171900; 57211035357; 7404490344; 55156746000 | mtpark@dirams.re.kr;sdkim@dirams.re.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 6 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 0.58 | 2025-06-25 | 9 | 9 | Cancer; Ginsenoside-Rp1; Macrophages; Panax ginseng; Radiation | ACTIVATION; PATHWAY; TUMOR | Cancer; Ginsenoside-Rp1; Macrophages; Panax ginseng; Radiation | ginsenoside; ginsenoside rp1; interleukin 1beta; lipopolysaccharide; nitric oxide; unclassified drug; animal cell; animal experiment; animal model; Article; cell viability; chemical structure; colon cancer cell line; controlled study; DNA damage; gene activation; IC50; ionizing radiation; macrophage; male; mouse; nonhuman; phenotypic variation; priority journal; radiation exposure | English | 2020 | 2020-11 | 10.1016/j.jgr.2020.01.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B-irradiated hairless mice | Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means "cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation. Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin. Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone. Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product. (C) 2019 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Saba, Evelyn; Kim, Seung-Hyung; Lee, Yuan Yee; Park, Chae-Kyu; Oh, Jae-Wook; Kim, Tae-Hwan; Kim, Hyun-Kyoung; Roh, Seong-Soo; Rhee, Man Hee | Kyungpook Natl Univ, Lab Physiol & Cell Signalling, Daegu, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon, South Korea; Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul, South Korea; Seowon Univ, Dept Food Sci & Engn, Chungbuk, South Korea; Daegu Haany Univ, Coll Korean Med, 64 Gil,25 Suseongro, Daegu 42158, South Korea | Oh, Jae-Wook/D-3597-2011; Saba, Evelyn/JLN-1878-2023; Kim, Seung-Hyung/AAA-4707-2020; Kim, Hyun/AAT-6695-2021; Rhee, Man/O-5705-2016; Yuan Yee, Lee/ABH-8956-2022 | 56721112000; 54383305300; 57203798815; 55885553100; 34875481900; 57202984578; 55791359100; 12752302700; 57211035357 | ddede@dhu.ac.kr;rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 1.46 | 2025-06-25 | 20 | 19 | Antiaging; Human trials; Korean Red Ginseng extract; Melanogenesis; Wrinkles | INHIBITS MELANOGENESIS; SKIN; MELANIN; ACID; METALLOPROTEINASES; INFLAMMATION; DEGRADATION; MECHANISMS; DAMAGE | Antiaging; Human trials; Korean Red Ginseng extract; Melanogenesis; Wrinkles | gelatinase A; gelatinase B; ginseng extract; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rd; ginsenoside Re; ginsenoside Rf; ginsenoside Rg 1; ginsenoside Rg 2; ginsenoside Rg 3; ginsenoside Rh 2; glyceraldehyde 3 phosphate dehydrogenase; interleukin 1beta; melanin; microphthalmia associated transcription factor; monophenol monooxygenase; RNA directed DNA polymerase; animal experiment; animal model; antiaging activity; Article; B16-F10 cell line; clinical evaluation; collagen degradation; controlled study; cosmetic industry; cream; drug efficacy; ginseng; hairless mouse; human; human cell; in vitro study; in vivo study; irradiation; melanogenesis; moisture; mouse; nonhuman; photoaging; priority journal; protein expression; skin; transcription initiation; translation initiation; ultraviolet B radiation; wrinkle | English | 2020 | 2020-05 | 10.1016/j.jgr.2019.05.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings | Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K. (C) 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | Choi, Min-Koo; Jin, Sojeong; Jeon, Ji-Hyeon; Kang, Woo Youl; Seong, Sook Jin; Yoon, Young-Ran; Han, Yong-Hae; Song, Im-Sook | Dankook Univ, Coll Pharm, Cheonan, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Clin Trial Ctr, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, BK21 Plus KNU Biomed Convergence Program Creat Ta, Dept Biomed Sci, Daegu, South Korea; Daewoong Pharmaceut, Life Sci Inst, Yongin, Gyeonggi Do, South Korea | Yoon, Young-Ran/GLT-0172-2022 | 8695781400; 57204690167; 57204685946; 56816263900; 57211130049; 14629744500; 36077338500; 7201564500 | songimsook1@gmail.com; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 2 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 3.3 | 2025-06-25 | 47 | 47 | ginsenosides; pharmacokinetics; red ginseng; single and repeated administration; tolerability | PANAX-GINSENG; METABOLISM; RB-1; CYTOCHROME-P450; BIOAVAILABILITY; COMPONENTS; ABSORPTION | ginsenosides; pharmacokinetics; red ginseng; single and repeated administration; tolerability | ginseng extract; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rc; ginsenoside Rd; adult; area under the curve; Article; blood pressure measurement; blood sampling; body temperature measurement; Caco-2 cell line; controlled study; drug blood level; drug megadose; drug safety; drug tolerability; human; human experiment; laboratory test; maximum concentration; normal human; priority journal; randomized controlled trial; time to maximum plasma concentration | English | 2020 | 2020-03 | 10.1016/j.jgr.2018.10.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity | Despite its outstanding clinical success, immune checkpoint blockade remains ineffective in many patients. Accordingly, combination therapy capable of achieving greater antitumor immunity is urgently required. Here, we report that limiting glutamine metabolism in cancer cells bolsters the effectiveness of anti-programmed death ligand-1 (PD-L1) antibody. Inhibition of glutamine utilization increased PD-L1 levels in cancer cells, thereby inactivating co-cultured T cells. Under glutamine-limited conditions, reduced cellular GSH levels caused an upregulation of PD-L1 expression by impairing SERCA activity, which activates the calcium/NF-kappa B signaling cascade. Consequently, in tumors grown in immunocompetent mice, inhibition of glutamine metabolism decreased the antitumor activity of T cells. In combination with anti-PD-L1, however, glutamine depletion strongly promoted the antitumor efficacy of T cells in vitro and in vivo due to simultaneous increases in Fas/CD95 levels. Our results demonstrate the relevance of cancer glutamine metabolism to antitumor immunity and suggest that co-targeting of glutamine metabolism and PD-L1 represents a promising therapeutic approach. | Byun, Jun-Kyu; Park, Mihyang; Lee, Seunghyeong; Yun, Jae Won; Lee, Jaebon; Kim, Jae Sun; Cho, Sung Jin; Jeon, Hui-Jeon; Lee, In-Kyu; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41566, South Korea; Vet Hlth Serv Med Ctr, Vet Med Res Inst, Seoul 05368, South Korea; Sungkyunkwan Univ, Dept Lab Med & Genet, Samsung Med Ctr, Sch Med, Seoul 06355, South Korea; Sungkyunkwan Univ, Sch Med, Seoul 16419, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea | ; Lee, In-Kyu/AAR-6374-2021; Lee, Jaebon/JNT-2600-2023; Yun, Jae/AAT-4892-2020 | 57190427423; 57208338147; 57204501802; 55454111800; 57208329586; 57208335577; 58735369700; 57193694479; 36071537600; 35335932600; 57202558343 | ykchoi@knu.ac.kr;kpark@knu.ac.kr; | MOLECULAR CELL | MOL CELL | 1097-2765 | 1097-4164 | 80 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 17.97 | 1.9 | 5.26 | 2025-06-25 | 157 | 147 | antitumor immunity; glutamine; PD-L1; SERCA | Aged; Animals; Antibodies, Monoclonal; Apoptosis; B7-H1 Antigen; Cell Proliferation; Female; Glutamine; Glutathione; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasms; Sarcoplasmic Reticulum Calcium-Transporting ATPases; T-Lymphocytes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; caspase 3; caspase 7; ecalectin; Fas antibody; Fas ligand; glutamine; glutathione; glutathione disulfide; immune checkpoint inhibitor; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 4; interleukin 6; multidrug resistance associated protein 2; nuclear protein; programmed death 1 ligand 1; reduced nicotinamide adenine dinucleotide phosphate; transforming growth factor beta1; tumor necrosis factor; ATP2A1 protein, human; CD274 protein, human; glutamine; glutathione; monoclonal antibody; programmed death 1 ligand 1; sarcoplasmic reticulum calcium transporting adenosine triphosphatase; aged; animal cell; animal experiment; animal model; animal tissue; Article; cancer cell; cancer therapy; CD8+ T lymphocyte; clinical article; controlled study; CT26 cell line; enzyme inhibition; female; flow cytometry; human; human cell; immunohistochemistry; in vitro study; in vivo study; male; mouse; NCI-H460 cell line; non small cell lung cancer; nonhuman; oxidative stress; protein depletion; protein expression; real time polymerase chain reaction; T lymphocyte; tumor immunity; tumor xenograft; upregulation; volume; animal; apoptosis; Bagg albino mouse; C57BL mouse; cell proliferation; drug effect; drug screening; genetics; immunology; metabolism; neoplasm; nude mouse; pathology; tumor cell culture | English | 2020 | 2020-11-19 | 10.1016/j.molcel.2020.10.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial | Background Margetuximab, a novel, investigational, Fc-engineered, anti-HER2 monoclonal antibody, is designed to more effectively potentiate innate immunity than trastuzumab. We aimed to evaluate the safety, tolerability, and antitumour activity of margetuximab plus pembrolizumab (an anti-PD-1 monoclonal antibody) in previously treated patients with HER2-positive gastro-oesophageal adenocarcinoma. Methods CP-MGAH22-05 was a single-arm, open-label, phase 1b-2 dose-escalation and cohort expansion study done at 11 academic centres in the USA and Canada and 15 centres in southeast Asia (Korea, Taiwan, and Singapore) that enrolled men and women aged 18 years or older with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-unselected gastro-oesophageal adenocarcinoma, with an Eastern Cooperative Oncology Group performance status of 0 or 1, who had progressed after at least one previous line of therapy with trastuzumab plus chemotherapy in the locally advanced unresectable or metastatic setting. In the dose-escalation phase, nine patients were treated: three received margetuximab 10 mg/kg intravenously plus pembrolizumab 200 mg intravenously every 3 weeks and six received the recommended phase 2 dose of margetuximab 15 mg/kg plus pembrolizumab 200 mg intravenously every 3 weeks. An additional 86 patients were enrolled in the phase 2 cohort expansion and received the recommended phase 2 dose. The primary endpoints were safety and tolerability, assessed in the safety population (patients who received at least one dose of either margetuximab or pembrolizumab) and the objective response rate as assessed by the investigator according to both Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, in the response-evaluable population (patients with measurable disease at baseline and who received the recommended phase 2 dose of margetuximab and pembrolizumab). This trial is registered with ClinicalTrials.gov, NCT02689284. Recruitment for the trial has completed and follow-up is ongoing. Findings Between Feb 11, 2016, and Oct 2, 2018, 95 patients were enrolled. Median follow-up was 19.9 months (IQR 10.7-23.1). The combination therapy showed acceptable safety and tolerability; there were no dose-limiting toxicities in the dose-escalation phase. The most common grade 3-4 treatment-related adverse events were anaemia (four [4%]) and infusion-related reactions (three [3%]). Serious treatment-related adverse events were reported in nine (9%) patients. No treatment-related deaths were reported. Objective responses were observed in 17 (18.48%; 95% CI 11.15-27.93) of 92 evaluable patients. Interpretation These findings serve as proof of concept of synergistic antitumour activity with the combination of an Fc-optimised anti-HER2 agent (margetuximab) along with anti-PD-1 checkpoint blockade (pembrolizumab). Copyright (C) 2020 Elsevier Ltd. All rights reserved. | Catenacci, Daniel V. T.; Kang, Yoon-Koo; Park, Haeseong; Uronis, Hope E.; Lee, Keun-Wook; Ng, Matthew C. H.; Enzinger, Peter C.; Park, Se Hoon; Gold, Philip J.; Lacy, Jill; Hochster, Howard S.; Oh, Sang Cheul; Kim, Yeul Hong; Marrone, Kristen A.; Kelly, Ronan J.; Juergens, Rosalyn A.; Kim, Jong Gwang; Bendell, Johanna C.; Alcindor, Thierry; Sym, Sun Jin; Song, Eun-Kee; Chee, Cheng Ean; Chao, Yee; Kim, Sunnie; Lockhart, A. Craig; Knutson, Keith L.; Yen, Jennifer; Franovic, Aleksandra; Nordstrom, Jeffrey L.; Li, Daner; Wigginton, Jon; Davidson-Moncada, Jan K.; Rosales, Minori Koshiji; Bang, Yung-Jue | Univ Chicago, Med Ctr, Chicago, IL 60637 USA; Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea; Washington Univ, Sch Med, St Louis, MO USA; Duke Univ, Med Ctr, Durham, NC USA; Seoul Natl Univ, Bundang Hosp, Coll Med, Seongnam, South Korea; Duke NUS Med Sch, Natl Canc Ctr, Singapore, Singapore; Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA; Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea; Swedish Canc Inst, Seattle, WA USA; Yale Sch Med, New Haven, CT USA; Korea Univ, Guro Hosp, Seoul, South Korea; Korea Univ, Anam Hosp, Seoul, South Korea; Johns Hopkins Univ, Baltimore, MD USA; Baylor Univ, Med Ctr, Dallas, TX USA; McMaster Univ, Juravinski Canc Ctr, Hamilton, ON, Canada; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Sarah Cannon Res Inst, Nashville, TN USA; McGill Univ, Ctr Hlth, Montreal, PQ, Canada; Gachon Univ, Gil Med Ctr, Incheon, South Korea; Chonbuk Natl Univ, Sch Med, Jeonju, South Korea; Natl Univ Canc Inst, Singapore, Singapore; Taipei Vet Gen Hosp, Taipei, Taiwan; Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA; Mayo Clin, Jacksonville, FL 32224 USA; Guardant Hlth Inc, Redwood City, CA USA; MacroGenics, Rockville, MD USA; Seoul Natl Univ, Coll Med, Seoul, South Korea; Rutgers Canc Inst New Jersey, New Brunswick, NJ USA; Univ Colorado, Ctr Canc, Aurora, CO USA; Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA | Catenacci, Daniel/K-4177-2019; Bang, Yung Jue/J-2759-2012; Kang, Yoon-Koo/ABL-4264-2022; Park, Haeseong/AAL-7982-2021; Park, Se Hoon/GMX-1199-2022; Kim, Tae-You/J-2750-2012 | 9038220300; 7402784198; 57871376400; 16176825000; 35205887300; 56693812000; 6602251275; 25960261300; 54904660400; 12142081100; 7006621771; 55647062500; 7410200877; 57160067300; 26534483800; 8670902700; 59501049300; 55995000100; 6507538062; 16239809600; 7101904209; 15838788600; 7402865850; 57203918255; 7102750633; 7006048664; 57211159007; 8744484100; 7006831114; 57218223993; 7004297342; 6504542680; 57202220343; 18343561800 | dcatenac@bsd.uchicago.edu; | LANCET ONCOLOGY | LANCET ONCOL | 1470-2045 | 1474-5488 | 21 | 8 | SCIE | ONCOLOGY | 2020 | 41.316 | 1.9 | 9.11 | 2025-06-25 | 175 | 177 | ADVANCED GASTRIC-CANCER; TRASTUZUMAB EMTANSINE; DOUBLE-BLIND; HER2; CHEMOTHERAPY; PACLITAXEL; TAXANE; GATSBY | Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Receptor, ErbB-2; Stomach Neoplasms; epidermal growth factor receptor 2; margetuximab; pembrolizumab; antineoplastic agent; epidermal growth factor receptor 2; ERBB2 protein, human; immunological antineoplastic agent; margetuximab; monoclonal antibody; pembrolizumab; adult; anemia; antineoplastic activity; Article; cancer combination chemotherapy; drug dose escalation; drug potentiation; drug safety; drug tolerability; esophageal adenocarcinoma; female; gastro esophageal adenocarcinoma; gastro esophageal adenocarcinoma; human; infusion related reaction; inoperable cancer; major clinical study; male; multicenter study; phase 1 clinical trial; priority journal; prospective study; recommended drug dose; adenocarcinoma; aged; clinical trial; esophagus tumor; middle aged; stomach tumor | English | 2020 | 2020-08 | 10.1016/s1470-2045(20)30326-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Stable perovskite solar cells with efficiency exceeding 24.8% and 0.3-V voltage loss | Further improvement and stabilization of perovskite solar cell (PSC) performance are essential to achieve the commercial viability of next-generation photovoltaics. Considering the benefits of fluorination to conjugated materials for energy levels, hydrophobicity, and noncovalent interactions, two fluorinated isomeric analogs of the well-known hole-transporting material (HTM) Spiro-OMeTAD are developed and used as HTMs in PSCs. The structure-property relationship induced by constitutional isomerism is investigated through experimental, atomistic, and theoretical analyses, and the fabricated PSCs feature high efficiency up to 24.82% (certified at 24.64% with 0.3-volt voltage loss), along with long-term stability in wet conditions without encapsulation (87% efficiency retention after 500 hours). We also achieve an efficiency of 22.31% in the large-area cell. | Jeong, Mingyu; Choi, In Woo; Go, Eun Min; Cho, Yongjoon; Kim, Minjin; Lee, Byongkyu; Jeong, Seonghun; Jo, Yimhyun; Choi, Hye Won; Lee, Jiyun; Bae, Jin-Hyuk; Kwak, Sang Kyu; Kim, Dong Suk; Yang, Changduk | Ulsan Natl Inst Sci & Technol UNIST, Low Dimens Carbon Mat Ctr, Sch Energy & Chem Engn, Perovtron Res Ctr,Dept Energy Engn, Ulsan 44919, South Korea; Korea Inst Energy Res, Ulsan Adv Energy Technol R&D Ctr, Ulsan 44776, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Dept Energy Engn, Ulsan 44919, South Korea | Cho, Yongjoon/JQV-4650-2023; Choi, In Woo/AAA-7391-2022; Yang, Changduk/E-5933-2010; Kwak, Sang/G-6224-2010; Lee, Byongkyu/LMP-5176-2024 | 57194166140; 57189686986; 57189489354; 57202288982; 57200517006; 57200447284; 57217013993; 36903636000; 57210997741; 57202987231; 35326180700; 14421131200; 55816248100; 15770438700 | skkwak@unist.ac.kr;kimds@kier.re.kr;yang@unist.ac.kr; | SCIENCE | SCIENCE | 0036-8075 | 1095-9203 | 369 | 6511 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 47.728 | 2.1 | 45.4 | 2025-06-25 | 1331 | 1324 | HOLE-TRANSPORTING MATERIAL; HIGHLY EFFICIENT; PERFORMANCE; TRIHALIDE; POLYMER; BANDGAP; COST | energy efficiency; fuel cell; perovskite; solar power; Article; cyclic voltammetry; density functional theory; dynamics; electric potential; fluorination; impedance spectroscopy; light absorption; perovskite solar cell; priority journal; structure activity relation | English | 2020 | 2020-09-25 | 10.1126/science.abb7167 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Graphene/Half-Metallic Heusler Alloy: A Novel Heterostructure toward High-Performance Graphene Spintronic Devices | Graphene-based vertical spin valves (SVs) are expected to offer a large magnetoresistance effect without impairing the electrical conductivity, which can pave the way for the next generation of high-speed and low-power-consumption storage and memory technologies. However, the graphene-based vertical SV has failed to prove its competence due to the lack of a graphene/ferromagnet heterostructure, which can provide highly efficient spin transport. Herein, the synthesis and spin-dependent electronic properties of a novel heterostructure consisting of single-layer graphene (SLG) and a half-metallic Co2Fe(Ge0.5Ga0.5) (CFGG) Heusler alloy ferromagnet are reported. The growth of high-quality SLG with complete coverage by ultrahigh-vacuum chemical vapor deposition on a magnetron-sputtered single-crystalline CFGG thin film is demonstrated. The quasi-free-standing nature of SLG and robust magnetism of CFGG at the SLG/CFGG interface are revealed through depth-resolved X-ray magnetic circular dichroism spectroscopy. Density functional theory (DFT) calculation results indicate that the inherent electronic properties of SLG and CFGG such as the linear Dirac band and half-metallic band structure are preserved in the vicinity of the interface. These exciting findings suggest that the SLG/CFGG heterostructure possesses distinctive advantages over other reported graphene/ferromagnet heterostructures, for realizing effective transport of highly spin-polarized electrons in graphene-based vertical SV and other advanced spintronic devices. | Li, Songtian; Larionov, Konstantin V.; Popov, Zakhar I.; Watanabe, Takahiro; Amemiya, Kenta; Entani, Shiro; Avramov, Pavel V.; Sakuraba, Yuya; Naramoto, Hiroshi; Sorokin, Pavel B.; Sakai, Seiji | Natl Inst Quantum & Radiol Sci & Technol QST, Quantum Beam Sci Directorate, 1233 Watanuki, Takasaki, Gumma 3701292, Japan; Natl Inst Quantum & Radiol Sci & Technol QST, Adv Study Lab, Inage Ku, 4-9-1 Anagawa, Chiba 2638555, Japan; Natl Univ Sci & Technol MISiS, Lab Inorgan Nanomat, 4 Leninskiy Prospect, Moscow 119049, Russia; Moscow Inst Phys & Technol, 9 Inst Skii Per, Dolgoprudnyi 141700, Moscow Region, Russia; Emanuel Inst Biochem Phys RAS, 4 Kosygina St, Moscow 119334, Russia; High Energy Accelerator Res Org KEK, Inst Mat Struct Sci, Photon Factory, 1-1 Oho, Tsukuba, Ibaraki 3050801, Japan; Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Daegu 702701, South Korea; NIMS, Res Ctr Magnet & Spintron Mat, 1-2-1 Sengen, Tsukuba, Ibaraki 3050047, Japan | Sorokin, Pavel/C-9749-2011; Li, Songtian/S-5628-2019; Sakuraba, Yuya/C-1902-2009; Larionov, Konstantin/F-3855-2017; Popov, Zakhar/E-2879-2014 | 56151262900; 57201297064; 49061336400; 55700170300; 58865272400; 6602217127; 7004322420; 24339599500; 56212525200; 9277558700; 57235274600 | li.songtian@qst.go.jp;pbsorokin@misis.ru; | ADVANCED MATERIALS | ADV MATER | 0935-9648 | 1521-4095 | 32 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 30.849 | 2.2 | 1.2 | 2025-06-25 | 21 | 21 | electronic and magnetic properties; graphene; graphene spintronics; half-metallic Heusler alloys; interfacial bonding | SPIN POLARIZATION; RAMAN-SPECTROSCOPY; ROOM-TEMPERATURE; MAGNETORESISTANCE; SINGLE; INTERFACES; LIFETIMES; TRANSPORT | electronic and magnetic properties; graphene; graphene spintronics; half-metallic Heusler alloys; interfacial bonding | Chemical bonds; Chemical vapor deposition; Circular dichroism spectroscopy; Density functional theory; Dichroism; Electronic properties; Graphene devices; Magnetoresistance; Spintronics; Electronic and magnetic properties; Half metallic band structure; Heusler alloys; Interfacial bonding; Magnetoresistance effects; Spin dependent electronics; Ultra high vacuum chemical vapor deposition; X-ray magnetic circular dichroism; Graphene | English | 2020 | 2020-02 | 10.1002/adma.201905734 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Microbial Polyhydroxyalkanoates and Nonnatural Polyesters | Microorganisms produce diverse polymers for various purposes such as storing genetic information, energy, and reducing power, and serving as structural materials and scaffolds. Among these polymers, polyhydroxyalkanoates (PHAs) are microbial polyesters synthesized and accumulated intracellularly as a storage material of carbon, energy, and reducing power under unfavorable growth conditions in the presence of excess carbon source. PHAs have attracted considerable attention for their wide range of applications in industrial and medical fields. Since the first discovery of PHA accumulating bacteria about 100 years ago, remarkable advances have been made in the understanding of PHA biosynthesis and metabolic engineering of microorganisms toward developing efficient PHA producers. Recently, nonnatural polyesters have also been synthesized by metabolically engineered microorganisms, which opened a new avenue toward sustainable production of more diverse plastics. Herein, the current state of PHAs and nonnatural polyesters is reviewed, covering mechanisms of microbial polyester biosynthesis, metabolic pathways, and enzymes involved in biosynthesis of short-chain-length PHAs, medium-chain-length PHAs, and nonnatural polyesters, especially 2-hydroxyacid-containing polyesters, metabolic engineering strategies to produce novel polymers and enhance production capabilities and fermentation, and downstream processing strategies for cost-effective production of these microbial polyesters. In addition, the applications of PHAs and prospects are discussed. | Choi, So Young; Cho, In Jin; Lee, Youngjoon; Kim, Yeo-Jin; Kim, Kyung-Jin; Lee, Sang Yup | Korea Adv Inst Sci & Technol, Metab & Biomol Engn Natl Res Lab, Syst Metab Engn & Syst Healthcare Cross Generat C, Dept Chem & Biomol Engn,BK21 Plus Program,Inst Bi, 291 Daehak Ro, Daejeon 34141, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Sch Life Sci, KNU Creat BioRes Grp, 80 Daehak Ro, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, BioProc Engn Res Ctr, 291 Daehak Ro, Daejeon 34141, South Korea; Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, 291 Daehak Ro, Daejeon 34141, South Korea | Lee, Sang Yup/C-1526-2011; Kim, Kyung-Jin/MVY-3405-2025; Cho, In Jin/GRR-6433-2022 | 57212253133; 57193924251; 57209008159; 57203809529; 55510867400; 57193960263 | leesy@kaist.ac.kr; | ADVANCED MATERIALS | ADV MATER | 0935-9648 | 1521-4095 | 32 | 35 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 30.849 | 2.2 | 1.18 | 2025-06-25 | 130 | 130 | bacterial polyesters; metabolic engineering; microorganisms; plastics; polyhydroxyalkanoates | MEDIUM-CHAIN-LENGTH; RECOMBINANT ESCHERICHIA-COLI; POLY-BETA-HYDROXYBUTYRATE; RALSTONIA-EUTROPHA H16; IN-VITRO EVOLUTION; FED-BATCH CULTURE; INTRACELLULAR 3-HYDROXYBUTYRATE-OLIGOMER HYDROLASE; PSEUDOMONAS-PUTIDA KT2440; CELL-DENSITY CULTIVATION; UNRELATED CARBON-SOURCES | bacterial polyesters; metabolic engineering; microorganisms; plastics; polyhydroxyalkanoates | Biotechnology; Fermentation; Metabolic Engineering; Microbiology; Polyesters; Polyhydroxyalkanoates; Biochemistry; Biosynthesis; Carbon; Chain length; Cost effectiveness; Cost engineering; Genes; Metabolic engineering; Metabolism; Microorganisms; Scaffolds; polyester; polyhydroxyalkanoic acid; Cost-effective production; Downstream-processing; Genetic information; Microbial polyesters; Polyhydroxyalkanoates; Production capabilities; Short chain lengths; Sustainable production; biosynthesis; biotechnology; fermentation; metabolic engineering; metabolism; microbiology; Polyesters | English | 2020 | 2020-09 | 10.1002/adma.201907138 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Quantum Dots of [Na4Cs6PbBr4]⁸⁺, Water Stable in Zeolite X, Luminesce Sharply in the Green | Nanocrystals (NCs) of CsPbX3, X = Cl, Br, or I, have excellent photoluminescent properties: high quantum yield, tunable emission wavelengths (410-700 nm), and narrow emission band widths. CsPbBr3NCs show high promise as a green-emitting material for use in wide color gamut displays. CsPbBr3NCs have, however, not been commercialized because they are sensitive to moisture and heat. To avoid these problems, this work attempts to introduce CsPbBr(3)into five zeolites. The zeolite X product, Pb,Br,H,Cs,Na-X, shows superior stability toward moisture, maintaining its initial luminescence properties after being under water for more than a month. Its structure, determined using single-crystal X-ray crystallography, shows that quantum dots (QDs) of [Na4Cs6PbBr4](8+)(not of CsPbBr3) have formed. They are tetrahedral PbBr(4)(2-)ions (Pb-Br = 3.091(11) angstrom) surrounded by Na(+)and Cs(+)ions. Each fills the zeolite's supercage with its Pb(2+)ion precisely at the center, a position of high symmetry. The peaks in the emission spectra of Pb,Br,H,Cs,Na-X and the CsPbBr3NCs are both at about 520 nm. The FWHM of Pb,Br,H,Cs,Na-X, however, is narrower than any previously reported for any of the CsPbBr3NCs, and for zeolite Y and the various mesoporous materials treated with CsPbBr3. | Kim, Joon Young; Shim, Kyu In; Han, Jeong Woo; Joo, Jin; Heo, Nam Ho; Seff, Karl | Kyungpook Natl Univ, Dept Appl Chem, Sch Appl Chem Engn, Coll Engn, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 37673, South Korea; Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 37673, South Korea; Univ Hawaii, Dept Chem, 2545 Mall, Honolulu, HI 96822 USA | Han, Jeong Woo/D-3369-2011 | 57280808300; 57217425216; 55728845800; 57189617034; 17136916900; 7004839105 | nhheo@knu.ac.kr; | ADVANCED MATERIALS | ADV MATER | 0935-9648 | 1521-4095 | 32 | 34 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 30.849 | 2.2 | 0.99 | 2025-06-25 | 19 | 19 | green-emitting materials; lead bromide; luminescence; quantum dots; zeolite X | DEPENDENT STOKES SHIFT; FAUJASITE ZEOLITES; PEROVSKITE; EFFICIENT; NANOCRYSTALS; BRIGHT; OPPORTUNITIES; CRYSTAL; BR; CL | green-emitting materials; lead bromide; luminescence; quantum dots; zeolite X | Bromine compounds; Chlorine compounds; Crystal structure; Emission spectroscopy; Ions; Luminescence; Mesoporous materials; Moisture; Nanocrystals; Semiconductor quantum dots; Single crystals; Sodium compounds; X ray crystallography; Zeolites; Emission spectrums; Green-emitting materials; Luminescence properties; Nanocrystal (NCs); Narrow emission bands; Photo-luminescent properties; Single crystal X-ray crystallography; Tunable emissions; Lead compounds | English | 2020 | 2020-08 | 10.1002/adma.202001868 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sensitive Wearable Temperature Sensor with Seamless Monolithic Integration | Accurate temperature field measurement provides critical information in many scientific problems. Herein, a new paradigm for highly sensitive, flexible, negative temperature coefficient (NTC) thermistor-based artificial skin is reported, with the highest temperature sensing ability reported to date among previously reported NTC thermistors. This artificial skin is achieved through the development of a novel monolithic laser-induced reductive sintering scheme and unique monolithic structures. The unique seamless monolithic structure simultaneously integrates two different components (a metal electrode and metal oxide sensing channel) from the same material at ambient pressure, which cannot be achieved by conventional heterogeneous integration through multiple, complex steps of photolithography or vacuum deposition. In addition to superior performance, electronic skin with high temperature sensitivity can be fabricated on heat-sensitive polymer substrates due to the low-temperature requirements of the process. As a proof of concept, temperature-sensitive artificial skin is tested with conformally attachable physiological temperature sensor arrays in the measurement of the temperatures of exhaled breath for the early detection of pathogenic progression in the respiratory system. The proposed highly sensitive flexible temperature sensor and monolithic selective laser reductive sintering are expected to greatly contribute to the development of essential components in various emerging research fields, including soft robotics and healthcare systems. | Shin, Jaeho; Jeong, Buseong; Kim, Jinmo; Vu Binh Nam; Yoon, Yeosang; Jung, Jinwook; Hong, Sukjoon; Lee, Habeom; Eom, Hyeonjin; Yeo, Junyeob; Choi, Joonhwa; Lee, Daeho; Ko, Seung Hwan | Seoul Natl Univ, Dept Mech Engn, Appl Nano & Thermal Sci Lab, 1 Gwanak Ro, Seoul 08826, South Korea; Gachon Univ, Dept Mech Engn, Laser & Thermal Engn Lab, 1342 Seongnamdaero, Seongnam 13120, Gyeonggi, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, South Korea; Pusan Natl Univ, Sch Mech Engn, 2 Busandaehag Ro,63 Beon Gil, Busan 46241, South Korea; Korea Inst Ind Technol, Thermochem Energy Syst R&D Grp, 89 Yangdaegiro Gil, Cheonan Si 31056, Chungcheongnam, South Korea; Kyungpook Natl Univ, Dept Phys, 80 Daehak Ro, Daegu 41566, South Korea | ; Ko, Seung Hwan/B-5448-2008; Vu, Nam/KYR-1327-2024; Lee, Daeho/M-2734-2017; Yeo, Junyeob/I-1287-2013; Lee, Habeom/JVZ-8754-2024; Ko, Seung Hwan/B-5448-2008 | 58732445000; 57211665131; 57192317865; 56516595400; 57193443716; 57193111722; 34973077200; 55356379900; 36602348200; 58692645200; 57211667030; 56228667700; 8699527700 | dhl@gachon.ac.kr;maxko@snu.ac.kr; | ADVANCED MATERIALS | ADV MATER | 0935-9648 | 1521-4095 | 32 | 2 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 30.849 | 2.2 | 15.49 | 2025-06-25 | 382 | 372 | electronic skin; epidermal sensors; laser direct writing; monolithic sensors; temperature sensors | THIN-FILMS; THERMISTOR; TRANSPARENT; POWDERS; FABRICATION; CONDUCTOR; CERAMICS; PRESSURE; TACTILE; ARRAY | electronic skin; epidermal sensors; laser direct writing; monolithic sensors; temperature sensors | Mechanical Phenomena; Skin, Artificial; Temperature; Wearable Electronic Devices; Artificial organs; Metals; Monolithic integrated circuits; Respiratory system; Selective laser sintering; Sintering; Substrates; Temperature; Temperature sensors; Thermistors; Electronic skin; Heat sensitive polymers; Heterogeneous integration; High temperature sensitivity; Laser direct writing; Monolithic sensors; Physiological temperature; Temperature field measurements; artificial skin; electronic device; mechanics; temperature; Wearable sensors | English | 2020 | 2020-01 | 10.1002/adma.201905527 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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