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| ○ | ○ | Article | Learning About Different Models of Theory Change Using an Adapted Mystery Tube Activity in Science Teacher Education | The importance of the philosophy of science in science teacher education has long been argued for by science educators. In particular, understanding how scientific knowledge is generated, negotiated, and developed is a key area of the philosophy of science that is relevant to science teaching. However, research on the nature of scientific knowledge in science education has primarily focused on how it is constructed rather than how it is revised and developed through social processes. In this study, we adapted the classic "mystery tube" activity by including additional steps in which initial hypotheses are discussed and revised in groups, to help preservice science teachers (PSTs) understand the models of theory change proposed by Karl Popper, Thomas Kuhn, and Imre Lakatos. The study participants included 41 undergraduate PSTs from a South Korean university. Activity worksheets, end-of-term reports, and group discussion recordings were analyzed qualitatively to determine how participants related the Popperian, Kuhnian, and Lakatosian models of theory change to their own experiences of theory construction and revision. The findings show that the participants could identify key features of each model when explaining various aspects of the activity. It is also suggested that the activity was beneficial to the participants in understanding different models of theory change in philosophy of science. We discuss the implications of designing and implementing mystery tube activities to teach topics in philosophy of science in preservice science teacher education. | Ha, Sangwoo | Kyungpook Natl Univ, Dept Phys Educ, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sci Educ Res Inst, 80 Daehakro, Daegu 41566, South Korea | 55215468100 | hswgcb@knu.ac.kr; | SCIENCE & EDUCATION | SCI EDUC-NETHERLANDS | 0926-7220 | 1573-1901 | 34 | 1 | SSCI;AHCI;SCIE | EDUCATION & EDUCATIONAL RESEARCH;HISTORY & PHILOSOPHY OF SCIENCE | 2024 | 2.5 | 8.5 | 0 | 2025-05-07 | 0 | 0 | Mystery tube activity; Nature of scientific knowledge; Science teacher education; Models of theory change | CONCEPTIONS; STUDENTS; VIEWS; CLASSROOM; INQUIRY | Models of theory change; Mystery tube activity; Nature of scientific knowledge; Science teacher education | English | 2025 | 2025-02 | 10.1007/s11191-023-00455-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Modified Triplet-Average Deep Deterministic Policy Gradient for interpretable neuro-fuzzy deep reinforcement learning | In order to find the control rules of the nonlinear system from the learned data, it is necessary to interpret the learned policy in Deep Reinforcement Learning (DRL). This paper presents a novel interpretable Neuro-Fuzzy (NF) inference system based on Modified Triplet-Average Deep Deterministic Policy Gradient (MTADD) reinforcement learning algorithm with a two-phased training method. The first phase involves exploring and initiating the T-S fuzzy system rule and premise parameter. The second step is the deep reinforcement learning of the NF policy network, which uses a Modified Triplet-Average Deep Deterministic policy gradient algorithm. The experiment results demonstrate that the proposed approach decreases the training time, enhances the control performance, and increases the interpretability of NF DRL. | Nguyen, Tuan-Linh; Thin, Nguyen Van; Lee, Sangmoon | Thai Nguyen Univ Technol, Fac Elect Engn, Tich Luong ward, Thai Nguyen City, Vietnam; Thai Nguyen Univ Educ, Dept Math, Luong Ngoc Quyen St, Thai Nguyen City, Vietnam; Kyungpook Natl Univ, Sch Elect & Elect Engn, Cyber Phys Syst & Control Lab, Daehak Ro 80, Daegu, South Korea | Nguyen, Tuan-Linh/AAJ-4084-2021; Thin, Nguyen/AAS-7171-2021; Lee, Sangmoon/C-4502-2018 | 57754841100; 59034293800; 59510733500 | thinnv@tnue.edu.vn; moony@knu.ac.kr; | JOURNAL OF THE FRANKLIN INSTITUTE | J FRANKLIN I | 0016-0032 | 1879-2693 | 362 | 7 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | 2024 | 4.2 | 8.5 | 0 | 2025-05-07 | 0 | 0 | Interpretable neuro-fuzzy controller; Two-phase training; Reinforcement learning; Twin-delay; Inverted pendulum | SYSTEMS; MODEL; DESIGN | Interpretable neuro-fuzzy controller; Inverted pendulum; Reinforcement learning; Twin-delay; Two-phase training | Adversarial machine learning; Contrastive Learning; Fuzzy neural networks; Inverted pendulum; Reinforcement learning; Deterministics; Interpretable neuro-fuzzy controller; Inverted pendulum; Neuro-Fuzzy; Neurofuzzy controllers; Policy gradient; Reinforcement learnings; Twin-delay; Two phase; Two-phase training; Deep reinforcement learning | English | 2025 | 2025-05-01 | 10.1016/j.jfranklin.2025.107653 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios | The biofunctionalization of sensor surfaces to enable biorecognition capabilities remains a major challenge in developing diagnostic devices. However, efficient surface chemistries applicable to various sensor types remain elusive. In this study, Primary Layer for Universal Sensing (PLUS), a universal coating for bioprobe immobilization designed to enhance sensor functionality across diverse substrates, is introduced. Derived from the mussel-inspired, catechol-based adhesive polydopamine (pDA), PLUS ensures material-independent coating ability. Unlike conventional methods that involve secondary bioprobe immobilization onto a pre-formed pDA layer, PLUS is directly grown from dopamine (DA) and avidin proteins as co-polymerization precursors, resulting in a highly roughened surface with abundant biotin-binding sites. This strategy, combined with end-functionalization using biotinylated antibodies, significantly enhances immunocapture efficiency compared to traditional immunoassays. Furthermore, the PLUS layer interacts effectively with blocking proteins, preventing non-specific binding of unwanted molecules. This ensures reliable biomarker capture even in complex biological samples, such as 50% human serum and plasma. It is envisioned that this bioprobe immobilization technique will play a pivotal role in advancing high-performance sensor adaptability for molecular diagnostics. © 2025 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. | Son, Nayoung; Byeon, Chorok; Jeong, Haejin; Jang, Hyeonha; Park, Jun Seok; Hong, Seonki | Department of Physics and Chemistry, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea; Department of Physics and Chemistry, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea; Department of Physics and Chemistry, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea; Medical Research Center, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea, Department of Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Physics and Chemistry, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea | 59966420700; 58964313700; 57841409100; 57218761651; 35226761100; 37461264400 | seonkihong@dgist.ac.kr; | Advanced Healthcare Materials | ADV HEALTHC MATER | 2192-2640 | 2192-2659 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 9.6 | 8.5 | 0 | antibody immobilization; avidin-biotin interaction; biorecognition; biosensing; polydopamine | Biomarkers; Coatings; Diagnosis; Glycoproteins; Neurophysiology; Proteins; Radioactive waste vitrification; Surface chemistry; Antibody immobilization; Avidin-biotin; Avidin-biotin interaction; Biofunctionalization; Bioprobe; Biorecognition; Biosensing; Immobilisation; Immunocapture; Polydopamine; Binding sites | English | Article in press | 2025 | 10.1002/adhm.202501281 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells | Replicating the complex mechanical forces of muscle movement and fluid flow in in vitro cell culture systems is crucial for understanding cell differentiation and development. However, previous research focused on cell differentiation on static micro/nanotextures without a force field or flat 2-dimensional substrates under a continuous in-plane mechanical force. In this study, cell differentiation is reported using a spatial geometric platform that can periodically modulate complex mechanical forces through a custom-made soft pneumatic device (SPD) to mimic the interfaces between periosteum and interstitial fluid. To elucidate fluidic dynamics and cell fates relevant to bone physiology, the platform exhibited distinct functional responses based on mechanical force levels: low mechanotransduction induced mesenchymal stem/progenitor cells differentiation into osteoprogenitor cells (approximate to 1.5-fold increase in osteo-differentiation), while high mechanotransduction resulted in structural disruptions resembling cell detachment without protein degradation (approximate to 2-fold increase in effective cell detachment). Numerical simulations of SPD elucidated the principal mechanical components for programmable cell differentiation and detachment by deconvoluting the in-plane and out-of-plane mechanical forces of the SPD complex mode. This study offers comprehensive and novel insights into the correlation between mechanical forces and cell differentiation, recovery, and injury in organisms. | Im, Gwang-Bum; Lee, Jae Gyeong; Lim, Hosub; Lee, Jae-Won; Park, Hyun Su; Kim, Yongju; Asad, Nauman; Kim, Hak-Rin; Wie, Jeong Jae; Bhang, Suk Ho | Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, South Korea; Hanyang Univ, Dept Organ & Nano Engn, Seoul 04763, South Korea; Hanyang Univ, Human Tech Convergence Program, Seoul 04763, South Korea; Harvard Med Sch, Brigham Womens Hosp, Div Engn Med, Dept Med,Brigham & Womens Hosp, Boston, MA 02115 USA; Harvard Med Sch, Brigham Womens Hosp, Dept Med, Renal Div, Boston, MA 02114 USA; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Inha Univ, Dept Polymer Sci & Engn, Incheon 22212, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Hanyang Univ, Res Inst Ind Sci, Seoul 04763, South Korea; Hanyang Univ, Dept Chem Engn, Seoul 04763, South Korea; Hanyang Univ, Inst Nano Sci & Technol, Seoul 04763, South Korea; SUNY, Dept Chem Engn, Coll Environm Sci & Forestry, Syracuse, NY 13210 USA; SUNY, Michael M Szwarc Polymer Res Inst, Coll Environm Sci & Forestry, Syracuse, NY 13210 USA; Harvard Med Sch, Dept Surg, Boston, MA 02115 USA | Lim, Hosub/MTG-5804-2025; Kim, Byung-Soo/O-2352-2013; Wie, Jeong Jae (JJ)/I-9878-2019; Kim, Hak-Rin/T-1897-2019 | 57200788425; 57217492620; 59705306100; 58377059800; 57445555600; 57215782098; 59705306200; 7410124944; 26041261000; 14057699000 | jjwie@hanyang.ac.kr; sukhobhang@skku.edu; | ADVANCED HEALTHCARE MATERIALS | ADV HEALTHC MATER | 2192-2640 | 2192-2659 | 14 | 15 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 9.6 | 8.5 | 0 | 2025-05-07 | 0 | 0 | MSC; osteogenesis; periosteum; soft materials | FLUID SHEAR-STRESS; BONE ADAPTATION; TISSUE; MATRIX; DIFFERENTIATION; STIMULATION; REVEALS; STRAIN; FORCES; PIEZO1 | MSC; osteogenesis; periosteum; soft materials | Animals; Cell Culture Techniques; Cell Differentiation; Humans; Mechanotransduction, Cellular; Mesenchymal Stem Cells; Osteogenesis; Periosteum; Continuous cell culture; Muscle; Physiological models; Pneumatic tools; Pneumatics; Tissue culture; alkaline phosphatase; collagen type 1; CX43 protein; fibronectin; peptides and proteins; peroxisome proliferator activated receptor gamma; PIEZO1 protein; PIEZO2 protein; transcription factor RUNX2; transcription factor Sox9; unclassified drug; Cell detachment; Cell differentiation; Mechanical force; Mechanotransduction; Mesenchymal stem cell; MSC; Osteogenesis; Periosteum; Pneumatic devices; Softer materials; Article; biomechanics; bone development; cell adhesion; cell differentiation; cell growth; cell viability; controlled study; density; extracellular matrix; fluidics; fluorescence microscopy; gene expression; genetic analysis; human; human cell; hydrophilicity; immunocytochemistry; immunofluorescence assay; immunohistochemistry; interstitial fluid; laminar flow; mechanotransduction; mesenchymal stem cell; muscle contraction; osteoprogenitor cell; periosteum; protein degradation; protein expression; real time polymerase chain reaction; shear stress; simulation; upregulation; velocity; viscosity; Young modulus; animal; cell culture technique; cell differentiation; cytology; devices; metabolism; periosteum; Stem cells | English | 2025 | 2025-06 | 10.1002/adhm.202403229 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Synthesis of sulfur and bromine co-doped bentonite-chitosan composite hydrogels for selective adsorption of cobalt and strontium radionuclides | The present study focuses on the synthesis of sulfur (S) and bromine (Br) co-doped bentonite and its threedimensional chitosan composite hydrogels (S/Br-B-CB-x) for the selective removal of hazardous radiotoxic pollutants, specifically the radionuclides 60Co and 85,90Sr. The physicochemical properties of the synthesized materials were analyzed using various characterization techniques. Batch adsorption studies for 60Co and 85,90Sr were conducted under batch mode to evaluate the adsorption performance of the prepared materials. The influence of key parameters such as contact time, solution pH, adsorbent mass, temperature, and coexisting anions was systematically examined to determine the maximum adsorption efficiency. The adsorption of 60Co and 85,90Sr onto S/Br-B-CB-50 followed pseudo-second-order kinetics and aligned with the Langmuir adsorption isotherm, indicating a chemisorption mechanism governed by monolayer formation. Regeneration experiments revealed that S/Br-B-CB-50 maintained excellent adsorption efficiency for 60Co and 85,90Sr over five consecutive cycles, demonstrating the high stability of the materials. The outstanding adsorption performance of the hydrogels can be attributed to several mechanisms, including electrostatic interactions, ion exchange, surface complexation, and the principles of the hard and soft acids and bases theory. These results confirm that S/Br-B-CB-50 is an effective adsorbent for removing 60Co and 85,90Sr, highlighting its potential for the remediation of liquid radioactive waste. | Cha, Byungjun; Elanchezhiyan, S. S. D.; Saravanakumar, Karunamoorthy; Jagan, Govindan; Njaramba, Lewis Kamande; Jang, Min; Yoon, Yeomin; Park, Chang Min | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Velammal Coll Engn & Technol, Dept Chem, Madurai 625009, Tamil Nadu, India; Kwangwoon Univ, Dept Environm Engn, Seoul 01897, South Korea; Kwangwoon Univ, Plasma Biosci Res Ctr, Seoul 01897, South Korea; Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea | Kamande, Lewis/JLL-5435-2023; Park, Chang Min/CAA-8506-2022 | 57337280900; 54894383700; 57223020778; 57885044400; 57223183206; 36762550700; 7402126688; 57209588953 | minjang@kw.ac.kr; yoony@ewha.ac.kr; cmpark@knu.ac.kr; | JOURNAL OF NUCLEAR MATERIALS | J NUCL MATER | 0022-3115 | 1873-4820 | 614 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 3.2 | 8.5 | 0 | 2025-06-11 | 0 | 0 | Sulfur; Bromine; Bentonite; Chitosan; Radionuclide; Sulfur; Bromine; Bentonite; Chitosan; Radionuclide | FT-IR; INNER-SPHERE; METAL-IONS; WASTE; TRANSPORT; HYDRATION; STATE; FILMS; CLAY; XPS | Bentonite; Bromine; Chitosan; Radionuclide; Sulfur | Adsorption isotherms; Bioremediation; Ion bombardment; Adsorption efficiency; Adsorption performance; Characterization techniques; Chitosan composites; Co-doped; Composite hydrogels; Physicochemical property; Selective adsorption; Selective removal; Synthesized materials; Radioactive wastes | English | 2025 | 2025-08 | 10.1016/j.jnucmat.2025.155917 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Thermoforming 2D films into 3D electronics for high-performance, customizable tactile sensing | The demand for tactile sensors in robotics, virtual reality, and health care highlights the need for high performance and customizability. Despite advances in vision-based technologies, tactile sensing remains crucial for precise interaction and subtle pressure detection. In this work, we present a design and fabrication method of customizable tactile sensors based on thermoformed three-dimensional electronics. This approach enables ultrawide modulus tunability (10 pascals to 1 megapascal) and superior mechanical properties, including negligible hysteresis and high creep resistance. These features allow the sensor to detect a broad spectrum of pressures, from acoustic waves to body weight, with high performance. The proposed sensors have high sensitivity (up to 5884 per kilopascal), high linearity (R2 = 0.999), low hysteresis (<0.5%), and fast response (0.1 milliseconds). We demonstrate applications in human-computer interaction and health care, showcasing their potential in various fields. This platform provides a scalable solution for fabricating versatile, high-performance tactile sensors. | Choi, Jungrak; Han, Chankyu; Lee, Donho; Kim, Hyunjin; Lee, Gihun; Ha, Ji-Hwan; Jeong, Yongrok; Ahn, Junseong; Park, Hyunkyu; Han, Hyeonseok; Cho, Seokjoo; Gu, Jimin; Park, Inkyu | Korea Adv Inst Sci & Technol KAIST, Dept Mech Engn, 291 Daehak ro, Daejeon 34141, South Korea; Elect & Telecommun Res Inst ETRI, Daejeon 34129, South Korea; Hanbat Natl Univ, Dept Mech Engn, Daejeon 34158, South Korea; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea; Korea Univ, Dept Control & Instrumentat Engn, Sejong 30019 21, South Korea; Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA; Korea Adv Inst Sci & Technol KAIST, KAIST Inst KI NanoCentury, Daejeon 34141, South Korea | Ha, Ji-Hwan/KWL-4994-2024; Park, Inkyu/C-1717-2011; Ahn, Junseong/ISV-5478-2023 | 57210927486; 57295041300; 58937722200; 57215488253; 57219733094; 57226428762; 57193677342; 57209789129; 57194500636; 57218588092; 57229870800; 57202058947; 55721570100 | inkyu@kaist.ac.kr; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 11 | 20 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 12.5 | 8.5 | 0 | 2025-06-11 | 0 | 0 | PRESSURE SENSORS | 3-D electronics; Customizability; Customizable; Design method; Fabrication method; Performance; Pressure detections; Tactile sensing; Tactile sensors; Vision based; article; body weight; controlled study; electronics; human; human computer interaction; hysteresis; male; pressure; robotics; sensor; virtual reality; Creep | English | 2025 | 2025-05-14 | 10.1126/sciadv.adv0057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Variation in multi-unit NPP seismic risk due to seismic failure correlation between structures, systems, and components (SSCs) | Seismic events affect a wide area; therefore, if such an event occurs at nuclear power plants on the same site, the impact will be similar. This correlation in seismic failure extends across structures, systems, and components (SSCs). This study performed a seismic probabilistic risk assessment for multi-units, incorporating the seismic failure correlations between SSCs, and investigated the variation in risk due to these correlations. The seismic failure correlation coefficients between SSCs were derived from probabilistic seismic response analyses. Furthermore, for comparative analysis, the seismic risk was assessed using the seismic failure correlation between SSCs for independence, partial dependence, and complete dependence. A partially dependent case for the same component was also investigated. The findings indicate significant variations in the seismic fragility and seismic risk of nuclear power plants when considering failure correlations between SSCs, highlighting the importance of including such interdependencies between SSCs in safety evaluations for multi-unit scenarios. This study provides insights for enhancing the seismic probability risk assessment of nuclear power plants, especially in areas with multi-unit issues. | Eem, Seunghyun; Park, Jin Hee; Choi, In-kil; Kwag, Shinyoung | Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Major Plant Syst Engn, Daegu 41566, South Korea; Korea Atom Energy Res Inst, Risk Assessment Res Div, Daejeon 34057, South Korea; Korea Atom Energy Res Inst, Struct & Seismic Safety Res Div, Daejeon 34057, South Korea; Hanbat Natl Univ, Dept Civil & Environm Engn, Daejeon 34158, South Korea | 52363442900; 54402165900; 36118722100; 55779491500 | eemsh@knu.ac.kr; jhpark6@kaeri.re.kr; cik@kaeri.re.kr; skwag@hanbat.ac.kr; | PROGRESS IN NUCLEAR ENERGY | PROG NUCL ENERG | 0149-1970 | 1878-4224 | 187 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 3.2 | 8.5 | 0 | 2025-06-11 | 0 | 0 | Nuclear power plant; Multi-unit; Seismic; Correlation; Fragility; Risk | PROBABILISTIC SAFETY ASSESSMENT | Correlation; Fragility; Multi-unit; Nuclear power plant; Risk; Seismic | Earthquake effects; Nuclear fuel elements; Nuclear reactor accidents; Risk analysis; Seismic response; Correlation; Failure correlation; Fragility; Multi-unit; Power; Seismic; Seismic event; Seismic risk; Structure component; Structure systems; Risk assessment | English | 2025 | 2025-09 | 10.1016/j.pnucene.2025.105851 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Developing the rice ideotype: Optimizing traits for methane mitigation and sustainable yield | Rice is a staple food for billions of people but also a major source of methane emissions, contributing approximately 10% of global agricultural methane. Therefore, this study aimed to conduct a correlation analysis of various traits gathered from years of research on the 120 Cheongcheong Nagdong Double Haploid (CNDH) population to identify key traits responsible for methane emission in rice. This study focused on practical plant traits, including culm length, spikelets per panicle, and grain weight, which have a positive correlation with methane emission. Shorter culm lengths produce less biomass, thereby reducing the organic matter available to feed methane-producing microbes. Increasing the number of spikelets per panicle increase boosts grain production, thereby reducing the development of root exudates that contribute to methane production. Our results indicate a positive correlation (r = 0.51) between grain weight and methane emissions, suggesting that selecting for heavier grains may actually increase methane emissions. Based on these features, we propose an rice ideotype variety that possibly minimizes the rice plant methane emissions while maintaining a high yield. This paper suggests that future studies should be extended to validate these current findings and explore the genetic components and ecological aspects of methane emissions to improve methane management in sustainable rice farming systems. | Asif, Saleem; Jang, Yoon-Hee; Jan, Rahmatullah; Asaf, Sajjad; Lubna, Eun-Gyeong; Kim, Eun-Gyeong; Park, Jae-Ryoung; Kim, Kyung-Min | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; RDA, Gene Engn Div, Natl Inst Agr Sci, Jeonju 54874, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman; Rural Dev Adm, Natl Acad Agr Sci, Natl Agrobiodivers Ctr, Jeonju 54874, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wanju 55365, South Korea | Asaf, Sajjad/ABA-3647-2021; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/LFU-1421-2024 | 57396413700; 57219901992; 57201981969; 56595059900; 57200621537; 57221496070; 57211205505; 34868260300 | kkm@knu.ac.kr; | PLANT JOURNAL | PLANT J | 0960-7412 | 1365-313X | 121 | 5 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 0 | 2025-05-07 | 0 | 0 | culm length; grain weight; methane emission; rice; rice ideotype; spikelets per panicle | EMISSION; PADDY; CULTIVARS; FIELDS | culm length; grain weight; methane emission; rice; rice ideotype; spikelets per panicle | Correlation; Culm; Grain; Increments; Methane; Production; Rice; Weight; Biomass; Methane; Oryza; Phenotype; Grain (agricultural product); Low emission; methane; Culm length; Grain weights; Methane emissions; Methane mitigation; Positive correlations; Rice; Rice ideotype; Spikelet per panicle; Staple food; Sustainable yields; biomass; genetics; growth, development and aging; metabolism; Oryza; phenotype | English | 2025 | 2025-03 | 10.1111/tpj.70087 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Differences in immune cells and gene expression in human milk by parity on integrated scRNA sequencing | Background: Human breast milk (HBM) is an important source of tolerogenic immune mediators that influence the infant immune system. HBM-derived immune com- ponents are affected by various factors; however, few studies have examined the relationship between parity and immune cell profiles of HBM. Purpose: This study aimed to clarify the effects of parity on HBM immune cell heterogeneity and gene expression by integrating and analyzing publicly available single-cell RNAsequencing (scRNA-seq) datasets. Methods: We clarified the effects of parity on HBM immune cell heterogeneity and gene expression by integrating and analyzing publicly available scRNA-seq datasets. Results: The proportion of innate immune cells was significantly higher in the primiparous versus multipa- rous group, whereas the proportion of adaptive immune cells was significantly higher in the multiparous group (P=0.021). The 2 immune clusters were reannotated and classified into monocyte, T/B cell, and CD45 groups. The proportions of monocytes and T/B cells were higher in the primiparous and multiparous groups, respectively. In a gene set enrichment analysis of monocytes, genes with a direct role in the infant immune system and immune response-related genes were more highly expressed in the primiparous group. Conclusion: Our results support the parity-dependent differences in gene expression between innate and adaptive immune cells. | Yi, Dae Yong; Park, Hong-Jai; Shin, Min Sun; Kim, Hyoungsu; Lee, Sang Jin; Kang, Insoo | Chung Ang Univ Hosp, Dept Pediat, 102 Heukseok Ro, Seoul 06973, South Korea; Chung Ang Univ, Coll Med, Seoul, South Korea; Yale Univ, Sch Med, Dept Internal Med, Sect Rheumatol Allergy & Immunol, New Haven, CT USA; Hallym Univ, Kangdong Sacred Heart Hosp, Sch Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Yi, Dae/G-1729-2014 | 57190851975; 56233299400; 56568662300; 7410129808; 59820086900; 7203062711 | meltemp2@hanmail.net; insoo.kang@yale.edu; | CLINICAL AND EXPERIMENTAL PEDIATRICS | CLIN EXP PEDIATR | 2713-4148 | 68 | 2 | ESCI | PEDIATRICS | 2024 | 3.6 | 8.6 | 0 | 2025-05-07 | 0 | 0 | Human milk; Single-cell RNA-seq; Parity | COLOSTRUM; MONOCYTES | Human milk; Parity; Single-cell RNA-seq | carbohydrate; cholesterol; fatty acid; protein; triacylglycerol; Article; breast milk; cluster analysis; differential gene expression; Embase; functional enrichment analysis; gene expression; gene ontology; gene set enrichment analysis; human; immune response gene; immune system; immunocompetent cell; macronutrient; Medline; monocyte; parity; principal component analysis; Scopus; search engine; single cell RNA seq; Web of Science | English | 2025 | 2025-02 | 10.3345/cep.2024.01585 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Integrated role of biochar and PGPR (Leclercia adecarboxylata HW04) in enhancing cadmium phytoremediation and stress tolerance in Glycine max L | Plant growth-promoting rhizobacteria (PGPR) and biochar (BC) are recognized as effective biological agents for enhancing stress tolerance and mitigating heavy metal toxicity in crops. Therefore, this study aims to investigate the effects of the cadmium (Cd)-resistant PGPR strain Leclercia adecarboxylata HW04 (>4 mM Cd resistance) on soybean plants exposed to 300 mu M Cd. HW04 was observed to possess the innate ability to synthesize indole-3-acetic acid and exopolysaccharides, which facilitated the absorption of Cd in the medium. Scanning electron microscopy (SEM) images revealed that HW04 effectively colonized the porous structure of BC. Their combined treatment significantly enhanced photosynthesis and improved the morphological characteristics of soybean plants. Additionally, the Cd content in soybean shoots significantly increased following both the sole or combined treatments of BC and HW04. However, the combined treatments significantly reduced Cd content in the roots and soil by 31% and 47%, respectively. HW04 inoculation alone increased Cd content in the roots by 43.7% while lowering it in the soil by 7.4%. Additionally, the co-application of HW04 and BC significantly enhanced calcium (Ca) and magnesium (Mg) assimilation while promoting Cd/Fe accumulation in soybean shoots. The higher expression of signaling cascade genes, including GmCaMK1 and GmCDPK5 (Ca signaling) and GmMAPK4a and GmMAPK7 (MAP kinase signaling), in the co-applied crops further validate the findings. The increase in abscisic acid levels and the decrease in salicylic acid levels after HW04 and BC application were correlated with enhanced stress tolerance in crops. These findings suggest that the combined application of HW04 and BC could serve as an effective, eco-friendly approach for mitigating heavy metal toxicity in crops and promoting phytoremediation. | Woo, Ji-In; Adhikari, Arjun; Gam, Ho-Jun; Jeon, Jin Ryeol; Lee, Da-Sol; Kwon, Eun-Hae; Kang, Sang-Mo; Yun, Byung-Wook; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | ; Kang, Sang-Mo/MBG-7823-2025; Adhikari, Arjun/AAV-6297-2021; Gam, Hojun/MXJ-6421-2025; Lee, In-Jung/GLS-0432-2022 | 58295960600; 57195601415; 57450591400; 58781998600; 57222624235; 57224398710; 56189696900; 8245123600; 16425830900 | ijlee@knu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 220 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 0 | 2025-05-07 | 1 | 3 | Biofertilizer; Cadmium exposure; Nutrients; Phytohormone; Soybean plant; Sustainable agriculture; Toxicity | DEPENDENT PROTEIN-KINASE; SALICYLIC-ACID; PLANT-GROWTH; OXIDATIVE STRESS; ARABIDOPSIS; RESPONSES; PHYTOHORMONES; ACCUMULATION; GIBBERELLINS; ADSORPTION | Biofertilizer; Cadmium exposure; Nutrients; Phytohormone; Soybean plant; Sustainable agriculture; Toxicity | Biodegradation, Environmental; Cadmium; Charcoal; Glycine max; Photosynthesis; Plant Roots; Soil Pollutants; Stress, Physiological; cadmium; charcoal; bioremediation; drug effect; metabolism; microbiology; photosynthesis; physiological stress; plant root; soil pollutant; soybean; toxicity | English | 2025 | 2025-03 | 10.1016/j.plaphy.2025.109489 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Physiological mechanisms of heavy metal detoxification in tomato plants mediated by endophytic fungi under nickel and cadmium stress | Heavy metal (HM) pollution in agricultural soils threatens plant growth and food security, underscoring the urgency for sustainable and eco-friendly solutions. This study investigates the potential of endophytic fungi, Fusarium proliferatum SL3 and Aspergillus terreus MGRF2, in mitigating nickel (Ni) and cadmium (Cd) stress in Solanum lycopersicum (tomato). These fungi were evaluated for their plant growth-promoting traits, including the production of indole-3-acetic acid (IAA) and siderophores, offering a sustainable strategy for alleviating HM toxicity. Inoculation with SL3 and MGRF2 significantly reduced metal accumulation in plant tissues by enhancing metal immobilization and modifying root architecture. Microscopic analysis revealed that fungi protected root epidermal cells from Ni- and Cd-induced damage, preserving cellular integrity and preventing plasmolysis. Fungal-treated plants exhibited improved growth and biomass, with SL3 demonstrating superior Cd stress mitigation and MGRF2 excelling under Ni stress. Photosynthetic pigment levels, including chlorophyll-a and carotenoids, were restored, highlighting the role of fungi in maintaining photosynthetic efficiency. Antioxidant activity was also modulated, as reduced glutathione (GSH) levels and increased flavonoid production were observed, contributing to enhanced oxidative stress management. Hormonal profiling revealed that fungal inoculation balanced stress-induced hormonal disruptions, with lower abscisic acid (ABA) levels and improved salicylic acid (SA) and gibberellic acid (GA) pathways. These changes facilitated better stress adaptation, enhanced nutrient uptake, and improved physiological performance. qRT-PCR analysis further revealed differential gene expression patterns, while antioxidant enzyme activity strengthened the plants' defense against HMinduced oxidative damage. Multivariate analyses highlighted shoot and root traits as critical indicators of resilience, with fungal inoculation driving substantial improvements. These findings demonstrate the potential of SL3 and MGRF2 as eco-friendly bioinoculants, offering a sustainable and cost-effective approach to reducing HMs toxicity in contaminated soils while enhancing crop productivity. This work highlights the promising role of plant-microbe interactions in advancing sustainable agriculture and addressing the challenges posed by heavy metal pollution. | Khan, Ibrahim; Asaf, Sajjad; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman | Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Khan, Ibrahim/JMC-5061-2023; Asaf, Sajjad/ABA-3647-2021 | 57191379139; 56595059900; 56189696900; 16425830900 | sajadasif2000@gmail.com; ijlee@knu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 221 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 7.89 | 2025-05-07 | 3 | 3 | Bioremediation; Tomato; Endophytes; HMs stress; Phytohormones; Antioxidants; Gene expression | PHASEOLUS-VULGARIS; GROWTH; LEAD; SALT; PHOTOSYNTHESIS; PHYTOTOXICITY; BIOSYNTHESIS; METABOLISM; RESISTANCE; REGULATORS | Antioxidants; Bioremediation; Endophytes; Gene expression; HMs stress; Phytohormones; Tomato | Aspergillus; Cadmium; Endophytes; Fusarium; Nickel; Plant Roots; Soil Pollutants; Solanum lycopersicum; Stress, Physiological; cadmium; nickel; Aspergillus; drug effect; endophyte; Fusarium; metabolism; microbiology; physiological stress; plant root; soil pollutant; tomato; toxicity | English | 2025 | 2025-04 | 10.1016/j.plaphy.2025.109589 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Review | Practical concepts and strategies for early diagnosis and management of eosinophilic gastrointestinal disorders in East-Asian children | Eosinophilic gastrointestinal disorders (EGIDs) are emerging as significant concerns in the Korean pediatric population and transitioning from rare to more commonly diagnosed conditions. This review discusses the increasing prevalence of EGID among children and adolescents and highlights the complexities involved in its diagnosis and management. This review begins with a thorough examination of the diverse clinical presentations of EGIDs in Korean children, with a special focus on common gastrointestinal symptoms such as abdominal pain, diarrhea, and bloody stool. Additionally, we explored extraintestinal manifestations, including growth failure, malnutrition, and associated allergic comorbidities, highlighting their importance in the clinical landscape of EGIDs. Because of its subtle and overlapping symptoms with those of other gastrointestinal disorders, EGID is frequently underdiagnos ed. Addressing this challenge requires maintaining a high index of suspicion and employing a com-prehensive diagnostic approach to differentiating EGID from functional gastrointestinal disorders and other inflammatory or systemic diseases such as inflammatory bowel disease. The optimal management of EGID requires a collaborative multidisciplinary strategy that includes dietary management, regular monitoring, and tailored medical interventions. This review emphasizes the importance of proactive patient and caregiver education and regular follow-ups to improve long-term outcomes in affected children. Enhanced awareness among healthcare providers and better educational resources for families are critical for the early identification and effective management of EGID among pediatric patients. © 2025 by The Korean Pediatric Society. | Choe, Byung-Ho | Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea | 57574977300 | bhchoi@knu.ac.kr; | Clinical and Experimental Pediatrics | CLIN EXP PEDIATR | N/A | 2713-4148 | 68 | 3 | ESCI | PEDIATRICS | 2024 | 3.6 | 8.6 | 0 | 2025-05-07 | 0 | Diagnosis; Eosinophilic gastrointestinal disorders; Guideline; Korean children; Non-EoE EGIDs | abdominal pain; adolescent; awareness; caregiver; child; comorbidity; diagnosis; diarrhea; digestive system function disorder; drug therapy; early diagnosis; East Asian; enteropathy; eosinophilic gastrointestinal disorder; follow up; gastrointestinal discomfort; gastrointestinal disease; growth disorder; health care personnel; hematochezia; human; inflammation; inflammatory bowel disease; Korean (people); malnutrition; melena; pediatric patient; prevalence; review; systemic disease; therapy | English | Final | 2025 | 10.3345/cep.2024.01165 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Retromer protein VPS29 plays a crucial and positive role in the sumoylation system mediated by E3 SUMO ligase SIZ1 | Vacuolar protein sorting 29 (VPS29) functions in retrograde protein transport as a component of the retromer complex. However, the role of VPS29 in the regulation of post-translational modifications, such as sumoylation and ubiquitination, has not been elucidated. In this study, we demonstrate that VPS29 positively regulates SIZ/PIAS-type E3 SUMO (Small ubiquitin-related modifier) ligase-mediated sumoylation systems. In Arabidopsis, vps29-3 mutants display upregulated salicylic acid (SA) signaling pathways and reactive oxygen species accumulation, similar to those observed in siz1 mutants. Arabidopsis VPS29 (AtVPS29) directly interacts with the Arabidopsis E3 SUMO ligase SIZ1 (AtSIZ1) and localizes not only to the cytoplasm but also to the nucleus. The loss of AtVPS29 leads to a depletion of AtSIZ1, whereas the E3 ubiquitin ligase constitutive photomorphogenic 1 (COP1), an upstream regulator of AtSIZ1, accumulates in vps29-3 mutants. Conversely, overexpression of AtVPS29 results in the accumulation of AtSIZ1 and the depletion of COP1 in transgenic Arabidopsis. Similarly, in human cells, silencing of hVPS29 leads to the depletion of the E3 SUMO ligase, PIAS1, and the accumulation of huCOP1. Under heat stress conditions, the levels of SUMO-conjugates are significantly lower in Arabidopsis vps29-3 mutants, indicating a regulatory role of AtVPS29 on AtSIZ1 activity. Moreover, AtVPS29 inhibits ubiquitination pathway-dependent degradation of AtSIZ1. Notably, AtSIZ1 forms a complex with AtVPS29 and trimeric retromer proteins. Taken together, our results indicate that VPS29 plays an essential role in signal transduction by regulating SIZ/PIAS-type E3 ligase-dependent sumoylation in both plants and animals. | Min, Wang Ki; Kwak, Jun Soo; Kwon, Dae Hwan; Kim, Sung-Il; Park, Sang Woo; Ahn, Jiyoung; Cho, Soobin; Kim, Myung-Jin; Lee, Seung Ju; Song, Jong Tae; Kim, Yonghwan; Seo, Hak Soo | Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Forestry & Bioresources, Seoul 08826, South Korea; Sookmyung Womens Univ, Res Inst Womens Hlth & Digital Humanity Ctr, Dept Biol Sci, Seoul 04310, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | 57797161600; 57188934445; 57216938492; 57206875788; 57221239272; 59760564000; 59760577300; 57218082177; 57797133900; 57797134000; 57204676401; 26642769200 | seohs@snu.ac.kr; | PLANT JOURNAL | PLANT J | 0960-7412 | 1365-313X | 122 | 2 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 0 | 2025-05-07 | 0 | 0 | SIZ1; VPS29; E3 SUMO ligase; PIAS1; COP1; retromer protein; SUMO; sumoylation; vacuolar protein sorting | SALICYLIC-ACID; ACQUIRED-RESISTANCE; ARABIDOPSIS; COMPLEX; TOLERANCE; HORMONE; GROWTH; UBIQUITINATION; MECHANISMS; EXPRESSION | COP1; E3 SUMO ligase; PIAS1; retromer protein; SIZ1; SUMO; sumoylation; vacuolar protein sorting; VPS29 | Accumulation; Cells; Displays; Plants; Sorting; Stresses; Transport; Type; Arabidopsis; Arabidopsis Proteins; Gene Expression Regulation, Plant; Humans; Ligases; Reactive Oxygen Species; Salicylic Acid; Signal Transduction; Sumoylation; Ubiquitin-Protein Ligases; Ubiquitination; Vesicular Transport Proteins; Cell signaling; Arabidopsis protein; ligase; reactive oxygen metabolite; salicylic acid; SIZ1 protein, Arabidopsis; ubiquitin protein ligase; vesicular transport protein; Constitutive photomorphogenic 1; E3 small ubiquitin-related modifier ligase; Ligases; PIAS1; Retromer protein; SIZ1; Small ubiquitin-related modifiers; Sumoylation; Vacuolar protein sorting; Vacuolar protein sorting 29; Arabidopsis; gene expression regulation; genetics; human; metabolism; signal transduction; sumoylation; ubiquitination; Yeast | English | 2025 | 2025-04 | 10.1111/tpj.70166 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | XERICO as a target for engineering stress-resilient crops: Mechanisms, applications, and future directions | XERICO's capacity to enhance ABA-driven stress responses across diverse crops, its regulatory crosstalk with other hormonal pathways, and its compatibility with advanced genetic engineering tools highlight its central role in sustainable agriculture. Leveraging XERICO in crop improvement programs aligns with the urgent need to mitigate the impacts of climate-induced stress in agriculture, offering a pathway toward resilient and high-yielding crops. By enabling crops to withstand drought and other environmental stresses, XERICO-based biotechnological approaches hold transformative potential for global food security and environmental sustainability. | Im, Jong Hee; Kim, Won-Chan; Han, Kyung-Hwan; Ko, Jae-Heung | Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA; Jeju Natl Univ, Interdisciplinary Grad Program Adv Convergence Tec, Jeju 63243, South Korea; Michigan State Univ, DOE Great Lakes Bioenergy Res Ctr, E Lansing, MI 48824 USA; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Michigan State Univ, Dept Forestry, E Lansing, MI 48824 USA; Kyung Hee Univ, Grad Sch Green Biosci, Yongin 17104, South Korea | Ko, Jae-Hyeon/I-4133-2019 | 59735181100; 55492085000; 7402963224; 7402678816 | hanky@msu.edu; jhko@khu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 225 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 0 | 2025-06-11 | 0 | 0 | ABA regulation; Climate resilience; Drought tolerance; Environmental stress; Genetic engineering; Sustainable agriculture; XERICO | TRANSCRIPTIONAL REGULATORY NETWORKS; ARABIDOPSIS SEED-GERMINATION; CONFERS DROUGHT TOLERANCE; ABSCISIC-ACID; RING FINGER; GENE; OVEREXPRESSION; PROTEINS | ABA regulation; Climate resilience; Drought tolerance; Environmental stress; Genetic engineering; Sustainable agriculture; XERICO | Abscisic Acid; Crops, Agricultural; Droughts; Genetic Engineering; Plant Proteins; Plants, Genetically Modified; Stress, Physiological; abscisic acid; plant protein; crop; drought; genetic engineering; genetics; metabolism; physiological stress; procedures; transgenic plant | English | 2025 | 2025-08 | 10.1016/j.plaphy.2025.110013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | EpicPred: predicting phenotypes driven by epitope-binding TCRs using attention-based multiple instance learning | Motivation: Correctly identifying epitope-binding T-cell receptors (TCRs) is important to both understand their underlying biological mechanism in association to some phenotype and accordingly develop T-cell mediated immunotherapy treatments. Although the importance of the CDR3 region in TCRs for epitope recognition is well recognized, methods for profiling their interactions in association to a certain disease or phenotype remains less studied. We developed EpicPred to identify phenotype-specific TCR–epitope interactions. EpicPred first predicts and removes unlikely TCR–epitope interactions to reduce false positives using the Open-set Recognition (OSR). Subsequently, multiple instance learning was used to identify TCR–epitope interactions specific to a cancer type or severity levels of COVID-19 infected patients. Results: From six public TCR databases, 244 552 TCR sequences and 105 unique epitopes were used to predict epitope-binding TCRs and to filter out non-epitope-binding TCRs using the OSR method. The predicted interactions were used to further predict the phenotype groups in two cancer and four COVID-19 TCR-seq datasets of both bulk and single-cell resolution. EpicPred outperformed the competing methods in predicting the phenotypes, achieving an average AUROC of 0.80 ± 0.07. Availability and implementation: The EpicPred Software is available at https://github.com/jaeminjj/EpicPred. © The Author(s) 2025. Published by Oxford University Press. | Jeon, Jaemin; Yu, Suwan; Lee, Sangam; Kim, Sang Cheol; Jo, Hye-Yeong; Jung, Inuk; Kim, Kwangsoo | Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 08826, South Korea; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 08826, South Korea; College of Computing, Yonsei University, Seoul, 03722, South Korea; Division of Healthcare and Artificial Intelligence, Korea National Institute of Health, Cheongju, 28159, South Korea; Division of Healthcare and Artificial Intelligence, Korea National Institute of Health, Cheongju, 28159, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, 03080, South Korea, Department of Medicine, Seoul National University, Seoul, 03080, South Korea | 58145888700; 59342807300; 59354766800; 55989489800; 57158666600; 56067575500; 57210575084 | inukjung@knu.ac.kr; kwangsookim@snu.ac.kr; | Bioinformatics | BIOINFORMATICS | 1367-4803 | 1367-4811 | 41 | 3 | SCIE | BIOCHEMICAL RESEARCH METHODS;MATHEMATICAL & COMPUTATIONAL BIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 5.4 | 8.7 | 0 | 2025-05-07 | 0 | Computational Biology; COVID-19; Epitopes, T-Lymphocyte; Humans; Machine Learning; Neoplasms; Phenotype; Receptors, Antigen, T-Cell; SARS-CoV-2; Software; epitope; lymphocyte antigen receptor; bioinformatics; coronavirus disease 2019; human; immunology; machine learning; metabolism; neoplasm; phenotype; procedures; Severe acute respiratory syndrome coronavirus 2; software; virology | English | Final | 2025 | 10.1093/bioinformatics/btaf080 | 바로가기 | 바로가기 | 바로가기 |
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