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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles ⓘ Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution. ⓘ Jang, Jiuk; Kim, Joohee; Shin, Haein; Park, Young-Geun; Joo, Byung Jun; Seo, Hunkyu; Won, Jong-eun; Kim, Dai Woo; Lee, Chang Young; Kim, Hong Kyun; Park, Jang-Ung ⓘ Yonsei Univ, Nano Sci Technol Inst, Dept Mat Sci & Engn, Seoul 03722, South Korea; Inst Basic Sci IBS, Ctr Nanomed, Seoul 03722, South Korea; Yonsei Univ, 3KIURI Inst, Seoul 03722, South Korea; Korea Univ, Dept Dent, Guro Hosp, Seoul 08308, South Korea; Korea Univ, Inst Clin Dent Res, Guro Hosp, Seoul 08308, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, 130 Dongdeok Ro, Daegu 41944, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Ulsan 44919, South Korea ⓘ ; Park, Young-Geun/GLV-4849-2022; Lee, Chang/E-3793-2010; Park, Jang-Ung/E-9224-2010; Kim, Hong Kyun/ITT-7758-2023 ⓘ 57211724305; 57208530366; 57222707966; 57197777700; 57222706899; 57217280976; 36550880100; 57095192800; 57190739878; 57218260940; 11739935500 ⓘ okeye@knu.ac.kr;jang-ung@yonsei.ac.kr; ⓘ SCIENCE ADVANCES ⓘ SCI ADV ⓘ 2375-2548 7 14 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 14.98 8.8 3.78 2025-07-30 ⓘ 109 88 ⓘ MEIBOMIAN GLAND-FUNCTION; DRY EYE SYMPTOMS; LARGE-AREA; ON-SKIN; SENSOR; ELECTRONICS ⓘ ⓘ Biocompatibility; Field effect transistors; Graphene transistors; mHealth; Pathology; Biomedical information; Graphene field-effect transistors; Hyperthermia treatments; Matrix metalloproteinase-9; Personal health managements; Physiological signals; Real time measurements; Wireless communications; Contact lenses ⓘ English 2021 2021-03 10.1126/sciadv.abf7194 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Strong constraints from COSINE-100 on the DAMA dark matter results using the same sodium iodide target ⓘ We present new constraints on dark matter interactions using 1.7 years of COSINE-100 data. The COSINE-100 experiment, consisting of 106 kg of tallium-doped sodium iodide [NaI(Tl)] target material, is aimed to test DAMA's claim of dark matter observation using the same NaI(Tl) detectors. Improved event selection requirements, a more precise understanding of the detector background, and the use of a larger dataset considerably enhance the COSINE-100 sensitivity for dark matter detection. No signal consistent with the dark matter interaction is identified and rules out model-dependent dark matter interpretations of the DAMA signals in the specific context of standard halo model with the same NaI(Tl) target for various interaction hypotheses. ⓘ Adhikari, Govinda; de Souza, Estella B.; Carlin, Nelson; Choi, Jae Jin; Choi, Seonho; Djamal, Mitra; Ezeribe, Anthony C.; Franca, Luis E.; Ha, Chang Hyon; Hahn, In Sik; Jeon, Eunju; Jo, Jay Hyun; Joo, Han Wool; Kang, Woon Gu; Kauer, Matthew; Kim, Hyounggyu; Kim, Hongjoo; Kim, Kyungwon; Kim, Sunghyun; Kim, Sun Kee; Kim, Won Kyung; Kim, Yeongduk; Kim, Yong-Hamb; Ko, Young Ju; Lee, Eun Kyung; Lee, Hyunseok; Lee, Hyun Su; Lee, Hye Young; Lee, In Soo; Lee, Jaison; Lee, Jooyoung; Lee, Moo Hyun; Lee, Seo Hyun; Lee, Seung Mok; Leonard, Douglas; Manzato, Bruno B.; Maruyama, Reina H.; Neal, Robert J.; Olsen, Stephen L.; Park, Byung Ju; Park, Hyang Kyu; Park, Hyeonseo; Park, Kangsoon; Pitta, Ricardo L. C.; Prihtiadi, Hafizh; Ra, Sejin; Rott, Carsten; Shin, Keon Ah; Scarff, Andrew; Spooner, Neil J. C.; Thompson, William G.; Yang, Liang; Yu, Gyun Ho ⓘ Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA; Yale Univ, Dept Phys, New Haven, CT 06520 USA; Yale Univ, Wright Lab, New Haven, CT 06520 USA; Univ Sao Paulo, Phys Inst, BR-05508090 Sao Paulo, Brazil; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; Bandung Inst Technol, Dept Phys, Bandung 40132, Indonesia; Univ Sheffield, Dept Phys & Astron, Sheffield S3 7RH, S Yorkshire, England; Chung Ang Univ, Dept Phys, Seoul 06973, South Korea; Ewha Womans Univ, Dept Sci Educ, Seoul 03760, South Korea; Inst Basic Sci IBS, Ctr Exot Nucl Studies, Daejeon 34126, South Korea; Univ Sci & Technol UST, IBS Sch, Daejeon 34113, South Korea; Inst Basic Sci IBS, Ctr Underground Phys, Daejeon 34126, South Korea; Univ Wisconsin, Dept Phys, Madison, WI 53706 USA; Univ Wisconsin, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Sejong Univ, Dept Phys, Seoul 05006, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea; Korea Univ, Dept Accelerator Sci, Sejong 30019, South Korea; Sungkyunkwan Univ, Dept Phys, Suwon 16419, South Korea ⓘ Ha, Chang Hyon/AAR-8120-2021; Lee, Seung Mok/JXM-0966-2024; Maruyama, Reina/A-1064-2013; Kauer, Matt/AAY-7581-2020; Schneider Hahn, Ivanete/H-9015-2016; Ko, Young/AEI-0838-2022; DJAMAL, MITRA/JFJ-1152-2023; Thompson, William/H-2407-2011; Lee, Moo/AAK-4266-2020; Lee, Hye-Young/JEP-8044-2023; França, Luis Eduardo/AET-2735-2022; Kim, Dae-Hyun/AAA-4463-2020; KIM, Sun Kee/IQT-8178-2023; Laranjeira Couto Pitta, Ricardo/K-4152-2018; Lee, Jooyoung/HTN-0335-2023; Kim, Hong Joo/AAE-1178-2022; Funo de Moura Franca, Luis Eduardo/AET-2735-2022 ⓘ 56811058500; 57200584326; 7006320391; 58263015500; 57199723894; 6506355194; 56300952200; 57219686017; 17342119700; 57192312712; 57204519171; 55575536700; 56375205700; 24401181300; 55196156000; 59615156600; 59051568100; 57209988432; 7601588326; 59102407800; 55492072500; 7410207253; 57196171764; 56030036300; 57226673940; 23477682800; 56113238600; 57199646872; 55816685400; 57226402706; 57204797944; 57198252980; 57257129200; 55902330700; 7201953933; 57211139944; 9334469000; 57211139925; 35227722100; 57204904910; 8455192000; 57216599536; 35225979300; 57208178150; 57188983477; 16480794500; 35227850400; 57203522213; 56300978900; 7005922145; 57200581630; 57192656960; 57208174900 ⓘ yjko@ibs.re.kr;hyunsulee@ibs.re.kr; ⓘ SCIENCE ADVANCES ⓘ SCI ADV ⓘ 2375-2548 7 46 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 14.98 8.8 1.78 2025-07-30 ⓘ 43 35 ⓘ WIMP SEARCH; MODULATION ⓘ ⓘ Galaxies; Iodine compounds; Sodium Iodide; Dark matter; Dark matter detection; Event selection; Large datasets; Target materials; Dark Matter ⓘ English 2021 2021-11 10.1126/sciadv.abk2699 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The mechanism of gap creation by a multifunctional nuclease during base excision repair ⓘ During base excision repair, a transient single-stranded DNA (ssDNA) gap is produced at the apurinic/apyrimidinic (AP) site. Exonuclease III, capable of performing both AP endonuclease and exonuclease activity, are responsible for gap creation in bacteria. We used single-molecule fluorescence resonance energy transfer to examine the mechanism of gap creation. We found an AP site anchor-based mechanism by which the intrinsically distributive enzyme binds strongly to the AP site and becomes a processive enzyme, rapidly creating a gap and an associated transient ssDNA loop. The gap size is determined by the rigidity of the ssDNA loop and the duplex stability of the DNA and is limited to a few nucleotides to maintain genomic stability. When the 3' end is released from the AP endonuclease, polymerase I quickly initiates DNA synthesis and fills the gap. Our work provides previously unidentified insights into how a signal of DNA damage changes the enzymatic functions. ⓘ Yoo, Jungmin; Lee, Donghun; Im, Hyeryeon; Ji, Sangmi; Oh, Sanghoon; Shin, Minsang; Park, Daeho; Lee, Gwangrog ⓘ Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea; Gwangju Inst Sci & Technol, Single Mol Biol Lab, Gwangju 61005, South Korea; Gwangju Inst Sci & Technol, Cell Mechanobiol Lab, Gwangju 61005, South Korea; Gwangju Inst Sci & Technol, Dept Biomed Sci & Engn, Gwangju 61005, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea ⓘ ⓘ 43961756800; 57226076579; 57193553685; 57226094274; 57193554251; 7401536650; 8942151500; 7404852965 ⓘ glee@gist.ac.kr; ⓘ SCIENCE ADVANCES ⓘ SCI ADV ⓘ 2375-2548 7 29 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 14.98 8.8 0.7 2025-07-30 ⓘ 17 16 ⓘ COLI ENDONUCLEASE-IV; SINGLE-STRANDED-DNA; ESCHERICHIA-COLI; EXONUCLEASE-III; DEOXYRIBONUCLEIC-ACID; LAMBDA-EXONUCLEASE; POLYMERASE; COORDINATION; DEGRADATION; LANDSCAPE ⓘ ⓘ DNA; DNA Damage; DNA Repair; DNA Replication; DNA, Single-Stranded; DNA-(Apurinic or Apyrimidinic Site) Lyase; Energy transfer; Enzymes; Fluorescence; DNA; DNA (apurinic or apyrimidinic site) lyase; single stranded DNA; Base excision repairs; Duplex stability; Enzymatic functions; Exonuclease activity; Exonuclease iii; Genomic stability; Single molecule fluorescence; Single-stranded DNA; DNA damage; DNA repair; DNA replication; genetics; metabolism; DNA ⓘ English 2021 2021-07 10.1126/sciadv.abg0076 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea ⓘ BACKGROUND: Because severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) rarely occur, clinical data based on large-scale studies are still lacking. OBJECTIVE: To provide information on culprit drugs and clinical characteristics, including morbidity and mortality of SCARs based on a nationwide registry. METHODS: SCAR cases that occurred from 2010 to 2015 were recruited to the Korean SCAR registry from 34 tertiary referral hospitals. Demographics, causative drugs, causality, and clinical outcomes were collected by reviewing the medical record. RESULTS: A total of 745 SCAR cases (384 SJS/TEN cases and 361 DRESS cases) due to 149 drugs were registered. The main causative drugs were allopurinol (14.0%), carbamazepine (9.5%), vancomycin (4.7%), and antituberculous agents (6.3%). A strong preference for SJS/TEN was observed in carbonic anhydrase inhibitors (100%), nonsteroidal anti-inflammatory drugs (84%), and acetaminophen (83%), whereas dapsone (100%), antituberculous agents (81%), and glycopeptide antibacterials (78%) were more likely to cause DRESS. The mortality rate was 6.6% (SJS/TEN 8.9% and DRESS 4.2%). The median time to death was 19 days and 29 days in SJS/TEN and DRESS respectively, and 89.8% of deaths occurred within 60 days after the onset of the skin symptoms. CONCLUSION: Allopurinol, carbamazepine, vancomycin, and antituberculous agents were the leading causes of SCARs in Korea. Some drugs preferentially caused a specific phenotype. The mortality rate of SCARs was 6.6%, and most of the deaths occurred within 2 months. (C) 2020 American Academy of Allergy, Asthma & Immunology ⓘ Kang, Dong Yoon; Yun, James; Lee, Suh-Young; Koh, Young-Il; Sim, Da Woon; Kim, Sujeong; Nam, Young Hee; Park, Jung-Won; Kim, Sae Hoon; Ye, Young-Min; Park, Hye-Kyung; Kim, Min-Hye; Jee, Young-Koo; Jung, Jae-Woo; Yang, Min-Suk; Kim, Sang-Heon; Lee, Jun Kyu; Kim, Cheol-Woo; Hur, Gyu Young; Kim, Mi-Yeong; Park, Seoung Ju; Kwon, Yong Eun; Choi, Jeong-Hee; Kim, Joo-Hee; Kim, Sang Hyon; La, Hyen O.; Kang, Min-Gyu; Park, Chan Sun; Lee, Sang Min; Jeong, Yi Yeong; Kim, Hee-Kyoo; Jin, Hyun Jung; Jeong, Jae-Won; Lee, Jaechun; Lee, Yong Won; Lee, Seung Eun; Kim, Myoung Shin; Kang, Hye-Ryun ⓘ Seoul Natl Univ Hosp, Drug Safety Monitoring Ctr, Seoul, South Korea; Nepean Hosp, Dept Immunol & Rheumatol, Sydney, NSW, Australia; Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Ajou Univ, Dept Internal Med, Sch Med, Suwon, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Dankook Univ, Dept Internal Med, Coll Med, Cheonan, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Dongguk Univ, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Inha Univ, Dept Internal Med, Sch Med, Incheon, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea; Chonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; Chosun Univ Hosp, Dept Internal Med, Gwangju, South Korea; Hallym Univ, Dept Internal Med, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Pharmacol, Seoul, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Inje Univ, Dept Internal Med, Haeundae Paik Hosp, Busan, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju, South Korea; Kosin Univ, Dept Internal Med, Coll Med, Busan, South Korea; Yeungnam Univ, Dept Internal Med, Med Sch, Daegu, South Korea; Inje Univ, Dept Internal Med, Ilsan Paik Hosp, Goyang, South Korea; Jeju Natl Univ Hosp, Dept Internal Med, Jeju, South Korea; Catholic Kwandong Univ, Dept Internal Med, Coll Med, Incheon, South Korea; Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Dermatol, Coll Med, Seoul, South Korea ⓘ Lee, Yong Won/AAN-4587-2021; Jin, Hyunjung/MHR-8031-2025; Kim, Ju-Hyoung/N-1450-2019; Park, Seoungju/D-4444-2014; Lee, Seung Eun/ABG-1607-2021; Lee, Jae-Hyun/ABE-3803-2020; Park, Hye-Kyung/Q-5586-2019; Lee, JongGu/B-7384-2013; Lee, Jae-Uk/AAB-5674-2020; Kim, Dae/AAJ-7518-2021; Kim, Yon/J-2743-2012; Kim, Sae/AAR-3907-2020; Kim, Joo/JAZ-0897-2023 ⓘ 37077171700; 55347730600; 54684477700; 58914386100; 57188552688; 36666447400; 37006947800; 8591768500; 35198322400; 13405438300; 57208252986; 58045929900; 7005104108; 57189648165; 7404927140; 56590456700; 57201264381; 7409872246; 7004193730; 55892381000; 8578599900; 56281121100; 7501395695; 57191685789; 36470282200; 35985652100; 55908899100; 57191996109; 55913470000; 7202332057; 55910350900; 36157127500; 55449687300; 23991023300; 27170844400; 57202327298; 23985278000; 7404070922 ⓘ helenmed@snu.ac.kr; ⓘ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE ⓘ J ALLER CL IMM-PRACT ⓘ 2213-2198 2213-2201 9 2 SCIE ALLERGY;IMMUNOLOGY ⓘ 2021 11.022 8.9 1.52 2025-07-30 ⓘ 23 25 Drug-related side effects and adverse reactions; Stevens-Johnson syndrome; Drug hypersensitivity syndrome; Registries; Republic of Korea ⓘ STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; LONG-TERM SEQUELAE; SYSTEMIC SYMPTOMS; DRESS SYNDROME; DRUG REACTION; EOSINOPHILIA; MORTALITY; SCIENCE; MARKER ⓘ Drug hypersensitivity syndrome; Drug-related side effects and adverse reactions; Registries; Republic of Korea; Stevens-Johnson syndrome ⓘ Allopurinol; Carbamazepine; Humans; Registries; Republic of Korea; Stevens-Johnson Syndrome; aceclofenac; allopurinol; amoxicillin; carbamazepine; carbonate dehydratase inhibitor; cefaclor; cefotaxime; ceftriaxone; celecoxib; ciprofloxacin; cotrimoxazole; dapsone; dexibuprofen; ethambutol; gabapentin; ibuprofen; isoniazid; lamotrigine; levetiracetam; levofloxacin; loxoprofen; mefenamic acid; meropenem; methazolamide; nafcillin; oxcarbazepine; paracetamol; phenytoin; piperacillin plus tazobactam; polypeptide antibiotic agent; pyrazinamide; quinolone derivative; rifampicin; salazosulfapyridine; teicoplanin; valproic acid; vancomycin; carbamazepine; adult; adverse event; aged; Article; clinical feature; clinical outcome; disease duration; disease exacerbation; DRESS syndrome; emergency ward; female; groups by age; hospitalization; human; intensive care unit; Korea; major clinical study; male; morbidity; mortality rate; onset age; outpatient; phenotype; prognosis; sever cutaneous adverse reaction; severe cutaneous adverse reaction; skin disease; Stevens Johnson syndrome; toxic epidermal necrolysis; clinical trial; multicenter study; register; South Korea; Stevens Johnson syndrome ⓘ English 2021 2021-02 10.1016/j.jaip.2020.09.011 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Randomized, Noninferiority Trial Comparing ICS thorn LABA with ICS plus LABA plus LAMA in Asthma-COPD Overlap (ACO) Treatment: The ACO Treatment with Optimal Medications (ATOMIC) Study ⓘ BACKGROUND: Current guidelines for the treatment of asthma and chronic obstructive pulmonary disease overlap (ACO) recommend initial treatment using inhaled corticosteroids (ICSs) plus 1 or more bronchodilators. OBJECTIVE: To clarify which therapeutic effect is better between the ICS D long-acting beta(2) agonist (LABA) and ICS D LABA D long-acting muscarinic antagonist (LAMA) treatment in patients with ACO. METHODS: We conducted a multicenter, 48-week, randomized, noninferiority trial. Patients with ACO were enrolled if they were treated with a moderate to high dose of ICS D LABA. In total, 303 patients were involved in the present trial, with 149 receiving ICS D LABA D LAMA. The primary end point was the time to first exacerbation. Secondary outcomes included changes in FEV1, forced vital capacity, FEV1/forced vital capacity ratio, asthma control, blood eosinophil count, and fractional exhaled nitric oxide. RESULTS: In the ICS D LABA treatment group, 29 of 154 patients (18.83%) experienced exacerbation, whereas 28 of 149 patients (18.79%) experienced exacerbation in the ICS D LABA D LAMA treatment group. The results of this noninferiority study were ultimately inconclusive (hazard ratio, 1.1; 95% CI, 0.66-1.84). However, the patients treated with the addition of LAMA showed significant improvements in FEV1 and forced vital capacity (P <.001). Asthma control did not improve in either group. CONCLUSIONS: Although this study was unable to conclude that ICS D LABA treatment is not inferior to ICS D LABA D LAMA in terms of exacerbation, it is obvious that the ICS D LABADLAMA treatment group had improved lung function in ACO. (C) 2020 American Academy of Allergy, Asthma & Immunology ⓘ Park, So-Young; Kim, Solmi; Kim, Jung-Hyun; Kim, Sae-Hoon; Lee, Taehoon; Yoon, Sun-Young; Kim, Min-Hye; Moon, Ji-Yong; Yang, Min-Suk; Jung, Jae-Woo; Kim, Joo-Hee; Choi, Jeong-Hee; Park, Chan Sun; Kim, Sujeong; Lee, Jaechun; Kwon, Jae-Woo; Hur, Gyu Young; Kim, Sang-Ha; Kim, Hee-Kyoo; Shin, Yoo Seob; Kim, Sang-Hoon; Nam, Young-Hee; Jang, An-Soo; Park, Seo Young; Kim, Tae-Bum ⓘ Univ Ulsan, Asan Med Ctr, Dept Allergy & Clin Immunol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Konkuk Univ, Dept Internal Med, Sch Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; Armed Forces Capital Hosp, Dept Internal Med, Div Allergy & Clin Immunol, Seongnam, South Korea; Seoul Natl Univ, Dept Internal Med, Div Allergy & Clin Immunol, Bundang Hosp, Seongnam, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Coll Med, Ulsan, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Internal Med, Sch Med, Daejeon, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Metropolitan Govt Seoul Natl Univ Boramae M, Dept Internal Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Hallym Univ, Dept Pulmonol & Allergy, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Hallym Univ, Allergy & Clin Immunol Res Ctr, Coll Med, Chunchon, South Korea; Inje Univ, Dept Internal Med, Haeundae Paik Hosp, Busan, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; Kangwon Natl Univ, Dept Allergy & Clin Immunol, Sch Med, Chunchon, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Kosin Univ, Dept Internal Med, Coll Med, Busan, South Korea; Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; Eulji Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Dept Internal Med, Dong A Univ, Coll Med, Busan, South Korea; Soonchunhyang Univ, Sch Med, Dept Internal Med, Bucheon Hosp, Bucheon, South Korea; Univ Ulsan, Asan Med Ctr, Dept Clin Epidemiol & Biostat, Coll Med, Seoul, South Korea ⓘ Lee, Taehoon/AHA-1437-2022; Kim, Jin-Seok/AAK-5424-2020; Kim, Sang-Ha/ACC-9085-2022; Lee, JongGu/B-7384-2013; Kim, Ju-Hyoung/N-1450-2019; Kim, Hye/AAF-7609-2020; Kim, Jung-Hyun/D-2980-2011; Kim, Sae/AAR-3907-2020; Lee, Jae-Hyun/ABE-3803-2020; MOON, Ji-yong/U-1476-2018; JANG, AN-SOO/A-4686-2011; MOON, Ji-Yong/U-1476-2018 ⓘ 57077220500; 57219871054; 58119342400; 35198322400; 57205134034; 56452038900; 58045929900; 58760742600; 7404927140; 57189648165; 57191685789; 7501395695; 57191996109; 36666447400; 23991023300; 57204538197; 7004193730; 55718908700; 55910350900; 55552132100; 57196226893; 37006947800; 7004582727; 57210022574; 57206927697; 37062104600; 35285863400; 7404469543; 56473736700; 57219975542; 57200008729; 35314596800; 55472202600; 57213917744; 36157127500; 57208252986; 59285301500; 55492809000; 55888715900 ⓘ tbkim@amc.seoul.kr; ⓘ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE ⓘ J ALLER CL IMM-PRACT ⓘ 2213-2198 2213-2201 9 3 SCIE ALLERGY;IMMUNOLOGY ⓘ 2021 11.022 8.9 1.39 2025-07-30 ⓘ 19 22 Asthma-COPD overlap; ICS; LABA; LAMA; Triple therapy ⓘ ⓘ Asthma-COPD overlap; ICS; LABA; LAMA; Triple therapy ⓘ Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Asthma; Bronchodilator Agents; Drug Therapy, Combination; Humans; Muscarinic Antagonists; Pulmonary Disease, Chronic Obstructive; beclometasone dipropionate plus formoterol fumarate; budesonide plus formoterol; fluticasone furoate plus vilanterol; fluticasone propionate plus formoterol fumarate; fluticasone propionate plus salmeterol xinafoate; tiotropium bromide; beta 2 adrenergic receptor stimulating agent; bronchodilating agent; corticosteroid; muscarinic receptor blocking agent; adult; Article; asthma-chronic obstructive pulmonary disease overlap syndrome; bladder dysfunction; clinical practice; cohort analysis; controlled study; disease control; disease exacerbation; drug efficacy; eosinophil count; female; forced expiratory volume; forced vital capacity; fractional exhaled nitric oxide; human; human cell; lung function; major clinical study; male; middle aged; multicenter study; patient care; randomized controlled trial; treatment duration; treatment outcome; asthma; chronic obstructive lung disease; clinical trial; combination drug therapy; inhalational drug administration ⓘ English 2021 2021-03 10.1016/j.jaip.2020.09.066 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion ⓘ Acute kidney injury (AKI) induces distant organ injury, which is a serious concern in patients with AKI. Recent studies have demonstrated that distant organ injury is associated with oxidative stress of organ and damage of cilium, an axoneme-based cellular organelle. However, the role of oxidative stress and cilia damage in AKIinduced lung injury remains to be defined. Here, we investigated whether AKI-induced lung injury is associated with mitochondrial oxidative stress and cilia disruption in lung cells. AKI was induced in isocitrate dehydrogenase 2 (Idh2, a mitochondrial antioxidant enzyme)-deleted (Idh2- /- ) and wild-type (Idh2+/+) mice by kidney ischemia-reperfusion (IR). A group of mice were treated with Mito-TEMPO, a mitochondria-specific antioxidant. Kidney IR caused lung injuries, including alveolar septal thickening, alveolar damage, and neutrophil accumulation in the lung, and increased protein concentration and total cell number in bronchoalveolar lavage fluid (BALF). In addition, kidney IR caused fragmentation of lung epithelial cell cilia and the release of fragments into BALF. Kidney IR also increased the production of superoxide, lipid peroxidation, and mitochondrial and nuclei DNA oxidation in lungs and decreased IDH2 expression. Lung oxidative stress and injury relied on the degree of kidney injury. Idh2 deletion exacerbated kidney IR-induced lung injuries. Treatment with Mito-TEMPO attenuated kidney IR-induced lung injuries, with greater attenuation in Idh2-/- than Idh2+/+ mice. Our data demonstrate that AKI induces the disruption of cilia and damages cells via oxidative stress in lung epithelial cells, which leads to the release of disrupted ciliary fragments into BALF. ⓘ Han, Yong Kwon; Kim, Ji Su; Lee, Gwan Beom; Lim, Jae Hang; Park, Kwon Moo ⓘ Kyungpook Natl Univ, Sch Med, Cardiovasc Res Inst, Dept Anat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Ihwa Womans Univ, Sch Med, Dept Microbiol, 25 Magokdong Ro 2 Gil, Seoul 07804, South Korea ⓘ ⓘ 57226292650; 57226288568; 57226268502; 7403454262; 8785448200 ⓘ kmpark@knu.ac.kr; ⓘ REDOX BIOLOGY ⓘ REDOX BIOL ⓘ 2213-2317 46 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY ⓘ 2021 10.787 8.9 1.69 2025-07-30 ⓘ 20 21 Acute kidney injury; Cilia; Deciliation; Isocitrate dehydrogenase 2; Oxidative stress; Remote organ injury; Acute lung injury ⓘ ISCHEMIA/REPERFUSION INJURY; EPITHELIAL-CELLS; MITOCHONDRIAL; DEFICIENCY; ACTIVATION; SUSCEPTIBILITY; INCREASES; APOPTOSIS; LENGTH; DAMAGE ⓘ Acute kidney injury; Acute lung injury; Cilia; Deciliation; Isocitrate dehydrogenase 2; Oxidative stress; Remote organ injury ⓘ Acute Kidney Injury; Acute Lung Injury; Animals; Apoptosis; Cilia; Humans; Isocitrate Dehydrogenase; Lung; Mice; Oxidative Stress; Reperfusion Injury; Therapeutic Irrigation; isocitrate dehydrogenase 2; phosphonium derivative; superoxide; unclassified drug; [2 (2,2,6,6 tetramethylpiperidin 1 oxyl 4 ylamino) 2 oxoethyl]triphenylphosphonium chloride; isocitrate dehydrogenase; isocitrate dehydrogenase 2, mouse; acute kidney failure; animal cell; animal experiment; animal model; animal tissue; Article; bioaccumulation; bronchoalveolar lavage fluid; cell count; cell disruption; cilium; controlled study; disease association; disease exacerbation; enzyme synthesis; gene deletion; gene expression; Idh2 gene; lipid peroxidation; lung alveolus epithelium cell; lung injury; male; mitochondrion; mouse; neutrophil; nonhuman; oxidation; oxidative stress; renal ischemia reperfusion injury; acute lung injury; animal; apoptosis; cilium; genetics; human; lavage; lung; metabolism; oxidative stress; reperfusion injury ⓘ English 2021 2021-10 10.1016/j.redox.2021.102077 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Reintroduction of Antituberculous Drugs in Patients with Antituberculous Drug-Related Drug Reaction with Eosinophilia and Systemic Symptoms ⓘ BACKGROUND: Patients who suffered drug reaction with eosinophilia and systemic symptom (DRESS) during the treatment of tuberculosis (TB) commonly experience multidrug hypersensitivity reactions resulting in limited anti-TB drug choices. Therefore, reintroduction based on a desensitization protocol may be an option to resume anti-TB medication. OBJECTIVE: To evaluate the outcomes and safety of resuming anti-TB drugs according to reintroduction methods in patients with anti-TB drug-related DRESS. METHODS: A retrospective cohort of patients who had experienced anti-TB drug-related severe cutaneous adverse reactions from 2011 to 2017 was established from separate 5 institutions. RESULTS: Anti-TB medication was resumed in 27 of 29 patients with anti-TB drug-related DRESS through complete changing regimen (n = 9), reintroduction by a graded challenge (n = 5), or reintroduction using a desensitization protocol (n = 13). Nine patients completely changed their anti-TB regimen to second-line TB drugs, but only 1 (11.1%) succeeded in maintaining new anti-TB drugs. The other 8 failed to take drugs due to the occurrence of hypersensitivity reactions to the newly introduced anti-TB drugs. Two (40.0%) of 5 patients who underwent graded rechallenges successfully completed anti-TB drugs, whereas 3 (60%) failed to resume anti-TB drugs due to the recurrence of hypersensitivity reactions. In 13 patients who resumed anti-TB drugs using a desensitization protocol, no one who underwent desensitization developed recurrence of DRESS; 11 (84.6%) eventually completed anti-TB treatment and 2 eventually failed to complete anti-TB treatment due to late-onset itching and drug-induced liver injury. CONCLUSIONS: Resuming anti-TB medication based on desensitization protocols may be a safe and effective option for those with anti-TB drug-related DRESS. (C) 2021 American Academy of Allergy, Asthma & Immunology ⓘ Oh, Ji Hyun; Yun, James; Yang, Min-Suk; Kim, Jung-Hyun; Kim, Sae-Hoon; Kim, Sujeong; Choi, Jeong-Hee; Yim, Jae-Joon; Kang, Hye-Ryun ⓘ Seoul Natl Univ, Inst Allergy & Clin Immunol, Med Res Ctr, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Resp Allergy Med, Coll Med, Cheonan, South Korea; Nepean Hosp, Dept Immunol & Rheumatol, Sydney, NSW, Australia; Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia; Seoul Natl Univ, Dept Internal Med, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Hallym Univ, Dept Pulmonol & Allergy, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Seoul Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Drug Safety Monitoring Ctr, Seoul, South Korea ⓘ ; Kim, Sae/AAR-3907-2020; Yim, Jae/J-2783-2012; Kim, Ju-Hyoung/N-1450-2019 ⓘ 57043893700; 55347730600; 7404927140; 58119342400; 35198322400; 36666447400; 7501395695; 7101736410; 7404070922 ⓘ helenmed@snu.ac.kr; ⓘ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE ⓘ J ALLER CL IMM-PRACT ⓘ 2213-2198 2213-2201 9 9 SCIE ALLERGY;IMMUNOLOGY ⓘ 2021 11.022 8.9 0.99 2025-07-30 ⓘ 16 16 Antitubercular agents; Drug hypersensitivity; Drug hypersensitivity syndrome; Immunologic desensitization ⓘ RAPID ORAL DESENSITIZATION; STEVENS-JOHNSON-SYNDROME; HYPERSENSITIVITY REACTIONS; DRESS SYNDROME; PATCH; MANAGEMENT; ERUPTION; RISK ⓘ Antitubercular agents; Drug hypersensitivity; Drug hypersensitivity syndrome; Immunologic desensitization ⓘ amikacin; aminosalicylic acid; amoxicillin plus clavulanic acid; antihistaminic agent; corticosteroid; cycloserine; ethambutol; isoniazid; kanamycin; levofloxacin; moxifloxacin; protionamide; pyrazinamide; rifampicin; streptomycin; tuberculostatic agent; adult; aged; allergic reaction; Article; clinical article; desensitization; DRESS syndrome; drug rechallenge; drug safety; drug substitution; drug withdrawal; drug-induced liver injury; extrapulmonary tuberculosis; female; human; hypertransaminasemia; lung tuberculosis; maculopapular rash; male; middle aged; miliary tuberculosis; patch test; pruritus; rash; retrospective study; skin disease; skin manifestation; Stevens Johnson syndrome; tuberculosis; very elderly; young adult ⓘ English 2021 2021-09 10.1016/j.jaip.2021.03.054 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice ⓘ CD44v6, a splice variant of the cell surface glycoprotein CD44, acts as a co-receptor for c-Met and is upregulated in tumors with high metastatic potential. Methods: We screened a phage-displayed peptide library for peptides that selectively bind to CD44v6-overexpressing cells and exploited them to block CD44v6 and deliver a pro-apoptotic peptide to tumors for cancer therapy. Results: CNLNTIDTC (NLN) and CNEWQLKSC (NEW) peptides bound preferentially to CD44v6-high cells than to CD44v6-low cells. The binding affinities of NLN and NEW to CD44v6 protein were 253 79 and 85 +/- 18 nM, respectively. Peptide binding to CD44v6-high cells was inhibited by the knockdown of CD44v6 gene expression and competition with an anti-CD44v6 antibody. A pull-down assay with biotin-labeled peptides enriched CD44v6 from cell lysates. NLN and NEW induced CD44v6 internalization and inhibited hepatocyte growth factor-induced c-Met internalization, c-Met and Erk phosphorylation, and cell migration and invasion. In mice harboring tumors, intravenously administered NLN and NEW homed to the tumors and inhibited metastasis to the lungs. When combined with crizotinib, a c-Met inhibitor, treatment with each peptide inhibited metastatic growth more efficiently than each peptide or crizotinib alone. In addition, KLAKLAKKLAKLAK pro-apoptotic peptide guided by NLN (NLN-KLA) or NEW (NEW-KLA) killed tumor cells and inhibited tumor growth and metastasis. No significant systemic side effects were observed after treatments. Conclusions: These results suggest that NLN and NEW are promising metastasis-inhibiting peptide therapeutics and targeting moieties for CD44v6-expressing metastases. ⓘ Khan, Fatima; Gurung, Smriti; Gunassekaran, Gowri Rangaswamy; Vadevoo, Sri Murugan Poongkavithai; Chi, Lianhua; Permpoon, Uttapol; Haque, Md. Enamul; Lee, Yun-Ki; Lee, Soo-Woong; Kim, Soyoun; Lee, Byungheon ⓘ Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, 680 Gukchaebosang Ro, Daegu 41944, South Korea ⓘ ; Chi, Lianhua/JAC-5202-2023; Khan, Fatima/GQP-2552-2022 ⓘ 57205752395; 57205752137; 36028043400; 56663280000; 55348368300; 57205752273; 57654780700; 57211232298; 57221228306; 58847992000; 16304374900 ⓘ leebh@knu.ac.kr; ⓘ THERANOSTICS ⓘ THERANOSTICS ⓘ 1838-7640 11 3 SCIE MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2021 11.6 9.0 2.08 2025-07-30 ⓘ 23 22 CD44v6; c-Met; metastasis; peptide; phage display ⓘ BIVATUZUMAB MERTANSINE; ISOFORM EXPRESSION; CANCER; MET; CARCINOMA; TARGET; HEAD; NECK ⓘ C-Met; CD44v6; Metastasis; Peptide; Phage display ⓘ Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Crizotinib; Female; HEK293 Cells; Hepatocyte Growth Factor; Humans; Hyaluronan Receptors; MAP Kinase Signaling System; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Peptides; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Up-Regulation; antineoplastic agent; asparagylglutamicylacidtryptophan; asparagylglutamicylacidtryptophanlysylleucylalanine; asparagylleucylasparagine; biotin; CD44v6 antibody; CD44v6 antigen; cell surface protein; crizotinib; peptide; scatter factor receptor; unclassified drug; CD44v6 antigen; crizotinib; hyaluronic acid binding protein; peptide; protein kinase inhibitor; scatter factor; scatter factor receptor; add on therapy; animal cell; animal experiment; animal model; Article; binding affinity; breast cancer; cancer chemotherapy; cancer inhibition; cell lysate; cell migration; controlled study; drug delivery system; drug megadose; female; gene knockdown; human; human cell; in vitro study; in vivo study; low drug dose; lung metastasis; metastatic breast cancer; mouse; nonhuman; protein analysis; protein binding; protein phosphorylation; RNA splice site; tumor cell; animal; apoptosis; Bagg albino mouse; cell line; cell motion; cell proliferation; drug effect; HEK293 cell line; MAPK signaling; MCF-7 cell line; metabolism; metastasis; nude mouse; tumor cell line; upregulation ⓘ English 2021 2021 10.7150/thno.50564 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS ⓘ The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane, or both, thereby decreasing the efficacy of RAI therapy. Genetic aberrations (such as BRAF, RAS, and RET/PTC rearrangements) have been reported to be prominently responsible for the onset, progression, and dedifferentiation of DTCs, mainly through the activation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Eventually, these alterations result in a lack of NIS and disabling of RAI uptake, leading to the development of resistance to RAI therapy. Over the past decade, promising approaches with various targets have been reported to restore NIS expression and RAI uptake in preclinical studies. In this review, we summarized comprehensive molecular mechanisms underlying the dedifferentiation in RAI-refractory DTCs and reviews strategies for restoring RAI avidity by tackling the mechanisms. ⓘ Oh, Ji Min; Ahn, Byeong-Cheol ⓘ Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Gukchaebosang Ro 680, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea ⓘ ⓘ 57190370462; 7202791511 ⓘ abc2000@knu.ac.kr; ⓘ THERANOSTICS ⓘ THERANOSTICS ⓘ 1838-7640 11 13 SCIE MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2021 11.6 9.0 3.96 2025-07-30 ⓘ 98 96 radioactive iodine refractory thyroid cancer; redifferentiation; signaling pathways; sodium iodide symporter; membrane targeting ⓘ TERT PROMOTER MUTATIONS; GROWTH-FACTOR-BETA; HISTONE DEACETYLASE INHIBITOR; TUMOR-TRANSFORMING GENE; NF-KAPPA-B; ENHANCED RADIOIODINE UPTAKE; RETINOIC ACID TREATMENT; RECEPTOR-GAMMA AGONIST; BRAF V600E MUTATION; PHASE-II TRIAL ⓘ Membrane targeting; Radioactive iodine refractory thyroid cancer; Redifferentiation; Signaling pathways; Sodium iodide symporter ⓘ Autophagy; Cell Differentiation; Cell Membrane; Clinical Trials as Topic; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Iodine Radioisotopes; MicroRNAs; Neoplasm Proteins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Receptors, Thyrotropin; Recombinant Proteins; Salvage Therapy; Signal Transduction; Symporters; Thyroid Neoplasms; Thyrotropin; estrogen related receptor alpha; liver X receptor; microRNA; peroxisome proliferator activated receptor gamma; platelet derived growth factor alpha receptor; radioactive iodine; retinoic acid receptor; sodium iodide symporter; cell receptor; cotransporter; microRNA; radioactive iodine; recombinant protein; sodium iodide symporter; thyrotropin; thyrotropin receptor; tumor protein; autophagy (cellular); canonical Wnt signaling; cellular distribution; DNA methylation; epigenetics; histone modification; hormone metabolism; human; MAPK signaling; molecular mechanics; NF kB signaling; nonhuman; Notch signaling; Pi3K/Akt signaling; protein expression; protein localization; Review; Smad signaling; TGF beta signaling; thyroid cancer; autophagy; cell differentiation; cell membrane; clinical trial (topic); drug effect; drug resistance; gene expression regulation; gene therapy; genetic epigenesis; genetics; metabolism; pathology; protein transport; salvage therapy; signal transduction; thyroid tumor ⓘ English 2021 2021 10.7150/thno.57689 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles ⓘ Aims: Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. Neutrophils produce different subtypes of EVs during inflammatory responses. Neutrophil-derived trails (NDTRs) are generated by neutrophils migrating toward inflammatory foci, whereas neutrophil-derived microvesicles (NDMVs) are thought to be generated by neutrophils that have arrived at the inflammatory foci. However, the physical and functional characteristics of neutrophil-derived EVs are incompletely understood. In this study, we aimed to investigate the differences between NDTRs and NDMVs. Methods: The generation of neutrophil-derived EVs were visualized by live-cell fluorescence images and the physical characteristics were further analyzed using nanotracking analysis assay, scanning electron microscopic analysis, and marker expressions. Functional characteristics of neutrophil-derived EVs were analyzed using assays for bactericidal activity, monocyte chemotaxis, phenotype polarization of macrophages, and miRNA sequencing. Finally, the effects of neutrophil-derived EVs on the acute and chronic inflammation were examined in vivo. Results: Both EVs share similar characteristics including stimulators, surface marker expression, bactericidal activity, and chemoattractive effect on monocytes via MCP-1. However, the integrin-mediated physical interaction was required for generation of NDTRs whereas NDMV generation was dependent on PI3K pathway. Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. Although both EVs were easily uptaken by monocytes, NDTRs enhanced proinflammatory macrophage polarization whereas NDMVs induced anti-inflammatory macrophage polarization. Moreover, NDTRs showed protective effects against lethality in a murine sepsis model and pathological changes in a murine chronic colitis model. Conclusion: These results suggest that NDTR is a proinflammatory subtype of neutrophil-derived EVs distinguished from NDMV. ⓘ Youn, Young-Jin; Shrestha, Sanjeeb; Lee, Yu-Bin; Kim, Jun-Kyu; Lee, Jee Hyun; Hur, Keun; Mali, Nanda Maya; Nam, Sung-Wook; Kim, Sun-Hwa; Lee, Sunwoong; Song, Dong-Keun; Jin, Hee Kyung; Bae, Jae-sung; Hong, Chang-Won ⓘ Kyungpook Natl Univ, Sch Med, Dept Physiol, 680 Gukchaeborang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 24252, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Stem Cell Neuroplastic Res Grp, Daegu 41944, South Korea ⓘ Youn, Young Jin/KQU-0973-2024; Hur, Keun/G-9513-2011; Kim, Young/T-8521-2019; Bae, Jae-sung/AAM-8663-2021; Nam, Sung-Wook/V-5519-2019 ⓘ 57195676656; 57059866700; 57219808197; 57192897853; 57216817247; 8861888000; 57195987350; 16167127700; 57219815385; 57215897149; 7402443736; 8088145800; 35209510400; 55567018400 ⓘ cwhong@knu.ac.kr; ⓘ THERANOSTICS ⓘ THERANOSTICS ⓘ 1838-7640 11 6 SCIE MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2021 11.6 9.0 6 2025-07-30 ⓘ 62 61 EV; extracellular vesicle; NDMV; neutrophil-derived microvesicle; NDTR; neutrophil-derived trail ⓘ MICROPARTICLES; MICRORNAS; ECTOSOMES; EXPRESSION; ACTIVATION; MONOCYTES; DIFFERENTIATION; HETEROGENEITY; MICROVESICLES; MACROPHAGES ⓘ EV; Extracellular vesicle; NDMV; Neutrophil-derived microvesicle; NDTR; Neutrophil-derived trail ⓘ Animals; Biomarkers; Cell Communication; Cells, Cultured; Chemotaxis; Colitis; Disease Models, Animal; Extracellular Vesicles; Humans; Inflammation; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Monocytes; Neutrophils; Sepsis; THP-1 Cells; CD163 antigen; CD86 antigen; complement component C5a; formylmethionylleucylphenylalanine; gamma interferon; high mobility group B1 protein; inducible nitric oxide synthase; integrin; interleukin 12; interleukin 1beta; interleukin 4; interleukin 6; lipopolysaccharide; major histocompatibility antigen class 2; microRNA; microRNA 126; microRNA 1260; microRNA 1285; microRNA 150; microRNA 4454; microRNA 451a; microRNA 7975; monocyte chemotactic protein 1; n(g) nitroarginine methyl ester; pathogen associated molecular pattern; phorbol 13 acetate 12 myristate; phosphatidylinositol 3 kinase; protein S100B; superoxide dismutase; transforming growth factor beta; tumor necrosis factor; unclassified drug; biological marker; microRNA; animal cell; animal experiment; animal model; animal tissue; Article; bactericidal activity; cell assay; chemotaxis; chronic inflammation; colitis; controlled study; disease model; Escherichia coli; exosome; fluorescence analysis; human; human cell; in vivo study; inflammation; lethality; live cell imaging; macrophage; male; monocyte; mouse; mouse model; neutrophil; neutrophil derived extracellular vesicle; neutrophil derived trail; nonhuman; phenotype; polarization; protein expression; protein interaction; protein transport; RNA sequencing; scanning electron microscopy; sepsis; Staphylococcus aureus; animal; Bagg albino mouse; cell communication; cell culture; exosome; inflammation; macrophage activation; metabolism; neutrophil; physiology; THP-1 cell line ⓘ English 2021 2021 10.7150/thno.51756 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Artificial intelligence (AI) applications in adsorption of heavy metals using modified biochar ⓘ The process of removal of heavy metals is important due to their toxic effects on living organisms and undesirable anthropogenic effects. Conventional methods possess many irreconcilable disadvantages pertaining to cost and efficiency. As a result, the usage of biochar, which is produced as a by-product of biomass pyrolysis, has gained sizable traction in recent times for the removal of heavy metals. This review elucidates some widely recognized harmful heavy metals and their removal using biochar. It also highlights and compares the variety of feedstock available for preparation of biochar, pyrolysis variables involved and efficiency of biochar. Various adsorption ki-netics and isotherms are also discussed along with the process of desorption to recycle biochar for reuse as adsor-bent. Furthermore, this review elucidates the advancements in remediation of heavy metals using biochar by emphasizing the importance and advantages in the usage of machine learning (ML) and artificial intelligence (AI) for the optimization of adsorption variables and biochar feedstock properties. The usage of AI and ML is cost and time-effective and allows an interdisciplinary approach to remove heavy metals by biochar. (c) 2021 Published by Elsevier B.V. ⓘ Lakshmi, Divya; Akhil, Dilipkumar; Kartik, Ashokkumar; Gopinath, Kannappan Panchamoorthy; Arun, Jayaseelan; Bhatnagar, Amit; Rinklebe, Joerg; Kim, Woong; Muthusamy, Govarthanan ⓘ Sri Sivasubramaniya Nadar Coll Engn, Dept Chem Engn, Chennai 603110, Tamil Nadu, India; Sathyabama Inst Sci & Technol, Int Res Ctr, Ctr Waste Management, Chennai 600119, Tamil Nadu, India; LUT Univ, LUT Sch Engn Sci, Dept Separat Sci, Sammonkatu 12, FI-50130 Mikkeli, Finland; Univ Wuppertal, Inst Fdn Engn Water & Waste Management, Sch Architecture & Civil Engn, Lab Soil & Groundwater Management, Pauluskirchstr 7, D-42285 Wuppertal, Germany; Sejong Univ, Dept Environm Energy & Geoinformat, 98 Gunja Dong, Seoul, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea ⓘ ; Govarthanan, Muthusamy/C-1491-2014; Muthusamy, Govarthanan/C-1491-2014; BHATNAGAR, AMIT/A-8838-2008; Jayaseelan, Arun/AAT-5552-2021; Bhatnagar, Amit/A-8838-2008; Rinklebe, Joerg/Y-2398-2019 ⓘ 57221229788; 57221232199; 57221220970; 24757925200; 57195403181; 7202474586; 55893080100; 55581636400; 54881927600 ⓘ elshine@knu.ac.kr;gova.muthu@gmail.com; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 801 SCIE ENVIRONMENTAL SCIENCES ⓘ 2021 10.754 9.1 1.39 2025-07-30 ⓘ 105 107 Adsorption; Biochar; Heavy metals; Rare metals; Machine learning ⓘ EFFICIENT REMOVAL; AQUEOUS-SOLUTION; NEURAL-NETWORK; WASTE-WATER; PYROLYSIS TEMPERATURE; MERCURY REMOVAL; CO-PYROLYSIS; BY-PRODUCT; RICE STRAW; FIXED-BED ⓘ Adsorption; Biochar; Heavy metals; Machine learning; Rare metals ⓘ Adsorption; Artificial Intelligence; Charcoal; Metals, Heavy; Adsorption; Biology; Efficiency; Feedstocks; Machine learning; Pyrolysis; arsenic; cadmium; carbon; cellulose; cerium; charcoal; chromium; copper; heavy metal; hemicellulose; hydrogen; lanthanum; lead; lignin; mercury; metal organic framework; nickel; rhenium; scandium; selenium; surfactant; thorium; uranium; zinc; biochar; charcoal; Adsorption kinetics and isotherm; Anthropogenic effects; Bio chars; Biomass pyrolysis; Conventional methods; Living organisms; Machine-learning; Rare metals; Reuse; Toxic effect; adsorption; artificial intelligence; biochar; efficiency measurement; experimental study; heavy metal; laboratory method; rare earth element; adsorption isotherm; adsorption kinetics; apricot; artificial intelligence; artificial neural network; ball milling; biomass; chemical procedures; coating (procedure); convolutional neural network; cost effectiveness analysis; date (fruit); decision tree; desorption; ecosystem restoration; Egeria; Egeria najas; electrochemical analysis; elemental analysis; Eucalyptus; Ficus; Ficus microcarpa; gasification; generative adversarial network; heavy metal removal; human; human impact (environment); image processing; isotherm; k nearest neighbor; machine learning; magnetization; metal impregnation; microwave radiation; multilayer perceptron; particle size; pH; pineapple; porosimetry; pyrolysis; radial basis function neural network; random forest; recurrent neural network; Review; sawdust; Sesbania; Sesbania bispinosa; support vector machine; surface area; surfactant modification; technology; ultrasonication; walnut; adsorption; Heavy metals ⓘ English 2021 2021-12-20 10.1016/j.scitotenv.2021.149623 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Assessment of environmental and economic aspects of household food waste using a new Environmental-Economic Footprint (EN-EC) index: A case study of Daegu, South Korea ⓘ While the global food demand has continued to increase, the enormous natural resources required for its production are limited, in addition to the accompanying environmental degradation. Despite all these, food waste generation continues unabated, especially at the household level, further compounding the environmental impacts, economic cost, and food security issues. In this study, granular primary data of edible household foodwaste using direct-weighing from218 households in Daegu, South Koreawas used to assess the environmental (carbon footprint, andwater footprint) and economic (wasted cost) impacts associated with theirwastage. For the first time, the Environmental-Economic (EN-EC) Footprint index is proposed as a single indicator for environmental and economic impacts to assess the hotspot food waste products among the selected 42 major food waste items. This study presents that the selected food products had a significant contribution to an average edible food waste generation of 0.73 +/- 0.06 kg (per household/day), 0.71 +/- 0.05 kg CO(2)eq of GHG emissions, 0.46 +/- 0.04 m(3) of water footprint, and 3855.93 +/- 527.27 won of economic loss, respectively. Based on the newly developed EN-EC Footprint index, we found thatwasted animal-based food products had relatively high environmental and economic losses compared to non-animal-based food products. The findings of this study presented a novel method of estimating combined environmental and economic impacts associated with household food waste, which may further act as convenient guides for the waste management authorities and policymakers in addressing the mitigation of household food waste impacts. (c) 2021 Elsevier B.V. All rights reserved. ⓘ Adelodun, Bashir; Kim, Sang Hyun; Odey, Golden; Choi, Kyung-Sook ⓘ Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240103, Nigeria; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea ⓘ Odey, Golden/MVV-6310-2025; Adelodun, Bashir/O-2941-2018 ⓘ 57193774482; 57211805802; 57211444984; 54392662900 ⓘ adelodun.b@unilorin.edu.ng;ks.choi@knu.ac.kr; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 776 SCIE ENVIRONMENTAL SCIENCES ⓘ 2021 10.754 9.1 1.62 2025-07-30 ⓘ 38 39 Environmental impacts; Economic loss; EN-EC Footprint index; Food waste; Daegu South Korea ⓘ GREENHOUSE-GAS EMISSIONS; PER-CAPITA VALUE; WATER; CONSUMPTION; GENERATION; BEHAVIOR; COUNTRY; LOSSES; SYSTEM; CARBON ⓘ Daegu South Korea; Economic loss; EN-EC Footprint index; Environmental impacts; Food waste ⓘ South Korea; Taegu [South Korea]; Taegu [Taegu (ADS)]; Indicator indicator; Animals; Cost benefit analysis; Economic analysis; Economic and social effects; Greenhouse gases; Losses; Waste management; water; Daegu south korea; Economic loss; Environmental and economic impacts; Environmental economics; Environmental-economic footprint footprint index; Food waste; Household food; South Korea; Waste generation; Water footprint; domestic waste; ecological footprint; economic impact; environmental economics; environmental impact assessment; food waste; waste management; Article; carbon footprint; controlled study; domestic waste; economic aspect; economic loss; environmental aspects and related phenomena; Environmental Economic Footprint index; environmental impact; environmental parameters; food waste; South Korea; waste management; water and water related phenomena; water footprint; Carbon footprint ⓘ English 2021 2021-07-01 10.1016/j.scitotenv.2021.145928 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Biochar from the co-pyrolysis of Saccharina japonica and goethite as an adsorbent for basic blue 41 removal from aqueous solution ⓘ The effects of utilizing goethite (5%, 10%, and 20%) in co-pyrolysis with low-lignin macroalgae, Saccharina japon-ica, on the carbon sequestration potential, magnetic, physicochemical, and dye (basic blue 41, BB41) removal properties of the resulting biochar were investigated. Biochars exhibited more aromaticity, better magnetic prop-erties, and insignificant alterations to their point of zero charges (11.07 +/- 0.03 to 10.59 +/- 0.01) with goethite increment. Optimum conditions for high organic matter conversion and carbon preservation occurred using 5% goethite. Adsorption experiments showed that BB41 adsorption was highly pH-dependent, equilibrated later (from 12 h to 24 h) after goethite modification, and was best fitted to the pseudo-second-order model (higher R-2 and lower SSE values). Langmuir monolayer adsorption capacity for BB41 was the highest amongst carbona-ceous adsorbents in the literature [1494 mg/g (pristine); 1216 mg/g (5% goethite)]; initial BB41 concentration of 2000 mg/L at 30 degrees C and pH 8. The main governing mechanisms involved ion exchanges, hydrogen bonding, pi-pi interaction and pore-filling. Overall, low goethite amount (5%), co-pyrolyzed with macroalgae, offers an econom-ically and environmentally effective way to produce magnetic biochar with enhanced carbon sequestration po-tential and superb cationic dye removal performance for environmental remediation applications. (C) 2021 Elsevier B.V. All rights reserved. ⓘ Sewu, Divine Damertey; Woo, Seung Han; Lee, Dae Sung ⓘ Life Green Technol Co Ltd, 875 Yuseong Daero, Daejeon 34158, South Korea; Hanbat Natl Univ, Dept Chem & Biol Engn, 125 Dongseo Daero, Daejeon 34158, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Sewu, Divine/AAA-6886-2021 ⓘ 57192414005; 7402853418; 55568524907 ⓘ shwoo@hanbat.ac.kr; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 797 SCIE ENVIRONMENTAL SCIENCES ⓘ 2021 10.754 9.1 1.11 2025-07-30 ⓘ 26 27 Adsorption; Biochar; Co-pyrolysis; Carbon conversion; Goethite; Macroalgae ⓘ CATIONIC DYE; EFFICIENT ADSORPTION; MAGNETIC BIOCHAR; WASTE-WATER; CARBON; KINETICS; MACROALGAE; BIOMASS; EQUILIBRIUM; PROPERTY ⓘ Adsorption; Biochar; Carbon conversion; Co-pyrolysis; Goethite; Macroalgae ⓘ Adsorption; Dyes; Hydrogen Bonds; Ion Exchange; Magnetic Properties; Monolayers; Adsorption; Charcoal; Iron Compounds; Kinetics; Laminaria; Minerals; Pyrolysis; Water Pollutants, Chemical; Laminaria japonica; Adsorption; Carbonaceous adsorbents; Dyes; Hydrogen bonds; Ion exchange; Magnetism; Monolayers; Physicochemical properties; Pyrolysis; activated carbon; biochar; ferric hydroxide; organic matter; unclassified drug; biochar; charcoal; ferric hydroxide; iron derivative; mineral; Basic blue 41; Bio chars; Carbon conversions; Carbon sequestration potential; Copyrolysis; Goethite; Macro-algae; Physico-chemicals; Property; Saccharina japonicas; adsorption; aqueous solution; biochar; bioremediation; carbon sequestration; dye; goethite; macroalga; pyrolysis; aqueous solution; Article; biomass; carbon sequestration; centrifugation; chemical analysis; chemical interaction; dehydrogenation; ecosystem restoration; Fourier transform infrared spectroscopy; hydrogen bond; inductively coupled plasma atomic emission spectrometry; infrared spectroscopy; magnetic field; medical literature; nonhuman; physical chemistry; pyrolysis; room temperature; Saccharina japonica; surface property; adsorption; kinetics; Laminaria; pyrolysis; water pollutant; Carbon ⓘ English 2021 2021-11-25 10.1016/j.scitotenv.2021.149160 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ecofriendly, selective removal of radioactive strontium ions in aqueous solutions using magnetic banana peels ⓘ Radionuclide Sr2+ in aqueous solution was removed using a large amount of banana peel (BP). Magnetized BP, mag@BP, was synthesized for recovery after the adsorption process. The synthesis was a very simple process of precipitation of BP with a magnetic substance. The synthesized adsorbent was thoroughly examined by performing Fourier-transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction analysis, and vibration sample magnetometer analysis. Moreover, mag@BP has a Sr2+ maximum adsorption capacity of 23.827 mg/g according to isothermal adsorption, which is the best fit for the Langmuir isotherm model. In the pH effect experiment, the highest Sr2+ adsorption capacity was found at pH 9, and it has a spontaneous adsorption mechanism through experiments on temperature, time, and selectivity, and it reaches adsorption equilibrium within a short time and has high selectivity through competitive adsorption with Na+. In addition, an adsorption mechanism accompanied by ion exchange with K+ on the surface of BP, bonding with various functional groups, and electrical attraction were established. Therefore, mag@BP is suitable for use an environmentally friendly, low cost, and recoverable adsorbent for magnetic removal of Sr2+ from aqueous solutions. Further, unlike other carbon-based adsorbents, it does not cause cytotoxicity. (C) 2021 Elsevier B.V. All rights reserved. ⓘ Choi, Jung-Weon; Cho, Sangeun; Choi, Sang-June ⓘ Korea Res Inst Chem Technol KRICT, Green Carbon Catalysis Ctr, 141 Gajeong Ro, Daejeon 34114, South Korea; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ⓘ 56996378900; 57222313825; 56605563600 ⓘ jwchoi92@krict.re.kr;sjchoi@knu.ac.kr; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 778 SCIE ENVIRONMENTAL SCIENCES ⓘ 2021 10.754 9.1 0.74 2025-07-30 ⓘ 18 22 Adsorption; Banana peel; Ecofriendly; Green chemistry; Radionuclides; Strontium ⓘ METHYLENE-BLUE; ADSORPTIVE REMOVAL; FUNCTIONAL-GROUPS; CESIUM; BIOCHAR; WASTE; COMPOSITE; SORPTION; BIOSORPTION; ADSORBENTS ⓘ Adsorption; Banana peel; Ecofriendly; Green chemistry; Radionuclides; Strontium ⓘ Adsorption; Hydrogen-Ion Concentration; Ions; Kinetics; Magnetic Phenomena; Musa; Solutions; Spectroscopy, Fourier Transform Infrared; Strontium; Water Pollutants, Chemical; Adsorption isotherms; Chemical bonds; Environmental protection; Fourier transform infrared spectroscopy; Fruits; Ion exchange; Kinetics; Magnetism; pH effects; Radioisotopes; Scanning electron microscopy; Strontium; Strontium compounds; Vibration analysis; X ray powder diffraction; carbon; strontium; ion; strontium; Adsorption capacities; Adsorption mechanism; Banana peels; Eco-friendly; Green-chemistry; Large amounts; Radioactive strontium; Selective removal; Strontium ion; Synthesised; adsorption; aqueous solution; chemistry; ion; pollutant removal; radionuclide; strontium; adsorption; aqueous solution; Article; banana peel; chemical binding; controlled study; cytotoxicity; Fourier transform infrared spectroscopy; fruit peel; ion exchange; pH; radioactivity; scanning electron microscopy; synthesis; temperature; time; vibrating sample magnetometry; X ray diffraction; infrared spectroscopy; kinetics; magnetism; Musa; solution and solubility; water pollutant; Adsorption ⓘ English 2021 2021-07-15 10.1016/j.scitotenv.2021.146327 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Endoscopic Resection Is Superior to Gastrectomy for Gastric Cancer Regarding the Risk of Incident Type 2 Diabetes: A Nationwide Cohort Study ⓘ ⓘ Ha, Jane; Kwon, Yeongkeun; Kim, Dohyang; Hwang, Jinseub; Kwon, Jin-Won; Park, Sungsoo ⓘ Korea Univ, Coll Med, Seoul, Seoul Tukpyolsi, South Korea; Daegu Univ, Gyongsan, Kyongsang Bukto, South Korea; Kyungpook Natl Univ, Daegu, Taegu Jikhalsi, South Korea ⓘ Park, Sun-Young/B-4634-2014 ⓘ ⓘ ⓘ AMERICAN JOURNAL OF GASTROENTEROLOGY ⓘ AM J GASTROENTEROL ⓘ 0002-9270 1572-0241 116 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2021 12.045 9.1 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-10 ⓘ 바로가기 바로가기
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