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○ ○ Editorial Material ⓘ Healthy bone tissue homeostasis ⓘ ⓘ Choi, Je-Yong ⓘ Kyungpook Natl Univ, Korea Mouse Phenotyping Consortium, Bone Dis Anal Ctr, Dept Biochem & Cell Biol,Sch Med, Daegu 41644, South Korea ⓘ Choi, Je-Yong/AAR-7334-2021 ⓘ 7501391068 ⓘ jechoi@knu.ac.kr; ⓘ EXPERIMENTAL AND MOLECULAR MEDICINE ⓘ EXP MOL MED ⓘ 1226-3613 2092-6413 52 8 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2020 8.718 9.6 0.71 2025-06-25 ⓘ 15 13 ⓘ ⓘ ⓘ Animals; Bone and Bones; Cytokines; Homeostasis; Humans; selenium; transcription factor RUNX2; cytokine; bone tissue; Editorial; embryo development; genetic disorder; hematopoiesis; homeostasis; human; human tissue; osteoarthritis; osteoporosis; protein function; animal; bone; metabolism; physiology ⓘ English 2020 2020-08 10.1038/s12276-020-0472-3 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue ⓘ Obesity: Possible protective enzyme identified An enzyme that limits the build-up of reactive oxygen species (ROS) in fat cells protects mice against metabolic stress during a high-fat diet. Calorie overload leads to high levels of damaging ROS in the mitochondria of brown fat cells. This can disrupt processes that regulate energy expenditure and glucose metabolism. A team led by Seung-Soon Im at Keimyung University, Daegu, South Korea, and Timothy F. Osborne at Johns Hopkins University, St. Petersburg, USA, examined the role of an enzyme called isocitrate dehydrogenase 2 (IDH2), which is known to regulate the build-up of mitochondrial ROS. In mice fed a high-fat diet, those without IDH2 experienced accelerated weight gain, triggered by increased ROS levels and decreased mitochondrial function. A dose of an antioxidant in the diet reduced this effect, suggesting that patients with obesity may benefit from antioxidant supplements. Isocitrate dehydrogenase 2 (IDH2) is an NADP(+)-dependent enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate in the mitochondrial matrix, and is critical for the production of NADPH to limit the accumulation of mitochondrial reactive oxygen species (ROS). Here, we showed that high-fat diet (HFD) feeding resulted in accelerated weight gain in the IDH2KO mice due to a reduction in whole-body energy expenditure. Moreover, the levels of NADP(+), NADPH, NAD(+), and NADH were significantly decreased in the brown adipose tissue (BAT) of the HFD-fed IDH2KO animals, accompanied by decreased mitochondrial function and reduced expression of key genes involved in mitochondrial biogenesis, energy expenditure, and ROS resolution. Interestingly, these changes were partially reversed when the antioxidant butylated hydroxyanisole was added to the HFD. These observations reveal a crucial role for IDH2 in limiting ROS-dependent mitochondrial damage when BAT metabolism is normally enhanced to limit weight gain in response to dietary caloric overload. ⓘ Lee, Jae-Ho; Go, Younghoon; Kim, Do-Young; Lee, Sun Hee; Kim, Ok-Hee; Jeon, Yong Hyun; Kwon, Taeg Kyu; Bae, Jae-Hoon; Song, Dae-Kyu; Rhyu, Im Joo; Lee, In-Kyu; Shong, Minho; Oh, Byung-Chul; Petucci, Christopher; Park, Jeen-Woo; Osborne, Timothy F.; Im, Seung-Soon ⓘ Keimyung Univ, Dept Physiol, Sch Med, Daegu 42601, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Korea Inst Oriental Med, Korean Med Applicat Ctr, Daegu 41062, South Korea; Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Dept Physiol, Sch Med, Incheon 21999, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Keimyung Univ, Dept Immunol, Sch Med, Daegu 42601, South Korea; Korea Univ, Dept Anat, Coll Med, Seoul 02841, South Korea; Chungnam Natl Univ Hosp, Res Ctr Endocrinol & Metab, 282 Munhwaro, Daejeon 35015, South Korea; Sanford Burnham Prebys Med Discovery Inst, Ctr Metab Origins Dis, Orlando, FL 32827 USA; Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA; Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Johns Hopkins Univ, Inst Fundamental Biomed Res, Dept Med & Biol Chem, Sch Med, St Petersburg, FL 33701 USA ⓘ Jeon, Yong/N-6910-2019; shong, minho/H-7803-2012; Lee, Jae-Ho/I-1935-2019; Osborne, Timothy/IAR-7119-2023; park, jun yeon/GPX-5293-2022; Lee, In-Kyu/AAR-6374-2021 ⓘ 55224798300; 55455882000; 57214690250; 57214694209; 36463666400; 16042453400; 7202206057; 7201386763; 7402443802; 55666938800; 36071537600; 7003976276; 7202848469; 55897475500; 35574514000; 7102366864; 57211749547 ⓘ tosborn9@jhmi.edu;ssim73@kmu.ac.kr; ⓘ EXPERIMENTAL AND MOLECULAR MEDICINE ⓘ EXP MOL MED ⓘ 1226-3613 2092-6413 52 2 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2020 8.718 9.6 2.02 2025-06-25 ⓘ 38 38 ⓘ ENERGY-EXPENDITURE; DYSFUNCTION; OBESITY; IDH2; DIFFERENTIATION; MACROPHAGES; MUTATIONS; SUCCINATE; COMPLEX; NADPH ⓘ ⓘ Adipose Tissue, Brown; Animals; Antioxidants; Diet, High-Fat; Isocitrate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mitochondria; NADP; Organelle Biogenesis; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Stress, Physiological; butylated hydroxyanisole; isocitrate dehydrogenase 2; nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide phosphate; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate; antioxidant; isocitrate dehydrogenase; isocitrate dehydrogenase 2, mouse; nicotinamide adenine dinucleotide phosphate; reactive oxygen metabolite; animal cell; animal experiment; animal tissue; Article; body weight gain; brown adipose tissue; caloric intake; comparative study; controlled study; diet-induced obesity; dietary pattern; disorders of mitochondrial functions; energy expenditure; homeostasis; male; metabolic stress; mitochondrial biogenesis; mitochondrion; mouse; nonhuman; oxidative stress; adverse event; animal; brown adipose tissue; C57BL mouse; lipid diet; metabolism; mitochondrion; organelle biogenesis; oxidation reduction reaction; physiological stress; physiology ⓘ English 2020 2020-02 10.1038/s12276-020-0379-z ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Molecular detection of Enterocytozoon hepatopenaei and Vibrio parahaemolyticus-associated acute hepatopancreatic necrosis disease in Southeast Asian Penaeus vannamei shrimp imported into Korea ⓘ Sixty batches of white leg shrimp (Penaeus vannamei, 40-50 shrimp per batch) imported from multiple countries, including Vietnam, Indonesia, Malaysia, and Peru were collected from fishery markets in South Korea. Five shrimp were randomly selected from each batch, the hepatopancreases of shrimp were collected, and samples from each batch were pooled and analyzed via PCR. Examination by qPCR indicated that the shrimp were infected by two emerging pathogens, Enterocytozoon hepatopenaei (EHP) and Vibrio parahaemolyticus carrying pirA and pirB toxins, which are associated with acute hepatopancreatic necrosis disease (Vp(AHPND)). Specifically, EHP was detected in the shrimp imported from Vietnam and Indonesia (17/60 samples, 28%) and Vp(AHPND) was detected in the shrimp imported from Vietnam (1/60, 2%). One sample highly infected with EHP (C-t = 20.86 +/- 1.47, corresponding to the copy number of 8.5 x 10(5)-5.2 x 10(6)) was also infected with Vp(AHPND) (C-t = 29.36 +/- 0.25, corresponding to the copy number of 2.5 x 10(3)-3.4 x 10(3)). These results indicate that EHP and Vp(AHPND), which are not currently listed as quarantine-required shrimp pathogens in Korea, can be introduced to Korea through shrimp importing activities and may pose a potential threat to Korean shrimp culture industry. Greater awareness regarding importing of diseased shrimps, and subsequent enforcement of quarantine policies relating to these pathogens are required to ensure that South Korea remains EHP- and Vp(AHPND)-free. ⓘ Han, Jee Eun; Lee, Seung Chan; Park, Seul Chan; Jeon, Hye Jin; Kim, Kyeong Yeon; Lee, Young Seo; Park, Song; Han, Se-Hyeon; Kim, Ji Hyung; Choi, Seong-Kyoon ⓘ Kyungpook Natl Univ, Coll Vet Med, Lab Aquat Biomed, Daegu 41566, South Korea; DGIST, Core Prot Resources Ctr, Daegu 42988, South Korea; Dept News Team, SBS, Mokdongseo Ro 161, Seoul, South Korea; Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon 34141, South Korea; DGIST, Div Biotechnol, Daegu 42988, South Korea ⓘ Kim, Ji Hyung/B-7321-2011 ⓘ 57214671240; 57212199348; 57212190350; 57212193058; 57212195103; 57212200636; 57139047900; 57210915063; 57225000204; 55505432500 ⓘ kzh81@kribb.re.kr;cskbest@dgist.ac.kr; ⓘ AQUACULTURE ⓘ AQUACULTURE ⓘ 0044-8486 1873-5622 517 SCIE FISHERIES;MARINE & FRESHWATER BIOLOGY ⓘ 2020 4.242 9.6 1.8 2025-06-25 ⓘ 19 21 EHP; Imported shrimp; Quarantine; South Korea; VpAHPND ⓘ EHP; EMERGENCE; PLASMID; AGENT; AHPND; PCR ⓘ EHP; Imported shrimp; Quarantine; South Korea; Vp<sub>AHPND</sub> ⓘ Indonesia; Malaysia; Peru; South Korea; Viet Nam; Decapoda (Crustacea); Enterocytozoon; Litopenaeus vannamei; Vibrio parahaemolyticus; bacterial disease; disease incidence; fishery management; market conditions; molecular analysis; quarantine; shrimp culture ⓘ English 2020 2020-02-25 10.1016/j.aquaculture.2019.734812 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases ⓘ In recent decades, the role of the peroxisome in physiology and disease conditions has become increasingly important. Together with the mitochondria and other cellular organelles, peroxisomes support key metabolic platforms for the oxidation of various fatty acids and regulate redox conditions. In addition, peroxisomes contribute to the biosynthesis of essential lipid molecules, such as bile acid, cholesterol, docosahexaenoic acid, and plasmalogen. Therefore, the quality control mechanisms that regulate peroxisome biogenesis and degradation are important for cellular homeostasis. Current evidence indicates that peroxisomal function is often reduced or dysregulated in various human disease conditions, such as neurodegenerative diseases. Here, we review the recent progress that has been made toward understanding the quality control systems that regulate peroxisomes and their pathological implications. ⓘ Jo, Doo Sin; Park, Na Yeon; Cho, Dong-Hyung ⓘ Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea ⓘ ; Choi, Hye Rin/JDV-9065-2023 ⓘ 56335489800; 57190609826; 35093684400 ⓘ dhcho@knu.ac.kr; ⓘ EXPERIMENTAL AND MOLECULAR MEDICINE ⓘ EXP MOL MED ⓘ 1226-3613 2092-6413 52 9 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2020 8.718 9.6 1.17 2025-06-25 ⓘ 80 72 ⓘ ALZHEIMERS-DISEASE; DOCOSAHEXAENOIC ACID; AUTOPHAGIC DEGRADATION; PARKINSONS-DISEASE; TARGETING SIGNAL; OXIDATIVE STRESS; AMYLOID-BETA; CHOLESTEROL-METABOLISM; MAMMALIAN PEROXISOMES; MOLECULAR-MECHANISM ⓘ ⓘ Animals; Biomarkers; Disease Susceptibility; Endoplasmic Reticulum; Homeostasis; Humans; Lipid Metabolism; Metabolic Networks and Pathways; Neurodegenerative Diseases; Oxidation-Reduction; Peroxisomes; Protein Processing, Post-Translational; ABC transporter subfamily D; ATM protein; catalase; cell protein; copper zinc superoxide dismutase; epoxide hydrolase; glutathione peroxidase; peroxin; peroxin 19; peroxiredoxin 5; peroxisomal targeting signal 1 receptor; peroxisomal targeting signal 2 receptor; peroxisome biogenesis factor 2; protein DNM1L; protein FIS1; protein MFF; protein PEX1; protein PEX10; protein PEX11; protein PEX11beta; protein PEX11gamma; protein PEX12; protein PEX13; protein PEX14; protein PEX16; protein PEX26; protein PEX3; protein PEX6; protein PMP70; unclassified drug; unindexed drug; biological marker; Alzheimer disease; autophagy (cellular); biogenesis; cell count; cell function; degenerative disease; disorders of lipid metabolism; human; lipid homeostasis; lipid metabolism; nonhuman; oxidation reduction state; Parkinson disease; pathogenesis; peroxisome; pexophagy; phenotype; quality control; Review; Zellweger syndrome; animal; degenerative disease; disease predisposition; endoplasmic reticulum; homeostasis; lipid metabolism; metabolism; oxidation reduction reaction; peroxisome; protein processing ⓘ English 2020 2020-09 10.1038/s12276-020-00503-9 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase ⓘ Aging, which is associated with age-related changes in physiological processes, is the most significant risk factor for the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Accumulating evidence has indicated that sphingolipids are significant regulators that are associated with pathogenesis in aging and several age-related neurodegenerative diseases. In particular, abnormal levels of acid sphingomyelinase (ASM), one of the significant sphingolipid-metabolizing enzymes, have been found in the blood and some tissues under various neuropathological conditions. Moreover, recent studies have reported the importance of ASM as a critical mediator that contributes to pathologies in aging and age-related neurodegenerative diseases. In this review, we describe the pathophysiological processes that are regulated by ASM, focusing on the age-related neurodegenerative environment. Furthermore, we discuss novel insights into how new therapeutics targeting ASM may potentially lead to effective strategies to combat aging and age-related neurodegenerative diseases. Age-related neurodegenerative diseases: role of enzyme crucial to membrane function Targeting a critical enzyme involved in the metabolism of cellular membrane molecules could help treat age-related neurodegenerative diseases. Aging is a key risk factor for the development of neurodegenerative diseases, including Alzheimer's and Parkinson's. Changes to the metabolism of sphingolipids, a group of bioactive cell membrane molecules, are recognised as a potential trigger of neurodegeneration. Abnormal expression levels of an enzyme called acid sphingomyelinase (ASM), which is involved in sphingolipid metabolism, have been found in patients with age-related diseases. Jae-sung Bae and co-workers at Kyungpook National University in Daegu, South Korea, reviewed research into ASM's role in these conditions. ASM levels increase with stress, bacterial infections and age. Studies on mice suggest high levels of ASM in plasma may disrupt the blood-brain barrier. The team highlight the therapeutic potential of ASM inhibition. ⓘ Park, Min Hee; Jin, Hee Kyung; Bae, Jae-sung ⓘ Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea ⓘ Bae, Jae-sung/AAM-8663-2021; Kim, Young/T-8521-2019 ⓘ 55807755700; 8088145800; 35209510400 ⓘ jsbae@knu.ac.kr; ⓘ EXPERIMENTAL AND MOLECULAR MEDICINE ⓘ EXP MOL MED ⓘ 1226-3613 2092-6413 52 3 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2020 8.718 9.6 0.92 2025-06-25 ⓘ 49 47 ⓘ BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; SPHINGOLIPID METABOLISM; FUNCTIONAL INHIBITORS; ALZHEIMERS-DISEASE; AMYLOID-BETA; CERAMIDE; CAVEOLAE; CHOLESTEROL; DYSFUNCTION ⓘ ⓘ Aging; Animals; Humans; Neurodegenerative Diseases; Sphingomyelin Phosphodiesterase; ad 2765; amitriptyline; arc 39; clomipramine; desipramine; doxepin; ent 12; imipramine; lofepramine; nortriptyline; protriptyline; sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase inhibitor; tamoxifen; trifluoperazine; unclassified drug; sphingomyelin phosphodiesterase; aging; Alzheimer disease; amyotrophic lateral sclerosis; brain ischemia; cardiovascular disease; degenerative disease; depression; drug structure; drug targeting; enzyme inhibition; enzyme mechanism; human; major depression; malignant neoplasm; multiple sclerosis; nerve degeneration; nonhuman; Parkinson disease; pathophysiology; protein blood level; Review; schizophrenia; therapy effect; aging; animal; degenerative disease; drug effect; metabolism ⓘ English 2020 2020-03 10.1038/s12276-020-0399-8 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ SUMO and cellular adaptive mechanisms ⓘ Stress response: how cells wrestle with SUMO disruption Cellular stress caused by disrupting attachment of the ubiquitous small ubiquitin-like modifier (SUMO) proteins, which are present in most organisms and regulate numerous DNA processes and stress responses by attaching to key proteins, results in some remarkable adaptations. Mark Hochstrasser at Yale University, New Haven, USA, and co-workers review how this "sumoylation" is reversed by protease enzymes, and how imbalances between sumoylation and desumoylation may be linked to diseases including cancer. When certain SUMO proteases are deliberately disrupted, the cells quickly become aneuploid, i.e., carry an abnormal number of chromosomes. These cells show severe growth defects, but over many generations they regain the normal number of chromosomes. They also undergo genetic changes that promote alternative mechanisms that compensate for losing the SUMO protease and facilitate the same efficient stress responses as the original cells. The ubiquitin family member SUMO is a covalent regulator of proteins that functions in response to various stresses, and defects in SUMO-protein conjugation or deconjugation have been implicated in multiple diseases. The loss of the Ulp2 SUMO protease, which reverses SUMO-protein modifications, in the model eukaryoteSaccharomyces cerevisiaeis severely detrimental to cell fitness and has emerged as a useful model for studying how cells adapt to SUMO system dysfunction. Both short-term and long-term adaptive mechanisms are triggered depending on the length of time cells spend without this SUMO chain-cleaving enzyme. Such short-term adaptations include a highly specific multichromosome aneuploidy and large changes in ribosomal gene transcription. While aneuploidulp2 Delta cells survive, they suffer severe defects in growth and stress resistance. Over many generations, euploidy is restored, transcriptional programs are adjusted, and specific genetic changes that compensate for the loss of the SUMO protease are observed. These long-term adapted cells grow at normal rates with no detectable defects in stress resistance. In this review, we examine the connections between SUMO and cellular adaptive mechanisms more broadly. ⓘ Ryu, Hong-Yeoul; Ahn, Seong Hoon; Hochstrasser, Mark ⓘ Kyungpook Natl Univ, Coll Natl Sci, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Hanyang Univ, Dept Mol & Life Sci, Coll Sci & Convergence Technol, Ansan 15588, South Korea; Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA ⓘ ⓘ 55889917800; 7401989611; 26643419800 ⓘ mark.hochstrasser@yale.edu; ⓘ EXPERIMENTAL AND MOLECULAR MEDICINE ⓘ EXP MOL MED ⓘ 1226-3613 2092-6413 52 6 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL ⓘ 2020 8.718 9.6 0.52 2025-06-25 ⓘ 32 31 ⓘ HEAT-SHOCK; PROTEIN MODIFICATION; REDOX REGULATION; TOPOISOMERASE-I; STRESS-RESPONSE; TRANSCRIPTION; MUTATION; SUMOYLATION; ANEUPLOIDY; CONJUGATION ⓘ ⓘ Aneuploidy; Animals; Humans; SUMO-1 Protein; protein Ulp2; SUMO protein; unclassified drug; SUMO 1 protein; aneuploidy; cell function; cellular stress response; DNA transposition; enzyme mechanism; evolutionary adaptation; gene amplification; gene mutation; genetic variation; heterozygosity; human; mosaicism; multisite heterozygosity; nonhuman; polyploidy; Review; RNA translation; animal; genetics; metabolism ⓘ English 2020 2020-06 10.1038/s12276-020-0457-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Cyber-Physical Microgrids: Toward Future Resilient Communities ⓘ Microgrids can be isolated from large-scale power transmission/distribution systems (macrogrids) to deliver energy to their local communities using local energy resources and distribution systems when power outages occur in the macrogrids. In such situations, microgrids could be considered the last available resource to provide energy to critical infrastructure. ⓘ Vu, Tuyen V.; Nguyen, Bang L. H.; Cheng, Zheyuan; Chow, Mo-Yuen; Zhang, Bin ⓘ Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA; Florida State Univ, Ctr Adv Power Syst, Res Fac, Tallahassee, FL 32306 USA; Kyungpook Natl Univ, Power Elect & Energy Convers Lab, Daegu, South Korea; North Carolina State Univ, Adv Diag Automat & Control Lab, Raleigh, NC USA; North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC USA; Univ South Carolina, Dept Elect Engn, Columbia, SC 29208 USA; Gen Motors, Detroit, MI USA; Impact Technol, Rochester, NY USA; Georgia Inst Technol, Atlanta, GA 30332 USA ⓘ Vu, Tuyen/A-1863-2018; Nguyen, Bang/U-6579-2019; Cheng, Zheyuan/J-3574-2019; Chow, Mo-Yuen/HPC-3082-2023; Zhang, Bin/AFB-1069-2022 ⓘ ⓘ tvu@clarkson.edu;nguyenbl@clarkson.edu;zcheng3@ncsu.edu;chow@ncsu.edu;zhangbin@cec.sc.edu; ⓘ IEEE INDUSTRIAL ELECTRONICS MAGAZINE ⓘ IEEE IND ELECTRON M ⓘ 1932-4529 1941-0115 14 3 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC ⓘ 2020 6.625 9.7 ⓘ 30 Microgrids; Monitoring; Resilience; Control systems; Market research; Robustness; Power measurement ⓘ DATA-INJECTION ATTACKS; DYNAMIC STATE ESTIMATION; HARMONIC REPETITIVE CONTROL; ARTIFICIAL NEURAL-NETWORKS; INTRUSION DETECTION SYSTEM; POWER GRID RESILIENCE; ANOMALY DETECTION; SMART GRIDS; WIND-SPEED; LOAD ⓘ ⓘ ⓘ English 2020 2020-09 10.1109/mie.2019.2958039 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation ⓘ Background: Recently, several studies suggested potential involvements of alpha-synuclein in Alzheimer's disease (AD) pathophysiology. Higher concentrations of alpha-synuclein were reported in cerebrospinal fluid (CSF) of AD patients with a positive correlation towards CSF tau, indicating its possible role in AD. We analyzed the CSF biomarkers to verify whether alpha-synuclein could be an additional supported biomarker in AD diagnosis. Methods: In this cross-sectional study, CSF samples of 71 early-onset AD, 34 late-onset AD, 11 mild cognitive impairment, 17 subjective cognitive decline, 45 Parkinson's disease, and 32 healthy control (HC) were collected. CSF amyloid-beta 1-42 (A), total tau (N), and phosphorylated tau181 (T) were measured by commercial ELISA kits, and in-house ELISA kit was developed to quantify alpha-synuclein. The cognitive assessments and amyloid-PET imaging were also performed. Results: CSF alpha-synuclein manifested a tendency to increase in AD and to decreased in Parkinson's disease compared to HC. The equilibrium states of total tau and alpha-synuclein concentrations were changed significantly in AD, and the ratio of total tau/alpha-synuclein (N/alpha S) was dramatically increased in AD than HC. Remarkably, N/alpha S revealed a strong positive correlation with tau phosphorylation rate. Also, the combination of N/alpha S with amyloid-beta 1-42/phosphorylated tau181 ratio had the best diagnosis performance (AUC = 0.956, sensitivity = 96%, specificity = 87%). In concordance analysis, N/alpha S showed the higher diagnostic agreement with amyloid-beta 1-42 and amyloid-PET. Analysis of biomarker profiling with N/alpha S had distinctive characteristics and clustering of each group. Especially, among the group of suspected non-Alzheimer's disease pathophysiology, all A-T+N+ patients with N/alpha S+ were reintegrated into AD. Conclusions: The high correlation of alpha-synuclein with tau and the elevated N/alpha S in AD supported the involvement of alpha-synuclein in AD pathophysiology. Importantly, N/alpha S improved the diagnostic performance, confirming the needs of incorporating alpha-synuclein as a biomarker for neurodegenerative disorders. The incorporation of a biomarker group [N/alpha S] could contribute to provide better understanding and diagnosis of neurodegenerative disorders. ⓘ Shim, Kyu Hwan; Kang, Min Ju; Suh, Jee Won; Pyun, Jung-Min; Ryoo, Nayoung; Park, Young Ho; Youn, Young Chul; Jang, Jae-Won; Jeong, Jee Hyang; Park, Kyung Won; Choi, Seong Hye; Suk, Kyoungho; Lee, Ho-Won; Ko, Pan-Woo; Lee, Chan-Nyoung; Lim, Tae-Sung; An, Seong Soo A.; Kim, SangYun ⓘ Vet Hlth Serv Med Ctr, Dept Neurol, Vet Med Res Inst, Seoul, South Korea; Seoul Natl Univ, Dept Neurol, Bundang Hosp, Seongnam Si, Gyeonggi Do, South Korea; Seoul Natl Univ, Coll Med, Seongnam Si, Gyeonggi Do, South Korea; Chung Ang Univ Hosp, Dept Neurol, Seoul, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Neurol, Sch Med, Chouncheon, South Korea; Ewha Womans Univ, Dept Neurol, Mokdong Hosp, Seoul, South Korea; Dong A Univ, Dept Neurol, Coll Med, Busan, South Korea; Inst Convergence Biohlth, Busan, South Korea; Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; Kyungpook Natl Univ, Dept Pharmacol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Neurol, Sch Med, Daegu, South Korea; Korea Univ Med, Dept Neurol, Seoul, South Korea; Ajou Univ, Dept Neurol, Sch Med, Suwon, South Korea; Gachon Univ, Dept Bionano Technol, Seongnam Si, Gyeonggi Do, South Korea ⓘ ; An, Seong Soo/AFR-4832-2022; Kim, Sang/J-5400-2012; Youn, Young Chul/ABA-9938-2021 ⓘ 57203010673; 57199501012; 57202877348; 57199505060; 57217072681; 55494470700; 9272947400; 56457145600; 7402045750; 55722191100; 15838894900; 7005114595; 35337240700; 55543341200; 54179516000; 15725604700; 14619086700; 7601593906 ⓘ seong.an@gmail.com;neuroksy@snu.ac.kr; ⓘ ALZHEIMERS RESEARCH & THERAPY ⓘ ALZHEIMERS RES THER ⓘ 1758-9193 12 1 SCIE CLINICAL NEUROLOGY;NEUROSCIENCES ⓘ 2020 6.982 9.9 1.28 2025-06-25 ⓘ 20 24 Alzheimer's disease; Cerebrospinal fluid; Tau; alpha-Synuclein; Biomarker ⓘ ALPHA-SYNUCLEIN; CEREBROSPINAL-FLUID; COGNITIVE DECLINE; LEWY BODIES; A-BETA; DEMENTIA; ASSOCIATION; PREVALENCE; PATHOLOGY ⓘ Alzheimer's disease; Biomarker; Cerebrospinal fluid; Tau; α-Synuclein ⓘ alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cross-Sectional Studies; Humans; Peptide Fragments; Phosphorylation; tau Proteins; alpha synuclein; amyloid beta protein[1-42]; florbetapir f 18; tau protein; alpha synuclein; amyloid beta protein; biological marker; peptide fragment; tau protein; adult; aged; Alzheimer disease; Article; cerebrospinal fluid analysis; cognitive defect; computer assisted tomography; controlled study; cross-sectional study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; differential diagnosis; enzyme linked immunosorbent assay; female; human; major clinical study; male; mild cognitive impairment; Parkinson disease; positron emission tomography; priority journal; protein phosphorylation; quantitative analysis; receiver operating characteristic; sensitivity and specificity; metabolism; phosphorylation ⓘ English 2020 2020-07-13 10.1186/s13195-020-00648-9 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A completely explicit scheme of Cauchy problem in BSLM for solving the Navier-Stokes equations ⓘ This paper presents a backward semi-Lagrangian method (BSLM) with third-order convergence in both time and space for solving incompressible Navier-Stokes equations. The third-order backward differentiation formula for the total time derivative and the projection method for the steady-state Stokes equation are used. A fourth-order difference scheme together with a local bi-cubic interpolation is used to solve the resulted two governing equations for the velocity and pressure. This paper mainly focuses on the development of an efficient scheme for solving the nonlinear Cauchy problem of the characteristic curve. We employ a modified linear multi-step method of the implicit-type based on the error correction strategy. A novel contribution of this paper is the design of a completely explicit formula for the three foot-points. The proposed method is superior to existing methods in terms of computational costs and accuracy, allowing the use of a large time step size. The fully explicit formula for the foot-points significantly improves the performance of a common BSLM for a wide range of practical applications. (C) 2019 Elsevier Inc. All rights reserved. ⓘ Kim, Philsu; Kim, Dojin; Piao, Xiangfan; Bak, Soyoon ⓘ Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Pusan Natl Univ, Dept Math, Busan 46241, South Korea ⓘ Bak, Soyoon/HSE-8486-2023 ⓘ 7402334786; 57206696832; 54906916500; 56450371300 ⓘ kimps@knu.ac.kr;kimdojin@pusan.ac.kr;piaoxf76@hanmail.net;jiya525@knu.ac.kr; ⓘ JOURNAL OF COMPUTATIONAL PHYSICS ⓘ J COMPUT PHYS ⓘ 0021-9991 1090-2716 401 SCIE COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;PHYSICS, MATHEMATICAL ⓘ 2020 3.553 10.0 0.88 2025-06-25 ⓘ 10 11 Backward semi-Lagrangian method; Projection method; BDF3; Navier-Stokes equations; Cauchy problem ⓘ SEMI-LAGRANGIAN SCHEME; ORDER CHARACTERISTICS/FINITE ELEMENTS; DIFFUSION-REACTION PROBLEMS; FINITE-ELEMENT; NUMERICAL-ANALYSIS; PROJECTION METHOD; 2ND-ORDER; TIME; FLOW; SIMULATION ⓘ Backward semi-Lagrangian method; BDF3; Cauchy problem; Navier–Stokes equations; Projection method ⓘ Equations of state; Error correction; Lagrange multipliers; Backward semi-lagrangian method; BDF3; Cauchy problems; Explicit formula; Explicit scheme; Incompressible (Navier )Stokes equation; Navier-Stokes equation; Projection method; Semi-Lagrangian methods; Third-order convergence; Navier Stokes equations ⓘ English 2020 2020-01-15 10.1016/j.jcp.2019.109028 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An efficient trajectory tracking algorithm for the backward semi-Lagrangian method of solving the guiding center problems ⓘ In this paper, we develop an effective numerical algorithm that tracks the trajectory needed to solve guiding center models using the backward semi-Lagrangian method. In terms of numerical calculations, two appreciably fast algorithms for the departure points are designed. One is a completely explicit formula for numerical solutions of the discrete system for each Cauchy problem. This formula is characterized by numerical factors that are less than half the multiplication number used in the usual Gaussian elimination. The other finds the required departure points with an interpolation method that is at least 30% less expensive for heavy Cauchy problems. Last, we propose a method to modify the solution to improve estimation of physical quantities, such as conservation of mass, which can be lost in interpolation solutions calculated at the departure points. It turns out that the proposed method not only saves a great deal of computation time, but also preserves physical quantities such as mass and total kinetic energy much better than conventional methods. To demonstrate the numerical evidence, we use the proposed method to simulate several problems such as the incompressible Euler equation, Kelvin-Helmholtz instability, Diocotron instability and a three-dimensional guiding center model. (C) 2020 Elsevier Inc. All rights reserved. ⓘ Piao, Xiangfan; Kim, Philsu ⓘ Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea ⓘ ⓘ 54906916500; 7402334786 ⓘ piaoxf76@hanmail.net;kimps@knu.ac.kr; ⓘ JOURNAL OF COMPUTATIONAL PHYSICS ⓘ J COMPUT PHYS ⓘ 0021-9991 1090-2716 418 SCIE COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;PHYSICS, MATHEMATICAL ⓘ 2020 3.553 10.0 0.39 2025-06-25 ⓘ 4 4 Backward semi-Lagrangian method; Guiding center model; Divergence free ⓘ ORDER CHARACTERISTICS/FINITE ELEMENTS; DIFFUSION-REACTION PROBLEMS; NUMERICAL-ANALYSIS; GALERKIN METHOD; SCHEME; TIME; INTEGRATION; 2ND-ORDER; ADVECTION ⓘ Backward semi-Lagrangian method; Divergence free; Guiding center model ⓘ Kinetic energy; Kinetics; Lagrange multipliers; Numerical methods; Three dimensional computer graphics; Tracking (position); Backward semi-lagrangian method; Cauchy problems; Center problems; Divergence free; Guiding center model; Guiding centers; Physical quantities; Semi-Lagrangian methods; Tracking algorithm; Trajectory-tracking; Interpolation ⓘ English 2020 2020-10-01 10.1016/j.jcp.2020.109664 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Design and prediction of dye dispersibility stabilized by polymeric dispersants using a Dye-Monomer interaction force measurement ⓘ In this study, we propose a dye-monomer interaction force measurement technique based on atomic force microscopy (AFM) to predict the performance of polymeric dispersants. Cantilevers modified with functional monomers such as styrene, N-butyl acrylate (BA), and 2-(N-phthalimido)ethyl methacrylate (PEMA) were used to characterize the interaction force between these functional monomers and a target dye (Disperse Blue 359). The interaction forces of each monomer-styrene, BA, and PEMA-with Disperse Blue 359 were measured as 10.75 nN, 7.06 nN, and 21.31 nN, respectively, and their trend was consistent with dipole-moment values obtained from density function theory (DFT) calculations (p(styrene) = 0.0001, mu(PEMA) = 2.3158, mu(Disperse Blue 359) = 3.0368). We synthesized a series of model polymers containing specific functional monomers (CoPS10, CoBA, CoPPEMAs) with similar molecular weights, molecular-weight distributions, and acid contents and compared their actual performance with that predicted from interaction force measurement data. The results were well correlated with the interaction force measurement data. The effect of the PEMA content on dye dispersion stability was also investigated; the results indicated that both the PEMA content and the type of dye-interacting group greatly influenced the characteristics of the dispersion. ⓘ Kim, Gi Young; Perumal, Suguna; Kim, Soon Cheon; Lee, Sang-Ho; Noh, Seung Man; Park, Young Il; Cheong, In Woo; Kim, Jin Chul ⓘ Korea Res Inst Chem Technol, Res Ctr Green Fine Chem, Ulsan 44412, South Korea; Kyungpook Natl Univ, Sch Appl Chem, Daegu 41566, South Korea ⓘ Kim, Kyoung-Sook/A-7768-2017; perumal, suguna/N-9075-2017; Lee, Sang-Ho/T-3699-2019 ⓘ 57210997221; 56673798900; 57196401694; 58743026900; 36941192100; 55494480300; 7006733373; 56805502600 ⓘ jckim81@krict.re.kr; ⓘ DYES AND PIGMENTS ⓘ DYES PIGMENTS ⓘ 0143-7208 1873-3743 172 SCIE CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, TEXTILES ⓘ 2020 4.889 10.0 0.7 2025-06-25 ⓘ 15 19 Force microscopy; Polymeric dispersant; Disperse dye; Dispersibility ⓘ PIGMENT ⓘ Disperse dye; Dispersibility; Force microscopy; Polymeric dispersant ⓘ Disperse Dyes; Dispersions; Force; Measurement; Molecular Weight Distribution; Monomers; Polymers; Styrene; Atomic force microscopy; Density functional theory; Design for testability; Dispersions; Force measurement; Molecular weight distribution; Probability density function; Styrene; Density function theory calculations; Disperse dyes; Dispersibilities; Dispersion stability; Ethyl methacrylates; Force microscopy; Polymeric dispersant; Polymeric dispersants; Polymers ⓘ English 2020 2020-01 10.1016/j.dyepig.2019.107791 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Facile Synthetic Route To Prepare Ultrathin Silver Nanosheets by Reducing Silver Thiolates in Interlayer Surface of Layered Double Hydroxides ⓘ Silver metal nanostructures have gained much interest, due to their utility in various fields, based on their unique properties at nanosize. Tremendous research efforts have been made to establish synthetic methods to manipulate their shape and size. The most challenging synthesis in silver nanostructures has been known as a plate-like shape having a few nanometers size thickness and high aspect ratio. Here, we demonstrate a novel and facile synthetic route for ultrathin (<= 1 nm) silver nanosheets using silver carboxylthiolate as precursor. Such silver thiolate formed single-layered colloid in aqueous basic solution, due to the electrostatic repulsion between carboxylate groups. These single layers of silver thiolates were stabilized within the interlayer space of layered double hydroxide (LDH). When silver thiolates confined in LDHs were calcined under reductive atmosphere, the LDHs effectively suppressed the vertical growth of silver crystals. ⓘ Gwak, Gyeong-Hyeon; Kim, Min-Kyu; Lee, Won-Jae; Jeung, Do-Gak; Park, Jin Kuen; Paek, Seung-Min; Oh, Jae-Min ⓘ Pohang Univ Sci & Technol, Beamline Res Div, Pohang Accelerator Lab, Pohang 37673, Gyeongsangbukdo, South Korea; Dongguk Univ Seoul, Dept Energy & Mat Engn, Seoul 04620, South Korea; Univ South Australia, Future Ind Inst, Div Informat Technol Engn & Environm, Mawson Lakes, SA 5095, Australia; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Hankuk Univ Foreign Studies, Dept Chem, Yongin 17035, Gyeonggi Do, South Korea ⓘ ; Gwak, Gyeong-Hyeon/B-6680-2016; Paek, Seung-Min/E-4667-2011 ⓘ 55452156500; 57201126983; 57203094506; 57211288466; 55085701500; 7102686289; 7402155053 ⓘ jinkpark@hufs.ac.kr;smpaek@knu.ac.kr;jaemin.oh@dongguk.edu; ⓘ INORGANIC CHEMISTRY ⓘ INORG CHEM ⓘ 0020-1669 1520-510X 59 4 SCIE CHEMISTRY, INORGANIC & NUCLEAR ⓘ 2020 5.165 10.0 0.76 2025-06-25 ⓘ 12 12 ⓘ SHAPE; GROWTH; NANOPARTICLE; NANOWIRES; NANORODS; FILMS ⓘ ⓘ ⓘ English 2020 2020-02-17 10.1021/acs.inorgchem.9b02694 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ INFORMATION AND COMMUNICATION TECHNOLOGY-BASED CENTRALIZED MONITORING SYSTEM TO INCREASE ADHERENCE TO IMMUNOSUPPRESSIVE MEDICATION IN KIDNEY TRANSPLANT RECIPIENTS: A RANDOMIZED CONTROLLED TRIAL ⓘ ⓘ Jung, Hee-Yeon; Jeon, Yena; Seong, Sook Jin; Seo, Jung Ju; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan Duck; Yoon, Young-Ran; Yoon, Se-Hee; Lee, Jong Soo; Kim, Yong-Lim ⓘ Kyungpook Natl Univ Hosp, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Stat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Sci & Clin Trial Ctr, Daegu, South Korea; Konyang Univ, Coll Med, Internal Med, Nonsan, South Korea; Univ Ulsan, Coll Med, Internal Med, Ulsan, South Korea ⓘ Kim, Yong-Lim/AGK-3172-2022; Park, Sun-Hee/LMN-0033-2024; Kim, Hyoungnae/JXN-1329-2024; Yoon, Young-Ran/GLT-0172-2022 ⓘ ⓘ ⓘ NEPHROLOGY DIALYSIS TRANSPLANTATION ⓘ NEPHROL DIAL TRANSPL ⓘ 0931-0509 1460-2385 35 SCIE TRANSPLANTATION;UROLOGY & NEPHROLOGY ⓘ 2020 5.992 10.0 ⓘ 1 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 ⓘ 바로가기 바로가기
○ Meeting Abstract ⓘ MAP KINASES-REGULATED PROTEINS IN SIGNALING PATHWAYS OF VASOPRESSIN IN KIDNEY COLLECTING DUCT ⓘ ⓘ Jang, Hyo-Ju; Jung, Hyun Jun; Han, Si-Yoon; Choi, Hyo-Jung; Park, Eui-Jung; Park, Hye-Jeong; Kwon, Tae-Hwan ⓘ Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu, South Korea; Johns Hopkins Univ, Sch Med, Dept Med, Div Nephrol, Baltimore, MD 21205 USA ⓘ Jung, Hyun Jun/LKM-4480-2024; Park, Hye/C-1648-2013 ⓘ ⓘ ⓘ NEPHROLOGY DIALYSIS TRANSPLANTATION ⓘ NEPHROL DIAL TRANSPL ⓘ 0931-0509 1460-2385 35 SCIE TRANSPLANTATION;UROLOGY & NEPHROLOGY ⓘ 2020 5.992 10.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 ⓘ 바로가기 바로가기
○ Meeting Abstract ⓘ MYCOPHENOLIC ACID TROUGH CONCENTRATION AND DOSE ARE ASSOCIATED WITH HEMATOLOGIC ABNORMALITIES BUT NOT REJECTION IN KIDNEY TRANSPLANT RECIPIENTS ⓘ ⓘ Jung, Hee-Yeon; Lee, Sukyung; Jeon, Yena; Lim, Jeong-Hoon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan Duck ⓘ Kyungpook Natl Univ Hosp, Internal Med, Daegu, South Korea; Pohang St Marys Hosp, Internal Med, Pohang, South Korea; Kyungpook Natl Univ, Stat, Daegu, South Korea ⓘ Kim, Yong-Lim/AGK-3172-2022; Kim, Hyoungnae/JXN-1329-2024; Park, Sun-Hee/LMN-0033-2024; LIM, JEONG HOON/HPC-3775-2023 ⓘ ⓘ ⓘ NEPHROLOGY DIALYSIS TRANSPLANTATION ⓘ NEPHROL DIAL TRANSPL ⓘ 0931-0509 1460-2385 35 SCIE TRANSPLANTATION;UROLOGY & NEPHROLOGY ⓘ 2020 5.992 10.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 ⓘ 바로가기 바로가기
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