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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Multiplexed PLGA scaffolds with nitric oxide-releasing zinc oxide and melatonin-modulated extracellular vesicles for severe chronic kidney disease ⓘ Introduction: With prevalence of chronic kidney disease (CKD) in worldwide, the strategies to recover renal function via tissue regeneration could provide alternatives to kidney replacement therapies. However, due to relatively low reproducibility of renal basal cells and limited bioactivities of implanted biomaterials along with the high probability of substance-inducible inflammation and immunogenicity, kidney tissue regeneration could be challenging. Objectives: To exclude various side effects from cell transplantations, in this study, we have induced extracellular vesicles (EVs) incorporated cell-free hybrid PMEZ scaffolds. Methods: Hybrid PMEZ scaffolds incorporating essential bioactive components, such as ricinoleic acid grafted Mg(OH)2 (M), extracellular matrix (E), and alpha lipoic acid-conjugated ZnO (Z) based on biodegradable porous PLGA (P) platform was successfully manufactured. Consecutively, for functional improvements, melatonin-modulated extracellular vesicles (mEVs), derived from the human umbilical cord MSCs in chemically defined media without serum impurities, were also loaded onto PMEZ scaffolds to construct the multiplexed PMEZ/mEV scaffold. Results: With functionalities of Mg(OH)2 and extracellular matrix-loaded PLGA scaffolds, the continuous nitric oxide-releasing property of modified ZnO and remarkably upregulated regenerative functionalities of mEVs showed significantly enhanced kidney regenerative activities. Based on these, the structural and functional restoration has been practically achieved in 5/6 nephrectomy mouse models that mimicked severe human CKD. Conclusion: Our study has proved the combinatory bioactivities of the biodegradable PLGA-based multiplexed scaffold for kidney tissue regeneration in 5/6 nephrectomy mouse representing a severe CKD model. The optimal microenvironments for the morphogenetic formations of renal tissues and functional restorations have successfully achieved the combinatory bioactivities of remarkable components for PMEZ/mEV, which could be a promising therapeutic alternative for CKD treatment. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article ⓘ Rhim, Won-Kyu; Woo, Jiwon; Kim, Jun Yong; Lee, Eun Hye; Cha, Seung-Gyu; Kim, Da-Seul; Baek, Seung-Woon; Park, Chun Gwon; Kim, Bum Soo; Kwon, Tae Gyun; Han, Dong Keun ⓘ CHA Univ, Dept Biomed Sci, 335 Pangyo Ro, Seongnam Si 13488, Gyeonggi Do, South Korea; Sungkyunkwan Univ SKKU, SKKU Inst Convergence, Dept Intelligent Precis Healthcare Convergence, 2066 Seobu Ro, Suwon 16419, Gyeonggi Do, South Korea; Sungkyunkwan Univ SKKU, SKKU Inst Convergence, Intelligent Precis Healthcare Convergence, 2066 Seobu ro, Suwon 16419, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41944, South Korea ⓘ Baek, Seung-Woon/IWD-8881-2023; Kim, Jun Yong/MBG-4766-2025 ⓘ 36825029800; 57312341700; 57214807525; 57189661699; 57312341800; 57195566876; 57216178574; 40361321700; 57202817150; 15073765400; 7403219478 ⓘ dkhan@cha.ac.kr; ⓘ JOURNAL OF ADVANCED RESEARCH ⓘ J ADV RES ⓘ 2090-1232 2090-1224 69 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2024 13 7.8 0 2025-05-07 ⓘ 3 3 PMEZ scaffold; ZnO; Melatonin-modulated extracellular vesicles; (mEVs); Nitric oxide (NO); Kidney regeneration ⓘ MESENCHYMAL STEM-CELLS; GROWTH-FACTOR; ISCHEMIA-REPERFUSION; LUNG INJURY; ANGIOGENESIS; APOPTOSIS; REGENERATION; ACTIVATION; MATRIX ⓘ Kidney regeneration; Melatonin-modulated extracellular vesicles (mEVs); Nitric oxide (NO); PMEZ scaffold; ZnO ⓘ Animals; Disease Models, Animal; Extracellular Vesicles; Humans; Kidney; Male; Melatonin; Mesenchymal Stem Cells; Mice; Nitric Oxide; Polylactic Acid-Polyglycolic Acid Copolymer; Regeneration; Renal Insufficiency, Chronic; Tissue Engineering; Tissue Scaffolds; Zinc Oxide; melatonin; nitric oxide; polyglactin; zinc oxide; animal; chemistry; chronic kidney failure; disease model; drug effect; exosome; human; kidney; male; mesenchymal stem cell; metabolism; mouse; procedures; regeneration; therapy; tissue engineering; tissue scaffold ⓘ English 2025 2025-03 10.1016/j.jare.2024.03.018 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ P0876 One-year effectiveness and safety of ustekinumab treatment in patients with ulcerative colitis: An Asan-Crohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD) multicentre real-world cohort study ⓘ ⓘ Baek, J. E.; Kim, M. K.; Kim, E. S.; Kim, K. O.; Jo, H. H.; Hwang, S. W.; Park, S. H.; Jang, B., I; Kim, E. Y.; Yang, S. K.; Kim, S. K.; Ye, B. D. ⓘ Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, Seoul, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Internal Med, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Inflammatory Bowel Dis Ctr, Seoul, South Korea ⓘ Jo, Hyeong Ho/LFU-2981-2024; Ye, Byong/AAF-4955-2020 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 19 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2024 8.7 7.8 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-01-22 10.1093/ecco-jcc/jjae190.1050 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery ⓘ Background: Doxorubicin (Dox) is a potent anticancer agent; however, its therapeutic efficacy is constrained by a narrow therapeutic index, resulting in nonselective cardiotoxicity and nephrotoxicity. To improve its specificity and therapeutic efficacy, multivalent targeting strategies are being developed. Methods: A chimeric polypeptide consisting of an elastin-like polypeptides (ELP) copolymer with a repeating IL-4 receptor-specific targeting peptide, AP-1, and a (GGCGSCGSC)2 sequence encoding 6 cysteine residues (C6) at the carboxyl-terminus for Dox conjugation was designed. Several AP1-ELPs of varying molecular sizes and structures, ranging from unimers to micelle-forming polymers, were characterized to evaluate their influence on Dox delivery and tumor inhibition. Results: Conjugating Dox to the C6 via an acid-labile linker induced self-assembly into micelle-like structures at body temperature. The size of these multivalent constructs significantly influenced their tumor penetration and overall therapeutic outcomes. High molecular weight, micelle-forming AP1-ELP constructs demonstrated faster tumor entry and enhanced inhibition compared to lower molecular weight linear AP1-ELPs. Tumor uptake of Dox was five times greater than that of free drug and twice that of low molecular weight, linear AP1-ELPs. Furthermore, systemic administration of these high molecular weight constructs effectively inhibited tumor growth in breast carcinoma xenograft models without inducing specific organ toxicity. Conclusion: Outperforming free Dox, high molecular weight micelle-forming AP1-ELP constructs achieve superior tumor targeting and efficacy with minimal toxicity, highlighting their potential as safer and more promising carriers for targeted drug delivery. ⓘ Lee, Young-Jin; Hong, Jisan; Seo, Bo-Yeon; Lee, Byung-Heon; Sarangthem, Vijaya; Park, Rang-Woon ⓘ Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea ⓘ Sarangthem, Vijaya/AAX-7421-2020 ⓘ 57191967618; 59149067400; 57191958798; 16304374900; 56001741200; 7401895636 ⓘ devi1703@gmail.com; nwpark@knu.ac.kr; ⓘ INTERNATIONAL JOURNAL OF NANOMEDICINE ⓘ INT J NANOMED ⓘ 1178-2013 20 SCIE NANOSCIENCE & NANOTECHNOLOGY;PHARMACOLOGY & PHARMACY ⓘ 2024 6.5 7.8 0 2025-06-11 ⓘ 0 0 doxorubicin; tumor-targeting; elastin-like polypeptide; multivalent targeting; IL-4 receptor; AP1-ELPs; size dependency; tumor penetration; therapeutic efficacy; AP1-ELP-Dox ⓘ ELASTIN-LIKE POLYPEPTIDES; DRUG-DELIVERY; THERAPEUTIC-EFFICACY; MULTIVALENT LIGANDS; MOLECULAR-WEIGHT; DESIGN; BIODISTRIBUTION; ACCUMULATION; DENDRIMERS; SYSTEMS ⓘ AP1-ELP-Dox; AP1-ELPs; doxorubicin; elastin-like polypeptide; IL-4 receptor; multivalent targeting; size dependency; therapeutic efficacy; tumor penetration; tumor-targeting ⓘ Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Elastin; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Peptides; Receptors, Interleukin-4; Xenograft Model Antitumor Assays; alanine aminotransferase; aspartate aminotransferase; creatine kinase; creatinine; doxorubicin; elastin like polypeptide; hemoglobin; interleukin 4; interleukin 4 receptor; lactate dehydrogenase; nanoparticle; polypeptide; transcription factor AP 1; unclassified drug; antineoplastic agent; antineoplastic antibiotic; doxorubicin; drug carrier; elastin; interleukin 4 receptor; nanoparticle; peptide; animal cell; animal tissue; Article; blood analysis; body weight; breast carcinoma; cardiac muscle injury; cardiotoxicity; cell death; cell population; controlled study; cytotoxicity; endocytosis; erythrocyte count; female; flow cytometry; hemolysis assay; human; human cell; injury; leukocyte count; mass spectrometry; MDA-MB-231 cell line; mouse; NCI-H226 cell line; nonhuman; photon correlation spectroscopy; platelet count; protein expression; survival rate; tumor growth; tumor volume; TUNEL assay; urea nitrogen blood level; animal; Bagg albino mouse; breast tumor; chemistry; drug delivery system; drug screening; drug therapy; metabolism; micelle; nude mouse; procedures; tumor cell line ⓘ English 2025 2025 10.2147/ijn.s513336 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Tasty & Healthy Flexible Diet Induces clinical and biological Remission in Children and Young Adults with Mild-Moderate Crohn's Disease similar to EEN: results from the "TASTI-MM" randomized, physician-blinded, controlled trial ⓘ ⓘ Aharoni Frutkoff, Y.; Plotkin, L.; Shavit, Z.; Focht, G.; Livovsky, J.; Lev-Zion, R.; Ledder, O.; Assa, A.; Yogev, D.; Orlanski-Meyer, E.; Broide, E.; Kierkus, J.; Kang, B.; Weiss, B.; Aloi, M.; Schwerd, T.; Shouval, D.; Griffiths, A.; Turner, D. ⓘ Shaare Zedek Med Ctr, Juliet Keidan Inst Pediat Gastroenterol & Nutr, Jerusalem, Israel; Assaf Harofeh Med Ctr, Pediat Gastroenterol Unit, Zerifin, Israel; Childrens Mem Hlth Inst, Pediat Gastroenterol Unit, Warsaw, Poland; Kyungpook Natl Univ, Pediat Gastroenterol Unit, Daegu, South Korea; Sheba Med Ctr, Pediat Gastroenterol Unit, Ramat Gan, Israel; Sapienza Univ, Pediat Gastroenterol, Rome, Italy; LMU, Dr Hauner Childrens Hosp, Munich, Germany; Schneider Childrens Med Ctr, Pediat Gastroenterol Unit, Petah Tiqwa, Israel; Hosp Sick Children, Pediat Gastroenterol Unit, Toronto, ON, Canada ⓘ ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 19 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2024 8.7 7.8 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-01-22 10.1093/ecco-jcc/jjae190.0002 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Uncontrolled clinical activity and anti-TNF plus thiopurine combination therapy are predictive factors of 1-year infection risk following acute severe ulcerative colitis: AOCC and ANZIBDC collaboration study ⓘ ⓘ Kim, S. J.; Kim, D. H.; Park, S. H.; Kim, K. O.; Jang, B., I; Kim, D. S.; Lee, Y. J.; Song, E. M.; Lee, H. S.; Kim, E. S.; Yang, C. H.; Sagami, S.; Kobayashi, T.; Mak, J.; Liu, J.; Cao, Q.; Lin, C. C.; Lin, W. C.; Hsu, W. G.; Wei, S. C.; Rice, K.; An, Y. K.; Begun, J.; Ruddick-Collins, L.; Fernandes, R. G.; Robert, G.; Vasudevan, A.; Zhang, J.; Brownson, A.; Ngoi, B.; Kate, L.; Haifer, C.; Bracken, L. M. L.; Swe, E.; Wright, E.; Clark, N.; Schildkraut, T.; Mahy, G.; Moore, G.; Garg, M. ⓘ Chosun Univ, Coll Med, Internal Med, Gwangju, South Korea; Chonnam Natl Univ Hosp, Internal Med, Gwangju, South Korea; Univ Ulsan, Asan Med Ctr, Gastroenterol & Inflammatory Bowel Dis Ctr, Coll Med, Seoul, South Korea; Yeungnam Univ Hosp, Internal Med, Daegu, South Korea; Konyang Univ Hosp, Internal Med, Deajeon, South Korea; Keimyung Univ Hosp, Internal Med, Daegu, South Korea; Ewha Womans Univ, Internal Med, Seoul Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Internal Med, Daegu, South Korea; Daegu Catholic Univ, Chilgok Catholic Hosp, Internal Med, Daegu, South Korea; Univ Kitasato Inst Hosp, Ctr Adv IBD Res & Treatment Kitasato, Tokyo, Japan; Chinese Univ Hong Kong, Gastroenterol, Hong Kong, Peoples R China; Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Ctr Inflammatory Bowel Dis,Gastroenterol, Hangzhou, Peoples R China; Taipei Vet Gen Hosp, Gastroenterol, Taipei, Taiwan; Mackay Mem Hosp, Gastroenterol, Taipei, Taiwan; Kaohsiung Med Univ, Gastroenterol, Kaohsiung, Taiwan; Natl Taiwan Univ, Natl Taiwan Univ Hosp, Internal Med, Taipei, Taiwan; Mater Hosp, Gastroenterol, Brisbane, Australia; Univ Queensland, Mater Res Inst, Gastroenterol, Brisbane, Australia; Eastern Hlth, Gastroenterol, Melbourne, Australia; Te Whatu Ora Southern Dunedin Hosp, Gastroenterol, Dunedin, New Zealand; Royal Adelaide Hosp, Gastroenterol, Adelaide, Australia; St Vincents Hosp Sydney, Gastroenterol, Sydney, Australia; Townsville Univ Hosp, Gastroenterol, Townsville, NC USA; St Vincents Hosp Melbourne, Gastroenterol, Melbourne, Australia; Monash Hlth, Melbourne, Australia; Monash Univ, Gastroenterol, Melbourne, Australia; Northern Hosp, Gastroenterol, Epping, Australia ⓘ Fernandes, Richard/IYT-0155-2023; An, Yoon-Kyo/AAV-2664-2020 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 19 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2024 8.7 7.8 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-01-22 10.1093/ecco-jcc/jjae190.0401 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Upadacitinib for induction of remission in pediatric Crohn's disease: An international multicenter study ⓘ ⓘ Yerushalmy-Feler, A.; Spencer, E. A.; Dolinger, M. T.; Suskind, D. L.; Mitrova, K.; Hradsky, O.; Conrad, M. A.; Kelsen, J. R.; Uhlig, H. H.; Tzivinikos, C.; Henderson, P.; Wlazlo, M.; Hackl, L.; Shouval, D. S.; Bramuzzo, M.; Urlep, D.; Olbjorn, C.; D'Arcangelo, G.; Pujol-Muncunill, G.; Yogev, D.; Kang, B.; Gasparetto, M.; Rungoe, C.; Kolho, K. L.; Hojsak, I; Norsa, L.; Rinawi, F.; Sansotta, N.; Rimon, R. Magen; Granot, M.; Scarallo, L.; Trindade, E.; Rodriguez-Belvis, M. Velasco; Turner, D.; Cohen, S. ⓘ Tel Aviv Univ, Sackler Fac Med, Dana Dwek Childrens Hosp, Pediat Orthoped Dept,Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel; Tel Aviv Univ, Pediat Gastroenterol Inst, Fac Med & Hlth Sci, Tel Aviv, Israel; Icahn Sch Med Mt Sinai, Susan & Leonard Feinstein IBD Clin Ctr, Susan & Leonard Feinstein IBD Clin Ctr, New York, NY USA; Univ Washington, Med Ctr, Div Gastroenterol, Seattle, WA USA; Charles Univ Prague, Fac Med 2, Prague, Czech Republic; Motol Univ Hosp, Dept Paediat, Prague, Czech Republic; Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA USA; Univ Oxford, Biomed Res Ctr, Natl Inst Hlth Res NIHR Comprehens Biomed Res Ctr, Dept Paediat,Translat Gastroenterol Unit, Oxford, England; Al Jalila Childrens Specialty Hosp, Pediat Gastroenterol, Dubai, U Arab Emirates; Royal Hosp Children & Young People, Dept Paediat Gastroenterol & Nutr, Edinburgh, Scotland; Childrens Mem Hlth Inst, Dept Gastroenterol Hepatol & Feeding Disorders, Warsaw, Poland; Med Univ Innsbruck, Dept Pediat, Innsbruck, Austria; Tel Aviv Univ, Tel Aviv, Israel; Tel Aviv Univ, Inst Gastroenterol Nutr & Liver Dis, Fac Med, Tel Aviv, Israel; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy; Univ Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, Ljubljana 1000, Slovenia; Akershus Univ Hosp, Dept Paediat & Adolescent Med, Akershus, Norway; Sapienza Univ Rome, Maternal & Child Hlth Dept, Pediat Gastroenterol & Liver Unit, Rome, Italy; Hosp St Joan de Deu, Dept Pediat Gastroenterol Hepatol & Nutr, Barcelona, Spain; Hebrew Univ Jerusalem, Juliet Keidan Inst Pediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Jerusalem, Israel; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Norfolk & Norwich Univ Hosp, Jenny Lind Childrens Hosp, Paediat Urol, Norwich, England; Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark; HUS, Childrens Hosp, Helsinki, Finland; Univ Helsinki, Dept Paediat Gastroenterol, Helsinki, Finland; Univ Zagreb, Med Sch, Childrens Hosp Zagreb, Zagreb 41001, Croatia; Univ Milan, Childrens Hosp Vittore Buzzi, Pediat Dept, Milan, Italy; Emek Med Ctr, IL-17820 Afula, Israel; Fac Med Technion, Pediat Gastroenterol Unit, Afula, Israel; ASST Papa Giovanni XXIII, Pediat Hepatol Gastroenterol & Transplantat, Bergamo, Italy; Ruth Rappaport Childrens Hosp, Rambam Hlth Care Campus, Haifa, Israel; Technion Israel Inst Technol, Pediat Gastroenterol & Nutr Inst, Fac Med, Haifa, Israel; Sheba Med Ctr, Edmond & Lily Safra Childrens Hosp, Pediat Gastroenterol Unit, Sheba Med Ctr Ramat Gan,Pediat Gastroenterol Unit, Ramat Gan, Israel; Meyer Childrens Hosp, Gastroenterol & Nutr Unit, IRCCS, Florence, Italy; Ctr Hosp Univ Sao Joao, Pediat Gastroenterol & Nutr Unit, Porto, Portugal; Hosp Infantil Univ Nino Jesus, Dept Pediat Gastroenterol & Nutr, Madrid, Spain; Hebrew Univ Jerusalem, Juliet Keidan Inst Pediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Eisenberg R&D Author,Juliet Keidan Inst Paediat Ga, Jerusalem, Israel ⓘ Mitrova, Katarina/JJF-8580-2023; Dolinger, Michael/AAU-4784-2021; D'Arcangelo, Giulia/AAC-3474-2019; Magen Rimon, Ramit/HOF-5893-2023; Spencer, Elizabeth/AAE-7409-2022 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 19 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2024 8.7 7.8 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-01-22 10.1093/ecco-jcc/jjae190.0094 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Upadacitinib for induction of remission in pediatric Ulcerative Colitis: An international multicenter study ⓘ ⓘ Yerushalmy-Feler, A.; Spencer, E. A.; Dolinger, M. T.; Suskind, D. L.; Mitrova, K.; Hradsky, O.; Conrad, M. A.; Kelsen, J. R.; Uhlig, H. H.; Tzivinikos, C.; Ancona, S.; Wlazlo, M.; Hackl, L.; Shouval, D. S.; Bramuzzo, M.; Urlep, D.; Olbjorn, C.; D'Arcangelo, G.; Pujol-Muncunill, G.; Yogev, D.; Kang, B.; Gasparetto, M.; Rungo, C.; Kolho, K. L.; Hojsak, I; Norsa, L.; Rinawi, F.; Sansotta, N.; Rimon, R. Magen; Granot, M.; Scarallo, L.; Trindade, E.; Rodriguez-Belvis, M. Velasco; Turner, D.; Cohen, S. ⓘ Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dana Dwek Childrens Hosp, Pediat Gastroenterol Inst, Tel Aviv, Israel; Tel Aviv Univ, Fac Med & Hlth Sci, Pediat Gastroenterol Inst, Tel Aviv, Israel; Icahn Sch Med Mt Sinai, Susan & Leonard Feinstein IBD Clin Ctr, Div Pediat Gastroenterol, New York, NY USA; Univ Washington, Seattle Childrens Hosp IBD Ctr, Med Sch, Seattle, WA 98105 USA; Charles Univ Prague, Prague, Czech Republic; Motol Univ Hosp, Fac Med 2, Dept Paediat, Prague, Czech Republic; Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA USA; Univ Oxford, Translat Gastroenterol Unit, Oxford, England; Al Jalila Childrens Specialty Hosp, Pediat Gastroenterol, Dubai, U Arab Emirates; Royal Hosp Children & Young People, Dept Paediat Gastroenterol & Nutr, Edinburgh, Scotland; Childrens Mem Hlth Inst, Dept Gastroenterol Hepatol Feeding Disorders & Ped, Warsaw, Poland; Med Univ Innsbruck, Dept Pediat 1, Innsbruck, Austria; Schneider Childrens Med Ctr Israel, Tel Aviv, Israel; Tel Aviv Univ, Inst Gastroenterol Nutr & Liver Dis, Fac Med, Tel Aviv, Israel; IRCCS Burlo Garofolo, Pediat Gastroenterol, Inst Maternal & Child Hlth, Trieste, Italy; Univ Childrens Hosp Ljubljana, Dept Gastroenterol Hepatol & Nutr, Ljubljana 1000, Slovenia; Akershus Univ Hosp, Dept Paediat & Adolescent Med, Lorenskog, Norway; Sapienza Univ Rome, Maternal & Child Hlth Dept, Pediat Gastroenterol & Liver Unit, Rome, Italy; Hosp St Joan Deu, Dept Pediat Gastroenterol Hepatol and Nutr, Barcelona, Spain; Hebrew Univ Jerusalem, Juliet Keidan Inst Paediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Jerusalem, Israel; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Univ East Anglia, Norfolk & Norwich Univ Hosp, Jenny Lind Childrens Hosp, Norwich Med Sch Norwich, Norwich, Norfolk, England; Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark; Childrens Hosp HUS, Helsinki, Finland; Univ Helsinki, Dept Paediat Gastroenterol, Helsinki, Finland; Univ Zagreb, Childrens Hosp Zagreb, Med Sch, Zagreb, Croatia; Univ Milan, Childrens Hosp Vittore Buzzi, Pediat Dept, Milan, Italy; Emek Med Ctr, Pediat Gastroenterol Unit, Afula, Israel; Technion Haifa, Fac Med, Afula, Israel; ASST Papa Giovanni XXIII, Pediat Hepatol Gastroenterol & Transplantat, Bergamo, Italy; Ruth Rappaport Childrens Hosp, Rambam Hlth Care Campus, Haifa, Israel; Technion Israel Inst Technol, Pediat Gastroenterol & Nutr Inst, Fac Med, Haifa, Israel; Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Fac Med, Sheba Med Ctr, Ramat Gan, Israel; Meyer Childrens Hosp, Gastroenterol & Nutr Unit, Florence, Italy; Ctr Hosp Univ Sao Joao, Pediat Gastroenterol & Nutr Unit, Porto, Portugal; Hosp Infantil Univ Nino Jesus, Dept Pediat Gastroenterol & Nutr, Madrid, Spain; Hebrew Univ Jerusalem, Juliet Keidan Inst Paediat Gastroenterol & Nutr, Eisenberg R&D Author Shaare Zedek Med Ctr, Jerusalem, Israel ⓘ Mitrova, Katarina/JJF-8580-2023; Magen Rimon, Ramit/HOF-5893-2023; Hradsky, Ondrej/L-5899-2019; D'Arcangelo, Giulia/AAC-3474-2019; Dolinger, Michael/AAU-4784-2021; Spencer, Elizabeth/AAE-7409-2022 ⓘ ⓘ ⓘ JOURNAL OF CROHNS & COLITIS ⓘ J CROHNS COLITIS ⓘ 1873-9946 1876-4479 19 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2024 8.7 7.8 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2025 2025-01-22 10.1093/ecco-jcc/jjae190.0090 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Enhancing clustering representations with positive proximity and cluster dispersion learning ⓘ Contemporary deep clustering approaches often rely on contrastive or non-contrastive techniques to acquire effective representations for clustering tasks. Contrastive methods apply negative pairs to achieve homogenous representations but can introduce class collision problems, potentially compromising clustering performance. In contrast, non-contrastive techniques prevent class collisions but may produce non-uniform representations that lead to clustering collapse. In this work, we propose a novel end-to-end deep clustering approach named PIPCDR, designed to harness the strengths of both approaches while mitigating their limitations. PIPCDR incorporates a positive instance proximity loss and a cluster dispersion regularizer. The positive instance proximity loss ensures alignment between augmented views of instances and their sampled neighbors, enhancing within-cluster compactness by selecting genuinely positive pairs within the embedding space. Meanwhile, the cluster dispersion regularizer maximizes inter-cluster distances while minimizing within-cluster compactness, promoting uniformity in the learned representations. PIPCDR excels in producing well-separated clusters, generating uniform representations, avoiding class collision issues, and enhancing within-cluster compactness. We extensively validate the effectiveness of PIPCDR within an end-to-end Majorize-Minimization framework, demonstrating its competitive performance on moderate-scale clustering benchmark datasets and establishing new state-of-theart results on large-scale datasets. ⓘ Kumar, Abhishek; Lee, Dong-Gyu ⓘ Sejong Univ, Dept Comp Sci & Engn, Neungdong Ro, Seoul 05006, South Korea; Kyungpook Natl Univ, Dept Artificial Intelligence, Daehak Ro, Daegu 41566, South Korea ⓘ ; Kumar, Abhishek/ABA-5251-2021 ⓘ 57206266703; 57169003900 ⓘ dglee@knu.ac.kr; ⓘ INFORMATION SCIENCES ⓘ INFORM SCIENCES ⓘ 0020-0255 1872-6291 686 SCIE COMPUTER SCIENCE, INFORMATION SYSTEMS ⓘ 2024 6.8 7.9 0 2025-05-07 ⓘ 0 1 Deep clustering; Self-supervised learning; Representation learning; Contrastive learning; Class collision ⓘ ⓘ Class collision; Contrastive learning; Deep clustering; Representation learning; Self-supervised learning ⓘ Adversarial machine learning; Federated learning; Self-supervised learning; Supervised learning; Class collision; Clustering approach; Clusterings; Deep clustering; End to end; Positive instances; Proximity loss; Regularizer; Representation learning; Within clusters; Contrastive Learning ⓘ English 2025 2025-01 10.1016/j.ins.2024.121277 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Event-triggered sliding mode control for interval type-2 fuzzy interconnected systems under Markov-model-based hybrid cyberattacks ⓘ This paper studies the event-triggered sliding mode control problem for interval type-2 fuzzy interconnected systems under hybrid cyberattacks modeled by Markov processes. Under the framework of an interval type-2 fuzzy model, the nonlinear relationship in the interconnected system is modeled and analyzed, and a fuzzy sliding mode controller is designed which can effectively resist hybrid cyberattacks. To rationally utilize limited channel resources, a decentralized event-triggered mechanism is used to reduce unnecessary information transmission. By constructing a Lyapunov function, some criteria are deduced to ensure that the closed-loop system is stochastically passive and the reachability of the designed sliding area is guaranteed. Finally, a four-area networked interconnected system is used to verify the effectiveness of the decentralized fuzzy sliding mode control strategy. © 2025 Elsevier Inc. ⓘ Wang, Xiulin; Li, Feng; Lee, Sangmoon; Shen, Hao ⓘ School of Electrical and Information Engineering, Anhui University of Technology, Maanshan, 243032, China; School of Electrical and Information Engineering, Anhui University of Technology, Maanshan, 243032, China, School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, South Korea; School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, South Korea; School of Electrical and Information Engineering, Anhui University of Technology, Maanshan, 243032, China ⓘ ⓘ 59417311300; 56589219600; 59510733500; 35230989600 ⓘ fengli4131@gmail.com; moony@knu.ac.kr; ⓘ Information Sciences ⓘ INFORM SCIENCES ⓘ 0020-0255 1872-6291 719 SCIE COMPUTER SCIENCE, INFORMATION SYSTEMS ⓘ 2024 6.8 7.9 ⓘ 0 ⓘ ⓘ Dynamic event-triggered mechanism; Hybrid cyberattacks; Interval type-2 fuzzy systems; Markov jump interconnected systems; Sliding mode control ⓘ Closed loop systems; Fuzzy models; Fuzzy systems; Large scale systems; Lyapunov functions; Markov processes; Robustness (control systems); Cyber-attacks; Dynamic event-triggered mechanism; Dynamic events; Event-triggered; Hybrid cyberattack; Interval type-2 fuzzy; Interval type-2 fuzzy system; Markov jump interconnected system; Markov jumps; Sliding-mode control; Type-2 fuzzy systems; Sliding mode control ⓘ English Final 2025 10.1016/j.ins.2025.122467 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Interval type-2 fuzzy PID controllers with interval of confidence and various types of footprints of uncertainty ⓘ This study introduces the notion of interval of confidence (IoC) for the modeling of fuzzy controllers and presents three novel mathematical models of interval type-2 fuzzy proportional- integral-derivative (IT2FPID) controllers by utilizing the concept of IoC and various types of footprints of uncertainty (FoUs) having parallelogram, bottom-wide triangle, and top-wide triangle shapes. The properties and computational aspects of the proposed controllers are analyzed mainly in terms of IoCs and FoUs. All the developed controllers with various types of FoUs are plant-model-free nonlinear controllers with variable gains and structures. It is proved that more generalized models of IT2FPID controllers can be attained by replacing the fuzzy singletons with IoCs. The suitability of introducing IoC in IT2FPID controllers is verified by showing that IoC does not play any role in the mathematical modeling of type-1 (T1) fuzzy PID controllers. To demonstrate the effectiveness of the proposed controllers, extensive simulation studies and numerical and hardware experiments are conducted. The simulation and experimental results affirm the proposed controllers' superiority over conventional and fuzzy PID ones, opening up new possibilities for improved performance in real-world control applications. ⓘ Sain, Debdoot; Praharaj, Manoranjan; Mohan, B. M.; Yang, Jung-Min ⓘ Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Indian Inst Technol Kharagpur, Dept Elect Engn, Kharagpur 721302, India ⓘ ; Sain, Debdoot/AAD-4709-2021; Bosukonda, Murali/KLE-0140-2024 ⓘ 57192083193; 57224405027; 7006334785; 57208450551 ⓘ saindebdoot@knu.ac.kr; praharaj@iitkgp.ac.in; mohan@ee.iitkgp.ac.in; jmyang@ee.knu.ac.kr; ⓘ INFORMATION SCIENCES ⓘ INFORM SCIENCES ⓘ 0020-0255 1872-6291 699 SCIE COMPUTER SCIENCE, INFORMATION SYSTEMS ⓘ 2024 6.8 7.9 3.02 2025-05-07 ⓘ 1 1 Mamdani fuzzy controller; IT2 fuzzy PID controller; Mathematical modeling; Interval of confidence; Footprint of uncertainty; Experimental validation ⓘ INTEGRATING PROCESSES; STABILITY ANALYSIS; ORDER; PERFORMANCE; DESIGN; IMPLEMENTATION; DERIVATION; SYSTEM ⓘ Experimental validation; Footprint of uncertainty; Interval of confidence; IT2 fuzzy PID controller; Mamdani fuzzy controller; Mathematical modeling ⓘ Choquet integral; Fuzzy control; Three term control systems; Two term control systems; Uncertainty analysis; Experimental validations; Footprint of uncertainties; Fuzzy controllers; Fuzzy PID controller; Interval of confidence; Interval type-2 fuzzy; IT2 fuzzy PID controller; Mamdani; Mamdani fuzzy controller; Mathematical modeling; Fuzzy models ⓘ English 2025 2025-05 10.1016/j.ins.2024.121795 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Signal-based classification of cementitious materials using machine learning techniques ⓘ The material properties of cementitious mixtures are critically influenced by their mixing ratios and curing periods. However, existing nondestructive testing methods based on elastic waves primarily provide information on stiffness characteristics, without offering insights into mix design or curing duration. This study proposes a machine learning (ML)-based approach for estimating the mixing ratios and curing periods of cementitious materials using time-series shear wave signals obtained from bender elements. Three ML models-one-dimensional convolutional neural network, InceptionTime, and Random Convolutional Kernel Transform-are applied to classify 16 cementitious mixtures. The signal patterns from the bender elements are recorded for four cementitious mixtures with different mixing ratios over four curing periods ranging from 1 to 28 days. Using data from a shear wave measurement system, the models estimate 16 unique classes of mixtures. Model performance is evaluated across training, validation, and test sets. All models generalize well to unseen data, achieving an accuracy greater than 0.98. The InceptionTime model notably achieves the highest accuracy at 0.992. In addition, the confusion matrix analysis confirms that the models produce very few misclassifications, indicating strong predictive performance. Overall, the one-dimensional convolutional neural network offers the best balance between accuracy and computational efficiency. These findings suggest that machine learning techniques for time series analysis can estimate the mixing ratios and curing periods of cementitious materials from signal patterns effectively. ⓘ Aregbesola, Samuel Olamide; Lee, Dongsoo; Byun, Yong-Hoon ⓘ Univ Florida, Dept Soil Water & Ecosyst Sci, Gainesville, FL 32611 USA; Univ Illinois Urbana & Champaign, Dept Civil & Environm Engn, Urbana, IL 61801 USA; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Byun, Yong-Hoon/JKI-8441-2023; Aregbesola, Samuel/LXV-8805-2024 ⓘ 58631316600; 59926763100; 42761048000 ⓘ yhbyun@knu.ac.kr; ⓘ CASE STUDIES IN CONSTRUCTION MATERIALS ⓘ CASE STUD CONSTR MAT ⓘ 2214-5095 22 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 6.6 7.9 0 2025-06-11 ⓘ 0 0 Classification; Convolutional neural network; Elastic wave; Machine learning; Signal ⓘ STIFFNESS CHARACTERISTICS; SHEAR-WAVE; STRENGTH ⓘ Classification; Convolutional neural network; Elastic wave; Machine learning; Signal ⓘ Binary mixtures; Bender elements; Cementitious; Cementitious materials; Convolutional neural network; Curing periods; Machine learning techniques; Machine-learning; Mixing ratios; One-dimensional; Signal; Elastic waves ⓘ English 2025 2025-07 10.1016/j.cscm.2025.e04860 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ The effect of blockability affordance on confrontation against cyberbullying on social networking sites: theoretical and methodological implications ⓘ PurposeSocial networking sites (SNS) have become popular mediums for individuals to interact with others. However, despite the positive impact of SNS on people's lives, cyberbullying has become prevalent. Due to this prevalence, substantial research has examined cyberbullying from the perspectives of perpetrators, bystanders, and victims, but little is known about SNS users' confrontations with cyberbullying. The objectives of this study are to examine confrontation as a victim's coping response, the effect of blockability affordance on victims' protection motivation, the impact of a victim's experiences with cyberbullying perpetration, and social desirability (SD) bias in the context of cyberbullying victimization.Design/methodology/approachThis study examines the effect of blockability affordance on SNS users' protection motivation. It also investigates the relationships among perceived threat, perceived coping efficacy, and use of confrontation. Furthermore, this investigation analyzes the effect of SNS users' experiences as perpetrators on their decision to confront cyberbullies. Finally, this study assesses and controls SD bias in SNS users' confrontation behavior. To test the research model, we used an online vignette study to collect 314 data points.FindingsBlockability affordance, perceived threat, perceived coping efficacy, and cyberbullying perpetration experiences are essential factors in explaining use of confrontation. This study also finds SD bias in the context of cyberbullying victimization.Originality/valueThis is one of the first studies in information systems research to empirically examine the effect of blockability affordance in the context of cyberbullying. ⓘ Kwak, Dong-Heon; Kim, Dongyeon; Lee, Saerom; Kang, Martin; Park, Soomin; Knapp, Deborah ⓘ Kent State Univ, Ambassador Crawford Coll Business & Entrepreneurs, Kent, OH USA; Kyungpook Natl Univ, Sch Business Adm, Daegu, South Korea; Loyola Marymount Univ, Coll Business Adm, Los Angeles, CA USA; Howard Univ, Sch Business, Washington, DC USA ⓘ ⓘ 57188818439; 59124543500; 59510718200; 57201980944; 57990772300; 7102604826 ⓘ saeromlee@knu.ac.kr; ⓘ INTERNET RESEARCH ⓘ INTERNET RES ⓘ 1066-2243 35 2 SSCI;SCIE BUSINESS;TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS ⓘ 2024 6.8 7.9 0 2025-05-07 ⓘ 0 0 Cyberbullying; Blockability affordance; Confrontation; Coping; Protection motivation theory; Prior experience ⓘ SEXUAL-HARASSMENT; SECURITY BEHAVIORS; COPING STRATEGIES; MENTAL-HEALTH; INFORMATION; VICTIMS; VICTIMIZATION; RESPONSES; GENDER; SCHOOL ⓘ Blockability affordance; Confrontation; Coping; Cyberbullying; Prior experience; Protection motivation theory ⓘ ⓘ English 2025 2025-03-18 10.1108/intr-05-2023-0422 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Thermomechanical properties of high-volume fly ash concrete for application in mass concrete ⓘ This study aims to examine the thermomechanical properties of high-volume fly ash (HVFA) concrete for mass concrete applications. To achieve this, compressive strength, elastic modulus, adiabatic temperature rise, and thermal conductivity tests were conducted by varying the fly ash substitution ratio and Blaine fineness, along with the addition of limestone powder. Furthermore, 1200 x 1200 x 1200 mm cube-shaped mock-up members were fabricated to measure the temperature history and analyze the thermal crack index. Finite element analysis (FEA) was also performed to assess the temperature distribution and thermal stresses in HVFA concrete. The experimental results demonstrated that HVFA concrete achieves long-term compressive strength development due to the pozzolanic reaction of fly ash-a process that can be accelerated by utilizing more finely ground fly ash. Additionally, the compressive strength of HVFA concrete exhibited greater sensitivity to variations in curing temperature compared to that of normal concrete. The maximum adiabatic temperature rise of HVFA concrete decreased to 22.3 % of that of normal concrete, with this reduction becoming more significant as the fly ash substitution rate increased. The high fineness of fly ash and the addition of limestone powder increased the adiabatic temperature rise by 31.9 % and 14.9 %, respectively, compared to HVFA concrete with the same substitution rate. The mock-up test revealed that the temperature at the center of the HVFA concrete specimen decreased by 32.9 % relative to that of normal concrete and that resistance to thermal cracking improved with higher fly ash substitution rates. Further FEA validated the experimental results, demonstrating that fly ash substitution helps mitigate the risk of cracking by reducing thermal stresses in mass concrete structures. ⓘ Oh, Sangwoo; Oh, Gyujong; Hong, Geuntae; Choi, Young-Cheol; Choi, Seongcheol ⓘ Chung Ang Univ, Dept Civil & Environm Engn, 84 Heukseok Ro, Seoul 06974, South Korea; Kyungpook Natl Univ, Dept Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Gachon Univ, Dept Civil & Environm Engn, 1342 Seongnam Daero, Seongnam 13120, Gyeonggido, South Korea ⓘ ⓘ 57223979407; 59743302200; 57193714827; 57281478200; 35221260900 ⓘ dnsndn@cau.ac.kr; ohkj2999@cau.ac.kr; gthong@knu.ac.kr; zerofe@gachon.ac.kr; schoi@cau.ac.kr; ⓘ CASE STUDIES IN CONSTRUCTION MATERIALS ⓘ CASE STUD CONSTR MAT ⓘ 2214-5095 22 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 6.6 7.9 0 2025-05-07 ⓘ 0 0 High-volume fly ash (HVFA); Adiabatic temperature rise; Mock-up test; Thermal crack index; Compressive strength; Curing temperature ⓘ COMPRESSIVE STRENGTH; THERMAL-CONDUCTIVITY; LIMESTONE POWDER; SILICA FUME; CEMENT; HYDRATION; AGGREGATE; CRACKING; HEAT; SLAG ⓘ Adiabatic temperature rise; Compressive strength; Curing temperature; High-volume fly ash (HVFA); Mock-up test; Thermal crack index ⓘ Compressive strength; Concrete buildings; Concrete testing; Concretes; Cracks; Creep; Fracture mechanics; Mockups; Temperature distribution; Thermal conductivity; Thermal stress; Adiabatic temperature rise; Crack indices; Curing temperature; High volume fly ash; High volume fly ash concrete; High-volume fly ash; High-volume fly ash concretes; Mockup test; Thermal crack index; Thermal cracks; Limestone ⓘ English 2025 2025-07 10.1016/j.cscm.2025.e04681 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Review ⓘ Advances in spectroscopic detection of traumatic brain injury biomarkers: Potential for diagnostic applications ⓘ Traumatic brain injury (TBI) is an increasing worldwide health problem, driving the need for highly accurate and reliable diagnostic tools for early detection in clinical applications. Due to the high cost and time-consuming nature of traditional imaging techniques, spectroscopic methodologies are emerging as an excellent alternative for rapid promising diagnosis via direct measurements of TBI-specific biomarker concentrations in the biofluids of TBI patients. This review will first introduce the predominantly investigated TBI biomarkers, including S100 calcium-binding protein B, ubiquitin C-terminal hydrolase L1, glial fibrillary acidic protein, neuron-specific enolase, neurofilament light polypeptide, and Tau, highlighting their importance and feasibility in diagnostic applications. The recent development of conventional spectroscopic detection methodologies, classified into labeling and label-free approaches, will then be highlighted for determining TBI biomarker levels found in biofluidic samples as a valuable assessment platform. These methodologies include colorimetry, fluorescence, chemiluminescence, surface plasmon resonance, Raman spectroscopy, electrochemical impedance spectroscopy, and mass spectrometry. This review will finally explore the latest advancements in nanomaterial-integrated spectroscopic detection methods for TBI biomarkers in biofluids, emphasizing their unique advantages and limitations in point-of-care diagnostic platforms and discussing future perspectives. © 2025 Taylor & Francis Group, LLC. ⓘ Son, Yejin; Jeong, Mungyeong; Lim, Jong Min; Venkatesh, Krishnan; Karuppiah, Chelladurai; Lee, Hye Jin ⓘ Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea; Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu-city, 41566, South Korea ⓘ ⓘ 59728320900; 59727747200; 59728712500; 57217832861; 55910716400; 56569175200 ⓘ kcdurai.rmd@gmail.com; ⓘ Applied Spectroscopy Reviews ⓘ APPL SPECTROSC REV ⓘ 0570-4928 1520-569X SCIE INSTRUMENTS & INSTRUMENTATION;SPECTROSCOPY ⓘ 2024 5.4 8.0 0 2025-05-07 ⓘ 0 ⓘ ⓘ biomarkers; diagnostic applications; nanomaterials; Spectroscopic techniques; traumatic brain injury ⓘ Biomarkers; Brain mapping; Hydrolases; Neurons; Raman spectroscopy; Surface plasmon resonance; Biofluids; Clinical application; Diagnostic applications; Diagnostics tools; High costs; Highly accurate; Problem driving; Spectroscopic detection; Spectroscopic technique; Traumatic Brain Injuries; Electrochemical impedance spectroscopy ⓘ English Article in press 2025 10.1080/05704928.2025.2483396 ⓘ 바로가기 바로가기 바로가기
○ Review ⓘ Recent advances in single-cell metabolomics using mass spectrometry: emerging challenges and future perspectives ⓘ Cellular heterogeneity plays a pivotal role in organismal physiology, influencing developmental processes, disease progression, and therapeutic responses. Single-cell metabolomics (SCM) emerges as a powerful tool to interrogate the metabolic diversity of individual cells, offering insights into cellular phenotypes beyond genomics, or transcriptomics. Recent advancements in microfluidics, automation, and image analysis have enabled minimally invasive single-cell isolation, while development of innovative mass spectrometry (MS)-based techniques has transformed metabolite detection with their high sensitivity, broad detection range, and molecular specificity. Despite challenges such as the non-amplifiable nature of metabolites and their dynamic concentration ranges like proteins, significant progress has been made in MS platforms, ionization methods, and data analysis strategies. This review highlights the latest innovations in SCM, including nano-electrospray ionization, laser desorption/ionization, and other MS techniques, alongside applications in diverse cell types such as cancer cells, plant cells, neurons, stem cells, and immune cells. Integrating SCM with orthogonal single-cell omics holds promise for systems-level understanding, with potential applications in translational and clinical research. Addressing current limitations in throughput, sensitivity, and data processing will be essential to fully unlock the potential of SCM in answering fundamental and applied biological questions. © 2025 Taylor & Francis Group, LLC. ⓘ Alam, Rafiqul; Lee, Jung-Hyun; Shin, Doyun; Choi, Il-Kyu; Kim, Sunghwan; Lim, Heejin; Kim, Min-Sik ⓘ Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea; Department of Chemistry, Kyungpook National University, Daegu, South Korea; Center for Scientific Instrumentation, Korea Basic Science Institute (KBSI), Daejeon, South Korea; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea, New Biology Research Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea, Center for Cell Fate Reprogramming and Control, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea ⓘ ⓘ 57219723992; 58068197100; 59697186200; 59525944000; 57203772967; 57200994073; 59525976200 ⓘ mkim@dgist.ac.kr; hjlim0111@kbsi.re.kr; ⓘ Applied Spectroscopy Reviews ⓘ APPL SPECTROSC REV ⓘ 0570-4928 1520-569X SCIE INSTRUMENTS & INSTRUMENTATION;SPECTROSCOPY ⓘ 2024 5.4 8.0 0 2025-05-07 ⓘ 0 ⓘ ⓘ cellular heterogeneity; imaging mass spectrometry; mass spectrometry; Single-cell metabolomics ⓘ ⓘ English Article in press 2025 10.1080/05704928.2025.2483996 ⓘ 바로가기 바로가기 바로가기
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