2021 연구성과 (34 / 281)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Rice Cultivars Under Salt Stress Show Differential Expression of Genes Related to the Regulation of Na⁺/K⁺ Balance | Soil salinity is a major problem in agriculture because high accumulation of Na+ ions in plants causes toxicity that can result in yield reduction. Na+/K+ homeostasis is known to be important for salt tolerance in plants. Na+/K+ homeostasis in rice (Oryza sativa L.) involves nine high-affinity K+ transporter (HKT) encoding Na+-K+ symporter, five OsNHX Na+/H+ antiporters, and OsSOS1 Na+/K+ antiporter genes. In the present study, we investigated various molecular and physiological processes to evaluate germination rate, growth pattern, ion content, and expression of OsHKT, OsNHX, and OsSOS1genes related to Na+/K+ homeostasis in different rice genotypes under salt stress. We found a significant increase in the germination percentage, plant vigor, Na+/K+ ratio, and gene expression of the OsHKT family in both the roots and shoots of the Nagdong cultivar and salt-tolerant cultivar Pokkali. In the roots of Cheongcheong and IR28 cultivars, Na+ ion concentrations were found to be higher than K+ ion concentrations. Similarly, high expression levels of OsHKT1, OsHKT3, and OsHKT6 were observed in Cheongcheong, whereas expression levels of OsHKT9 was high in IR28. The expression patterns of OsNHX and OsSOS1 and regulation of other micronutrients differed in the roots and shoots regions of rice and were generally increased by salt stress. The OsNHX family was also expressed at high levels in the roots of Nagdong and in the roots and shoots of Pokkali; in contrast, comparatively low expression levels were observed in the roots and shoots of Cheongcheong and IR28 (with the exception of high OsNHX1 expression in the roots of IR28). Furthermore, the OsSOS1 gene was highly expressed in the roots of Nagdong and shoots of Cheongcheong. We also observed that salt stress decreases chlorophyll content in IR28 and Pokkali but not in Cheongcheong and Nagdong. This study suggests that under salt stress, cultivar Nagdong has more salt-tolerance than cultivar Cheongcheong. | Farooq, Muhammad; Park, Jae-Ryoung; Jang, Yoon-Hee; Kim, Eun-Gyeong; Kim, Kyung-Min | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Plant Biosci, Sch Appl Biosci, Daegu, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014 | 57215544380; 57211205505; 57219901992; 57221496070; 34868260300 | kkm@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 12 | SCIE | PLANT SCIENCES | 2021 | 6.627 | 8.2 | 3.13 | 2025-07-30 | 37 | 47 | Na+/K+ homeostasis; cultivar Pokkali; cultivar IR28; high-affinity K+ transporter family; sodium; proton exchangers family; salt overly sensitive | NUTRIENT COMPOSITION; OSMOTIC ADJUSTMENT; HKT TRANSPORTERS; SODIUM-TRANSPORT; TOLERANCE; SALINITY; GROWTH; POTASSIUM; HOMEOSTASIS; TOMATO | cultivar IR28; cultivar Pokkali; high-affinity K<sup>+</sup> transporter family; Na<sup>+</sup>/K<sup>+</sup>homeostasis; salt overly sensitive; sodium/proton exchangers family | English | 2021 | 2021-08-13 | 10.3389/fpls.2021.680131 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Stacked DeBERT: All attention in incomplete data for text classification | In this paper, we propose Stacked DeBERT, short for Stacked Denoising Bidirectional Encoder Representations from Transformers. This novel model improves robustness in incomplete data, when compared to existing systems, by designing a novel encoding scheme in BERT, a powerful language representation model solely based on attention mechanisms. Incomplete data in natural language processing refer to text with missing or incorrect words, and its presence can hinder the performance of current models that were not implemented to withstand such noises, but must still perform well even under duress. This is due to the fact that current approaches are built for and trained with clean and complete data, and thus are not able to extract features that can adequately represent incomplete data. Our proposed approach consists of obtaining intermediate input representations by applying an embedding layer to the input tokens followed by vanilla transformers. These intermediate features are given as input to novel denoising transformers which are responsible for obtaining richer input representations. The proposed approach takes advantage of stacks of multilayer perceptrons for the reconstruction of missing words' embeddings by extracting more abstract and meaningful hidden feature vectors, and bidirectional transformers for improved embedding representation. We consider two datasets for training and evaluation: the Chatbot Natural Language Understanding Evaluation Corpus and Kaggle's Twitter Sentiment Corpus. Our model shows improved F1-scores and better robustness in informal/incorrect texts present in tweets and in texts with Speech-to-Text error in the sentiment and intent classification tasks.(1) (C) 2020 Elsevier Ltd. All rights reserved. | Sergio, Gwenaelle Cunha; Lee, Minho | Sch Elect & Elect Engn, Daejeon, South Korea; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | 57188756097; 57191730119 | mholee@knu.ac.kr; | NEURAL NETWORKS | NEURAL NETWORKS | 0893-6080 | 1879-2782 | 136 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES | 2021 | 9.657 | 8.2 | 1.19 | 2025-07-30 | 18 | 22 | Incomplete text classification; Incomplete data; Speech-to-Text error; BERT; Transformers; Denoising | BERT; Denoising; Incomplete data; Incomplete text classification; Speech-to-Text error; Transformers | Databases, Factual; Humans; Language; Natural Language Processing; Neural Networks, Computer; Speech; Classification (of information); Embeddings; Linguistics; Multilayer neural networks; Natural language processing systems; Signal encoding; Attention mechanisms; Classification tasks; Existing systems; Intermediate inputs; NAtural language processing; Natural language understanding; Representation model; Text classification; article; attention; controlled study; embedding; human; human experiment; multilayer perceptron; natural language processing; noise; nonhuman; speech; Vanilla; classification; factual database; language; natural language processing; speech; Text processing | English | 2021 | 2021-04 | 10.1016/j.neunet.2020.12.018 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Superconducting joints using multifilament MgB2 wires for MRI application | We present superconducting joints using 36 filaments magnesium diboride (MgB2) wires in continuation joint orientation and their characterisation results for the first time. One of the joints demonstrated the critical temperature (offset) of 34.4 K and the critical current (I-c) of 38.5 A at 10 K in self-field. Unconventional I-c behaviour of the joint was observed at 20 K in self-field when the I-c was measured in a high to a low field due to the effect of field trapping in the MgB2 bulk within the joint. Elemental mapping at the interface between the MgB2 bulk and the filament revealed oxidation, which was attributed to being responsible for reducing the I-c of the joint. This work will notably contribute towards MgB2 superconducting joint technology development for magnetic resonance imaging (MRI) application. (C) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | Patel, Dipak; Matsumoto, Akiyoshi; Kumakura, Hiroaki; Maeda, Minoru; Kim, Sun-Hu; Liang, Hao; Yamauchi, Yusuke; Choi, Seyong; Kim, Jung Ho; Hossain, Md Shahriar A. | Univ Queensland, Sch Mech & Min Engn, St Lucia, Qld 4067, Australia; Natl Inst Mat Sci NIMS, 1-2-1 Sengen, Tsukuba, Ibaraki 3050047, Japan; Kangwon Natl Univ, Dept Elect Engn, Kangwon 25913, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea; Univ Queensland, Australian Inst Bioengn & Nanotechnol AIBN, St Lucia, Qld 4072, Australia; Natl Inst Mat Sci NIMS, JST ERATO Yamauchi Mat Space Tecton Project, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan; Natl Inst Mat Sci NIMS, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan; Univ Wollongong, Inst Superconducting & Elect Mat, Australian Inst Innovat Mat, North Wollongong, NSW 2500, Australia | Maeda, Minoru/AAB-5589-2020; Patel, Dipak/G-8293-2014; Kim, Jung Ho/D-4097-2014; Yamauchi, Yusuke/D-2780-2015; KUMAKURA, Hiroaki/H-2526-2011; Choi, Seyong/AAB-5572-2020; MATSUMOTO, Akiyoshi/H-2765-2011 | 26040989200; 7403108130; 35459081100; 35426900700; 57226432372; 57226431821; 58118749400; 7408122787; 35215131600; 55050121600 | dipak.patel@uq.edu.au;matsumoto.akiyoshi@nims.go.jp; | SCRIPTA MATERIALIA | SCRIPTA MATER | 1359-6462 | 1872-8456 | 204 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2021 | 6.302 | 8.2 | 1.23 | 2025-07-30 | 19 | 19 | Magnesium diboride; MgB2 superconducting joint; Multifilament MgB2 wire; Critical current; MRI application | Critical current; Magnesium diboride; MgB<sub>2</sub> superconducting joint; MRI application; Multifilament MgB<sub>2</sub> wire | Magnetic resonance imaging; Critical temperatures; Elemental mapping; Field trapping; Joint orientations; Magnesium diborides; Multi-filament; Superconducting joints; Technology development; Magnesium compounds | English | 2021 | 2021-11 | 10.1016/j.scriptamat.2021.114156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Role of Nitric Oxide-Induced ATILL6 in Growth and Disease Resistance in Arabidopsis thaliana | Nitric oxide (NO) is a signaling molecule that regulates various processes, including plant growth and development, immunity, and environmental interactions. Using high throughput RNA-seq data, we explored the role of the NO-induced ATILL6 gene in plant growth and defense using functional genomics. The atill6 mutant and wild-types were challenged with either oxidative (H2O2, MV) or nitro-oxidative (CySNO, GSNO) stress conditions, and the phenotypic results showed that ATILL6 gene differentially regulates cotyledon development frequency (CDF) as well as the root and shoot lengths of the plants. To investigate whether ATILL6 plays a role in plant basal or resistance (R)-gene-mediated defense, the plants were challenged with either virulent or avirulent strains of Pseudomonas syringae pathovar tomato (Pst) DC3000. The atill6 line showed a susceptible phenotype, higher pathogen growth, and highly reduced transcript accumulation of PR1 and PR2 genes. These results suggested that ATILL6 positively regulates plant basal defense. Furthermore, after the inoculation of atill6 with avirulent Pst (DC3000), the expressions of the PR1 and PR2 genes decreased, suggesting a positive role in R-gene-mediated resistance in protecting the plant from further spread of disease. We also investigated the role of ATILL6 in systemic acquired resistance (SAR), and the results showed that ATILL6 positively regulates SAR, as the mutant line atill6 has significantly (p <= 0.05) lower transcript accumulation of PR, G3DPH, and AZI genes. Overall, these results indicate that the NO-induced ATILL6 gene differentially regulates plant growth and positively regulates plant basal defense, R-gene-mediated resistance, and SAR. | Khan, Murtaza; Al Azawi, Tiba Nazar Ibrahim; Pande, Anjali; Mun, Bong-Gyu; Lee, Da-Sol; Hussain, Adil; Lee, Byung-Hyun; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Minist Agr, State Co Agr Supplies, Baghdad, Iraq; Abdul Wali Khan Univ Mardan, Dept Entomol, Mardan, Pakistan; Gyeongsang Natl Univ, Plant Mol Biol & Biotechnol Res Ctr PMBBRC, Inst Agr & Life Sci IALS, Div Appl Life Sci,BK21 Program, Jinju, South Korea | Lee, Byung-Hyun/AAD-7977-2022; Mun, BongGyu/GYD-6010-2022; Hussain, Dr. Adil/K-6016-2018; Pande, Anjali/ABH-2333-2021 | 57207990116; 57224980187; 57222624154; 57147241300; 57222624235; 41961162600; 35429311300; 8245123600 | bwyun@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 12 | SCIE | PLANT SCIENCES | 2021 | 6.627 | 8.2 | 2.48 | 2025-07-30 | 25 | 35 | Arabidopsis thaliana; growth under control; oxidative stress; nitro-oxidative stress; plant defense | S-NITROSYLATION; NO NEWS; ACID; MUTANTS; PLANTS; STRESS; ACTIVATION; RESPONSES; GENES; LIGHT | Arabidopsis thaliana; growth under control; nitro-oxidative stress; oxidative stress; plant defense | English | 2021 | 2021-07-02 | 10.3389/fpls.2021.685156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Vesicular glutamate transporter-immunopositive axons that coexpress neuropeptides in the rat and human dental pulp | Aim To examine the type of vesicular glutamate transporter (VGLUT)-immunopositive (+) axons that coexpress neuropeptides in the rat and human dental pulp, which may help understand peripheral mechanism of pulpal inflammatory pain in rats and humans. Methodology The trigeminal ganglia (TG) and the dental pulp of the maxillary molar teeth from three male Sprague-Dawley rats weighing 300-330 g and dental pulps of three healthy human (male) maxillary premolar teeth from three 16 to 28-year-old patients extracted for orthodontic treatment were used. The type of VGLUT + axons that coexpress substance P (SP)- and/or calcitonin gene-related peptide (CGRP) and parvalbumin in the rat TG and in the axons of the rat and the human dental pulp was examined by double fluorescence immunohistochemistry and quantitative analysis. Results were analyzed using one-way anova and the Kruskal-Wallis test. Results SP and CGRP were expressed in many human VGLUT1 + pulpal axons but not in the rat VGLUT1 + TG neurons and pulpal axons (P < 0.05). SP and CGRP were expressed in a considerable number of human VGLUT2 + pulpal axons and also in many rat TG neurons and pulpal axons. The fraction of VGLUT1 + axons expressing parvalbumin was about three times higher in the rat than in the human dental pulp (P < 0.05). Conclusions These findings suggest that the types of VGLUT + axons, which release neuropeptides, may be different between the rat and the human dental pulp, raising a possibility that peripheral mechanism of pulpal inflammatory pain may be different between rats and humans. | Cho, Y. S.; Ko, H. G.; Han, H. M.; Park, S. K.; Moozhayil, S. J.; Choi, S. Y.; Bae, Y. C. | Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, 2177 Dalgubeol Daero, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea | 23979595700; 14522654800; 57204187581; 37099111300; 56524663600; 57202918688; 56377838800 | ycbae@knu.ac.kr; | INTERNATIONAL ENDODONTIC JOURNAL | INT ENDOD J | 0143-2885 | 1365-2591 | 54 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 5.165 | 8.2 | 0.43 | 2025-07-30 | 3 | 3 | dental pulp; glutamate; inflammatory pain; neuropeptide; vesicular glutamate transporter | GENE-RELATED PEPTIDE; SUBSTANCE-P; SPINAL-CORD; PAIN; EXPRESSION; NEURONS; ROOT; INFLAMMATION; NOCICEPTORS; AFFERENTS | dental pulp; glutamate; inflammatory pain; neuropeptide; vesicular glutamate transporter | Animals; Axons; Dental Pulp; Humans; Neuropeptides; Rats; Rats, Sprague-Dawley; Vesicular Glutamate Transport Proteins; neuropeptide; vesicular glutamate transporter; animal; axon; human; rat; Sprague Dawley rat; tooth pulp | English | 2021 | 2021-03 | 10.1111/iej.13427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Visual question answering based on local-scene-aware referring expression generation | Visual question answering requires a deep understanding of both images and natural language. However, most methods mainly focus on visual concept; such as the relationships between various objects. The limited use of object categories combined with their relationships or simple question embedding is insufficient for representing complex scenes and explaining decisions. To address this limitation, we propose the use of text expressions generated for images, because such expressions have few structural constraints and can provide richer descriptions of images. The generated expressions can be incorporated with visual features and question embedding to obtain the question-relevant answer. A joint-embedding multi-head attention network is also proposed to model three different information modalities with co-attention. We quantitatively and qualitatively evaluated the proposed method on the VQA v2 dataset and compared it with state-of-the-art methods in terms of answer prediction. The quality of the generated expressions was also evaluated on the RefCOCO, RefCOCO+, and RefCOCOg datasets. Experimental results demonstrate the effectiveness of the proposed method and reveal that it outperformed all of the competing methods in terms of both quantitative and qualitative results. (C) 2021 Elsevier Ltd. All rights reserved. | Kim, Jung-Jun; Lee, Dong-Gyu; Wu, Jialin; Jung, Hong-Gyu; Lee, Seong-Whan | Korea Univ, Dept Brain & Cognit Engn, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Univ Texas Austin, Dept Comp Sci, Austin, TX 78712 USA; Korea Univ, Dept Artificial Intelligence, Seoul 02841, South Korea | wu, jialin/JPY-4408-2023 | 57222114263; 57169003900; 57204291571; 55560691100; 7601390519 | sw.lee@korea.ac.kr; | NEURAL NETWORKS | NEURAL NETWORKS | 0893-6080 | 1879-2782 | 139 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES | 2021 | 9.657 | 8.2 | 1.02 | 2025-07-30 | 22 | 23 | Visual question answering; Joint-embedding multi-head attention; Referring expression generation | RECOGNITION; LANGUAGE | Joint-embedding multi-head attention; Referring expression generation; Visual question answering | Natural Language Processing; Neural Networks, Computer; Pattern Recognition, Automated; Natural language processing systems; Quality control; Visual languages; Joint-embedding multi-head attention; Natural languages; Object categories; Question Answering; Question-embedding; Referring expression generation; Referring expressions; Simple++; Visual concept; Visual question answering; article; attention network; embedding; human; human experiment; prediction; quantitative analysis; automated pattern recognition; natural language processing; procedures; Embeddings | English | 2021 | 2021-07 | 10.1016/j.neunet.2021.02.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium induced colitis in mice (vol 44, pg 833, 2020) | Saba, Evelyn; Lee, Yuan Yee; Kim, Minki; Hyun, Sun-Hee; Park, Chae-Kyu; Son, Eunjung; Kim, Dong-Seon; Kim, Sung-Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Vet Physiol Lab, Daegu, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon, South Korea; Korea Inst Oriental Med, KM Convergence Res Div, Daejeon, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Vet Biomed Sci, Rawalpindi, Pakistan | Saba, Evelyn/JLN-1878-2023; Rhee, Man/O-5705-2016; Yuan Yee, Lee/ABH-8956-2022 | 56721112000; 57203798815; 57199747297; 57225302366; 55885553100; 57195251310; 56947571300; 55156746000; 57211035357 | sdkim@dirams.re.kr;rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 2 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 0 | 2025-07-30 | 0 | 0 | erratum | English | 2021 | 2021-03 | 10.1016/j.jgr.2021.02.008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Amoeba Genome Reveals Dominant Host Contribution to Plastid Endosymbiosis | Eukaryotic photosynthetic organelles, plastids, are the powerhouses of many aquatic and terrestrial ecosystems. The canonical plastid in algae and plants originated >1 Ga and therefore offers limited insights into the initial stages of organelle evolution. To address this issue, we focus here on the photosynthetic amoeba Paulinella micropora strain KR01 (hereafter, KR01) that underwent a more recent (similar to 124 Ma) primary endosymbiosis, resulting in a photosynthetic organelle termed the chromatophore. Analysis of genomic and transcriptomic data resulted in a high-quality draft assembly of size 707 Mb and 32,361 predicted gene models. A total of 291 chromatophore-targeted proteins were predicted in silico, 208 of which comprise the ancestral organelle proteome in photosynthetic Paulinella species with functions, among others, in nucleotide metabolism and oxidative stress response. Gene coexpression analysis identified networks containing known high light stress response genes as well as a variety of genes of unknown function ("dark" genes). We characterized diurnally rhythmic genes in this species and found that over 49% are dark. It was recently hypothesized that large double-stranded DNA viruses may have driven gene transfer to the nucleus in Paulinella and facilitated endosymbiosis. Our analyses do not support this idea, but rather suggest that these viruses in the KR01 and closely related P. micropora MYN1 genomes resulted from a more recent invasion. | Lhee, Duckhyun; Lee, JunMo; Ettahi, Khaoula; Cho, Chung Hyun; Ha, Ji-San; Chan, Ya-Fan; Zelzion, Udi; Stephens, Timothy G.; Price, Dana C.; Gabr, Arwa; Nowack, Eva C. M.; Bhattacharya, Debashish; Yoon, Hwan Su | Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea; Kyungpook Natl Univ, Dept Oceanog, Daegu, South Korea; Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08854 USA; Rutgers State Univ, Ctr Vector Biol, Dept Entomol, New Brunswick, NJ USA; Rutgers State Univ, Microbiol & Mol Genet Grad Program, New Brunswick, NJ USA; Heinrich Heine Univ, Inst Mikrobielle Zellbiol, Dusseldorf, Germany | Cho, Chung Hyun/AAM-1233-2020; Stephens, Timothy/C-7967-2017; Yoon, Hwan Su/A-2974-2013; Nowack, Eva/F-7879-2018 | 57193491958; 57217851052; 57221838250; 57091111200; 57195549047; 57219821426; 57204216308; 57189507577; 37112890400; 57140209500; 9334443800; 7201931909; 35239094800 | d.bhattacharya@rutgers.edu;hsyoon2011@skku.edu; | MOLECULAR BIOLOGY AND EVOLUTION | MOL BIOL EVOL | 0737-4038 | 1537-1719 | 38 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;EVOLUTIONARY BIOLOGY;GENETICS & HEREDITY | 2021 | 8.8 | 8.3 | 2 | 2025-07-30 | 25 | 26 | chromatophore; gene coexpression analysis; Paulinella; photosynthetic amoeba; primary endosymbiosis | RNA-SEQ DATA; CHROMATOPHORE GENOME; PHOTOSYSTEM-II; HIGH-LIGHT; GLUTATHIONE-REDUCTASE; ENRICHMENT ANALYSIS; GENE-EXPRESSION; SEQUENCE; EVOLUTION; PROTEIN | chromatophore; gene coexpression analysis; Paulinella; photosynthetic amoeba; primary endosymbiosis | Amoeba; Chromatophores; Genome, Plastid; Genome, Protozoan; Symbiosis; Transcriptome; transcriptome; amoeba (life cycle stage); Article; cell nucleus; cell organelle; chromatophore; computer model; double-stranded DNA virus; endosymbiosis; gene expression; gene transfer; genomics; host; light stress; nonhuman; nucleotide metabolism; oxidative stress; Paulinella micropora; photosynthesis; plastid genome; predictive value; transcriptomics; amoeba (life cycle stage); chromatophore; genetics; genome; metabolism; symbiosis; virology | English | 2021 | 2021-02 | 10.1093/molbev/msaa206 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Effect of Korean Red Ginseng on metabolic syndrome | Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Yoon, Sang Jun; Kim, Seul Ki; Lee, Na Young; Choi, Ye Rin; Kim, Hyeong Seob; Gupta, Haripriya; Youn, Gi Soo; Sung, Hotaik; Shin, Min Jea; Suk, Ki Tae | Hallym Univ, Inst Liver & Digest Dis, Chunchon, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Kim, Soo-Yeon/ADR-9663-2022; Gupta, Haripriya/ADF-9486-2022; Kim, Yong Won/AAA-2134-2022; Lee, Nayoung/LXB-5417-2024 | 57214226795; 57220602372; 57214223390; 57220602316; 57220605029; 57211533706; 54894334000; 55240452500; 35485651200; 57226393680 | ktsuk@hallym.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 9.15 | 2025-07-30 | 52 | 50 | Panax ginseng; Metabolic syndrome; Insulin resistance; Non-alcoholic fatty liver disease | FATTY-LIVER-DISEASE; IMPROVES INSULIN SENSITIVITY; ACTIVATED PROTEIN-KINASE; PANAX-GINSENG; MATRIX METALLOPROTEINASES; MOLECULAR-MECHANISMS; ADIPOSE-TISSUE; HEPATOCELLULAR-CARCINOMA; 20(S)-GINSENOSIDE RG(3); DIABETES-MELLITUS | Insulin resistance; Metabolic syndrome; Non-alcoholic fatty liver disease; Panax ginseng | ginseng extract; cardiovascular disease; diabetes mellitus; dyslipidemia; ginseng; human; insulin resistance; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; obesity; priority journal; Short Survey; therapy effect; traditional medicine | English | 2021 | 2021-05 | 10.1016/j.jgr.2020.11.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes | Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+], transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (GEF) on the gene expression of six LPARSs remain unknown. We examined changes in the gene expression of six LPA receptors in the mouse whole brain, heart, lungs, liver, kidneys, spleen, small intestine, colon, and testis after long-term oral GEF administration. Methods: C57BL/6 mice were divided into two groups: control vehicle and GEF (100 mg/kg, p.o.). After 21-day saline or GEF treatment, total RNA was extracted from nine mouse organs. Quantitative-real-time PCR (qRT-PCR) and western blot were performed to quantify changes in the gene and protein expression of the six LPARSs, respectively. Results: qRT-PCR analysis before GEF treatment revealed that the LPA6 RS was predominant in all organs except the small intestine. The LPA2 RS was most abundant in the small intestine. Long-term GEF administration differentially regulated the six LPARSs. Upon GEF treatment, the LPA6 RS significantly increased in the liver, small intestine, colon, and testis but decreased in the whole brain, heart, lungs, and kidneys. Western blot analysis of the LPA6 RS confirmed the differential effects of GEF on LPA6 receptor protein levels in the whole brain, liver, small intestine, and testis. Conclusion: The LPA6 receptor was predominantly expressed in all nine organs examined; long-term oral GEF administration differentially regulated LPA3, LPA4, and LPA6 receptors in the whole brain, heart, lungs, liver, kidneys, small intestine, and testis. (C) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Lee, Rami; Lee, Byung-Hwan; Choi, Sun-Hye; Cho, Yeon-Jin; Cho, Han-Sung; Kim, Hyoung-Chun; Rhim, Hyewhon; Cho, Ik-Hyun; Rhee, Man Hee; Nah, Seung-Yeol | Konkuk Univ, Coll Vet Med, Ginsentol Res Lab, Seoul 05029, South Korea; Konkuk Univ, Coll Vet Med, Dept Physiol, Seoul 05029, South Korea; Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon, South Korea; Korea Inst Sci & Technol, Ctr Neurosci, Seoul, South Korea; Kyung Hee Univ, Grad Sch, Dept Convergence Med Sci, Dept Sci Korean Med, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu, South Korea | Rhee, Man/O-5705-2016; Rhim, Hyewhon/IUM-8410-2023; Cho, Ik-Hyun/A-9348-2014; Cho, Young Hye/AEJ-4099-2022; Lee, Rami/ISS-1321-2023 | 57034602100; 35432179400; 22133433200; 57215495037; 57222196783; 36065569300; 7006154214; 7102561903; 57211035357; 7005224178 | synah@konkuk.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 5 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 0.32 | 2025-07-30 | 5 | 4 | Differential LPA6 receptor subtype; regulation; Ginseng; Gintonin; Mouse organs; Six LPA receptor subtypes | ACID; GINSENG; GROWTH; PROTECTS; LIPIDS | Differential LPA6 receptor subtype regulation; Ginseng; Gintonin; Mouse organs; Six LPA receptor subtypes | beta actin; complementary DNA; genomic DNA; gintonin enriched fraction; herbaceous agent; lysophosphatidic acid; lysophosphatidic acid receptor; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor 2; lysophosphatidic acid receptor 3; lysophosphatidic acid receptor 4; lysophosphatidic acid receptor 5; lysophosphatidic acid receptor 6; receptor protein; receptor subtype; RNA; saponin; sodium chloride; unclassified drug; unclassified drug; animal experiment; animal tissue; Article; brain tissue; colon tissue; controlled study; drug effect; fractionation; gene expression; ginseng; heart tissue; kidney tissue; liver tissue; long term care; lung parenchyma; male; mouse; nonhuman; protein expression; real time polymerase chain reaction; regulatory mechanism; RNA extraction; small intestine; spleen tissue; testis; Western blotting | English | 2021 | 2021-09 | 10.1016/j.jgr.2021.02.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium | Background: Invasive infections due to foodborne pathogens, including Salmonella enterica serovar Typhimurium, are prevalent and life-threatening. This study aimed to evaluate the effects of ginsenoside Rg3 (Rg3) on the adhesion, invasion, and intracellular survival of S. Typhimurium. Methods: The impacts of Rg3 on bacterial growth and host cell viability were determined using the time kill and the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assays, respectively. Gentamicin assay and confocal microscopic examination were undertaken to determine the effects of Rg3 on the adhesive and invasive abilities of S. Typhimurium to Caco-2 and RAW264.7 cells. Quantitative reverse transcription polymerase chain reaction was performed to assess the expression of genes correlated with the adhesion, invasion, and virulence of S. Typhimurium. Results: Subinhibitory concentrations of Rg3 significantly reduced (p < 0.05) the adhesion, invasion, and intracellular survival of S. Typhimurium. Rg3 considerably reduced (p < 0.05) the bacterial motility as well as the release of nitrite from infected macrophages in a concentration-dependent manner. The expression of genes related to the adhesion, invasion, quorum sensing, and virulence of S. Typhimurium including cheY, hilA, OmpD, PrgK, rsgE, SdiA, and SipB was significantly reduced after Rg3 treatment. Besides, the compound downregulated rac-1 and Cdc-42 that are essential for actin remodeling and membrane ruffling, thereby facilitating Salmonella entry into host cells. This report is the first to describe the effects of Rg3 on "trigger" entry mechanism and intracellular survival S. Typhimurium. Conclusion: Rg3 could be considered as a supplement agent to prevent S. Typhimurium infection. (C) 2019 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | Mechesso, Abraham F.; Quah, Yixian; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, 80 Daehakro, Daegu 41566, South Korea | Park, Seung-Chun/AAV-3388-2021; Mechesso, Abraham/AAU-7158-2021; Yixian, Quah/ABE-7629-2021 | 56811692500; 55886933200; 7501832396 | parksch@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 1 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 1.81 | 2025-07-30 | 21 | 20 | adhesion; ginsenoside Rg3; invasion; S. Typhimurium; survival | III SECRETION; PATHOGENICITY ISLAND-1; VIRULENCE FACTORS; ESCHERICHIA-COLI; NITRIC-OXIDE; HOST-CELLS; RESISTANCE; CHEMOTAXIS; EXPRESSION; PROTEIN | adhesion; ginsenoside Rg3; invasion; S. Typhimurium; survival | 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide; actin; bacterial protein; CheY protein; dimethyl sulfoxide; gentamicin; ginsenoside Rg 3; hilA protein; marbofloxacin; nitrite; outer membrane protein; outer membrane protein D; prgK protein; protein Cdc42; Rac1 protein; rsgE protein; sdiA protein; sipB protein; unclassified drug; animal cell; antibacterial activity; antibiotic sensitivity; Article; bacterial gene; bacterial growth; bacterial strain; bacterial virulence; bactericidal activity; Caco-2 cell line; cell adhesion; cell invasion; cell motility; cell survival; cell viability; concentration (parameter); confocal microscopy; controlled study; cytotoxicity; gene expression; host cell; human; human cell; intestine epithelium cell; macrophage; minimum inhibitory concentration; MTT assay; nonhuman; priority journal; quantitative analysis; quorum sensing; RAW 264.7 cell line; real time reverse transcription polymerase chain reaction; receptor down regulation; Salmonella enterica serovar Typhimurium; time | English | 2021 | 2021-01 | 10.1016/j.jgr.2019.09.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ginsenoside Rk1 suppresses platelet mediated thrombus formation by downregulation of granule release and αIIbβ3 activation | Background and objective: Synthetic ginsenoside compounds G-Rp (1,3, and 4) and natural ginsenosides in Panax ginseng 20(S)-Rg3, Rg6, F4 and Ro have inhibitory actions on human platelets. However, the inhibitory mechanism of ginsenoside Rk1 (G-Rk1) is still unclear thus, we initiated investigation of the anti-platelet mechanism by G-Rk1 from Panax ginseng. Methodology: Our study focused to investigate the action of G-Rk1 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin alpha(IIb)beta(3) using flow cytometry, intracellular calcium mobilization, fibronectin adhesion, dense granule secretion, and thromboxane B2 secretion. Thrombin-induced clot retraction was also observed in human platelets. Key Results: Collagen, thrombin, and U46619-stimulated human platelet aggregation were dosedependently inhibited by G-Rk1, while it demonstrated a more effective suppression on collagenstimulated platelet aggregation using human platelets. Moreover, G-Rk1 suppressed collagen-induced elevation of Ca2+ release from endoplasmic reticulum, granule release, and alpha(IIb)beta(3) activity without any cytotoxicity. Conclusions and implications: These results indicate that G-Rk1 possess strong anti-platelet effect, proposing a new drug candidate for treatment and prevention of platelet-mediated thrombosis in cardiovascular disease. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Shin, Jung-Hae; Kwon, Hyuk-Woo; Irfan, Muhammad; Rhee, Man Hee; Lee, Dong-Ha | Catholic Kwandong Univ, Dept Biomed Lab Sci, Kangnung, South Korea; Far East Univ, Dept Biomed Lab Sci, Eumseong, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu, South Korea; Univ Illinois, Dept Oral Bio, Chicago, IL USA; Namseoul Univ, Dept Biomed Lab Sci, Cheonan, South Korea; Namseoul Univ, Mol Diagnost Res Inst, Cheonan, South Korea | Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021 | 56244056800; 55200547400; 35069404400; 57211035357; 57208891222 | dhlee@nsu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 2.24 | 2025-07-30 | 21 | 22 | Anti-platelet; Ginsenoside-Rk1; Integrin alpha(IIb)beta(3); Thrombosis; Clot retraction | INHIBITION; DEFICIENCY; REVEALS; CELLS; MICE | Anti-platelet; Clot retraction; Ginsenoside-Rk1; Integrin α<sub>IIb</sub>β<sub>3</sub>; Thrombosis | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetylsalicylic acid; alpha2bbeta3 integrin; collagen; cytosolic phospholipase A2; fibrinogen; fibronectin; ginsenoside; ginsenoside rk1; integrin; mitogen activated protein kinase 14; protein kinase B; thrombin; thromboxane B2; unclassified drug; vasodilator stimulated phosphoprotein; animal experiment; animal model; antiplatelet activity; Article; blood clot retraction; blood clotting; calcium cell level; calcium mobilization; cell granule; controlled study; cytometry; cytotoxicity; endoplasmic reticulum; ginseng; human; human cell; lung embolism; male; mouse; nonhuman; normal human; protein dephosphorylation; protein protein interaction; thrombocyte; thrombocyte aggregation; thrombocyte aggregation inhibition | English | 2021 | 2021-07 | 10.1016/j.jgr.2020.11.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Gintonin influences the morphology and motility of adult brain neurons via LPA receptors | Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor. Recently, we reported that systemic administration of gintonin increases blood-brain barrier (BBB) permeability via the paracellular pathway and its binding to brain neurons. However, little is known about the influences of gintonin on in vivo neuron morphology and migration in the brain. Materials and methods: We examined the effects of gintonin on in vitro migration and morphology using primary hippocampal neural precursor cells (hNPC) and in vivo effects of gintonin on adult brain neurons using real time microscopic analysis and immunohistochemical analysis to observe the morphological and locational changes induced by gintonin treatment. Results: We found that treating hNPCs with gintonin induced morphological changes with a cell rounding following cell aggregation and return to individual neurons with time relapses. However, the in vitro effects of gintonin on hNPCs were blocked by the LPA1/3 receptor antagonist, Ki16425, and Rho kinase inhibitor, Y27632. We also examined the in vivo effects of gintonin on the morphological changes and migration of neurons in adult mouse brains using anti-NeuN and -neurofilament H antibodies. We found that acute intravenous administration of gintonin induced morphological and migrational changes in brain neurons. Gintonin induced some migrations of neurons with shortened neurofilament H in the cortex. The in vivo effects of gintonin were also blocked by Ki16425. Conclusion: The present report raises the possibility that gintonin could enter the brain and exert its influences on the migration and morphology of adult mouse brain neurons and possibly explains the therapeutic effects of neurological diseases behind the gintonin administration. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Kim, Do-Geun; Kim, Hyeon-Joong; Choi, Sun-Hye; Nam, Sung Min; Kim, Hyoung-Chun; Rhim, Hyewhon; Cho, Ik-Hyun; Rhee, Man Hee; Nah, Seung-Yeol | Korea Brain Res Inst, Dementia Res Grp, Cheomdanro 61, Daegu 41062, South Korea; Konkuk Univ, Coll Vet Med, Ginsentol Res Lab, Seoul 05029, South Korea; Konkuk Univ, Coll Vet Med, Dept Physiol, Seoul 05029, South Korea; Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon, South Korea; Korea Inst Sci & Technol, Ctr Neurosci, Seoul, South Korea; Kyung Hee Univ, Coll Korean Med, Brain Korea 21 Plus Program, Dept Convergence Med Sci, Seoul, South Korea; Kyung Hee Univ, Coll Korean Med, Inst Korean Med, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu, South Korea; Wonkwang Univ, Sch Med, Dept Anat, Iksan, South Korea; Wonkwang Univ, Inst Environm Sci, Iksan, South Korea | ; Cho, Young Hye/AEJ-4099-2022; Rhim, Hyewhon/IUM-8410-2023; KIM, Hyeon-Joong/C-4448-2011; Rhee, Man/O-5705-2016; Cho, Ik-Hyun/A-9348-2014 | 55797863700; 40661631600; 22133433200; 37112929400; 36065569300; 7006154214; 7102561903; 57211035357; 7005224178 | kimvet0911@kbri.re.kr;synah@konkuk.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 0.21 | 2025-07-30 | 3 | 3 | Gintonin; Morphology and migration; LPA receptors; Adult brain neuron | LYSOPHOSPHATIDIC ACID RECEPTOR; MICE; LIGAND | Adult brain neuron; Gintonin; LPA receptors; Morphology and migration | 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide; epidermal growth factor; fibroblast growth factor; ginseng extract; gintonin; ketamine; ki 16425; linoleic acid; lysophosphatidic acid; lysophosphatidic acid receptor; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor 3; lysophosphatidylcholine; neurofilament h; neuron specific nuclear protein; oleic acid; palmitic acid; phosphatidic acid; Rho guanine nucleotide binding protein; Rho kinase; Rho kinase inhibitor; unclassified drug; xylazine; adult; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; brain; brain cortex; brain nerve cell; brain region; cell aggregation; cell migration; cell motility; cell structure; controlled study; drug effect; ginseng; hippocampal neural precursor cell; hippocampus; immunohistochemistry; in vitro study; in vivo study; male; microscopy; mouse; nerve cell; neural stem cell; nonhuman; priority journal | English | 2021 | 2021-05 | 10.1016/j.jgr.2020.06.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism | Background: Korean ginseng (Panax ginseng Meyer) contains a variety of ginsenosides that can be metabolized to a biologically active substance, compound K. Previous research showed that compound K could be enriched in the red ginseng extract (RGE) after hydrolysis by pectinase. The current study investigated whether the enzymatically hydrolyzed red ginseng extract (HRGE) containing a notable level of compound K has cognitive improving and neuroprotective effects. Methods: A scopolamine-induced hypomnesic mouse model was subjected to behavioral tasks, such as the Y-maze, passive avoidance, and the Morris water maze tests. After sacrificing the mice, the brains were collected, histologically examined (hematoxylin and eosin staining), and the expressions of antioxidant proteins analyzed by western blot. Results: Behavioral assessment indicated that the oral administration of HRGE at a dosage of 300 mg/kg body weight reversed scopolamine-induced learning and memory deficits. Histological examination demonstrated that the hippocampal damage observed in scopolamine-treated mouse brains was reduced by HRGE administration. In addition, HRGE administration increased the expression of nuclear-factor-E2-related factor 2 and its downstream antioxidant enzymes NAD(P)H:quinone oxidoreductase and heme oxygenase-1 in hippocampal tissue homogenates. An in vitro assay using HT22 mouse hippocampal neuronal cells demonstrated that HRGE treatment attenuated glutamate-induced cytotoxicity by decreasing the intracellular levels of reactive oxygen species. Conclusion: These findings suggest that HRGE administration can effectively alleviate hippocampusmediated cognitive impairment, possibly through cytoprotective mechanisms, preventing oxidativestress-induced neuronal cell death via the upregulation of phase 2 antioxidant molecules. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Ju, Sunghee; Seo, Ji Yeon; Lee, Seung Kwon; Oh, Jisun; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol BIC21 Plus, Daegu, South Korea; Ilhwa Co Ltd, Ginseng Biotech Res Team, Guri, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Korea Inst Sci & Technol, Brain Sci Inst, Ctr Funct Connect & Ctr Neurosci, Seoul 02792, South Korea | 57188996528; 55830284200; 57075993500; 56311554100; 37106950100 | j.oh@knu.ac.kr;vision@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 45 | 1 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 5.735 | 8.3 | 3.09 | 2025-07-30 | 27 | 30 | Cognition; Korean Red Ginseng; Learning and memory; Neuroprotection; Pectinase-mediated hydrolysis | BRAIN OXIDATIVE STRESS; COMPOUND K; COGNITIVE IMPAIRMENT; NRF2; METABOLITE; GINSENOSIDES; ACTIVATION; INHIBITION; RECEPTOR; DEMENTIA | Cognition; Korean Red Ginseng; Learning and memory; Neuroprotection; Pectinase-mediated hydrolysis | antioxidant; compound k; ginseng extract; ginsenoside 3r; ginsenoside 3s; ginsenoside f2; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rc; ginsenoside Rd; ginsenoside Rh 2; heme oxygenase 1; neuroprotective agent; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone); scopolamine; tacrine; transcription factor Nrf2; unclassified drug; ABTS radical scavenging assay; animal experiment; animal model; animal tissue; Article; cell protection; cell viability; comparative study; controlled study; cytotoxicity; drug mechanism; enzymatic hydrolysis; ginseng; hippocampal tissue; HT22 cell line; in vitro study; latent period; learning disorder; male; Morris water maze test; mouse; mouse model; neuroapoptosis; neuropathology; neuroprotection; nonhuman; oxidative stress; passive avoidance; pathogenesis; priority journal; protein expression; quantitative analysis; scopolamine induced learning disorder; scopolamine-induced amnesia; South Korea; ultra performance liquid chromatography; upregulation; Western blotting; Y-maze test | English | 2021 | 2021-01 | 10.1016/j.jgr.2019.12.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Performance of the plasma Aβ42/Aβ40 ratio, measured with a novel HPLC-MS/MS method, as a biomarker of amyloid PET status in a DPUK-KOREAN cohort | Background: We assessed the feasibility of plasma A beta 42/A beta 40 determined using a novel liquid chromatography-mass spectrometry method (LC-MS) as a useful biomarker of PET status in a Korean cohort from the DPUK Study. Methods: A total of 580 participants belonging to six groups, Alzheimer's disease dementia (ADD, n = 134), amnestic mild cognitive impairment (aMCI, n = 212), old controls (OC, n = 149), young controls (YC, n = 15), subcortical vascular cognitive impairment (SVCI, n = 58), and cerebral amyloid angiopathy (CAA, n = 12), were included in this study. Plasma A beta 40 and A beta 42 were quantitated using a new antibody-free, LC-MS, which drastically reduced the sample preparation time and cost. We performed receiver operating characteristic (ROC) analysis to develop the cutoff of A beta 42/A beta 40 and investigated its performance predicting centiloid-based PET positivity (PET+). Results: Plasma A beta 42/A beta 40 were lower for PET+ individuals in ADD, aMCI, OC, and SVCI (p < 0.001), but not in CAA (p = 0.133). In the group of YC, OC, aMCI, and ADD groups, plasma A beta 42/A beta 40 predicted PET+ with an area under the ROC curve (AUC) of 0.814 at a cutoff of 0.2576. When adding age, APOE4, and diagnosis, the AUC significantly improved to 0.912. Conclusion: Plasma A beta 42/A beta 40, as measured by this novel LC-MS method, showed good discriminating performance based on PET positivity. | Jang, Hyemin; Kim, Ji Sun; Lee, Hye Joo; Kim, Chi-Hun; Na, Duk L.; Kim, Hee Jin; Allue, Jose Antonio; Sarasa, Leticia; Castillo, Sergio; Pesini, Pedro; Gallacher, John; Seo, Sang Won | Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Samsung Med Ctr, Neurosci Ctr, 81 Irwon Ro, Seoul 06351, South Korea; Alzheimers Dis Convergence Res Ctr, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England; Samsung Med Ctr, Stem Cell & Regenerat Med Inst, 81 Irwon Ro, Seoul 06351, South Korea; Dept Hlth Sci & Technol, Seoul, South Korea; Araclon Biotech Grifols, Via Hispanidad 21, Zaragoza 50009, Spain; Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Dept Intelligent Precis Healthcare Convergence, Sch Med, Seoul, South Korea | Na, Duk/C-9598-2011; Lee, Hyejoo/HZI-7153-2023; Allue Creus, Jose/F-4206-2016; Kim, Hee/AAU-6368-2021 | 56651581700; 57201935930; 57202931045; 56984274000; 7103210298; 57225132536; 59229673000; 36562742600; 57892795400; 6603105366; 7005198349; 16305669100 | sw72.seo@samsung.com; | ALZHEIMERS RESEARCH & THERAPY | ALZHEIMERS RES THER | 1758-9193 | 13 | 1 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2021 | 8.831 | 8.3 | 1.68 | 2025-07-30 | 23 | 26 | Biomarker; Alzheimer's disease; Amyloid; Plasma; A beta 42/A beta 40; Liquid chromatography-mass spectrometry | CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; CSF BIOMARKER; BETA LEVELS; DIAGNOSIS; ANGIOPATHY; COGNITION; DEMENTIA; BURDEN; EFFLUX | Alzheimer’s disease; Amyloid; Aβ42/Aβ40; Biomarker; Liquid chromatography-mass spectrometry; Plasma | Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Chromatography, High Pressure Liquid; Humans; Peptide Fragments; Republic of Korea; Tandem Mass Spectrometry; amyloid beta protein[1-40]; amyloid beta protein[1-42]; apolipoprotein E4; amyloid beta protein; amyloid beta-protein (1-42); biological marker; peptide fragment; adult; age distribution; aged; Alzheimer disease; Article; cognitive defect; cohort analysis; controlled study; differential diagnosis; feasibility study; female; high performance liquid chromatography; human; Korean (people); liquid chromatography-mass spectrometry; major clinical study; male; mild cognitive impairment; positron emission tomography; protein blood level; reference value; subcortical vascular cognitive impairment; validation process; vascular amyloidosis; Alzheimer disease; diagnostic imaging; high performance liquid chromatography; South Korea; tandem mass spectrometry | English | 2021 | 2021-10-22 | 10.1186/s13195-021-00911-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: