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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Bakuchicin attenuates atopic skin inflammation ⓘ Psoralea corylifolia is a medicinal herb that provides advantageous pharmacological effects against vitiligo and skin rash. Former studies have shown that bakuchicin, a furanocoumarin compound from the fruits of P. corylifolia, has therapeutic effects against inflammation, and infection. This study aimed to define the pharmacological effects of bakuchicin on inflammatory responses and lichenification, the major symptoms of atopic dermatitis (AD). To induce AD-like skin inflammation, we exposed the ears of female BALB/c mice to 2, 4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae (house dust mite) extract (DFE) for 4 weeks. Intragastric administration of bakuchicin attenuated the symptoms of AD-like skin inflammation, as evident by reductions in ear thickness, erythema, and keratosis. Bakuchicin also reversed increases in auricular epidermal and dermal layer thicknesses, and attenuated eosinophil and mast cell infiltration in AD-induced mice. It also suppressed T(h)2 gene expression as well as that of pro-inflammatory cytokines and chemokines, such as interleukin (IL)-4, IL-13, IL-31, IL-1 beta, IL-6, CXCL-1, and CCL-17 in the ear tissue. The levels of total and DFE-specific immunoglobulin (Ig)E, and IgG2a in the mice sera were reduced by the bakuchicin. To investigate the effect of bakuchicin on keratinocytes, experiments were performed using HaCaT cells, the representative cell type used in skin disease studies. Tumor necrosis factor-a and interferon-gamma were used to activate keratinocytes. Bakuchicin suppressed T(h)2 gene expression and that of pro-inflammatory cytokines and chemokines; it also suppressed STAT-1 phosphorylation and the nuclear translocation of NF-kappa B in activated keratinocytes. These results suggest that bakuchicin attenuated AD symptoms, thus suggesting it as a potential therapeutic agent for the treatment of AD. ⓘ Lim, Jae-Sung; Kim, Jun Young; Lee, Soyoung; Choi, Jin Kyeong; Kim, Eun-Nam; Choi, Young-Ae; Jang, Yong Hyun; Jeong, Gil-Saeng; Kim, Sang-Hyun ⓘ Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; Jeonbuk Natl Univ, Dept Immunol, Med Sch, Jeonju, South Korea; Keimyung Univ, Coll Pharm, Daegu, South Korea ⓘ Lim, Jae-Sung/HLV-7060-2023 ⓘ 57217360234; 35310922800; 8537269200; 50261279600; 57201655294; 7404777420; 57016046400; 57204396456; 57210450420 ⓘ yhjang@knu.ac.kr;gsjeong@kmu.ac.kr;shkim72@knu.ac.kr; ⓘ BIOMEDICINE & PHARMACOTHERAPY ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 129 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2020 6.53 8.9 0.7 2025-06-25 ⓘ 12 12 Atopic dermatitis; Keratinocytes; Eosinophils; Bakuchicin ⓘ EOSINOPHILS; DERMATITIS; ACTIVATION; CYTOKINES; CORTICOSTEROIDS; MECHANISMS; EXTRACT; MITES; CELLS; SEEDS ⓘ Atopic dermatitis; Bakuchicin; Eosinophils; Keratinocytes ⓘ Animals; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Arthropod Proteins; Cell Line; Chronic Disease; Cytokines; Dermatitis, Atopic; Dermatologic Agents; Dinitrochlorobenzene; Disease Models, Animal; Female; Heterocyclic Compounds, 3-Ring; Humans; Immunoglobulin E; Immunoglobulin G; Keratinocytes; Mice, Inbred BALB C; NF-kappa B; Phosphorylation; Skin; STAT1 Transcription Factor; 1 chloro 2,4 dinitrobenzene; antiinflammatory agent; bakuchicin; CXCL1 chemokine; dexamethasone; furocoumarin derivative; gamma interferon; house dust mite allergen extract; immunoglobulin E; immunoglobulin G2a; interleukin 13; interleukin 1beta; interleukin 31; interleukin 4; interleukin 6; thymus and activation regulated chemokine; tumor necrosis factor; unclassified drug; antiinflammatory agent; arthropod protein; bakuchicin; cytokine; dermatological agent; fused heterocyclic rings; house dust allergen; immunoglobulin E; immunoglobulin enhancer binding protein; immunoglobulin G; STAT1 protein; STAT1 protein, human; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; atopic dermatitis; cell activation; controlled study; cytokine release; ear thickness; ear tissue; enzyme linked immunosorbent assay; eosinophil; erythema; female; gene expression; HaCat cell line; high performance liquid chromatography; histopathology; immunoglobulin blood level; keratinocyte; mast cell; mouse; nonhuman; priority journal; proton nuclear magnetic resonance; real time polymerase chain reaction; symptom; Th2 cell; Western blotting; animal; atopic dermatitis; Bagg albino mouse; blood; cell line; chronic disease; disease model; drug effect; human; metabolism; pathology; phosphorylation; skin ⓘ English 2020 2020-09 10.1016/j.biopha.2020.110466 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Decursin promotes HIF-1α proteasomal degradation and immune responses in hypoxic tumour microenvironment ⓘ Background: Hypoxia and HIF-1 alpha are important regulators of tumour growth and angiogenesis and could be attractive targets for cancer therapeutics. Decursin is an active compound extracted from the roots of Angelica gigas and has been shown to have potent anti-cancer and anti-angiogenic activities. However, whether decursin regulates HIF-1 alpha activity and immune responses under hypoxic conditions is not yet understood. Purpose: The aim of this study was to identify whether decursin exhibits anti-cancer activity by targeting HIF-1 alpha. Study design: We investigated whether decursin regulates HIF-1 alpha protein stability and increases its degradation. In addition, we determined if decursin increases immune responses in tumour microenvironment to identify its hypoxia-associated anti-cancer activities. Materials and methods: We performed the hypoxia-responsive element promoter-reporter assay, Western blot analysis, immune-fluorescence assay, semi-quantitative RT-PCR and ELISA for VEGF secretion, CCK-8 assay for cell proliferation, TUNEL assay for apoptosis and invasion assay in A549 human lung cancer or HCT116 human colon cancer cells. In vivo Lewis lung carcinoma (LLC) allograft mouse model was used to check tumour growth and immune responses in tumour microenvironment by immunohistochemistry analysis. Results: We observed that decursin inhibited HIF-1 activation under hypoxia by down-regulating the protein level of its subunit HIF-1 alpha. It increased oxygen-dependant hydroxylation and ubiquitination of HIF-1 alpha to promote HIF-1 alpha degradation. Decursin also decreased mRNA expression of HIF-1 alpha target genes. Decursin suppressed cancer cell proliferation, induced apoptosis and inhibited cancer cell invasion under hypoxia in cancer cells. In the allograft mouse tumour model, decursin reduced the hypoxic area and HIF-1 alpha and PD-L1 expression. Infiltrating T cells (CD3 +), helper T cells (CD4 +) and cytotoxic (CD8 +) T cells were accumulated, but regulatory T cells (Foxp3) and myeloid-derived suppressor cell-mediated immune suppressors (Arg1) were attenuated by decursin. Conclusion: Our results suggest that decursin is a novel HIF-1 alpha inhibitor that functions by promoting its proteasomal degradation and that it also helps improve T cell activation in tumour microenvironment; these findings provide new explanations about its anti-cancer and anti-angiogenic activity mechanisms. ⓘ Ge, Yun; Yoon, Soo-Hyun; Jang, Hyeonha; Jeong, Ji-Hak; Lee, You-Mie ⓘ Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multiom Creat Drug Res Team, Daegu, South Korea; Kyunpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Dept Mol Pathophysiol, Vasc Organ Interact Res Ctr,VOICE MRC, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Lee, Kyung-Soo/C-9016-2011 ⓘ 57217852719; 34968837000; 57218761651; 55913671500; 8230508600 ⓘ lym@knu.ac.kr; ⓘ PHYTOMEDICINE ⓘ PHYTOMEDICINE ⓘ 0944-7113 1618-095X 78 SCIE CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES ⓘ 2020 5.34 8.9 2.53 2025-06-25 ⓘ 42 45 Hypoxia; HIF-1 alpha; Decursin; Proteasomal degradation; Anti-cancer; Immune response ⓘ CHEMOKINE RECEPTOR CXCR4; INDUCIBLE FACTORS; CANCER; ANGIOGENESIS; SUPPRESSION; EXPRESSION; INHIBITOR; MECHANISM; APOPTOSIS; BLOCKADE ⓘ Anti-cancer; Decursin; HIF-1α; Hypoxia; Immune response; Proteasomal degradation ⓘ A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; B7-H1 Antigen; Benzopyrans; Butyrates; CD8-Positive T-Lymphocytes; Cell Proliferation; Down-Regulation; Gene Expression Regulation; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Inbred C57BL; Tumor Hypoxia; Tumor Microenvironment; Ubiquitination; Xenograft Model Antitumor Assays; antineoplastic agent; arginase 1; decursin; hypoxia inducible factor 1alpha; messenger RNA; programmed death 1 ligand 1; proteasome; tanespimycin; unclassified drug; antineoplastic agent; benzopyran derivative; butyric acid derivative; CD274 protein, human; decursin; HIF1A protein, human; hypoxia inducible factor 1alpha; programmed death 1 ligand 1; A-549 cell line; animal experiment; animal model; animal tissue; antiangiogenic activity; antineoplastic activity; apoptosis; Article; cancer inhibition; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; down regulation; drug hydroxylation; drug mechanism; embryo; gene expression; HCT 116 cell line; human; human cell; immune response; immunohistochemistry; in vivo study; lung carcinoma; mouse; myeloid-derived suppressor cell; nonhuman; priority journal; protein degradation; protein stability; protein targeting; T lymphocyte activation; tumor hypoxia; tumor microenvironment; ubiquitination; animal; C57BL mouse; cell proliferation; drug effect; drug screening; gene expression regulation; immunology; metabolism; tumor hypoxia ⓘ English 2020 2020-11 10.1016/j.phymed.2020.153318 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Development and Usability Evaluation of a Facebook-Based Intervention Program for Childhood Cancer Patients: Mixed Methods Study ⓘ Background: Childhood cancers previously considered to be incurable now have 5-year survival rates up to 84%. Nevertheless, these patients remain at risk of morbidity and mortality from therapy-related complications. Thus, patient education and self-management strategies for promoting a healthy lifestyle are of tantamount importance for improving short- and long-term health outcomes. A Facebook-based "Healthy Teens for Soaam" (a Korean term for childhood cancers) program was developed to help improve knowledge and self-management practices of teens with cancer related to their disease and treatment. Objective: The two-fold purpose of this usability study was (1) to describe the process of developing an 8-week Facebook-based intervention program for teens with cancer, and (2) to evaluate its usability to refine the program. Methods: Multiple phases and methods were employed to develop and evaluate the usability of the program. Study phases included: (1) needs assessment through focus group interviews and qualitative content analysis, (2) development of module content, (3) expert review and feedback on module content, (4) Facebook-based program development, (5) usability evaluation by heuristic evaluation, (6) usability evaluation by targeted end-user testing, and (7) modification and final version of the program. Usability of the final version was confirmed through feedback loops of these phases. Results: Based on 6 focus group discussion sessions, it was determined that teens with cancer were interested in seeing stories of successful childhood cancer cases and self-management after discharge, and preferred multimedia content over text. Therefore, each Facebook module was redesigned to include multimedia materials such as relevant video clips tailored for teens. Usability assessed by heuristic evaluation and user testing revealed several critical usability issues, which were then revised. Potential end users tested the final program and perceived it to be usable and useful for teens with cancer. Conclusions: To our knowledge, "Healthy Teens for Soaam" is the first Facebook-based intervention program for teens with cancer. We actively worked with current childhood cancer patients and survivors to develop and improve this program, achieved good usability, and met the expressed needs and preferences of target end users. This 8-week Facebook-based educational program for teens with cancer, developed as the first step of an upcoming intervention study, will be useful for improving knowledge and self-management strategies of teens. ⓘ Park, Bu Kyung; Kim, Ji Yoon; Rogers, Valerie E. ⓘ Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, 680 Gukchaegosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA ⓘ ⓘ 57199829070; 57205408095; 57207541201 ⓘ bukpark@knu.ac.kr; ⓘ JOURNAL OF MEDICAL INTERNET RESEARCH ⓘ J MED INTERNET RES ⓘ 1438-8871 22 7 SCIE HEALTH CARE SCIENCES & SERVICES;MEDICAL INFORMATICS ⓘ 2020 5.428 8.9 0.21 2025-06-25 ⓘ 5 6 pediatric cancer patients; childhood cancer; social network site; Facebook; usability ⓘ PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; SOCIAL MEDIA; SURVIVORS; ADOLESCENT; RECOMMENDATIONS; EDUCATION; CARE ⓘ Childhood cancer; Facebook; Pediatric cancer patients; Social network site; Usability ⓘ Adolescent; Child; Counseling; Humans; Internet-Based Intervention; Neoplasms; Social Media; Survival Analysis; antineoplastic agent; filgrastim; granulocyte colony stimulating factor; adolescent; aplastic anemia; Article; brain tumor; cancer chemotherapy; cancer therapy; childhood cancer; childhood leukemia; clinical article; content analysis; controlled study; cord blood stem cell transplantation; female; health care utilization; heuristics; home care; human; male; needs assessment; neutropenia; patient safety; patient satisfaction; peripheral blood stem cell transplantation; program development; self care; social life; social media; web-based intervention; child; counseling; mortality; neoplasm; procedures; social media; survival analysis ⓘ English 2020 2020-07-28 10.2196/18779 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Review ⓘ Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency ⓘ According to data compiled by researchers at Johns Hopkins University in Baltimore, Maryland, more than two and half million cases of coronavirus disease 2019 (COVID-19), caused by a newly discovered virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been confirmed on April 20, 2020 (Nature, 2020b). Since the emergence of this infectious disease in Asia (Wuhan, China) late last year, it has been subsequently span to every continent of the world except Antarctica (Rodriguez-Morales et al., 2020). Along with a foothold in every country, the current disease pandemic is disrupting practically every aspect of life all over the world. As the outbreak are continuing to evolve, several research activities have been conducted for better understanding the origin, functions, treatments, and preventions of this novel coronavirus. This review will be a summa of the key features of novel coronavirus (nCoV), the virus causing disease 2019 and the present epidemic situation worldwide up to April 20, 2020. It is expected that this record will play an important role to take more preventive measures for overcoming the challenges faced during this current pandemic. (C) 2020 Elsevier B.V. All rights reserved. ⓘ Acter, Thamina; Uddin, Nizam; Das, Jagotamoy; Akhter, Afroza; Choudhury, Tasrina Rabia; Kim, Sunghwan ⓘ East West Univ, Dept Math & Phys Sci, A-2,Jahurul Islam Ave, Dhaka 1212, Bangladesh; Daffodil Int Univ, Fac Allied Hlth Sci, Dept Nutr & Food Engn, 102 Shukrabad, Dhaka 1207, Bangladesh; Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada; Bangladesh Atom Energy Commiss BAEC, Dhaka Med Coll Hosp Campus, Inst Nucl Med & Allied Sci, Dhaka, Bangladesh; Bangladesh Atom Energy Commiss BAEC, Atom Energy Ctr, Chem Div, Analyt Chem Lab, Dhaka, Bangladesh; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea ⓘ Uddin, Dr. Nizam/N-3536-2014; Kim, Sunghwan/HKN-9812-2023; Choudhury, Tasrina/ABA-9857-2020; Uddin, Nizam/N-3536-2014; Das, Jagotamoy/E-2559-2016 ⓘ 56768064900; 57188533756; 15622886600; 57213251890; 55097929500; 57203772967 ⓘ drnizam.nfe0041.c@diu.edu.bd; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 730 SCIE ENVIRONMENTAL SCIENCES ⓘ 2020 7.963 8.9 4.94 2025-06-25 ⓘ 360 404 Novel coronavirus; Respiratory disease; Epidemic; Public health ⓘ TEMPERATURE-INDUCED STRESS; COMMON COLD VIRUS; MOLECULAR-BIOLOGY; TRANSMISSION; INFLUENZA; SARS; INFECTION; 2019-NCOV; RECEPTOR; MERS ⓘ Epidemic; Novel coronavirus; Public health; Respiratory disease ⓘ Betacoronavirus; Coronavirus Infections; Global Health; Pandemics; Pneumonia, Viral; Baltimore; Maryland; United States; Coronavirus; SARS coronavirus; Viruses; antiinfective agent; antipyretic agent; Coronaviruses; Global health; Infectious disease; Johns hopkins universities; Preventive measures; Research activities; Severe acute respiratory syndrome coronavirus; Wuhan , China; COVID-19; disease control; disease spread; epidemic; severe acute respiratory syndrome; viral disease; adult respiratory distress syndrome; artificial ventilation; contamination; coronavirus disease 2019; disease transmission; disinfection; emergency; endotracheal intubation; environmental factor; evolution; fever; gene sequence; geographic distribution; global health; hand washing; health hazard; human; infection prevention; nonhuman; nucleic acid amplification; oxygen therapy; pandemic; priority journal; quarantine; Review; sepsis; serology; Severe acute respiratory syndrome coronavirus 2; social isolation; symptomatology; thorax radiography; virus pathogenesis; virus replication; virus transmission; winter; Betacoronavirus; Coronavirus infection; global health; virus pneumonia; Diseases ⓘ English 2020 2020-08-15 10.1016/j.scitotenv.2020.138996 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Inhibitory functions of maslinic acid, a natural triterpene, on HMGB1-mediated septic responses ⓘ Background: Maslinic acid (MA), a natural triterpenoid from Olea europaea, prevents oxidative stress and proinflammatory cytokine generation. High mobility group box 1 (HMGB1) has been recognized as a late mediator of sepsis, and the inhibition of the release of HMGB1 and the recovery of vascular barrier integrity have emerged as attractive therapeutic strategies for the management of sepsis. Methods: We tested the hypothesis that MA induces sirtuin 1 and heme oxygenase-1, which inhibit the release of HMGB1 in lipopolysaccharide (LPS)-stimulated cells, thus inhibiting HMGB1-induced hyperpermeability and increasing the survival of septic mice. MA was administered after LPS or HMGB1 challenge, and the antiseptic activity of MA was determined based on permeability, the activation of pro-inflammatory proteins, and the production of markers for tissue injury in HMGB1-activated human umbilical vein endothelial cells (HUVECs) and a cecal ligation and puncture (CLP)-induced sepsis mouse model. Results: MA significantly reduced the release of HMGB1 in LPS-activated HUVECs and attenuated the CLP-induced release of HMGB1. Additionally, MA alleviated HMGB1-mediated vascular disruption and inhibited hyperpermeability in mice, and in vivo analysis revealed that MA reduced sepsis-related mortality and tissue injury. Conclusion: Taken together, the present results suggest that MA reduced HMGB1 release and septic mortality and thus may be useful in the treatment of sepsis. ⓘ Lee, Wonhwa; Lee, Hayeong; Lee, Taeho; Park, Eui Kyun; Bae, Jong-Sup ⓘ Kyungpook Natl Univ, Res Inst Pharmaceut Sci, BK21 Plus KNU Multiom Based Creat Drug Res Team, Coll Pharm,CMRI, 80 Daehak Ro, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Aging Res Ctr, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Daegu 41940, South Korea ⓘ Bae, Jong-Sup/AAU-9724-2020; Lee, Wonhwa/GLQ-6506-2022 ⓘ 50161632800; 55876041100; 57204032003; 37071072400; 16021543200 ⓘ baejs@knu.ac.kr; ⓘ PHYTOMEDICINE ⓘ PHYTOMEDICINE ⓘ 0944-7113 1618-095X 69 SCIE CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES ⓘ 2020 5.34 8.9 1.85 2025-06-25 ⓘ 25 25 Maslinic acid; Endothelium; HMGB1; Sepsis ⓘ IMPROVES SURVIVAL; CELLS; HMGB1; LIPOPOLYSACCHARIDE; ZINGERONE; EXTRACT; MEDIATOR; SEPSIS; DAMAGE; HMG-1 ⓘ Endothelium; HMGB1; Maslinic acid; Sepsis ⓘ Animals; Cell Adhesion; Cytokines; Disease Models, Animal; Heme Oxygenase-1; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Male; Mice, Inbred C57BL; Neutrophils; Sepsis; Sirtuin 1; Triterpenes; advanced glycation end product receptor; alanine aminotransferase; aspartate aminotransferase; creatinine; endothelial leukocyte adhesion molecule 1; heme oxygenase 1; high mobility group B1 protein; immunoglobulin enhancer binding protein; intercellular adhesion molecule 1; interleukin 1beta; interleukin 6; lactate dehydrogenase; lipopolysaccharide; maslinic acid; mitogen activated protein kinase 3; mitogen activated protein kinase p38; sirtuin 1; toll like receptor 2; toll like receptor 4; tumor necrosis factor; zingerone; cytokine; heme oxygenase 1; high mobility group B1 protein; HMOX1 protein, human; lipopolysaccharide; maslinic acid; SIRT1 protein, human; sirtuin 1; triterpene; alanine aminotransferase blood level; animal experiment; animal model; animal tissue; antiinflammatory activity; antimicrobial activity; Article; aspartate aminotransferase blood level; blood vessel permeability; cecal ligation and puncture-induced sepsis; cell adhesion; cell viability; controlled study; creatinine blood level; enzyme linked immunosorbent assay; human; human cell; in vitro study; in vivo study; lactate dehydrogenase blood level; leukocyte migration; liver protection; lung edema; lung injury; lung parenchyma; male; mouse; neutrophil; neutrophil chemotaxis; nonhuman; olive tree; oxidative stress; priority journal; protein expression level; protein secretion; renal protection; survival rate; tissue injury; umbilical vein endothelial cell; urea nitrogen blood level; animal; C57BL mouse; disease model; drug effect; metabolism; mortality; pathology; sepsis ⓘ English 2020 2020-04 10.1016/j.phymed.2020.153200 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures ⓘ Cisplatin (CP) is a chemotherapeutic drug used to treat cancerous solid tumors, but it causes serious side effects, including ototoxicity. The major cause of CP-induced ototoxicity is increased levels of mitochondrial reactive oxygen species (ROS). In this study, we examined the effect of 2-Isopropyl-3H-naphtho(1,2-d)imidazole-4,5-dione (KL1333), a beta-lapachone derivative, on CP-induced ototoxicity using ex vivo organotypic culture system of cochlea. Hair cell damages in CP-treated cochlear explants with or without KL1333 were compared by immunohistochemistry. CP-induced oxidative stress and the preventive effect of KL1333 were analyzed by measuring intracellular ROS levels and depolarization of mitochondrial membrane potential. Activation of apoptosis signaling pathway was detected using TUNEL assay and immunostaining of cleaved caspase-3. As the results, it was found that KL1333 pretreatment significantly decreased stereocilia degeneration and hair cell loss, and prevented an increase in mitochondrial ROS levels in response to CP. Immunohistochemical examinations of cochlear explants revealed greater caspase-3 immunopositivity in the CP group than in controls, while the KL1333 + CP group showed significantly less immunopositivity than the CP group (P<0.05). Thus, it appeared that KL1333 protected hair cells in the organ of Corti from CP-induced apoptosis by decreasing mitochondrial damages due to the production of mitochondrial ROS. This study is the first report showed the preventive effect of KL1333 against CP-induced ototoxicity. Although further studies should be performed to determine if KL1333 could maintain anticancer effect of CP, our data cautiously suggests that the antioxidant KL1333 can be used as an effective anti-apoptotic agent to prevent ototoxicity caused by CP-induced oxidative stress, and may prove useful in preventing hearing loss caused by CP. ⓘ Lee, Han-Sol; Kim, Ye-Ri; Lee, In-Kyu; Kim, Un-Kyung; Baek, Jeong-In; Lee, Kyu-Yup ⓘ Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus Project, KNU Creat BioRes Grp, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Res Inst Aging & Metab, Dept Internal Med, Daegu, South Korea; Daegu Haany Univ, Coll Herbal Bioind, Dept Aroma Appl Ind, Gyongsan 38610, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu 41944, South Korea ⓘ Lee, Doh Young/GLR-9586-2022; Baek, Jeong-In/AAD-2164-2019; Lee, In-Kyu/AAR-6374-2021; Kim, Seung/N-5248-2019 ⓘ 57215775085; 56048344100; 36071537600; 7102248968; 25651687700; 22135779500 ⓘ baek@dhu.ac.kr;kylee@knu.ac.kr; ⓘ BIOMEDICINE & PHARMACOTHERAPY ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 126 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2020 6.53 8.9 0.53 2025-06-25 ⓘ 13 12 Cochlear explant; Cisplatin; KL1333; ROS; Mitochondria ⓘ INDUCED NEPHROTOXICITY; APOPTOSIS; ADENOSINE; METABOLISM; ACTIVATION; RECEPTOR; STRESS; DEATH ⓘ Cisplatin; Cochlear explant; KL1333; Mitochondria; ROS ⓘ Animals; Antioxidants; Apoptosis; Cisplatin; Cochlea; Hair Cells, Auditory; Immunohistochemistry; Membrane Potential, Mitochondrial; Mice; Mitochondria; Naphthoquinones; Ototoxicity; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Tissue Culture Techniques; beta lapachone; caspase 3; cisplatin; kl 1333; reactive oxygen metabolite; antioxidant; beta-lapachone; cisplatin; naphthoquinone; protective agent; reactive oxygen metabolite; animal tissue; antioxidant activity; apoptosis; Article; cell loss; cell protection; cochlea; controlled study; Corti organ; degeneration; explant; hair cell; hearing impairment; immunohistochemistry; membrane depolarization; mitochondrial membrane potential; mouse; nonhuman; ototoxicity; oxidative stress; priority journal; signal transduction; stereocilium; TUNEL assay; animal; chemistry; cochlea; cochlear hair cell; drug effect; metabolism; mitochondrion; ototoxicity; tissue culture technique ⓘ English 2020 2020-06 10.1016/j.biopha.2020.110068 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Polyozellin alleviates atopic dermatitis-like inflammatory and pruritic responses in activated keratinocytes and mast cells ⓘ Polyozellus multiplex is an edible mushroom that offers beneficial pharmacological effects against intestinal inflammation and cancer. Previous studies have demonstrated that polyozellin, a major component of P. multiplex, has therapeutic activities against inflammation, cancer, and oxidative stress-related disorders. This study aimed to determine the pharmacological effects of polyozellin on inflammatory and pruritic responses, the major symptoms of atopic dermatitis (AD), and to define its underlying mechanism of action. Our results showed that polyozellin inhibited the expression of inflammatory cytokines and chemokines through blockade of signal transducer and activator of transcription 1 and nuclear factor-kappa B in activated keratinocytes, the major cells involved in AD progression. Based on the histological and immunological analyses, oral treatment with polyozellin attenuated the Dermatophagoides farinae extract (DFE)/2,4-dinitrochlorobenzene (DNCB)-induced atopic inflammatory symptoms in the skin. Pruritus is an unpleasant sensation for AD patients that causes scratching behavior and ultimately exacerbates the severity of AD. To find a possible explanation for the anti-pruritic effects of polyozellin, we investigated its effects on mast cells and mast cell-derived histamines. Oral treatment with polyozellin reduced the DFE/DNCB-induced tissue infiltration of mast cells, the serum histamine levels, and the histaminergic scratching behaviors. Additionally, polyozellin decreased the immunoglobulin E-stimulated degranulation of mast cells. Taken together, the findings of this study provide us with novel insights into the potential pharmacological targets of polyozellin for treating AD by inhibiting the inflammatory and pruritic responses. ⓘ Jeong, Na-Hee; Lee, Soyoung; Choi, Jin Kyeong; Choi, Young-Ae; Kim, Min-Jong; Lee, Hyun-Shik; Shin, Tae-Yong; Jang, Yong Hyun; Song, Kyung-Sik; Kim, Sang-Hyun ⓘ Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; NEI, Mol Immunol Sect, Lab Immunol, NIH, Bethesda, MD 20892 USA; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu, South Korea; Woosuk Univ, Coll Pharm, Jeonju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, GHAM BioPharm Co Ltd, Daegu, South Korea ⓘ ⓘ 57194410234; 8537269200; 50261279600; 7404777420; 57192888932; 16316010200; 7201493155; 57016046400; 13310139000; 57210450420 ⓘ yhjang@knu.ac.kr;kssong@knu.ac.kr;shkim72@knu.ac.kr; ⓘ BIOMEDICINE & PHARMACOTHERAPY ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 122 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2020 6.53 8.9 0.79 2025-06-25 ⓘ 12 11 Atopic dermatitis; Keratinocytes; Mast cells; Polyozellin ⓘ NF-KAPPA-B; CYTOKINES; DIFFERENTIATION; MULTIPLEX; PATHWAYS; FEATURES ⓘ Atopic dermatitis; Keratinocytes; Mast cells; Polyozellin ⓘ Animals; Cell Line; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Female; Furans; Histamine; Humans; Immunoglobulin E; Inflammation; Keratinocytes; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; Skin; Tumor Necrosis Factor-alpha; 1 chloro 2,4 dinitrobenzene; antiinflammatory agent; chemokine; cytokine; dermatological agent; dexamethasone; gamma interferon; house dust mite allergen extract; immunoglobulin enhancer binding protein; polyozellin; STAT1 protein; tumor necrosis factor; unclassified drug; 1 chloro 2,4 dinitrobenzene; cytokine; furan derivative; histamine; immunoglobulin E; immunoglobulin enhancer binding protein; polyozellin; tumor necrosis factor; animal experiment; animal model; Article; atopic dermatitis; controlled study; disease exacerbation; disease severity; drug mechanism; female; histology; keratinocyte; mast cell; mast cell degranulation; mouse; nonhuman; priority journal; protein expression; pruritus; scratching; signal transduction; animal; atopic dermatitis; Bagg albino mouse; cell line; drug effect; human; inflammation; keratinocyte; mast cell; metabolism; skin ⓘ English 2020 2020-02 10.1016/j.biopha.2019.109743 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Scrophularia buergeriana attenuates allergic inflammation by reducing NF-κB activation ⓘ Background: Scrophularia buergeriana Miq. (Scrophulariaceae) (SB) has been used as an oriental medicine for the treatment of inflammatory diseases, such as neuritis and pharyngolaryngitis. Purpose: We explored the therapeutic effects of S. buergeriana ethanol extract (SBE) on airway inflammation in ovalbumin (OVA)-induced asthmatic mice and lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Methods: Mice were intraperitoneally injected with OVA on days 0 and 14 to elevate the immune response. On days 21 to 23, the mice were challenged with OVA solution and SBE (20 and 40 mg/kg) was administered daily by oral gavage from days 18 to 23. RAW264.7 cells were pretreated with SBE 1 h before LPS stimulation. Results: SBE administration effectively suppressed inflammatory cell infiltration, the expression of interleukin (IL)-5, IL-13, and IL-17, immunoglobulin E, and airway hyperresponsiveness in an OVA-induced allergic asthma model. A reduction in histological alterations, including airway inflammation and mucus hypersecretion, was observed. These effects of SBE were accompanied by a decrease in matrix metalloproteinase-9 (MMP-9) expression and nuclear factor kappa B (NF-kappa B) phosphorylation. These responses were observed in LPS-stimulated RAW264.7 cells. SBE treatment reduced the mRNA expression of tumor necrosis factor (TNF)-alpha, IL-6, and MMP-9, and NF-kappa B phosphorylation, in LPS-stimulated RAW264.7 cells. Conclusion: Our results indicated that SBE effectively attenuated airway inflammation in an OVA-induced allergic asthma model. These properties of SBE were thought to be involved in the suppression of NF-kappa B phosphorylation, suggesting that the material has the potential to regulate the development of allergic asthma. ⓘ Shin, Na-Rae; Lee, A. Yeong; Song, Jun-Ho; Yang, Sungyu; Park, Inkyu; Lim, Je-Oh; Jung, Tae-Yang; Ko, Je-Won; Kim, Jong-Choon; Lim, Kyung Seob; Lee, Min Young; Shin, In-Sik; Kim, Joong Sun ⓘ Chonnam Natl Univ, Coll Vet Med, BK21 Project Team, 77 Yongbong Ro, Gwangju 61186, South Korea; Korea Inst Oriental Med, Herbal Med Resources Res Ctr, 111 Geonjae Ro, Naju Si 58245, Jeollanam Do, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Yeongudanji Ro 30, Cheongju 28116, Chungcheongbuk, South Korea; Kyungpook Natl Univ, Coll Pharm, Daehakro 80, Daegu 41566, South Korea ⓘ Park, Inkyu/S-7293-2019; Lee, A Yeong/ABP-3962-2022; Kim, Jong-Choon/AAP-6135-2020; Song, Jun-Ho/AAA-2854-2021; shin, i/JCE-1227-2023; Lee, Hye/D-9081-2016 ⓘ 55873507200; 7405631098; 57189064445; 56779233700; 57194592547; 57189727182; 57217748039; 56528823300; 36062394700; 36470521900; 15119890400; 35202055600; 7601371367 ⓘ dvmmk79@gmail.com;centraline@kiom.re.kr; ⓘ PHYTOMEDICINE ⓘ PHYTOMEDICINE ⓘ 0944-7113 1618-095X 67 SCIE CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE;PHARMACOLOGY & PHARMACY;PLANT SCIENCES ⓘ 2020 5.34 8.9 2.43 2025-06-25 ⓘ 34 37 Scrophularia buergeriana; Allergic asthma; Pro-inflammatory cytokine; Matrix metalloproteinase-9; Nuclear factor kappa B ⓘ AIRWAY INFLAMMATION; MATRIX METALLOPROTEINASES; IRIDOID GLYCOSIDES; MURINE MODEL; MATRIX-METALLOPROTEINASE-9; INHIBITION; EXPRESSION; CYTOKINES; ASTHMA; CELLS ⓘ Allergic asthma; Matrix metalloproteinase-9; Nuclear factor kappa B; Pro-inflammatory cytokine; Scrophularia buergeriana ⓘ Animals; Asthma; Disease Models, Animal; Female; Hypersensitivity; Immunoglobulin E; Inflammation; Lipopolysaccharides; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Phosphorylation; Plant Extracts; RAW 264.7 Cells; Scrophularia; 8 acetyl harpagide; angoroside C; antiinflammatory agent; aucubin; gelatinase B; harpagide; harpagoside; immunoglobulin E; immunoglobulin enhancer binding protein; interleukin 13; interleukin 17; interleukin 5; interleukin 6; messenger RNA; montelukast; plant extract; Scrophularia buergeriana extract; tumor necrosis factor; unclassified drug; gelatinase B; immunoglobulin E; immunoglobulin enhancer binding protein; lipopolysaccharide; Mmp9 protein, mouse; ovalbumin; plant extract; allergic asthma; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; bronchoalveolar lavage fluid; cell infiltration; cell viability; controlled study; down regulation; drug effect; eosinophil count; female; high performance liquid chromatography; histopathology; inflammatory cell; lipopolysaccharide-induced acute lung injury; mouse; mRNA expression level; mucus secretion; nonhuman; ovalbumin-induced airway inflammation; priority journal; protein phosphorylation; RAW 264.7 cell line; respiratory tract allergy; Scrophularia; Scrophularia buergeriana; animal; asthma; Bagg albino mouse; chemistry; disease model; hypersensitivity; inflammation; metabolism; pathophysiology; phosphorylation; Scrophularia ⓘ English 2020 2020-02 10.1016/j.phymed.2019.153159 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Selective separation of Cs-contaminated clay from soil using polyethylenimine-coated magnetic nanoparticles ⓘ We evaluated the feasibility of using magnetic nanoparticles (MNPs) coated with polyethylen mine (PEI), a cationic polymer, to remediate radioactive contaminated soil by separating Cs-contaminated clay from the soil. The influences of the solution pH, PEI-to-MNPs mass ratio, and the PEI-MNPs dose on the magnetic separation performance were systematically examined. The highest SE% of illite from solution through electrostatic attraction was approximately 100% at a mass ratio of 0.04 g-PEI-MNPs/g-clay. The PEl coating clearly enhanced the adhesion between MNPs and clay minerals by increasing the quantity of functional amine groups available for adsorbing negatively charged clay minerals. In separation experiments using a soil mixture, the PEI-coated MNPs selectively separated clay- and silt-sized fine particles smaller than 0.038 mm even in the presence of a large amount of sand when used at a low dose (mass ratio of 0.05 g-PEI-MNPs/g-clay) and without pH control. We also used the PEI-MNPs to separate Cs-137-contaminated illite from soil under an external magnetic field. After magnetic separation, the highest removal efficiency achieved for Cs-137 removal from the treated soil was 81.7% at a low nanoparticle dosage, which resulted in satisfying the reduction of radioactivity and waste volume. The results clearly demonstrate that the selective separation of Cs-contaminated clay using PEI-coated MNPs is a promising technique for remediating radioactive soil. (C) 2019 Elsevier B.V. All rights reserved. ⓘ Kim, June-Hyun; Kim, Sung-Man; Yoon, In-Ho; Choi, Sang-June; Kim, Ilgook ⓘ Korea Atom Energy Res Inst, Decommissioning Technol Res Div, 111 Daedeok Daero 989beon-gil, Daejeon, South Korea; KyungPook Natl Univ, Sch Architectural Civil Environm & Energy Engn, 80 Daehak Ro, Daegu, South Korea ⓘ ; Yoon, In-Ho/S-2386-2017 ⓘ 57211214201; 57211217712; 8527138200; 56605563600; 56449775700 ⓘ ilgook@kaeri.re.kr; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 706 SCIE ENVIRONMENTAL SCIENCES ⓘ 2020 7.963 8.9 1.19 2025-06-25 ⓘ 31 36 Magnetic separation; PEI-Fe3O4 nanocomposites; Cesium; Clay; Soil remediation ⓘ FE3O4 NANOPARTICLES; HARVESTING MICROALGAE; RADIOACTIVE CESIUM; FUKUSHIMA; RADIOCESIUM; ADSORPTION; REMOVAL; DESORPTION; MIGRATION; EFFICIENT ⓘ Cesium; Clay; Magnetic separation; PEI-Fe<sub>3</sub>O<sub>4</sub> nanocomposites; Soil remediation ⓘ Cesium; Clay; Clay minerals; Contamination; Iron oxides; Magnetic separation; Magnetite; Nanomagnetics; Nanoparticles; Radioactivity; Remediation; Soil conservation; Soil pollution control; Soils; amine; cesium 137; functional group; magnetic nanoparticle; nanoparticle; polyethyleneimine; Electrostatic attractions; External magnetic field; Magnetic nano-particles; Magnetic nanoparti cles (MNPs); Removal efficiencies; Selective separation; Separation performance; Soil remediation; cesium; clay; concentration (composition); magnetic property; nanocomposite; nanoparticle; separation; soil pollution; soil remediation; adsorption; Article; feasibility study; magnetic field; magnetic separation; particle size; pH; priority journal; radioactivity; reduction (chemistry); sand; separation technique; soil pollution; static electricity; Soil pollution ⓘ English 2020 2020-03-01 10.1016/j.scitotenv.2019.136020 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Snowballing transmission of COVID-19 (SARS-CoV-2) through wastewater: Any sustainable preventive measures to curtail the scourge in low-income countries? ⓘ In this communication, we proposed sustainable preventive measures that may be adopted by the low-income countries to forestall the potential outbreak and transmission of COVID-19 (coronavirus disease 2019) through wastewater. Most low-income countries have poor sanitation and wastewater management policies, which create potential risks of COVID 19 spread. Hence, the proposed measures include decentralization of wastewater treatment facilities, community-wide monitoring and testing of SARS-CoV-2 in wastewater samples, improved Editor: Damia Barcelo sanitation, developing point-of-use devices for wastewater decontamination, and more focused policy interventions. Therefore, this paper adds useful insights into the monitoring and management of ongoing COVID-19 out-break in low-income countries. (C) 2020 Elsevier B.V. All rights reserved. ⓘ Adelodun, Bashir; Ajibade, Fidelis Odedishemi; Ibrahim, Rahmat Gbemisola; Bakare, Hashim Olalekan; Choi, Kyung-Sook ⓘ Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Fed Univ Technol Akure, Dept Civil & Environm Engn, PMB 704, Akure, Nigeria; Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China; Kwara State Minist Hlth, Ilorin, Kwara State, Nigeria; Univ Ilorin, Dept Chem Engn, PMB 1515, Ilorin, Nigeria; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea ⓘ Adelodun, Bashir/O-2941-2018; Ajibade, Fidelis/D-7893-2019; Ajibade, Fidelis O./D-7893-2019 ⓘ 57193774482; 57190341647; 57217480064; 57217480405; 54392662900 ⓘ adelodun.b@unilorin.edu.ng;ks.choi@knu.ac.kr; ⓘ SCIENCE OF THE TOTAL ENVIRONMENT ⓘ SCI TOTAL ENVIRON ⓘ 0048-9697 1879-1026 742 SCIE ENVIRONMENTAL SCIENCES ⓘ 2020 7.963 8.9 3.67 2025-06-25 ⓘ 78 91 COVID-19; Coronavirus transmission; Low-income countries; SARS-CoV-2; Wastewater reuse ⓘ CORONAVIRUS; RESOURCES; POLLUTION; AFRICA; HEALTH; RISK ⓘ Coronavirus transmission; COVID-19; Low-income countries; SARS-CoV-2; Wastewater reuse ⓘ Betacoronavirus; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; Waste Water; Coronavirus; SARS coronavirus; Developing countries; Diseases; Sanitation; virus RNA; Low income countries; Monitoring and management; Point-of-use devices; Policy intervention; Preventive measures; Wastewater decontamination; Wastewater management; Wastewater treatment facilities; COVID-19; developing world; disease control; disease transmission; respiratory disease; severe acute respiratory syndrome; wastewater; Article; community care; coronavirus disease 2019; cost; decontamination; health care policy; human; infection control; infection prevention; low income country; prevalence; priority journal; sanitation; Severe acute respiratory syndrome coronavirus 2; sustainable development; technology; ultraviolet radiation; virus transmission; waste component removal; waste water; waste water treatment plant; water quality; water sampling; Betacoronavirus; Coronavirus infection; pandemic; virus pneumonia; waste water; Wastewater treatment ⓘ English 2020 2020-11-10 10.1016/j.scitotenv.2020.140680 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Abstractive summarization of long texts by representing multiple compositionalities with temporal hierarchical pointer generator network ⓘ In order to tackle the problem of abstractive summarization of long multi-sentence texts, it is critical to construct an efficient model, which can learn and represent multiple compositionalities better. In this paper, we introduce a temporal hierarchical pointer generator network that can represent multiple compositionalities in order to handle longer sequences of texts with a deep structure. We demonstrate how a multilayer gated recurrent neural network organizes itself with the help of an adaptive timescale in order to represent the compositions. The temporal hierarchical network is implemented with a multiple timescale architecture where the timescale of each layer is also learned during the training process through error backpropagation through time. We evaluate our proposed model using an Introduction-Abstract summarization dataset from scientific articles and the CNN/Daily Mail summarization benchmark dataset. The results illustrate that, we successfully implement a summary generation system for long texts by using the multiple timescale with adaptation concept. We also show that we have improved the summary generation system with our proposed model on the benchmark dataset. (C) 2019 Elsevier Ltd. All rights reserved. ⓘ Moirangthem, Dennis Singh; Lee, Minho ⓘ Kyungpook Natl Univ, Sch Elect Engn, IT 1, 80 Daehakro, Daegu 41566, South Korea ⓘ Lee, Min-Ho/ABE-5735-2021 ⓘ 57195432297; 57191730119 ⓘ mdennissingh@gmail.com;mholee@gmail.com; ⓘ NEURAL NETWORKS ⓘ NEURAL NETWORKS ⓘ 0893-6080 1879-2782 124 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES ⓘ 2020 8.05 9.0 0.99 2025-06-25 ⓘ 19 28 Automatic summarization; Abstraction; RNN encoder-decoder; Seq2seq; Multiple timescale; Temporal hierarchy; Pointer generator ⓘ NEURAL-NETWORKS; BRAIN ⓘ Abstraction; Automatic summarization; Multiple timescale; Pointer generator; RNN encoder–decoder; Seq2seq; Temporal hierarchy ⓘ Machine Learning; Periodicals as Topic; Word Processing; Abstracting; Multilayer neural networks; Abstraction; Automatic summarization; Pointer generator; Seq2seq; Temporal hierarchy; Time-scales; article; back propagation; recurrent neural network; machine learning; procedures; publication; word processing; Recurrent neural networks ⓘ English 2020 2020-04 10.1016/j.neunet.2019.12.022 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Decomposition of the PET Film by MHETase Using Exo-PETase Function ⓘ Monohydroxyethyl terephthalate (MHET) hydrolase (MHETase) is an enzyme known to be involved in the final degradation step of poly(ethylene terephthalate) (PET) by hydrolyzing MHET into terephthalic acid and ethylene glycol in Ideonella sakaiensis. Here, we report the extracellular production of MHETase in an active form with a proper folding. Based on the structural observations and biochemical experiments, we reveal that MHETase also functions as exo-PETase by hydrolyzing the synthesized PET pentamer. We further present that MHETase has a hydrolysis activity against the termini-generated PET film, demonstrating the exo-PETase function of the enzyme. We also develop a MHETase(R411K/S416A/F424I) variant with a higher BHET activity, and the variant exhibits an enhanced degradation activity against the PET film. Based on these results, we propose that MHETase plays several roles in the biodegradation of PET using the BHETase and exo-PETase activities as well as the MHET hydrolysis function. ⓘ Sagong, Hye-Young; Seo, Hogyun; Kim, Taeho; Son, Hyeoncheol Francis; Joo, Seongjoon; Lee, Seul Hoo; Kim, Seongmin; Woo, Jae-Sung; Hwang, Sung Yeon; Kim, Kyung-Jin ⓘ Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Pohang Accelerator Lab, Pohang 37673, South Korea; Korea Res Inst Chem Technol KRICT, Res Ctr Ind Chem Biotechnol, Ulsan 44429, South Korea; Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea; Korea Univ, Dept Life Sci, Seoul 02841, South Korea; Univ Sci & Technol UST, Green Chem & Environm Biotechnol, Daejeon 34113, South Korea ⓘ Hwang, Sung/K-3173-2017; Woo, Jae-Sung/J-4531-2017; Hwang, Sung Yeon/K-3173-2017; Kim, Kyung-Jin/MVY-3405-2025 ⓘ 57006554000; 57189697998; 57220044193; 56015598000; 57190377309; 57205261937; 57204760454; 12795708700; 14022878900; 55510867400 ⓘ kkim@knu.ac.kr; ⓘ ACS CATALYSIS ⓘ ACS CATAL ⓘ 2155-5435 10 8 SCIE CHEMISTRY, PHYSICAL ⓘ 2020 13.084 9.0 3.16 2025-06-25 ⓘ 104 105 polyethylene terephthalate (PET); biodegradation; MHETase; Ideonella sakaiensis; extracellular production; exo-PETase ⓘ CUTINASE; SAKAIENSIS; FUSION ⓘ biodegradation; exo-PETase; extracellular production; Ideonella sakaiensis; MHETase; polyethylene terephthalate (PET) ⓘ Aliphatic compounds; Biodegradation; Enzymes; Ethylene; Ethylene glycol; Biochemical experiments; Degradation activity; Extracellular; Hydrolysis activity; Poly(ethylene terephthalate) (PET); Structural observations; Terephthalate; Terephthalic acids; Hydrolysis ⓘ English 2020 2020-04-17 10.1021/acscatal.9b05604 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ FexNi2-xP Alloy Nanocatalysts with Electron-Deficient Phosphorus Enhancing the Hydrogen Evolution Reaction in Acidic Media ⓘ Alloying is one of the powerful methods to exceed the intrinsic properties of pure metals; however, it is challenging to understand the exact alloying effect without altering other parameters, such as crystal structure. In this study, we chose iron and nickel phosphides as model catalysts for the hydrogen evolution reaction (HER) to elucidate the alloying effect of FexNi2-xP (x = 0.5, 1.0, and 1.5), which has the same P (6) over bar 2m crystal structure with different alloy compositions. The Fe0.5Ni1.5P catalyst recorded the optimal HER performances, including small overpotential (0.163 V at 50 mA cm(-2)), low Tafel slope (65 mV dec(-1)), and high exchange current density (0.37 mA cm(-2)), which were superior to pure Ni2P, Fe2P, and other FexNi2-xP catalysts in acidic media. The charge of phosphorus atoms in Fe0.5Ni1.5P was proven the most deficient one by X-ray photoelectron spectroscopy (XPS). The extended X-ray absorption fine structure (EXAFS) data supported that the small distortion degree of the metal-metal (M-M) bonds in the Fe0.5Ni1.5P significantly suppresses the metal to phosphorus (M-to-P) charge transfer and increases the electronic deficiency of phosphorus atoms. We also performed the density functional theory (DFT) calculation to support our charge trend of phosphorus and local distortion of M-to-P bonds. Our finding provided the observation of electron-deficient phosphorus sites modulated by the alloy composition of FexNi2-xP and showed how the degree of the M-M bond distortion correlates with HER properties in acidic media. ⓘ Shin, Dongwoo; Kim, Hee Jin; Kim, Minjun; Shin, Dongyup; Kim, Hyungjun; Song, Hyunjoon; Choi, Sang-Il ⓘ Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea; Kyungpook Natl Univ, Dept Chem & Green Nano Mat Res Ctr, Daegu 41566, South Korea ⓘ ; Choi, Sang-Il/AGR-1133-2022; Kim, Hyungjun/B-4527-2013; Choi, Sang-Il/N-7571-2013 ⓘ 56099952600; 57193334513; 57208186810; 57216179109; 58021592600; 7404037292; 56167600800 ⓘ linus16@kaist.ac.kr;hsong@kaist.ac.kr;sichoi@knu.ac.kr; ⓘ ACS CATALYSIS ⓘ ACS CATAL ⓘ 2155-5435 10 19 SCIE CHEMISTRY, PHYSICAL ⓘ 2020 13.084 9.0 1.44 2025-06-25 ⓘ 48 47 iron; nickel; transition metal phosphide; nanocatalysts; hydrogen evolution reaction ⓘ IRON PHOSPHIDE NANOPARTICLES; CATALYSTS; NANOCRYSTALS; ELECTROCATALYST; DEHYDROGENATION; ROBUST; EXAFS; SIZE ⓘ hydrogen evolution reaction; iron; nanocatalysts; nickel; transition metal phosphide ⓘ Alloying; Charge transfer; Crystal atomic structure; Density functional theory; Extended X ray absorption fine structure spectroscopy; Hydrogen; Hydrogen evolution reaction; Iron compounds; Metals; Nanocatalysts; Nickel compounds; Phosphorus compounds; X ray absorption; X ray photoelectron spectroscopy; Alloy compositions; Bond distortions; Distortion degree; Electron-deficient; Exchange current densities; Extended x-ray absorption fine structure datum; Intrinsic property; Phosphorus sites; Iron alloys ⓘ English 2020 2020-10-02 10.1021/acscatal.0c02301 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Prognostic value of tumor budding and large cell nesting in cervical cancer ⓘ ⓘ Lee, Y. S.; Lee, Y. H.; Lee, H. J.; Chong, G. O. ⓘ Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ GYNECOLOGIC ONCOLOGY ⓘ GYNECOL ONCOL ⓘ 0090-8258 1095-6859 159 SCIE OBSTETRICS & GYNECOLOGY;ONCOLOGY ⓘ 2020 5.482 9.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-10 10.1016/j.ygyno.2020.05.296 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Tumor budding in cervical cancer as a prognostic factor and its possible role as an additional intermediate-risk factor ⓘ Objective. To evaluate the prognostic value and its possible role as an additional intermediate-risk factor of tumor budding (TB) in cervical cancer following radical hysterectomy. Methods. In total, 136 patients with cervical cancer who underwent radical hysterectomy with pelvic and/or paraaortic lymphadenectomy were included. We assessed the status of TB in available hematoxylin and eosinstained specimens. Univariate and multivariate analyses for predicting tumor recurrence and death were performed using TB and other clinicopathologic parameters. To evaluate additional intermediate-risk factors of TB. patients who had at least one high-risk factor were excluded, and a total of 81 patients were included. We added TB to three conventional intermediate-risk models and compared their performance with new and conventional models using the log-rank test and receiver operating characteristic analysis. Results. High TB was defined as >= 5 per high-power field for disease-free survival and >= 8 per high-power field for overall survival. Multivariate analysis revealed that high TB was an independent prognostic factor for predicting overall survival (hazard ratio, 4.96; 95% confidence intervals, 1.06-23.29; p = .0423). The addition of TB to the conventional intermediate-risk models improved the accuracy of recurrence prediction. Among the risk models, the new model using at least two risk factors, including tumor size (>= 4 cm), deep stromal invasion (outer one-third of entire cervical thickness), lymphovascular invasion, and high TB, was the most accurate for predicting tumor recurrence (area under the curve, 0.708, hazard ratio, 4.25; p = .0231). Conclusion. High TB may be a prognostic biomarker of cervical cancer. Moreover, the addition of TB to the conventional intermediate-risk models improves the stratification of tumor recurrence. (C) 2020 Published by Elsevier Inc. ⓘ Park, Jee Young; Chong, Gun Oh; Park, Ji Young; Chung, Doyoung; Lee, Yoon Hee; Lee, Hyun Jung; Hong, Dae Gy; Han, Hyung Soo; Lee, Yoon Soon ⓘ Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Clin Omics Res Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea ⓘ Park, Jung Hwan/AAA-1951-2022 ⓘ 57226185359; 23099068000; 57210160197; 57218338728; 37088851700; 57202930844; 26656670100; 7401969388; 27172173100 ⓘ gochong@knu.ac.kr;jyparkmd@knu.ac.kr; ⓘ GYNECOLOGIC ONCOLOGY ⓘ GYNECOL ONCOL ⓘ 0090-8258 1095-6859 159 1 SCIE OBSTETRICS & GYNECOLOGY;ONCOLOGY ⓘ 2020 5.482 9.0 1.52 2025-06-25 ⓘ 19 20 Cervical cancer; Tumor budding; Intermediate-risk; Prognosis ⓘ SQUAMOUS-CELL CARCINOMA; PELVIC RADIATION-THERAPY; RADICAL HYSTERECTOMY; NEST SIZE; STAGE; COLON ⓘ Cervical cancer; Intermediate-risk; Prognosis; Tumor budding ⓘ Adult; Antineoplastic Combined Chemotherapy Protocols; Cervix Uteri; Chemoradiotherapy, Adjuvant; Clinical Decision-Making; Disease-Free Survival; Female; Follow-Up Studies; Humans; Hysterectomy; Lymph Node Excision; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Uterine Cervical Neoplasms; antineoplastic agent; adult; Article; cancer cell; cancer prognosis; cancer recurrence; cancer size; cancer survival; cell budding; controlled study; disease free survival; female; histopathology; human; human cell; lymph node dissection; lymph vessel metastasis; major clinical study; measurement accuracy; middle aged; overall survival; paraaortic lymph node; pelvis lymphadenectomy; predictive value; priority journal; radical hysterectomy; risk factor; stroma; tumor depth; uterine cervix cancer; adjuvant chemoradiotherapy; cancer staging; clinical decision making; epidemiology; follow up; hysterectomy; mortality; pathology; prevention and control; procedures; prognosis; retrospective study; risk assessment; risk factor; surgery; tumor recurrence; uterine cervix; uterine cervix tumor ⓘ English 2020 2020-10 10.1016/j.ygyno.2020.07.030 ⓘ 바로가기 바로가기 바로가기 바로가기
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